Ricardo Tapia - Publications

Instituto de Fisiologia Celular UNAM, Ciudad de México, Ciudad de México, Mexico 
Epilepsy, neurodegenerative diseases, and neuronal death

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Year Citation  Score
2018 Netzahualcoyotzi C, Tapia R. Tetanus toxin C-fragment protects against excitotoxic spinal motoneuron degeneration in vivo. Scientific Reports. 8: 16584. PMID 30410110 DOI: 10.1038/s41598-018-35027-w  1
2018 Ramírez-Jarquín UN, Tapia R. Excitatory and inhibitory neuronal circuits in the spinal cord and their role in the control of motor neuron function and degeneration. Acs Chemical Neuroscience. PMID 29350907 DOI: 10.1021/acschemneuro.7b00503  0.76
2017 Lazo-Gomez R, Tapia R. Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism. Translational Neurodegeneration. 6: 31. PMID 29201361 DOI: 10.1186/s40035-017-0102-8  0.56
2017 Ramírez-Jarquín UN, Tapia R. Chronic GABAergic blockade in the spinal cord in vivo induces motor alterations and neurodegeneration. Neuropharmacology. PMID 28161374 DOI: 10.1016/j.neuropharm.2017.01.040  0.76
2017 Ramírez-Jarquín UN, Rojas F, van Zundert B, Tapia R. Chronic Infusion of SOD1(G93A) Astrocyte-Secreted Factors Induces Spinal Motoneuron Degeneration and Neuromuscular Dysfunction in Healthy Rats. Journal of Cellular Physiology. PMID 28128448 DOI: 10.1002/jcp.25827  0.76
2016 Ramírez-Jarquín UN, Tapia R. Neuropathological characterization of spinal motor neuron degeneration processes induced by acute and chronic excitotoxic stimulus in vivo. Neuroscience. PMID 27320208 DOI: 10.1016/j.neuroscience.2016.06.021  0.76
2016 Lazo-Gómez R, Tapia R. Motor Alterations Induced by Chronic 4-Aminopyridine Infusion in the Spinal Cord In vivo: Role of Glutamate and GABA Receptors. Frontiers in Neuroscience. 10: 200. PMID 27242406 DOI: 10.3389/fnins.2016.00200  1
2016 Santa-Cruz LD, Guerrero-Castillo S, Uribe-Carvajal S, Tapia R. Mitochondrial dysfunction during the early stages of excitotoxic spinal motor neuron degeneration in vivo. Acs Chemical Neuroscience. PMID 27090876 DOI: 10.1021/acschemneuro.6b00032  0.88
2015 Salazar P, Tapia R. Epilepsy and hippocampal neurodegeneration induced by glutamate decarboxylase inhibitors in awake rats. Epilepsy Research. 116: 27-33. PMID 26354164 DOI: 10.1016/j.eplepsyres.2015.06.014  0.44
2015 Netzahualcoyotzi C, Tapia R. Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates. Acta Neuropathologica Communications. 3: 27. PMID 25968178 DOI: 10.1186/s40478-015-0205-3  1
2015 Salazar P, Tapia R. Epilepsy and hippocampal neurodegeneration induced by glutamate decarboxylase inhibitors in awake rats Epilepsy Research. 116: 27-33. DOI: 10.1016/j.eplepsyres.2015.06.014  1
2014 Netzahualcoyotzi C, Tapia R. Energy substrates protect hippocampus against endogenous glutamate-mediated neurodegeneration in awake rats. Neurochemical Research. 39: 1346-54. PMID 24789366 DOI: 10.1007/s11064-014-1318-y  1
2014 Tovar-Y-Romo LB, Ramírez-Jarquín UN, Lazo-Gómez R, Tapia R. Trophic factors as modulators of motor neuron physiology and survival: implications for ALS therapy. Frontiers in Cellular Neuroscience. 8: 61. PMID 24616665 DOI: 10.3389/fncel.2014.00061  1
2014 Santa-Cruz LD, Tapia R. Role of energy metabolic deficits and oxidative stress in excitotoxic spinal motor neuron degeneration in vivo. Asn Neuro. 6. PMID 24524836 DOI: 10.1042/AN20130046  1
2014 Ramírez-Jarquín UN, Lazo-Gómez R, Tovar-Y-Romo LB, Tapia R. Spinal inhibitory circuits and their role in motor neuron degeneration. Neuropharmacology. 82: 101-7. PMID 24157492 DOI: 10.1016/j.neuropharm.2013.10.003  1
2014 Bardai D, Trim MS, Tapia R, Arias-Correa JA, Baptista-Parra SM. Reservoir evaluation using interval pressure transient test in appraisal gas wells, offshore Trinidad and Tobago Trinidad and Tobago Energy Resources Conference, Spett 2014 - Future Assets: Acquisition, Maintenance and Reliability. 652-666.  0.01
2013 Lazo-Gómez R, Ramírez-Jarquín UN, Tovar-Y-Romo LB, Tapia R. Histone deacetylases and their role in motor neuron degeneration. Frontiers in Cellular Neuroscience. 7: 243. PMID 24367290 DOI: 10.3389/fncel.2013.00243  1
2012 Tovar-y-Romo LB, Tapia R. Delayed administration of VEGF rescues spinal motor neurons from death with a short effective time frame in excitotoxic experimental models in vivo. Asn Neuro. 4. PMID 22369757 DOI: 10.1042/AN20110057  1
2012 Vera G, Tapia R. Activation of group III metabotropic glutamate receptors by endogenous glutamate protects against glutamate-mediated excitotoxicity in the hippocampus in vivo. Journal of Neuroscience Research. 90: 1055-66. PMID 22252898 DOI: 10.1002/jnr.23006  1
2012 Salazar P, Tapia R. Allopregnanolone potentiates the glutamate-mediated seizures induced by 4-aminopyridine in rat hippocampus in vivo. Neurochemical Research. 37: 596-603. PMID 22081320 DOI: 10.1007/s11064-011-0649-1  1
2010 Tovar-Y-Romo LB, Tapia R. VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK. Journal of Neurochemistry. 115: 1090-101. PMID 20456006 DOI: 10.1111/j.1471-4159.2010.06766.x  0.92
2009 Tovar-Y-Romo LB, Santa-Cruz LD, Tapia R. Experimental models for the study of neurodegeneration in amyotrophic lateral sclerosis. Molecular Neurodegeneration. 4: 31. PMID 19619317 DOI: 10.1186/1750-1326-4-31  0.92
2009 Tovar-Y-Romo LB, Santa-Cruz LD, Zepeda A, Tapia R. Chronic elevation of extracellular glutamate due to transport blockade is innocuous for spinal motoneurons in vivo. Neurochemistry International. 54: 186-91. PMID 19100799 DOI: 10.1016/j.neuint.2008.09.015  1
2008 Ayala GX, Tapia R. HSP70 expression protects against hippocampal neurodegeneration induced by endogenous glutamate in vivo. Neuropharmacology. 55: 1383-90. PMID 18789952 DOI: 10.1016/j.neuropharm.2008.08.035  1
2008 Corona JC, Tapia R. Calpain inhibition protects spinal motoneurons from the excitotoxic effects of AMPA in vivo. Neurochemical Research. 33: 1428-34. PMID 18219574 DOI: 10.1007/s11064-007-9559-7  1
2007 Corona JC, Tovar-y-Romo LB, Tapia R. Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis. Expert Opinion On Therapeutic Targets. 11: 1415-28. PMID 18028007 DOI: 10.1517/14728222.11.11.1415  0.92
2007 Tovar-Y-Romo LB, Zepeda A, Tapia R. Vascular endothelial growth factor prevents paralysis and motoneuron death in a rat model of excitotoxic spinal cord neurodegeneration. Journal of Neuropathology and Experimental Neurology. 66: 913-22. PMID 17917585 DOI: 10.1097/nen.0b013e3181567c16  1
2007 Corona JC, Tapia R. Ca2+-permeable AMPA receptors and intracellular Ca2+ determine motoneuron vulnerability in rat spinal cord in vivo. Neuropharmacology. 52: 1219-28. PMID 17320918 DOI: 10.1016/j.neuropharm.2006.12.008  1
2006 Tapia R. Putting the heat on febrile seizures. Nature Medicine. 12: 729-30. PMID 16829913 DOI: 10.1038/nm0706-729  1
2006 Tovar-y-Romo LB, Tapia R. Cerebral neurons of transgenic ALS mice are vulnerable to glutamate release stimulation but not to increased extracellular glutamate due to transport blockade. Experimental Neurology. 199: 281-90. PMID 16364298 DOI: 10.1016/j.expneurol.2005.11.005  0.92
2005 Ayala GX, Tapia R. Late N-methyl-D-aspartate receptor blockade rescues hippocampal neurons from excitotoxic stress and death after 4-aminopyridine-induced epilepsy. The European Journal of Neuroscience. 22: 3067-76. PMID 16367773 DOI: 10.1111/j.1460-9568.2005.04509.x  1
2005 Mora G, Tapia R. Effects of retigabine on the neurodegeneration and extracellular glutamate changes induced by 4-aminopyridine in rat hippocampus in vivo. Neurochemical Research. 30: 1557-65. PMID 16362775 DOI: 10.1007/s11064-005-8834-8  1
2004 Corona JC, Tapia R. AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo. Journal of Neurochemistry. 89: 988-97. PMID 15140197 DOI: 10.1111/j.1471-4159.2004.02383.x  1
2004 Jiménez B, Tapia R. Biochemical modulation of NMDA receptors: role in conditioned taste aversion. Neurochemical Research. 29: 161-8. PMID 14992275 DOI: 10.1023/B:NERE.0000010445.27905.aa  1
2003 Salazar P, Tapia R, Rogawski MA. Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice. Epilepsy Research. 55: 71-82. PMID 12948618 DOI: 10.1016/S0920-1211(03)00112-8  1
2003 Ayala GX, Tapia R. Expression of heat shock protein 70 induced by 4-aminopyridine through glutamate-mediated excitotoxic stress in rat hippocampus in vivo. Neuropharmacology. 45: 649-60. PMID 12941378 DOI: 10.1016/S0028-3908(03)00230-2  1
2003 Velasco I, Velasco-Velázquez MA, Salazar P, Lajud N, Tapia R. Influence of serum-free medium on the expression of glutamate transporters and the susceptibility to glutamate toxicity in cultured cortical neurons. Journal of Neuroscience Research. 71: 811-8. PMID 12605407 DOI: 10.1002/jnr.10538  1
2002 Arias C, Montiel T, Peña F, Ferrera P, Tapia R. Okadaic acid induces epileptic seizures and hyperphosphorylation of the NR2B subunit of the NMDA receptor in rat hippocampus in vivo. Experimental Neurology. 177: 284-91. PMID 12429230 DOI: 10.1006/exnr.2002.7988  1
2002 Velasco I, Tapia R. High extracellular gamma-aminobutyric acid protects cultured neurons against damage induced by the accumulation of endogenous extracellular glutamate. Journal of Neuroscience Research. 67: 406-10. PMID 11813246 DOI: 10.1002/jnr.10114  1
2001 Salazar P, Tapia R. Seizures induced by intracerebral administration of pyridoxal-5'-phosphate: effect of GABAergic drugs and glutamate receptor antagonists. Neuropharmacology. 41: 546-53. PMID 11587709 DOI: 10.1016/S0028-3908(01)00110-1  1
2001 Salazar P, del Carmen Sánchez-Soto M, Hiriart M, Tapia R. Biochemical characteristics of the gamma-aminobutyric acid system in the insulinoma cell lines HIT-T15, RIN-m5F, betaTC3, and comparison with rat brain. Archives of Medical Research. 32: 419-28. PMID 11578757 DOI: 10.1016/S0188-4409(01)00312-5  1
2001 Tapia R. The 2000 Nobel Prize in Medicine or Physiology. Archives of Medical Research. 32: 170-1. PMID 11398775  1
2000 Peña F, Tapia R. Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. Neuroscience. 101: 547-61. PMID 11113304 DOI: 10.1016/S0306-4522(00)00400-0  1
2000 Velasco I, Tapia R. Alterations of intracellular calcium homeostasis and mitochondrial function are involved in ruthenium red neurotoxicity in primary cortical cultures. Journal of Neuroscience Research. 60: 543-51. PMID 10797557 DOI: 10.1002/(SICI)1097-4547(20000515)60:4<543::AID-JNR13>3.0.CO;2-Z  1
1999 Tapia R, Peña F, Arias C. Neurotoxic and synaptic effects of okadaic acid, an inhibitor of protein phosphatases. Neurochemical Research. 24: 1423-30. PMID 10555783 DOI: 10.1023/A:1022588808260  1
1999 Velasco I, Covarrubias M, Tapia R. Injection of Xenopus oocytes with mRNA from cultured neurons induces new currents and susceptibility to the damaging action of ruthenium red. Brain Research Bulletin. 48: 383-6. PMID 10357069 DOI: 10.1016/S0361-9230(99)00010-6  1
1999 Peña F, Tapia R. Relationships among seizures, extracellular amino acid changes, and neurodegeneration induced by 4-aminopyridine in rat hippocampus: a microdialysis and electroencephalographic study. Journal of Neurochemistry. 72: 2006-14. PMID 10217278 DOI: 10.1046/j.1471-4159.1999.0722006.x  1
1998 Pasantes H, Massieu L, Arias C, Tapia R. [Cellular and molecular mechanisms of neurodegeneration]. Gaceta MéDica De MéXico. 134: 685-703. PMID 9927775  1
1998 Arias C, Becerra-García F, Arrieta I, Tapia R. The protein phosphatase inhibitor okadaic acid induces heat shock protein expression and neurodegeneration in rat hippocampus in vivo. Experimental Neurology. 153: 242-54. PMID 9784284 DOI: 10.1006/exnr.1998.6900  1
1998 Arias C, Becerra-García F, Tapia R. Glutamic acid and Alzheimer's disease. Neurobiology (Budapest, Hungary). 6: 33-43. PMID 9713830  1
1997 Arias C, Arrieta I, Massieu L, Tapia R. Neuronal damage and MAP2 changes induced by the glutamate transport inhibitor dihydrokainate and by kainate in rat hippocampus in vivo. Experimental Brain Research. 116: 467-76. PMID 9372295 DOI: 10.1007/PL00005774  1
1997 Massieu L, Tapia R. Glutamate uptake impairment and neuronal damage in young and aged rats in vivo. Journal of Neurochemistry. 69: 1151-60. PMID 9282938  1
1997 Velasco I, Tapia R. Ruthenium red neurotoxicity and interaction with gangliosides in primary cortical cultures. Journal of Neuroscience Research. 49: 72-9. PMID 9211991 DOI: 10.1002/(SICI)1097-4547(19970701)49:1<72::AID-JNR8>3.0.CO;2-A  1
1997 Tapia R, Velasco I. Ruthenium red as a tool to study calcium channels, neuronal death and the function of neural pathways. Neurochemistry International. 30: 137-47. PMID 9017661 DOI: 10.1016/S0197-0186(96)00056-3  1
1996 Tapia R. Release and uptake of glutamate as related to excitotoxicity. Revista Brasileira De Biologia. 56: 165-74. PMID 9394499  1
1996 Velasco I, Tapia R, Massieu L. Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures. Journal of Neuroscience Research. 44: 551-61. PMID 8794946 DOI: 10.1002/(SICI)1097-4547(19960615)44:6<551::AID-JNR5>3.0.CO;2-A  1
1996 Morales-Villagrán A, Tapia R. Preferential stimulation of glutamate release by 4-aminopyridine in rat striatum in vivo. Neurochemistry International. 28: 35-40. PMID 8746762  1
1995 Belmar E, García-Ugalde G, Tapia R. Motor alterations and neuronal damage induced by intracerebral administration of Ruthenium red: effect of NMDA receptor antagonists and other anticonvulsant drugs. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 26: 285-99. PMID 8748930 DOI: 10.1007/BF02815144  1
1995 Jasso-Lopez D, Tapia R. Neurotoxic effect of intranigral injection of 1-methyl-4-phenylpyridinium on GABA-containing neurons and its relation to circling behavior Journal of Neurochemistry. 64: 794-801. PMID 7830073  1
1995 Massieu L, Morales-Villagrán A, Tapia R. Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis study. Journal of Neurochemistry. 64: 2262-72. PMID 7722511  1
1995 Velasco I, Morán J, Tapia R. Selective neurotoxicity of ruthenium red in primary cultures Neurochemical Research. 20: 599-604. PMID 7543979 DOI: 10.1007/BF01694542  1
1995 Arias C, Arrieta I, Tapia R. beta-Amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices. Journal of Neuroscience Research. 41: 561-6. PMID 7473888 DOI: 10.1002/jnr.490410416  1
1994 Massieu L, Rivera A, Tapia R. Convulsions and inhibition of glutamate decarboxylase by pyridoxal phosphate-gamma-glutamyl hydrazone in the developing rat. Neurochemical Research. 19: 183-7. PMID 8183428 DOI: 10.1007/BF00966814  1
1994 Salazar P, Montiel T, Brailowsky S, Tapia R. Decrease of glutamate decarboxylase activity after in vivo cortical infusion of gamma-aminobutyric acid. Neurochemistry International. 24: 363-8. PMID 8061600 DOI: 10.1016/0197-0186(94)90114-7  1
1994 Piña AL, Ormsby CE, Miranda MI, Jiménez N, Tapia R, Bermúdez-Rattoni F. Graft-induced recovery of inhibitory avoidance conditioning in striatal lesioned rats is related to choline acetyltransferase activity. Journal of Neural Transplantation & Plasticity. 5: 11-6. PMID 7819369 DOI: 10.1155/NP.1994.11  1
1994 Massieu L, Tapia R. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline protects against both AMPA and kainate-induced lesions in rat striatum in vivo. Neuroscience. 59: 931-8. PMID 7520137 DOI: 10.1016/0306-4522(94)90296-8  1
1993 Escobar ML, Jiménez N, López-García JC, Tapia R, Bermúdez-Rattoni F. Nerve growth factor with insular cortical grafts induces recovery of learning and reestablishes graft choline acetyltransferase activity. Journal of Neural Transplantation & Plasticity. 4: 167-72. PMID 8110867 DOI: 10.1155/NP.1993.167  1
1993 López-García JC, Fernández-Ruiz J, Escobar ML, Bermúdez-Rattoni F, Tapia R. Effects of excitotoxic lesions of the nucleus basalis magnocellularis on conditioned taste aversion and inhibitory avoidance in the rat. Pharmacology, Biochemistry, and Behavior. 45: 147-52. PMID 8100072 DOI: 10.1016/0091-3057(93)90098-E  1
1992 Arias C, Valero H, Tapia R. Inhibition of brain glutamate decarboxylase activity is related to febrile seizures in rat pups. Journal of Neurochemistry. 58: 369-73. PMID 1727443  1
1992 Fragoso-Veloz J, Tapia R. NMDA receptor antagonists protect against seizures and wet-dog shakes induced by 4-aminopyridine European Journal of Pharmacology. 221: 275-280. PMID 1426006 DOI: 10.1016/0014-2999(92)90713-E  1
1992 Fernández Guardiola A, Tapia R, Brailowsky S, Rodríguez R, Luján M, Ramírez R, Medina M, Capistrán C, Calvo JM, Rocha L. [Experimental models of epilepsy]. Gaceta MéDica De MéXico. 128: 443-60. PMID 1364042  1
1992 Camacho-Arroyo I, Tapia R. Levels, uptake, and release of glycine and glutamate in the rat pontine reticular formation Neurochemical Research. 17: 463-467. PMID 1356245 DOI: 10.1007/BF00969893  1
1992 Bermundez-Rattoni F, Escobar M, Tapia R, Hiriart M. Insular cortical grafts: Factors affecting the recovery of learning Journal of Neural Transplantation and Plasticity. 3: 330-331.  1
1991 Tapia R, Salazar P. Glutamate decarboxylase activity in the substantia nigra and the hippocampus of rats microinjected with inhibitors of the enzyme Neurochemical Research. 16: 263-267. PMID 1780027 DOI: 10.1007/BF00966089  1
1991 García-Ugalde G, Tapia R. Convulsions and wet-dog shakes produced by systemic or intrahippocampal administration of ruthenium red in the rat Experimental Brain Research. 86: 633-640. PMID 1722173 DOI: 10.1007/BF00230537  1
1991 Camacho-Arroyo I, Alvarado R, Tapia R. Release of acetylcholine and GABA, and activity of their synthesizing enzymes in the rat pontine reticular formation Neurochemical Research. 16: 837-841. PMID 1686297 DOI: 10.1007/BF00965530  1
1991 Camacho-Arroyo I, Alvarado R, Manjarrez J, Tapia R. Microinjections of muscimol and bicuculline into the pontine reticular formation modify the sleep-waking cycle in the rat Neuroscience Letters. 129: 95-97. PMID 1656343 DOI: 10.1016/0304-3940(91)90728-C  1
1990 Colotla VA, Flores E, Oscos A, Meneses A, Tapia R. Effects of MPTP on locomotor activity in mice. Neurotoxicology and Teratology. 12: 405-7. PMID 2392101 DOI: 10.1016/0892-0362(90)90061-G  1
1990 Fragoso-Veloz J, Massieu L, Alvarado R, Tapia R. Seizures and wet-dog shakes induced by 4-aminopyridine, and their potentiation by nifedipine. European Journal of Pharmacology. 178: 275-84. PMID 2340861 DOI: 10.1016/0014-2999(90)90106-G  1
1990 López-García JC, Bermúdez-Rattoni F, Tapia R. Release of acetylcholine, gamma-aminobutyrate, dopamine and glutamate, and activity of some related enzymes, in rat gustatory neocortex. Brain Research. 523: 100-4. PMID 2207682 DOI: 10.1016/0006-8993(90)91640-3  1
1990 Arias C, Montiel T, Tapia R. Transmitter release in hippocampal slices from rats with limbic seizures produced by systemic administration of kainic acid. Neurochemical Research. 15: 641-5. PMID 1977092 DOI: 10.1007/BF00973756  1
1990 López-García JC, Fernández-Ruiz J, Bermúdez-Rattoni F, Tapia R. Correlation between acetylcholine release and recovery of conditioned taste aversion induced by fetal neocortex grafts. Brain Research. 523: 105-10. PMID 1976417 DOI: 10.1016/0006-8993(90)91641-S  1
1990 Tapia R, Flores-Hernández J. Circling behavior induced by intranigral administration of ruthenium red and 4-aminopyridine in the rat. Neuroscience. 39: 657-63. PMID 1711171 DOI: 10.1016/0306-4522(90)90250-8  1
1989 Ríos C, Galván-Arzate S, Tapia R. Brain regional thallium distribution in rats acutely intoxicated with Tl2SO4 Archives of Toxicology. 63: 34-37. PMID 2742499 DOI: 10.1007/BF00334631  1
1989 Díaz-Muñoz M, Tapia R. Functional changes of brain mitochondria during experimental hepatic encephalopathy. Biochemical Pharmacology. 38: 3835-41. PMID 2532014 DOI: 10.1016/0006-2952(89)90593-5  1
1989 Tapia R, Salazar C. Chelation of endogenous membrane calcium inhibits γ-aminobutyric acid uptake in synaptosomes Journal of Neuroscience Research. 24: 293-298. PMID 2479766  1
1988 Díaz-Muñoz M, Tapia R. Regional brain GABA metabolism and release during hepatic coma produced in rats chronically treated with carbon tetrachloride. Neurochemical Research. 13: 37-44. PMID 3368028 DOI: 10.1007/BF00971852  1
1988 Díaz-Muñoz M, Tapia R. Glutamate decarboxylase inhibition and vitamin B6 metabolism in brain of cirrhotic rats chronically treated with carbon tetrachloride. Journal of Neuroscience Research. 20: 376-82. PMID 3225873 DOI: 10.1002/jnr.490200311  1
1988 Massieu L, Tapia R. Relationship of dihydropyridine binding sites with calcium-dependent neurotransmitter release in synaptosomes. Journal of Neurochemistry. 51: 1184-9. PMID 2458434  1
1987 Morales E, Tapia R. Neurotransmitters of the cerebellar glomeruli: uptake and release of labeled γ-aminobutyric acid, glycine, serotonin and choline in a purified glomerulus fraction and in granular layer slices Brain Research. 420: 11-21. PMID 3676746 DOI: 10.1016/0006-8993(87)90234-4  1
1987 Ríos C, Tapia R. Changes in lipid peroxidation induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in mouse brain homogenates Neuroscience Letters. 77: 321-326. PMID 3497366 DOI: 10.1016/0304-3940(87)90521-0  1
1986 Arias C, Tapia R. Differential calcium dependence of gamma-aminobutyric acid and acetylcholine release in mouse brain synaptosomes. Journal of Neurochemistry. 47: 396-404. PMID 2426398  1
1985 Tapia R, Sitges M, Morales E. Mechanism of the calcium-dependent stimulation of transmitter release by 4-aminopyridine in synaptosomes Brain Research. 361: 373-382. PMID 2867810 DOI: 10.1016/0006-8993(85)91307-1  1
1985 Tapia R. Effects of drugs on neurotransmitter release: Experiments in vivo and in vitro Neuroscience and Biobehavioral Reviews. 9: 391-397. PMID 2415885 DOI: 10.1016/0149-7634(85)90017-X  1
1985 Tapia R, Arias C, Morales E. Binding of lanthanum ions and ruthenium red to synaptosomes and its effects on neurotransmitter release. Journal of Neurochemistry. 45: 1464-70. PMID 2413171  1
1985 Cassis R, Tapia R, Valderrama JA. Synthesis of 4(1H)-quinolones by thermolysis of arylami nomethylene meldrum's acid derivatives Synthetic Communications. 15: 125-133. DOI: 10.1080/00397918508076818  1
1984 Arias C, Sitges M, Tapia R. Stimulation of [3H]gamma-aminobutyric acid release by calcium chelators in synaptosomes. Journal of Neurochemistry. 42: 1507-14. PMID 6144725  1
1982 Covarrubias M, Tapia R. A procedure for detecting changes in the internal Ca2+ concentration in isolated nerve endings using the metallochromic dye arsenazo III. Neuroscience. 7: 1641-6. PMID 6181431 DOI: 10.1016/0306-4522(82)90022-7  1
1982 Tapia R. Antagonism of the ruthenium red-induced paralysis in mice by 4-aminopyridine, guanidine and lanthanum Neuroscience Letters. 30: 73-77. PMID 6179018  1
1982 Tapia R, Sitges M. Effect of 4-aminopyridine on transmitter release in synaptosomes Brain Research. 250: 291-299. PMID 6129030 DOI: 10.1016/0006-8993(82)90423-1  1
1982 Tapia R, Arias C. Selective stimulation of neurotransmitter release from chick retina by kainic and glutamic acids. Journal of Neurochemistry. 39: 1169-78. PMID 6126522  1
1981 Pérez de la Mora M, Possani LD, Tapia R, Teran L, Palacios R, Fuxe K, Hökfelt T, Ljungdahl A. Demonstration of central gamma-aminobutyrate-containing nerve terminals by means of antibodies against glutamate decarboxylase. Neuroscience. 6: 875-95. PMID 6787456 DOI: 10.1016/0306-4522(81)90169-X  1
1980 Tapia R. Convulsions and the function of GABAergic synapses Progress in Clinical and Biological Research. 123-131. PMID 6893227  1
1980 Covarrubias M, Tapia R. Brain glutamate decarboxylase: properties of its calcium-dependent binding to liposomes and kinetics of the bound and the free enzyme. Journal of Neurochemistry. 34: 1682-8. PMID 6770046  1
1980 Lara R, Tapia R, Cervantes F, Moreno A, Trujillo H. Mathematical model of synaptic plasticity: II. Habituation Neurological Research. 2: 1-18. PMID 6114447  1
1980 Lara R, Tapia R, Cervantes F, Moreno A, Trujillo H. Mathematical model of synaptic plasticity. III. Heterosynaptic changes Neurological Research. 2: 137-152. PMID 6108530  1
1980 Lara R, Tapia R, Cervantes F, Moreno A, Trujillo H. Mathematical models of synaptic plasticity: I. Posttetanic potentiation Neurological Research. 1: 291-304. PMID 6107875  1
1979 López-Colomé AM, Salceda R, Tapia R. Glutamate decarboxylase activity in chick brain and retina. Inhibition of the immature enzyme by Triton-X-100. Neurochemical Research. 4: 567-73. PMID 492446 DOI: 10.1007/BF00964434  1
1979 Tapia R, Drucker-Colín RR, Meza-Ruíz G, Durán L, Levi G. Neurophysiological and neurochemical studies on the action of the anticonvulsant gamma-hydroxy, gamma-ethyl, gamma-phenyl-butyramide. Epilepsia. 20: 135-45. PMID 456334  1
1978 López-Colomé AM, Tapia R, Salceda R, Pasantes-Morales H. K+-stimulated release of labeled gamma-aminobutyrate, glycine and taurine in slices of several regions of rat central nervous system. Neuroscience. 3: 1069-74. PMID 745781 DOI: 10.1016/0306-4522(78)90124-0  1
1978 Covarrubias M, Tapia R. Calcium-dependent binding of brain glutamate decarboxylase to phospholipid vesicles. Journal of Neurochemistry. 31: 1209-14. PMID 702168  1
1978 Meza-Ruiz G, Tapia R. [3H]GABA release in synaptosomal fractions after intracranial administration of ruthenium red. Brain Research. 154: 163-6. PMID 698813 DOI: 10.1016/0006-8993(78)91065-X  1
1978 Bayón A, Possani LD, Rode G, Tapia R. Kinetics of brain glutamate decarboxylase. Dead-end and product inhibition studies Journal of Neurochemistry. 30: 1629-1631. PMID 671008  1
1978 Hökfelt T, Elde R, Fuxe K, Johansson O, Ljungdahl A, Goldstein M, Luft R, Efendic S, Nilsson G, Terenius L, Ganten D, Jeffcoate SL, Rehfeld J, Said S, Perez de la Mora M, ... ... Tapia R, et al. Aminergic and peptidergic pathways in the nervous system with special reference to the hypothalamus. Research Publications - Association For Research in Nervous and Mental Disease. 56: 69-135. PMID 23576  1
1978 Tapia R, Gonzalez RM. Glutamine and glutamate as precursors of the releasable pool of gaba in brain cortex slices Neuroscience Letters. 10: 165-169. DOI: 10.1016/0304-3940(78)90029-0  1
1977 Bayon A, Possani LD, Tapia M, Tapia R. Kinetics of brain glutamate decarboxylase. Interactions with glutamate, pyridoxal 5'-phosphate and glutamate-pyridoxal 5'-phosphate Schiff base Journal of Neurochemistry. 29: 519-525. PMID 894307  1
1977 Bayon A, Possani LD, Tapia R. Kinetics of brain glutamate decarboxylase. Inhibition studies with N-(5'-phosphopyridoxyl) amino acids Journal of Neurochemistry. 29: 513-517. PMID 894306  1
1977 Tapia R, Meza-Ruíz G. Inhibition by ruthenium red of the calcium-dependent release of [3H]GABA in synaptosomal fractions. Brain Research. 126: 160-6. PMID 851889 DOI: 10.1016/0006-8993(77)90223-2  1
1977 Possani LD, Bayón A, Tapia R. Synthesis of affinity chromatography resins for the purification of brain glutamate decarboxylase Neurochemical Research. 2: 51-57. DOI: 10.1007/BF00966021  1
1977 Duran L, Tapia R, Drucker-Colin R. Anticonvulsant action of γ-hydroxy-γ-phenyl caproamide | ACTIVIDAD ANTICONVULSIVANTE DE EL γ-HIDROXI-γ-FENIL-CAPROAMIDA Boletin De Estudios Medicos Y Biologicos. 29: 460-461.  1
1977 Lopez Colome AM, Salceda R, Pasantes-Morales H, Tapia R. Potassium-stimulated release of GABA-H3, glycine-C14 and taurine-S35, in sections from various regions of the CNS of the rat | LIBERACION ESTIMULADA POR [3H], DE GABA [35S], GLICINA [14C] Y TAURINA [35S], EN REBANADAS DE VARIAS REGIONES DEL SNC DE LA RATA Boletin De Estudios Medicos Y Biologicos. 29: 490-491.  1
1976 Tapia R, Meza-Ruíz G. Changes in some properties of glutamate decarboxylase activity during the maturation of the brain. Neurochemical Research. 1: 133-40. PMID 24271337 DOI: 10.1007/BF00966105  1
1976 Sandoval ME, Palacios R, Tapia R. Studies on the relationship between GABA synthesis and protein synthesis in brain Journal of Neurochemistry. 27: 667-672. PMID 966009  1
1976 Tapia R. Evidence for a synthesis-dependent release of GABA Advances in Experimental Medicine and Biology. 69: 385-394. PMID 941743  1
1976 Tapia R, Meza-Ruíz G, Durán L, Drucker-Colín RR. Convulsions or flaccid paralysis induced by ruthenium red depending on route of administration. Brain Research. 116: 101-9. PMID 824018 DOI: 10.1016/0006-8993(76)90251-1  1
1976 Pasantes-Morales H, Mapes C, Tapia R, Mandel P. Properties of soluble and particulate cysteine sulfinate decarboxylase of the adult and the developing rat brain. Brain Research. 107: 575-81. PMID 5179 DOI: 10.1016/0006-8993(76)90145-1  1
1976 Meza Ruis G, Tapia R, Drucker Colin R, Gonzalez RM. 5 Ethyl, 5 phenyl, 2 pyrrolidinone: a possible GABA mimetic anticonvulsant Trans.Amer.Soc.Neurochem.. 7: no. 162.  1
1975 Tapia R, Meza-Ruíz G. Differences in some properties of newborn and adult brain glutamate decarboxylase. Journal of Neurobiology. 6: 171-81. PMID 1185180 DOI: 10.1002/neu.480060205  1
1975 Sandoval ME, Tapia R. GABA metabolism and cerebral protein synthesis Brain Research. 96: 279-286. PMID 1175012 DOI: 10.1016/0006-8993(75)90736-2  1
1975 Tapia R, Sandoval ME, Contreras P. Evidence for a role of glutamate decarboxylase activity as a regulatory mechanism of cerebral excitability Journal of Neurochemistry. 24: 1283-1285. PMID 1127441  1
1975 Balázs R, Hajós F, Johnson AL, Reynierse GL, Tapia R, Wilkin GP. Subcellular fractionation of rat cerebellum: an electron microscopic and biochemical investigation. III. Isolation of large fragments of the cerebellar glomeruli. Brain Research. 86: 17-30. PMID 1115992 DOI: 10.1016/0006-8993(75)90634-4  1
1975 Tapia R, Pasantes-Morales H, Taborda E, Pérez de la Mora M. Seizure susceptibility in the developing mouse and its relationship to glutamate decarboxylase and pyridoxal phosphate in brain. Journal of Neurobiology. 6: 159-70. PMID 171340 DOI: 10.1002/neu.480060204  1
1974 Hajós F, Tapia R, Wilkin G, Johnson AL, Balázs R. Subcellular fractionation of rat cerebellum: an electron microscopic and biochemical investigation. I. Preservation of large fragments of the cerebellar glomeruli. Brain Research. 70: 261-79. PMID 4825673 DOI: 10.1016/0006-8993(74)90316-3  1
1974 Tapia R, Sandoval ME. Possible participation of gamma-aminobutyric acid in the regulation of protein synthesis in brain, in vivo Brain Research. 69: 255-263. PMID 4823094 DOI: 10.1016/0006-8993(74)90005-5  1
1974 Tapia R, Hajós F, Wilkin G, Johnson AL, Balázs R. Subcellular fractionation of rat cerebellum: an electron microscopic and biochemical investigation. II. Resolution of morphologically characterised fractions. Brain Research. 70: 285-99. PMID 4363490 DOI: 10.1016/0006-8993(74)90318-7  1
1974 Sandoval ME, Tapia R. Studies on GABA metabolism and brain protein synthesis Trans.Amer.Soc.Neurochem.. 5: 115.  1
1973 Pérez de la Mora M, Feria-Velasco A, Tapia R. Pyridoxal phosphate and glutamate decarboxylase in subcellular particles of mouse brain and their relationship to convulsions. Journal of Neurochemistry. 20: 1575-87. PMID 4719313  1
1973 de la Mora MP, Tapia R. Anticonvulsant effect of 5-ethyl, 5-phenyl, 2-pyrrolidinone and its possible relationship to γ-aminobutyric acid-dependent inhibitory mechanisms Biochemical Pharmacology. 22: 2635-2639. PMID 4147958 DOI: 10.1016/0006-2952(73)90073-7  1
1972 Balázs R, Hajós F, Michaelson IA, Tapia R, Wilkin G. Isolation of a fraction from rat cerebellum enriched in nerve terminals of one single type (mossy-fibre terminals). The Biochemical Journal. 128: 81P-82P. PMID 4634848  1
1971 Tapia R, Pasantes H. Relationships between pyridoxal phosphate availability, activity of vitamin B6-dependent enzymes and convulsions Brain Research. 29: 111-122. PMID 5564253 DOI: 10.1016/0006-8993(71)90421-5  1
1971 Tapia R, Sandoval ME. Study on the inhibition of brain glutamate decarboxylase by pyridoxal phosphate oxime-O-acetic acid Journal of Neurochemistry. 18: 2051-2059. PMID 4942967  1
1970 Tapia R, Pasantes H, Massieu G. Some properties of glutamate decarboxylase and the content of pyridoxal phosphate in brains of three vertebrate species Journal of Neurochemistry. 17: 921-925. PMID 5426680  1
1969 Tapia R, Awapara J. Effects of various substituted hydrazones and hydrazines of pyridoxal-5'-phosphate on brain glutamate decarboxylase Biochemical Pharmacology. 18: 145-152. PMID 5780984  1
1969 Tapia R, Pérez de la Mora M, Massieu GH. Correlative changes of pyridoxal kinase pyridoxal-5'-phosphate and glutamate decarboxylase in brain, during drug-induced convulsions. Annals of the New York Academy of Sciences. 166: 257-66. PMID 5262020  1
1969 Tapia R, Massieu GH. The role of GABA and related amino acids in some functions of the central nervous system. A review Boletin De Estudios Medicos Y Biologicos. 26: 53-67. PMID 4916454  1
1968 Pérez de la Mora M, Tapia R, Massieu GH. Study on the effect of 3-acetylpyridine on blood glucose concentration. Biochemical Pharmacology. 17: 899-904. PMID 4298434  1
1967 Tapia R, Awapara J. Formation of gamma-aminobutyric acid (GABA) in brain of mice treated with L-glutamic acid-gamma-hydrazide and pyridoxal phosphate-gamma-glutamyl hydrazone Proceedings of the Society For Experimental Biology and Medicine. 126: 218-221. PMID 6066167 DOI: 10.3181/00379727-126-32406  1
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