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Stefan G. Lechner, Ph.D. - Publications

Affiliations: 
Pharmacology Ruprecht-Karls-University Heidelberg, Heidelberg, Baden-Württemberg, Germany 
Area:
Sensory biology, pain
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tsvilovskyy V, Ottenheijm R, Kriebs U, Schütz A, Diakopoulos KN, Jha A, Bildl W, Wirth A, Böck J, Jaślan D, Ferro I, Taberner FJ, Kalinina O, Hildebrand S, Wissenbach U, ... ... Lechner SG, et al. OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage. The Journal of Clinical Investigation. 134. PMID 38557489 DOI: 10.1172/JCI169428  0.671
2023 Nees TA, Wang N, Adamek P, Zeitzschel N, Verkest C, La Porta C, Schaefer I, Virnich J, Balkaya S, Prato V, Morelli C, Begay V, Lee YJ, Tappe-Theodor A, Lewin GR, ... ... Lechner SG, et al. Role of TMEM100 in mechanically insensitive nociceptor un-silencing. Nature Communications. 14: 1899. PMID 37019973 DOI: 10.1038/s41467-023-37602-w  0.777
2022 Gangadharan V, Zheng H, Taberner FJ, Landry J, Nees TA, Pistolic J, Agarwal N, Männich D, Benes V, Helmstaedter M, Ommer B, Lechner SG, Kuner T, Kuner R. Neuropathic pain caused by miswiring and abnormal end organ targeting. Nature. 606: 137-145. PMID 35614217 DOI: 10.1038/s41586-022-04777-z  0.737
2022 Verkest C, Schaefer I, Nees TA, Wang N, Jegelka JM, Taberner FJ, Lechner SG. Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2. Nature Communications. 13: 1365. PMID 35292651 DOI: 10.1038/s41467-022-28974-6  0.728
2021 Morelli C, Castaldi L, Brown SJ, Streich LL, Websdale A, Taberner FJ, Cerreti B, Barenghi A, Blum KM, Sawitzke J, Frank T, Steffens LK, Doleschall B, Serrao J, Ferrarini D, ... Lechner SG, et al. Identification of a population of peripheral sensory neurons that regulates blood pressure. Cell Reports. 35: 109191. PMID 34077727 DOI: 10.1016/j.celrep.2021.109191  0.778
2020 Schwaller F, Bégay V, García-García G, Taberner FJ, Moshourab R, McDonald B, Docter T, Kühnemund J, Ojeda-Alonso J, Paricio-Montesinos R, Lechner SG, Poulet JFA, Millan JM, Lewin GR. USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans. Nature Neuroscience. PMID 33288907 DOI: 10.1038/s41593-020-00751-y  0.716
2020 Agarwal N, Taberner FJ, Rangel Rojas D, Moroni M, Omberbasic D, Njoo C, Andrieux A, Gupta P, Bali KK, Herpel E, Faghihi F, Fleming T, Dejean A, Lechner SG, Nawroth PP, et al. SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes. Neuron. PMID 32735781 DOI: 10.1016/J.Neuron.2020.06.037  0.757
2020 Jonas R, Prato V, Lechner SG, Groen G, Obreja O, Werland F, Rukwied R, Klusch A, Petersen M, Carr RW, Schmelz M. TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors. Frontiers in Cellular Neuroscience. 14: 13. PMID 32116559 DOI: 10.3389/Fncel.2020.00013  0.348
2019 Taberner FJ, Prato V, Schaefer I, Schrenk-Siemens K, Heppenstall PA, Lechner SG. Structure-guided examination of the mechanogating mechanism of PIEZO2. Proceedings of the National Academy of Sciences of the United States of America. PMID 31235572 DOI: 10.1073/Pnas.1905985116  0.767
2019 Lechner SG. Decision letter: Tactile sensory channels over-ruled by frequency decoding system that utilizes spike pattern regardless of receptor type Elife. DOI: 10.7554/Elife.46510.014  0.307
2018 Schaefer I, Prato V, Arcourt A, Taberner FJ, Lechner SG. [EXPRESS] Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors. Molecular Pain. 1744806918814640. PMID 30387376 DOI: 10.1177/1744806918814640  0.758
2018 Dhandapani R, Arokiaraj CM, Taberner FJ, Pacifico P, Raja S, Nocchi L, Portulano C, Franciosa F, Maffei M, Hussain AF, de Castro Reis F, Reymond L, Perlas E, Garcovich S, Barth S, ... ... Lechner SG, et al. Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons. Nature Communications. 9: 1640. PMID 29691410 DOI: 10.1038/S41467-018-04049-3  0.799
2018 Narayanan P, Hütte M, Kudryasheva G, Taberner FJ, Lechner SG, Rehfeldt F, Gomez-Varela D, Schmidt M. Myotubularin related protein-2 and its phospholipid substrate PIPcontrol Piezo2-mediated mechanotransduction in peripheral sensory neurons. Elife. 7. PMID 29521261 DOI: 10.7554/Elife.32346  0.773
2018 Narayanan P, Hütte M, Kudryasheva G, Taberner FJ, Lechner SG, Rehfeldt F, Gomez-Varela D, Schmidt M. Author response: Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons Elife. DOI: 10.7554/Elife.32346.019  0.75
2017 Prato V, Taberner FJ, Hockley JRF, Callejo G, Arcourt A, Tazir B, Hammer L, Schad P, Heppenstall PA, Smith ES, Lechner SG. Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors. Cell Reports. 21: 3102-3115. PMID 29241539 DOI: 10.1016/J.Celrep.2017.11.066  0.786
2016 Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA, Lechner SG. Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination. Neuron. PMID 27989460 DOI: 10.1016/J.Neuron.2016.11.027  0.786
2016 Moshourab R, Frenzel H, Lechner S, Haseleu J, Bégay V, Omerbašić D, Lewin GR. Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects. Journal of Visualized Experiments : Jove. PMID 27684317 DOI: 10.3791/52966  0.712
2015 Schrenk-Siemens K, Wende H, Prato V, Song K, Rostock C, Loewer A, Utikal J, Lewin GR, Lechner SG, Siemens J. PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors. Nature Neuroscience. 18: 10-6. PMID 25469543 DOI: 10.1038/Nn.3894  0.623
2014 Lewin GR, Lechner SG, Smith ES. Nerve growth factor and nociception: from experimental embryology to new analgesic therapy. Handbook of Experimental Pharmacology. 220: 251-82. PMID 24668476 DOI: 10.1007/978-3-642-45106-5_10  0.717
2013 Lechner SG, Lewin GR. Hairy sensation. Physiology (Bethesda, Md.). 28: 142-50. PMID 23636260 DOI: 10.1152/physiol.00059.2012  0.527
2012 Frenzel H, Bohlender J, Pinsker K, Wohlleben B, Tank J, Lechner SG, Schiska D, Jaijo T, Rüschendorf F, Saar K, Jordan J, Millán JM, Gross M, Lewin GR. A genetic basis for mechanosensory traits in humans. Plos Biology. 10: e1001318. PMID 22563300 DOI: 10.1371/Journal.Pbio.1001318  0.567
2012 Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C. The transcription factor c-Maf controls touch receptor development and function. Science (New York, N.Y.). 335: 1373-6. PMID 22345400 DOI: 10.1126/Science.1214314  0.597
2012 Heidenreich M, Lechner SG, Vardanyan V, Wetzel C, Cremers CW, De Leenheer EM, Aránguez G, Moreno-Pelayo MÁ, Jentsch TJ, Lewin GR. KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. Nature Neuroscience. 15: 138-45. PMID 22101641 DOI: 10.1038/Nn.2985  0.71
2012 Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynzsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, et al. Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain. 153: 184-96. PMID 22071319 DOI: 10.1016/J.Pain.2011.10.014  0.575
2011 Smith ES, OmerbaÅ¡ić D, Lechner SG, Anirudhan G, Lapatsina L, Lewin GR. The molecular basis of acid insensitivity in the African naked mole-rat. Science (New York, N.Y.). 334: 1557-60. PMID 22174253 DOI: 10.1126/Science.1213760  0.73
2011 Lechner SG, Siemens J. Sensory transduction, the gateway to perception: mechanisms and pathology. Embo Reports. 12: 292-5. PMID 21415857 DOI: 10.1038/Embor.2011.45  0.32
2011 Lechner SG, Markworth S, Poole K, Smith ES, Lapatsina L, Frahm S, May M, Pischke S, Suzuki M, Ibañez-Tallon I, Luft FC, Jordan J, Lewin GR. The molecular and cellular identity of peripheral osmoreceptors. Neuron. 69: 332-44. PMID 21262470 DOI: 10.1016/J.Neuron.2010.12.028  0.756
2009 Lechner SG, Lewin GR. Peripheral sensitisation of nociceptors via G-protein-dependent potentiation of mechanotransduction currents. The Journal of Physiology. 587: 3493-503. PMID 19505980 DOI: 10.1113/Jphysiol.2009.175059  0.672
2009 Lechner SG, Frenzel H, Wang R, Lewin GR. Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. The Embo Journal. 28: 1479-91. PMID 19322198 DOI: 10.1038/Emboj.2009.73  0.672
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