| Year |
Citation |
Score |
| 2023 |
Merlo S, Costa L, Chiechio S, Busceti CL, Ciranna L, Santangelo R, Sortino MA, Fornai F, Nicoletti F, Copani A. Increased Heat Pain Tolerance but Hyperalgesia to Tonic Inflammatory Pain in the CRND8 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 96: 77-91. PMID 37742639 DOI: 10.3233/JAD-230148 |
0.301 |
|
| 2022 |
Vicario N, Denaro S, Turnaturi R, Longhitano L, Spitale FM, Spoto S, Marrazzo A, Zappalà A, Tibullo D, Li Volti G, Chiechio S, Pasquinucci L, Parenti R, Parenti C. Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain. International Journal of Molecular Sciences. 23. PMID 35682543 DOI: 10.3390/ijms23115864 |
0.384 |
|
| 2020 |
Vicario N, Turnaturi R, Spitale FM, Torrisi F, Zappalà A, Gulino R, Pasquinucci L, Chiechio S, Parenti C, Parenti R. Intercellular communication and ion channels in neuropathic pain chronicization. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. PMID 32533221 DOI: 10.1007/S00011-020-01363-9 |
0.406 |
|
| 2020 |
Puglia C, Santonocito D, Bonaccorso A, Musumeci T, Ruozi B, Pignatello R, Carbone C, Parenti C, Chiechio S. Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization. Pharmaceutics. 12. PMID 32290081 DOI: 10.3390/Pharmaceutics12040339 |
0.406 |
|
| 2020 |
Turnaturi R, Pasquinucci L, Chiechio S, Grasso M, Marrazzo A, Amata E, Dichiara M, Prezzavento O, Parenti C. Exploiting the power of stereochemistry in drug action: 3-[(2S,6S,11S)-8-hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as potent sigma 1 receptor antagonist. Acs Chemical Neuroscience. PMID 32186844 DOI: 10.1021/Acschemneuro.9B00688 |
0.342 |
|
| 2019 |
Turnaturi R, Chiechio S, Salerno L, Rescifina A, Pittalà V, Cantarella G, Tomarchio E, Parenti C, Pasquinucci L. Progress in the development of more effective and safer analgesics for pain management. European Journal of Medicinal Chemistry. 183: 111701. PMID 31550662 DOI: 10.1016/J.Ejmech.2019.111701 |
0.417 |
|
| 2019 |
Seggio M, Contino A, Maccarrone G, Parenti C, Merlo S, Pappalardo G, Giuffrida A, Chiechio S. Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes. International Journal of Pharmaceutics. 566: 391-399. PMID 31158453 DOI: 10.1016/J.Ijpharm.2019.05.077 |
0.355 |
|
| 2019 |
Romeo G, Prezzavento O, Intagliata S, Pittalà V, Modica MN, Marrazzo A, Turnaturi R, Parenti C, Chiechio S, Arena E, Campisi A, Sposito G, Salerno L. Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands. European Journal of Medicinal Chemistry. 174: 226-235. PMID 31042618 DOI: 10.1016/J.Ejmech.2019.04.056 |
0.386 |
|
| 2019 |
Vicario N, Pasquinucci L, Spitale FM, Chiechio S, Turnaturi R, Caraci F, Tibullo D, Avola R, Gulino R, Parenti R, Parenti C. Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain. Molecular Neurobiology. PMID 31030416 DOI: 10.1007/S12035-019-1607-1 |
0.512 |
|
| 2019 |
Pasquinucci L, Turnaturi R, Calò G, Pappalardo F, Ferrari F, Russo G, Arena E, Montenegro L, Chiechio S, Prezzavento O, Parenti C. (2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist. European Journal of Medicinal Chemistry. 168: 189-198. PMID 30822708 DOI: 10.1016/J.Ejmech.2019.02.043 |
0.319 |
|
| 2019 |
Pasquinucci L, Turnaturi R, Montenegro L, Caraci F, Chiechio S, Parenti C. Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation. European Journal of Pharmacology. 847: 97-102. PMID 30690004 DOI: 10.1016/J.Ejphar.2019.01.031 |
0.417 |
|
| 2017 |
Chiechio S, Canonico PL, Grilli M. l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug. International Journal of Molecular Sciences. 19. PMID 29267192 DOI: 10.3390/Ijms19010011 |
0.333 |
|
| 2017 |
Zammataro M, Merlo S, Barresi M, Parenti C, Hu H, Sortino MA, Chiechio S. Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice. Frontiers in Pharmacology. 8: 743. PMID 29104538 DOI: 10.3389/Fphar.2017.00743 |
0.597 |
|
| 2016 |
Vicario N, Parenti R, Arico' G, Turnaturi R, Scoto GM, Chiechio S, Parenti C. Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. Molecular Pain. 12. PMID 27590071 DOI: 10.1177/1744806916667949 |
0.47 |
|
| 2016 |
Chiechio S. Modulation of Chronic Pain by Metabotropic Glutamate Receptors. Advances in Pharmacology (San Diego, Calif.). 75: 63-89. PMID 26920009 DOI: 10.1016/Bs.Apha.2015.11.001 |
0.477 |
|
| 2015 |
Parenti C, Aricò G, Chiechio S, Di Benedetto G, Parenti R, Scoto GM. Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. Molecules (Basel, Switzerland). 20: 16758-69. PMID 26389871 DOI: 10.3390/Molecules200916758 |
0.392 |
|
| 2015 |
Chiechio S. Modulation of Chronic Pain by Metabotropic Glutamate Receptors Advances in Pharmacology. DOI: 10.1016/bs.apha.2015.11.001 |
0.385 |
|
| 2014 |
Zammataro M, Sortino MA, Parenti C, Gereau RW, Chiechio S. HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors. Molecular Pain. 10: 68. PMID 25406541 DOI: 10.1186/1744-8069-10-68 |
0.646 |
|
| 2013 |
Onofrj M, Ciccocioppo F, Varanese S, di Muzio A, Calvani M, Chiechio S, Osio M, Thomas A. Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. Expert Review of Neurotherapeutics. 13: 925-36. PMID 23965166 DOI: 10.1586/14737175.2013.814930 |
0.439 |
|
| 2012 |
Puglia C, Frasca G, Musumeci T, Rizza L, Puglisi G, Bonina F, Chiechio S. Curcumin loaded NLC induces histone hypoacetylation in the CNS after intraperitoneal administration in mice. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fã¼R Pharmazeutische Verfahrenstechnik E.V. 81: 288-93. PMID 22504443 DOI: 10.1016/J.Ejpb.2012.03.015 |
0.361 |
|
| 2012 |
Chiechio S, Nicoletti F. Metabotropic glutamate receptors and the control of chronic pain. Current Opinion in Pharmacology. 12: 28-34. PMID 22040745 DOI: 10.1016/J.Coph.2011.10.010 |
0.52 |
|
| 2011 |
Spampinato S, Trabucco A, Biasiotta A, Biagioni F, Cruccu G, Copani A, Colledge WH, Sortino MA, Nicoletti F, Chiechio S. Hyperalgesic activity of kisspeptin in mice. Molecular Pain. 7: 90. PMID 22112588 DOI: 10.1186/1744-8069-7-90 |
0.523 |
|
| 2011 |
Zammataro M, Chiechio S, Montana MC, Traficante A, Copani A, Nicoletti F, Gereau RW. mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists. Molecular Pain. 7: 6. PMID 21235748 DOI: 10.1186/1744-8069-7-6 |
0.713 |
|
| 2010 |
Chiechio S, Copani A, Zammataro M, Battaglia G, Gereau RW, Nicoletti F. Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain. Trends in Pharmacological Sciences. 31: 153-60. PMID 20064669 DOI: 10.1016/J.Tips.2009.12.003 |
0.679 |
|
| 2009 |
Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Gereau RW, Copani A, Nicoletti F. Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain. Molecular Pharmacology. 75: 1014-20. PMID 19255242 DOI: 10.1124/Mol.108.054346 |
0.652 |
|
| 2009 |
Chiechio S, Zammataro M, Caraci F, Rampello L, Copani A, Sabato AF, Nicoletti F. Pregabalin in the treatment of chronic pain: an overview. Clinical Drug Investigation. 29: 203-13. PMID 19243212 DOI: 10.2165/00044011-200929030-00006 |
0.469 |
|
| 2009 |
Chiechio S, Zammataro M, Gereau IV RW, Copani A, Nicoletti F. Targeting chronic pain with epigenetic drugs: Focus on mGlu2 receptors Molecular and Cellular Pharmacology. 1: 194-199. DOI: 10.4255/Mcpharmacol.09.23 |
0.53 |
|
| 2007 |
Chiechio S, Copani A, Gereau RW, Nicoletti F. Acetyl-L-carnitine in neuropathic pain: experimental data. Cns Drugs. 21: 31-8; discussion 45-. PMID 17696591 DOI: 10.2165/00023210-200721001-00005 |
0.652 |
|
| 2007 |
Zhao ZQ, Chiechio S, Sun YG, Zhang KH, Zhao CS, Scott M, Johnson RL, Deneris ES, Renner KJ, Gereau RW, Chen ZF. Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6045-53. PMID 17537976 DOI: 10.1523/Jneurosci.1623-07.2007 |
0.629 |
|
| 2006 |
Chiechio S, Copani A, Nicoletti F, Gereau RW. L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies. Current Neuropharmacology. 4: 233-7. PMID 18615142 DOI: 10.2174/157015906778019509 |
0.606 |
|
| 2006 |
Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, Gereau RW, Johnson RL, Deneris ES, Chen ZF. Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12781-8. PMID 17151281 DOI: 10.1523/Jneurosci.4143-06.2006 |
0.527 |
|
| 2006 |
Chiechio S, Copani A, De Petris L, Morales ME, Nicoletti F, Gereau RW. Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine. Molecular Pain. 2: 20. PMID 16764720 DOI: 10.1186/1744-8069-2-20 |
0.595 |
|
| 2004 |
Chiechio S, Copani A, Melchiorri D, Canudas AM, Storto M, Calvani M, Nicolai R, Nicoletti F. Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain. Journal of Endocrinological Investigation. 27: 171-6. PMID 15481819 |
0.424 |
|
| 2003 |
Manahan-Vaughan D, Ngomba RT, Storto M, Kulla A, Catania MV, Chiechio S, Rampello L, Passarelli F, Capece A, Reymann KG, Nicoletti F. An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology. 44: 17-25. PMID 12559118 DOI: 10.1016/S0028-3908(02)00342-8 |
0.358 |
|
| 2002 |
Chiechio S, Caricasole A, Barletta E, Storto M, Catania MV, Copani A, Vertechy M, Nicolai R, Calvani M, Melchiorri D, Nicoletti F. L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors. Molecular Pharmacology. 61: 989-96. PMID 11961116 DOI: 10.1124/Mol.61.5.989 |
0.517 |
|
| 1997 |
Chiechio S, Spadaro C, Arrigo-Reina R. H3-histamine receptors and clonidine analgesia in rats. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 46: S43-4. PMID 9098757 DOI: 10.1007/S000110050054 |
0.332 |
|
| 1995 |
Arrigo-Reina R, Chiechio S. Histaminergic mechanisms in clonidine induced analgesia in rat tail-flick test. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 44: 21-3. PMID 7664025 DOI: 10.1007/Bf01630482 |
0.348 |
|
| 1993 |
Arrigo-Reina R, Chiechio S, Catti T. Increased analgesic potency of morphine following repeated anaphylactoid reaction by compound 48/80 involves cyclooxygenase products of arachidonic acid Agents and Actions. 38: C269-C271. DOI: 10.1007/Bf01996482 |
0.303 |
|
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