John Q. Trojanowski, MD,Tufts University, PhD, Tufts University 1976 - Publications

Affiliations: 
Pathology and Laboratory Medicine University of Pennsylvania, Philadelphia, PA, United States 
Area:
Neurodegenerative diseases
Website:
http://pathology.uphs.upenn.edu/Faculty/FacultyInfo.aspx?site=FacultyList&dept=Faculty&id=17800

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Year Citation  Score
2019 Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain : a Journal of Neurology. PMID 31039256 DOI: 10.1093/brain/awz099  0.56
2019 Wu Q, Takano H, Riddle DM, Trojanowski JQ, Coulter DA, Lee VM. Alpha-synuclein (αSyn) preformed fibrils induce endogenous αSyn aggregation, compromise synaptic activity and enhance synapse loss in cultured excitatory hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31036761 DOI: 10.1523/JNEUROSCI.0060-19.2019  0.6
2019 Berson A, Goodman LD, Sartoris AN, Otte CG, Aykit JA, Lee VM, Trojanowski JQ, Bonini NM. Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies. Acta Neuropathologica Communications. 7: 65. PMID 31036086 DOI: 10.1186/s40478-019-0710-x  0.6
2019 Tropea TF, Mak J, Guo MH, Xie SX, Suh E, Rick J, Siderowf A, Weintraub D, Grossman M, Irwin D, Wolk DA, Trojanowski JQ, Van Deerlin V, Chen-Plotkin AS. TMEM106B Effect on Cognition in Parkinson's Disease and Frontotemporal Dementia. Annals of Neurology. PMID 30973966 DOI: 10.1002/ana.25486  0.8
2019 Stewart T, Shi M, Mehrotra A, Aro P, Soltys D, Kerr KF, Zabetian CP, Peskind ER, Taylor P, Shaw LM, Trojanowski JQ, Zhang J. Impact of Pre-Analytical Differences on Biomarkers in the ADNI and PPMI Studies: Implications in the Era of Classifying Disease Based on Biomarkers. Journal of Alzheimer's Disease : Jad. PMID 30958379 DOI: 10.3233/JAD-190069  0.52
2019 Guerreiro R, Escott-Price V, Hernandez DG, Kun-Rodrigues C, Ross OA, Orme T, Neto JL, Carmona S, Dehghani N, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, ... ... Trojanowski JQ, et al. Heritability and genetic variance of dementia with Lewy bodies. Neurobiology of Disease. PMID 30953760 DOI: 10.1016/j.nbd.2019.04.004  0.76
2019 Giannini LA, Xie SX, McMillan CT, Liang M, Williams A, Jester C, Rascovsky K, Wolk DA, Ash S, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. Divergent Patterns of TDP-43 and Tau Pathologies in Primary Progressive Aphasia. Annals of Neurology. PMID 30851133 DOI: 10.1002/ana.25465  0.8
2019 Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, et al. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30846386 DOI: 10.1016/j.jalz.2018.12.019  0.52
2019 Gibbons GS, Kim SJ, Robinson JL, Changolkar L, Irwin DJ, Shaw LM, Lee VM, Trojanowski JQ. Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau). Acta Neuropathologica Communications. 7: 34. PMID 30832741 DOI: 10.1186/s40478-019-0687-5  0.8
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Trojanowski JQ, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.76
2019 Henderson MX, Sengupta M, McGeary I, Zhang B, Olufemi MF, Brown H, Trojanowski JQ, Lee VMY. LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice. Acta Neuropathologica Communications. 7: 28. PMID 30808409 DOI: 10.1186/s40478-019-0679-5  0.76
2019 Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, ... ... Trojanowski JQ, et al. Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology. 18: 231-233. PMID 30784550 DOI: 10.1016/S1474-4422(19)30020-1  0.8
2019 Zhang B, Kehm V, Gathagan R, Leight SN, Trojanowski JQ, Lee VM, Luk KC. Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils. Methods in Molecular Biology (Clifton, N.J.). 1948: 45-57. PMID 30771169 DOI: 10.1007/978-1-4939-9124-2_5  0.6
2019 Karpowicz RJ, Trojanowski JQ, Lee VM. Transmission of α-synuclein seeds in neurodegenerative disease: recent developments. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30760864 DOI: 10.1038/s41374-019-0195-z  0.6
2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, ... ... Trojanowski JQ, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathologica. PMID 30739198 DOI: 10.1007/s00401-019-01962-9  0.8
2019 Smith DH, Johnson VE, Trojanowski JQ, Stewart W. Chronic traumatic encephalopathy - confusion and controversies. Nature Reviews. Neurology. PMID 30664683 DOI: 10.1038/s41582-018-0114-8  0.44
2019 Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Schlepckow K, Caballero MÁA, Franzmeier N, Capell A, Fellerer K, Nuscher B, Eren E, Levin J, Deming Y, Piccio L, Karch CM, Cruchaga C, ... ... Trojanowski JQ, et al. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular Neurodegeneration. 14: 1. PMID 30630532 DOI: 10.1186/s13024-018-0301-5  0.52
2018 Marek K, Chowdhury S, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Simuni T, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, et al. The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort. Annals of Clinical and Translational Neurology. 5: 1460-1477. PMID 30564614 DOI: 10.1002/acn3.644  0.68
2018 Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, ... ... Trojanowski JQ, et al. Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders. Annals of Neurology. PMID 30549331 DOI: 10.1002/ana.25392  0.8
2018 Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, Grossman M, Van Deerlin VM, Trojanowski JQ, et al. Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nature Medicine. PMID 30510257 DOI: 10.1038/s41591-018-0223-3  0.8
2018 Olsson B, Portelius E, Cullen NC, Sandelius Å, Zetterberg H, Andreasson U, Höglund K, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk D, McCluskey L, Elman L, Shaw LM, ... ... Trojanowski JQ, et al. Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders. Jama Neurology. PMID 30508027 DOI: 10.1001/jamaneurol.2018.3746  0.8
2018 Molinuevo JL, Ayton S, Batrla R, Bednar MM, Bittner T, Cummings J, Fagan AM, Hampel H, Mielke MM, Mikulskis A, O'Bryant S, Scheltens P, Sevigny J, Shaw LM, Soares HD, ... ... Trojanowski JQ, et al. Current state of Alzheimer's fluid biomarkers. Acta Neuropathologica. 136: 821-853. PMID 30488277 DOI: 10.1007/s00401-018-1932-x  0.52
2018 Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, ... ... Trojanowski JQ, et al. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. Embo Molecular Medicine. PMID 30482868 DOI: 10.15252/emmm.201809712  0.52
2018 Spiller KJ, Khan T, Dominique MA, Restrepo CR, Cotton-Samuel D, Levitan M, Jafar-Nejad P, Zhang B, Soriano A, Rigo F, Trojanowski JQ, Lee VM. Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice. Neurobiology of Disease. PMID 30458231 DOI: 10.1016/j.nbd.2018.11.013  0.6
2018 Kun-Rodrigues C, Orme T, Carmona S, Hernandez DG, Ross OA, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Dawson T, Rosenthal L, ... ... Trojanowski JQ, et al. A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of Aging. PMID 30448004 DOI: 10.1016/j.neurobiolaging.2018.10.019  0.76
2018 Shaw LM, Waligorska T, Fields L, Korecka M, Figurski M, Trojanowski JQ, Eichenlaub U, Wahl S, Quan M, Pontecorvo MJ, Lachno DR, Talbot JA, Andersen SW, Siemers ER, Dean RA. Derivation of cutoffs for the Elecsys amyloid β (1-42) assay in Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 10: 698-705. PMID 30426066 DOI: 10.1016/j.dadm.2018.07.002  0.52
2018 Zhang B, Yao Y, Cornec AS, Oukoloff K, James MJ, Koivula P, Trojanowski JQ, Smith AB, Lee VM, Ballatore C, Brunden KR. A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. Molecular Neurodegeneration. 13: 59. PMID 30404654 DOI: 10.1186/s13024-018-0291-3  0.6
2018 Al-Janabi OM, Brown CA, Bahrani AA, Abner EL, Barber JM, Gold BT, Goldstein LB, Murphy RR, Nelson PT, Johnson NF, Shaw LM, Smith CD, Trojanowski JQ, Wilcock DM, Jicha GA. Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1 - 42 and Hypertension. Journal of Alzheimer's Disease : Jad. PMID 30400099 DOI: 10.3233/JAD-180663  0.52
2018 Placek K, Baer GM, Elman L, McCluskey L, Hennessy L, Ferraro PM, Lee EB, Lee VMY, Trojanowski JQ, Van Deerlin VM, Grossman M, Irwin DJ, McMillan CT. UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. 73: 190-199. PMID 30368160 DOI: 10.1016/j.neurobiolaging.2018.09.031  0.8
2018 Nho K, Kueider-Paisley A, MahmoudianDehkordi S, Arnold M, Risacher SL, Louie G, Blach C, Baillie R, Han X, Kastenmüller G, Jia W, Xie G, Ahmad S, Hankemeier T, van Duijn CM, ... Trojanowski JQ, et al. Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30337152 DOI: 10.1016/j.jalz.2018.08.012  0.52
2018 MahmoudianDehkordi S, Arnold M, Nho K, Ahmad S, Jia W, Xie G, Louie G, Kueider-Paisley A, Moseley MA, Thompson JW, St John Williams L, Tenenbaum JD, Blach C, Baillie R, Han X, ... ... Trojanowski JQ, et al. Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30337151 DOI: 10.1016/j.jalz.2018.07.217  0.52
2018 Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ, et al. Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30321505 DOI: 10.1016/j.jalz.2018.08.005  0.76
2018 Sandelius Å, Portelius E, Källén Å, Zetterberg H, Rot U, Olsson B, Toledo JB, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, ... ... Trojanowski JQ, et al. Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30321501 DOI: 10.1016/j.jalz.2018.08.006  0.8
2018 Porta S, Xu Y, Restrepo CR, Kwong LK, Zhang B, Brown HJ, Lee EB, Trojanowski JQ, Lee VM. Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo. Nature Communications. 9: 4220. PMID 30310141 DOI: 10.1038/s41467-018-06548-9  0.8
2018 Alcolea D, Irwin DJ, Illán-Gala I, Muñoz L, Clarimón J, McMillan CT, Fortea J, Blesa R, Lee EB, Trojanowski JQ, Grossman M, Lleó A. Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30297518 DOI: 10.1136/jnnp-2018-318993  0.8
2018 Gangishetti U, Christina Howell J, Perrin RJ, Louneva N, Watts KD, Kollhoff A, Grossman M, Wolk DA, Shaw LM, Morris JC, Trojanowski JQ, Fagan AM, Arnold SE, Hu WT. Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease. Alzheimer's Research & Therapy. 10: 98. PMID 30253800 DOI: 10.1186/s13195-018-0426-3  0.8
2018 Brettschneider J, Suh E, Robinson JL, Fang L, Lee EB, Irwin DJ, Grossman M, Van Deerlin VM, Lee VM, Trojanowski JQ. Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy. Journal of Neuropathology and Experimental Neurology. PMID 30203094 DOI: 10.1093/jnen/nly080  0.8
2018 Gibbons GS, Lee VMY, Trojanowski JQ. Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review. Jama Neurology. PMID 30193298 DOI: 10.1001/jamaneurol.2018.2505  0.76
2018 Schmitz M, Villar-Piqué A, Llorens F, Gmitterová K, Hermann P, Varges D, Zafar S, Lingor P, Vanderstichele H, Demeyer L, Stoops E, Trojanowski JQ, Lee VM, Zerr I. Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy. Molecular Neurobiology. PMID 30136097 DOI: 10.1007/s12035-018-1313-4  0.6
2018 McMillan CT, Lee EB, Jefferson-George K, Naj A, Van Deerlin VM, Trojanowski JQ, Wolk DA. Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance? Annals of Clinical and Translational Neurology. 5: 927-934. PMID 30128317 DOI: 10.1002/acn3.581  0.8
2018 Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, Bader DA, Lee VMY, Trojanowski JQ, Liu Z, Sardiello M, Zheng H. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of Experimental Medicine. PMID 30108137 DOI: 10.1084/jem.20172158  0.76
2018 Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, et al. Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30049650 DOI: 10.1016/j.jalz.2018.05.004  0.52
2018 Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, ... ... Trojanowski JQ, et al. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathologica. PMID 29967939 DOI: 10.1007/s00401-018-1881-4  0.8
2018 Robinson JL, Corrada MM, Kovacs GG, Dominique M, Caswell C, Xie SX, Lee VM, Kawas CH, Trojanowski JQ. Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study. Acta Neuropathologica. PMID 29916037 DOI: 10.1007/s00401-018-1872-5  0.6
2018 Kovacs GG, Xie SX, Robinson JL, Lee EB, Smith DH, Schuck T, Lee VM, Trojanowski JQ. Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain. Acta Neuropathologica Communications. 6: 50. PMID 29891013 DOI: 10.1186/s40478-018-0552-y  0.8
2018 Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, ... ... Trojanowski JQ, et al. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a Journal of Neurology. PMID 29878075 DOI: 10.1093/brain/awy146  0.8
2018 Henderson MX, Peng C, Trojanowski JQ, Lee VMY. LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons. Acta Neuropathologica Communications. 6: 45. PMID 29855356 DOI: 10.1186/s40478-018-0550-0  0.76
2018 Oukoloff K, Kovalevich J, Cornec AS, Yao Y, Owyang ZA, James M, Trojanowski JQ, Lee VM, Smith AB, Brunden KR, Ballatore C. Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines. Bioorganic & Medicinal Chemistry Letters. PMID 29764743 DOI: 10.1016/j.bmcl.2018.05.010  0.6
2018 Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM. Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies. Nature. PMID 29743672 DOI: 10.1038/s41586-018-0104-4  0.6
2018 Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, ... ... Trojanowski JQ, et al. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet. Neurology. PMID 29724592 DOI: 10.1016/S1474-4422(18)30126-1  0.8
2018 Portelius E, Olsson B, Höglund K, Cullen NC, Kvartsberg H, Andreasson U, Zetterberg H, Sandelius Å, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, ... ... Trojanowski JQ, et al. Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta Neuropathologica. PMID 29700597 DOI: 10.1007/s00401-018-1851-x  0.8
2018 Roalf DR, Rupert P, Mechanic-Hamilton D, Brennan L, Duda JE, Weintraub D, Trojanowski JQ, Wolk D, Moberg PJ. Quantitative assessment of finger tapping characteristics in mild cognitive impairment, Alzheimer's disease, and Parkinson's disease. Journal of Neurology. PMID 29619565 DOI: 10.1007/s00415-018-8841-8  0.68
2018 Shi M, Tang L, Toledo JB, Ginghina C, Wang H, Aro P, Jensen PH, Weintraub D, Chen-Plotkin AS, Irwin DJ, Grossman M, McCluskey L, Elman LB, Wolk DA, Lee EB, ... ... Trojanowski JQ, et al. Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29604263 DOI: 10.1016/j.jalz.2018.02.015  0.8
2018 Adler DH, Wisse LEM, Ittyerah R, Pluta JB, Ding SL, Xie L, Wang J, Kadivar S, Robinson JL, Schuck T, Trojanowski JQ, Grossman M, Detre JA, Elliott MA, Toledo JB, et al. Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology. Proceedings of the National Academy of Sciences of the United States of America. PMID 29592955 DOI: 10.1073/pnas.1801093115  0.8
2018 Simuni T, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, et al. Longitudinal change of clinical and biological measures in early Parkinson's disease: Parkinson's progression markers initiative cohort. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29572948 DOI: 10.1002/mds.27361  0.68
2018 Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, ... ... Trojanowski JQ, et al. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 97: 1268-1283.e6. PMID 29566793 DOI: 10.1016/j.neuron.2018.02.027  0.8
2018 Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL. Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease. Nature Neuroscience. PMID 29556027 DOI: 10.1038/s41593-018-0124-2  0.52
2018 Lleó A, Irwin DJ, Illán-Gala I, McMillan CT, Wolk DA, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes. Jama Neurology. PMID 29554190 DOI: 10.1001/jamaneurol.2018.0118  0.8
2018 Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL. Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease. Nature Neuroscience. PMID 29507413 DOI: 10.1038/s41593-018-0101-9  0.52
2018 Trombetta BA, Carlyle BC, Koenig AM, Shaw LM, Trojanowski JQ, Wolk DA, Locascio JJ, Arnold SE. The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer's disease. Plos One. 13: e0193707. PMID 29505610 DOI: 10.1371/journal.pone.0193707  0.8
2018 Akhtar RS, Licata JP, Luk KC, Shaw LM, Trojanowski JQ, Lee VM. Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease. Journal of Neurochemistry. PMID 29500813 DOI: 10.1111/jnc.14330  0.6
2018 Hansson O, Seibyl J, Stomrud E, Zetterberg H, Trojanowski JQ, Bittner T, Lifke V, Corradini V, Eichenlaub U, Batrla R, Buck K, Zink K, Rabe C, Blennow K, Shaw LM, et al. CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29499171 DOI: 10.1016/j.jalz.2018.01.010  0.52
2018 Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM, ... ... Trojanowski JQ, et al. CSF tau and amyloid-beta predict cerebral synucleinopathy in autopsied Lewy body disorders. Neurology. PMID 29467305 DOI: 10.1212/WNL.0000000000005166  0.8
2018 Spiller KJ, Restrepo CR, Khan T, Dominique MA, Fang TC, Canter RG, Roberts CJ, Miller KR, Ransohoff RM, Trojanowski JQ, Lee VM. Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy. Nature Neuroscience. PMID 29463850 DOI: 10.1038/s41593-018-0083-7  0.6
2018 Seo SW, Thibodeau MP, Perry DC, Hua A, Sidhu M, Sible I, Vargas JNS, Gaus SE, Rabinovici GD, Rankin KD, Boxer AL, Kramer JH, Rosen HJ, Gorno-Tempini ML, Grinberg LT, ... ... Trojanowski JQ, et al. Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration. Neurology. PMID 29453245 DOI: 10.1212/WNL.0000000000005163  0.52
2018 Gibbons GS, Banks RA, Kim B, Changolkar L, Riddle DM, Leight SN, Irwin DJ, Trojanowski JQ, Lee VMY. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. Journal of Neuropathology and Experimental Neurology. PMID 29415231 DOI: 10.1093/jnen/nly010  0.8
2018 Wang H, Stewart T, Toledo JB, Ginghina C, Tang L, Atik A, Aro P, Shaw LM, Trojanowski JQ, Galasko DR, Edland S, Jensen PH, Shi M, Zhang J. A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment. Journal of Alzheimer's Disease : Jad. 61: 1541-1553. PMID 29376878 DOI: 10.3233/JAD-171013  0.52
2018 Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, ... ... Trojanowski JQ, et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet. Neurology. 17: 64-74. PMID 29263008 DOI: 10.1016/S1474-4422(17)30400-3  0.76
2017 Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre G, Lee EB, Lee VMY, Trojanowski JQ, Grossman M. Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain : a Journal of Neurology. PMID 29228211 DOI: 10.1093/brain/awx319  0.8
2017 Phillips JS, Da Re F, Dratch L, Xie SX, Irwin DJ, McMillan CT, Vaishnavi SN, Ferrarese C, Lee EB, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiology of Aging. 63: 75-87. PMID 29223682 DOI: 10.1016/j.neurobiolaging.2017.11.008  0.8
2017 Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P. Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term. Acta Neuropathologica. PMID 29209768 DOI: 10.1007/s00401-017-1792-9  0.6
2017 He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, ... Trojanowski JQ, et al. Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nature Medicine. PMID 29200205 DOI: 10.1038/nm.4443  0.6
2017 Tropea TF, Xie SX, Rick J, Chahine LM, Dahodwala N, Doshi J, Davatzikos C, Shaw LM, Van Deerlin V, Trojanowski JQ, Weintraub D, Chen-Plotkin AS. APOE, thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29168904 DOI: 10.1002/mds.27204  0.68
2017 Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S, Chung CY, Garcia BA, Lee VM, Trojanowski JQ, Johnson FB, Berger SL, Bonini NM. TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Current Biology : Cb. PMID 29153328 DOI: 10.1016/j.cub.2017.10.024  0.76
2017 Sheinerman KS, Toledo JB, Tsivinsky VG, Irwin D, Grossman M, Weintraub D, Hurtig HI, Chen-Plotkin A, Wolk DA, McCluskey LF, Elman LB, Trojanowski JQ, Umansky SR. Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases. Alzheimer's Research & Therapy. 9: 89. PMID 29121998 DOI: 10.1186/s13195-017-0316-0  0.8
2017 Lewczuk P, Riederer P, O'Bryant SE, Verbeek MM, Dubois B, Visser PJ, Jellinger KA, Engelborghs S, Ramirez A, Parnetti L, Jack CR, Teunissen CE, Hampel H, Lleó A, Jessen F, ... ... Trojanowski JQ, et al. Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-85. PMID 29076399 DOI: 10.1080/15622975.2017.1375556  0.52
2017 Narasimhan S, Guo JL, Changolkar L, Stieber A, McBride JD, Silva LV, He Z, Zhang B, Gathagan RJ, Trojanowski JQ, Lee VMY. Pathological tau strains from human brains recapitulate the diversity of tauopathies in non-transgenic mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29054878 DOI: 10.1523/JNEUROSCI.1230-17.2017  0.76
2017 Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, ... ... Trojanowski JQ, et al. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain : a Journal of Neurology. PMID 29053860 DOI: 10.1093/brain/awx254  0.52
2017 Mollenhauer B, Caspell-Garcia CJ, Coffey CS, Taylor P, Shaw LM, Trojanowski JQ, Singleton A, Frasier M, Marek K, Galasko D. Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls. Neurology. PMID 29030452 DOI: 10.1212/WNL.0000000000004609  0.52
2017 Banks RA, Gibbons GS, Kim B, Xu H, Changolkar L, Leight SN, Riddle DM, Li C, Gathagan RJ, Brown HJ, Zhang B, Trojanowski JQ, Lee VM. GFP-mutant human tau transgenic mice develop tauopathy following CNS injections of Alzheimer's brain-derived pathological tau or synthetic mutant human tau fibrils. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28986461 DOI: 10.1523/JNEUROSCI.2393-17.2017  0.6
2017 Horgusluoglu-Moloch E, Nho K, Risacher SL, Kim S, Foroud T, Shaw LM, Trojanowski JQ, Aisen PS, Petersen RC, Jack CR, Lovestone S, Simmons A, Weiner MW, Saykin AJ. Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 60: 92-103. PMID 28941407 DOI: 10.1016/j.neurobiolaging.2017.08.010  0.52
2017 Deck BL, Rick J, Xie SX, Chen-Plotkin A, Duda JE, Morley JF, Chahine LM, Dahodwala N, Trojanowski JQ, Weintraub D. Statins and Cognition in Parkinson's Disease. Journal of Parkinson's Disease. PMID 28922167 DOI: 10.3233/JPD-171113  0.68
2017 Thakur P, Breger LS, Lundblad M, Wan OW, Mattsson B, Luk KC, Lee VMY, Trojanowski JQ, Björklund A. Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 28900002 DOI: 10.1073/pnas.1710442114  0.76
2017 Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh E, Van Deerlin VM, Grossman M, Lee VM, Trojanowski JQ. Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration. Acta Neuropathologica Communications. 5: 68. PMID 28877758 DOI: 10.1186/s40478-017-0471-3  0.8
2017 Lassalas P, Oukoloff K, Makani V, James M, Tran V, Yao Y, Huang L, Vijayendran K, Monti L, Trojanowski JQ, Lee VM, Kozlowski MC, Smith AB, Brunden KR, Ballatore C. Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group. Acs Medicinal Chemistry Letters. 8: 864-868. PMID 28835803 DOI: 10.1021/acsmedchemlett.7b00212  0.6
2017 Kovacs GG, Lee VM, Trojanowski JQ. Protein astrogliopathies in human neurodegenerative diseases and aging. Brain Pathology (Zurich, Switzerland). 27: 675-690. PMID 28805003 DOI: 10.1111/bpa.12536  0.6
2017 Kovacs GG, Yousef A, Kaindl S, Lee VM, Trojanowski JQ. Connexin-43 and Aquaporin-4 are markers of ARTAG-related astroglial response. Neuropathology and Applied Neurobiology. PMID 28755467 DOI: 10.1111/nan.12427  0.6
2017 Gold BT, Brown CA, Hakun JG, Shaw LM, Trojanowski JQ, Smith CD. Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults. Neurobiology of Aging. 58: 102-111. PMID 28719854 DOI: 10.1016/j.neurobiolaging.2017.06.012  0.52
2017 Irwin DJ, Lleó A, Xie SX, McMillan CT, Wolk D, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD. Annals of Neurology. PMID 28719018 DOI: 10.1002/ana.24996  0.8
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Trojanowski JQ, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/ng.3916  0.8
2017 Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron. PMID 28669544 DOI: 10.1016/j.neuron.2017.05.037  0.8
2017 Gendron TF, Daughrity LM, Heckman MG, Diehl NN, Wuu J, Miller TM, Pastor P, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Benatar M, Silani V, Glass JD, et al. Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis. Annals of Neurology. PMID 28628244 DOI: 10.1002/ana.24980  0.8
2017 McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, ... ... Trojanowski JQ, et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. PMID 28592453 DOI: 10.1212/WNL.0000000000004058  0.76
2017 Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, ... ... Trojanowski JQ, et al. Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of Neuropathology and Experimental Neurology. PMID 28591867 DOI: 10.1093/jnen/nlx041  0.8
2017 Nho K, Kim S, Horgusluoglu E, Risacher SL, Shen L, Kim D, Lee S, Foroud T, Shaw LM, Trojanowski JQ, Aisen PS, Petersen RC, Jack CR, Weiner MW, Green RC, et al. Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease. Bmc Medical Genomics. 10: 29. PMID 28589856 DOI: 10.1186/s12920-017-0267-0  0.52
2017 Deters KD, Risacher SL, Kim S, Nho K, West JD, Blennow K, Zetterberg H, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ. Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 28550246 DOI: 10.3233/JAD-161114  0.52
2017 Akhtar RS, Xie SX, Chen YJ, Rick J, Gross RG, Nasrallah IM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS, Hurtig HI, Siderowf AD, Dubroff JG, Weintraub D. Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia. Plos One. 12: e0177924. PMID 28542444 DOI: 10.1371/journal.pone.0177924  0.8
2017 Cornec AS, Monti L, Kovalevich J, Makani V, James MJ, Vijayendran KG, Oukoloff K, Yao Y, Lee VM, Trojanowski JQ, Smith Iii AB, Brunden KR, Ballatore C. Multi-targeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases. Journal of Medicinal Chemistry. PMID 28530811 DOI: 10.1021/acs.jmedchem.7b00475  0.6
2017 Mata IF, Johnson CO, Leverenz JB, Weintraub D, Trojanowski JQ, Van Deerlin VM, Ritz B, Rausch R, Factor SA, Wood-Siverio C, Quinn JF, Chung KA, Peterson-Hiller AL, Espay AJ, Revilla FJ, et al. Large-scale exploratory genetic analysis of cognitive impairment in Parkinson's disease. Neurobiology of Aging. PMID 28526295 DOI: 10.1016/j.neurobiolaging.2017.04.009  0.8
2017 Henderson MX, Chung CH, Riddle DM, Zhang B, Gathagan RJ, Seeholzer SH, Trojanowski JQ, Lee VMY. Unbiased proteomics of early Lewy body formation model implicates active microtubule affinity-regulating kinases (MARKs) in synucleinopathies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28522732 DOI: 10.1523/JNEUROSCI.2705-16.2017  0.76
2017 Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, et al. Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease. Plos One. 12: e0175674. PMID 28520803 DOI: 10.1371/journal.pone.0175674  0.68
2017 Giannini LAA, Irwin DJ, McMillan CT, Ash S, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, Trojanowski JQ, Grossman M. Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia. Neurology. PMID 28515265 DOI: 10.1212/WNL.0000000000004034  0.8
2017 Brennan L, Devlin KM, Xie SX, Mechanic-Hamilton D, Tran B, Hurtig HH, Chen-Plotkin A, Chahine LM, Morley JF, Duda JE, Roalf DR, Dahodwala N, Rick J, Trojanowski JQ, Moberg PJ, et al. Neuropsychological Subgroups in Non-Demented Parkinson's Disease: A Latent Class Analysis. Journal of Parkinson's Disease. PMID 28387684 DOI: 10.3233/JPD-171081  0.68
2017 Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, Lee VM. Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease. Neuropathology and Applied Neurobiology. PMID 28386933 DOI: 10.1111/nan.12402  0.8
2017 Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, ... ... Trojanowski JQ, et al. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science Translational Medicine. 9. PMID 28356511 DOI: 10.1126/scitranslmed.aai7866  0.8
2017 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ, et al. Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28342697 DOI: 10.1016/j.jalz.2016.11.007  0.76
2017 Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, ... ... Trojanowski JQ, et al. Metabolic network failures in Alzheimer's disease-A biochemical road map. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28341160 DOI: 10.1016/j.jalz.2017.01.020  0.52
2017 Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, ... Trojanowski JQ, et al. Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. Journal of Neuropathology and Experimental Neurology. PMID 28340083 DOI: 10.1093/jnen/nlx007  0.8
2017 Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, ... ... Trojanowski JQ, et al. Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta Neuropathologica. PMID 28247064 DOI: 10.1007/s00401-017-1685-y  0.8
2017 Sposato LA, Ruíz Vargas E, Riccio PM, Toledo JB, Trojanowski JQ, Kukull WA, Cipriano LE, Nucera A, Whitehead SN, Hachinski V. Milder Alzheimer's disease pathology in heart failure and atrial fibrillation. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28174071 DOI: 10.1016/j.jalz.2016.12.002  0.52
2017 Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, et al. Typical and atypical pathology in primary progressive aphasia variants. Annals of Neurology. PMID 28133816 DOI: 10.1002/ana.24885  0.52
2017 Lee EB, Porta S, Michael Baer G, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM, Irwin DJ, Van Deerlin VM, Trojanowski JQ. Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration. Acta Neuropathologica. PMID 28130640 DOI: 10.1007/s00401-017-1679-9  0.8
2017 Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB. Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies. Acs Chemical Neuroscience. 8: 5-7. PMID 28095679 DOI: 10.1021/acschemneuro.6b00384  0.6
2017 Ono M, Sahara N, Kumata K, Ji B, Ni R, Koga S, Dickson DW, Trojanowski JQ, Lee VM, Yoshida M, Hozumi I, Yoshiyama Y, van Swieten JC, Nordberg A, Suhara T, et al. Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain : a Journal of Neurology. PMID 28087578 DOI: 10.1093/brain/aww339  0.6
2017 Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, ... ... Trojanowski JQ, et al. Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. The Lancet. Neurology. 16: 55-65. PMID 27979356 DOI: 10.1016/S1474-4422(16)30291-5  0.8
2017 Brown CA, Johnson NF, Anderson-Mooney AJ, Jicha GA, Shaw LM, Trojanowski JQ, Van Eldik LJ, Schmitt FA, Smith CD, Gold BT. Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease. Neuroimage. Clinical. 13: 106-115. PMID 27942453 DOI: 10.1016/j.nicl.2016.11.024  0.52
2016 Yushkevich PA, Wisse L, Adler D, Ittyerah R, Pluta JB, Robinson JL, Schuck T, Trojanowski JQ, Grossman M, Detre JA, Elliott MA, Toledo JB, Weixia Liu, Pickup S, Das SR, et al. A framework for informing segmentation of in vivo MRI with information derived from ex vivo imaging: Application in the medial temporal lobe. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2016: 6014-6017. PMID 28269623 DOI: 10.1109/EMBC.2016.7592099  0.8
2016 Yushkevich PA, Wisse L, Adler D, Ittyerah R, Pluta JB, Robinson JL, Schuck T, Trojanowski JQ, Grossman M, Detre JA, Elliott MA, Toledo JB, Liu W, Pickup S, Das SR, ... ... Trojanowski JQ, ... ... Trojanowski JQ, et al. A framework for informing segmentation of in vivo MRI with information derived from ex vivo imaging: Application in the medial temporal lobe. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2016: 6014-6017. PMID 28227881 DOI: 10.1109/EMBC.2016.7592099  0.8
2016 Spotorno N, McMillan CT, Irwin DJ, Clark R, Lee EB, Trojanowski JQ, Weintraub D, Grossman M. Decision-Making Deficits Associated with Amyloidosis in Lewy Body Disorders. Frontiers in Human Neuroscience. 10: 693. PMID 28123364 DOI: 10.3389/fnhum.2016.00693  0.8
2016 Kovacs GG, Kwong LK, Grossman M, Irwin DJ, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain Pathology (Zurich, Switzerland). PMID 28019685 DOI: 10.1111/bpa.12482  0.8
2016 Brunden KR, Lee VM, Smith AB, Trojanowski JQ, Ballatore C. Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs. Neurobiology of Disease. PMID 28012891 DOI: 10.1016/j.nbd.2016.12.021  0.6
2016 Dong A, Toledo JB, Honnorat N, Doshi J, Varol E, Sotiras A, Wolk D, Trojanowski JQ, Davatzikos C. Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers. Brain : a Journal of Neurology. PMID 28003242 DOI: 10.1093/brain/aww319  0.52
2016 Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JS, Leroux F, Herledan A, Demiautte F, ... ... Trojanowski JQ, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathologica. PMID 27933404 DOI: 10.1007/s00401-016-1652-z  0.8
2016 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Morris JC, Petersen RC, Salazar J, Saykin AJ, Shaw LM, Toga AW, ... Trojanowski JQ, et al. The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27931796 DOI: 10.1016/j.jalz.2016.10.006  0.76
2016 McMillan CT, Irwin DJ, Nasrallah I, Phillips JS, Spindler M, Rascovsky K, Ternes K, Jester C, Wolk DA, Kwong LK, Lee VM, Lee EB, Trojanowski JQ, Grossman M. Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. Acta Neuropathologica. PMID 27815633 DOI: 10.1007/s00401-016-1640-3  0.8
2016 Guo JL, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VM. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. The Journal of Experimental Medicine. PMID 27810929 DOI: 10.1084/jem.20160833  0.6
2016 Khanna MR, Kovalevich J, Lee VM, Trojanowski JQ, Brunden KR. Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 1051-1065. PMID 27751442 DOI: 10.1016/j.jalz.2016.06.006  0.6
2016 Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, et al. Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. Scientific Reports. 6: 34904. PMID 27721502 DOI: 10.1038/srep34904  0.6
2016 Brettschneider J, Irwin DJ, Boluda S, Byrne MD, Fang L, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Toledo JB, Grossman M, Hurtig H, Dengler R, Petri S, Lee VM, ... Trojanowski JQ, et al. Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type. Neuropathology and Applied Neurobiology. PMID 27716988 DOI: 10.1111/nan.12362  0.8
2016 Mattsson N, Zetterberg H, Janelidze S, Insel PS, Andreasson U, Stomrud E, Palmqvist S, Baker D, Tan Hehir CA, Jeromin A, Hanlon D, Song L, Shaw LM, Trojanowski JQ, Weiner MW, et al. Plasma tau in Alzheimer disease. Neurology. PMID 27694257 DOI: 10.1212/WNL.0000000000003246  0.52
2016 Makani V, Zhang B, Han H, Yao Y, Lassalas P, Lou K, Paterson I, Lee VM, Trojanowski JQ, Ballatore C, Smith AB, Brunden KR. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathologica Communications. 4: 106. PMID 27687527 DOI: 10.1186/s40478-016-0378-4  0.6
2016 Spiller KJ, Restrepo CR, Khan T, Stieber AM, Kwong LK, Trojanowski JQ, Lee VM. Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice. Acta Neuropathologica Communications. 4: 105. PMID 27687289 DOI: 10.1186/s40478-016-0377-5  0.76
2016 Placek K, Massimo L, Olm C, Ternes K, Firn K, Van Deerlin V, Lee EB, Trojanowski JQ, Lee VM, Irwin D, Grossman M, McMillan CT. Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence. Neurology. PMID 27683847 DOI: 10.1212/WNL.0000000000003250  0.8
2016 Kun-Rodrigues C, Ross OA, Orme T, Shepherd C, Parkkinen L, Darwent L, Hernandez D, Ansorge O, Clark LN, Honig LS, Marder K, Lemstra A, Scheltens P, van der Flier W, Louwersheimer E, ... ... Trojanowski JQ, et al. Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies. Neurobiology of Aging. PMID 27666590 DOI: 10.1016/j.neurobiolaging.2016.08.023  0.76
2016 Luk KC, Covell DJ, Kehm VM, Zhang B, Song IY, Byrne MD, Pitkin RM, Decker SC, Trojanowski JQ, Lee VM. Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity. Cell Reports. 16: 3373-87. PMID 27653697 DOI: 10.1016/j.celrep.2016.08.053  0.6
2016 Davis MY, Johnson CO, Leverenz JB, Weintraub D, Trojanowski JQ, Chen-Plotkin A, Van Deerlin VM, Quinn JF, Chung KA, Peterson-Hiller AL, Rosenthal LS, Dawson TM, Albert MS, Goldman JG, Stebbins GT, et al. Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease. Jama Neurology. PMID 27571329 DOI: 10.1001/jamaneurol.2016.2245  0.8
2016 McMillan CT, Boyd C, Gross RG, Weinstein J, Firn K, Toledo JB, Rascovsky K, Shaw L, Wolk DA, Irwin DJ, Lee EB, Trojanowski JQ, Grossman M. Multimodal imaging evidence of pathology-mediated disease distribution in corticobasal syndrome. Neurology. PMID 27543644 DOI: 10.1212/WNL.0000000000003119  0.6
2016 Nho K, Horgusluoglu E, Kim S, Risacher SL, Kim D, Foroud T, Aisen PS, Petersen RC, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW, Green RC, Toga AW, Saykin AJ, et al. Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer's disease. Bmc Medical Genomics. 9: 30. PMID 27535542 DOI: 10.1186/s12920-016-0190-9  0.76
2016 Rey NL, Steiner JA, Maroof N, Luk KC, Madaj Z, Trojanowski JQ, Lee VM, Brundin P. Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease. The Journal of Experimental Medicine. PMID 27503075 DOI: 10.1084/jem.20160368  0.6
2016 Akhtar RS, Xie SX, Brennan L, Pontecorvo MJ, Hurtig HI, Trojanowski JQ, Weintraub D, Siderowf AD. Amyloid-Beta Positron Emission Tomography Imaging of Alzheimer's Pathology in Parkinson's Disease Dementia. Movement Disorders Clinical Practice. 3: 367-375. PMID 27500181 DOI: 10.1002/mdc3.12290  0.68
2016 Durazzo TC, Korecka M, Trojanowski JQ, Weiner MW, O' Hara R, Ashford JW, Shaw LM. Active Cigarette Smoking in Cognitively-Normal Elders and Probable Alzheimer's Disease is Associated with Elevated Cerebrospinal Fluid Oxidative Stress Biomarkers. Journal of Alzheimer's Disease : Jad. PMID 27472882 DOI: 10.3233/JAD-160413  0.52
2016 van Rheenen W, Shatunov A, Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RA, Võsa U, de Jong S, Robinson MR, Yang J, Fogh I, van Doormaal PT, Tazelaar GH, Koppers M, ... ... Trojanowski JQ, et al. Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nature Genetics. 48: 1043-8. PMID 27455348 DOI: 10.1038/ng.3622  0.8
2016 Spiller KJ, Cheung CJ, Restrepo CR, Kwong LK, Stieber AM, Trojanowski JQ, Lee VM. Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7707-17. PMID 27445147 DOI: 10.1523/JNEUROSCI.1457-16.2016  0.76
2016 Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovičić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, ... ... Trojanowski JQ, et al. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. PMID 27321923 DOI: 10.1016/j.neuron.2016.05.021  0.68
2016 Abner EL, Jicha GA, Shaw LM, Trojanowski JQ, Goetzl EJ. Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging. Annals of Clinical and Translational Neurology. 3: 399-403. PMID 27231710 DOI: 10.1002/acn3.309  0.52
2016 Lim NS, Swanson CR, Cherng HR, Unger TL, Xie SX, Weintraub D, Marek K, Stern MB, Siderowf A, Trojanowski JQ, Chen-Plotkin AS. Plasma EGF and cognitive decline in Parkinson's disease and Alzheimer's disease. Annals of Clinical and Translational Neurology. 3: 346-55. PMID 27231704 DOI: 10.1002/acn3.299  0.68
2016 Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET. "New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS). Journal of Neuropathology and Experimental Neurology. PMID 27209644 DOI: 10.1093/jnen/nlw033  0.6
2016 Santos-Santos MA, Mandelli ML, Binney RJ, Ogar J, Wilson SM, Henry ML, Hubbard HI, Meese M, Attygalle S, Rosenberg L, Pakvasa M, Trojanowski JQ, Grinberg LT, Rosen H, Boxer AL, et al. Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. Jama Neurology. PMID 27111692 DOI: 10.1001/jamaneurol.2016.0412  0.52
2016 Kang JH, Mollenhauer B, Coffey CS, Toledo JB, Weintraub D, Galasko DR, Irwin DJ, Van Deerlin V, Chen-Plotkin AS, Caspell-Garcia C, Waligórska T, Taylor P, Shah N, Pan S, Zero P, ... ... Trojanowski JQ, et al. CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study. Acta Neuropathologica. PMID 27021906 DOI: 10.1007/s00401-016-1552-2  0.68
2016 Kovalevich J, Cornec AS, Yao Y, James M, Crowe A, Lee VM, Trojanowski JQ, Smith AB, Ballatore C, Brunden KR. Characterization of brain-penetrant pyrimidine-containing molecules with differential microtubule-stabilizing activities developed as potential therapeutic agents for Alzheimer's disease and related tauopathies. The Journal of Pharmacology and Experimental Therapeutics. PMID 26980057 DOI: 10.1124/jpet.115.231175  0.6
2016 Brennan L, Siderowf A, Rubright JD, Rick J, Dahodwala N, Duda JE, Hurtig H, Stern M, Xie SX, Rennert L, Karlawish J, Shea JA, Trojanowski JQ, Weintraub D. The Penn Parkinson's Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson's disease. Parkinsonism & Related Disorders. PMID 26923524 DOI: 10.1016/j.parkreldis.2016.02.020  0.6
2016 Berlyand Y, Weintraub D, Xie SX, Mellis IA, Doshi J, Rick J, McBride J, Davatzikos C, Shaw LM, Hurtig H, Trojanowski JQ, Chen-Plotkin AS. An Alzheimer's Disease-Derived Biomarker Signature Identifies Parkinson's Disease Patients with Dementia. Plos One. 11: e0147319. PMID 26812251 DOI: 10.1371/journal.pone.0147319  0.6
2015 Lazaris A, Hwang KS, Goukasian N, Ramirez LM, Eastman J, Blanken AE, Teng E, Gylys K, Cole G, Saykin AJ, Shaw LM, Trojanowski JQ, Jagust WJ, Weiner MW, Apostolova LG, et al. Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding. Neurology. Genetics. 1: e22. PMID 27066559 DOI: 10.1212/NXG.0000000000000022  0.52
2015 Toledo JB, Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, ... ... Trojanowski JQ, et al. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathologica. PMID 26721587 DOI: 10.1007/s00401-015-1526-9  0.52
2015 Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, ... ... Trojanowski JQ, et al. Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study. Alzheimer's & Dementia (Amsterdam, Netherlands). 1: 339-348. PMID 26693175 DOI: 10.1016/j.dadm.2015.06.008  0.8
2015 Lewczuk P, Kornhuber J, Toledo JB, Trojanowski JQ, Knapik-Czajka M, Peters O, Wiltfang J, Shaw LM. Validation of the Erlangen Score Algorithm for the Prediction of the Development of Dementia due to Alzheimer's Disease in Pre-Dementia Subjects. Journal of Alzheimer's Disease : Jad. 49: 887. PMID 26682863 DOI: 10.3233/JAD-159006  0.52
2015 Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, ... ... Trojanowski JQ, et al. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica. PMID 26659578 DOI: 10.1007/s00401-015-1509-x  0.8
2015 Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM, Grossman M, Trojanowski JQ. Deep Clinical and Neuropathological Phenotyping of Pick's Disease. Annals of Neurology. PMID 26583316 DOI: 10.1002/ana.24559  0.52
2015 Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ. Semi-Automated Digital Image Analysis of Pick's Disease and TDP-3 Proteinopathy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. PMID 26538548 DOI: 10.1369/0022155415614303  0.68
2015 Zetterberg H, Skillbäck T, Mattsson N, Trojanowski JQ, Portelius E, Shaw LM, Weiner MW, Blennow K. Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression. Jama Neurology. 1-8. PMID 26524180 DOI: 10.1001/jamaneurol.2015.3037  0.6
2015 Amlie-Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, Van Deerlin VM, Gregory BD, Kwong LK, Trojanowski JQ, Lee VM, Wang LS, Lee EB. Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin. Plos One. 10: e0141836. PMID 26510133 DOI: 10.1371/journal.pone.0141836  0.68
2015 Walker AK, Tripathy K, Restrepo CR, Ge G, Xu Y, Kwong LK, Trojanowski JQ, Lee VM. An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Human Molecular Genetics. PMID 26476406 DOI: 10.1093/hmg/ddv424  0.68
2015 Bilello M, Doshi J, Nabavizadeh SA, Toledo JB, Erus G, Xie SX, Trojanowski JQ, Han X, Davatzikos C. Correlating Cognitive Decline with White Matter Lesion and Brain Atrophy Magnetic Resonance Imaging Measurements in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26402108 DOI: 10.3233/JAD-150400  0.52
2015 Lewczuk P, Kornhuber J, Toledo JB, Trojanowski JQ, Knapik-Czajka M, Peters O, Wiltfang J, Shaw LM. Validation of the Erlangen Score Algorithm for the Prediction of the Development of Dementia due to Alzheimer's Disease in Pre-Dementia Subjects. Journal of Alzheimer's Disease : Jad. 48: 433-41. PMID 26402007 DOI: 10.3233/JAD-150342  0.76
2015 Portelius E, Zetterberg H, Skillbäck T, Törnqvist U, Andreasson U, Trojanowski JQ, Weiner MW, Shaw LM, Mattsson N, Blennow K. Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease. Brain : a Journal of Neurology. PMID 26373605 DOI: 10.1093/brain/awv267  0.6
2015 Pigott K, Rick J, Xie SX, Hurtig H, Chen-Plotkin A, Duda JE, Morley JF, Chahine LM, Dahodwala N, Akhtar RS, Siderowf A, Trojanowski JQ, Weintraub D. Longitudinal study of normal cognition in Parkinson disease. Neurology. PMID 26362285 DOI: 10.1212/WNL.0000000000002001  0.68
2015 Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, ... Trojanowski JQ, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26327235 DOI: 10.1016/j.jalz.2015.07.492  0.8
2015 Mata IF, Leverenz JB, Weintraub D, Trojanowski JQ, Chen-Plotkin A, Van Deerlin VM, Ritz B, Rausch R, Factor SA, Wood-Siverio C, Quinn JF, Chung KA, Peterson-Hiller AL, Goldman JG, Stebbins GT, et al. GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26296077 DOI: 10.1002/mds.26359  0.8
2015 Brennan L, Siderowf A, Rubright JD, Rick J, Dahodwala N, Duda JE, Hurtig H, Stern M, Xie SX, Rennert L, Karlawish J, Shea JA, Trojanowski JQ, Weintraub D. Development and initial testing of the Penn Parkinson's Daily Activities Questionnaire. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26249849 DOI: 10.1002/mds.26339  0.68
2015 Toledo JB, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, ... ... Trojanowski JQ, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a Journal of Neurology. 138: 2701-15. PMID 26220940 DOI: 10.1093/brain/awv199  0.56
2015 Torralva T, Sposato LA, Riccio PM, Gleichgerrcht E, Roca M, Toledo JB, Trojanowski JQ, Kukull WA, Manes F, Hachinski V. Role of brain infarcts in behavioral variant frontotemporal dementia: Clinicopathological characterization in the National Alzheimer's Coordinating Center database. Neurobiology of Aging. 36: 2861-8. PMID 26220367 DOI: 10.1016/j.neurobiolaging.2015.06.026  0.52
2015 Walker AK, Spiller KJ, Ge G, Zheng A, Xu Y, Zhou M, Tripathy K, Kwong LK, Trojanowski JQ, Lee VM. Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. Acta Neuropathologica. PMID 26197969 DOI: 10.1007/s00401-015-1460-x  0.76
2015 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Donohue MC, Green RC, Harvey D, Jack CR, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw L, ... ... Trojanowski JQ, et al. Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 865-84. PMID 26194320 DOI: 10.1016/j.jalz.2015.04.005  0.76
2015 Kang JH, Korecka M, Figurski MJ, Toledo JB, Blennow K, Zetterberg H, Waligorska T, Brylska M, Fields L, Shah N, Soares H, Dean RA, Vanderstichele H, Petersen RC, Aisen PS, ... ... Trojanowski JQ, et al. The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 772-91. PMID 26194312 DOI: 10.1016/j.jalz.2015.05.003  0.76
2015 Iba M, McBride JD, Guo JL, Zhang B, Trojanowski JQ, Lee VM. Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections. Acta Neuropathologica. PMID 26150341 DOI: 10.1007/s00401-015-1458-4  0.76
2015 Robinson JL, Suh E, Wood EM, Lee EB, Coslett HB, Raible K, Lee VM, Trojanowski JQ, Van Deerlin VM. Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His. Acta Neuropathologica Communications. 3: 42. PMID 26141825 DOI: 10.1186/s40478-015-0219-x  0.8
2015 Fitts W, Weintraub D, Massimo L, Chahine L, Chen-Plotkin A, Duda JE, Hurtig HI, Rick J, Trojanowski JQ, Dahodwala N. Caregiver report of apathy predicts dementia in Parkinson's disease. Parkinsonism & Related Disorders. 21: 992-5. PMID 26117435 DOI: 10.1016/j.parkreldis.2015.06.009  0.68
2015 Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of Disease. 82: 185-199. PMID 26093169 DOI: 10.1016/j.nbd.2015.06.003  0.76
2015 Toledo JB, Bjerke M, Chen K, Rozycki M, Jack CR, Weiner MW, Arnold SE, Reiman EM, Davatzikos C, Shaw LM, Trojanowski JQ. Memory, executive, and multidomain subtle cognitive impairment: Clinical and biomarker findings. Neurology. 85: 144-53. PMID 26085606 DOI: 10.1212/WNL.0000000000001738  0.76
2015 Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, ... ... Trojanowski JQ, et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 6: 7247. PMID 26077951 DOI: 10.1038/ncomms8247  0.76
2015 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Green RC, Harvey D, Jack CR, Jagust W, Luthman J, Morris JC, Petersen RC, Saykin AJ, Shaw L, ... ... Trojanowski JQ, et al. 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: e1-e120. PMID 26073027 DOI: 10.1016/j.jalz.2014.11.001  0.76
2015 Wheeler JM, McMillan PJ, Hawk M, Iba M, Robinson L, Xu GJ, Dombroski BA, Jeong D, Dichter MA, Juul H, Loomis E, Raskind M, Leverenz JB, Trojanowski JQ, Lee VM, et al. High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration. Acta Neuropathologica Communications. 3: 33. PMID 26041339 DOI: 10.1186/s40478-015-0210-6  0.6
2015 Suh E, Lee EB, Neal D, Wood EM, Toledo JB, Rennert L, Irwin DJ, McMillan CT, Krock B, Elman LB, McCluskey LF, Grossman M, Xie SX, Trojanowski JQ, Van Deerlin VM. Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration. Acta Neuropathologica. PMID 26022924 DOI: 10.1007/s00401-015-1445-9  0.76
2015 Risacher SL, Kim S, Nho K, Foroud T, Shen L, Petersen RC, Jack CR, Beckett LA, Aisen PS, Koeppe RA, Jagust WJ, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ, et al. APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 25960448 DOI: 10.1016/j.jalz.2015.03.003  0.52
2015 Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, ... ... Trojanowski JQ, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. Plos One. 10: e0125614. PMID 25933020 DOI: 10.1371/journal.pone.0125614  0.76
2015 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 129: 929. PMID 25931052 DOI: 10.1007/s00401-015-1428-x  0.8
2015 Mitsui J, Matsukawa T, Sasaki H, Yabe I, Matsushima M, Dürr A, Brice A, Takashima H, Kikuchi A, Aoki M, Ishiura H, Yasuda T, Date H, Ahsan B, Iwata A, ... ... Trojanowski JQ, et al. Variants associated with Gaucher disease in multiple system atrophy. Annals of Clinical and Translational Neurology. 2: 417-26. PMID 25909086 DOI: 10.1002/acn3.185  0.6
2015 Goossens J, Vanmechelen E, Trojanowski JQ, Lee VM, Van Broeckhoven C, van der Zee J, Engelborghs S. TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies. Acta Neuropathologica Communications. 3: 15. PMID 25853864 DOI: 10.1186/s40478-015-0195-1  0.6
2015 Haris M, Yadav SK, Rizwan A, Singh A, Cai K, Kaura D, Wang E, Davatzikos C, Trojanowski JQ, Melhem ER, Marincola FM, Borthakur A. T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease. Neuroimage. Clinical. 7: 598-604. PMID 25844314 DOI: 10.1016/j.nicl.2015.02.016  0.76
2015 Toledo JB, Bjerke M, Da X, Landau SM, Foster NL, Jagust W, Jack C, Weiner M, Davatzikos C, Shaw LM, Trojanowski JQ. Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease. Jama Neurology. 72: 571-81. PMID 25822737 DOI: 10.1001/jamaneurol.2014.4829  0.76
2015 Cornec AS, James MJ, Kovalevich J, Trojanowski JQ, Lee VM, Smith AB, Ballatore C, Brunden KR. Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine. Bioorganic & Medicinal Chemistry Letters. PMID 25819095 DOI: 10.1016/j.bmcl.2015.03.002  0.76
2015 Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, ... ... Trojanowski JQ, et al. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathologica. 129: 757-62. PMID 25778618 DOI: 10.1007/s00401-015-1407-2  0.76
2015 Porta S, Kwong LK, Trojanowski JQ, Lee VM. Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases. Journal of Neuropathology and Experimental Neurology. 74: 380-7. PMID 25756586 DOI: 10.1097/NEN.0000000000000182  0.76
2015 Hu WT, Watts KD, Shaw LM, Howell JC, Trojanowski JQ, Basra S, Glass JD, Lah JJ, Levey AI. CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease? Annals of Clinical and Translational Neurology. 2: 131-9. PMID 25750918 DOI: 10.1002/acn3.160  0.56
2015 Weintraub D, Simuni T, Caspell-Garcia C, Coffey C, Lasch S, Siderowf A, Aarsland D, Barone P, Burn D, Chahine LM, Eberling J, Espay AJ, Foster ED, Leverenz JB, Litvan I, et al. Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 919-27. PMID 25737166 DOI: 10.1002/mds.26170  0.76
2015 Perry D, Sperling R, Katz R, Berry D, Dilts D, Hanna D, Salloway S, Trojanowski JQ, Bountra C, Krams M, Luthman J, Potkin S, Gribkoff V, Temple R, Wang Y, et al. Building a roadmap for developing combination therapies for Alzheimer's disease. Expert Review of Neurotherapeutics. 15: 327-33. PMID 25708309 DOI: 10.1586/14737175.2015.996551  0.76
2015 Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, ... ... Trojanowski JQ, et al. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science (New York, N.Y.). 347: 1436-41. PMID 25700176 DOI: 10.1126/science.aaa3650  0.8
2015 Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, et al. PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. Neurology. 84: 972-80. PMID 25663231 DOI: 10.1212/WNL.0000000000001332  0.76
2015 Yu L, De Jager PL, Yang J, Trojanowski JQ, Bennett DA, Schneider JA. The TMEM106B locus and TDP-43 pathology in older persons without FTLD. Neurology. 84: 927-34. PMID 25653292 DOI: 10.1212/WNL.0000000000001313  0.76
2015 Srivatsal S, Cholerton B, Leverenz JB, Wszolek ZK, Uitti RJ, Dickson DW, Weintraub D, Trojanowski JQ, Van Deerlin VM, Quinn JF, Chung KA, Peterson AL, Factor SA, Wood-Siverio C, Goldman JG, et al. Cognitive profile of LRRK2-related Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 728-33. PMID 25650144 DOI: 10.1002/mds.26161  0.76
2015 Apostolova LG, Hwang KS, Avila D, Elashoff D, Kohannim O, Teng E, Sokolow S, Jack CR, Jagust WJ, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM. Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures. Neurology. 84: 729-37. PMID 25609767 DOI: 10.1212/WNL.0000000000001231  0.76
2015 Brettschneider J, Del Tredici K, Lee VM, Trojanowski JQ. Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nature Reviews. Neuroscience. 16: 109-20. PMID 25588378 DOI: 10.1038/nrn3887  0.76
2015 Cohen TJ, Hwang AW, Restrepo CR, Yuan CX, Trojanowski JQ, Lee VM. An acetylation switch controls TDP-43 function and aggregation propensity. Nature Communications. 6: 5845. PMID 25556531 DOI: 10.1038/ncomms6845  0.68
2015 Irwin DJ, Cairns NJ, Grossman M, McMillan CT, Lee EB, Van Deerlin VM, Lee VM, Trojanowski JQ. Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine. Acta Neuropathologica. 129: 469-91. PMID 25549971 DOI: 10.1007/s00401-014-1380-1  0.76
2015 Teng E, Chow N, Hwang KS, Thompson PM, Gylys KH, Cole GM, Jack CR, Shaw LM, Trojanowski JQ, Soares HD, Weiner MW, Apostolova LG. Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dementia and Geriatric Cognitive Disorders. 39: 154-66. PMID 25547651 DOI: 10.1159/000368982  0.76
2015 Mattsson N, Insel PS, Donohue M, Landau S, Jagust WJ, Shaw LM, Trojanowski JQ, Zetterberg H, Blennow K, Weiner MW. Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease. Brain : a Journal of Neurology. 138: 772-83. PMID 25541191 DOI: 10.1093/brain/awu367  0.76
2015 Boluda S, Iba M, Zhang B, Raible KM, Lee VM, Trojanowski JQ. Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta Neuropathologica. 129: 221-37. PMID 25534024 DOI: 10.1007/s00401-014-1373-0  0.76
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Trojanowski JQ, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/jamaneurol.2014.2157  0.76
2015 Kalia LV, Lang AE, Hazrati LN, Fujioka S, Wszolek ZK, Dickson DW, Ross OA, Van Deerlin VM, Trojanowski JQ, Hurtig HI, Alcalay RN, Marder KS, Clark LN, Gaig C, Tolosa E, et al. Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease. Jama Neurology. 72: 100-5. PMID 25401511 DOI: 10.1001/jamaneurol.2014.2704  0.76
2015 Shinagawa S, Naasan G, Karydas AM, Coppola G, Pribadi M, Seeley WW, Trojanowski JQ, Miller BL, Grinberg LT. Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions. Journal of Geriatric Psychiatry and Neurology. 28: 99-107. PMID 25342578 DOI: 10.1177/0891988714554710  0.76
2015 O'Bryant SE, Gupta V, Henriksen K, Edwards M, Jeromin A, Lista S, Bazenet C, Soares H, Lovestone S, Hampel H, Montine T, Blennow K, Foroud T, Carrillo M, Graff-Radford N, ... ... Trojanowski JQ, et al. Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 549-60. PMID 25282381 DOI: 10.1016/j.jalz.2014.08.099  0.76
2015 Swanson CR, Li K, Unger TL, Gallagher MD, Van Deerlin VM, Agarwal P, Leverenz J, Roberts J, Samii A, Gross RG, Hurtig H, Rick J, Weintraub D, Trojanowski JQ, Zabetian C, et al. Lower plasma apolipoprotein A1 levels are found in Parkinson's disease and associate with apolipoprotein A1 genotype. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 805-12. PMID 25227208 DOI: 10.1002/mds.26022  0.76
2015 Peeraer E, Bottelbergs A, Van Kolen K, Stancu IC, Vasconcelos B, Mahieu M, Duytschaever H, Ver Donck L, Torremans A, Sluydts E, Van Acker N, Kemp JA, Mercken M, Brunden KR, Trojanowski JQ, et al. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of Disease. 73: 83-95. PMID 25220759 DOI: 10.1016/j.nbd.2014.08.032  0.68
2015 Nosheny RL, Insel PS, Truran D, Schuff N, Jack CR, Aisen PS, Shaw LM, Trojanowski JQ, Weiner MW. Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment. Neurobiology of Aging. 36: 273-82. PMID 25175807 DOI: 10.1016/j.neurobiolaging.2014.07.036  0.76
2015 Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, ... ... Trojanowski JQ, et al. At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 70-98. PMID 25022540 DOI: 10.1016/j.jalz.2014.04.514  0.76
2015 Toledo JB, Zetterberg H, Van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, ... ... Trojanowski JQ, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects Brain. 138: 2701-2715. DOI: 10.1093/brain/awv199  0.76
2015 Fitts W, Weintraub D, Massimo L, Chahine L, Chen-Plotkin A, Duda JE, Hurtig HI, Rick J, Trojanowski JQ, Dahodwala N. Caregiver report of apathy predicts dementia in Parkinson's disease Parkinsonism and Related Disorders. DOI: 10.1016/j.parkreldis.2015.06.009  0.76
2015 Torralva T, Sposato LA, Riccio PM, Gleichgerrcht E, Roca M, Toledo JB, Trojanowski JQ, Kukull WA, Manes F, Hachinski V. Role of brain infarcts in behavioral variant frontotemporal dementia. Clinicopathological characterization in the National Alzheimer's Coordinating Center database Neurobiology of Aging. DOI: 10.1016/j.neurobiolaging.2015.06.026  0.76
2015 Risacher SL, Kim S, Nho K, Foroud T, Shen L, Petersen RC, Jack CR, Beckett LA, Aisen PS, Koeppe RA, Jagust WJ, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ. APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern Alzheimer's and Dementia. DOI: 10.1016/j.jalz.2015.03.003  0.76
2015 Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, ... ... Trojanowski JQ, et al. Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 1: 339-348. DOI: 10.1016/j.dadm.2015.06.008  0.76
2015 Brennan L, Siderowf A, Rubright JD, Rick J, Dahodwala N, Duda JE, Hurtig H, Stern M, Xie SX, Rennert L, Karlawish J, Shea JA, Trojanowski JQ, Weintraub D. Development and initial testing of the Penn Parkinson's Daily Activities Questionnaire Movement Disorders. DOI: 10.1002/mds.26339  0.76
2014 Kang JH, Ryoo NY, Shin DW, Trojanowski JQ, Shaw LM. Role of cerebrospinal fluid biomarkers in clinical trials for Alzheimer's disease modifying therapies. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology. 18: 447-56. PMID 25598657 DOI: 10.4196/kjpp.2014.18.6.447  0.76
2014 Insel PS, Mattsson N, Donohue MC, Mackin RS, Aisen PS, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW. The transitional association between β-amyloid pathology and regional brain atrophy. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 25499535 DOI: 10.1016/j.jalz.2014.11.002  0.76
2014 Toledo JB, Korff A, Shaw LM, Trojanowski JQ, Zhang J. Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment. Alzheimer's Research & Therapy. 6: 36. PMID 25478014 DOI: 10.1186/alzrt266  0.76
2014 Ramanan VK, Nho K, Shen L, Risacher SL, Kim S, McDonald BC, Farlow MR, Foroud TM, Gao S, Soininen H, K?oszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, ... ... Trojanowski JQ, et al. FASTKD2 is associated with memory and hippocampal structure in older adults. Molecular Psychiatry. PMID 25385369 DOI: 10.1038/mp.2014.142  0.76
2014 van Steenoven I, Aarsland D, Hurtig H, Chen-Plotkin A, Duda JE, Rick J, Chahine LM, Dahodwala N, Trojanowski JQ, Roalf DR, Moberg PJ, Weintraub D. Conversion between mini-mental state examination, montreal cognitive assessment, and dementia rating scale-2 scores in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1809-15. PMID 25381961 DOI: 10.1002/mds.26062  0.76
2014 Mattsson N, Insel PS, Landau S, Jagust W, Donohue M, Shaw LM, Trojanowski JQ, Zetterberg H, Blennow K, Weiner M. Diagnostic accuracy of CSF Ab42 and florbetapir PET for Alzheimer's disease. Annals of Clinical and Translational Neurology. 1: 534-43. PMID 25356425 DOI: 10.1002/acn3.81  0.52
2014 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathologica. 128: 755-66. PMID 25348064 DOI: 10.1007/s00401-014-1349-0  0.76
2014 Wang X, Liu L, Huang L, Herbst-Robinson K, Cornec AS, James MJ, Sugiyama S, Bassetto M, Brancale A, Trojanowski JQ, Lee VM, Smith AB, Brunden KR, Ballatore C. Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. Acs Medicinal Chemistry Letters. 5: 1015-20. PMID 25221659 DOI: 10.1021/ml5002085  0.76
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Trojanowski JQ, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/jamaneurol.2014.1491  0.76
2014 Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Kamboh MI, ... ... Trojanowski JQ, et al. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. Plos Genetics. 10: e1004606. PMID 25188341 DOI: 10.1371/journal.pgen.1004606  0.76
2014 Mata IF, Leverenz JB, Weintraub D, Trojanowski JQ, Hurtig HI, Van Deerlin VM, Ritz B, Rausch R, Rhodes SL, Factor SA, Wood-Siverio C, Quinn JF, Chung KA, Peterson AL, Espay AJ, et al. APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease. Jama Neurology. 71: 1405-12. PMID 25178429 DOI: 10.1001/jamaneurol.2014.1455  0.76
2014 Ballatore C, Gay B, Huang L, Robinson KH, James MJ, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group. Bioorganic & Medicinal Chemistry Letters. 24: 4171-5. PMID 25127105 DOI: 10.1016/j.bmcl.2014.07.047  0.76
2014 Yarchoan M, Toledo JB, Lee EB, Arvanitakis Z, Kazi H, Han LY, Louneva N, Lee VM, Kim SF, Trojanowski JQ, Arnold SE. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathologica. 128: 679-89. PMID 25107476 DOI: 10.1007/s00401-014-1328-5  0.76
2014 Burdick DJ, Cholerton B, Watson GS, Siderowf A, Trojanowski JQ, Weintraub D, Ritz B, Rhodes SL, Rausch R, Factor SA, Wood-Siverio C, Quinn JF, Chung KA, Srivatsal S, Edwards KL, et al. People with Parkinson's disease and normal MMSE score have a broad range of cognitive performance. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1258-64. PMID 25073717 DOI: 10.1002/mds.25924  0.76
2014 Paterson RW, Bartlett JW, Blennow K, Fox NC, Shaw LM, Trojanowski JQ, Zetterberg H, Schott JM. Cerebrospinal fluid markers including trefoil factor 3 are associated with neurodegeneration in amyloid-positive individuals. Translational Psychiatry. 4: e419. PMID 25072324 DOI: 10.1038/tp.2014.58  0.76
2014 Durazzo TC, Mattsson N, Weiner MW, Korecka M, Trojanowski JQ, Shaw LM. History of cigarette smoking in cognitively-normal elders is associated with elevated cerebrospinal fluid biomarkers of oxidative stress. Drug and Alcohol Dependence. 142: 262-8. PMID 25037769 DOI: 10.1016/j.drugalcdep.2014.06.030  0.76
2014 Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain : a Journal of Neurology. 137: 2578-87. PMID 25012223 DOI: 10.1093/brain/awu190  0.76
2014 Irwin DJ, McMillan CT, Suh E, Powers J, Rascovsky K, Wood EM, Toledo JB, Arnold SE, Lee VM, Van Deerlin VM, Trojanowski JQ, Grossman M. Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia. Neurology. 83: 502-9. PMID 24994843 DOI: 10.1212/WNL.0000000000000668  0.76
2014 Lou K, Yao Y, Hoye AT, James MJ, Cornec AS, Hyde E, Gay B, Lee VM, Trojanowski JQ, Smith AB, Brunden KR, Ballatore C. Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies. Journal of Medicinal Chemistry. 57: 6116-27. PMID 24992153 DOI: 10.1021/jm5005623  0.76
2014 Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, ... ... Trojanowski JQ, et al. Frontotemporal dementia and its subtypes: a genome-wide association study. The Lancet. Neurology. 13: 686-99. PMID 24943344 DOI: 10.1016/S1474-4422(14)70065-1  0.56
2014 Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM. Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration. Cell Reports. 7: 2054-65. PMID 24931606 DOI: 10.1016/j.celrep.2014.05.033  0.76
2014 Weiner MW, Veitch DP, Hayes J, Neylan T, Grafman J, Aisen PS, Petersen RC, Jack C, Jagust W, Trojanowski JQ, Shaw LM, Saykin AJ, Green RC, Harvey D, Toga AW, et al. Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S226-35. PMID 24924673 DOI: 10.1016/j.jalz.2014.04.005  0.76
2014 Boluda S, Toledo JB, Irwin DJ, Raible KM, Byrne MD, Lee EB, Lee VM, Trojanowski JQ. A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis. Acta Neuropathologica. 128: 543-50. PMID 24916271 DOI: 10.1007/s00401-014-1308-9  0.76
2014 Brettschneider J, Arai K, Del Tredici K, Toledo JB, Robinson JL, Lee EB, Kuwabara S, Shibuya K, Irwin DJ, Fang L, Van Deerlin VM, Elman L, McCluskey L, Ludolph AC, Lee VM, ... ... Trojanowski JQ, et al. TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathologica. 128: 423-37. PMID 24916269 DOI: 10.1007/s00401-014-1299-6  0.76
2014 McCluskey LF, Geser F, Elman LB, Van Deerlin VM, Robinson JL, Lee VM, Trojanowski JQ. Atypical Alzheimer's disease in an elderly United States resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 15: 466-72. PMID 24809433 DOI: 10.3109/21678421.2014.903973  0.76
2014 Walker AK, Daniels CM, Goldman JE, Trojanowski JQ, Lee VM, Messing A. Astrocytic TDP-43 pathology in Alexander disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6448-58. PMID 24806671 DOI: 10.1523/JNEUROSCI.0248-14.2014  0.76
2014 Mattsson N, Insel PS, Nosheny R, Tosun D, Trojanowski JQ, Shaw LM, Jack CR, Donohue MC, Weiner MW. Emerging β-amyloid pathology and accelerated cortical atrophy. Jama Neurology. 71: 725-34. PMID 24781145 DOI: 10.1001/jamaneurol.2014.446  0.76
2014 Leinonen V, Rinne JO, Wong DF, Wolk DA, Trojanowski JQ, Sherwin PF, Smith A, Heurling K, Su M, Grachev ID. Diagnostic effectiveness of quantitative [¹⁸F]flutemetamol PET imaging for detection of fibrillar amyloid β using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus. Acta Neuropathologica Communications. 2: 46. PMID 24755237 DOI: 10.1186/2051-5960-2-46  0.76
2014 Bit-Ivan EN, Suh E, Shim HS, Weintraub S, Hyman BT, Arnold SE, McCarty-Wood E, Van Deerlin VM, Schneider JA, Trojanowski JQ, Frosch MP, Baker MC, Rademakers R, Mesulam M, Bigio EH. A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases. Journal of Neuropathology and Experimental Neurology. 73: 467-73. PMID 24709683 DOI: 10.1097/NEN.0000000000000070  0.76
2014 Kwong LK, Irwin DJ, Walker AK, Xu Y, Riddle DM, Trojanowski JQ, Lee VM. Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins. Acta Neuropathologica Communications. 2: 33. PMID 24690345 DOI: 10.1186/2051-5960-2-33  0.76
2014 McMillan CT, Avants BB, Cook P, Ungar L, Trojanowski JQ, Grossman M. The power of neuroimaging biomarkers for screening frontotemporal dementia. Human Brain Mapping. 35: 4827-40. PMID 24687814 DOI: 10.1002/hbm.22515  0.76
2014 Apostolova LG, Hwang KS, Kohannim O, Avila D, Elashoff D, Jack CR, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM. ApoE4 effects on automated diagnostic classifiers for mild cognitive impairment and Alzheimer's disease. Neuroimage. Clinical. 4: 461-72. PMID 24634832 DOI: 10.1016/j.nicl.2013.12.012  0.76
2014 Korecka M, Waligorska T, Figurski M, Toledo JB, Arnold SE, Grossman M, Trojanowski JQ, Shaw LM. Qualification of a surrogate matrix-based absolute quantification method for amyloid-β₄₂ in human cerebrospinal fluid using 2D UPLC-tandem mass spectrometry. Journal of Alzheimer's Disease : Jad. 41: 441-51. PMID 24625802 DOI: 10.3233/JAD-132489  0.8
2014 Toledo JB, Weiner MW, Wolk DA, Da X, Chen K, Arnold SE, Jagust W, Jack C, Reiman EM, Davatzikos C, Shaw LM, Trojanowski JQ. Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition. Acta Neuropathologica Communications. 2: 26. PMID 24602322 DOI: 10.1186/2051-5960-2-26  0.76
2014 Nuytemans K, Inchausti V, Beecham GW, Wang L, Dickson DW, Trojanowski JQ, Lee VM, Mash DC, Frosch MP, Foroud TM, Honig LS, Montine TJ, Dawson TM, Martin ER, Scott WK, et al. Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 827-30. PMID 24573903 DOI: 10.1002/mds.25838  0.76
2014 Grossman M, Elman L, McCluskey L, McMillan CT, Boller A, Powers J, Rascovsky K, Hu W, Shaw L, Irwin DJ, Lee VM, Trojanowski JQ. Phosphorylated tau as a candidate biomarker for amyotrophic lateral sclerosis. Jama Neurology. 71: 442-8. PMID 24492862 DOI: 10.1001/jamaneurol.2013.6064  0.76
2014 Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, ... ... Trojanowski JQ, et al. TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathologica. 127: 407-18. PMID 24442578 DOI: 10.1007/s00401-013-1239-x  0.76
2014 Brunden KR, Trojanowski JQ, Smith AB, Lee VM, Ballatore C. Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease. Bioorganic & Medicinal Chemistry. 22: 5040-9. PMID 24433963 DOI: 10.1016/j.bmc.2013.12.046  0.68
2014 Sondheimer N, Zollo O, Van Deerlin V, Trojanowski JQ. Analysis of cerebrospinal fluid mitochondrial DNA levels in Alzheimer disease. Annals of Neurology. 75: 458-60. PMID 24424574 DOI: 10.1002/ana.24107  0.76
2014 Jedrziewski MK, Ewbank DC, Wang H, Trojanowski JQ. The Impact of Exercise, Cognitive Activities, and Socialization on Cognitive Function: Results From the National Long-Term Care Survey. American Journal of Alzheimer's Disease and Other Dementias. 29: 372-378. PMID 24408752 DOI: 10.1177/1533317513518646  0.76
2014 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 127: 423-39. PMID 24407427 DOI: 10.1007/s00401-013-1238-y  0.76
2014 Ballatore C, Smith AB, Lee VM, Trojanowski JQ, Brunden KR. Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497. Expert Opinion On Therapeutic Patents. 24: 355-60. PMID 24387030 DOI: 10.1517/13543776.2014.871526  0.76
2014 Toledo JB, Da X, Weiner MW, Wolk DA, Xie SX, Arnold SE, Davatzikos C, Shaw LM, Trojanowski JQ. CSF Apo-E levels associate with cognitive decline and MRI changes. Acta Neuropathologica. 127: 621-32. PMID 24385135 DOI: 10.1007/s00401-013-1236-0  0.76
2014 McMillan CT, Toledo JB, Avants BB, Cook PA, Wood EM, Suh E, Irwin DJ, Powers J, Olm C, Elman L, McCluskey L, Schellenberg GD, Lee VM, Trojanowski JQ, Van Deerlin VM, et al. Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration. Neurobiology of Aging. 35: 1473-82. PMID 24373676 DOI: 10.1016/j.neurobiolaging.2013.11.029  0.76
2014 Da X, Toledo JB, Zee J, Wolk DA, Xie SX, Ou Y, Shacklett A, Parmpi P, Shaw L, Trojanowski JQ, Davatzikos C. Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers. Neuroimage. Clinical. 4: 164-73. PMID 24371799 DOI: 10.1016/j.nicl.2013.11.010  0.76
2014 Johnston JM, Hu WT, Fardo DW, Greco SJ, Perry G, Montine TJ, Trojanowski JQ, Shaw LM, Ashford JW, Tezapsidis N. Low plasma leptin in cognitively impaired ADNI subjects: gender differences and diagnostic and therapeutic potential. Current Alzheimer Research. 11: 165-74. PMID 24359504 DOI: 10.2174/1567205010666131212114156  0.76
2014 Sánchez-Juan P, Ghosh PM, Hagen J, Gesierich B, Henry M, Grinberg LT, O'Neil JP, Janabi M, Huang EJ, Trojanowski JQ, Vinters HV, Gorno-Tempini M, Seeley WW, Boxer AL, Rosen HJ, et al. Practical utility of amyloid and FDG-PET in an academic dementia center. Neurology. 82: 230-8. PMID 24353340 DOI: 10.1212/WNL.0000000000000032  0.76
2014 Caso F, Mandelli ML, Henry M, Gesierich B, Bettcher BM, Ogar J, Filippi M, Comi G, Magnani G, Sidhu M, Trojanowski JQ, Huang EJ, Grinberg LT, Miller BL, Dronkers N, et al. In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology. Neurology. 82: 239-47. PMID 24353332 DOI: 10.1212/WNL.0000000000000031  0.76
2014 Kim HJ, Raphael AR, LaDow ES, McGurk L, Weber RA, Trojanowski JQ, Lee VM, Finkbeiner S, Gitler AD, Bonini NM. Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nature Genetics. 46: 152-60. PMID 24336168 DOI: 10.1038/ng.2853  0.76
2014 Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack CR, Tosun D, Weiner M. Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults. Neurobiology of Aging. 35: 614-22. PMID 24094581 DOI: 10.1016/j.neurobiolaging.2013.08.027  0.76
2014 Toledo JB, Van Deerlin VM, Lee EB, Suh E, Baek Y, Robinson JL, Xie SX, McBride J, Wood EM, Schuck T, Irwin DJ, Gross RG, Hurtig H, McCluskey L, Elman L, ... ... Trojanowski JQ, et al. A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 477-84.e1. PMID 23978324 DOI: 10.1016/j.jalz.2013.06.003  0.76
2014 Henriksen K, O'Bryant SE, Hampel H, Trojanowski JQ, Montine TJ, Jeromin A, Blennow K, Lönneborg A, Wyss-Coray T, Soares H, Bazenet C, Sjögren M, Hu W, Lovestone S, Karsdal MA, et al. The future of blood-based biomarkers for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 115-31. PMID 23850333 DOI: 10.1016/j.jalz.2013.01.013  0.76
2014 Swaminathan S, Risacher SL, Yoder KK, West JD, Shen L, Kim S, Inlow M, Foroud T, Jagust WJ, Koeppe RA, Mathis CA, Shaw LM, Trojanowski JQ, Soares H, Aisen PS, et al. Association of plasma and cortical amyloid beta is modulated by APOE ε4 status. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: e9-e18. PMID 23541187 DOI: 10.1016/j.jalz.2013.01.007  0.76
2014 Roy S, Irwin DJ, Lee VMY, Trojanowski JQ. Axonal Transport and Neurodegenerative Diseases Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.04517-7  0.68
2014 Kang JH, Korecka M, Toledo JB, Trojanowski JQ, Shaw LM. Clinical utility and analytical challenges in measurement of cerebrospinal fluid amyloid-β1-42 and τ proteins as Alzheimer disease biomarkers | Utilità clinica e problematiche analitiche nelle misure di amiloide-β1-42e proteine tau nel liquido cefalorachidiano come marcatori della malattia di Alzheimer Biochimica Clinica. 38: 255-267.  0.76
2013 Brunden KR, Gardner NM, James MJ, Yao Y, Trojanowski JQ, Lee VM, Paterson I, Ballatore C, Smith AB. MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. Acs Medicinal Chemistry Letters. 4: 886-9. PMID 24900764 DOI: 10.1021/ml400233e  0.76
2013 Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VM, Trojanowski JQ, Chen-Plotkin AS. Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain. Acta Neuropathologica Communications. 1: 36. PMID 24252750 DOI: 10.1186/2051-5960-1-36  0.76
2013 Stutzbach LD, Xie SX, Naj AC, Albin R, Gilman S, Lee VM, Trojanowski JQ, Devlin B, Schellenberg GD. The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. Acta Neuropathologica Communications. 1: 31. PMID 24252572 DOI: 10.1186/2051-5960-1-31  0.68
2013 Toledo JB, Cairns NJ, Da X, Chen K, Carter D, Fleisher A, Householder E, Ayutyanont N, Roontiva A, Bauer RJ, Eisen P, Shaw LM, Davatzikos C, Weiner MW, Reiman EM, ... ... Trojanowski JQ, et al. Clinical and multimodal biomarker correlates of ADNI neuropathological findings. Acta Neuropathologica Communications. 1: 65. PMID 24252435 DOI: 10.1186/2051-5960-1-65  0.76
2013 Motsinger-Reif AA, Zhu H, Kling MA, Matson W, Sharma S, Fiehn O, Reif DM, Appleby DH, Doraiswamy PM, Trojanowski JQ, Kaddurah-Daouk R, Arnold SE. Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging. Acta Neuropathologica Communications. 1: 28. PMID 24252434 DOI: 10.1186/2051-5960-1-28  0.76
2013 Braak H, Brettschneider J, Ludolph AC, Lee VM, Trojanowski JQ, Del Tredici K. Amyotrophic lateral sclerosis--a model of corticofugal axonal spread. Nature Reviews. Neurology. 9: 708-14. PMID 24217521 DOI: 10.1038/nrneurol.2013.221  0.76
2013 Hu WT, Watts K, Grossman M, Glass J, Lah JJ, Hales C, Shelnutt M, Van Deerlin V, Trojanowski JQ, Levey AI. Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP. Neurology. 81: 1945-52. PMID 24174584 DOI: 10.1212/01.wnl.0000436625.63650.27  0.76
2013 Hu WT, Shaw LM, Trojanowski JQ. Alzheimer's disease biomarkers: walk with deliberate haste, don't run blithely on? Acta Neuropathologica. 126: 625-9. PMID 24154963 DOI: 10.1007/s00401-013-1197-3  0.76
2013 Wilson RS, Yu L, Trojanowski JQ, Chen EY, Boyle PA, Bennett DA, Schneider JA. TDP-43 pathology, cognitive decline, and dementia in old age. Jama Neurology. 70: 1418-24. PMID 24080705 DOI: 10.1001/jamaneurol.2013.3961  0.76
2013 Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 79: 1094-108. PMID 24050400 DOI: 10.1016/j.neuron.2013.07.037  0.32
2013 Lee EB, Russ J, Jung H, Elman LB, Chahine LM, Kremens D, Miller BL, Branch Coslett H, Trojanowski JQ, Van Deerlin VM, McCluskey LF. Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U. Acta Neuropathologica Communications. 1: 1-11. PMID 24027631 DOI: 10.1186/2051-5960-1-9  0.8
2013 Kang JH, Irwin DJ, Chen-Plotkin AS, Siderowf A, Caspell C, Coffey CS, Waligórska T, Taylor P, Pan S, Frasier M, Marek K, Kieburtz K, Jennings D, Simuni T, Tanner CM, ... ... Trojanowski JQ, et al. Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease. Jama Neurology. 70: 1277-87. PMID 23979011 DOI: 10.1001/jamaneurol.2013.3861  0.76
2013 Yarchoan M, Louneva N, Xie SX, Swenson FJ, Hu W, Soares H, Trojanowski JQ, Lee VM, Kling MA, Shaw LM, Chen-Plotkin A, Wolk DA, Arnold SE. Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease. Journal of the Neurological Sciences. 333: 9-12. PMID 23978419 DOI: 10.1016/j.jns.2013.05.028  0.76
2013 Mattsson N, Insel P, Nosheny R, Zetterberg H, Trojanowski JQ, Shaw LM, Tosun D, Weiner M. CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy elders. Translational Psychiatry. 3: e293. PMID 23962923 DOI: 10.1038/tp.2013.69  0.76
2013 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Liu E, Morris JC, Petersen RC, Saykin AJ, Schmidt ME, Shaw L, ... ... Trojanowski JQ, et al. The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: e111-94. PMID 23932184 DOI: 10.1016/j.jalz.2013.05.1769  0.76
2013 Irwin DJ, Lee VM, Trojanowski JQ. Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies. Nature Reviews. Neuroscience. 14: 626-36. PMID 23900411 DOI: 10.1038/nrn3549  0.76
2013 Kim S, Swaminathan S, Inlow M, Risacher SL, Nho K, Shen L, Foroud TM, Petersen RC, Aisen PS, Soares H, Toledo JB, Shaw LM, Trojanowski JQ, Weiner MW, McDonald BC, et al. Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel. Plos One. 8: e70269. PMID 23894628 DOI: 10.1371/journal.pone.0070269  0.76
2013 Irwin DJ, Cohen TJ, Grossman M, Arnold SE, McCarty-Wood E, Van Deerlin VM, Lee VM, Trojanowski JQ. Acetylated tau neuropathology in sporadic and hereditary tauopathies. The American Journal of Pathology. 183: 344-51. PMID 23885714 DOI: 10.1016/j.ajpath.2013.04.025  0.76
2013 Arnold SE, Toledo JB, Appleby DH, Xie SX, Wang LS, Baek Y, Wolk DA, Lee EB, Miller BL, Lee VM, Trojanowski JQ. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. The Journal of Comparative Neurology. 521: 4339-55. PMID 23881776 DOI: 10.1002/cne.23430  0.76
2013 Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M, Monsell SE, Kukull WA, Trojanowski JQ. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain : a Journal of Neurology. 136: 2697-706. PMID 23842566 DOI: 10.1093/brain/awt188  0.76
2013 Irwin DJ, Trojanowski JQ. Many roads to Parkinson's disease neurodegeneration: head trauma-a road more traveled than we know? Movement Disorders : Official Journal of the Movement Disorder Society. 28: 1167-70. PMID 23836759 DOI: 10.1002/mds.25551  0.76
2013 Guo JL, Covell DJ, Daniels JP, Iba M, Stieber A, Zhang B, Riddle DM, Kwong LK, Xu Y, Trojanowski JQ, Lee VM. Distinct α-synuclein strains differentially promote tau inclusions in neurons. Cell. 154: 103-17. PMID 23827677 DOI: 10.1016/j.cell.2013.05.057  0.76
2013 Toledo JB, Xie SX, Trojanowski JQ, Shaw LM. Longitudinal change in CSF Tau and Aβ biomarkers for up to 48 months in ADNI. Acta Neuropathologica. 126: 659-70. PMID 23812320 DOI: 10.1007/s00401-013-1151-4  0.76
2013 Toledo JB, Korff A, Shaw LM, Trojanowski JQ, Zhang J. CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease. Acta Neuropathologica. 126: 683-97. PMID 23812319 DOI: 10.1007/s00401-013-1148-z  0.76
2013 Mitsui J, Matsukawa T, Ishiura H, Fukuda Y, Ichikawa Y, Date H, Ahsan B, Nakahara Y, Momose Y, Takahashi Y, Iwata A, Goto J, Yamamoto Y, Komata M, Shirahige K, ... ... Trojanowski JQ, et al. Mutations in COQ2 in familial and sporadic multiple-system atrophy the multiple-system atrophy research collaboration New England Journal of Medicine. 369: 233-244. PMID 23758206 DOI: 10.1056/NEJMoa1212115  0.76
2013 Chahine LM, Qiang J, Ashbridge E, Minger J, Yearout D, Horn S, Colcher A, Hurtig HI, Lee VM, Van Deerlin VM, Leverenz JB, Siderowf AD, Trojanowski JQ, Zabetian CP, Chen-Plotkin A. Clinical and biochemical differences in patients having Parkinson disease with vs without GBA mutations. Jama Neurology. 70: 852-8. PMID 23699752 DOI: 10.1001/jamaneurol.2013.1274  0.76
2013 Brettschneider J, Del Tredici K, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, ... ... Trojanowski JQ, et al. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Annals of Neurology. 74: 20-38. PMID 23686809 DOI: 10.1002/ana.23937  0.76
2013 Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, et al. Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 5-18. PMID 23678876 DOI: 10.3109/21678421.2013.778548  0.76
2013 Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, ... ... Trojanowski JQ, et al. CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 251-61. PMID 23622690 DOI: 10.1016/j.jalz.2013.01.010  0.76
2013 Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF, Morris CM, Theuns J, Crosiers D, Cras P, Engelborghs S, De Deyn PP, Van Broeckhoven C, Mann DM, Snowden J, ... ... Trojanowski JQ, et al. A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. Jama Neurology. 70: 727-35. PMID 23588557 DOI: 10.1001/jamaneurol.2013.1925  0.76
2013 Kaddurah-Daouk R, Zhu H, Sharma S, Bogdanov M, Rozen SG, Matson W, Oki NO, Motsinger-Reif AA, Churchill E, Lei Z, Appleby D, Kling MA, Trojanowski JQ, Doraiswamy PM, Arnold SE, et al. Alterations in metabolic pathways and networks in Alzheimer's disease. Translational Psychiatry. 3: e244. PMID 23571809 DOI: 10.1038/tp.2013.18  0.76
2013 Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, ... ... Trojanowski JQ, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78: 256-68. PMID 23562540 DOI: 10.1016/j.neuron.2013.02.026  0.76
2013 Risacher SL, Kim S, Shen L, Nho K, Foroud T, Green RC, Petersen RC, Jack CR, Aisen PS, Koeppe RA, Jagust WJ, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ, et al. The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI). Frontiers in Aging Neuroscience. 5: 11. PMID 23554593 DOI: 10.3389/fnagi.2013.00011  0.76
2013 Landau SM, Lu M, Joshi AD, Pontecorvo M, Mintun MA, Trojanowski JQ, Shaw LM, Jagust WJ. Comparing positron emission tomography imaging and cerebrospinal fluid measurements of β-amyloid. Annals of Neurology. 74: 826-36. PMID 23536396 DOI: 10.1002/ana.23908  0.76
2013 Kang JH, Korecka M, Toledo JB, Trojanowski JQ, Shaw LM. Clinical utility and analytical challenges in measurement of cerebrospinal fluid amyloid-β(1-42) and Ï„ proteins as Alzheimer disease biomarkers. Clinical Chemistry. 59: 903-16. PMID 23519967 DOI: 10.1373/clinchem.2013.202937  0.76
2013 McMillan CT, Irwin DJ, Avants BB, Powers J, Cook PA, Toledo JB, McCarty Wood E, Van Deerlin VM, Lee VM, Trojanowski JQ, Grossman M. White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 949-55. PMID 23475817 DOI: 10.1136/jnnp-2012-304418  0.76
2013 Berlau DJ, Corrada MM, Robinson JL, Geser F, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ. Neocortical β-amyloid area is associated with dementia and APOE in the oldest-old. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 699-705. PMID 23474043 DOI: 10.1016/j.jalz.2012.11.011  0.76
2013 Toledo JB, Shaw LM, Trojanowski JQ. Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker. Alzheimer's Research & Therapy. 5: 8. PMID 23470128 DOI: 10.1186/alzrt162  0.76
2013 Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, ... ... Trojanowski JQ, et al. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature. 495: 467-73. PMID 23455423 DOI: 10.1038/nature11922  0.76
2013 Qiang JK, Wong YC, Siderowf A, Hurtig HI, Xie SX, Lee VM, Trojanowski JQ, Yearout D, B Leverenz J, Montine TJ, Stern M, Mendick S, Jennings D, Zabetian C, Marek K, et al. Plasma apolipoprotein A1 as a biomarker for Parkinson disease. Annals of Neurology. 74: 119-27. PMID 23447138 DOI: 10.1002/ana.23872  0.76
2013 Crowe A, James MJ, Lee VM, Smith AB, Trojanowski JQ, Ballatore C, Brunden KR. Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. The Journal of Biological Chemistry. 288: 11024-37. PMID 23443659 DOI: 10.1074/jbc.M112.436006  0.76
2013 Irwin DJ, Trojanowski JQ, Grossman M. Cerebrospinal fluid biomarkers for differentiation of frontotemporal lobar degeneration from Alzheimer's disease. Frontiers in Aging Neuroscience. 5: 6. PMID 23440936 DOI: 10.3389/fnagi.2013.00006  0.76
2013 Toledo JB, Da X, Bhatt P, Wolk DA, Arnold SE, Shaw LM, Trojanowski JQ, Davatzikos C. Relationship between plasma analytes and SPARE-AD defined brain atrophy patterns in ADNI. Plos One. 8: e55531. PMID 23408997 DOI: 10.1371/journal.pone.0055531  0.76
2013 Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, et al. APOE ε4 increases risk for dementia in pure synucleinopathies. Jama Neurology. 70: 223-8. PMID 23407718 DOI: 10.1001/jamaneurol.2013.600  0.76
2013 Irwin DJ, Abrams JY, Schonberger LB, Leschek EW, Mills JL, Lee VM, Trojanowski JQ. Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone. Jama Neurology. 70: 462-8. PMID 23380910 DOI: 10.1001/jamaneurol.2013.1933  0.76
2013 Johnson VE, Stewart JE, Begbie FD, Trojanowski JQ, Smith DH, Stewart W. Inflammation and white matter degeneration persist for years after a single traumatic brain injury. Brain : a Journal of Neurology. 136: 28-42. PMID 23365092 DOI: 10.1093/brain/aws322  0.76
2013 Jack CR, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, Shaw LM, Vemuri P, Wiste HJ, Weigand SD, Lesnick TG, Pankratz VS, Donohue MC, Trojanowski JQ. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. The Lancet. Neurology. 12: 207-16. PMID 23332364 DOI: 10.1016/S1474-4422(12)70291-0  0.76
2013 Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VM. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1024-37. PMID 23325240 DOI: 10.1523/JNEUROSCI.2642-12.2013  0.76
2013 Grossman M, Powers J, Ash S, McMillan C, Burkholder L, Irwin D, Trojanowski JQ. Disruption of large-scale neural networks in non-fluent/agrammatic variant primary progressive aphasia associated with frontotemporal degeneration pathology. Brain and Language. 127: 106-20. PMID 23218686 DOI: 10.1016/j.bandl.2012.10.005  0.76
2013 Kling MA, Trojanowski JQ, Wolk DA, Lee VM, Arnold SE. Vascular disease and dementias: paradigm shifts to drive research in new directions. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 76-92. PMID 23183137 DOI: 10.1016/j.jalz.2012.02.007  0.76
2013 Watson GS, Cholerton BA, Gross RG, Weintraub D, Zabetian CP, Trojanowski JQ, Montine TJ, Siderowf A, Leverenz JB. Neuropsychologic assessment in collaborative Parkinson's disease research: a proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson's Disease Research at the University of Pennsylvania and the University of Washington. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 609-14. PMID 23164549 DOI: 10.1016/j.jalz.2012.07.006  0.76
2013 Negash S, Xie S, Davatzikos C, Clark CM, Trojanowski JQ, Shaw LM, Wolk DA, Arnold SE. Cognitive and functional resilience despite molecular evidence of Alzheimer's disease pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: e89-95. PMID 23127468 DOI: 10.1016/j.jalz.2012.01.009  0.76
2013 Robinson JL, Geser F, Stieber A, Umoh M, Kwong LK, Van Deerlin VM, Lee VM, Trojanowski JQ. TDP-43 skeins show properties of amyloid in a subset of ALS cases. Acta Neuropathologica. 125: 121-31. PMID 23124365 DOI: 10.1007/s00401-012-1055-8  0.76
2013 Irwin DJ, McMillan CT, Brettschneider J, Libon DJ, Powers J, Rascovsky K, Toledo JB, Boller A, Bekisz J, Chandrasekaran K, Wood EM, Shaw LM, Woo JH, Cook PA, Wolk DA, ... ... Trojanowski JQ, et al. Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 163-9. PMID 23117491 DOI: 10.1136/jnnp-2012-303507  0.76
2013 Arnold SE, Vega IE, Karlawish JH, Wolk DA, Nunez J, Negron M, Xie SX, Wang LS, Dubroff JG, McCarty-Wood E, Trojanowski JQ, Van Deerlin V. Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementia. Journal of Alzheimer's Disease : Jad. 33: 1089-95. PMID 23114514 DOI: 10.3233/JAD-2012-121570  0.76
2013 Yoshiyama Y, Lee VM, Trojanowski JQ. Therapeutic strategies for tau mediated neurodegeneration. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 784-95. PMID 23085937 DOI: 10.1136/jnnp-2012-303144  0.76
2013 Ramakers IH, Verhey FR, Scheltens P, Hampel H, Soininen H, Aalten P, Rikkert MO, Verbeek MM, Spiru L, Blennow K, Trojanowski JQ, Shaw LM, Visser PJ. Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment. Psychological Medicine. 43: 911-20. PMID 22954311 DOI: 10.1017/S0033291712001870  0.76
2013 Halabi C, Halabi A, Dean DL, Wang PN, Boxer AL, Trojanowski JQ, Dearmond SJ, Miller BL, Kramer JH, Seeley WW. Patterns of striatal degeneration in frontotemporal dementia. Alzheimer Disease and Associated Disorders. 27: 74-83. PMID 22367382 DOI: 10.1097/WAD.0b013e31824a7df4  0.76
2012 Yarchoan M, Xie SX, Kling MA, Toledo JB, Wolk DA, Lee EB, Van Deerlin V, Lee VM, Trojanowski JQ, Arnold SE. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain : a Journal of Neurology. 135: 3749-56. PMID 23204143 DOI: 10.1093/brain/aws271  0.76
2012 Soper JH, Sugiyama S, Herbst-Robinson K, James MJ, Wang X, Trojanowski JQ, Smith AB, Lee VM, Ballatore C, Brunden KR. Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease. Acs Chemical Neuroscience. 3: 928-40. PMID 23173073 DOI: 10.1021/cn3000795  0.76
2012 Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (New York, N.Y.). 338: 949-53. PMID 23161999 DOI: 10.1126/science.1227157  0.76
2012 Trojanowski JQ, Arnold SE, Karlawish JH, Naylor M, Brunden KR, Lee VM. A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 564-73. PMID 23102127 DOI: 10.1016/j.jalz.2011.08.005  0.76
2012 Toledo JB, Toledo E, Weiner MW, Jack CR, Jagust W, Lee VM, Shaw LM, Trojanowski JQ. Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 483-9. PMID 23102118 DOI: 10.1016/j.jalz.2011.08.008  0.76
2012 Irwin DJ, White MT, Toledo JB, Xie SX, Robinson JL, Van Deerlin V, Lee VM, Leverenz JB, Montine TJ, Duda JE, Hurtig HI, Trojanowski JQ. Neuropathologic substrates of Parkinson disease dementia. Annals of Neurology. 72: 587-98. PMID 23037886 DOI: 10.1002/ana.23659  0.76
2012 Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Kukull W, Nelson PT, Jicha GA, ... ... Trojanowski JQ, et al. GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology. Neurology. 79: 1944-50. PMID 23035075 DOI: 10.1212/WNL.0b013e3182735e9a  0.76
2012 Ballatore C, Brunden KR, Huryn DM, Trojanowski JQ, Lee VM, Smith AB. Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies. Journal of Medicinal Chemistry. 55: 8979-96. PMID 23020671 DOI: 10.1021/jm301079z  0.76
2012 Bhat R, Crowe EP, Bitto A, Moh M, Katsetos CD, Garcia FU, Johnson FB, Trojanowski JQ, Sell C, Torres C. Astrocyte senescence as a component of Alzheimer's disease. Plos One. 7: e45069. PMID 22984612 DOI: 10.1371/journal.pone.0045069  0.76
2012 Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, ... ... Trojanowski JQ, et al. Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 445-52. PMID 22959699 DOI: 10.1016/j.jalz.2012.08.001  0.76
2012 Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, et al. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. Plos One. 7: e43099. PMID 22952635 DOI: 10.1371/journal.pone.0043099  0.76
2012 Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM. TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11213-27. PMID 22895706 DOI: 10.1523/JNEUROSCI.0521-12.2012  0.76
2012 Hu WT, Holtzman DM, Fagan AM, Shaw LM, Perrin R, Arnold SE, Grossman M, Xiong C, Craig-Schapiro R, Clark CM, Pickering E, Kuhn M, Chen Y, Van Deerlin VM, McCluskey L, ... ... Trojanowski JQ, et al. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease. Neurology. 79: 897-905. PMID 22855860 DOI: 10.1212/WNL.0b013e318266fa70  0.76
2012 Arnold SE, Xie SX, Leung YY, Wang LS, Kling MA, Han X, Kim EJ, Wolk DA, Bennett DA, Chen-Plotkin A, Grossman M, Hu W, Lee VM, Mackin RS, Trojanowski JQ, et al. Plasma biomarkers of depressive symptoms in older adults. Translational Psychiatry. 2: e65. PMID 22832727 DOI: 10.1038/tp.2011.63  0.76
2012 Brunden KR, Ballatore C, Lee VM, Smith AB, Trojanowski JQ. Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. Biochemical Society Transactions. 40: 661-6. PMID 22817712 DOI: 10.1042/BST20120010  0.76
2012 Soares HD, Potter WZ, Pickering E, Kuhn M, Immermann FW, Shera DM, Ferm M, Dean RA, Simon AJ, Swenson F, Siuciak JA, Kaplow J, Thambisetty M, Zagouras P, Koroshetz WJ, ... ... Trojanowski JQ, et al. Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease. Archives of Neurology. 69: 1310-7. PMID 22801723 DOI: 10.1001/archneurol.2012.1070  0.76
2012 Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, ... ... Trojanowski JQ, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science Translational Medicine. 4: 141ra90. PMID 22764206 DOI: 10.1126/scitranslmed.3003985  0.76
2012 Figurski MJ, Waligórska T, Toledo J, Vanderstichele H, Korecka M, Lee VM, Trojanowski JQ, Shaw LM. Improved protocol for measurement of plasma β-amyloid in longitudinal evaluation of Alzheimer's Disease Neuroimaging Initiative study patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 250-60. PMID 22748936 DOI: 10.1016/j.jalz.2012.01.001  0.76
2012 Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Trojanowski JQ, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/WNL.0b013e3182605801  0.48
2012 Brettschneider J, Toledo JB, Van Deerlin VM, Elman L, McCluskey L, Lee VM, Trojanowski JQ. Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis. Plos One. 7: e39216. PMID 22720079 DOI: 10.1371/journal.pone.0039216  0.76
2012 Ballatore C, Crowe A, Piscitelli F, James M, Lou K, Rossidivito G, Yao Y, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties. Bioorganic & Medicinal Chemistry. 20: 4451-61. PMID 22717239 DOI: 10.1016/j.bmc.2012.05.027  0.76
2012 Frisoni GB, Trojanowski JQ. Primary or secondary prevention for AD: who cares? The Lancet. Neurology. 11: 661-2. PMID 22705337 DOI: 10.1016/S1474-4422(12)70143-6  0.76
2012 Hurtado DE, Molina-Porcel L, Carroll JC, Macdonald C, Aboagye AK, Trojanowski JQ, Lee VM. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7392-402. PMID 22623685 DOI: 10.1523/JNEUROSCI.0889-12.2012  0.76
2012 Wang LS, Leung YY, Chang SK, Leight S, Knapik-Czajka M, Baek Y, Shaw LM, Lee VM, Trojanowski JQ, Clark CM. Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: 439-45. PMID 22571982 DOI: 10.3233/JAD-2012-120082  0.76
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Trojanowski JQ, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/hmg/dds161  0.76
2012 Hart MP, Brettschneider J, Lee VM, Trojanowski JQ, Gitler AD. Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions. Acta Neuropathologica. 124: 221-30. PMID 22526021 DOI: 10.1007/s00401-012-0985-5  0.76
2012 Toledo JB, Brettschneider J, Grossman M, Arnold SE, Hu WT, Xie SX, Lee VM, Shaw LM, Trojanowski JQ. CSF biomarkers cutoffs: the importance of coincident neuropathological diseases. Acta Neuropathologica. 124: 23-35. PMID 22526019 DOI: 10.1007/s00401-012-0983-7  0.76
2012 Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. The Journal of Experimental Medicine. 209: 975-86. PMID 22508839 DOI: 10.1084/jem.20112457  0.6
2012 Kang JH, Vanderstichele H, Trojanowski JQ, Shaw LM. Simultaneous analysis of cerebrospinal fluid biomarkers using microsphere-based xMAP multiplex technology for early detection of Alzheimer's disease. Methods (San Diego, Calif.). 56: 484-93. PMID 22503777 DOI: 10.1016/j.ymeth.2012.03.023  0.52
2012 Boxer AL, Garbutt S, Seeley WW, Jafari A, Heuer HW, Mirsky J, Hellmuth J, Trojanowski JQ, Huang E, DeArmond S, Neuhaus J, Miller BL. Saccade abnormalities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer disease. Archives of Neurology. 69: 509-17. PMID 22491196 DOI: 10.1001/archneurol.2011.1021  0.76
2012 Irwin DJ, McMillan CT, Toledo JB, Arnold SE, Shaw LM, Wang LS, Van Deerlin V, Lee VM, Trojanowski JQ, Grossman M. Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms. Archives of Neurology. 69: 1018-25. PMID 22490326 DOI: 10.1001/archneurol.2012.26  0.76
2012 Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, ... ... Trojanowski JQ, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/NEN.0b013e31825018f7  0.76
2012 Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. The Journal of Clinical Investigation. 122: 1316-38. PMID 22476197 DOI: 10.1172/JCI59903  0.76
2012 Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, ... ... Trojanowski JQ, et al. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics. 21: 2899-911. PMID 22454397 DOI: 10.1093/hmg/dds116  0.76
2012 Patel S, Lee EB, Xie SX, Law A, Jackson EM, Arnold SE, Clark CM, Shaw LM, Grady MS, Trojanowski JQ, Hamilton RH. Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus. Fluids and Barriers of the Cns. 9: 7. PMID 22444461 DOI: 10.1186/2045-8118-9-7  0.76
2012 Brettschneider J, Van Deerlin VM, Robinson JL, Kwong L, Lee EB, Ali YO, Safren N, Monteiro MJ, Toledo JB, Elman L, McCluskey L, Irwin DJ, Grossman M, Molina-Porcel L, Lee VM, ... Trojanowski JQ, et al. Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion. Acta Neuropathologica. 123: 825-39. PMID 22426854 DOI: 10.1007/s00401-012-0970-z  0.76
2012 Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB, Lee VM, Brunden KR. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3601-11. PMID 22423084 DOI: 10.1523/JNEUROSCI.4922-11.2012  0.76
2012 Jack CR, Vemuri P, Wiste HJ, Weigand SD, Lesnick TG, Lowe V, Kantarci K, Bernstein MA, Senjem ML, Gunter JL, Boeve BF, Trojanowski JQ, Shaw LM, Aisen PS, Weiner MW, et al. Shapes of the trajectories of 5 major biomarkers of Alzheimer disease. Archives of Neurology. 69: 856-67. PMID 22409939 DOI: 10.1001/archneurol.2011.3405  0.76
2012 Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chiò A, Restagno G, Nicolaou N, Simon-Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, ... ... Trojanowski JQ, et al. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. The Lancet. Neurology. 11: 323-30. PMID 22406228 DOI: 10.1016/S1474-4422(12)70043-1  0.76
2012 Irwin DJ, Cohen TJ, Grossman M, Arnold SE, Xie SX, Lee VM, Trojanowski JQ. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a Journal of Neurology. 135: 807-18. PMID 22366796 DOI: 10.1093/brain/aws013  0.76
2012 Rissman RA, Trojanowski JQ, Shaw LM, Aisen PS. Longitudinal plasma amyloid beta as a biomarker of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 119: 843-50. PMID 22354745 DOI: 10.1007/s00702-012-0772-4  0.76
2012 Wang Y, Shi M, Chung KA, Zabetian CP, Leverenz JB, Berg D, Srulijes K, Trojanowski JQ, Lee VM, Siderowf AD, Hurtig H, Litvan I, Schiess MC, Peskind ER, Masuda M, et al. Phosphorylated α-synuclein in Parkinson's disease. Science Translational Medicine. 4: 121ra20. PMID 22344688 DOI: 10.1126/scitranslmed.3002566  0.76
2012 Martinez-Lage M, Molina-Porcel L, Falcone D, McCluskey L, Lee VM, Van Deerlin VM, Trojanowski JQ. TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation. Acta Neuropathologica. 124: 285-91. PMID 22302102 DOI: 10.1007/s00401-012-0947-y  0.76
2012 Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, ... Trojanowski JQ, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 1-13. PMID 22265587 DOI: 10.1016/j.jalz.2011.10.007  0.76
2012 Brettschneider J, Libon DJ, Toledo JB, Xie SX, McCluskey L, Elman L, Geser F, Lee VM, Grossman M, Trojanowski JQ. Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis. Acta Neuropathologica. 123: 395-407. PMID 22210083 DOI: 10.1007/s00401-011-0932-x  0.76
2012 Cohen TJ, Hwang AW, Unger T, Trojanowski JQ, Lee VM. Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking. The Embo Journal. 31: 1241-52. PMID 22193716 DOI: 10.1038/emboj.2011.471  0.6
2012 Lee EB, Lee VM, Trojanowski JQ. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature Reviews. Neuroscience. 13: 38-50. PMID 22127299 DOI: 10.1038/nrn3121  0.76
2012 Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathologica. 123: 1-11. PMID 22101365 DOI: 10.1007/s00401-011-0910-3  0.76
2012 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Liu E, Morris JC, Petersen RC, Saykin AJ, Schmidt ME, Shaw L, ... ... Trojanowski JQ, et al. The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: S1-68. PMID 22047634 DOI: 10.1016/j.jalz.2011.09.172  0.76
2012 Ewers M, Insel P, Jagust WJ, Shaw L, Trojanowski JQ, Aisen P, Petersen RC, Schuff N, Weiner MW. CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects. Cerebral Cortex (New York, N.Y. : 1991). 22: 1993-2004. PMID 22038908 DOI: 10.1093/cercor/bhr271  0.32
2012 Ewers M, Schmitz S, Hansson O, Walsh C, Fitzpatrick A, Bennett D, Minthon L, Trojanowski JQ, Shaw LM, Faluyi YO, Vellas B, Dubois B, Blennow K, Buerger K, Teipel SJ, et al. Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease. Neurobiology of Aging. 33: 1599-608. PMID 21684041 DOI: 10.1016/j.neurobiolaging.2011.05.005  0.76
2012 Ewers M, Walsh C, Trojanowski JQ, Shaw LM, Petersen RC, Jack CR, Feldman HH, Bokde AL, Alexander GE, Scheltens P, Vellas B, Dubois B, Weiner M, Hampel H. Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance. Neurobiology of Aging. 33: 1203-14. PMID 21159408 DOI: 10.1016/j.neurobiolaging.2010.10.019  0.76
2011 Lee VM, Brunden KR, Hutton M, Trojanowski JQ. Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets. Cold Spring Harbor Perspectives in Medicine. 1: a006437. PMID 22229117 DOI: 10.1101/cshperspect.a006437  0.76
2011 Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A, Growdon ME, Jang JY, Huang EJ, Dearmond SJ, Trojanowski JQ, et al. Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD. Neurology. 77: 2034-42. PMID 22131541 DOI: 10.1212/WNL.0b013e31823b9c5e  0.76
2011 Robinson JL, Geser F, Corrada MM, Berlau DJ, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ. Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old. Brain : a Journal of Neurology. 134: 3708-15. PMID 22120149 DOI: 10.1093/brain/awr308  0.76
2011 Johnson VE, Stewart W, Trojanowski JQ, Smith DH. Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans. Acta Neuropathologica. 122: 715-26. PMID 22101322 DOI: 10.1007/s00401-011-0909-9  0.76
2011 Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, ... ... Trojanowski JQ, et al. A yeast functional screen predicts new candidate ALS disease genes. Proceedings of the National Academy of Sciences of the United States of America. 108: 20881-90. PMID 22065782 DOI: 10.1073/pnas.1109434108  0.76
2011 Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM. Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron. 72: 57-71. PMID 21982369 DOI: 10.1016/j.neuron.2011.08.033  0.76
2011 Carroll JC, Iba M, Bangasser DA, Valentino RJ, James MJ, Brunden KR, Lee VM, Trojanowski JQ. Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14436-49. PMID 21976528 DOI: 10.1523/JNEUROSCI.3836-11.2011  0.76
2011 Tosun D, Schuff N, Shaw LM, Trojanowski JQ, Weiner MW. Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data. Journal of Alzheimer's Disease : Jad. 26: 77-90. PMID 21971452 DOI: 10.3233/JAD-2011-0006  0.76
2011 Venneti S, Robinson JL, Roy S, White MT, Baccon J, Xie SX, Trojanowski JQ. Simulated brain biopsy for diagnosing neurodegeneration using autopsy-confirmed cases. Acta Neuropathologica. 122: 737-45. PMID 21959586 DOI: 10.1007/s00401-011-0880-5  0.76
2011 Geser F, Prvulovic D, O'Dwyer L, Hardiman O, Bede P, Bokde AL, Trojanowski JQ, Hampel H. On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia. Progress in Neurobiology. 95: 649-62. PMID 21911035 DOI: 10.1016/j.pneurobio.2011.08.011  0.76
2011 Rankin KP, Mayo MC, Seeley WW, Lee S, Rabinovici G, Gorno-Tempini ML, Boxer AL, Weiner MW, Trojanowski JQ, DeArmond SJ, Miller BL. Behavioral variant frontotemporal dementia with corticobasal degeneration pathology: phenotypic comparison to bvFTD with Pick's disease. Journal of Molecular Neuroscience : Mn. 45: 594-608. PMID 21881831 DOI: 10.1007/s12031-011-9615-2  0.76
2011 Ballatore C, Soper JH, Piscitelli F, James M, Huang L, Atasoylu O, Huryn DM, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists. Journal of Medicinal Chemistry. 54: 6969-83. PMID 21863799 DOI: 10.1021/jm200980u  0.76
2011 Jack CR, Vemuri P, Wiste HJ, Weigand SD, Aisen PS, Trojanowski JQ, Shaw LM, Bernstein MA, Petersen RC, Weiner MW, Knopman DS. Evidence for ordering of Alzheimer disease biomarkers. Archives of Neurology. 68: 1526-35. PMID 21825215 DOI: 10.1001/archneurol.2011.183  0.76
2011 Lee SE, Rabinovici GD, Mayo MC, Wilson SM, Seeley WW, DeArmond SJ, Huang EJ, Trojanowski JQ, Growdon ME, Jang JY, Sidhu M, See TM, Karydas AM, Gorno-Tempini ML, Boxer AL, et al. Clinicopathological correlations in corticobasal degeneration. Annals of Neurology. 70: 327-40. PMID 21823158 DOI: 10.1002/ana.22424  0.76
2011 Trojanowski JQ, Hampel H. Neurodegenerative disease biomarkers: guideposts for disease prevention through early diagnosis and intervention. Progress in Neurobiology. 95: 491-5. PMID 21821094 DOI: 10.1016/j.pneurobio.2011.07.004  0.76
2011 Toledo JB, Vanderstichele H, Figurski M, Aisen PS, Petersen RC, Weiner MW, Jack CR, Jagust W, Decarli C, Toga AW, Toledo E, Xie SX, Lee VM, Trojanowski JQ, Shaw LM, et al. Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI. Acta Neuropathologica. 122: 401-13. PMID 21805181 DOI: 10.1007/s00401-011-0861-8  0.76
2011 Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, ... ... Trojanowski JQ, et al. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 386-395.e6. PMID 21784349 DOI: 10.1016/j.jalz.2011.05.2243  0.76
2011 Xie SX, Baek Y, Grossman M, Arnold SE, Karlawish J, Siderowf A, Hurtig H, Elman L, McCluskey L, Van Deerlin V, Lee VM, Trojanowski JQ. Building an integrated neurodegenerative disease database at an academic health center. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: e84-93. PMID 21784346 DOI: 10.1016/j.jalz.2010.08.233  0.76
2011 Cohen TJ, Lee VM, Trojanowski JQ. TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies. Trends in Molecular Medicine. 17: 659-67. PMID 21783422 DOI: 10.1016/j.molmed.2011.06.004  0.6
2011 Wolk DA, Grachev ID, Buckley C, Kazi H, Grady MS, Trojanowski JQ, Hamilton RH, Sherwin P, McLain R, Arnold SE. Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology. Archives of Neurology. 68: 1398-403. PMID 21747004 DOI: 10.1001/archneurol.2011.153  0.76
2011 Lim Y, Kehm VM, Lee EB, Soper JH, Li C, Trojanowski JQ, Lee VM. α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10076-87. PMID 21734300 DOI: 10.1523/JNEUROSCI.0618-11.2011  0.76
2011 Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K, Karatsu Y, Iwamoto Y, Miyakawa T, Suhara T, Trojanowski JQ, Lee VM, Takahashi R. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. Plos One. 6: e21050. PMID 21698260 DOI: 10.1371/journal.pone.0021050  0.76
2011 Lo RY, Hubbard AE, Shaw LM, Trojanowski JQ, Petersen RC, Aisen PS, Weiner MW, Jagust WJ. Longitudinal change of biomarkers in cognitive decline. Archives of Neurology. 68: 1257-66. PMID 21670386 DOI: 10.1001/archneurol.2011.123  0.76
2011 Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E, Perry RH, Trojanowski JQ, Mann DM, Lee VM. A harmonized classification system for FTLD-TDP pathology. Acta Neuropathologica. 122: 111-3. PMID 21644037 DOI: 10.1007/s00401-011-0845-8  0.76
2011 Winton MJ, Lee EB, Sun E, Wong MM, Leight S, Zhang B, Trojanowski JQ, Lee VM. Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7691-9. PMID 21613482 DOI: 10.1523/JNEUROSCI.6637-10.2011  0.76
2011 Fagan AM, Shaw LM, Xiong C, Vanderstichele H, Mintun MA, Trojanowski JQ, Coart E, Morris JC, Holtzman DM. Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology. Archives of Neurology. 68: 1137-44. PMID 21555603 DOI: 10.1001/archneurol.2011.105  0.76
2011 Hu WT, Trojanowski JQ, Shaw LM. Biomarkers in frontotemporal lobar degenerations--progress and challenges. Progress in Neurobiology. 95: 636-48. PMID 21554923 DOI: 10.1016/j.pneurobio.2011.04.012  0.76
2011 Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6850-7. PMID 21543615 DOI: 10.1523/JNEUROSCI.6467-10.2011  0.76
2011 Chen-Plotkin AS, Hu WT, Siderowf A, Weintraub D, Goldmann Gross R, Hurtig HI, Xie SX, Arnold SE, Grossman M, Clark CM, Shaw LM, McCluskey L, Elman L, Van Deerlin VM, Lee VM, ... ... Trojanowski JQ, et al. Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Annals of Neurology. 69: 655-63. PMID 21520231 DOI: 10.1002/ana.22271  0.76
2011 Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL, Brooks WS, Halliday GM, Kril JJ, ... ... Trojanowski JQ, et al. Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Archives of Neurology. 68: 488-97. PMID 21482928 DOI: 10.1001/archneurol.2011.53  0.76
2011 Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, et al. Harnessing neuroplasticity for clinical applications. Brain : a Journal of Neurology. 134: 1591-609. PMID 21482550 DOI: 10.1093/brain/awr039  0.76
2011 Yu Z, Zhu Y, Chen-Plotkin AS, Clay-Falcone D, McCluskey L, Elman L, Kalb RG, Trojanowski JQ, Lee VM, Van Deerlin VM, Gitler AD, Bonini NM. PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats. Plos One. 6: e17951. PMID 21479228 DOI: 10.1371/journal.pone.0017951  0.76
2011 Vemuri P, Weigand SD, Przybelski SA, Knopman DS, Smith GE, Trojanowski JQ, Shaw LM, Decarli CS, Carmichael O, Bernstein MA, Aisen PS, Weiner M, Petersen RC, Jack CR. Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition. Brain : a Journal of Neurology. 134: 1479-92. PMID 21478184 DOI: 10.1093/brain/awr049  0.76
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Trojanowski JQ, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/ng.801  0.76
2011 Pesiridis GS, Tripathy K, Tanik S, Trojanowski JQ, Lee VM. A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport. The Journal of Biological Chemistry. 286: 18845-55. PMID 21454607 DOI: 10.1074/jbc.M111.231118  0.76
2011 Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, et al. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4720-30. PMID 21430171 DOI: 10.1523/JNEUROSCI.3076-10.2011  0.76
2011 Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ, Lee VM. The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nature Communications. 2: 252. PMID 21427723 DOI: 10.1038/ncomms1255  0.76
2011 Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB, Huryn DM. Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies. Current Topics in Medicinal Chemistry. 11: 317-30. PMID 21320060 DOI: 10.2174/156802611794072605  0.76
2011 Shaw LM, Vanderstichele H, Knapik-Czajka M, Figurski M, Coart E, Blennow K, Soares H, Simon AJ, Lewczuk P, Dean RA, Siemers E, Potter W, Lee VM, Trojanowski JQ. Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI. Acta Neuropathologica. 121: 597-609. PMID 21311900 DOI: 10.1007/s00401-011-0808-0  0.76
2011 Weigand SD, Vemuri P, Wiste HJ, Senjem ML, Pankratz VS, Aisen PS, Weiner MW, Petersen RC, Shaw LM, Trojanowski JQ, Knopman DS, Jack CR. Transforming cerebrospinal fluid Aβ42 measures into calculated Pittsburgh Compound B units of brain Aβ amyloid. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 133-41. PMID 21282074 DOI: 10.1016/j.jalz.2010.08.230  0.76
2011 Chen K, Ayutyanont N, Langbaum JB, Fleisher AS, Reschke C, Lee W, Liu X, Bandy D, Alexander GE, Thompson PM, Shaw L, Trojanowski JQ, Jack CR, Landau SM, Foster NL, et al. Characterizing Alzheimer's disease using a hypometabolic convergence index. Neuroimage. 56: 52-60. PMID 21276856 DOI: 10.1016/j.neuroimage.2011.01.049  0.76
2011 Geser F, Stein B, Partain M, Elman LB, McCluskey LF, Xie SX, Van Deerlin VM, Kwong LK, Lee VM, Trojanowski JQ. Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy. Acta Neuropathologica. 121: 509-17. PMID 21225272 DOI: 10.1007/s00401-011-0797-z  0.76
2011 Okonkwo OC, Mielke MM, Griffith HR, Moghekar AR, O'Brien RJ, Shaw LM, Trojanowski JQ, Albert MS. Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment. Archives of Neurology. 68: 113-9. PMID 21220682 DOI: 10.1001/archneurol.2010.334  0.76
2011 Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of Clinical Investigation. 121: 726-38. PMID 21206091 DOI: 10.1172/JCI44867  0.76
2011 Brunden KR, Yao Y, Potuzak JS, Ferrer NI, Ballatore C, James MJ, Hogan AM, Trojanowski JQ, Smith AB, Lee VM. The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 63: 341-51. PMID 21163349 DOI: 10.1016/j.phrs.2010.12.002  0.6
2011 Kim S, Swaminathan S, Shen L, Risacher SL, Nho K, Foroud T, Shaw LM, Trojanowski JQ, Potkin SG, Huentelman MJ, Craig DW, DeChairo BM, Aisen PS, Petersen RC, Weiner MW, et al. Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology. 76: 69-79. PMID 21123754 DOI: 10.1212/WNL.0b013e318204a397  0.76
2011 Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena SC, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ. Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity. Journal of the Neurological Sciences. 301: 112-5. PMID 21112060 DOI: 10.1016/j.jns.2010.10.014  0.76
2011 Vass R, Ashbridge E, Geser F, Hu WT, Grossman M, Clay-Falcone D, Elman L, McCluskey L, Lee VM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS. Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis. Acta Neuropathologica. 121: 373-80. PMID 21104415 DOI: 10.1007/s00401-010-0782-y  0.76
2011 Geser F, Malunda JA, Hurtig HI, Duda JE, Wenning GK, Gilman S, Low PA, Lee VM, Trojanowski JQ. TDP-43 pathology occurs infrequently in multiple system atrophy. Neuropathology and Applied Neurobiology. 37: 358-65. PMID 20942898 DOI: 10.1111/j.1365-2990.2010.01136.x  0.6
2011 Haris M, Singh A, Cai K, Davatzikos C, Trojanowski JQ, Melhem ER, Clark CM, Borthakur A. T1rho (T1ρ) MR imaging in Alzheimer's disease and Parkinson's disease with and without dementia. Journal of Neurology. 258: 380-5. PMID 20924593 DOI: 10.1007/s00415-010-5762-6  0.76
2011 Davatzikos C, Bhatt P, Shaw LM, Batmanghelich KN, Trojanowski JQ. Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification. Neurobiology of Aging. 32: 2322.e19-27. PMID 20594615 DOI: 10.1016/j.neurobiolaging.2010.05.023  0.52
2011 Haris M, Singh A, Cai K, McArdle E, Fenty M, Davatzikos C, Trojanowski JQ, Melhem ER, Clark CM, Borthakur A. T(1ρ) MRI in Alzheimer's disease: detection of pathological changes in medial temporal lobe. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. 21: e86-90. PMID 20331502 DOI: 10.1111/j.1552-6569.2010.00467.x  0.76
2010 Rohrer JD, Geser F, Zhou J, Gennatas ED, Sidhu M, Trojanowski JQ, Dearmond SJ, Miller BL, Seeley WW. TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia. Neurology. 75: 2204-11. PMID 21172843 DOI: 10.1212/WNL.0b013e318202038c  0.76
2010 Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, et al. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 68: 857-64. PMID 21145000 DOI: 10.1016/j.neuron.2010.11.036  0.76
2010 Hu WT, Chen-Plotkin A, Grossman M, Arnold SE, Clark CM, Shaw LM, McCluskey L, Elman L, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ. Novel CSF biomarkers for frontotemporal lobar degenerations. Neurology. 75: 2079-86. PMID 21048198 DOI: 10.1212/WNL.0b013e318200d78d  0.76
2010 Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ, Xie SX, Ballatore C, Smith AB, Lee VM, Trojanowski JQ. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13861-6. PMID 20943926 DOI: 10.1523/JNEUROSCI.3059-10.2010  0.76
2010 Geser F, Robinson JL, Malunda JA, Xie SX, Clark CM, Kwong LK, Moberg PJ, Moore EM, Van Deerlin VM, Lee VM, Arnold SE, Trojanowski JQ. Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness. Archives of Neurology. 67: 1238-50. PMID 20937952 DOI: 10.1001/archneurol.2010.254  0.76
2010 Jack CR, Wiste HJ, Vemuri P, Weigand SD, Senjem ML, Zeng G, Bernstein MA, Gunter JL, Pankratz VS, Aisen PS, Weiner MW, Petersen RC, Shaw LM, Trojanowski JQ, Knopman DS, et al. Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease. Brain : a Journal of Neurology. 133: 3336-48. PMID 20935035 DOI: 10.1093/brain/awq277  0.76
2010 Hu WT, Wang Z, Lee VM, Trojanowski JQ, Detre JA, Grossman M. Distinct cerebral perfusion patterns in FTLD and AD. Neurology. 75: 881-8. PMID 20819999 DOI: 10.1212/WNL.0b013e3181f11e35  0.76
2010 Hurtado DE, Molina-Porcel L, Iba M, Aboagye AK, Paul SM, Trojanowski JQ, Lee VM. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. The American Journal of Pathology. 177: 1977-88. PMID 20802182 DOI: 10.2353/ajpath.2010.100346  0.76
2010 Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, ... ... Trojanowski JQ, et al. Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature. 466: 1069-75. PMID 20740007 DOI: 10.1038/nature09320  0.76
2010 Siderowf A, Xie SX, Hurtig H, Weintraub D, Duda J, Chen-Plotkin A, Shaw LM, Van Deerlin V, Trojanowski JQ, Clark C. CSF amyloid {beta} 1-42 predicts cognitive decline in Parkinson disease. Neurology. 75: 1055-61. PMID 20720189 DOI: 10.1212/WNL.0b013e3181f39a78  0.76
2010 Hu WT, McMillan C, Libon D, Leight S, Forman M, Lee VM, Trojanowski JQ, Grossman M. Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia. Neurology. 75: 595-602. PMID 20713948 DOI: 10.1212/WNL.0b013e3181ed9c52  0.76
2010 De Meyer G, Shapiro F, Vanderstichele H, Vanmechelen E, Engelborghs S, De Deyn PP, Coart E, Hansson O, Minthon L, Zetterberg H, Blennow K, Shaw L, Trojanowski JQ. Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people. Archives of Neurology. 67: 949-56. PMID 20697045 DOI: 10.1001/archneurol.2010.179  0.76
2010 Hamilton R, Patel S, Lee EB, Jackson EM, Lopinto J, Arnold SE, Clark CM, Basil A, Shaw LM, Xie SX, Grady MS, Trojanowski JQ. Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology. Annals of Neurology. 68: 535-40. PMID 20687117 DOI: 10.1002/ana.22015  0.76
2010 Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ. Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease. Acta Neuropathologica. 120: 385-99. PMID 20652578 DOI: 10.1007/s00401-010-0723-9  0.76
2010 Korecka M, Clark CM, Lee VM, Trojanowski JQ, Shaw LM. Simultaneous HPLC-MS-MS quantification of 8-iso-PGF(2alpha) and 8,12-iso-iPF(2alpha) in CSF and brain tissue samples with on-line cleanup. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 878: 2209-16. PMID 20643588 DOI: 10.1016/j.jchromb.2010.06.029  0.76
2010 Vemuri P, Wiste HJ, Weigand SD, Knopman DS, Trojanowski JQ, Shaw LM, Bernstein MA, Aisen PS, Weiner M, Petersen RC, Jack CR. Serial MRI and CSF biomarkers in normal aging, MCI, and AD. Neurology. 75: 143-51. PMID 20625167 DOI: 10.1212/WNL.0b013e3181e7ca82  0.76
2010 Chou YY, Leporé N, Saharan P, Madsen SK, Hua X, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW, Toga AW, Thompson PM. Ventricular maps in 804 ADNI subjects: correlations with CSF biomarkers and clinical decline. Neurobiology of Aging. 31: 1386-400. PMID 20620663 DOI: 10.1016/j.neurobiolaging.2010.05.001  0.76
2010 Landau SM, Harvey D, Madison CM, Reiman EM, Foster NL, Aisen PS, Petersen RC, Shaw LM, Trojanowski JQ, Jack CR, Weiner MW, Jagust WJ. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology. 75: 230-8. PMID 20592257 DOI: 10.1212/WNL.0b013e3181e8e8b8  0.76
2010 Huang EJ, Zhang J, Geser F, Trojanowski JQ, Strober JB, Dickson DW, Brown RH, Shapiro BE, Lomen-Hoerth C. Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions. Brain Pathology (Zurich, Switzerland). 20: 1069-76. PMID 20579074 DOI: 10.1111/j.1750-3639.2010.00413.x  0.76
2010 Tosun D, Schuff N, Truran-Sacrey D, Shaw LM, Trojanowski JQ, Aisen P, Peterson R, Weiner MW. Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study. Neurobiology of Aging. 31: 1340-54. PMID 20570401 DOI: 10.1016/j.neurobiolaging.2010.04.030  0.76
2010 Okonkwo OC, Alosco ML, Griffith HR, Mielke MM, Shaw LM, Trojanowski JQ, Tremont G. Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer disease. Archives of Neurology. 67: 688-96. PMID 20558388 DOI: 10.1001/archneurol.2010.118  0.76
2010 Nettiksimmons J, Harvey D, Brewer J, Carmichael O, DeCarli C, Jack CR, Petersen R, Shaw LM, Trojanowski JQ, Weiner MW, Beckett L. Subtypes based on cerebrospinal fluid and magnetic resonance imaging markers in normal elderly predict cognitive decline. Neurobiology of Aging. 31: 1419-28. PMID 20542598 DOI: 10.1016/j.neurobiolaging.2010.04.025  0.76
2010 Apostolova LG, Hwang KS, Andrawis JP, Green AE, Babakchanian S, Morra JH, Cummings JL, Toga AW, Trojanowski JQ, Shaw LM, Jack CR, Petersen RC, Aisen PS, Jagust WJ, Koeppe RA, et al. 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects. Neurobiology of Aging. 31: 1284-303. PMID 20538372 DOI: 10.1016/j.neurobiolaging.2010.05.003  0.76
2010 Ritson GP, Custer SK, Freibaum BD, Guinto JB, Geffel D, Moore J, Tang W, Winton MJ, Neumann M, Trojanowski JQ, Lee VM, Forman MS, Taylor JP. TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7729-39. PMID 20519548 DOI: 10.1523/JNEUROSCI.5894-09.2010  0.76
2010 Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7281-9. PMID 20505094 DOI: 10.1523/JNEUROSCI.0490-10.2010  0.76
2010 Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, Dickson DW, Rademakers R, ... ... Trojanowski JQ, et al. FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. Acta Neuropathologica. 120: 33-41. PMID 20490813 DOI: 10.1007/s00401-010-0698-6  0.76
2010 Aisen PS, Petersen RC, Donohue MC, Gamst A, Raman R, Thomas RG, Walter S, Trojanowski JQ, Shaw LM, Beckett LA, Jack CR, Jagust W, Toga AW, Saykin AJ, Morris JC, et al. Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 239-46. PMID 20451872 DOI: 10.1016/j.jalz.2010.03.006  0.76
2010 Trojanowski JQ, Vandeerstichele H, Korecka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers E, Potter WZ, Weiner MW, Jack CR, et al. Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 230-8. PMID 20451871 DOI: 10.1016/j.jalz.2010.03.008  0.76
2010 Weiner MW, Aisen PS, Jack CR, Jagust WJ, Trojanowski JQ, Shaw L, Saykin AJ, Morris JC, Cairns N, Beckett LA, Toga A, Green R, Walter S, Soares H, Snyder P, et al. The Alzheimer's disease neuroimaging initiative: progress report and future plans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 202-11.e7. PMID 20451868 DOI: 10.1016/j.jalz.2010.03.007  0.76
2010 Arnold SE, Lee EB, Moberg PJ, Stutzbach L, Kazi H, Han LY, Lee VM, Trojanowski JQ. Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease. Annals of Neurology. 67: 462-9. PMID 20437581 DOI: 10.1002/ana.21910  0.76
2010 Garbern JY, Neumann M, Trojanowski JQ, Lee VM, Feldman G, Norris JW, Friez MJ, Schwartz CE, Stevenson R, Sima AA. A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition. Brain : a Journal of Neurology. 133: 1391-402. PMID 20395263 DOI: 10.1093/brain/awq071  0.76
2010 Ballatore C, Brunden KR, Piscitelli F, James MJ, Crowe A, Yao Y, Hyde E, Trojanowski JQ, Lee VM, Smith AB. Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation. Journal of Medicinal Chemistry. 53: 3739-47. PMID 20392114 DOI: 10.1021/jm100138f  0.6
2010 Vemuri P, Wiste HJ, Weigand SD, Knopman DS, Shaw LM, Trojanowski JQ, Aisen PS, Weiner M, Petersen RC, Jack CR. Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease. Annals of Neurology. 67: 308-16. PMID 20373342 DOI: 10.1002/ana.21953  0.76
2010 Uryu K, Haddix T, Robinson J, Nakashima-Yasuda H, Lee VM, Trojanowski JQ. Burden of neurodegenerative diseases in a cohort of medical examiner subjects. Journal of Forensic Sciences. 55: 642-5. PMID 20345790 DOI: 10.1111/j.1556-4029.2010.01347.x  0.6
2010 Trojanowski JQ, Arnold SE, Karlawish JH, Brunden K, Cary M, Davatzikos C, Detre J, Gaulton G, Grossman M, Hurtig H, Jedrziewski K, McCluskey L, Naylor M, Polsky D, Schellenberg GD, et al. Design of comprehensive Alzheimer's disease centers to address unmet national needs. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 150-5. PMID 20298979 DOI: 10.1016/j.jalz.2009.11.004  0.76
2010 Xu S, Brunden KR, Trojanowski JQ, Lee VM. Characterization of tau fibrillization in vitro. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 110-7. PMID 20298971 DOI: 10.1016/j.jalz.2009.06.002  0.6
2010 Chen-Plotkin AS, Lee VM, Trojanowski JQ. TAR DNA-binding protein 43 in neurodegenerative disease. Nature Reviews. Neurology. 6: 211-20. PMID 20234357 DOI: 10.1038/nrneurol.2010.18  0.6
2010 Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, Pickering E, Kuhn M, Chen Y, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, ... ... Trojanowski JQ, et al. Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment. Acta Neuropathologica. 119: 669-78. PMID 20232070 DOI: 10.1007/s00401-010-0667-0  0.76
2010 Kraemer BC, Schuck T, Wheeler JM, Robinson LC, Trojanowski JQ, Lee VM, Schellenberg GD. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathologica. 119: 409-19. PMID 20198480 DOI: 10.1007/s00401-010-0659-0  0.76
2010 Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, ... ... Trojanowski JQ, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics. 42: 234-9. PMID 20154673 DOI: 10.1038/ng.536  0.88
2010 Yu CE, Bird TD, Bekris LM, Montine TJ, Leverenz JB, Steinbart E, Galloway NM, Feldman H, Woltjer R, Miller CA, Wood EM, Grossman M, McCluskey L, Clark CM, Neumann M, ... ... Trojanowski JQ, et al. The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. Archives of Neurology. 67: 161-70. PMID 20142524 DOI: 10.1001/archneurol.2009.328  0.76
2010 Geser F, Lee VM, Trojanowski JQ. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 30: 103-12. PMID 20102519 DOI: 10.1111/j.1440-1789.2009.01091.x  0.6
2010 Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. The Lancet. Neurology. 9: 119-28. PMID 20083042 DOI: 10.1016/S1474-4422(09)70299-6  0.76
2010 Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, Jack CR, Jagust WJ, Shaw LM, Toga AW, Trojanowski JQ, Weiner MW. Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization. Neurology. 74: 201-9. PMID 20042704 DOI: 10.1212/WNL.0b013e3181cb3e25  0.76
2010 Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, Ince PG, Kamphorst W, Revesz T, Rozemuller AJ, Kumar-Singh S, ... ... Trojanowski JQ, et al. Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathologica. 119: 1-4. PMID 19924424 DOI: 10.1007/s00401-009-0612-2  0.76
2010 Hampel H, Blennow K, Shaw LM, Hoessler YC, Zetterberg H, Trojanowski JQ. Total and phosphorylated tau protein as biological markers of Alzheimer's disease. Experimental Gerontology. 45: 30-40. PMID 19853650 DOI: 10.1016/j.exger.2009.10.010  0.52
2010 Lim Y, Kehm VM, Li C, Trojanowski JQ, Lee VM. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Experimental Neurology. 221: 86-97. PMID 19833127 DOI: 10.1016/j.expneurol.2009.10.005  0.76
2010 Hampel H, Shen Y, Walsh DM, Aisen P, Shaw LM, Zetterberg H, Trojanowski JQ, Blennow K. Biological markers of amyloid beta-related mechanisms in Alzheimer's disease. Experimental Neurology. 223: 334-46. PMID 19815015 DOI: 10.1016/j.expneurol.2009.09.024  0.52
2010 Brunden KR, Ballatore C, Crowe A, Smith AB, Lee VM, Trojanowski JQ. Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors. Experimental Neurology. 223: 304-10. PMID 19744482 DOI: 10.1016/j.expneurol.2009.08.031  0.6
2010 Chen-Plotkin AS, Xiao J, Geser F, Martinez-Lage M, Grossman M, Unger T, Wood EM, Van Deerlin VM, Trojanowski JQ, Lee VM. Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Acta Neuropathologica. 119: 111-22. PMID 19649643 DOI: 10.1007/s00401-009-0576-2  0.76
2009 Lippa CF, Rosso AL, Stutzbach LD, Neumann M, Lee VM, Trojanowski JQ. Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome. Archives of Neurology. 66: 1483-8. PMID 20008652 DOI: 10.1001/archneurol.2009.277  0.76
2009 Portelius E, Zhang B, Gustavsson MK, Brinkmalm G, Westman-Brinkmalm A, Zetterberg H, Lee VM, Trojanowski JQ, Blennow K. Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease. Neuro-Degenerative Diseases. 6: 258-62. PMID 19955704 DOI: 10.1159/000264639  0.6
2009 Hu WT, Seelaar H, Josephs KA, Knopman DS, Boeve BF, Sorenson EJ, McCluskey L, Elman L, Schelhaas HJ, Parisi JE, Kuesters B, Lee VM, Trojanowski JQ, Petersen RC, van Swieten JC, et al. Survival profiles of patients with frontotemporal dementia and motor neuron disease. Archives of Neurology. 66: 1359-64. PMID 19901167 DOI: 10.1001/archneurol.2009.253  0.76
2009 Luk KC, Song C, O'Brien P, Stieber A, Branch JR, Brunden KR, Trojanowski JQ, Lee VM. Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 20051-6. PMID 19892735 DOI: 10.1073/pnas.0908005106  0.6
2009 Jagust WJ, Landau SM, Shaw LM, Trojanowski JQ, Koeppe RA, Reiman EM, Foster NL, Petersen RC, Weiner MW, Price JC, Mathis CA. Relationships between biomarkers in aging and dementia. Neurology. 73: 1193-9. PMID 19822868 DOI: 10.1212/WNL.0b013e3181bc010c  0.76
2009 Pesiridis GS, Lee VM, Trojanowski JQ. Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis. Human Molecular Genetics. 18: R156-62. PMID 19808791 DOI: 10.1093/hmg/ddp303  0.76
2009 Brunden KR, Trojanowski JQ, Lee VM. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nature Reviews. Drug Discovery. 8: 783-93. PMID 19794442 DOI: 10.1038/nrd2959  0.6
2009 Geser F, Martinez-Lage M, Kwong LK, Lee VM, Trojanowski JQ. Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases. Journal of Neurology. 256: 1205-14. PMID 19271105 DOI: 10.1007/s00415-009-5069-7  0.76
2009 Geser F, Martinez-Lage M, Robinson J, Uryu K, Neumann M, Brandmeir NJ, Xie SX, Kwong LK, Elman L, McCluskey L, Clark CM, Malunda J, Miller BL, Zimmerman EA, Qian J, ... ... Trojanowski JQ, et al. Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Archives of Neurology. 66: 180-9. PMID 19204154 DOI: 10.1001/archneurol.2008.558  0.76
2009 Igaz LM, Kwong LK, Chen-Plotkin A, Winton MJ, Unger TL, Xu Y, Neumann M, Trojanowski JQ, Lee VM. Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies. The Journal of Biological Chemistry. 284: 8516-24. PMID 19164285 DOI: 10.1074/jbc.M809462200  0.76
2009 McCluskey LF, Elman LB, Martinez-Lage M, Van Deerlin V, Yuan W, Clay D, Siderowf A, Trojanowski JQ. Amyotrophic lateral sclerosis-plus syndrome with TAR DNA-binding protein-43 pathology Archives of Neurology. 66: 121-124. PMID 19139310 DOI: 10.1001/archneur.66.1.121  0.76
2009 Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, Lee VM. Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathologica. 117: 137-49. PMID 19125255 DOI: 10.1007/s00401-008-0477-9  0.76
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