| Year |
Citation |
Score |
| 2023 |
Flagg MP, Lam B, Lam DK, Le TM, Kao A, Slaiwa YI, Hampton RY. Exploring the "misfolding problem" by systematic discovery and analysis of functional-but-degraded proteins. Molecular Biology of the Cell. 34: ar125. PMID 37729018 DOI: 10.1091/mbc.E23-06-0248 |
0.361 |
|
| 2021 |
Flagg MP, Wangeline MA, Holland SR, Duttke SH, Benner C, Neal S, Hampton RY. Inner-Nuclear-Membrane-Associated Degradation Employs Dfm1-Independent Retrotranslocation and Alleviates Misfolded Transmembrane-Protein Toxicity. Molecular Biology of the Cell. mbcE20110720. PMID 33566711 DOI: 10.1091/mbc.E20-11-0720 |
0.444 |
|
| 2020 |
Wangeline MA, Hampton RY. An autonomous, but INSIG-modulated, role for the Sterol Sensing Domain in mallostery-regulated ERAD of yeast HMG-CoA reductase. The Journal of Biological Chemistry. PMID 33184059 DOI: 10.1074/jbc.RA120.015910 |
0.46 |
|
| 2020 |
Singh A, Vashistha N, Heck J, Tang X, Wipf P, Brodsky JL, Hampton RY. Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control. Molecular Biology of the Cell. mbcE20080541. PMID 32966159 DOI: 10.1091/mbc.E20-08-0541 |
0.824 |
|
| 2020 |
Neal S, Syau D, Nejatfard A, Nadeau S, Hampton RY. HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation. Iscience. 23: 101493. PMID 32891886 DOI: 10.1016/J.Isci.2020.101493 |
0.541 |
|
| 2019 |
Neal S, Duttke SH, Hampton RY. Assays for protein retrotranslocation in ERAD. Methods in Enzymology. 619: 1-26. PMID 30910017 DOI: 10.1016/Bs.Mie.2019.01.002 |
0.569 |
|
| 2018 |
Wangeline MA, Hampton RY. "Mallostery"-ligand-dependent protein misfolding enables physiological regulation by ERAD. The Journal of Biological Chemistry. PMID 30018140 DOI: 10.1074/Jbc.Ra118.001808 |
0.536 |
|
| 2018 |
Jaeger PA, Ornelas L, McElfresh C, Wong LR, Hampton RY, Ideker T. Systematic Gene-to-Phenotype Arrays: A High-Throughput Technique for Molecular Phenotyping. Molecular Cell. 69: 321-333.e3. PMID 29351850 DOI: 10.1016/J.Molcel.2017.12.016 |
0.391 |
|
| 2018 |
Neal S, Jaeger PA, Duttke SH, Benner CK, Glass C, Ideker T, Hampton R. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Molecular Cell. 69: 306-320.e4. PMID 29351849 DOI: 10.1016/J.Molcel.2017.12.012 |
0.502 |
|
| 2017 |
Wangeline MA, Vashistha N, Hampton RY. Proteostatic Tactics in the Strategy of Sterol Regulation. Annual Review of Cell and Developmental Biology. 33: 467-489. PMID 28992438 DOI: 10.1146/Annurev-Cellbio-111315-125036 |
0.522 |
|
| 2017 |
Hampton RY, Dargemont C. New developments for protein quality control. Science (New York, N.Y.). 357: 450-451. PMID 28774913 DOI: 10.1126/Science.Aao1896 |
0.472 |
|
| 2017 |
Neal SE, Mak R, Bennett EJ, Hampton R. A "Retrochaperone" Function for Cdc48: the Cdc48 Complex is Required for Retrotranslocated ERAD-M Substrate Solubility. The Journal of Biological Chemistry. PMID 28077573 DOI: 10.1074/Jbc.M116.770610 |
0.438 |
|
| 2016 |
Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, et al. Control of the innate immune response by the mevalonate pathway. Nature Immunology. PMID 27270400 DOI: 10.1038/Ni.3487 |
0.396 |
|
| 2016 |
Vashistha N, Neal SE, Singh A, Carroll SM, Hampton RY. Direct and essential function for Hrd3 in ER-associated degradation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27170191 DOI: 10.1073/Pnas.1603079113 |
0.716 |
|
| 2015 |
Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, et al. The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Molecular Cell. 59: 35-49. PMID 26051182 DOI: 10.1016/J.Molcel.2015.04.026 |
0.554 |
|
| 2013 |
Theesfeld CL, Hampton RY. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. The Journal of Biological Chemistry. 288: 8519-30. PMID 23306196 DOI: 10.1074/Jbc.M112.404517 |
0.528 |
|
| 2012 |
Hampton RY, Sommer T. Finding the will and the way of ERAD substrate retrotranslocation. Current Opinion in Cell Biology. 24: 460-6. PMID 22854296 DOI: 10.1016/J.Ceb.2012.05.010 |
0.558 |
|
| 2012 |
Li S, Spooner RA, Hampton RY, Lord JM, Roberts LM. Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p. Plos One. 7: e41119. PMID 22829918 DOI: 10.1371/Journal.Pone.0041119 |
0.423 |
|
| 2011 |
Theesfeld CL, Pourmand D, Davis T, Garza RM, Hampton RY. The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. The Journal of Biological Chemistry. 286: 26298-307. PMID 21628456 DOI: 10.1074/Jbc.M111.244798 |
0.813 |
|
| 2011 |
Hampton RY. San1-mediated quality control: substrate recognition "sans" chaperones. Molecular Cell. 41: 2-3. PMID 21211716 DOI: 10.1016/J.Molcel.2010.12.022 |
0.399 |
|
| 2010 |
Heck JW, Cheung SK, Hampton RY. Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proceedings of the National Academy of Sciences of the United States of America. 107: 1106-11. PMID 20080635 DOI: 10.1073/Pnas.0910591107 |
0.834 |
|
| 2010 |
Carroll SM, Hampton RY. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. The Journal of Biological Chemistry. 285: 5146-56. PMID 19940128 DOI: 10.1074/Jbc.M109.067876 |
0.712 |
|
| 2009 |
Garza RM, Tran PN, Hampton RY. Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. The Journal of Biological Chemistry. 284: 35368-80. PMID 19776008 DOI: 10.1074/Jbc.M109.023994 |
0.777 |
|
| 2009 |
Sato BK, Schulz D, Do PH, Hampton RY. Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Molecular Cell. 34: 212-22. PMID 19394298 DOI: 10.1016/J.Molcel.2009.03.010 |
0.768 |
|
| 2009 |
Garza RM, Sato BK, Hampton RY. In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. The Journal of Biological Chemistry. 284: 14710-22. PMID 19324879 DOI: 10.1074/Jbc.M809607200 |
0.836 |
|
| 2009 |
Hampton RY, Garza RM. Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway. Chemical Reviews. 109: 1561-74. PMID 19243134 DOI: 10.1021/Cr800544V |
0.811 |
|
| 2008 |
Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY. Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Molecular Biology of the Cell. 19: 4506-20. PMID 18667535 DOI: 10.1091/Mbc.E07-11-1188 |
0.798 |
|
| 2008 |
Bazirgan OA, Hampton RY. Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. The Journal of Biological Chemistry. 283: 12797-810. PMID 18321851 DOI: 10.1074/Jbc.M801122200 |
0.81 |
|
| 2007 |
Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. The Journal of Biological Chemistry. 282: 33776-87. PMID 17893151 DOI: 10.1074/Jbc.M703320200 |
0.788 |
|
| 2006 |
Sato BK, Hampton RY. Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Yeast (Chichester, England). 23: 1053-64. PMID 17083136 DOI: 10.1002/Yea.1407 |
0.768 |
|
| 2006 |
Bazirgan OA, Garza RM, Hampton RY. Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase. The Journal of Biological Chemistry. 281: 38989-9001. PMID 17035235 DOI: 10.1074/Jbc.M608174200 |
0.789 |
|
| 2005 |
Hampton RY. Fusion-based strategies to identify genes involved in degradation of a specific substrate. Methods in Enzymology. 399: 310-23. PMID 16338365 DOI: 10.1016/S0076-6879(05)99021-6 |
0.417 |
|
| 2005 |
Flury I, Garza R, Shearer A, Rosen J, Cronin S, Hampton RY. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. The Embo Journal. 24: 3917-26. PMID 16270032 DOI: 10.1038/Sj.Emboj.7600855 |
0.813 |
|
| 2005 |
Federovitch CM, Ron D, Hampton RY. The dynamic ER: experimental approaches and current questions. Current Opinion in Cell Biology. 17: 409-14. PMID 15975777 DOI: 10.1016/J.Ceb.2005.06.010 |
0.769 |
|
| 2005 |
Garza RM, Hampton RY. Cell biology: sterol sensor comes up for air. Nature. 435: 37-8. PMID 15875007 DOI: 10.1038/435037A |
0.698 |
|
| 2005 |
Bazirgan OA, Hampton RY. Cdc48-Ufd2-Rad23: the road less ubiquitinated? Nature Cell Biology. 7: 207-9. PMID 15738968 DOI: 10.1038/Ncb0305-207 |
0.779 |
|
| 2005 |
Shearer AG, Hampton RY. Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. The Embo Journal. 24: 149-59. PMID 15635451 DOI: 10.1038/Sj.Emboj.7600498 |
0.794 |
|
| 2004 |
Ron D, Hampton RY. Membrane biogenesis and the unfolded protein response. The Journal of Cell Biology. 167: 23-5. PMID 15479733 DOI: 10.1083/Jcb.200408117 |
0.505 |
|
| 2004 |
Shearer AG, Hampton RY. Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase. The Journal of Biological Chemistry. 279: 188-96. PMID 14570925 DOI: 10.1074/Jbc.M307734200 |
0.807 |
|
| 2003 |
Hampton RY. IRE1: a role in UPREgulation of ER degradation. Developmental Cell. 4: 144-6. PMID 12586055 DOI: 10.1016/S1534-5807(03)00032-7 |
0.499 |
|
| 2002 |
Hampton RY. ER-associated degradation in protein quality control and cellular regulation. Current Opinion in Cell Biology. 14: 476-82. PMID 12383799 DOI: 10.1016/S0955-0674(02)00358-7 |
0.565 |
|
| 2002 |
Hampton RY. Proteolysis and sterol regulation. Annual Review of Cell and Developmental Biology. 18: 345-78. PMID 12142284 DOI: 10.1146/Annurev.Cellbio.18.032002.131219 |
0.48 |
|
| 2002 |
Cronin SR, Rao R, Hampton RY. Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. The Journal of Cell Biology. 157: 1017-28. PMID 12058017 DOI: 10.1083/Jcb.200203052 |
0.803 |
|
| 2002 |
Bays NW, Hampton RY. Cdc48-Ufd1-Npl4: stuck in the middle with Ub. Current Biology : Cb. 12: R366-71. PMID 12015140 DOI: 10.1016/S0960-9822(02)00862-X |
0.822 |
|
| 2001 |
Bays NW, Wilhovsky SK, Goradia A, Hodgkiss-Harlow K, Hampton RY. HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Molecular Biology of the Cell. 12: 4114-28. PMID 11739805 DOI: 10.1091/Mbc.12.12.4114 |
0.818 |
|
| 2001 |
Gardner RG, Shearer AG, Hampton RY. In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Molecular and Cellular Biology. 21: 4276-91. PMID 11390656 DOI: 10.1128/Mcb.21.13.4276-4291.2001 |
0.814 |
|
| 2001 |
Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nature Cell Biology. 3: 24-9. PMID 11146622 DOI: 10.1038/35050524 |
0.838 |
|
| 2001 |
Gardner RG, Shan H, Matsuda SPT, Hampton RY. An Oxysterol-derived Positive Signal for 3-Hydroxy-3-methylglutaryl-CoA Reductase Degradation in Yeast Journal of Biological Chemistry. 276: 8681-8694. PMID 11134013 DOI: 10.1074/Jbc.M007888200 |
0.39 |
|
| 2000 |
Gardner RG, Swarbrick GM, Bays NW, Cronin SR, Wilhovsky S, Seelig L, Kim C, Hampton RY. Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. The Journal of Cell Biology. 151: 69-82. PMID 11018054 DOI: 10.1083/Jcb.151.1.69 |
0.813 |
|
| 2000 |
Hampton RY. ER stress response: Getting the UPR hand on misfolded proteins Current Biology. 10. PMID 10898996 DOI: 10.1016/S0960-9822(00)00583-2 |
0.525 |
|
| 2000 |
Hampton RY. Cholesterol homeostasis: ESCAPe from the ER Current Biology. 10. PMID 10801406 DOI: 10.1016/S0960-9822(00)00434-6 |
0.374 |
|
| 2000 |
Wilhovsky S, Gardner R, Hampton R. HRD gene dependence of endoplasmic reticulum-associated degradation. Molecular Biology of the Cell. 11: 1697-708. PMID 10793145 DOI: 10.1091/Mbc.11.5.1697 |
0.579 |
|
| 2000 |
Cronin SR, Khoury A, Ferry DK, Hampton RY. Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. The Journal of Cell Biology. 148: 915-24. PMID 10704442 DOI: 10.1083/Jcb.148.5.915 |
0.806 |
|
| 1999 |
Cronin SR, Hampton RY. Measuring protein degradation with green fluorescent protein. Methods in Enzymology. 302: 58-73. PMID 12876763 DOI: 10.1016/S0076-6879(99)02010-8 |
0.813 |
|
| 1999 |
Gardner RG, Hampton RY. A 'distributed degron' allows regulated entry into the ER degradation pathway Embo Journal. 18: 5994-6004. PMID 10545111 DOI: 10.1093/Emboj/18.21.5994 |
0.577 |
|
| 1999 |
Gardner RG, Hampton RY. A highly conserved signal controls degradation of 3-hydroxy-3- methylglutaryl-coenzyme a (HMG-CoA) reductase in eukaryotes Journal of Biological Chemistry. 274: 31671-31678. PMID 10531376 DOI: 10.1074/Jbc.274.44.31671 |
0.411 |
|
| 1999 |
Cronin S, Hampton R. Techniques update Trends in Cell Biology. 9: 36. DOI: 10.1016/S0962-8924(98)01421-4 |
0.753 |
|
| 1998 |
Gardner R, Cronin S, Leader B, Rine J, Hampton R. Sequence Determinants for Regulated Degradation of Yeast 3-Hydroxy-3-Methylglutaryl-CoA Reductase, an Integral Endoplasmic Reticulum Membrane Protein Molecular Biology of the Cell. 9: 2611-2626. PMID 9725915 DOI: 10.1091/Mbc.9.9.2611 |
0.795 |
|
| 1998 |
Hampton RY. Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation Current Opinion in Lipidology. 9: 93-97. PMID 9559264 DOI: 10.1097/00041433-199804000-00003 |
0.441 |
|
| 1997 |
Hampton RY, Bhakta H. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase Proceedings of the National Academy of Sciences of the United States of America. 94: 12944-12948. PMID 9371780 DOI: 10.1073/Pnas.94.24.12944 |
0.499 |
|
| 1997 |
Donald KAG, Hampton RY, Fritz IB. Effects of overproduction of the catalytic domain of 3-hydroxy-3- methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae Applied and Environmental Microbiology. 63: 3341-3344. PMID 9292983 DOI: 10.1128/Aem.63.9.3341-3344.1997 |
0.346 |
|
| 1996 |
Hampton RY, Gardner RG, Rine J. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3- methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein Molecular Biology of the Cell. 7: 2029-2044. PMID 8970163 DOI: 10.1091/Mbc.7.12.2029 |
0.532 |
|
| 1996 |
Hampton RY, Koning A, Wright R, Rine J. In vivo examination of membrane protein localization and degradation with green fluorescent protein Proceedings of the National Academy of Sciences of the United States of America. 93: 828-833. PMID 8570643 DOI: 10.1073/Pnas.93.2.828 |
0.499 |
|
| 1996 |
Hampton R, Dimster-Denk D, Rine J. The biology of HMG-CoA reductase: the pros of contra-regulation Trends in Biochemical Sciences. 21: 140-145. DOI: 10.1016/S0968-0004(96)80168-X |
0.386 |
|
| 1994 |
Hampton RY, Rine J. Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast Journal of Cell Biology. 125: 299-312. PMID 8163547 DOI: 10.1083/Jcb.125.2.299 |
0.554 |
|
| 1992 |
Hampton RY, Raetz CRH. Lipid A 4'-kinase from Escherichia coli: Enzyme assay and preparation of 4'-32P-labeled probes of high specific radioactivity Methods in Enzymology. 209: 466-475. PMID 1323052 DOI: 10.1016/0076-6879(92)09057-A |
0.303 |
|
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