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Thomas J. Cradick, Ph.D. - Publications

Affiliations: 
2009 Molecular & Cell Biology University of Iowa, Iowa City, IA 
Area:
General Biology, Molecular Biology, Cell Biology
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Burdo TH, Chen C, Kaminski R, Sariyer IK, Mancuso P, Donadoni M, Smith MD, Sariyer R, Caocci M, Liao S, Liu H, Huo W, Zhao H, Misamore J, Lewis MG, ... ... Cradick TJ, et al. Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates. Gene Therapy. PMID 37587230 DOI: 10.1038/s41434-023-00410-4  0.354
2021 Schneller JL, Lee CM, Venturoni LE, Chandler RJ, Li A, Myung S, Cradick TJ, Hurley AE, Lagor WR, Bao G, Venditti CP. genome editing at the albumin locus to treat methylmalonic acidemia. Molecular Therapy. Methods & Clinical Development. 23: 619-632. PMID 34901307 DOI: 10.1016/j.omtm.2021.11.004  0.449
2018 Antoniani C, Meneghini V, Lattanzi A, Felix T, Romano O, Magrin E, Weber L, Pavani G, El Hoss S, Kurita R, Nakamura Y, Cradick TJ, Lundberg AS, Porteus M, Amendola M, et al. Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus. Blood. PMID 29519807 DOI: 10.1182/Blood-2017-10-811505  0.351
2016 Zhao J, Akinsanmi I, Arafat D, Cradick TJ, Lee CM, Banskota S, Marigorta UM, Bao G, Gibson G. A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood. American Journal of Human Genetics. 98: 299-309. PMID 26849112 DOI: 10.1016/J.Ajhg.2015.12.023  0.37
2016 Lee CM, Cradick TJ, Bao G. The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26782639 DOI: 10.1038/Mt.2016.8  0.606
2016 Lee CM, Cradick TJ, Fine EJ, Bao G. Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26750397 DOI: 10.1038/Mt.2016.1  0.568
2016 Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, ... ... Cradick TJ, et al. TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs. Molecular Therapy. Nucleic Acids. 5: e273. PMID 26730810 DOI: 10.1038/Mtna.2015.43  0.307
2016 Lin MI, Paik EJ, Mishra BP, Chou S, Zhang Y, Tomkinson K, Pettiglio MA, Sanginario A, Woo A, Lee MJ, Allen M, Cradick TJ, Chakraborty T, Porteus M, Lee CM, et al. Re-Creating Hereditary Persistence of Fetal Hemoglobin (HPFH) to Treat Sickle Cell Disease (SCD) and β-Thalassemia Blood. 128: 4708-4708. DOI: 10.1182/Blood.V128.22.4708.4708  0.402
2016 Mishra B, Chou S, Lin MI, Paik EJ, Zhang Y, Liang R, Tomkinson K, Pettiglio M, Sanginario A, Allen M, Cradick T, John M, Chakraborty T, Cowan CA, Novak R, et al. Crispr/Cas9- Mediated Genome Editing of Human CD34+ Cells Upregulate Fetal Hemoglobin to Clinically Relevant Levels in Single Cell-Derived Erythroid Colonies Blood. 128: 3623-3623. DOI: 10.1182/Blood.V128.22.3623.3623  0.415
2016 Antoniani C, Meneghini V, Lattanzi A, Pavani G, Felix T, Amor F, Romano O, Magrin E, Weber L, Cradick T, Lundberg AS, Porteus M, Amendola M, Cavazzana M, Mavilio F, et al. Induction of Fetal Hemoglobin Synthesis By Crispr/Cas9-Mediated Disruption of the β-Globin Locus Architecture Blood. 128: 321-321. DOI: 10.1182/Blood.V128.22.321.321  0.437
2015 Müller M, Lee CM, Gasiunas G, Davis TH, Cradick TJ, Siksnys V, Bao G, Cathomen T, Mussolino C. Streptococcus thermophilus CRISPR-Cas9 systems enable specific editing of the human genome. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26658966 DOI: 10.1038/Mt.2015.218  0.526
2015 Aouida M, Eid A, Ali Z, Cradick T, Lee C, Deshmukh H, Atef A, AbuSamra D, Gadhoum SZ, Merzaban J, Bao G, Mahfouz M. Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering. Plos One. 10: e0133373. PMID 26225561 DOI: 10.1371/Journal.Pone.0133373  0.547
2015 Aouida M, Eid A, Ali Z, Cradick T, Lee C, Deshmukh H, Atef A, Abusamra D, Gadhoum SZ, Merzaban J, Bao G, Mahfouz M. Efficient fdCas9 synthetic endonuclease with improved specificity for precise genome engineering Plos One. 10. DOI: 10.1371/journal.pone.0133373  0.301
2015 Lee C, Bao G, Porteus MH, Cornu T, Miccio A, Cradick T, Cathomen T, Lundberg A, Mavilio F. Gene Editing with Crispr-Cas9 for Treating Beta-Hemoglobinopathies Blood. 126: 3376-3376. DOI: 10.1182/Blood.V126.23.3376.3376  0.48
2015 Lee CM, Cradick TJ, Bao G. 331. Development of Neisseria meningitidis CRISPR/Cas9 Systems for Efficient and Specific Genome Editing Molecular Therapy. 23: S132-S133. DOI: 10.1016/S1525-0016(16)33940-5  0.612
2014 Abarrategui-Pontes C, Créneguy A, Thinard R, Fine EJ, Thepenier V, Fournier le RL, Cradick TJ, Bao G, Tesson L, Podevin G, Anegon I, Nguyen TH. Codon swapping of zinc finger nucleases confers expression in primary cells and in vivo from a single lentiviral vector. Current Gene Therapy. 14: 365-76. PMID 25687502 DOI: 10.2174/156652321405140926161748  0.485
2014 Cradick TJ, Qiu P, Lee CM, Fine EJ, Bao G. COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites. Molecular Therapy. Nucleic Acids. 3: e214. PMID 25462530 DOI: 10.1038/Mtna.2014.64  0.603
2014 Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection. Proceedings of the National Academy of Sciences of the United States of America. 111: 9591-6. PMID 24927590 DOI: 10.1073/Pnas.1407473111  0.379
2014 Lin Y, Cradick TJ, Brown MT, Deshmukh H, Ranjan P, Sarode N, Wile BM, Vertino PM, Stewart FJ, Bao G. CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences. Nucleic Acids Research. 42: 7473-85. PMID 24838573 DOI: 10.1093/Nar/Gku402  0.563
2014 Mussolino C, Alzubi J, Fine EJ, Morbitzer R, Cradick TJ, Lahaye T, Bao G, Cathomen T. TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity. Nucleic Acids Research. 42: 6762-73. PMID 24792154 DOI: 10.1093/Nar/Gku305  0.582
2014 Fine EJ, Cradick TJ, Bao G. Identification of off-target cleavage sites of zinc finger nucleases and TAL effector nucleases using predictive models. Methods in Molecular Biology (Clifton, N.J.). 1114: 371-83. PMID 24557916 DOI: 10.1007/978-1-62703-761-7_24  0.555
2014 Cradick TJ, Antico CJ, Bao G. High-throughput cellular screening of engineered nuclease activity using the single-strand annealing assay and luciferase reporter. Methods in Molecular Biology (Clifton, N.J.). 1114: 339-52. PMID 24557914 DOI: 10.1007/978-1-62703-761-7_22  0.409
2014 Lin Y, Cradick TJ, Bao G. Designing and testing the activities of TAL effector nucleases. Methods in Molecular Biology (Clifton, N.J.). 1114: 203-19. PMID 24557905 DOI: 10.1007/978-1-62703-761-7_13  0.387
2014 Lin Y, Fine EJ, Zheng Z, Antico CJ, Voit RA, Porteus MH, Cradick TJ, Bao G. SAPTA: a new design tool for improving TALE nuclease activity. Nucleic Acids Research. 42: e47. PMID 24442582 DOI: 10.1093/Nar/Gkt1363  0.469
2014 Fine EJ, Cradick TJ, Zhao CL, Lin Y, Bao G. An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage. Nucleic Acids Research. 42: e42. PMID 24381193 DOI: 10.1093/Nar/Gkt1326  0.627
2013 Cradick TJ, Fine EJ, Antico CJ, Bao G. CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Research. 41: 9584-92. PMID 23939622 DOI: 10.1093/Nar/Gkt714  0.538
2013 Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, Cradick TJ, Marraffini LA, Bao G, Zhang F. DNA targeting specificity of RNA-guided Cas9 nucleases. Nature Biotechnology. 31: 827-32. PMID 23873081 DOI: 10.1038/Nbt.2647  0.59
2012 Tong S, Cradick TJ, Ma Y, Dai Z, Bao G. Engineering imaging probes and molecular machines for nanomedicine. Science China. Life Sciences. 55: 843-61. PMID 23108862 DOI: 10.1007/S11427-012-4380-1  0.322
2012 Ramirez CL, Certo MT, Mussolino C, Goodwin MJ, Cradick TJ, McCaffrey AP, Cathomen T, Scharenberg AM, Joung JK. Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Research. 40: 5560-8. PMID 22373919 DOI: 10.1093/Nar/Gks179  0.664
2011 Cradick TJ, Ambrosini G, Iseli C, Bucher P, McCaffrey AP. ZFN-site searches genomes for zinc finger nuclease target sites and off-target sites. Bmc Bioinformatics. 12: 152. PMID 21569489 DOI: 10.1186/1471-2105-12-152  0.68
2010 Cradick TJ, Keck K, Bradshaw S, Jamieson AC, McCaffrey AP. Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 947-54. PMID 20160705 DOI: 10.1038/Mt.2010.20  0.669
2004 Jamieson AC, Cradick TJ, Guan B, Xiao H, Carroll PM. 309. Controlling Embryogenesis Using Engineered Zinc Fingers in Drosophila Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.251  0.307
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