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John Q. Trojanowski, MD,Tufts University, PhD, Tufts University 1976 - Publications

Affiliations: 
Pathology and Laboratory Medicine University of Pennsylvania, Philadelphia, PA, United States 
Area:
Neurodegenerative diseases
Website:
http://pathology.uphs.upenn.edu/Faculty/FacultyInfo.aspx?site=FacultyList&dept=Faculty&id=17800

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Shantaraman A, Dammer EB, Ugochukwu O, Duong DM, Yin L, Carter EK, Gearing M, Chen-Plotkin A, Lee EB, Trojanowski JQ, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Higginbotham L. Correction: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer's disease. Molecular Neurodegeneration. 19: 71. PMID 39394136 DOI: 10.1186/s13024-024-00765-1  0.718
2024 Khandelwal P, Duong MT, Sadaghiani S, Lim S, Denning AE, Chung E, Ravikumar S, Arezoumandan S, Peterson C, Bedard M, Capp N, Ittyerah R, Migdal E, Choi G, Kopp E, ... ... Trojanowski JQ, et al. Automated deep learning segmentation of high-resolution 7 Tesla postmortem MRI for quantitative analysis of structure-pathology correlations in neurodegenerative diseases. Imaging Neuroscience (Cambridge, Mass.). 2: 1-30. PMID 39301426 DOI: 10.1162/imag_a_00171  0.792
2024 Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Han X, Yamakawa M, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, ... ... Trojanowski JQ, et al. Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics. Cell. PMID 39265576 DOI: 10.1016/j.cell.2024.08.019  0.611
2024 Shantaraman A, Dammer EB, Ugochukwu O, Duong DM, Yin L, Carter EK, Gearing M, Chen-Plotkin A, Lee EB, Trojanowski JQ, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Higginbotham L. Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer's disease. Molecular Neurodegeneration. 19: 60. PMID 39107789 DOI: 10.1186/s13024-024-00749-1  0.742
2024 Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, ... ... Trojanowski JQ, et al. Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing. Medrxiv : the Preprint Server For Health Sciences. PMID 38978643 DOI: 10.1101/2024.06.24.24309088  0.799
2024 Henderson MX, Sengupta M, Trojanowski JQ, Lee VMY. Correction to: Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease. Acta Neuropathologica Communications. 12: 110. PMID 38943188 DOI: 10.1186/s40478-024-01819-7  0.326
2024 Nazeen S, Wang X, Zielinski D, Lam I, Hallacli E, Xu P, Ethier E, Strom R, Zanella CA, Nithianandam V, Ritter D, Henderson A, Saurat N, Afroz J, Nutter-Upham A, ... ... Trojanowski JQ, et al. Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies. Biorxiv : the Preprint Server For Biology. PMID 38496508 DOI: 10.1101/2024.03.03.583145  0.601
2024 Xu H, Qiu Q, Hu P, Hoxha K, Jang E, O'Reilly M, Kim C, He Z, Marotta N, Changolkar L, Zhang B, Wu H, Schellenberg GD, Kraemer B, Luk KC, ... ... Trojanowski JQ, et al. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta Neuropathologica. 147: 55. PMID 38472475 DOI: 10.1007/s00401-024-02703-3  0.687
2024 Shantaraman A, Dammer EB, Ugochukwu O, Duong DM, Yin L, Carter EK, Gearing M, Chen-Plotkin A, Lee EB, Trojanowski JQ, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Higginbotham L. Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer's Disease. Biorxiv : the Preprint Server For Biology. PMID 38328211 DOI: 10.1101/2024.01.23.576728  0.742
2023 Phillips JS, Robinson JL, Cousins KAQ, Wolk DA, Lee EB, McMillan CT, Trojanowski JQ, Grossman M, Irwin DJ. Polypathologic associations with grey matter atrophy in neurodegenerative disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 38050082 DOI: 10.1523/JNEUROSCI.0808-23.2023  0.808
2023 Bassil F, Brown HJ, Pattabhiraman S, Iwasyk JE, Maghames CM, Meymand ES, Cox TO, Riddle DM, Zhang B, Trojanowski JQ, Lee VM. Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology. Neuron. 111: 3699. PMID 37972565 DOI: 10.1016/j.neuron.2023.10.030  0.466
2023 Uemura N, Marotta NP, Ara J, Meymand ES, Zhang B, Kameda H, Koike M, Luk KC, Trojanowski JQ, Lee VM. α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice. Nature Communications. 14: 6892. PMID 37898614 DOI: 10.1038/s41467-023-42705-5  0.432
2023 Zhang S, Zhu R, Pan B, Xu H, Olufemi MF, Gathagan RJ, Li Y, Zhang L, Zhang J, Xiang W, Kagan EM, Cao X, Yuan C, Kim SJ, Williams CK, ... ... Trojanowski JQ, et al. Author Correction: Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature Neuroscience. PMID 37814027 DOI: 10.1038/s41593-023-01474-6  0.35
2023 Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, ... ... Trojanowski JQ, et al. Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics. Biorxiv : the Preprint Server For Biology. PMID 37808727 DOI: 10.1101/2023.09.29.560245  0.607
2023 Zhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, McBride JD, Duan J, Deng J, Zhang B, Kim SJ, Zoll B, Saito T, Sasaguri H, Saido TC, ... ... Trojanowski JQ, et al. A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. Science Translational Medicine. 15: eabo6889. PMID 37703352 DOI: 10.1126/scitranslmed.abo6889  0.512
2023 Zhang ZY, Harischandra DS, Wang R, Ghaisas S, Zhao JY, McMonagle TP, Zhu G, Lacuarta KD, Song J, Trojanowski JQ, Xu H, Lee VM, Yang X. TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease. Science (New York, N.Y.). 381: eadd6696. PMID 37499037 DOI: 10.1126/science.add6696  0.562
2023 Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, ... ... Trojanowski JQ, et al. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies and nominates ancestry-specific loci , , and as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. Medrxiv : the Preprint Server For Health Sciences. PMID 37461624 DOI: 10.1101/2023.07.06.23292311  0.736
2023 Ash S, Nevler N, Irwin DJ, Shellikeri S, Rascovsky K, Shaw L, Lee EB, Trojanowski JQ, Grossman M. Apraxia of Speech in the Spontaneous Speech of Nonfluent/Agrammatic Primary Progressive Aphasia. Journal of Alzheimer's Disease Reports. 7: 589-604. PMID 37313492 DOI: 10.3233/ADR-220089  0.638
2023 Chen M, Burke S, Olm CA, Irwin DJ, Massimo L, Lee EB, Trojanowski JQ, Gee JC, Grossman M. Antemortem network analysis of spreading pathology in autopsy-confirmed frontotemporal degeneration. Brain Communications. 5: fcad147. PMID 37223129 DOI: 10.1093/braincomms/fcad147  0.738
2023 Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, ... ... Trojanowski JQ, et al. Creating the Pick's disease International Consortium: Association study of H2 haplotype with risk of Pick's disease. Medrxiv : the Preprint Server For Health Sciences. PMID 37163045 DOI: 10.1101/2023.04.17.23288471  0.817
2023 Giannini LAA, Ohm DT, Rozemuller AJM, Dratch L, Suh E, van Deerlin VM, Trojanowski JQ, Lee EB, van Swieten JC, Grossman M, Seelaar H, Irwin DJ. Correction to: Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta Neuropathologica. PMID 36930297 DOI: 10.1007/s00401-023-02556-2  0.803
2023 Robinson JL, Xie SX, Baer DR, Suh E, Van Deerlin VM, Loh NJ, Irwin D, McMillan CT, Wolk D, Chen-Plotkin A, Weintraub D, Schuck T, Lee VM, Trojanowski JQ, Lee EB. Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated. Brain : a Journal of Neurology. PMID 36864661 DOI: 10.1093/brain/awad059  0.815
2023 Uemura N, Marotta N, Ara J, Meymand E, Zhang B, Kameda H, Koike M, Luk K, Trojanowski J, Lee V. Distinct biological activity of Lewy body α-Synuclein strain in mice. Research Square. PMID 36824782 DOI: 10.21203/rs.3.rs-2579805/v1  0.414
2023 Zhang S, Zhu R, Pan B, Xu H, Olufemi MF, Gathagan RJ, Li Y, Zhang L, Zhang J, Xiang W, Kagan EM, Cao X, Yuan C, Kim SJ, Williams CK, ... ... Trojanowski JQ, et al. Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature Neuroscience. PMID 36690898 DOI: 10.1038/s41593-022-01239-7  0.401
2022 Robinson JL, Richardson H, Xie SX, Alfaro B, Loh N, Lee VM, Lee EB, Trojanowski JQ. Cerebrovascular disease lesions are additive and tied to vascular risk factors and cognitive impairment. Free Neuropathology. 3. PMID 37250748 DOI: 10.17879/freeneuropathology-2022-3792  0.641
2022 Tropea TF, Waligorska T, Xie SX, Nasrallah IM, Cousins KAQ, Trojanowski JQ, Grossman M, Irwin DJ, Weintraub D, Lee EB, Wolk DA, Chen-Plotkin AS, Shaw LM. Plasma phosphorylated tau181 predicts cognitive and functional decline. Annals of Clinical and Translational Neurology. PMID 36518085 DOI: 10.1002/acn3.51695  0.781
2022 Olm CA, Burke SE, Peterson C, Lee EB, Trojanowski JQ, Massimo L, Irwin DJ, Grossman M, Gee JC. Event-based modeling of T1-weighted MRI is related to pathology in frontotemporal lobar degeneration due to tau and TDP. Neuroimage. Clinical. 37: 103285. PMID 36508888 DOI: 10.1016/j.nicl.2022.103285  0.718
2022 Sadaghiani S, Trotman W, Lim SA, Chung E, Ittyerah R, Ravikumar S, Khandelwal P, Prabhakaran K, Lavery ML, Ohm DT, Gabrielyan M, Das SR, Schuck T, Capp N, Peterson CS, ... ... Trojanowski JQ, et al. Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36464907 DOI: 10.1002/alz.12884  0.803
2022 Uemura MT, Suh ER, Robinson JL, Brunden KR, Grossman M, Irwin DJ, Lee VM, Trojanowski JQ, Lee EB, Van Deerlin VM. Abundant co-pathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions, and ageing-related tau astrogliopathy in a family with a GBE1 mutation. Neuropathology and Applied Neurobiology. e12865. PMID 36456471 DOI: 10.1111/nan.12865  0.75
2022 Coughlin DG, Hiniker A, Peterson C, Kim Y, Arezoumandan S, Giannini L, Pizzo D, Weintraub D, Siderowf A, Litvan I, Rissman RA, Galasko D, Hansen L, Trojanowski JQ, Lee E, et al. Digital Histological Study of Neocortical Grey and White Matter Tau Burden Across Tauopathies. Journal of Neuropathology and Experimental Neurology. PMID 36269086 DOI: 10.1093/jnen/nlac094  0.734
2022 Nilsson J, Cousins KAQ, Gobom J, Portelius E, Chen-Plotkin A, Shaw LM, Grossman M, Irwin DJ, Trojanowski JQ, Zetterberg H, Blennow K, Brinkmalm A. Cerebrospinal fluid biomarker panel of synaptic dysfunction in Alzheimer's disease and other neurodegenerative disorders. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36239248 DOI: 10.1002/alz.12809  0.726
2022 Öhrfelt A, Benedet AL, Ashton NJ, Kvartsberg H, Vandijck M, Weiner MW, Trojanowski JQ, Shaw LM, Zetterberg H, Blennow K. Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive Individuals. Neurology. PMID 36192174 DOI: 10.1212/WNL.0000000000201417  0.307
2022 Kim B, Suh E, Nguyen AT, Prokop S, Mikytuck B, Olatunji OA, Robinson JL, Grossman M, Phillips JS, Irwin DJ, Mechanic-Hamilton D, Wolk DA, Trojanowski JQ, McMillan CT, Van Deerlin VM, et al. TREM2 risk variants are associated with atypical Alzheimer's disease. Acta Neuropathologica. PMID 36112222 DOI: 10.1007/s00401-022-02495-4  0.823
2022 Giannini LAA, Ohm DT, Rozemuller AJM, Dratch L, Suh E, van Deerlin VM, Trojanowski JQ, Lee EB, van Swieten JC, Grossman M, Seelaar H, Irwin DJ. Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta Neuropathologica. PMID 36066634 DOI: 10.1007/s00401-022-02487-4  0.794
2022 Quilico Cousins KA, Arezoumandan S, Shellikeri S, Ohm D, Shaw LM, Grossman M, Wolk D, McMillan CT, Chen-Plotkin A, Lee E, Trojanowski JQ, Zetterberg H, Blennow K, Irwin DJ. CSF Biomarkers of Alzheimer Disease in Patients With Concomitant α-Synuclein Pathology. Neurology. PMID 36041863 DOI: 10.1212/WNL.0000000000201202  0.823
2022 Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, ... ... Trojanowski JQ, et al. Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35997131 DOI: 10.1002/mds.29164  0.733
2022 Shellikeri S, Cho S, Cousins KAQ, Liberman M, Howard E, Balganorth Y, Weintraub D, Spindler M, Deik A, Lee EB, Trojanowski JQ, Irwin D, Wolk D, Grossman M, Nevler N. Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias. Parkinsonism & Related Disorders. 102: 94-100. PMID 35985146 DOI: 10.1016/j.parkreldis.2022.07.023  0.748
2022 Cousins KAQ, Shaw LM, Shellikeri S, Dratch L, Rosario L, Elman LB, Quinn C, Amado DA, Wolk DA, Tropea TF, Chen-Plotkin A, Irwin DJ, Grossman M, Lee EB, Trojanowski JQ, et al. Elevated plasma phosphorylated tau 181 in amyotrophic lateral sclerosis. Annals of Neurology. PMID 35877814 DOI: 10.1002/ana.26462  0.818
2022 Arezoumandan S, Xie SX, Cousins KAQ, Mechanic-Hamilton DJ, Peterson CS, Huang CY, Ohm DT, Ittyerah R, McMillan CT, Wolk DA, Yushkevich P, Trojanowski JQ, Lee EB, Grossman M, Phillips JS, et al. Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta Neuropathologica. PMID 35871112 DOI: 10.1007/s00401-022-02472-x  0.829
2022 Weintraub D, Posavi M, Fontanillas P, Tropea TF, Mamikonyan E, Suh E, Trojanowski JQ, Cannon P, Van Deerlin VM, Chen-Plotkin AS. Genetic prediction of impulse control disorders in Parkinson's disease. Annals of Clinical and Translational Neurology. PMID 35762106 DOI: 10.1002/acn3.51569  0.538
2022 Walker IM, Cousins KA, Siderowf A, Duda JE, Morley JF, Dahodwala N, Tropea T, Vaishnavi S, Wolk DA, Chen-Plotkin AS, Shaw LM, Lee EB, Trojanowski JQ, Grossman M, Weintraub D, et al. Non-tremor motor dysfunction in Lewy body dementias is associated with AD biomarkers. Parkinsonism & Related Disorders. 100: 33-36. PMID 35700626 DOI: 10.1016/j.parkreldis.2022.05.022  0.8
2022 Blömeke L, Pils M, Kraemer-Schulien V, Dybala A, Schaffrath A, Kulawik A, Rehn F, Cousin A, Nischwitz V, Willbold J, Zack R, Tropea TF, Bujnicki T, Tamgüney G, Weintraub D, ... ... Trojanowski JQ, et al. Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting. Npj Parkinson's Disease. 8: 68. PMID 35655068 DOI: 10.1038/s41531-022-00330-x  0.755
2022 Shen J, Amari N, Zack R, Skrinak RT, Unger TL, Posavi M, Tropea TF, Xie SX, Van Deerlin VM, Dewey RB, Weintraub D, Trojanowski JQ, Chen-Plotkin AS. Plasma MIA, CRP, and albumin predict cognitive decline in Parkinson's Disease. Annals of Neurology. PMID 35593028 DOI: 10.1002/ana.26410  0.52
2022 Coughlin DG, Coslett HB, Peterson C, Phillips JS, McMillan C, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. Lateralized and pathology in a case of Lewy body disease with corticobasal syndrome. Alzheimer's & Dementia (New York, N. Y.). 8: e12294. PMID 35592691 DOI: 10.1002/trc2.12294  0.804
2022 Morris JC, Weiner M, Xiong C, Beckett L, Coble D, Saito N, Aisen PS, Allegri R, Benzinger TLS, Berman SB, Cairns NJ, Carrillo MC, Chui HC, Chhatwal JP, Cruchaga C, ... ... Trojanowski JQ, et al. Autosomal dominant and sporadic late onset Alzheimer disease share a common in vivo pathophysiology. Brain : a Journal of Neurology. PMID 35580594 DOI: 10.1093/brain/awac181  0.383
2022 Hur SK, Hunter M, Dominique MA, Farag M, Cotton-Samuel D, Khan T, Trojanowski JQ, Spiller KJ, Lee VM. Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 10: 75. PMID 35568882 DOI: 10.1186/s40478-022-01373-0  0.378
2022 Cervantes González A, Irwin DJ, Alcolea D, McMillan CT, Chen-Plotkin A, Wolk D, Sirisi S, Dols-Icardo O, Querol-Vilaseca M, Illán-Gala I, Santos-Santos MA, Fortea J, Lee EB, Trojanowski JQ, Grossman M, et al. Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration. Molecular Neurodegeneration. 17: 29. PMID 35395770 DOI: 10.1186/s13024-022-00534-y  0.798
2022 Burke SE, Phillips JS, Olm CA, Peterson CS, Cook PA, Gee JC, Lee EB, Trojanowski JQ, Massimo L, Irwin DJ, Grossman M. Phases of volume loss in patients with known frontotemporal lobar degeneration spectrum pathology. Neurobiology of Aging. 113: 95-107. PMID 35325815 DOI: 10.1016/j.neurobiolaging.2022.02.007  0.716
2022 Chen M, Ohm DT, Phillips JS, McMillan CT, Capp N, Peterson C, Xie E, Wolk DA, Trojanowski JQ, Lee EB, Gee J, Grossman M, Irwin DJ. Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35318284 DOI: 10.1523/JNEUROSCI.2061-21.2022  0.807
2022 Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, ... ... Trojanowski JQ, et al. Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nature Communications. 13: 1362. PMID 35292638 DOI: 10.1038/s41467-022-28896-3  0.808
2022 Feng T, Luan L, Katz II, Ullah M, Van Deerlin VM, Trojanowski JQ, Lee EB, Hu F. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta Neuropathologica Communications. 10: 33. PMID 35287730 DOI: 10.1186/s40478-022-01334-7  0.539
2022 Marshall CA, McBride JD, Changolkar L, Riddle DM, Trojanowski JQ, Lee VM. Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization. Acta Neuropathologica Communications. 10: 30. PMID 35246269 DOI: 10.1186/s40478-022-01331-w  0.488
2022 Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, ... ... Trojanowski JQ, et al. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell. PMID 35063084 DOI: 10.1016/j.cell.2021.12.041  0.351
2022 Ohm DT, Cousins KAQ, Xie SX, Peterson C, McMillan CT, Massimo L, Raskovsky K, Wolk DA, Van Deerlin VM, Elman L, Spindler M, Deik A, Trojanowski JQ, Lee EB, Grossman M, et al. Signature laminar distributions of pathology in frontotemporal lobar degeneration. Acta Neuropathologica. PMID 34997851 DOI: 10.1007/s00401-021-02402-3  0.804
2021 Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain : a Journal of Neurology. PMID 35258081 DOI: 10.1093/brain/awab373  0.735
2021 Tisdall MD, Ohm DT, Lobrovich R, Das SR, Mizsei G, Prabhakaran K, Ittyerah R, Lim S, McMillan CT, Wolk DA, Gee J, Trojanowski JQ, Lee EB, Detre JA, Yushkevich P, et al. Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology. Neuroimage. Clinical. 33: 102913. PMID 34952351 DOI: 10.1016/j.nicl.2021.102913  0.815
2021 Uemura MT, Robinson JL, Cousins KAQ, Tropea TF, Kargilis DC, McBride JD, Suh E, Xie SX, Xu Y, Porta S, Uemura N, Van Deerlin VM, Wolk DA, Irwin DJ, Brunden KR, ... ... Trojanowski JQ, et al. Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease. Acta Neuropathologica. PMID 34854996 DOI: 10.1007/s00401-021-02383-3  0.73
2021 Marotta NP, Ara J, Uemura N, Lougee MG, Meymand ES, Zhang B, Petersson EJ, Trojanowski JQ, Lee VM. Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro. Acta Neuropathologica Communications. 9: 188. PMID 34819159 DOI: 10.1186/s40478-021-01288-2  0.443
2021 Kim BJ, Lee V, Lee EB, Saludades A, Trojanowski JQ, Dunaief JL, Grossman M, Irwin DJ. Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau. Acta Neuropathologica Communications. 9: 184. PMID 34794500 DOI: 10.1186/s40478-021-01290-8  0.702
2021 Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, ... ... Trojanowski JQ, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. PMID 34719765 DOI: 10.1007/s00401-021-02379-z  0.8
2021 Ravikumar S, Wisse LEM, Lim S, Ittyerah R, Xie L, Bedard ML, Das SR, Lee EB, Tisdall MD, Prabhakaran K, Lane J, Detre JA, Mizsei G, Trojanowski JQ, Robinson JL, et al. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta Neuropathologica Communications. 9: 173. PMID 34689831 DOI: 10.1186/s40478-021-01275-7  0.764
2021 Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR, Jagust WJ, Petersen RC, Saykin AJ, Shaw LM, Trojanowski JQ, Weiner MW. Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34647694 DOI: 10.1002/alz.12480  0.347
2021 Veitch DP, Weiner MW, Aisen PS, Beckett LA, DeCarli C, Green RC, Harvey D, Jack CR, Jagust W, Landau SM, Morris JC, Okonkwo O, Perrin RJ, Petersen RC, Rivera-Mindt M, ... ... Trojanowski JQ, et al. Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34581485 DOI: 10.1002/alz.12422  0.302
2021 Delizannis AT, Nonneman A, Tsering W, De Bondt A, Van den Wyngaert I, Zhang B, Meymand E, Olufemi MF, Koivula P, Maimaiti S, Trojanowski JQ, Lee VM, Brunden KR. Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice. Acta Neuropathologica Communications. 9: 150. PMID 34503586 DOI: 10.1186/s40478-021-01251-1  0.49
2021 Aamodt WW, Waligorska T, Shen J, Tropea TF, Siderowf A, Weintraub D, Grossman M, Irwin D, Wolk DA, Xie SX, Trojanowski JQ, Shaw LM, Chen-Plotkin AS. Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 34480363 DOI: 10.1002/mds.28779  0.685
2021 Hass EW, Sorrentino ZA, Xia Y, Lloyd GM, Trojanowski JQ, Prokop S, Giasson BI. Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies. Acta Neuropathologica Communications. 9: 146. PMID 34454615 DOI: 10.1186/s40478-021-01242-2  0.821
2021 Hunter M, Spiller KJ, Dominique MA, Xu H, Hunter FW, Fang TC, Canter RG, Roberts CJ, Ransohoff RM, Trojanowski JQ, Lee VM. Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery. Acta Neuropathologica Communications. 9: 140. PMID 34412701 DOI: 10.1186/s40478-021-01239-x  0.439
2021 Cousins KAQ, Bove J, Giannini LAA, Kinney NG, Balgenorth YR, Rascovsky K, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. Longitudinal naming and repetition relates to AD pathology and burden in autopsy-confirmed primary progressive aphasia. Alzheimer's & Dementia (New York, N. Y.). 7: e12188. PMID 34368417 DOI: 10.1002/trc2.12188  0.743
2021 Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, ... ... Trojanowski JQ, et al. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta Neuropathologica Communications. 9: 134. PMID 34353357 DOI: 10.1186/s40478-021-01233-3  0.709
2021 Yushkevich PA, López MM, Martin MMIO, Ittyerah R, Lim S, Ravikumar S, Bedard ML, Pickup S, Liu W, Wang J, Hung LY, Lasserve J, Vergnet N, Xie L, Dong M, ... ... Trojanowski JQ, et al. Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe. Brain : a Journal of Neurology. PMID 34259858 DOI: 10.1093/brain/awab262  0.822
2021 Puentes LN, Lengyel-Zhand Z, Lee JY, Hsieh CJ, Schneider ME, Edwards KJ, Luk KC, Lee VM, Trojanowski JQ, Mach RH. Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples. Frontiers in Aging Neuroscience. 13: 704041. PMID 34220490 DOI: 10.3389/fnagi.2021.704041  0.403
2021 Mao F, Robinson JL, Unger T, Posavi M, Amado DA, Elman L, Grossman M, Wolk DA, Lee EB, Van Deerlin VM, Porta S, Lee VMY, Trojanowski JQ, Chen-Plotkin AS. TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy. Acta Neuropathologica. PMID 34152475 DOI: 10.1007/s00401-021-02330-2  0.81
2021 Cornblath EJ, Li HL, Changolkar L, Zhang B, Brown HJ, Gathagan RJ, Olufemi MF, Trojanowski JQ, Bassett DS, Lee VMY, Henderson MX. Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor. Science Advances. 7. PMID 34108219 DOI: 10.1126/sciadv.abg6677  0.358
2021 Porta S, Xu Y, Lehr T, Zhang B, Meymand E, Olufemi M, Stieber A, Lee EB, Trojanowski JQ, Lee VM. Distinct Brain-derived TDP-43 Strains from FTLD-TDP Subtypes Induce Diverse Morphological TDP-43 Aggregates and Spreading Patterns in vitro and in vivo. Neuropathology and Applied Neurobiology. PMID 33971027 DOI: 10.1111/nan.12732  0.622
2021 Kim B, Mikytuck B, Suh E, Gibbons GS, Van Deerlin VM, Vaishnavi SN, Spindler MA, Massimo L, Grossman M, Trojanowski JQ, Irwin DJ, Lee EB. Tau immunotherapy is associated with glial responses in FTLD-tau. Acta Neuropathologica. PMID 33950293 DOI: 10.1007/s00401-021-02318-y  0.743
2021 Zhang JV, Irwin DJ, Blennow K, Zetterberg H, Lee EB, Shaw LM, Rascovsky K, Massimo L, McMillan CT, Chen-Plotkin A, Elman L, Lee VM, McCluskey L, Toledo JB, Weintraub D, ... ... Trojanowski JQ, et al. Neurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration. Neurology. Clinical Practice. 11: 105-116. PMID 33842063 DOI: 10.1212/CPJ.0000000000000959  0.797
2021 Soares AC, Ferreira A, Mariën J, Delay C, Lee E, Trojanowski JQ, Moechars D, Annaert W, De Muynck L. PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding. The Journal of Biological Chemistry. 100636. PMID 33831417 DOI: 10.1016/j.jbc.2021.100636  0.621
2021 Smith DH, Dollé JP, Ameen-Ali KE, Bretzin A, Cortes E, Crary JF, Dams-O'Connor K, Diaz-Arrastia R, Edlow BL, Folkerth R, Hazrati LN, Hinds SR, Iacono D, Johnson VE, Keene CD, ... ... Trojanowski JQ, et al. COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI). Acta Neuropathologica Communications. 9: 32. PMID 33648593 DOI: 10.1186/s40478-021-01122-9  0.524
2021 Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VM, Saito T, ... ... Trojanowski JQ, et al. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain Communications. 3: fcab011. PMID 33644757 DOI: 10.1093/braincomms/fcab011  0.531
2021 Giannini LAA, Peterson C, Ohm D, Xie SX, McMillan CT, Raskovsky K, Massimo L, Suh E, Van Deerlin VM, Wolk DA, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ. Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology. Acta Neuropathologica Communications. 9: 30. PMID 33622418 DOI: 10.1186/s40478-021-01129-2  0.824
2021 Howard E, Irwin DJ, Rascovsky K, Nevler N, Shellikeri S, Tropea TF, Spindler M, Deik A, Chen-Plotkin A, Siderowf A, Dahodwala N, Weintraub D, Shaw LM, Trojanowski JQ, Vaishnavi SN, et al. Cognitive Profile and Markers of AD-Type Pathology in Patients with Lewy Body Dementias. Neurology. PMID 33593865 DOI: 10.1212/WNL.0000000000011699  0.737
2021 Valentino RR, Heckman MG, Johnson PW, Baker MC, Soto-Beasley AI, Walton RL, Koga S, Roemer SF, Suh E, Uitti RJ, Trojanowski JQ, Grossman M, Van Deerlin VM, Rademakers R, Wszolek ZK, et al. Association of Mitochondrial DNA Genomic Variation with Risk of Pick's disease. Neurology. PMID 33568542 DOI: 10.1212/WNL.0000000000011649  0.395
2021 Coughlin DG, Grossman M, Trojanowski JQ, Irwin DJ. Hippocampal Subfield Pathologic Burden in Lewy Body Diseases versus Alzheimer's Disease. Neuropathology and Applied Neurobiology. PMID 33492664 DOI: 10.1111/nan.12698  0.663
2021 Oukoloff K, Nzou G, Varricchio C, Lucero B, Alle T, Kovalevich J, Monti L, Cornec AS, Yao Y, James MJ, Trojanowski JQ, Lee VM, Smith AB, Brancale A, Brunden KR, et al. Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies. Journal of Medicinal Chemistry. PMID 33411523 DOI: 10.1021/acs.jmedchem.0c01605  0.433
2021 Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G, Hortobagyi T, Jellinger K, Kovacs GG, Lee EB, Love S, McAleese KE, Nelson PT, Neumann M, Parkkinen L, ... ... Trojanowski JQ, et al. Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study. Acta Neuropathologica. PMID 33399945 DOI: 10.1007/s00401-020-02255-2  0.68
2021 Xu H, O'Reilly M, Gibbons GS, Changolkar L, McBride JD, Riddle DM, Zhang B, Stieber A, Nirschl J, Kim SJ, Hoxha KH, Brunden KR, Schellenberg GD, Trojanowski JQ, Lee VM. In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics. Acta Neuropathologica. PMID 33385254 DOI: 10.1007/s00401-020-02253-4  0.791
2021 Bassil F, Meymand ES, Brown HJ, Xu H, Cox TO, Pattabhiraman S, Maghames CM, Wu Q, Zhang B, Trojanowski JQ, Lee VM. α-Synuclein modulates tau spreading in mouse brains. The Journal of Experimental Medicine. 218. PMID 33091110 DOI: 10.1084/jem.20192193  0.506
2020 Robinson JL, Richardson H, Xie SX, Suh E, Van Deerlin VM, Alfaro B, Loh N, Porras-Paniagua M, Nirschl JJ, Wolk D, Lee VM, Lee EB, Trojanowski JQ. The development and convergence of co-pathologies in Alzheimer's disease. Brain : a Journal of Neurology. PMID 33449993 DOI: 10.1093/brain/awaa438  0.822
2020 Arena JD, Johnson VE, Lee EB, Gibbons GS, Smith DH, Trojanowski JQ, Stewart W. Astroglial tau pathology alone preferentially concentrates at sulcal depths in chronic traumatic encephalopathy neuropathologic change. Brain Communications. 2: fcaa210. PMID 33426528 DOI: 10.1093/braincomms/fcaa210  0.582
2020 Gallagher J, Rick J, Xie SX, Martinez-Martin P, Mamikonyan E, Chen-Plotkin A, Dahodwala N, Morley J, Duda JE, Trojanowski JQ, Siderowf A, Weintraub D. Psychometric Properties of the Clinical Dementia Rating Scale Sum of Boxes in Parkinson's Disease. Journal of Parkinson's Disease. PMID 33386814 DOI: 10.3233/JPD-202390  0.567
2020 Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, ... ... Trojanowski JQ, et al. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. Journal of Neuropathology and Experimental Neurology. PMID 33367843 DOI: 10.1093/jnen/nlaa153  0.799
2020 Placek K, Benatar M, Wuu J, Rampersaud E, Hennessy L, Van Deerlin VM, Grossman M, Irwin DJ, Elman L, McCluskey L, Quinn C, Granit V, Statland JM, Burns TM, Ravits J, ... ... Trojanowski JQ, et al. Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis. Embo Molecular Medicine. e12595. PMID 33270986 DOI: 10.15252/emmm.202012595  0.749
2020 Cousins KAQ, Phillips JS, Irwin DJ, Lee EB, Wolk DA, Shaw LM, Zetterberg H, Blennow K, Burke SE, Kinney NG, Gibbons GS, McMillan CT, Trojanowski JQ, Grossman M. ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33226735 DOI: 10.1002/alz.12233  0.791
2020 Gibbons GS, Kim SJ, Wu Q, Riddle DM, Leight SN, Changolkar L, Xu H, Meymand ES, O'Reilly M, Zhang B, Brunden KR, Trojanowski JQ, Lee VMY. Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 15: 64. PMID 33148293 DOI: 10.1186/s13024-020-00404-5  0.34
2020 Trzeciakiewicz H, Ajit D, Tseng JH, Chen Y, Ajit A, Tabassum Z, Lobrovich R, Peterson C, Riddick NV, Itano MS, Tripathy A, Moy SS, Lee VMY, Trojanowski JQ, Irwin DJ, et al. An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline. Nature Communications. 11: 5522. PMID 33139698 DOI: 10.1038/s41467-020-19317-4  0.582
2020 Tagai K, Ono M, Kubota M, Kitamura S, Takahata K, Seki C, Takado Y, Shinotoh H, Sano Y, Yamamoto Y, Matsuoka K, Takuwa H, Shimojo M, Takahashi M, Kawamura K, ... ... Trojanowski JQ, et al. High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies. Neuron. PMID 33125873 DOI: 10.1016/j.neuron.2020.09.042  0.319
2020 Spotorno N, Coughlin DG, Olm CA, Wolk D, Vaishnavi SN, Shaw LM, Dahodwala N, Morley JF, Duda JE, Deik AF, Spindler MA, Chen-Plotkin A, Lee EB, Trojanowski JQ, McMillan CT, et al. Tau pathology associates with in vivo cortical thinning in Lewy body disorders. Annals of Clinical and Translational Neurology. PMID 33108692 DOI: 10.1002/acn3.51183  0.821
2020 Karikari TK, Benedet AL, Ashton NJ, Lantero Rodriguez J, Snellman A, Suárez-Calvet M, Saha-Chaudhuri P, Lussier F, Kvartsberg H, Rial AM, Pascoal TA, Andreasson U, Schöll M, Weiner MW, Rosa-Neto P, ... Trojanowski JQ, et al. Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative. Molecular Psychiatry. PMID 33106600 DOI: 10.1038/s41380-020-00923-z  0.344
2020 Franzmeier N, Suárez-Calvet M, Frontzkowski L, Moore A, Hohman TJ, Morenas-Rodriguez E, Nuscher B, Shaw L, Trojanowski JQ, Dichgans M, Kleinberger G, Haass C, Ewers M. Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration. Molecular Neurodegeneration. 15: 57. PMID 33032659 DOI: 10.1186/s13024-020-00407-2  0.497
2020 Wu Q, Shaikh MA, Meymand ES, Zhang B, Luk KC, Trojanowski JQ, Lee VM. Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta Neuropathologica. PMID 33021680 DOI: 10.1007/s00401-020-02227-6  0.396
2020 Coughlin DG, Phillips JS, Roll E, Peterson C, Lobrovich R, Rascovsky K, Ungrady M, Wolk DA, Das S, Weintraub D, Lee EB, Trojanowski JQ, Shaw LM, Vaishnavi S, Siderowf A, et al. Multimodal in vivo and postmortem assessments of tau in Lewy body disorders. Neurobiology of Aging. 96: 137-147. PMID 33002767 DOI: 10.1016/J.Neurobiolaging.2020.08.003  0.783
2020 Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, ... ... Trojanowski JQ, et al. Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. Journal of Neuropathology and Experimental Neurology. PMID 33000167 DOI: 10.1093/jnen/nlaa109  0.553
2020 Sopko R, Golonzhka O, Arndt J, Quan C, Czerkowicz J, Cameron A, Smith B, Murugesan Y, Gibbons G, Kim SJ, Trojanowski JQ, Lee VMY, Brunden KR, Weinreb PH, Graham DL, et al. Characterization of tau binding by gosuranemab. Neurobiology of Disease. 105120. PMID 32991997 DOI: 10.1016/j.nbd.2020.105120  0.371
2020 Costa B, Manzoni C, Bernal-Quiros M, Kia DA, Aguilar M, Alvarez I, Alvarez V, Andreassen O, Anfossi M, Bagnoli S, Benussi L, Bernardi L, Binetti G, Blackburn D, Boada M, ... ... Trojanowski JQ, et al. , AAO and ancestry help discriminating behavioural from language variants in FTLD cohorts. Neurology. PMID 32943482 DOI: 10.1212/Wnl.0000000000010914  0.427
2020 Yao Y, Nzou G, Alle T, Tsering W, Maimaiti S, Trojanowski JQ, Lee VM, Ballatore C, Brunden KR. Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32918367 DOI: 10.1002/Alz.12144  0.564
2020 Van Kolen K, Malia TJ, Theunis C, Nanjunda R, Teplyakov A, Ernst R, Wu SJ, Luo J, Borgers M, Vandermeeren M, Bottelbergs A, Wintmolders C, Lacy E, Maurin H, Larsen P, ... ... Trojanowski JQ, et al. Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody. Journal of Alzheimer's Disease : Jad. PMID 32894244 DOI: 10.3233/Jad-200544  0.443
2020 Coughlin DG, Ittyerah R, Peterson C, Phillips JS, Miller S, Rascovsky K, Weintraub DA, Siderowf AD, Duda JE, Hurtig HI, Wolk DA, McMillan C, Yushkevich PA, Grossman M, Lee EB, ... Trojanowski JQ, et al. Hippocampal Subfield Pathologic Burden in Lewy Body Diseases versus Alzheimer's Disease. Neuropathology and Applied Neurobiology. PMID 32892355 DOI: 10.1111/Nan.12659  0.783
2020 Weitzman SA, Narasimhan S, He Z, Changolkar L, McBride JD, Zhang B, Schellenberg GD, Trojanowski JQ, Lee VMY. Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo. Journal of Neuropathology and Experimental Neurology. 79: 941-949. PMID 32838419 DOI: 10.1093/Jnen/Nlaa086  0.466
2020 Robinson JL, Porta S, Garrett FG, Zhang P, Xie SX, Suh E, Van Deerlin VM, Abner EL, Jicha GA, Barber JM, Lee VM, Lee EB, Trojanowski JQ, Nelson PT. Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration. Brain : a Journal of Neurology. PMID 32830216 DOI: 10.1093/Brain/Awaa219  0.765
2020 Ohm DT, Peterson C, Lobrovich R, Cousins KAQ, Gibbons GS, McMillan CT, Wolk DA, Van Deerlin V, Elman L, Spindler M, Deik A, Siderowf A, Trojanowski JQ, Lee EB, Grossman M, et al. Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum. Acta Neuropathologica. PMID 32804255 DOI: 10.1007/S00401-020-02210-1  0.83
2020 Guo T, Korman D, La Joie R, Shaw LM, Trojanowski JQ, Jagust WJ, Landau SM. Normalization of CSF pTau measurement by Aβ improves its performance as a biomarker of Alzheimer's disease. Alzheimer's Research & Therapy. 12: 97. PMID 32799929 DOI: 10.1186/S13195-020-00665-8  0.458
2020 Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M, et al. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. Embo Molecular Medicine. e12308. PMID 32790063 DOI: 10.15252/Emmm.202012308  0.55
2020 Guo T, Shaw LM, Trojanowski JQ, Jagust WJ, Landau SM. Association of CSF Aβ, amyloid PET and cognition in cognitively unimpaired elderly adults. Neurology. PMID 32759202 DOI: 10.1212/Wnl.0000000000010596  0.305
2020 Dai DL, Tropea TF, Robinson JL, Suh E, Hurtig H, Weintraub D, Van Deerlin V, Lee EB, Trojanowski JQ, Chen-Plotkin AS. ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies. Acta Neuropathologica. PMID 32749525 DOI: 10.1007/S00401-020-02199-7  0.751
2020 Cornblath EJ, Robinson JL, Irwin DJ, Lee EB, Lee VM, Trojanowski JQ, Bassett DS. Defining and predicting transdiagnostic categories of neurodegenerative disease. Nature Biomedical Engineering. PMID 32747831 DOI: 10.1038/S41551-020-0593-Y  0.746
2020 Gryc W, Roberts KA, Zabetian CP, Weintraub D, Trojanowski JQ, Quinn JF, Hiller AL, Chung KA, Poston KL, Yang L, Hu SC, Edwards KL, Montine TJ, Cholerton BA. Hallucinations and Development of Dementia in Parkinson's Disease. Journal of Parkinson's Disease. PMID 32741842 DOI: 10.3233/Jpd-202116  0.347
2020 Kling MA, Goodenowe DB, Senanayake V, MahmoudianDehkordi S, Arnold M, Massaro TJ, Baillie R, Han X, Leung YY, Saykin AJ, Nho K, Kueider-Paisley A, Tenenbaum JD, Wang LS, Shaw LM, ... Trojanowski JQ, et al. Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32715599 DOI: 10.1002/Alz.12110  0.435
2020 Cousins KAQ, Irwin DJ, Wolk DA, Lee EB, Shaw LMJ, Trojanowski JQ, Da Re F, Gibbons GS, Grossman M, Phillips JS. ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration. Brain : a Journal of Neurology. PMID 32666090 DOI: 10.1093/Brain/Awaa165  0.778
2020 Kovacs GG, Robinson JL, Perl DP, Lee VM, Trojanowski JQ. Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex. Acta Neuropathologica. PMID 32662040 DOI: 10.1007/S00401-020-02192-0  0.484
2020 Gentry MT, Lapid MI, Syrjanen J, Calvert K, Hughes S, Brushaber D, Kremers W, Bove J, Brannelly P, Coppola G, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, ... ... Trojanowski J, et al. Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32656921 DOI: 10.1002/Alz.12095  0.584
2020 Riad A, Lengyel-Zhand Z, Zeng C, Weng CC, Lee VM, Trojanowski JQ, Mach RH. The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates. Molecular Neurobiology. PMID 32572762 DOI: 10.1007/S12035-020-01988-1  0.499
2020 Irwin DJ, Felder J, Coffey CS, Caspell-Garcia C, Kang JH, Simuni T, Foroud T, Toga AW, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten S, Weintraub D, Mollenhauer B, ... ... Trojanowski JQ, et al. Evolution of Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Early Parkinson's Disease. Annals of Neurology. PMID 32542885 DOI: 10.1002/Ana.25811  0.593
2020 Purri R, Brennan L, Rick J, Xie SX, Deck BL, Chahine LM, Dahodwala N, Chen-Plotkin A, Duda JE, Morley JF, Akhtar RS, Trojanowski JQ, Siderowf A, Weintraub D. Subjective Cognitive Complaint in Parkinson's Disease Patients with Normal Cognition: Canary in the Coal Mine? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32520435 DOI: 10.1002/Mds.28115  0.58
2020 Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL, Lee VM, Trojanowski JQ, Stewart W, Johnson VE. Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease. Brain : a Journal of Neurology. PMID 32390044 DOI: 10.1093/Brain/Awaa071  0.771
2020 Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, ... ... Trojanowski JQ, et al. Distribution patterns of tau pathology in progressive supranuclear palsy. Acta Neuropathologica. PMID 32383020 DOI: 10.1007/S00401-020-02158-2  0.818
2020 Uemura N, Uemura MT, Luk KC, Lee VM, Trojanowski JQ. Cell-to-Cell Transmission of Tau and α-Synuclein. Trends in Molecular Medicine. PMID 32371172 DOI: 10.1016/J.Molmed.2020.03.012  0.546
2020 Bernath MM, Bhattacharyya S, Nho K, Barupal DK, Fiehn O, Baillie R, Risacher SL, Arnold M, Jacobson T, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R, Saykin AJ, et al. Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers. Neurology. PMID 32358220 DOI: 10.1212/Wnl.0000000000009436  0.453
2020 de Flores R, Wisse LEM, Das SR, Xie L, McMillan CT, Trojanowski JQ, Robinson JL, Grossman M, Lee E, Irwin DJ, Yushkevich PA, Wolk DA. Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32323446 DOI: 10.1002/Alz.12079  0.806
2020 Uemura MT, Maki T, Ihara M, Lee VMY, Trojanowski JQ. Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia. Frontiers in Aging Neuroscience. 12: 80. PMID 32317958 DOI: 10.3389/Fnagi.2020.00080  0.389
2020 Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, et al. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature Medicine. PMID 32284590 DOI: 10.1038/S41591-020-0815-6  0.647
2020 Takeuchi H, Imamura K, Ji B, Tsukita K, Enami T, Takao K, Miyakawa T, Hasegawa M, Sahara N, Iwata N, Inoue M, Hara H, Tabira T, Ono M, Trojanowski JQ, et al. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. Npj Vaccines. 5: 28. PMID 32219000 DOI: 10.1038/s41541-020-0172-y  0.469
2020 Peng C, Trojanowski JQ, Lee VM. Protein transmission in neurodegenerative disease. Nature Reviews. Neurology. PMID 32203399 DOI: 10.1038/S41582-020-0333-7  0.562
2020 Arnold M, Nho K, Kueider-Paisley A, Massaro T, Huynh K, Brauner B, MahmoudianDehkordi S, Louie G, Moseley MA, Thompson JW, John-Williams LS, Tenenbaum JD, Blach C, Chang R, Brinton RD, ... ... Trojanowski JQ, et al. Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome. Nature Communications. 11: 1148. PMID 32123170 DOI: 10.1038/S41467-020-14959-W  0.359
2020 Lengyel-Zhand Z, Ferrie JJ, Janssen B, Hsieh CJ, Graham T, Xu KY, Haney CM, Lee VM, Trojanowski JQ, Petersson EJ, Mach RH. Synthesis and characterization of high affinity fluorogenic α-synuclein probes. Chemical Communications (Cambridge, England). PMID 32104795 DOI: 10.1039/C9Cc09849F  0.444
2020 Korecka M, Figurski MJ, Landau SM, Brylska M, Alexander J, Blennow K, Zetterberg H, Jagust WJ, Trojanowski JQ, Shaw LM. Analytical and Clinical Performance of Amyloid-Beta Peptides Measurements in CSF of ADNIGO/2 Participants by an LC-MS/MS Reference Method. Clinical Chemistry. PMID 32087019 DOI: 10.1093/Clinchem/Hvaa012  0.371
2020 Simuni T, Brumm MC, Uribe L, Caspell-Garcia C, Coffey CS, Siderowf A, Alcalay R, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Nudelman K, et al. Clinical and Dopamine Transporter Imaging Characteristics of Leucine- Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32073681 DOI: 10.1002/Mds.27989  0.322
2020 Crowe A, Henderson MJ, Anderson J, Titus SA, Zakharov A, Simeonov A, Buist A, Delay C, Moechars D, Trojanowski JQ, Lee VMY, Brunden KR. Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays. The Journal of Biological Chemistry. PMID 32034092 DOI: 10.1074/Jbc.Ra119.010532  0.438
2020 Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, ... ... Trojanowski JQ, et al. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications. 11: 667. PMID 32015339 DOI: 10.1038/S41467-019-14279-8  0.435
2020 Orme T, Hernandez D, Ross OA, Kun-Rodrigues C, Darwent L, Shepherd CE, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, ... ... Trojanowski JQ, et al. Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies. Acta Neuropathologica Communications. 8: 5. PMID 31996268 DOI: 10.1186/S40478-020-0879-Z  0.441
2020 Roy ER, Wang B, Wan YW, Chiu GS, Cole AL, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, et al. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. The Journal of Clinical Investigation. PMID 31917687 DOI: 10.1172/Jci133737  0.551
2020 Staffaroni AM, Bajorek L, Casaletto KB, Cobigo Y, Goh SM, Wolf A, Heuer HW, Elahi FM, Ljubenkov PA, Dever R, Kornak J, Appleby B, Bove J, Bordelon Y, Brannelly P, ... ... Trojanowski JQ, et al. Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 11-21. PMID 31914230 DOI: 10.1016/J.Jalz.2019.01.012  0.72
2020 Miyagawa T, Brushaber D, Syrjanen J, Kremers W, Fields J, Forsberg LK, Heuer HW, Knopman D, Kornak J, Boxer A, Rosen HJ, Boeve BF, Appleby B, Bordelon Y, Bove J, ... ... Trojanowski JQ, et al. Utility of the global CDR plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 106-117. PMID 31914218 DOI: 10.1002/Alz.12033  0.68
2020 Ramos EM, Dokuru DR, Van Berlo V, Wojta K, Wang Q, Huang AY, Deverasetty S, Qin Y, van Blitterswijk M, Jackson J, Appleby B, Bordelon Y, Brannelly P, Brushaber DE, Dickerson B, ... ... Trojanowski JQ, et al. Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 118-130. PMID 31914217 DOI: 10.1002/Alz.12011  0.709
2020 He Z, McBride JD, Xu H, Changolkar L, Kim SJ, Zhang B, Narasimhan S, Gibbons GS, Guo JL, Kozak M, Schellenberg GD, Trojanowski JQ, Lee VM. Transmission of tauopathy strains is independent of their isoform composition. Nature Communications. 11: 7. PMID 31911587 DOI: 10.1038/S41467-019-13787-X  0.514
2020 Narasimhan S, Changolkar L, Riddle DM, Kats A, Stieber A, Weitzman SA, Zhang B, Li Z, Roberson ED, Trojanowski JQ, Lee VMY. Human tau pathology transmits glial tau aggregates in the absence of neuronal tau. The Journal of Experimental Medicine. 217. PMID 31826239 DOI: 10.1084/Jem.20190783  0.439
2019 Robinson JL, Yan N, Caswell C, Xie SX, Suh E, Van Deerlin VM, Gibbons G, Irwin DJ, Grossman M, Lee EB, Lee VM, Miller B, Trojanowski JQ. Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD. Journal of Neuropathology and Experimental Neurology. PMID 31999351 DOI: 10.1093/Jnen/Nlz141  0.797
2019 Henderson MX, Sedor S, McGeary I, Cornblath EJ, Peng C, Riddle DM, Li HL, Zhang B, Brown HJ, Olufemi MF, Bassett DS, Trojanowski JQ, Lee VMY. Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult. Neuron. PMID 31899072 DOI: 10.1016/J.Neuron.2019.12.004  0.353
2019 Kornak J, Fields J, Kremers W, Farmer S, Heuer HW, Forsberg L, Brushaber D, Rindels A, Dodge H, Weintraub S, Besser L, Appleby B, Bordelon Y, Bove J, Brannelly P, ... ... Trojanowski J, et al. Nonlinear Z-score modeling for improved detection of cognitive abnormality. Alzheimer's & Dementia (Amsterdam, Netherlands). 11: 797-808. PMID 31872042 DOI: 10.1016/J.Dadm.2019.08.003  0.568
2019 Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, et al. Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Science Translational Medicine. 11. PMID 31852801 DOI: 10.1126/Scitranslmed.Aao6545  0.463
2019 Shaw LM, Korecka M, Figurski M, Toledo J, Irwin D, Hee Kang J, Trojanowski JQ. Detection of Alzheimer Disease Pathology in Patients Using Biochemical Biomarkers: Prospects and Challenges for Use in Clinical Practice. The Journal of Applied Laboratory Medicine. PMID 31848218 DOI: 10.1373/jalm.2019.029587  0.575
2019 Henderson MX, Covell DJ, Chung CH, Pitkin RM, Sandler RM, Decker SC, Riddle DM, Zhang B, Gathagan RJ, James MJ, Trojanowski JQ, Brunden KR, Lee VMY, Luk KC. Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease. Neurobiology of Disease. 104712. PMID 31837422 DOI: 10.1016/J.Nbd.2019.104712  0.368
2019 Blennow K, Shaw LM, Stomrud E, Mattsson N, Toledo JB, Buck K, Wahl S, Eichenlaub U, Lifke V, Simon M, Trojanowski JQ, Hansson O. Predicting clinical decline and conversion to Alzheimer's disease or dementia using novel Elecsys Aβ(1-42), pTau and tTau CSF immunoassays. Scientific Reports. 9: 19024. PMID 31836810 DOI: 10.1038/S41598-019-54204-Z  0.415
2019 Olney NT, Ong E, Goh SM, Bajorek L, Dever R, Staffaroni AM, Cobigo Y, Bock M, Chiang K, Ljubenkov P, Kornak J, Heuer HW, Wang P, Rascovsky K, Wolf A, ... ... Trojanowski JQ, et al. Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31784375 DOI: 10.1016/J.Jalz.2019.08.196  0.705
2019 Bassil F, Brown HJ, Pattabhiraman S, Iwasyk JE, Maghames CM, Meymand ES, Cox TO, Riddle DM, Zhang B, Trojanowski JQ, Lee VM. Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology. Neuron. PMID 31759806 DOI: 10.1016/J.Neuron.2019.10.010  0.576
2019 Henderson MX, Sengupta M, Trojanowski JQ, Lee VMY. Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease. Acta Neuropathologica Communications. 7: 183. PMID 31733655 DOI: 10.1186/S40478-019-0836-X  0.428
2019 Prokop S, Lee VMY, Trojanowski JQ. Neuroimmune interactions in Alzheimer's disease-New frontier with old challenges? Progress in Molecular Biology and Translational Science. 168: 183-201. PMID 31699314 DOI: 10.1016/Bs.Pmbts.2019.10.002  0.671
2019 Simuni T, Uribe L, Cho HR, Caspell-Garcia C, Coffey CS, Siderowf A, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Tosun D, Poston K, et al. Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study. The Lancet. Neurology. PMID 31678032 DOI: 10.1016/S1474-4422(19)30319-9  0.365
2019 de Flores R, Berron D, Ding SL, Ittyerah R, Pluta JB, Xie L, Adler DH, Robinson JL, Schuck T, Trojanowski JQ, Grossman M, Liu W, Pickup S, Das SR, Wolk DA, et al. Characterization of hippocampal subfields using ex vivo MRI and histology data: Lessons for in vivo segmentation. Hippocampus. PMID 31675165 DOI: 10.1002/Hipo.23172  0.451
2019 Boeve B, Bove J, Brannelly P, Brushaber D, Coppola G, Dever R, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova R, ... ... Trojanowski J, et al. The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31636026 DOI: 10.1016/J.Jalz.2019.06.4947  0.594
2019 Spotorno N, Hall S, Irwin DJ, Rumetshofer T, Acosta-Cabronero J, Deik AF, Spindler MA, Lee EB, Trojanowski JQ, van Westen D, Nilsson M, Grossman M, Nestor PJ, McMillan CT, Hansson O. Diffusion Tensor MRI to Distinguish Progressive Supranuclear Palsy from α-Synucleinopathies. Radiology. 190406. PMID 31617796 DOI: 10.1148/Radiol.2019190406  0.749
2019 Posavi M, Diaz-Ortiz M, Liu B, Swanson CR, Skrinak RT, Hernandez-Con P, Amado DA, Fullard M, Rick J, Siderowf A, Weintraub D, McCluskey L, Trojanowski JQ, Dewey RB, Huang X, et al. Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis. Plos Medicine. 16: e1002931. PMID 31603904 DOI: 10.1371/Journal.Pmed.1002931  0.801
2019 Chen Q, Boeve BF, Schwarz CG, Reid R, Tosakulwong N, Lesnick TG, Bove J, Brannelly P, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fields J, ... ... Trojanowski J, et al. Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers. Neurobiology of Aging. 83: 54-62. PMID 31585367 DOI: 10.1016/J.Neurobiolaging.2019.08.011  0.606
2019 Chu Y, Muller S, Tavares A, Barret O, Alagille D, Seibyl J, Tamagnan G, Marek K, Luk KC, Trojanowski JQ, Lee VMY, Kordower JH. Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes. Brain : a Journal of Neurology. PMID 31580415 DOI: 10.1093/Brain/Awz296  0.368
2019 Caswell C, McMillan CT, Xie SX, Van Deerlin VM, Suh E, Lee EB, Trojanowski JQ, Lee VM, Irwin DJ, Grossman M, Massimo LM. Genetic predictors of survival in behavioral variant frontotemporal degeneration. Neurology. PMID 31537715 DOI: 10.1212/Wnl.0000000000008387  0.753
2019 Uemura N, Uemura MT, Lo A, Bassil F, Zhang B, Luk KC, Lee VM, Takahashi R, Trojanowski JQ. Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy. Journal of Neuropathology and Experimental Neurology. PMID 31504665 DOI: 10.1093/Jnen/Nlz070  0.478
2019 Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, ... ... Trojanowski JQ, et al. Sex differences in the genetic predictors of Alzheimer's pathology. Brain : a Journal of Neurology. 142: 2581-2589. PMID 31497858 DOI: 10.1093/Brain/Awz206  0.38
2019 Ewers M, Franzmeier N, Suárez-Calvet M, Morenas-Rodriguez E, Caballero MAA, Kleinberger G, Piccio L, Cruchaga C, Deming Y, Dichgans M, Trojanowski JQ, Shaw LM, Weiner MW, Haass C. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science Translational Medicine. 11. PMID 31462511 DOI: 10.1126/Scitranslmed.Aav6221  0.58
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Trojanowski JQ, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.715
2019 Deck BL, Xie SX, Choi G, Rick J, Siderowf A, Rudovsky S, Chen-Plotkin A, Duda JE, Morley JF, Dahodwala N, Trojanowski JQ, Weintraub D. Cognitive Functional Abilities in Parkinson's Disease: Agreement Between Patients and Informants. Movement Disorders Clinical Practice. 6: 440-445. PMID 31392244 DOI: 10.1002/Mdc3.12781  0.593
2019 Mollenhauer B, Caspell-Garcia CJ, Coffey CS, Taylor P, Singleton A, Shaw LM, Trojanowski JQ, Frasier M, Simuni T, Iranzo A, Oertel W, Siderowf A, Weintraub D, Seibyl J, Toga AW, et al. Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31361367 DOI: 10.1002/Mds.27806  0.318
2019 Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Fardo DW, Flanagan ME, Halliday G, Hunter S, et al. Reply: LATE to the PART-y. Brain : a Journal of Neurology. PMID 31359039 DOI: 10.1093/Brain/Awz226  0.54
2019 Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM, Trojanowski JQ. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta Neuropathologica. PMID 31350575 DOI: 10.1007/S00401-019-02048-2  0.823
2019 Henderson MX, Cornblath EJ, Darwich A, Zhang B, Brown H, Gathagan RJ, Sandler RM, Bassett DS, Trojanowski JQ, Lee VMY. Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis. Nature Neuroscience. 22: 1248-1257. PMID 31346295 DOI: 10.1038/S41593-019-0457-5  0.351
2019 Giannini LAA, Xie SX, Peterson C, Zhou C, Lee EB, Wolk DA, Grossman M, Trojanowski JQ, McMillan CT, Irwin DJ. Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration. Frontiers in Neuroscience. 13: 682. PMID 31333403 DOI: 10.3389/Fnins.2019.00682  0.762
2019 Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, ... ... Trojanowski JQ, et al. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. Acta Neuropathologica. PMID 31327044 DOI: 10.1007/S00401-019-02045-5  0.701
2019 Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC. Humanization of the entire murine gene provides a murine model of pathological human tau propagation. The Journal of Biological Chemistry. PMID 31273083 DOI: 10.1074/Jbc.Ra119.009487  0.43
2019 Staffaroni AM, Cobigo Y, Goh SM, Kornak J, Bajorek L, Chiang K, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dever R, Dheel C, ... ... Trojanowski JQ, et al. Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31272932 DOI: 10.1016/J.Jalz.2019.04.007  0.697
2019 Henderson MX, Trojanowski JQ, Lee VM. α-Synuclein Pathology in Parkinson's Disease and Related α-Synucleinopathies. Neuroscience Letters. 134316. PMID 31170426 DOI: 10.1016/J.Neulet.2019.134316  0.529
2019 Lee EB, Kinch K, Johnson VE, Trojanowski JQ, Smith DH, Stewart W. Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players. Acta Neuropathologica. PMID 31152201 DOI: 10.1007/S00401-019-02030-Y  0.654
2019 Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, et al. Erratum: Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. (Brain (2019) 142, (1503–1527) DOI: 10.1093/brain/awz099) Brain. 142. PMID 31147685 DOI: 10.1093/Brain/Awz163  0.586
2019 Phillips JS, Da Re F, Irwin DJ, McMillan CT, Vaishnavi SN, Xie SX, Lee EB, Cook PA, Gee JC, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer's disease. Brain : a Journal of Neurology. 142: 1701-1722. PMID 31135048 DOI: 10.1093/Brain/Awz091  0.805
2019 Toledo JB, Habes M, Sotiras A, Bjerke M, Fan Y, Weiner MW, Shaw LM, Davatzikos C, Trojanowski JQ. APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points. Journal of Alzheimer's Disease : Jad. PMID 31127775 DOI: 10.3233/Jad-181282  0.41
2019 Staffaroni AM, Bajorek L, Casaletto KB, Cobigo Y, Goh SM, Wolf A, Heuer HW, Elahi FM, Ljubenkov PA, Dever R, Kornak J, Appleby B, Bove J, Bordelon Y, Brannelly P, ... ... Trojanowski JQ, et al. Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31088775 DOI: 10.1016/j.jalz.2019.01.012  0.623
2019 Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain : a Journal of Neurology. PMID 31039256 DOI: 10.1093/Brain/Awz099  0.68
2019 Wu Q, Takano H, Riddle DM, Trojanowski JQ, Coulter DA, Lee VM. Alpha-synuclein (αSyn) preformed fibrils induce endogenous αSyn aggregation, compromise synaptic activity and enhance synapse loss in cultured excitatory hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31036761 DOI: 10.1523/Jneurosci.0060-19.2019  0.469
2019 Berson A, Goodman LD, Sartoris AN, Otte CG, Aykit JA, Lee VM, Trojanowski JQ, Bonini NM. Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies. Acta Neuropathologica Communications. 7: 65. PMID 31036086 DOI: 10.1186/S40478-019-0710-X  0.538
2019 Tropea TF, Mak J, Guo MH, Xie SX, Suh E, Rick J, Siderowf A, Weintraub D, Grossman M, Irwin D, Wolk DA, Trojanowski JQ, Van Deerlin V, Chen-Plotkin AS. TMEM106B Effect on Cognition in Parkinson's Disease and Frontotemporal Dementia. Annals of Neurology. PMID 30973966 DOI: 10.1002/Ana.25486  0.746
2019 Stewart T, Shi M, Mehrotra A, Aro P, Soltys D, Kerr KF, Zabetian CP, Peskind ER, Taylor P, Shaw LM, Trojanowski JQ, Zhang J. Impact of Pre-Analytical Differences on Biomarkers in the ADNI and PPMI Studies: Implications in the Era of Classifying Disease Based on Biomarkers. Journal of Alzheimer's Disease : Jad. PMID 30958379 DOI: 10.3233/Jad-190069  0.394
2019 Guerreiro R, Escott-Price V, Hernandez DG, Kun-Rodrigues C, Ross OA, Orme T, Neto JL, Carmona S, Dehghani N, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, ... ... Trojanowski JQ, et al. Heritability and genetic variance of dementia with Lewy bodies. Neurobiology of Disease. PMID 30953760 DOI: 10.1016/J.Nbd.2019.04.004  0.363
2019 Giannini LA, Xie SX, McMillan CT, Liang M, Williams A, Jester C, Rascovsky K, Wolk DA, Ash S, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. Divergent Patterns of TDP-43 and Tau Pathologies in Primary Progressive Aphasia. Annals of Neurology. PMID 30851133 DOI: 10.1002/Ana.25465  0.798
2019 Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, et al. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30846386 DOI: 10.1016/J.Jalz.2018.12.019  0.42
2019 Gibbons GS, Kim SJ, Robinson JL, Changolkar L, Irwin DJ, Shaw LM, Lee VM, Trojanowski JQ. Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau). Acta Neuropathologica Communications. 7: 34. PMID 30832741 DOI: 10.1186/S40478-019-0687-5  0.691
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Trojanowski JQ, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.717
2019 Henderson MX, Sengupta M, McGeary I, Zhang B, Olufemi MF, Brown H, Trojanowski JQ, Lee VMY. LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice. Acta Neuropathologica Communications. 7: 28. PMID 30808409 DOI: 10.1186/S40478-019-0679-5  0.317
2019 Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, ... ... Trojanowski JQ, et al. Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology. 18: 231-233. PMID 30784550 DOI: 10.1016/S1474-4422(19)30020-1  0.508
2019 Zhang B, Kehm V, Gathagan R, Leight SN, Trojanowski JQ, Lee VM, Luk KC. Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils. Methods in Molecular Biology (Clifton, N.J.). 1948: 45-57. PMID 30771169 DOI: 10.1007/978-1-4939-9124-2_5  0.538
2019 Karpowicz RJ, Trojanowski JQ, Lee VM. Transmission of α-synuclein seeds in neurodegenerative disease: recent developments. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30760864 DOI: 10.1038/S41374-019-0195-Z  0.499
2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, ... ... Trojanowski JQ, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathologica. PMID 30739198 DOI: 10.1007/S00401-019-01962-9  0.792
2019 Smith DH, Johnson VE, Trojanowski JQ, Stewart W. Chronic traumatic encephalopathy - confusion and controversies. Nature Reviews. Neurology. PMID 30664683 DOI: 10.1038/S41582-018-0114-8  0.327
2019 Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Schlepckow K, Caballero MÁA, Franzmeier N, Capell A, Fellerer K, Nuscher B, Eren E, Levin J, Deming Y, Piccio L, Karch CM, Cruchaga C, ... ... Trojanowski JQ, et al. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular Neurodegeneration. 14: 1. PMID 30630532 DOI: 10.1186/S13024-018-0301-5  0.595
2019 Toledo JB, Kovacs G, Kvartsberg H, Portelius E, Chen-Plotkin A, Zetterberg H, Blennow K, Shaw LM, Trojanowski JQ. P1-245: CSF BIOMARKER CORRELATES OF ARTAG NEUROPATHOLOGY Alzheimer's & Dementia. 15: P332-P332. DOI: 10.1016/J.Jalz.2019.06.800  0.565
2019 Phillips JS, Irwin D, Roll E, McMillan CT, Da Re F, Lee EB, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. P1-231: SENSITIVITY OF ATN CRITERIA IN AUTOPSY-CONFIRMED NON-AMNESTIC ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P324-P324. DOI: 10.1016/J.Jalz.2019.06.786  0.672
2019 Ewers M, Franzmeier N, Suárez-Calvet M, Morenas E, Piccio L, Cruchaga C, Robles Y, Trojanowski JQ, Shaw LM, Weiner MW, Haass C. O3-12-05: Increased Csf Soluble Trem2 Is Associated With Ameliorated Longitudinal Cognitive And Clinical Decline In Alzheimer'S Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4694  0.546
2019 Wisse L, Robin dF, Das SR, McMillan CT, Trojanowski JQ, Grossman M, Lee EB, Irwin D, Yushkevich PA, Wolk DA. O2-08-05: Pathological Drivers Of Neurodegeneration In Suspected Non-Alzheimer'S Pathophysiology Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4497  0.644
2019 Bernath M, Bhattacharyya S, Nho K, Barupal DK, Fiehn O, Baillie R, Risacher SL, Arnold M, Jacobson TY, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, Kaddurah-Daouk RF, Saykin AJ, et al. P4-116: Serum Triglycerides In Alzheimer'S Disease: Relation To Neuroimaging, Csf, And Genetic Variation Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.3777  0.37
2019 Waligorska T, Figurski MJ, Jeromin A, Chen-Plotkin A, Trojanowski JQ, Shaw LM. P3-232: VALIDATION STUDIES OF NEUROFILAMENT LIGHT AND Aβ-40 AND Aβ-42 ASSAYS IN HUMAN PLASMA USING THE SIMOA PLATFORM Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.3262  0.572
2019 Chen Q, Boeve BF, Schwarz CG, Reid RI, Tosakulwong N, Lesnick TG, Bove J, Brannelly P, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fields JA, ... ... Trojanowski JQ, et al. P2-329: Tracking White Matter Degeneration In Asymptomatic And Symptomatic Mapt Mutation Carriers With Dti Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2736  0.427
2019 Forsberg LK, Boeve BF, Boxer AL, Rosen HJ, Kornak J, Heuer HW, Fields JA, Brushaber D, Machulda MM, Sturm V, Staffaroni AM, Ljubenkov PA, Denver R, Ong E, Appleby B, ... ... Trojanowski JQ, et al. P2-314: THE MULTIDOMAIN IMPAIRMENT RATING (MIR) SCALE: INITIAL RELIABILITY DATA ON A MULTIDIMENSIONAL SCALE DESIGNED FOR FTLD SPECTRUM DISORDERS Alzheimer's & Dementia. 15: P707-P708. DOI: 10.1016/J.Jalz.2019.06.2721  0.577
2019 de Flores R, Wisse L, Das SR, Xie L, McMillan CT, Trojanowski JQ, Grossman M, Lee EB, Irwin D, Yushkevich PA, Wolk DA. P1-441: CONTRIBUTION OF TAU, TDP-43, β-AMYLOID AND α-SYNUCLEIN TO MEDIAL TEMPORAL LOBE ATROPHY Alzheimer's & Dementia. 15: P435-P435. DOI: 10.1016/J.Jalz.2019.06.1046  0.632
2018 Marek K, Chowdhury S, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Simuni T, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, et al. The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort. Annals of Clinical and Translational Neurology. 5: 1460-1477. PMID 30564614 DOI: 10.1002/Acn3.644  0.348
2018 Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, ... ... Trojanowski JQ, et al. Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders. Annals of Neurology. PMID 30549331 DOI: 10.1002/Ana.25392  0.823
2018 Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, Grossman M, Van Deerlin VM, Trojanowski JQ, et al. Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nature Medicine. PMID 30510257 DOI: 10.1038/S41591-018-0223-3  0.505
2018 Olsson B, Portelius E, Cullen NC, Sandelius Å, Zetterberg H, Andreasson U, Höglund K, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk D, McCluskey L, Elman L, Shaw LM, ... ... Trojanowski JQ, et al. Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders. Jama Neurology. PMID 30508027 DOI: 10.1001/Jamaneurol.2018.3746  0.775
2018 Molinuevo JL, Ayton S, Batrla R, Bednar MM, Bittner T, Cummings J, Fagan AM, Hampel H, Mielke MM, Mikulskis A, O'Bryant S, Scheltens P, Sevigny J, Shaw LM, Soares HD, ... ... Trojanowski JQ, et al. Current state of Alzheimer's fluid biomarkers. Acta Neuropathologica. 136: 821-853. PMID 30488277 DOI: 10.1007/S00401-018-1932-X  0.423
2018 Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, ... ... Trojanowski JQ, et al. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. Embo Molecular Medicine. PMID 30482868 DOI: 10.15252/Emmm.201809712  0.611
2018 Spiller KJ, Khan T, Dominique MA, Restrepo CR, Cotton-Samuel D, Levitan M, Jafar-Nejad P, Zhang B, Soriano A, Rigo F, Trojanowski JQ, Lee VM. Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice. Neurobiology of Disease. PMID 30458231 DOI: 10.1016/J.Nbd.2018.11.013  0.443
2018 Kun-Rodrigues C, Orme T, Carmona S, Hernandez DG, Ross OA, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Dawson T, Rosenthal L, ... ... Trojanowski JQ, et al. A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of Aging. PMID 30448004 DOI: 10.1016/J.Neurobiolaging.2018.10.019  0.369
2018 Shaw LM, Waligorska T, Fields L, Korecka M, Figurski M, Trojanowski JQ, Eichenlaub U, Wahl S, Quan M, Pontecorvo MJ, Lachno DR, Talbot JA, Andersen SW, Siemers ER, Dean RA. Derivation of cutoffs for the Elecsys amyloid β (1-42) assay in Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 10: 698-705. PMID 30426066 DOI: 10.1016/J.Dadm.2018.07.002  0.404
2018 Zhang B, Yao Y, Cornec AS, Oukoloff K, James MJ, Koivula P, Trojanowski JQ, Smith AB, Lee VM, Ballatore C, Brunden KR. A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. Molecular Neurodegeneration. 13: 59. PMID 30404654 DOI: 10.1186/S13024-018-0291-3  0.555
2018 Al-Janabi OM, Brown CA, Bahrani AA, Abner EL, Barber JM, Gold BT, Goldstein LB, Murphy RR, Nelson PT, Johnson NF, Shaw LM, Smith CD, Trojanowski JQ, Wilcock DM, Jicha GA. Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1 - 42 and Hypertension. Journal of Alzheimer's Disease : Jad. PMID 30400099 DOI: 10.3233/Jad-180663  0.646
2018 Placek K, Baer GM, Elman L, McCluskey L, Hennessy L, Ferraro PM, Lee EB, Lee VMY, Trojanowski JQ, Van Deerlin VM, Grossman M, Irwin DJ, McMillan CT. UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. 73: 190-199. PMID 30368160 DOI: 10.1016/J.Neurobiolaging.2018.09.031  0.769
2018 Nho K, Kueider-Paisley A, MahmoudianDehkordi S, Arnold M, Risacher SL, Louie G, Blach C, Baillie R, Han X, Kastenmüller G, Jia W, Xie G, Ahmad S, Hankemeier T, van Duijn CM, ... Trojanowski JQ, et al. Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30337152 DOI: 10.1016/J.Jalz.2018.08.012  0.407
2018 MahmoudianDehkordi S, Arnold M, Nho K, Ahmad S, Jia W, Xie G, Louie G, Kueider-Paisley A, Moseley MA, Thompson JW, St John Williams L, Tenenbaum JD, Blach C, Baillie R, Han X, ... ... Trojanowski JQ, et al. Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30337151 DOI: 10.1016/J.Jalz.2018.07.217  0.379
2018 Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ, et al. Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30321505 DOI: 10.1016/J.Jalz.2018.08.005  0.436
2018 Sandelius Å, Portelius E, Källén Å, Zetterberg H, Rot U, Olsson B, Toledo JB, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, ... ... Trojanowski JQ, et al. Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30321501 DOI: 10.1016/J.Jalz.2018.08.006  0.773
2018 Porta S, Xu Y, Restrepo CR, Kwong LK, Zhang B, Brown HJ, Lee EB, Trojanowski JQ, Lee VM. Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo. Nature Communications. 9: 4220. PMID 30310141 DOI: 10.1038/S41467-018-06548-9  0.684
2018 Alcolea D, Irwin DJ, Illán-Gala I, Muñoz L, Clarimón J, McMillan CT, Fortea J, Blesa R, Lee EB, Trojanowski JQ, Grossman M, Lleó A. Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30297518 DOI: 10.1136/Jnnp-2018-318993  0.776
2018 Gangishetti U, Christina Howell J, Perrin RJ, Louneva N, Watts KD, Kollhoff A, Grossman M, Wolk DA, Shaw LM, Morris JC, Trojanowski JQ, Fagan AM, Arnold SE, Hu WT. Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease. Alzheimer's Research & Therapy. 10: 98. PMID 30253800 DOI: 10.1186/S13195-018-0426-3  0.839
2018 Brettschneider J, Suh E, Robinson JL, Fang L, Lee EB, Irwin DJ, Grossman M, Van Deerlin VM, Lee VM, Trojanowski JQ. Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy. Journal of Neuropathology and Experimental Neurology. PMID 30203094 DOI: 10.1093/Jnen/Nly080  0.761
2018 Gibbons GS, Lee VMY, Trojanowski JQ. Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review. Jama Neurology. PMID 30193298 DOI: 10.1001/Jamaneurol.2018.2505  0.437
2018 McGurk L, Mojsilovic-Petrovic J, Van Deerlin VM, Shorter J, Kalb RG, Lee VM, Trojanowski JQ, Lee EB, Bonini NM. Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 6: 84. PMID 30157956 DOI: 10.1186/S40478-018-0586-1  0.486
2018 Schmitz M, Villar-Piqué A, Llorens F, Gmitterová K, Hermann P, Varges D, Zafar S, Lingor P, Vanderstichele H, Demeyer L, Stoops E, Trojanowski JQ, Lee VM, Zerr I. Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy. Molecular Neurobiology. PMID 30136097 DOI: 10.1007/S12035-018-1313-4  0.49
2018 McMillan CT, Lee EB, Jefferson-George K, Naj A, Van Deerlin VM, Trojanowski JQ, Wolk DA. Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance? Annals of Clinical and Translational Neurology. 5: 927-934. PMID 30128317 DOI: 10.1002/Acn3.581  0.73
2018 Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, Bader DA, Lee VMY, Trojanowski JQ, Liu Z, Sardiello M, Zheng H. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of Experimental Medicine. PMID 30108137 DOI: 10.1084/Jem.20172158  0.459
2018 Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, et al. Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30049650 DOI: 10.1016/J.Jalz.2018.05.004  0.385
2018 Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, ... ... Trojanowski JQ, et al. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathologica. PMID 29967939 DOI: 10.1007/s00401-018-1881-4  0.42
2018 Robinson JL, Corrada MM, Kovacs GG, Dominique M, Caswell C, Xie SX, Lee VM, Kawas CH, Trojanowski JQ. Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study. Acta Neuropathologica. PMID 29916037 DOI: 10.1007/S00401-018-1872-5  0.569
2018 Kovacs GG, Xie SX, Robinson JL, Lee EB, Smith DH, Schuck T, Lee VM, Trojanowski JQ. Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain. Acta Neuropathologica Communications. 6: 50. PMID 29891013 DOI: 10.1186/S40478-018-0552-Y  0.69
2018 Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, ... ... Trojanowski JQ, et al. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a Journal of Neurology. PMID 29878075 DOI: 10.1093/Brain/Awy146  0.829
2018 Henderson MX, Peng C, Trojanowski JQ, Lee VMY. LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons. Acta Neuropathologica Communications. 6: 45. PMID 29855356 DOI: 10.1186/S40478-018-0550-0  0.344
2018 Oukoloff K, Kovalevich J, Cornec AS, Yao Y, Owyang ZA, James M, Trojanowski JQ, Lee VM, Smith AB, Brunden KR, Ballatore C. Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines. Bioorganic & Medicinal Chemistry Letters. PMID 29764743 DOI: 10.1016/J.Bmcl.2018.05.010  0.418
2018 Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM. Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies. Nature. PMID 29743672 DOI: 10.1038/S41586-018-0104-4  0.477
2018 Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, ... ... Trojanowski JQ, et al. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet. Neurology. PMID 29724592 DOI: 10.1016/S1474-4422(18)30126-1  0.804
2018 Portelius E, Olsson B, Höglund K, Cullen NC, Kvartsberg H, Andreasson U, Zetterberg H, Sandelius Å, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, ... ... Trojanowski JQ, et al. Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta Neuropathologica. PMID 29700597 DOI: 10.1007/S00401-018-1851-X  0.773
2018 Roalf DR, Rupert P, Mechanic-Hamilton D, Brennan L, Duda JE, Weintraub D, Trojanowski JQ, Wolk D, Moberg PJ. Quantitative assessment of finger tapping characteristics in mild cognitive impairment, Alzheimer's disease, and Parkinson's disease. Journal of Neurology. PMID 29619565 DOI: 10.1007/S00415-018-8841-8  0.345
2018 Shi M, Tang L, Toledo JB, Ginghina C, Wang H, Aro P, Jensen PH, Weintraub D, Chen-Plotkin AS, Irwin DJ, Grossman M, McCluskey L, Elman LB, Wolk DA, Lee EB, ... ... Trojanowski JQ, et al. Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29604263 DOI: 10.1016/J.Jalz.2018.02.015  0.807
2018 Adler DH, Wisse LEM, Ittyerah R, Pluta JB, Ding SL, Xie L, Wang J, Kadivar S, Robinson JL, Schuck T, Trojanowski JQ, Grossman M, Detre JA, Elliott MA, Toledo JB, et al. Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology. Proceedings of the National Academy of Sciences of the United States of America. PMID 29592955 DOI: 10.1073/Pnas.1801093115  0.529
2018 Simuni T, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, et al. Longitudinal change of clinical and biological measures in early Parkinson's disease: Parkinson's progression markers initiative cohort. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29572948 DOI: 10.1002/Mds.27361  0.314
2018 Lleó A, Irwin DJ, Illán-Gala I, McMillan CT, Wolk DA, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes. Jama Neurology. PMID 29554190 DOI: 10.1001/Jamaneurol.2018.0118  0.805
2018 Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL. Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease. Nature Neuroscience. PMID 29507413 DOI: 10.1038/S41593-018-0101-9  0.382
2018 Trombetta BA, Carlyle BC, Koenig AM, Shaw LM, Trojanowski JQ, Wolk DA, Locascio JJ, Arnold SE. The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer's disease. Plos One. 13: e0193707. PMID 29505610 DOI: 10.1371/Journal.Pone.0193707  0.447
2018 Akhtar RS, Licata JP, Luk KC, Shaw LM, Trojanowski JQ, Lee VM. Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease. Journal of Neurochemistry. PMID 29500813 DOI: 10.1111/Jnc.14330  0.493
2018 Hansson O, Seibyl J, Stomrud E, Zetterberg H, Trojanowski JQ, Bittner T, Lifke V, Corradini V, Eichenlaub U, Batrla R, Buck K, Zink K, Rabe C, Blennow K, Shaw LM, et al. CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29499171 DOI: 10.1016/J.Jalz.2018.01.010  0.37
2018 Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM, ... ... Trojanowski JQ, et al. CSF tau and amyloid-beta predict cerebral synucleinopathy in autopsied Lewy body disorders. Neurology. PMID 29467305 DOI: 10.1212/Wnl.0000000000005166  0.801
2018 Spiller KJ, Restrepo CR, Khan T, Dominique MA, Fang TC, Canter RG, Roberts CJ, Miller KR, Ransohoff RM, Trojanowski JQ, Lee VM. Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy. Nature Neuroscience. PMID 29463850 DOI: 10.1038/S41593-018-0083-7  0.72
2018 Seo SW, Thibodeau MP, Perry DC, Hua A, Sidhu M, Sible I, Vargas JNS, Gaus SE, Rabinovici GD, Rankin KD, Boxer AL, Kramer JH, Rosen HJ, Gorno-Tempini ML, Grinberg LT, ... ... Trojanowski JQ, et al. Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration. Neurology. PMID 29453245 DOI: 10.1212/Wnl.0000000000005163  0.344
2018 Gibbons GS, Banks RA, Kim B, Changolkar L, Riddle DM, Leight SN, Irwin DJ, Trojanowski JQ, Lee VMY. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. Journal of Neuropathology and Experimental Neurology. PMID 29415231 DOI: 10.1093/Jnen/Nly010  0.63
2018 Wang H, Stewart T, Toledo JB, Ginghina C, Tang L, Atik A, Aro P, Shaw LM, Trojanowski JQ, Galasko DR, Edland S, Jensen PH, Shi M, Zhang J. A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment. Journal of Alzheimer's Disease : Jad. 61: 1541-1553. PMID 29376878 DOI: 10.3233/Jad-171013  0.437
2018 Wenning G, Trojanowski JQ, Kaufmann H, Rocca WA, Wisniewski T, Low PA. Is Multiple System Atrophy An Infectious Disease? Annals of Neurology. PMID 29293269 DOI: 10.1002/Ana.25132  0.347
2018 Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, ... ... Trojanowski JQ, et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet. Neurology. 17: 64-74. PMID 29263008 DOI: 10.1016/S1474-4422(17)30400-3  0.379
2018 Touroutoglou A, Brickhouse M, Krivensky S, Wong B, Getchell K, Lucente D, McGinnis SM, Dickerson BC, Boeve BF, Rosen HJ, Boxer AL, Bove J, Brushaber D, Coppola G, Dheel C, ... ... Trojanowski JQ, et al. P1-419: Using A Brain Network Approach To Predict Genetic Mutation In Individual Patients With Familial Frontotemporal Dementia Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.428  0.465
2018 Kornak J, Fields JA, Farmer S, Boeve BF, Rosen HJ, Boxer AL, Bove J, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fong J, Foroud TM, ... ... Trojanowski JQ, et al. P1-281: Nonlinear N-Score Estimation For Establishing Cognitive Norms From The National Alzheimer'S Coordinating Center (Nacc) Dataset Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.287  0.453
2018 Dumitrescu L, Deming Y, Lu Q, Beecham GW, Kunkle BW, Del-Aguila JL, Fernandez MV, Budde JP, Fagan AM, Jager PLD, Albert MS, Moghekar A, Riemenschneider M, Petersen RC, Barnes LL, ... ... Trojanowski JQ, et al. P1-139: The Contribution Of Sex-Specific Associations In Genetic Studies Of Alzheimer'S Disease Pathology Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.142  0.548
2017 Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre G, Lee EB, Lee VMY, Trojanowski JQ, Grossman M. Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain : a Journal of Neurology. PMID 29228211 DOI: 10.1093/Brain/Awx319  0.791
2017 Phillips JS, Da Re F, Dratch L, Xie SX, Irwin DJ, McMillan CT, Vaishnavi SN, Ferrarese C, Lee EB, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiology of Aging. 63: 75-87. PMID 29223682 DOI: 10.1016/J.Neurobiolaging.2017.11.008  0.795
2017 Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P. Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term. Acta Neuropathologica. PMID 29209768 DOI: 10.1007/S00401-017-1792-9  0.491
2017 He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, ... Trojanowski JQ, et al. Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nature Medicine. PMID 29200205 DOI: 10.1038/Nm.4443  0.581
2017 Tropea TF, Xie SX, Rick J, Chahine LM, Dahodwala N, Doshi J, Davatzikos C, Shaw LM, Van Deerlin V, Trojanowski JQ, Weintraub D, Chen-Plotkin AS. APOE, thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29168904 DOI: 10.1002/Mds.27204  0.615
2017 Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S, Chung CY, Garcia BA, Lee VM, Trojanowski JQ, Johnson FB, Berger SL, Bonini NM. TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Current Biology : Cb. PMID 29153328 DOI: 10.1016/J.Cub.2017.10.024  0.473
2017 Sheinerman KS, Toledo JB, Tsivinsky VG, Irwin D, Grossman M, Weintraub D, Hurtig HI, Chen-Plotkin A, Wolk DA, McCluskey LF, Elman LB, Trojanowski JQ, Umansky SR. Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases. Alzheimer's Research & Therapy. 9: 89. PMID 29121998 DOI: 10.1186/S13195-017-0316-0  0.771
2017 Narasimhan S, Guo JL, Changolkar L, Stieber A, McBride JD, Silva LV, He Z, Zhang B, Gathagan RJ, Trojanowski JQ, Lee VMY. Pathological tau strains from human brains recapitulate the diversity of tauopathies in non-transgenic mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29054878 DOI: 10.1523/Jneurosci.1230-17.2017  0.437
2017 Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, ... ... Trojanowski JQ, et al. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain : a Journal of Neurology. PMID 29053860 DOI: 10.1093/Brain/Awx254  0.468
2017 Mollenhauer B, Caspell-Garcia CJ, Coffey CS, Taylor P, Shaw LM, Trojanowski JQ, Singleton A, Frasier M, Marek K, Galasko D. Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls. Neurology. PMID 29030452 DOI: 10.1212/Wnl.0000000000004609  0.337
2017 Banks RA, Gibbons GS, Kim B, Xu H, Changolkar L, Leight SN, Riddle DM, Li C, Gathagan RJ, Brown HJ, Zhang B, Trojanowski JQ, Lee VM. GFP-mutant human tau transgenic mice develop tauopathy following CNS injections of Alzheimer's brain-derived pathological tau or synthetic mutant human tau fibrils. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28986461 DOI: 10.1523/Jneurosci.2393-17.2017  0.592
2017 Horgusluoglu-Moloch E, Nho K, Risacher SL, Kim S, Foroud T, Shaw LM, Trojanowski JQ, Aisen PS, Petersen RC, Jack CR, Lovestone S, Simmons A, Weiner MW, Saykin AJ. Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 60: 92-103. PMID 28941407 DOI: 10.1016/J.Neurobiolaging.2017.08.010  0.401
2017 Deck BL, Rick J, Xie SX, Chen-Plotkin A, Duda JE, Morley JF, Chahine LM, Dahodwala N, Trojanowski JQ, Weintraub D. Statins and Cognition in Parkinson's Disease. Journal of Parkinson's Disease. PMID 28922167 DOI: 10.3233/Jpd-171113  0.569
2017 Thakur P, Breger LS, Lundblad M, Wan OW, Mattsson B, Luk KC, Lee VMY, Trojanowski JQ, Björklund A. Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 28900002 DOI: 10.1073/Pnas.1710442114  0.357
2017 Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh E, Van Deerlin VM, Grossman M, Lee VM, Trojanowski JQ. Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration. Acta Neuropathologica Communications. 5: 68. PMID 28877758 DOI: 10.1186/S40478-017-0471-3  0.756
2017 Lassalas P, Oukoloff K, Makani V, James M, Tran V, Yao Y, Huang L, Vijayendran K, Monti L, Trojanowski JQ, Lee VM, Kozlowski MC, Smith AB, Brunden KR, Ballatore C. Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group. Acs Medicinal Chemistry Letters. 8: 864-868. PMID 28835803 DOI: 10.1021/Acsmedchemlett.7B00212  0.389
2017 Kovacs GG, Lee VM, Trojanowski JQ. Protein astrogliopathies in human neurodegenerative diseases and aging. Brain Pathology (Zurich, Switzerland). 27: 675-690. PMID 28805003 DOI: 10.1111/Bpa.12536  0.601
2017 Kovacs GG, Yousef A, Kaindl S, Lee VM, Trojanowski JQ. Connexin-43 and Aquaporin-4 are markers of ARTAG-related astroglial response. Neuropathology and Applied Neurobiology. PMID 28755467 DOI: 10.1111/Nan.12427  0.463
2017 Gold BT, Brown CA, Hakun JG, Shaw LM, Trojanowski JQ, Smith CD. Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults. Neurobiology of Aging. 58: 102-111. PMID 28719854 DOI: 10.1016/J.Neurobiolaging.2017.06.012  0.36
2017 Irwin DJ, Lleó A, Xie SX, McMillan CT, Wolk D, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD. Annals of Neurology. PMID 28719018 DOI: 10.1002/Ana.24996  0.804
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Trojanowski JQ, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.726
2017 Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron. PMID 28669544 DOI: 10.1016/J.Neuron.2017.05.037  0.707
2017 Gendron TF, Daughrity LM, Heckman MG, Diehl NN, Wuu J, Miller TM, Pastor P, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Benatar M, Silani V, Glass JD, et al. Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis. Annals of Neurology. PMID 28628244 DOI: 10.1002/Ana.24980  0.638
2017 McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, ... ... Trojanowski JQ, et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. PMID 28592453 DOI: 10.1212/Wnl.0000000000004058  0.632
2017 Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, ... ... Trojanowski JQ, et al. Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of Neuropathology and Experimental Neurology. PMID 28591867 DOI: 10.1093/Jnen/Nlx041  0.761
2017 Nho K, Kim S, Horgusluoglu E, Risacher SL, Shen L, Kim D, Lee S, Foroud T, Shaw LM, Trojanowski JQ, Aisen PS, Petersen RC, Jack CR, Weiner MW, Green RC, et al. Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease. Bmc Medical Genomics. 10: 29. PMID 28589856 DOI: 10.1186/S12920-017-0267-0  0.377
2017 Deters KD, Risacher SL, Kim S, Nho K, West JD, Blennow K, Zetterberg H, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ. Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 28550246 DOI: 10.3233/Jad-161114  0.448
2017 Akhtar RS, Xie SX, Chen YJ, Rick J, Gross RG, Nasrallah IM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS, Hurtig HI, Siderowf AD, Dubroff JG, Weintraub D. Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia. Plos One. 12: e0177924. PMID 28542444 DOI: 10.1371/Journal.Pone.0177924  0.611
2017 Cornec AS, Monti L, Kovalevich J, Makani V, James MJ, Vijayendran KG, Oukoloff K, Yao Y, Lee VM, Trojanowski JQ, Smith Iii AB, Brunden KR, Ballatore C. Multi-targeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases. Journal of Medicinal Chemistry. PMID 28530811 DOI: 10.1021/Acs.Jmedchem.7B00475  0.562
2017 Henderson MX, Chung CH, Riddle DM, Zhang B, Gathagan RJ, Seeholzer SH, Trojanowski JQ, Lee VMY. Unbiased proteomics of early Lewy body formation model implicates active microtubule affinity-regulating kinases (MARKs) in synucleinopathies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28522732 DOI: 10.1523/Jneurosci.2705-16.2017  0.373
2017 Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, et al. Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease. Plos One. 12: e0175674. PMID 28520803 DOI: 10.1371/Journal.Pone.0175674  0.337
2017 Giannini LAA, Irwin DJ, McMillan CT, Ash S, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, Trojanowski JQ, Grossman M. Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia. Neurology. PMID 28515265 DOI: 10.1212/Wnl.0000000000004034  0.809
2017 Brennan L, Devlin KM, Xie SX, Mechanic-Hamilton D, Tran B, Hurtig HH, Chen-Plotkin A, Chahine LM, Morley JF, Duda JE, Roalf DR, Dahodwala N, Rick J, Trojanowski JQ, Moberg PJ, et al. Neuropsychological Subgroups in Non-Demented Parkinson's Disease: A Latent Class Analysis. Journal of Parkinson's Disease. PMID 28387684 DOI: 10.3233/Jpd-171081  0.597
2017 Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, Lee VM. Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease. Neuropathology and Applied Neurobiology. PMID 28386933 DOI: 10.1111/Nan.12402  0.518
2017 Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, ... ... Trojanowski JQ, et al. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science Translational Medicine. 9. PMID 28356511 DOI: 10.1126/Scitranslmed.Aai7866  0.603
2017 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ, et al. Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28342697 DOI: 10.1016/J.Jalz.2016.11.007  0.397
2017 Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, ... ... Trojanowski JQ, et al. Metabolic network failures in Alzheimer's disease-A biochemical road map. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28341160 DOI: 10.1016/J.Jalz.2017.01.020  0.414
2017 Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, ... Trojanowski JQ, et al. Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. Journal of Neuropathology and Experimental Neurology. PMID 28340083 DOI: 10.1093/Jnen/Nlx007  0.791
2017 Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, ... ... Trojanowski JQ, et al. Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta Neuropathologica. PMID 28247064 DOI: 10.1007/s00401-017-1685-y  0.479
2017 Sposato LA, Ruíz Vargas E, Riccio PM, Toledo JB, Trojanowski JQ, Kukull WA, Cipriano LE, Nucera A, Whitehead SN, Hachinski V. Milder Alzheimer's disease pathology in heart failure and atrial fibrillation. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28174071 DOI: 10.1016/J.Jalz.2016.12.002  0.373
2017 Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, et al. Typical and atypical pathology in primary progressive aphasia variants. Annals of Neurology. PMID 28133816 DOI: 10.1002/Ana.24885  0.342
2017 Lee EB, Porta S, Michael Baer G, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM, Irwin DJ, Van Deerlin VM, Trojanowski JQ. Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration. Acta Neuropathologica. PMID 28130640 DOI: 10.1007/S00401-017-1679-9  0.778
2017 Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB. Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies. Acs Chemical Neuroscience. 8: 5-7. PMID 28095679 DOI: 10.1021/Acschemneuro.6B00384  0.501
2017 Ono M, Sahara N, Kumata K, Ji B, Ni R, Koga S, Dickson DW, Trojanowski JQ, Lee VM, Yoshida M, Hozumi I, Yoshiyama Y, van Swieten JC, Nordberg A, Suhara T, et al. Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain : a Journal of Neurology. PMID 28087578 DOI: 10.1093/Brain/Aww339  0.556
2017 Cooper CA, Jain N, Gallagher MD, Weintraub D, Xie SX, Berlyand Y, Espay AJ, Quinn J, Edwards KL, Montine T, Van Deerlin VM, Trojanowski J, Zabetian CP, Chen-Plotkin AS. Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype. Annals of Clinical and Translational Neurology. 4: 15-25. PMID 28078311 DOI: 10.1002/Acn3.371  0.707
2017 Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, ... ... Trojanowski JQ, et al. Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. The Lancet. Neurology. 16: 55-65. PMID 27979356 DOI: 10.1016/S1474-4422(16)30291-5  0.785
2017 Brown CA, Johnson NF, Anderson-Mooney AJ, Jicha GA, Shaw LM, Trojanowski JQ, Van Eldik LJ, Schmitt FA, Smith CD, Gold BT. Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease. Neuroimage. Clinical. 13: 106-115. PMID 27942453 DOI: 10.1016/J.Nicl.2016.11.024  0.366
2017 Wisse LE, Adler D, Ittyerah R, Pluta JB, Ding S, Xie L, Wang J, Kadivar S, Robinson JL, Schuck T, Trojanowski JQ, Grossman M, Detre JA, Elliott MA, Toledo JB, et al. ALZHEIMER’S DISEASE AND THE HIPPOCAMPUS: NOVEL INSIGHTS FROM AN EX VIVO COMPUTATIONAL ATLAS COMBINING MRI AND HISTOLOGY Alzheimer's & Dementia. 13: P1534-P1535. DOI: 10.1016/J.Jalz.2017.07.669  0.48
2017 Gangishetti U, Perrin RJ, Arnold SE, Fagan AM, Morris JC, Trojanowski JQ, Hu WT. VALIDATING NON-AMYLOID, NON-TAU CSF BIOMARKERS FOR ALZHEIMER'S DISEASE IN THE PRE-SYMPTOMATIC, MCI, AND DEMENTIA STAGES: A MULTI-CENTER STUDY Alzheimer's & Dementia. 13: P1513-P1514. DOI: 10.1016/J.Jalz.2017.07.632  0.833
2017 Deming Y, Kapoor M, Li Z, Harari O, Black K, Del-Aguila JL, Carrell D, Cai Y, Fernandez MV, Budde JP, Ma S, Saef B, Howells B, Huang K, Bertelsen S, ... ... Trojanowski JQ, et al. CEREBROSPINAL FLUID ENDOPHENOTYPES PROVIDE INSIGHT INTO BIOLOGY UNDERLYING ALZHEIMER'S DISEASE Alzheimer's & Dementia. 13: P218-P219. DOI: 10.1016/J.Jalz.2017.07.096  0.4
2017 Dheel CM, Boeve BF, Rosen HJ, Boxer AL, Coppola G, Dickerson BC, Faber K, Fields JA, Foroud TM, Gavrilova RH, Ghoshal N, Goldman J, Graff-Radford N, Grossman M, Heuer H, ... ... Trojanowski JQ, et al. [P1-254]: CHARACTERISTICS AND PROGRESS ON THE INITIAL 209 SUBJECTS IN THE LONGITUDINAL EVALUATION OF FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS (LEFFTDS) PROTOCOL Alzheimer's & Dementia. 13: P345-P345. DOI: 10.1016/J.Jalz.2017.06.270  0.451
2017 Da Re F, Phillips JS, Dratch L, Ferrarese C, Irwin DJ, McMillan CT, Lee E, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. [P4-238]: AMNESTIC AND NON-AMNESTIC PHENOTYPES OF ALZHEIMER'S DISEASE: AN MRI-BASED PHASING ANALYSIS Alzheimer's & Dementia. 13: P1365-P1366. DOI: 10.1016/J.Jalz.2017.06.2106  0.743
2017 Shaw LM, Waligorska T, Fields L, Korecka M, Figurski MJ, Trojanowski JQ, Eichenlaub U, Wahl S, Quan M, Lachno DR, Talbot JA, Andersen SW, Siemers ER, Dean RA. DERIVING A CUT-OFF FOR THE ELECSYS® β-AMYLOID (1–42) IMMUNOASSAY FOR USE IN CLINICAL TRIALS SUPPORTED BY ELI LILLY FOR PATIENTS WITH CLINICALLY DEFINED ALZHEIMER’S DISEASE (AD) Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.2022  0.362
2016 Yushkevich PA, Wisse L, Adler D, Ittyerah R, Pluta JB, Robinson JL, Schuck T, Trojanowski JQ, Grossman M, Detre JA, Elliott MA, Toledo JB, Weixia Liu, Pickup S, Das SR, et al. A framework for informing segmentation of in vivo MRI with information derived from ex vivo imaging: Application in the medial temporal lobe. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2016: 6014-6017. PMID 28269623 DOI: 10.1109/EMBC.2016.7592099  0.325
2016 Yushkevich PA, Wisse L, Adler D, Ittyerah R, Pluta JB, Robinson JL, Schuck T, Trojanowski JQ, Grossman M, Detre JA, Elliott MA, Toledo JB, Liu W, Pickup S, Das SR, ... ... Trojanowski JQ, ... ... Trojanowski JQ, et al. A framework for informing segmentation of in vivo MRI with information derived from ex vivo imaging: Application in the medial temporal lobe. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2016: 6014-6017. PMID 28227881 DOI: 10.1109/EMBC.2016.7592099  0.325
2016 Spotorno N, McMillan CT, Irwin DJ, Clark R, Lee EB, Trojanowski JQ, Weintraub D, Grossman M. Decision-Making Deficits Associated with Amyloidosis in Lewy Body Disorders. Frontiers in Human Neuroscience. 10: 693. PMID 28123364 DOI: 10.3389/Fnhum.2016.00693  0.785
2016 Kovacs GG, Kwong LK, Grossman M, Irwin DJ, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain Pathology (Zurich, Switzerland). PMID 28019685 DOI: 10.1111/Bpa.12482  0.784
2016 Brunden KR, Lee VM, Smith AB, Trojanowski JQ, Ballatore C. Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs. Neurobiology of Disease. PMID 28012891 DOI: 10.1016/J.Nbd.2016.12.021  0.513
2016 Dong A, Toledo JB, Honnorat N, Doshi J, Varol E, Sotiras A, Wolk D, Trojanowski JQ, Davatzikos C. Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers. Brain : a Journal of Neurology. PMID 28003242 DOI: 10.1093/Brain/Aww319  0.435
2016 Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JS, Leroux F, Herledan A, Demiautte F, ... ... Trojanowski JQ, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathologica. PMID 27933404 DOI: 10.1007/S00401-016-1652-Z  0.51
2016 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Morris JC, Petersen RC, Salazar J, Saykin AJ, Shaw LM, Toga AW, ... Trojanowski JQ, et al. The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27931796 DOI: 10.1016/J.Jalz.2016.10.006  0.419
2016 McMillan CT, Irwin DJ, Nasrallah I, Phillips JS, Spindler M, Rascovsky K, Ternes K, Jester C, Wolk DA, Kwong LK, Lee VM, Lee EB, Trojanowski JQ, Grossman M. Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. Acta Neuropathologica. PMID 27815633 DOI: 10.1007/S00401-016-1640-3  0.747
2016 Guo JL, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VM. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. The Journal of Experimental Medicine. PMID 27810929 DOI: 10.1084/Jem.20160833  0.593
2016 Khanna MR, Kovalevich J, Lee VM, Trojanowski JQ, Brunden KR. Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 1051-1065. PMID 27751442 DOI: 10.1016/J.Jalz.2016.06.006  0.604
2016 Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, et al. Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. Scientific Reports. 6: 34904. PMID 27721502 DOI: 10.1038/Srep34904  0.527
2016 Brettschneider J, Irwin DJ, Boluda S, Byrne MD, Fang L, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Toledo JB, Grossman M, Hurtig H, Dengler R, Petri S, Lee VM, ... Trojanowski JQ, et al. Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type. Neuropathology and Applied Neurobiology. PMID 27716988 DOI: 10.1111/Nan.12362  0.651
2016 Mattsson N, Zetterberg H, Janelidze S, Insel PS, Andreasson U, Stomrud E, Palmqvist S, Baker D, Tan Hehir CA, Jeromin A, Hanlon D, Song L, Shaw LM, Trojanowski JQ, Weiner MW, et al. Plasma tau in Alzheimer disease. Neurology. PMID 27694257 DOI: 10.1212/Wnl.0000000000003246  0.459
2016 James BD, Wilson RS, Boyle PA, Trojanowski JQ, Bennett DA, Schneider JA. TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia. Brain : a Journal of Neurology. PMID 27694152 DOI: 10.1093/Brain/Aww224  0.458
2016 Makani V, Zhang B, Han H, Yao Y, Lassalas P, Lou K, Paterson I, Lee VM, Trojanowski JQ, Ballatore C, Smith AB, Brunden KR. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathologica Communications. 4: 106. PMID 27687527 DOI: 10.1186/S40478-016-0378-4  0.526
2016 Spiller KJ, Restrepo CR, Khan T, Stieber AM, Kwong LK, Trojanowski JQ, Lee VM. Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice. Acta Neuropathologica Communications. 4: 105. PMID 27687289 DOI: 10.1186/S40478-016-0377-5  0.476
2016 Placek K, Massimo L, Olm C, Ternes K, Firn K, Van Deerlin V, Lee EB, Trojanowski JQ, Lee VM, Irwin D, Grossman M, McMillan CT. Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence. Neurology. PMID 27683847 DOI: 10.1212/WNL.0000000000003250  0.768
2016 Kun-Rodrigues C, Ross OA, Orme T, Shepherd C, Parkkinen L, Darwent L, Hernandez D, Ansorge O, Clark LN, Honig LS, Marder K, Lemstra A, Scheltens P, van der Flier W, Louwersheimer E, ... ... Trojanowski JQ, et al. Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies. Neurobiology of Aging. PMID 27666590 DOI: 10.1016/J.Neurobiolaging.2016.08.023  0.391
2016 Wisse LE, Adler DH, Ittyerah R, Pluta JB, Robinson JL, Schuck T, Trojanowski JQ, Grossman M, Detre JA, Elliott MA, Toledo JB, Liu W, Pickup S, Das SR, Wolk DA, et al. Comparison of In Vivo and Ex Vivo MRI of the Human Hippocampal Formation in the Same Subjects. Cerebral Cortex (New York, N.Y. : 1991). PMID 27664967 DOI: 10.1093/Cercor/Bhw299  0.419
2016 Luk KC, Covell DJ, Kehm VM, Zhang B, Song IY, Byrne MD, Pitkin RM, Decker SC, Trojanowski JQ, Lee VM. Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity. Cell Reports. 16: 3373-87. PMID 27653697 DOI: 10.1016/J.Celrep.2016.08.053  0.467
2016 Davis MY, Johnson CO, Leverenz JB, Weintraub D, Trojanowski JQ, Chen-Plotkin A, Van Deerlin VM, Quinn JF, Chung KA, Peterson-Hiller AL, Rosenthal LS, Dawson TM, Albert MS, Goldman JG, Stebbins GT, et al. Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease. Jama Neurology. PMID 27571329 DOI: 10.1001/Jamaneurol.2016.2245  0.619
2016 McMillan CT, Boyd C, Gross RG, Weinstein J, Firn K, Toledo JB, Rascovsky K, Shaw L, Wolk DA, Irwin DJ, Lee EB, Trojanowski JQ, Grossman M. Multimodal imaging evidence of pathology-mediated disease distribution in corticobasal syndrome. Neurology. PMID 27543644 DOI: 10.1212/Wnl.0000000000003119  0.767
2016 Nho K, Horgusluoglu E, Kim S, Risacher SL, Kim D, Foroud T, Aisen PS, Petersen RC, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW, Green RC, Toga AW, Saykin AJ, et al. Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer's disease. Bmc Medical Genomics. 9: 30. PMID 27535542 DOI: 10.1186/S12920-016-0190-9  0.37
2016 Rey NL, Steiner JA, Maroof N, Luk KC, Madaj Z, Trojanowski JQ, Lee VM, Brundin P. Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease. The Journal of Experimental Medicine. PMID 27503075 DOI: 10.1084/Jem.20160368  0.49
2016 Akhtar RS, Xie SX, Brennan L, Pontecorvo MJ, Hurtig HI, Trojanowski JQ, Weintraub D, Siderowf AD. Amyloid-Beta Positron Emission Tomography Imaging of Alzheimer's Pathology in Parkinson's Disease Dementia. Movement Disorders Clinical Practice. 3: 367-375. PMID 27500181 DOI: 10.1002/Mdc3.12290  0.45
2016 Durazzo TC, Korecka M, Trojanowski JQ, Weiner MW, O' Hara R, Ashford JW, Shaw LM. Active Cigarette Smoking in Cognitively-Normal Elders and Probable Alzheimer's Disease is Associated with Elevated Cerebrospinal Fluid Oxidative Stress Biomarkers. Journal of Alzheimer's Disease : Jad. PMID 27472882 DOI: 10.3233/Jad-160413  0.315
2016 Spiller KJ, Cheung CJ, Restrepo CR, Kwong LK, Stieber AM, Trojanowski JQ, Lee VM. Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7707-17. PMID 27445147 DOI: 10.1523/Jneurosci.1457-16.2016  0.476
2016 Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovičić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, ... ... Trojanowski JQ, et al. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. PMID 27321923 DOI: 10.1016/J.Neuron.2016.05.021  0.475
2016 Abner EL, Jicha GA, Shaw LM, Trojanowski JQ, Goetzl EJ. Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging. Annals of Clinical and Translational Neurology. 3: 399-403. PMID 27231710 DOI: 10.1002/Acn3.309  0.424
2016 Lim NS, Swanson CR, Cherng HR, Unger TL, Xie SX, Weintraub D, Marek K, Stern MB, Siderowf A, Trojanowski JQ, Chen-Plotkin AS. Plasma EGF and cognitive decline in Parkinson's disease and Alzheimer's disease. Annals of Clinical and Translational Neurology. 3: 346-55. PMID 27231704 DOI: 10.1002/Acn3.299  0.782
2016 Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET. "New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS). Journal of Neuropathology and Experimental Neurology. PMID 27209644 DOI: 10.1093/Jnen/Nlw033  0.69
2016 Santos-Santos MA, Mandelli ML, Binney RJ, Ogar J, Wilson SM, Henry ML, Hubbard HI, Meese M, Attygalle S, Rosenberg L, Pakvasa M, Trojanowski JQ, Grinberg LT, Rosen H, Boxer AL, et al. Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. Jama Neurology. PMID 27111692 DOI: 10.1001/Jamaneurol.2016.0412  0.351
2016 Kang JH, Mollenhauer B, Coffey CS, Toledo JB, Weintraub D, Galasko DR, Irwin DJ, Van Deerlin V, Chen-Plotkin AS, Caspell-Garcia C, Waligórska T, Taylor P, Shah N, Pan S, Zero P, ... ... Trojanowski JQ, et al. CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study. Acta Neuropathologica. PMID 27021906 DOI: 10.1007/S00401-016-1552-2  0.714
2016 Kovalevich J, Cornec AS, Yao Y, James M, Crowe A, Lee VM, Trojanowski JQ, Smith AB, Ballatore C, Brunden KR. Characterization of brain-penetrant pyrimidine-containing molecules with differential microtubule-stabilizing activities developed as potential therapeutic agents for Alzheimer's disease and related tauopathies. The Journal of Pharmacology and Experimental Therapeutics. PMID 26980057 DOI: 10.1124/Jpet.115.231175  0.533
2016 Brennan L, Siderowf A, Rubright JD, Rick J, Dahodwala N, Duda JE, Hurtig H, Stern M, Xie SX, Rennert L, Karlawish J, Shea JA, Trojanowski JQ, Weintraub D. The Penn Parkinson's Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson's disease. Parkinsonism & Related Disorders. PMID 26923524 DOI: 10.1016/J.Parkreldis.2016.02.020  0.319
2016 Berlyand Y, Weintraub D, Xie SX, Mellis IA, Doshi J, Rick J, McBride J, Davatzikos C, Shaw LM, Hurtig H, Trojanowski JQ, Chen-Plotkin AS. An Alzheimer's Disease-Derived Biomarker Signature Identifies Parkinson's Disease Patients with Dementia. Plos One. 11: e0147319. PMID 26812251 DOI: 10.1371/Journal.Pone.0147319  0.656
2016 Trojanowski J. Transmission of neuronal and glial tau pathology: new models for developing disease modifying therapy for Alzheimer's and related tauopathies Neurobiology of Aging. 39: S6. DOI: 10.1016/J.Neurobiolaging.2016.01.037  0.422
2016 Sheinerman KS, Tsivinsky VG, Toledo JB, McBride J, Grant EA, Fagan AM, Trojanowski JQ, Umansky SR. 05-05-06: Circulating Brain-Enriched Micrornas as Biomarkers for Early Detection And Differential Diagnosis of Alzheimer's Disease Alzheimer's & Dementia. 12: P389-P390. DOI: 10.1016/J.Jalz.2016.06.734  0.401
2016 Deming Y, Harari O, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez V, Budde J, Ma S, Saef B, Bertelsen S, Kauwe J, Fagan AM, Holtzman DM, Morris JC, ... ... Trojanowski JQ, et al. Cerebrospinal Fluid Levels Of Amyloid Beta And Tau As Endophenotypes Reveal Novel Variants Potentially Informative For Alzheimer'S Disease Alzheimers & Dementia. 12: 252. DOI: 10.1016/J.Jalz.2016.06.452  0.549
2016 Toledo JB, Thompson JW, Williams LSJ, Tenenbaum J, Han X, Baillie RA, Thambisetty M, Casanova R, Varma S, Legido-Quigley C, Mahmoudiandehkordi S, Motsinger-Reif A, Zhu H, Kastenmüller G, Suhre K, ... ... Trojanowski JQ, et al. The Alzheimer’S Metabolome: Relationship To Pathological Markers And Cognitive Decline In The Alzheimer’S Disease Neuroimaging Initiative (Adni) Alzheimers & Dementia. 12: 164. DOI: 10.1016/J.Jalz.2016.06.275  0.345
2016 Shinotoh H, Sahara N, Shimada H, Ikeuchi T, Shunske K, Strogonsky AJ, Nishioka K, Hanyu H, Swieten JCv, Ono M, Kimura Y, Hirano S, Ishii K, Zhang M, Trojanowski JQ, et al. [11C]Pbb3 Pet Visualizes Tau Aggregates In Patients With Ftdp-17 Mapt Gene Mutation Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.217  0.462
2016 Stoops E, Majbour N, Mauroo K, Demeyer L, Lashuel H, Trojanowski JQ, Lee VM, Agnaf OE, Vanderstichele HM. Performance Evaluation Of New Absorbance-Based Elisas For Measuring Different Alpha-Synuclein (A-Syn) Species In Csf And Plasma Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.1330  0.429
2015 Lazaris A, Hwang KS, Goukasian N, Ramirez LM, Eastman J, Blanken AE, Teng E, Gylys K, Cole G, Saykin AJ, Shaw LM, Trojanowski JQ, Jagust WJ, Weiner MW, Apostolova LG, et al. Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding. Neurology. Genetics. 1: e22. PMID 27066559 DOI: 10.1212/Nxg.0000000000000022  0.38
2015 Toledo JB, Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, ... ... Trojanowski JQ, et al. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathologica. PMID 26721587 DOI: 10.1007/S00401-015-1526-9  0.812
2015 Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, ... ... Trojanowski JQ, et al. Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study. Alzheimer's & Dementia (Amsterdam, Netherlands). 1: 339-348. PMID 26693175 DOI: 10.1016/J.Dadm.2015.06.008  0.736
2015 Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, ... ... Trojanowski JQ, et al. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica. PMID 26659578 DOI: 10.1007/S00401-015-1509-X  0.756
2015 Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM, Grossman M, Trojanowski JQ. Deep Clinical and Neuropathological Phenotyping of Pick's Disease. Annals of Neurology. PMID 26583316 DOI: 10.1002/Ana.24559  0.793
2015 Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ. Semi-Automated Digital Image Analysis of Pick's Disease and TDP-3 Proteinopathy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. PMID 26538548 DOI: 10.1369/0022155415614303  0.797
2015 Zetterberg H, Skillbäck T, Mattsson N, Trojanowski JQ, Portelius E, Shaw LM, Weiner MW, Blennow K. Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression. Jama Neurology. 1-8. PMID 26524180 DOI: 10.1001/Jamaneurol.2015.3037  0.375
2015 Amlie-Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, Van Deerlin VM, Gregory BD, Kwong LK, Trojanowski JQ, Lee VM, Wang LS, Lee EB. Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin. Plos One. 10: e0141836. PMID 26510133 DOI: 10.1371/Journal.Pone.0141836  0.632
2015 Walker AK, Tripathy K, Restrepo CR, Ge G, Xu Y, Kwong LK, Trojanowski JQ, Lee VM. An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Human Molecular Genetics. PMID 26476406 DOI: 10.1093/Hmg/Ddv424  0.544
2015 Bilello M, Doshi J, Nabavizadeh SA, Toledo JB, Erus G, Xie SX, Trojanowski JQ, Han X, Davatzikos C. Correlating Cognitive Decline with White Matter Lesion and Brain Atrophy Magnetic Resonance Imaging Measurements in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26402108 DOI: 10.3233/Jad-150400  0.417
2015 Lewczuk P, Kornhuber J, Toledo JB, Trojanowski JQ, Knapik-Czajka M, Peters O, Wiltfang J, Shaw LM. Validation of the Erlangen Score Algorithm for the Prediction of the Development of Dementia due to Alzheimer's Disease in Pre-Dementia Subjects. Journal of Alzheimer's Disease : Jad. 48: 433-41. PMID 26402007 DOI: 10.3233/Jad-150342  0.4
2015 Portelius E, Zetterberg H, Skillbäck T, Törnqvist U, Andreasson U, Trojanowski JQ, Weiner MW, Shaw LM, Mattsson N, Blennow K. Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease. Brain : a Journal of Neurology. PMID 26373605 DOI: 10.1093/Brain/Awv267  0.379
2015 Pigott K, Rick J, Xie SX, Hurtig H, Chen-Plotkin A, Duda JE, Morley JF, Chahine LM, Dahodwala N, Akhtar RS, Siderowf A, Trojanowski JQ, Weintraub D. Longitudinal study of normal cognition in Parkinson disease. Neurology. PMID 26362285 DOI: 10.1212/Wnl.0000000000002001  0.579
2015 O'Hearn EE, Hwang HS, Holmes SE, Rudnicki DD, Chung DW, Seixas AI, Cohen RL, Ross CA, Trojanowski JQ, Pletnikova O, Troncoso JC, Margolis RL. Neuropathology and Cellular Pathogenesis of Spinocerebellar Ataxia Type 12. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26340331 DOI: 10.1002/Mds.26348  0.31
2015 Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, ... Trojanowski JQ, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26327235 DOI: 10.1016/J.Jalz.2015.07.492  0.755
2015 Mata IF, Leverenz JB, Weintraub D, Trojanowski JQ, Chen-Plotkin A, Van Deerlin VM, Ritz B, Rausch R, Factor SA, Wood-Siverio C, Quinn JF, Chung KA, Peterson-Hiller AL, Goldman JG, Stebbins GT, et al. GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26296077 DOI: 10.1002/Mds.26359  0.58
2015 Toledo JB, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, ... ... Trojanowski JQ, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a Journal of Neurology. 138: 2701-15. PMID 26220940 DOI: 10.1093/Brain/Awv199  0.609
2015 Torralva T, Sposato LA, Riccio PM, Gleichgerrcht E, Roca M, Toledo JB, Trojanowski JQ, Kukull WA, Manes F, Hachinski V. Role of brain infarcts in behavioral variant frontotemporal dementia: Clinicopathological characterization in the National Alzheimer's Coordinating Center database. Neurobiology of Aging. 36: 2861-8. PMID 26220367 DOI: 10.1016/J.Neurobiolaging.2015.06.026  0.411
2015 Walker AK, Spiller KJ, Ge G, Zheng A, Xu Y, Zhou M, Tripathy K, Kwong LK, Trojanowski JQ, Lee VM. Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. Acta Neuropathologica. PMID 26197969 DOI: 10.1007/S00401-015-1460-X  0.497
2015 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Donohue MC, Green RC, Harvey D, Jack CR, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw L, ... ... Trojanowski JQ, et al. Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 865-84. PMID 26194320 DOI: 10.1016/J.Jalz.2015.04.005  0.439
2015 Kang JH, Korecka M, Figurski MJ, Toledo JB, Blennow K, Zetterberg H, Waligorska T, Brylska M, Fields L, Shah N, Soares H, Dean RA, Vanderstichele H, Petersen RC, Aisen PS, ... ... Trojanowski JQ, et al. The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 772-91. PMID 26194312 DOI: 10.1016/J.Jalz.2015.05.003  0.469
2015 Iba M, McBride JD, Guo JL, Zhang B, Trojanowski JQ, Lee VM. Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections. Acta Neuropathologica. PMID 26150341 DOI: 10.1007/S00401-015-1458-4  0.585
2015 Robinson JL, Suh E, Wood EM, Lee EB, Coslett HB, Raible K, Lee VM, Trojanowski JQ, Van Deerlin VM. Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His. Acta Neuropathologica Communications. 3: 42. PMID 26141825 DOI: 10.1186/S40478-015-0219-X  0.654
2015 Fitts W, Weintraub D, Massimo L, Chahine L, Chen-Plotkin A, Duda JE, Hurtig HI, Rick J, Trojanowski JQ, Dahodwala N. Caregiver report of apathy predicts dementia in Parkinson's disease. Parkinsonism & Related Disorders. 21: 992-5. PMID 26117435 DOI: 10.1016/J.Parkreldis.2015.06.009  0.604
2015 Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of Disease. 82: 185-199. PMID 26093169 DOI: 10.1016/J.Nbd.2015.06.003  0.469
2015 Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, ... ... Trojanowski JQ, et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 6: 7247. PMID 26077951 DOI: 10.1038/Ncomms8247  0.671
2015 Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, Green RC, Harvey D, Jack CR, Jagust W, Luthman J, Morris JC, Petersen RC, Saykin AJ, Shaw L, ... ... Trojanowski JQ, et al. 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: e1-e120. PMID 26073027 DOI: 10.1016/J.Jalz.2014.11.001  0.445
2015 Wheeler JM, McMillan PJ, Hawk M, Iba M, Robinson L, Xu GJ, Dombroski BA, Jeong D, Dichter MA, Juul H, Loomis E, Raskind M, Leverenz JB, Trojanowski JQ, Lee VM, et al. High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration. Acta Neuropathologica Communications. 3: 33. PMID 26041339 DOI: 10.1186/S40478-015-0210-6  0.591
2015 Suh E, Lee EB, Neal D, Wood EM, Toledo JB, Rennert L, Irwin DJ, McMillan CT, Krock B, Elman LB, McCluskey LF, Grossman M, Xie SX, Trojanowski JQ, Van Deerlin VM. Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration. Acta Neuropathologica. PMID 26022924 DOI: 10.1007/S00401-015-1445-9  0.774
2015 Risacher SL, Kim S, Nho K, Foroud T, Shen L, Petersen RC, Jack CR, Beckett LA, Aisen PS, Koeppe RA, Jagust WJ, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ, et al. APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 25960448 DOI: 10.1016/J.Jalz.2015.03.003  0.349
2015 Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, ... ... Trojanowski JQ, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. Plos One. 10: e0125614. PMID 25933020 DOI: 10.1371/Journal.Pone.0125614  0.594
2015 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 129: 929. PMID 25931052 DOI: 10.1007/S00401-015-1428-X  0.748
2015 Mitsui J, Matsukawa T, Sasaki H, Yabe I, Matsushima M, Dürr A, Brice A, Takashima H, Kikuchi A, Aoki M, Ishiura H, Yasuda T, Date H, Ahsan B, Iwata A, ... ... Trojanowski JQ, et al. Variants associated with Gaucher disease in multiple system atrophy. Annals of Clinical and Translational Neurology. 2: 417-26. PMID 25909086 DOI: 10.1002/Acn3.185  0.512
2015 Goossens J, Vanmechelen E, Trojanowski JQ, Lee VM, Van Broeckhoven C, van der Zee J, Engelborghs S. TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies. Acta Neuropathologica Communications. 3: 15. PMID 25853864 DOI: 10.1186/S40478-015-0195-1  0.478
2015 Haris M, Yadav SK, Rizwan A, Singh A, Cai K, Kaura D, Wang E, Davatzikos C, Trojanowski JQ, Melhem ER, Marincola FM, Borthakur A. T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease. Neuroimage. Clinical. 7: 598-604. PMID 25844314 DOI: 10.1016/J.Nicl.2015.02.016  0.359
2015 Toledo JB, Bjerke M, Da X, Landau SM, Foster NL, Jagust W, Jack C, Weiner M, Davatzikos C, Shaw LM, Trojanowski JQ. Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease. Jama Neurology. 72: 571-81. PMID 25822737 DOI: 10.1001/Jamaneurol.2014.4829  0.406
2015 Cornec AS, James MJ, Kovalevich J, Trojanowski JQ, Lee VM, Smith AB, Ballatore C, Brunden KR. Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine. Bioorganic & Medicinal Chemistry Letters. PMID 25819095 DOI: 10.1016/J.Bmcl.2015.03.002  0.456
2015 Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, ... ... Trojanowski JQ, et al. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathologica. 129: 757-62. PMID 25778618 DOI: 10.1007/S00401-015-1407-2  0.692
2015 Porta S, Kwong LK, Trojanowski JQ, Lee VM. Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases. Journal of Neuropathology and Experimental Neurology. 74: 380-7. PMID 25756586 DOI: 10.1097/Nen.0000000000000182  0.513
2015 Hu WT, Watts KD, Shaw LM, Howell JC, Trojanowski JQ, Basra S, Glass JD, Lah JJ, Levey AI. CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease? Annals of Clinical and Translational Neurology. 2: 131-9. PMID 25750918 DOI: 10.1002/Acn3.160  0.592
2015 Perry D, Sperling R, Katz R, Berry D, Dilts D, Hanna D, Salloway S, Trojanowski JQ, Bountra C, Krams M, Luthman J, Potkin S, Gribkoff V, Temple R, Wang Y, et al. Building a roadmap for developing combination therapies for Alzheimer's disease. Expert Review of Neurotherapeutics. 15: 327-33. PMID 25708309 DOI: 10.1586/14737175.2015.996551  0.374
2015 Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, ... ... Trojanowski JQ, et al. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science (New York, N.Y.). 347: 1436-41. PMID 25700176 DOI: 10.1126/Science.Aaa3650  0.444
2015 Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, et al. PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. Neurology. 84: 972-80. PMID 25663231 DOI: 10.1212/Wnl.0000000000001332  0.347
2015 Yu L, De Jager PL, Yang J, Trojanowski JQ, Bennett DA, Schneider JA. The TMEM106B locus and TDP-43 pathology in older persons without FTLD. Neurology. 84: 927-34. PMID 25653292 DOI: 10.1212/Wnl.0000000000001313  0.301
2015 Srivatsal S, Cholerton B, Leverenz JB, Wszolek ZK, Uitti RJ, Dickson DW, Weintraub D, Trojanowski JQ, Van Deerlin VM, Quinn JF, Chung KA, Peterson AL, Factor SA, Wood-Siverio C, Goldman JG, et al. Cognitive profile of LRRK2-related Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 728-33. PMID 25650144 DOI: 10.1002/Mds.26161  0.321
2015 Apostolova LG, Hwang KS, Avila D, Elashoff D, Kohannim O, Teng E, Sokolow S, Jack CR, Jagust WJ, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM. Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures. Neurology. 84: 729-37. PMID 25609767 DOI: 10.1212/Wnl.0000000000001231  0.373
2015 Brettschneider J, Del Tredici K, Lee VM, Trojanowski JQ. Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nature Reviews. Neuroscience. 16: 109-20. PMID 25588378 DOI: 10.1038/Nrn3887  0.528
2015 Cohen TJ, Hwang AW, Restrepo CR, Yuan CX, Trojanowski JQ, Lee VM. An acetylation switch controls TDP-43 function and aggregation propensity. Nature Communications. 6: 5845. PMID 25556531 DOI: 10.1038/Ncomms6845  0.483
2015 Irwin DJ, Cairns NJ, Grossman M, McMillan CT, Lee EB, Van Deerlin VM, Lee VM, Trojanowski JQ. Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine. Acta Neuropathologica. 129: 469-91. PMID 25549971 DOI: 10.1007/S00401-014-1380-1  0.813
2015 Teng E, Chow N, Hwang KS, Thompson PM, Gylys KH, Cole GM, Jack CR, Shaw LM, Trojanowski JQ, Soares HD, Weiner MW, Apostolova LG. Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dementia and Geriatric Cognitive Disorders. 39: 154-66. PMID 25547651 DOI: 10.1159/000368982  0.391
2015 Mattsson N, Insel PS, Donohue M, Landau S, Jagust WJ, Shaw LM, Trojanowski JQ, Zetterberg H, Blennow K, Weiner MW. Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease. Brain : a Journal of Neurology. 138: 772-83. PMID 25541191 DOI: 10.1093/Brain/Awu367  0.412
2015 Boluda S, Iba M, Zhang B, Raible KM, Lee VM, Trojanowski JQ. Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta Neuropathologica. 129: 221-37. PMID 25534024 DOI: 10.1007/S00401-014-1373-0  0.595
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Trojanowski JQ, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.702
2015 Kalia LV, Lang AE, Hazrati LN, Fujioka S, Wszolek ZK, Dickson DW, Ross OA, Van Deerlin VM, Trojanowski JQ, Hurtig HI, Alcalay RN, Marder KS, Clark LN, Gaig C, Tolosa E, et al. Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease. Jama Neurology. 72: 100-5. PMID 25401511 DOI: 10.1001/Jamaneurol.2014.2704  0.322
2015 Shinagawa S, Naasan G, Karydas AM, Coppola G, Pribadi M, Seeley WW, Trojanowski JQ, Miller BL, Grinberg LT. Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions. Journal of Geriatric Psychiatry and Neurology. 28: 99-107. PMID 25342578 DOI: 10.1177/0891988714554710  0.336
2015 O'Bryant SE, Gupta V, Henriksen K, Edwards M, Jeromin A, Lista S, Bazenet C, Soares H, Lovestone S, Hampel H, Montine T, Blennow K, Foroud T, Carrillo M, Graff-Radford N, ... ... Trojanowski JQ, et al. Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 549-60. PMID 25282381 DOI: 10.1016/J.Jalz.2014.08.099  0.37
2015 Swanson CR, Li K, Unger TL, Gallagher MD, Van Deerlin VM, Agarwal P, Leverenz J, Roberts J, Samii A, Gross RG, Hurtig H, Rick J, Weintraub D, Trojanowski JQ, Zabetian C, et al. Lower plasma apolipoprotein A1 levels are found in Parkinson's disease and associate with apolipoprotein A1 genotype. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 805-12. PMID 25227208 DOI: 10.1002/Mds.26022  0.783
2015 Peeraer E, Bottelbergs A, Van Kolen K, Stancu IC, Vasconcelos B, Mahieu M, Duytschaever H, Ver Donck L, Torremans A, Sluydts E, Van Acker N, Kemp JA, Mercken M, Brunden KR, Trojanowski JQ, et al. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of Disease. 73: 83-95. PMID 25220759 DOI: 10.1016/J.Jalz.2014.04.339  0.596
2015 Nosheny RL, Insel PS, Truran D, Schuff N, Jack CR, Aisen PS, Shaw LM, Trojanowski JQ, Weiner MW. Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment. Neurobiology of Aging. 36: 273-82. PMID 25175807 DOI: 10.1016/J.Neurobiolaging.2014.07.036  0.376
2015 Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, ... ... Trojanowski JQ, et al. At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 70-98. PMID 25022540 DOI: 10.1016/J.Jalz.2014.04.514  0.35
2015 Toledo JB, Zetterberg H, Van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, ... ... Trojanowski JQ, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects Brain. 138: 2701-2715. DOI: 10.1093/brain/awv199  0.561
2015 Fitts W, Weintraub D, Massimo L, Chahine L, Chen-Plotkin A, Duda JE, Hurtig HI, Rick J, Trojanowski JQ, Dahodwala N. Caregiver report of apathy predicts dementia in Parkinson's disease Parkinsonism and Related Disorders. DOI: 10.1016/j.parkreldis.2015.06.009  0.58
2015 Boeve B, Rosen HJ, Boxer AL, Dickerson B, Feldman H, Ghoshal N, Goldman J, Graff-Radford N, Grossman M, Robin Hsiung G, Huey ED, Irwin DJ, Jack CR, Kantarci K, Knopman DS, ... ... Trojanowski JQ, et al. O5-03-01: Longitudinal evaluation of familial frontotemporal dementia subjects (LEFFTDS): Subject characteristics, aims, and methodology Alzheimer's & Dementia. 11: P318-P319. DOI: 10.1016/J.Jalz.2015.07.457  0.432
2015 Kim S, Nho K, Risacher SL, Shen L, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ. Mapre2 as a novel Alzheimer's disease target gene from gwas of CSF amyloid beta 1-42, tau and hyperphosphorylated tau in the ADNI cohort Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.06.1712  0.44
2015 Nho K, Kim S, Risacher SL, Foroud TM, Aisen PS, Petersen RC, Jagust WJ, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW, Green RC, Toga AW, Greicius MD, Saykin AJ. IC-P-042: Influence of rare reelin variants on quantitative PET imaging and CSF phenotypes in late-onset Alzheimer's disease Alzheimer's & Dementia. 11: P36-P36. DOI: 10.1016/J.Jalz.2015.06.062  0.356
2015 Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NHH, Hsiung GYR, Hyman B, Iqbal K, Kaeser SA, Lachno DR, ... ... Trojanowski JQ, et al. Erratum: CSF biomarker variability in the Alzheimer's Association quality control program (Alzheimer's and Dementia (2013) 9 (251-261)) Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2014.12.004  0.384
2015 Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, ... ... Trojanowski JQ, et al. Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 1: 339-348. DOI: 10.1016/j.dadm.2015.06.008  0.658
2014 Kang JH, Ryoo NY, Shin DW, Trojanowski JQ, Shaw LM. Role of cerebrospinal fluid biomarkers in clinical trials for Alzheimer's disease modifying therapies. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology. 18: 447-56. PMID 25598657 DOI: 10.4196/Kjpp.2014.18.6.447  0.432
2014 Insel PS, Mattsson N, Donohue MC, Mackin RS, Aisen PS, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW. The transitional association between β-amyloid pathology and regional brain atrophy. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 25499535 DOI: 10.1016/J.Jalz.2014.11.002  0.426
2014 Toledo JB, Korff A, Shaw LM, Trojanowski JQ, Zhang J. Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment. Alzheimer's Research & Therapy. 6: 36. PMID 25478014 DOI: 10.1186/Alzrt266  0.433
2014 van Steenoven I, Aarsland D, Hurtig H, Chen-Plotkin A, Duda JE, Rick J, Chahine LM, Dahodwala N, Trojanowski JQ, Roalf DR, Moberg PJ, Weintraub D. Conversion between mini-mental state examination, montreal cognitive assessment, and dementia rating scale-2 scores in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1809-15. PMID 25381961 DOI: 10.1002/Mds.26062  0.568
2014 Mattsson N, Insel PS, Landau S, Jagust W, Donohue M, Shaw LM, Trojanowski JQ, Zetterberg H, Blennow K, Weiner M. Diagnostic accuracy of CSF Ab42 and florbetapir PET for Alzheimer's disease. Annals of Clinical and Translational Neurology. 1: 534-43. PMID 25356425 DOI: 10.1002/Acn3.81  0.377
2014 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathologica. 128: 755-66. PMID 25348064 DOI: 10.1007/S00401-014-1349-0  0.699
2014 Wang X, Liu L, Huang L, Herbst-Robinson K, Cornec AS, James MJ, Sugiyama S, Bassetto M, Brancale A, Trojanowski JQ, Lee VM, Smith AB, Brunden KR, Ballatore C. Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. Acs Medicinal Chemistry Letters. 5: 1015-20. PMID 25221659 DOI: 10.1021/Ml5002085  0.383
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Trojanowski JQ, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.722
2014 Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Kamboh MI, ... ... Trojanowski JQ, et al. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. Plos Genetics. 10: e1004606. PMID 25188341 DOI: 10.1371/Journal.Pgen.1004606  0.444
2014 Mata IF, Leverenz JB, Weintraub D, Trojanowski JQ, Hurtig HI, Van Deerlin VM, Ritz B, Rausch R, Rhodes SL, Factor SA, Wood-Siverio C, Quinn JF, Chung KA, Peterson AL, Espay AJ, et al. APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease. Jama Neurology. 71: 1405-12. PMID 25178429 DOI: 10.1001/Jamaneurol.2014.1455  0.311
2014 Ballatore C, Gay B, Huang L, Robinson KH, James MJ, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group. Bioorganic & Medicinal Chemistry Letters. 24: 4171-5. PMID 25127105 DOI: 10.1016/J.Bmcl.2014.07.047  0.378
2014 Yarchoan M, Toledo JB, Lee EB, Arvanitakis Z, Kazi H, Han LY, Louneva N, Lee VM, Kim SF, Trojanowski JQ, Arnold SE. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathologica. 128: 679-89. PMID 25107476 DOI: 10.1007/S00401-014-1328-5  0.708
2014 Burdick DJ, Cholerton B, Watson GS, Siderowf A, Trojanowski JQ, Weintraub D, Ritz B, Rhodes SL, Rausch R, Factor SA, Wood-Siverio C, Quinn JF, Chung KA, Srivatsal S, Edwards KL, et al. People with Parkinson's disease and normal MMSE score have a broad range of cognitive performance. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1258-64. PMID 25073717 DOI: 10.1002/Mds.25924  0.332
2014 Paterson RW, Bartlett JW, Blennow K, Fox NC, Shaw LM, Trojanowski JQ, Zetterberg H, Schott JM. Cerebrospinal fluid markers including trefoil factor 3 are associated with neurodegeneration in amyloid-positive individuals. Translational Psychiatry. 4: e419. PMID 25072324 DOI: 10.1038/Tp.2014.58  0.427
2014 Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain : a Journal of Neurology. 137: 2578-87. PMID 25012223 DOI: 10.1093/Brain/Awu190  0.678
2014 Irwin DJ, McMillan CT, Suh E, Powers J, Rascovsky K, Wood EM, Toledo JB, Arnold SE, Lee VM, Van Deerlin VM, Trojanowski JQ, Grossman M. Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia. Neurology. 83: 502-9. PMID 24994843 DOI: 10.1212/Wnl.0000000000000668  0.731
2014 Lou K, Yao Y, Hoye AT, James MJ, Cornec AS, Hyde E, Gay B, Lee VM, Trojanowski JQ, Smith AB, Brunden KR, Ballatore C. Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies. Journal of Medicinal Chemistry. 57: 6116-27. PMID 24992153 DOI: 10.1021/Jm5005623  0.51
2014 Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, ... ... Trojanowski JQ, et al. Frontotemporal dementia and its subtypes: a genome-wide association study. The Lancet. Neurology. 13: 686-99. PMID 24943344 DOI: 10.1016/S1474-4422(14)70065-1  0.669
2014 Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM. Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration. Cell Reports. 7: 2054-65. PMID 24931606 DOI: 10.1016/J.Celrep.2014.05.033  0.536
2014 Weiner MW, Veitch DP, Hayes J, Neylan T, Grafman J, Aisen PS, Petersen RC, Jack C, Jagust W, Trojanowski JQ, Shaw LM, Saykin AJ, Green RC, Harvey D, Toga AW, et al. Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S226-35. PMID 24924673 DOI: 10.1016/J.Jalz.2014.04.005  0.358
2014 Boluda S, Toledo JB, Irwin DJ, Raible KM, Byrne MD, Lee EB, Lee VM, Trojanowski JQ. A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis. Acta Neuropathologica. 128: 543-50. PMID 24916271 DOI: 10.1007/S00401-014-1308-9  0.756
2014 Brettschneider J, Arai K, Del Tredici K, Toledo JB, Robinson JL, Lee EB, Kuwabara S, Shibuya K, Irwin DJ, Fang L, Van Deerlin VM, Elman L, McCluskey L, Ludolph AC, Lee VM, ... ... Trojanowski JQ, et al. TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathologica. 128: 423-37. PMID 24916269 DOI: 10.1007/S00401-014-1299-6  0.72
2014 McCluskey LF, Geser F, Elman LB, Van Deerlin VM, Robinson JL, Lee VM, Trojanowski JQ. Atypical Alzheimer's disease in an elderly United States resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 15: 466-72. PMID 24809433 DOI: 10.3109/21678421.2014.903973  0.598
2014 Walker AK, Daniels CM, Goldman JE, Trojanowski JQ, Lee VM, Messing A. Astrocytic TDP-43 pathology in Alexander disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6448-58. PMID 24806671 DOI: 10.1523/Jneurosci.0248-14.2014  0.688
2014 Mattsson N, Insel PS, Nosheny R, Tosun D, Trojanowski JQ, Shaw LM, Jack CR, Donohue MC, Weiner MW. Emerging β-amyloid pathology and accelerated cortical atrophy. Jama Neurology. 71: 725-34. PMID 24781145 DOI: 10.1001/Jamaneurol.2014.446  0.418
2014 Leinonen V, Rinne JO, Wong DF, Wolk DA, Trojanowski JQ, Sherwin PF, Smith A, Heurling K, Su M, Grachev ID. Diagnostic effectiveness of quantitative [¹⁸F]flutemetamol PET imaging for detection of fibrillar amyloid β using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus. Acta Neuropathologica Communications. 2: 46. PMID 24755237 DOI: 10.1186/2051-5960-2-46  0.359
2014 Bit-Ivan EN, Suh E, Shim HS, Weintraub S, Hyman BT, Arnold SE, McCarty-Wood E, Van Deerlin VM, Schneider JA, Trojanowski JQ, Frosch MP, Baker MC, Rademakers R, Mesulam M, Bigio EH. A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases. Journal of Neuropathology and Experimental Neurology. 73: 467-73. PMID 24709683 DOI: 10.1097/Nen.0000000000000070  0.528
2014 Kwong LK, Irwin DJ, Walker AK, Xu Y, Riddle DM, Trojanowski JQ, Lee VM. Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins. Acta Neuropathologica Communications. 2: 33. PMID 24690345 DOI: 10.1186/2051-5960-2-33  0.635
2014 McMillan CT, Avants BB, Cook P, Ungar L, Trojanowski JQ, Grossman M. The power of neuroimaging biomarkers for screening frontotemporal dementia. Human Brain Mapping. 35: 4827-40. PMID 24687814 DOI: 10.1002/Hbm.22515  0.666
2014 Apostolova LG, Hwang KS, Kohannim O, Avila D, Elashoff D, Jack CR, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM. ApoE4 effects on automated diagnostic classifiers for mild cognitive impairment and Alzheimer's disease. Neuroimage. Clinical. 4: 461-72. PMID 24634832 DOI: 10.1016/J.Nicl.2013.12.012  0.428
2014 Korecka M, Waligorska T, Figurski M, Toledo JB, Arnold SE, Grossman M, Trojanowski JQ, Shaw LM. Qualification of a surrogate matrix-based absolute quantification method for amyloid-β₄₂ in human cerebrospinal fluid using 2D UPLC-tandem mass spectrometry. Journal of Alzheimer's Disease : Jad. 41: 441-51. PMID 24625802 DOI: 10.3233/Jad-132489  0.462
2014 Toledo JB, Weiner MW, Wolk DA, Da X, Chen K, Arnold SE, Jagust W, Jack C, Reiman EM, Davatzikos C, Shaw LM, Trojanowski JQ. Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition. Acta Neuropathologica Communications. 2: 26. PMID 24602322 DOI: 10.1186/2051-5960-2-26  0.383
2014 Nuytemans K, Inchausti V, Beecham GW, Wang L, Dickson DW, Trojanowski JQ, Lee VM, Mash DC, Frosch MP, Foroud TM, Honig LS, Montine TJ, Dawson TM, Martin ER, Scott WK, et al. Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 827-30. PMID 24573903 DOI: 10.1002/Mds.25838  0.511
2014 Hughes ME, Peeler J, Hogenesch JB, Trojanowski JQ. The growth and impact of Alzheimer disease centers as measured by social network analysis. Jama Neurology. 71: 412-20. PMID 24514750 DOI: 10.1001/Jamaneurol.2013.6225  0.376
2014 Grossman M, Elman L, McCluskey L, McMillan CT, Boller A, Powers J, Rascovsky K, Hu W, Shaw L, Irwin DJ, Lee VM, Trojanowski JQ. Phosphorylated tau as a candidate biomarker for amyotrophic lateral sclerosis. Jama Neurology. 71: 442-8. PMID 24492862 DOI: 10.1001/Jamaneurol.2013.6064  0.774
2014 Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, ... ... Trojanowski JQ, et al. TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathologica. 127: 407-18. PMID 24442578 DOI: 10.1007/S00401-013-1239-X  0.798
2014 Brunden KR, Trojanowski JQ, Smith AB, Lee VM, Ballatore C. Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease. Bioorganic & Medicinal Chemistry. 22: 5040-9. PMID 24433963 DOI: 10.1016/J.Bmc.2013.12.046  0.533
2014 Sondheimer N, Zollo O, Van Deerlin V, Trojanowski JQ. Analysis of cerebrospinal fluid mitochondrial DNA levels in Alzheimer disease. Annals of Neurology. 75: 458-60. PMID 24424574 DOI: 10.1002/Ana.24107  0.336
2014 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 127: 423-39. PMID 24407427 DOI: 10.1007/S00401-013-1238-Y  0.754
2014 Ballatore C, Smith AB, Lee VM, Trojanowski JQ, Brunden KR. Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497. Expert Opinion On Therapeutic Patents. 24: 355-60. PMID 24387030 DOI: 10.1517/13543776.2014.871526  0.513
2014 Toledo JB, Da X, Weiner MW, Wolk DA, Xie SX, Arnold SE, Davatzikos C, Shaw LM, Trojanowski JQ. CSF Apo-E levels associate with cognitive decline and MRI changes. Acta Neuropathologica. 127: 621-32. PMID 24385135 DOI: 10.1007/S00401-013-1236-0  0.378
2014 McMillan CT, Toledo JB, Avants BB, Cook PA, Wood EM, Suh E, Irwin DJ, Powers J, Olm C, Elman L, McCluskey L, Schellenberg GD, Lee VM, Trojanowski JQ, Van Deerlin VM, et al. Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration. Neurobiology of Aging. 35: 1473-82. PMID 24373676 DOI: 10.1016/J.Neurobiolaging.2013.11.029  0.739
2014 Da X, Toledo JB, Zee J, Wolk DA, Xie SX, Ou Y, Shacklett A, Parmpi P, Shaw L, Trojanowski JQ, Davatzikos C. Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers. Neuroimage. Clinical. 4: 164-73. PMID 24371799 DOI: 10.1016/J.Nicl.2013.11.010  0.414
2014 Johnston JM, Hu WT, Fardo DW, Greco SJ, Perry G, Montine TJ, Trojanowski JQ, Shaw LM, Ashford JW, Tezapsidis N. Low plasma leptin in cognitively impaired ADNI subjects: gender differences and diagnostic and therapeutic potential. Current Alzheimer Research. 11: 165-74. PMID 24359504 DOI: 10.2174/1567205010666131212114156  0.575
2014 Sánchez-Juan P, Ghosh PM, Hagen J, Gesierich B, Henry M, Grinberg LT, O'Neil JP, Janabi M, Huang EJ, Trojanowski JQ, Vinters HV, Gorno-Tempini M, Seeley WW, Boxer AL, Rosen HJ, et al. Practical utility of amyloid and FDG-PET in an academic dementia center. Neurology. 82: 230-8. PMID 24353340 DOI: 10.1212/Wnl.0000000000000032  0.313
2014 Caso F, Mandelli ML, Henry M, Gesierich B, Bettcher BM, Ogar J, Filippi M, Comi G, Magnani G, Sidhu M, Trojanowski JQ, Huang EJ, Grinberg LT, Miller BL, Dronkers N, et al. In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology. Neurology. 82: 239-47. PMID 24353332 DOI: 10.1212/Wnl.0000000000000031  0.396
2014 Kim HJ, Raphael AR, LaDow ES, McGurk L, Weber RA, Trojanowski JQ, Lee VM, Finkbeiner S, Gitler AD, Bonini NM. Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nature Genetics. 46: 152-60. PMID 24336168 DOI: 10.1038/Ng.2853  0.486
2014 Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack CR, Tosun D, Weiner M. Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults. Neurobiology of Aging. 35: 614-22. PMID 24094581 DOI: 10.1016/J.Neurobiolaging.2013.08.027  0.428
2014 Toledo JB, Van Deerlin VM, Lee EB, Suh E, Baek Y, Robinson JL, Xie SX, McBride J, Wood EM, Schuck T, Irwin DJ, Gross RG, Hurtig H, McCluskey L, Elman L, ... ... Trojanowski JQ, et al. A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 477-84.e1. PMID 23978324 DOI: 10.1016/J.Jalz.2013.06.003  0.801
2014 Henriksen K, O'Bryant SE, Hampel H, Trojanowski JQ, Montine TJ, Jeromin A, Blennow K, Lönneborg A, Wyss-Coray T, Soares H, Bazenet C, Sjögren M, Hu W, Lovestone S, Karsdal MA, et al. The future of blood-based biomarkers for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 115-31. PMID 23850333 DOI: 10.1016/J.Jalz.2013.01.013  0.606
2014 Swaminathan S, Risacher SL, Yoder KK, West JD, Shen L, Kim S, Inlow M, Foroud T, Jagust WJ, Koeppe RA, Mathis CA, Shaw LM, Trojanowski JQ, Soares H, Aisen PS, et al. Association of plasma and cortical amyloid beta is modulated by APOE ε4 status. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: e9-e18. PMID 23541187 DOI: 10.1016/J.Jalz.2013.01.007  0.306
2014 Irwin D, Lee V, Trojanowski J. Parkinson's disease dementia: at the crossroads of α-synuclein, tau and amyloid-β Neurobiology of Aging. 35: S11. DOI: 10.1016/J.Neurobiolaging.2014.01.070  0.402
2014 Tsuang D, Bekris L, Leverenz J, Yu C, Lopez O, Hamilton R, Bennett D, Schneider J, Buchman A, Larson EB, Crane P, Kaye J, Kramer P, Woltjer R, Trojanowski JQ, et al. P4-377: A TOMM40 SNP IN APOE E4 NON-CARRIERS INCREASES RISK FOR MULTIPLE TYPES OF DEMENTIA Alzheimer's & Dementia. 10: P926-P926. DOI: 10.1016/J.Jalz.2014.07.146  0.68
2014 Mattsson N, Insel P, Landau S, Jagust W, Shaw L, Trojanowski JQ, Zetterberg H, Blennow K, Weiner MW. P2-094: COMPARING THE DIAGNOSTIC ACCURACIES OF CSF Aβ42 AND PET FLORBETAPIR Alzheimer's & Dementia. 10: P505-P505. DOI: 10.1016/J.Jalz.2014.05.768  0.311
2014 Dean R, Shaw LM, Waligorska TW, Korecka M, Figurski M, Trojanowski JQ, Sundell K, Andersen SW, Holdridge K, Lachno DR, Talbot J, Siemers E. INCLUSION OF PATIENTS WITH ALZHEIMER'S DISEASE PATHOLOGY IN SOLANEZUMAB EXPEDITION 3 USING FLORBETAPIR PET IMAGING OR INNO-BIA ALZBIO3 CSF Aβ1-42 Alzheimers & Dementia. 10: 811. DOI: 10.1016/J.Jalz.2014.05.1591  0.41
2014 Ramanan VK, Nho K, Risacher SL, Kim S, Shen L, Swaminathan S, Foroud TM, Aisen P, Hakonarson H, Huentelman M, Jack C, Jagust W, Petersen RC, Potkin S, Shaw L, ... Trojanowski JQ, et al. P3-024: NEXT-GENERATION SEQUENCING OF THE BCHE LOCUS IDENTIFIES A FUNCTIONAL SNP ASSOCIATED WITH ALZHEIMER'S DISEASE BIOMARKERS AND AGE OF ONSET Alzheimer's & Dementia. 10: P636-P636. DOI: 10.1016/J.Jalz.2014.05.1111  0.402
2014 Nho KT, Kim S, Risacher SL, Shen L, Foroud T, Aisen P, Petersen R, Jack C, Shaw L, Trojanowski JQ, Weiner MW, Green R, Toga A, Saykin AJ. P3-018: INFLUENCE OF RARE PSEN1 VARIANTS ON QUANTITATIVE STRUCTURAL IMAGING AND CSF PHENOTYPES IN LATE ONSET ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P633-P633. DOI: 10.1016/J.Jalz.2014.05.1105  0.383
2014 Nho KT, Kim S, Risacher SL, Shen L, Foroud T, Shaw L, Trojanowski JQ, Aisen P, Petersen R, Jack C, Weiner MW, Green R, Toga A, Saykin AJ. P3-017: ASSOCIATION ANALYSIS OF RARE VARIANTS NEAR THE APOE REGION WITH CEREBROSPINAL FLUID (CSF) BIOMARKERS OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P632-P633. DOI: 10.1016/J.Jalz.2014.05.1104  0.405
2014 Mattsson N, Insel P, Landau S, Jagust W, Shaw L, Trojanowski JQ, Zetterberg H, Blennow K, Weiner MW. O2-05-06: COMBINING CSF AB42 AND PET FLORBETAPIR TO PREDICT DIAGNOSIS, TAU, ATROPHY, AND COGNITION Alzheimer's & Dementia. 10: P174-P174. DOI: 10.1016/J.Jalz.2014.04.185  0.303
2014 Roy S, Irwin DJ, Lee VMY, Trojanowski JQ. Axonal Transport and Neurodegenerative Diseases Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.04517-7  0.599
2013 Brunden KR, Gardner NM, James MJ, Yao Y, Trojanowski JQ, Lee VM, Paterson I, Ballatore C, Smith AB. MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. Acs Medicinal Chemistry Letters. 4: 886-9. PMID 24900764 DOI: 10.1021/Ml400233E  0.523
2013 Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VM, Trojanowski JQ, Chen-Plotkin AS. Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain. Acta Neuropathologica Communications. 1: 36. PMID 24252750 DOI: 10.1186/2051-5960-1-36  0.808
2013 Stutzbach LD, Xie SX, Naj AC, Albin R, Gilman S, Lee VM, Trojanowski JQ, Devlin B, Schellenberg GD. The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. Acta Neuropathologica Communications. 1: 31. PMID 24252572 DOI: 10.1186/2051-5960-1-31  0.578
2013 Toledo JB, Cairns NJ, Da X, Chen K, Carter D, Fleisher A, Householder E, Ayutyanont N, Roontiva A, Bauer RJ, Eisen P, Shaw LM, Davatzikos C, Weiner MW, Reiman EM, ... ... Trojanowski JQ, et al. Clinical and multimodal biomarker correlates of ADNI neuropathological findings. Acta Neuropathologica Communications. 1: 65. PMID 24252435 DOI: 10.1186/2051-5960-1-65  0.467
2013 Motsinger-Reif AA, Zhu H, Kling MA, Matson W, Sharma S, Fiehn O, Reif DM, Appleby DH, Doraiswamy PM, Trojanowski JQ, Kaddurah-Daouk R, Arnold SE. Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging. Acta Neuropathologica Communications. 1: 28. PMID 24252434 DOI: 10.1186/2051-5960-1-28  0.423
2013 Braak H, Brettschneider J, Ludolph AC, Lee VM, Trojanowski JQ, Del Tredici K. Amyotrophic lateral sclerosis--a model of corticofugal axonal spread. Nature Reviews. Neurology. 9: 708-14. PMID 24217521 DOI: 10.1038/Nrneurol.2013.221  0.495
2013 Hu WT, Watts K, Grossman M, Glass J, Lah JJ, Hales C, Shelnutt M, Van Deerlin V, Trojanowski JQ, Levey AI. Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP. Neurology. 81: 1945-52. PMID 24174584 DOI: 10.1212/01.Wnl.0000436625.63650.27  0.675
2013 Hu WT, Shaw LM, Trojanowski JQ. Alzheimer's disease biomarkers: walk with deliberate haste, don't run blithely on? Acta Neuropathologica. 126: 625-9. PMID 24154963 DOI: 10.1007/S00401-013-1197-3  0.581
2013 Wilson RS, Yu L, Trojanowski JQ, Chen EY, Boyle PA, Bennett DA, Schneider JA. TDP-43 pathology, cognitive decline, and dementia in old age. Jama Neurology. 70: 1418-24. PMID 24080705 DOI: 10.1001/Jamaneurol.2013.3961  0.366
2013 Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 79: 1094-108. PMID 24050400 DOI: 10.1016/J.Neuron.2013.07.037  0.558
2013 Lee EB, Russ J, Jung H, Elman LB, Chahine LM, Kremens D, Miller BL, Branch Coslett H, Trojanowski JQ, Van Deerlin VM, McCluskey LF. Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U. Acta Neuropathologica Communications. 1: 1-11. PMID 24027631 DOI: 10.1186/2051-5960-1-9  0.648
2013 Kang JH, Irwin DJ, Chen-Plotkin AS, Siderowf A, Caspell C, Coffey CS, Waligórska T, Taylor P, Pan S, Frasier M, Marek K, Kieburtz K, Jennings D, Simuni T, Tanner CM, ... ... Trojanowski JQ, et al. Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease. Jama Neurology. 70: 1277-87. PMID 23979011 DOI: 10.1001/Jamaneurol.2013.3861  0.721
2013 Yarchoan M, Louneva N, Xie SX, Swenson FJ, Hu W, Soares H, Trojanowski JQ, Lee VM, Kling MA, Shaw LM, Chen-Plotkin A, Wolk DA, Arnold SE. Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease. Journal of the Neurological Sciences. 333: 9-12. PMID 23978419 DOI: 10.1016/J.Jns.2013.05.028  0.74
2013 Mattsson N, Insel P, Nosheny R, Zetterberg H, Trojanowski JQ, Shaw LM, Tosun D, Weiner M. CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy elders. Translational Psychiatry. 3: e293. PMID 23962923 DOI: 10.1038/Tp.2013.69  0.368
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