Ernst Niggli, MD - Publications

Affiliations: 
Physiology University of Bern, Bern, Bern, Switzerland 
Area:
Calcium signaling, cardiac muscle
Website:
http://www.physio.unibe.ch/~niggli/

137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lopez R, Janicek R, Fernandez-Tenorio M, Courtehoux M, Matas L, Gerbaud P, Gomez AM, Egger M, Niggli E. Uptake-leak balance of SR Ca determines arrhythmogenic potential of RyR2 cardiomyocytes. Journal of Molecular and Cellular Cardiology. 170: 1-14. PMID 35644481 DOI: 10.1016/j.yjmcc.2022.05.011  0.859
2022 Agarwal HK, Janicek R, Zhao J, Sambath K, Egger M, Niggli E, Ellis-Davies GCR. The yin and yang of intracellular delivery of amphipathic optical probes using -butyl charge masking. Chemical Communications (Cambridge, England). PMID 35112125 DOI: 10.1039/d1cc06792c  0.719
2021 Janicek R, Agarwal H, Gómez AM, Egger M, Ellis-Davies GCR, Niggli E. Local recovery of cardiac calcium-induced calcium release interrogated by ultra-effective, two-photon uncaging of calcium. The Journal of Physiology. PMID 34245001 DOI: 10.1113/JP281482  0.863
2021 Yin L, Zahradnikova A, Rizzetto R, Boncompani S, Rabesahala de Meritens C, Zhang Y, Joanne P, Marques Sule E, Aguilar-Torres Y, Fernandez-Tenorio M, Villejoubert O, Li L, Wang YY, Mateo P, Nicolas V, ... Niggli E, et al. Impaired Binding to Junctophilin2 and Nanostructural Alteration in CPVT Mutation. Circulation Research. PMID 34111951 DOI: 10.1161/CIRCRESAHA.121.319094  0.545
2020 Potenza DM, Janicek R, Fernandez-Tenorio M, Niggli E. Activation of endogenous protein phosphatase 1 enhances the calcium sensitivity of the ryanodine receptor type 2 in murine ventricular cardiomyocytes. The Journal of Physiology. PMID 31943206 DOI: 10.1113/Jp278951  0.847
2020 Lopez Dicuru RJ, Fernandez-Tenorio M, Janicek R, Gomez AM, Niggli E. SERCA Stimulation Triggers Arrhythmogenic Ca2+ Events in Mouse Cardiomyocytes Harboring the RyR2R420Q+/- Mutation Biophysical Journal. 118: 254a. DOI: 10.1016/J.Bpj.2019.11.1482  0.834
2019 Niggli E, Fernandez-Tenorio M. Simultaneous Recording of Subcellular Ca Signals from the Cytosol and Sarco/Endoplasmic Reticulum: Compartmentalized Dye Loading, Imaging, and Analysis. Methods in Molecular Biology (Clifton, N.J.). 1929: 53-71. PMID 30710267 DOI: 10.1007/978-1-4939-9030-6_5  0.704
2019 Janicek R, Michele Potenza D, Fernandez-Tenorio M, Valdivia HH, Niggli E. Activation of Endogenous PP1 Enhances Calcium Spark Activity in Wild Type Cardiomyocytes Biophysical Journal. 116: 384a-385a. DOI: 10.1016/J.Bpj.2018.11.2082  0.74
2018 Illaste A, Wullschleger M, Fernandez-Tenorio M, Niggli E, Egger M. Automatic Detection and Classification of Ca Release Events in Line- and Frame-Scan Images. Biophysical Journal. PMID 30638961 DOI: 10.1016/J.Bpj.2018.12.013  0.611
2018 Potenza DM, Janicek R, Fernandez-Tenorio M, Camors E, Ramos-Mondragón R, Valdivia HH, Niggli E. Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response. The Journal of General Physiology. PMID 30541771 DOI: 10.1085/Jgp.201812155  0.874
2018 Fernandez-Tenorio M, Niggli E. Stabilization of Ca signaling in cardiac muscle by stimulation of SERCA. Journal of Molecular and Cellular Cardiology. PMID 29715473 DOI: 10.1016/J.Yjmcc.2018.04.015  0.667
2018 Michele Potenza D, Janiček R, Fernandez-Tenorio M, Valdivia HH, Niggli E. Dual Ablation of the RYR2-S2808 and RYR2-S2814 Sites Increases Propensity for Pro-arrhythmic Spontaneous Calcium Releases Biophysical Journal. 114: 116a. DOI: 10.1016/J.Bpj.2017.11.669  0.744
2018 Fernandez-Tenorio M, Janicek R, Rizzetto R, Zahradnikova A, Yi Wang Y, Benitah J, Zorio E, Gomez AM, Niggli E. The RyR2R420Q Mutation Triggers Catecholaminergic Polymorphic Ventricular Tachycardia in Mouse Cardiomyocytes via SR Calcium Loading Biophysical Journal. 114: 116a. DOI: 10.1016/J.Bpj.2017.11.668  0.742
2017 Srimachai S, Devaux S, Demougeot C, Kumphune S, Ullrich ND, Niggli E, Ingkaninan K, Kamkaew N, Scholfield CN, Tapechum S, Chootip K. Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury. Bmc Complementary and Alternative Medicine. 17: 117. PMID 28219356 DOI: 10.1186/S12906-017-1637-Z  0.634
2017 Rizzetto R, Fernandez-Tenorio M, Zahradnikova A, Boncompani S, Marqués-Sulé E, Yi Wang Y, Benitah J, Zorio E, Protasi F, Niggli E, Gomez AM. Functional Effects of the RyR 2 R420Q Catecholaminergic Ventricular Polymorphic Tachycardia in Mouse Cardiomyocytes Biophysical Journal. 112: 94a. DOI: 10.1016/J.Bpj.2016.11.551  0.674
2017 Potenza DM, Janicek R, Fernandez-Tenorio M, Valdivia HH, Niggli E. Ablation of the RyR2-Ser2030 Phosphorylation Site Limits Changes in RyR2 Sensitivity during ß-Adrenergic Stimulation Biophysical Journal. 112: 541a-542a. DOI: 10.1016/J.Bpj.2016.11.2925  0.768
2017 Janicek R, Agarwal H, Ellis-Davies GC, Niggli E. Local Recovery of CICR Probed by Ultra-Effective Calcium Uncaging Biophysical Journal. 112: 231a. DOI: 10.1016/J.Bpj.2016.11.1271  0.873
2016 Plaisance I, Perruchoud S, Fernandez-Tenorio M, Gonzales C, Ounzain S, Ruchat P, Nemir M, Niggli E, Pedrazzini T. Cardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression. Jacc. Basic to Translational Science. 1: 472-493. PMID 29707678 DOI: 10.1016/J.Jacbts.2016.06.008  0.308
2016 Fernandez-Tenorio M, Niggli E. Real-time intra-store confocal Ca(2+) imaging in isolated mouse cardiomyocytes. Cell Calcium. PMID 27431464 DOI: 10.1016/J.Ceca.2016.07.002  0.711
2016 Agarwal HK, Janicek R, Chi SH, Perry JW, Niggli E, Ellis-Davies GC. Calcium Uncaging with Visible Light. Journal of the American Chemical Society. PMID 26974387 DOI: 10.1021/Jacs.5B11606  0.856
2016 Janicek R, Agarwal HK, Ellis-Davies GC, Niggli E. One and Two-Photon Calcium Uncaging with Visible Light in Cardiac Myocytes Biophysical Journal. 110: 432a. DOI: 10.1016/J.Bpj.2015.11.2335  0.871
2016 Michele Potenza D, Fernandez-Tenorio M, Niggli E. Protein Phosphatase-1 Increases Calcium Spark Frequency in Murine Cardiomyocytes via Modulation of RyR2 Phosphorylation Biophysical Journal. 110: 269a-270a. DOI: 10.1016/J.Bpj.2015.11.1467  0.658
2015 Shirokova N, Kang C, Fernandez-Tenorio M, Wang W, Wang Q, Wehrens XHT, Niggli E. Erratum: Oxidative Stress and Ca2D Release Events in Mouse Cardiomyocytes (Biophysical Journal (2014) 107 (2815-2827)) Biophysical Journal. 109. PMID 26848493 DOI: 10.1016/J.Bpj.2015.10.007  0.574
2015 Poláková E, Illaste A, Niggli E, Sobie EA. Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes. The Journal of Physiology. 593: 1495-507. PMID 25772298 DOI: 10.1113/Jphysiol.2014.278051  0.457
2015 Niggli E. IP3 and Ca(2+) signals in the heart: boost them or bust them? The Journal of Physiology. 593: 1385-6. PMID 25772293 DOI: 10.1113/Jphysiol.2014.287987  0.705
2015 Lorin C, Vögeli I, Niggli E. Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage. Cardiovascular Research. 106: 153-62. PMID 25616416 DOI: 10.1093/Cvr/Cvv021  0.445
2015 Fernandez-Tenorio M, Niggli E. Opposite Changes of Ca2+ Wave Threshold and Fractional SR Ca2+ Release during SERCA Stimulation in Cardiomyocytes Biophysical Journal. 108: 263a. DOI: 10.1016/J.Bpj.2014.11.1450  0.689
2014 Shirokova N, Kang C, Fernandez-Tenorio M, Wang W, Wang Q, Wehrens XH, Niggli E. Oxidative stress and ca(2+) release events in mouse cardiomyocytes. Biophysical Journal. 107: 2815-27. PMID 25517148 DOI: 10.1016/J.Bpj.2014.10.054  0.789
2014 Poláková E, Illaste A, Niggli E, Sobie EA. Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes. The Journal of Physiology. PMID 25194048 DOI: 10.1113/jphysiol.2014.278051  0.475
2014 Illaste A, Wullschleger M, Fernandez-Tenorio M, Egger M, Niggli E. Extracting Detailed Ca2+ Signaling Information from Noisy Confocal Images Biophysical Journal. 106: 532a. DOI: 10.1016/J.Bpj.2013.11.2970  0.513
2014 Wullschleger M, Illaste A, Niggli E, Egger M. Characterization of Calcium Release Events Evoked by InsP3R Activation in Intact and Permeabilized Atrial Myocytes Biophysical Journal. 106: 532a. DOI: 10.1016/J.Bpj.2013.11.2969  0.688
2014 Illaste A, Polakova E, Niggli E, Sobie EA. Activity of Both PKA and Camkii is Required for Maximal RyR Sensitivity Under Beta-Adrenergic Stimulation Biophysical Journal. 106: 431a. DOI: 10.1016/J.Bpj.2013.11.2426  0.402
2014 Fernandez-Tenorio M, Niggli E. Serca Stimulation Increases Intra-Sr Ca2+Threshold for Ca2+ Waves in Cadiomyocytes Biophysical Journal. 106: 323a. DOI: 10.1016/J.Bpj.2013.11.1862  0.658
2013 Gutierrez DA, Fernandez-Tenorio M, Ogrodnik J, Niggli E. NO-dependent CaMKII activation during β-adrenergic stimulation of cardiac muscle. Cardiovascular Research. 100: 392-401. PMID 23963842 DOI: 10.1093/Cvr/Cvt201  0.879
2013 Kyrychenko S, Poláková E, Kang C, Pocsai K, Ullrich ND, Niggli E, Shirokova N. Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy. Cardiovascular Research. 97: 666-75. PMID 23263329 DOI: 10.1093/Cvr/Cvs425  0.868
2013 Shirokova N, Niggli E. Cardiac phenotype of Duchenne Muscular Dystrophy: insights from cellular studies. Journal of Molecular and Cellular Cardiology. 58: 217-24. PMID 23261966 DOI: 10.1016/J.Yjmcc.2012.12.009  0.606
2013 Niggli E, Ullrich ND, Gutierrez D, Kyrychenko S, Poláková E, Shirokova N. Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling. Biochimica Et Biophysica Acta. 1833: 866-75. PMID 22960642 DOI: 10.1016/J.Bbamcr.2012.08.016  0.879
2013 Fernandez-Tenorio M, Gutierrez D, Niggli E. Improved Protocol to Record Sarcoplasmic Reticulum Calcium Concentrations in Mouse Cardiomyocytes Biophysical Journal. 104: 607a. DOI: 10.1016/J.Bpj.2012.11.3366  0.84
2013 Polakova E, Illaste A, Niggli E, Sobie EA. Factors Influencing Ca2+ Spark Refractoriness in Mouse Biophysical Journal. 104: 438a. DOI: 10.1016/J.Bpj.2012.11.2435  0.697
2013 Gutierrez D, Fernandez-Tenorio M, Ogrodnik J, Niggli E. Direct CaMKII Activation by Endogenous Nitric Oxide Modulates Calcium Spark Frequency in Cardiomyocytes Biophysical Journal. 104: 361a. DOI: 10.1016/J.Bpj.2012.11.2006  0.832
2012 Ullrich ND, Valdivia HH, Niggli E. PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. Journal of Molecular and Cellular Cardiology. 53: 33-42. PMID 22487381 DOI: 10.1016/J.Yjmcc.2012.03.015  0.852
2012 Gonzales C, Ullrich ND, Gerber S, Berthonneche C, Niggli E, Pedrazzini T. Isolation of cardiovascular precursor cells from the human fetal heart. Tissue Engineering. Part A. 18: 198-207. PMID 21902604 DOI: 10.1089/Ten.Tea.2011.0022  0.675
2012 Gutierrez D, Ogrodnik J, Niggli E. Activation of Ca2+ Sparks during β-Adrenergic Stimulation in Resting Cardiomyocytes May Involve CAMKII and No, But Not ROS Biophysical Journal. 102: 98a. DOI: 10.1016/J.Bpj.2011.11.560  0.878
2012 Kyrychenko S, Poláková E, Ullrich ND, Niggli E, Shirokova N. Insights into RyRs Dysfunctions via Studies of Intracellular Calcium Signals Biophysical Journal. 102: 213a. DOI: 10.1016/J.Bpj.2011.11.1167  0.881
2011 Niggli E. Ryanodine receptors: waking up from refractoriness. Cardiovascular Research. 91: 563-4. PMID 21742677 DOI: 10.1093/Cvr/Cvr198  0.709
2011 Niggli E. Measuring calcium in 'fuzzy' spaces. The Journal of Physiology. 589: 2663. PMID 21632527 DOI: 10.1113/Jphysiol.2011.210336  0.703
2011 Ullrich ND, Fischer D, Kornblum C, Walter MC, Niggli E, Zorzato F, Treves S. Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle. Human Mutation. 32: 309-17. PMID 21294223 DOI: 10.1002/Humu.21431  0.8
2011 Kyrychenko S, Poláková E, Poscai K, Ullrich ND, Niggli E, Shirokova N. Hypersensitive Intracellular Ca2+ Signaling Precedes Deterioration of Cardiac Functions in Muscular Dystrophy Biophysical Journal. 100: 562a. DOI: 10.1016/J.Bpj.2010.12.3263  0.885
2011 Gutierrez D, Ogrodnik J, Niggli E. Activation of Calcium Sparks in Resting Cardiomyocytes by β-Adrenergic Stimulation May Involve CaMKII and nNOS Biophysical Journal. 100: 559a. DOI: 10.1016/J.Bpj.2010.12.3248  0.892
2011 Ullrich ND, Niggli E. Cardiac Ryanodine Receptor Phosphorylation at Ser2808 is Involved in Intra-SR Calcium Sensing Biophysical Journal. 100: 353a. DOI: 10.1016/J.Bpj.2010.12.2122  0.85
2010 Swift F, Tovsrud N, Sjaastad I, Sejersted OM, Niggli E, Egger M. Functional coupling of alpha(2)-isoform Na(+)/K(+)-ATPase and Ca(2+) extrusion through the Na(+)/Ca(2+)-exchanger in cardiomyocytes. Cell Calcium. 48: 54-60. PMID 20667414 DOI: 10.1016/J.Ceca.2010.06.006  0.556
2010 Niggli E. Ca2+ on the move: what is better - fire and forget, or fire-diffuse-fire? The Journal of Physiology. 588: 1391-2. PMID 20436043 DOI: 10.1113/Jphysiol.2010.190306  0.673
2010 Ogrodnik J, Niggli E. Increased Ca(2+) leak and spatiotemporal coherence of Ca(2+) release in cardiomyocytes during beta-adrenergic stimulation. The Journal of Physiology. 588: 225-42. PMID 19900959 DOI: 10.1113/Jphysiol.2009.181800  0.878
2010 Ullrich ND, Niggli E. Impaired Ca2+ Release Synchronization in RyR2-S2808a Mouse Cardiomyocytes During β-Adrenergic Stimulation Biophysical Journal. 98: 550a. DOI: 10.1016/J.Bpj.2009.12.2979  0.824
2010 Ogrodnik J, Gutierrez D, Niggli E. β-Adrenergic Stimulation and SR Ca2+ Leak in Cardiomyocytes Biophysical Journal. 98: 549a-550a. DOI: 10.1016/J.Bpj.2009.12.2978  0.896
2010 Fanchaouy M, Pocsai K, Shirokova N, Niggli E. Redox Modifications of Ca2+-Release Events in Cardiomyocytes Biophysical Journal. 98: 549a. DOI: 10.1016/J.Bpj.2009.12.2975  0.8
2009 Gusev K, Ackermann GE, Heizmann CW, Niggli E. Ca2+ signaling in mouse cardiomyocytes with ablated S100A1 protein. General Physiology and Biophysics. 28: 371-83. PMID 20097960 DOI: 10.4149/Gpb_2009_04_371  0.846
2009 Sztretye M, Almássy J, Deli T, Szentesi P, Jung C, Dienes B, Simut CA, Niggli E, Jona I, Csernoch L. Altered sarcoplasmic reticulum calcium transport in the presence of the heavy metal chelator TPEN. Cell Calcium. 46: 347-55. PMID 19900703 DOI: 10.1016/J.Ceca.2009.10.002  0.853
2009 Niggli E. How to shut down Ca2+-induced Ca2+ release? The Journal of Physiology. 587: 5003-4. PMID 19880872 DOI: 10.1113/Jphysiol.2009.181578  0.717
2009 Ullrich ND, Fanchaouy M, Gusev K, Shirokova N, Niggli E. Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. 297: H1992-2003. PMID 19783774 DOI: 10.1152/Ajpheart.00602.2009  0.876
2009 Fanchaouy M, Polakova E, Jung C, Ogrodnik J, Shirokova N, Niggli E. Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes. Cell Calcium. 46: 114-21. PMID 19604578 DOI: 10.1016/J.Ceca.2009.06.002  0.875
2009 Gusev K, Domenighetti AA, Delbridge LM, Pedrazzini T, Niggli E, Egger M. Angiotensin II-mediated adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling. Circulation Research. 105: 42-50. PMID 19478206 DOI: 10.1161/Circresaha.108.189779  0.799
2009 Shkryl VM, Martins AS, Ullrich ND, Nowycky MC, Niggli E, Shirokova N. Reciprocal amplification of ROS and Ca(2+) signals in stressed mdx dystrophic skeletal muscle fibers. Pflã¼Gers Archiv : European Journal of Physiology. 458: 915-28. PMID 19387681 DOI: 10.1007/S00424-009-0670-2  0.832
2009 Gusev K, Domenighetti AA, Delbridge LMD, Pedrazzini T, Niggli E, Egger M. Erratum: Angiotensin II-mediated adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling (Circulation Research (2009) 105 (42-50)) Circulation Research. 105. DOI: 10.1161/Res.0B013E3181Bc39Fc  0.61
2009 Ullrich ND, Fanchaouy M, Gusev K, Polakova E, Shirokova N, Niggli E. Changes of EC-coupling and RyR Calcium Sensitivity in Dystrophic mdx Mouse Cardiomyocytes Biophysical Journal. 96: 10a-11a. DOI: 10.1016/J.Bpj.2008.12.951  0.892
2009 Ogrodnik J, Niggli E. Altered Ryanodine Receptor Sensitivity after ß-Adrenergic Stimulation of Guinea-pig Ventricular Myocytes Biophysical Journal. 96: 276a. DOI: 10.1016/J.Bpj.2008.12.1365  0.879
2008 Gusev K, Niggli E. Modulation of the local SR Ca2+ release by intracellular Mg2+ in cardiac myocytes. The Journal of General Physiology. 132: 721-30. PMID 19029377 DOI: 10.1085/Jgp.200810119  0.823
2008 Shirokova N, Niggli E. Studies of RyR function in situ. Methods (San Diego, Calif.). 46: 183-93. PMID 18848990 DOI: 10.1016/J.Ymeth.2008.09.017  0.769
2008 Jung C, Martins AS, Niggli E, Shirokova N. Dystrophic cardiomyopathy: amplification of cellular damage by Ca2+ signalling and reactive oxygen species-generating pathways. Cardiovascular Research. 77: 766-73. PMID 18056762 DOI: 10.1093/Cvr/Cvm089  0.804
2007 Keller M, Pignier C, Egger M, Niggli E. F90927: a new member in the class of cardioactive steroids. Cardiovascular Drug Reviews. 25: 210-20. PMID 17919256 DOI: 10.1111/J.1527-3466.2007.00014.X  0.819
2007 Niggli E, Shirokova N. A guide to sparkology: the taxonomy of elementary cellular Ca2+ signaling events. Cell Calcium. 42: 379-87. PMID 17428535 DOI: 10.1016/J.Ceca.2007.02.010  0.767
2007 Keller M, Kao JP, Egger M, Niggli E. Calcium waves driven by "sensitization" wave-fronts. Cardiovascular Research. 74: 39-45. PMID 17336953 DOI: 10.1016/J.Cardiores.2007.02.006  0.685
2007 Niggli E. The cardiac sarcoplasmic reticulum: filled with Ca2+ and surprises. Circulation Research. 100: 5-6. PMID 17204657 DOI: 10.1161/01.Res.0000255896.06757.97  0.709
2007 Jung C, Zima AV, Szentesi P, Jona I, Blatter LA, Niggli E. Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes. Cell Calcium. 41: 187-94. PMID 16920191 DOI: 10.1016/J.Ceca.2006.06.009  0.865
2006 Keller M, Pignier C, Santelli M, Vacher B, Niggli E, Egger M. Agonist specific L-type Ca(2+)-current stimulation in ventricular myocytes by a novel steroid-like compound. Cell Calcium. 39: 425-33. PMID 16540165 DOI: 10.1016/J.Ceca.2006.01.006  0.856
2006 Kléber AG, Niggli E, McGuigan JA, Weingart R. The early years of cellular cardiac electrophysiology and Silvio Weidmann (1921-2005). Heart Rhythm : the Official Journal of the Heart Rhythm Society. 3: 353-9. PMID 16500311 DOI: 10.1016/J.Hrthm.2005.11.017  0.71
2006 Pignier C, Keller M, Vié B, Vacher B, Santelli M, Niggli E, Egger M, Le Grand B. A novel steroid-like compound F90927 exerting positive-inotropic effects in cardiac muscle. British Journal of Pharmacology. 147: 772-82. PMID 16474419 DOI: 10.1038/Sj.Bjp.0706673  0.748
2006 Momotake A, Lindegger N, Niggli E, Barsotti RJ, Ellis-Davies GC. The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nature Methods. 3: 35-40. PMID 16369551 DOI: 10.1038/Nmeth821  0.745
2006 Niggli E, Kléber A, Weingart R. Founder of cardiac cellular electrophysiology: honouring Silvio Weidmann, 7 April 1921- 11 July 2005. The Journal of Physiology. 570: 431-2. PMID 16322050 DOI: 10.1113/Jphysiol.2005.101550  0.737
2006 Kantevari S, Hoang CJ, Ogrodnik J, Egger M, Niggli E, Ellis-Davies GC. Synthesis and two-photon photolysis of 6-(ortho-nitroveratryl)-caged IP3 in living cells. Chembiochem : a European Journal of Chemical Biology. 7: 174-80. PMID 16292788 DOI: 10.1002/Cbic.200500345  0.757
2005 Shannon TR, Bers DM, Blatter LA, Niggli E. Confocal imaging of CICR events from isolated and immobilized SR vesicles. Cell Calcium. 38: 497-505. PMID 16122794 DOI: 10.1016/J.Ceca.2005.07.002  0.685
2005 Lindegger N, Niggli E. Paradoxical SR Ca2+ release in guinea-pig cardiac myocytes after beta-adrenergic stimulation revealed by two-photon photolysis of caged Ca2+. The Journal of Physiology. 565: 801-13. PMID 15774509 DOI: 10.1113/Jphysiol.2005.084376  0.811
2005 Egger M, Porzig H, Niggli E, Schwaller B. Rapid turnover of the "functional" Na(+)-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach. Cell Calcium. 37: 233-43. PMID 15670870 DOI: 10.1016/J.Ceca.2004.10.006  0.508
2004 Szentesi P, Pignier C, Egger M, Kranias EG, Niggli E. Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle. Circulation Research. 95: 807-13. PMID 15388639 DOI: 10.1161/01.Res.0000146029.80463.7D  0.897
2004 Keller M, Pignier C, Niggli E, Egger M. Mechanisms of Na+-Ca2+ exchange inhibition by amphiphiles in cardiac myocytes: importance of transbilayer movement. The Journal of Membrane Biology. 198: 159-75. PMID 15216417 DOI: 10.1007/S00232-004-0668-9  0.843
2003 Zhang H, Noble D, Cannell M, Orchard CH, Lancaster M, Jones SA, Boyett MR, Holden AV, Jafri MS, Sobie EA, Lederer WJ, Demir SS, Michailova A, Delprincipe F, Egger M, ... Niggli E, et al. Dynamics of cardiac intracellular Ca2+ handling - From experiments to virtual cells International Journal of Bifurcation and Chaos in Applied Sciences and Engineering. 13: 3535-3560. DOI: 10.1142/S0218127403008843  0.853
2002 Michailova A, DelPrincipe F, Egger M, Niggli E. Spatiotemporal features of Ca2+ buffering and diffusion in atrial cardiac myocytes with inhibited sarcoplasmic reticulum. Biophysical Journal. 83: 3134-51. PMID 12496084 DOI: 10.1016/S0006-3495(02)75317-4  0.886
2002 Darbon P, Pignier C, Niggli E, Streit J. Involvement of calcium in rhythmic activity induced by disinhibition in cultured spinal cord networks. Journal of Neurophysiology. 88: 1461-8. PMID 12205166 DOI: 10.1152/Jn.2002.88.3.1461  0.8
2002 Gómez AM, Schwaller B, Porzig H, Vassort G, Niggli E, Egger M. Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarction. Circulation Research. 91: 323-30. PMID 12193465 DOI: 10.1161/01.Res.0000031384.55006.Db  0.685
2002 Lipp P, Egger M, Niggli E. Spatial characteristics of sarcoplasmic reticulum Ca2+ release events triggered by L-type Ca2+ current and Na+ current in guinea-pig cardiac myocytes. The Journal of Physiology. 542: 383-93. PMID 12122139 DOI: 10.1113/Jphysiol.2001.013382  0.804
2002 Niggli E, Egger M. Calcium quarks. Frontiers in Bioscience : a Journal and Virtual Library. 7: d1288-97. PMID 11991844  0.571
2000 DelPrincipe F, Egger M, Niggli E. L-type Ca2+ current as the predominant pathway of Ca2+ entry during I(Na) activation in beta-stimulated cardiac myocytes. The Journal of Physiology. 527: 455-66. PMID 10990533 DOI: 10.1111/J.1469-7793.2000.00455.X  0.885
2000 Egger M, Niggli E. Paradoxical block of the Na+-Ca2+ exchanger by extracellular protons in guinea-pig ventricular myocytes. The Journal of Physiology. 523: 353-66. PMID 10699080 DOI: 10.1111/J.1469-7793.2000.T01-1-00353.X  0.682
2000 Schwaller B, Egger M, Lipp P, Niggli E. Application of antisense oligodeoxynucleotides for suppression of Na+/Ca2+ exchange. Methods in Enzymology. 314: 454-76. PMID 10565032 DOI: 10.1016/S0076-6879(99)14122-3  0.77
1999 Niggli E. Ca(2+) Sparks in Cardiac Muscle: Is There Life Without Them? News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 14: 129-134. PMID 11390838 DOI: 10.1152/Physiologyonline.1999.14.4.129  0.64
1999 DelPrincipe F, Egger M, Niggli E. Calcium signalling in cardiac muscle: refractoriness revealed by coherent activation. Nature Cell Biology. 1: 323-9. PMID 10559957 DOI: 10.1038/14013  0.892
1999 Egger M, Ruknudin A, Niggli E, Lederer WJ, Schulze DH. Ni2+ transport by the human Na+/Ca2+ exchanger expressed in Sf9 cells. The American Journal of Physiology. 276: C1184-92. PMID 10329968 DOI: 10.1152/Ajpcell.1999.276.5.C1184  0.696
1999 DelPrincipe F, Egger M, Ellis-Davies GC, Niggli E. Two-photon and UV-laser flash photolysis of the Ca2+ cage, dimethoxynitrophenyl-EGTA-4. Cell Calcium. 25: 85-91. PMID 10191963 DOI: 10.1054/Ceca.1998.0009  0.869
1999 Egger M, Ruknudin A, Lipp P, Kofuji P, Lederer WJ, Schulze DH, Niggli E. Functional expression of the human cardiac Na+/Ca2+ exchanger in Sf9 cells: rapid and specific Ni2+ transport. Cell Calcium. 25: 9-17. PMID 10191956 DOI: 10.1054/Ceca.1998.0002  0.816
1999 Niggli E. Localized intracellular calcium signaling in muscle: calcium sparks and calcium quarks. Annual Review of Physiology. 61: 311-35. PMID 10099691 DOI: 10.1146/Annurev.Physiol.61.1.311  0.703
1999 Egger M, Niggli E. Regulatory function of Na-Ca exchange in the heart: milestones and outlook. The Journal of Membrane Biology. 168: 107-30. PMID 10089232 DOI: 10.1007/S002329900502  0.594
1999 Assandri R, Egger M, Gassmann M, Niggli E, Bauer C, Forster I, Gorlach A. Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line. The Journal of Physiology. 516: 343-52. PMID 10087335 DOI: 10.1111/J.1469-7793.1999.0343V.X  0.622
1999 Niggli E. Ca2+ sparks in cardiac muscle: Is there life without them? News in Physiological Sciences. 14: 129-134.  0.479
1998 Blatter LA, Niggli E. Confocal near-membrane detection of calcium in cardiac myocytes. Cell Calcium. 23: 269-79. PMID 9681190 DOI: 10.1016/S0143-4160(98)90023-9  0.664
1998 Lipp P, Niggli E. Fundamental calcium release events revealed by two-photon excitation photolysis of caged calcium in Guinea-pig cardiac myocytes. The Journal of Physiology. 508: 801-9. PMID 9518734 DOI: 10.1111/J.1469-7793.1998.801Bp.X  0.811
1997 Bootman M, Niggli E, Berridge M, Lipp P. Imaging the hierarchical Ca2+ signalling system in HeLa cells. The Journal of Physiology. 499: 307-14. PMID 9080361 DOI: 10.1113/Jphysiol.1997.Sp021928  0.798
1997 Bootman M, Niggli E, Berridge M, Lipp P. Imaging the hierarchical Ca2+ signalling system in HeLa cells Journal of Physiology. 499: 307-314.  0.481
1996 Lipp P, Niggli E. A hierarchical concept of cellular and subcellular Ca(2+)-signalling. Progress in Biophysics and Molecular Biology. 65: 265-96. PMID 9062435 DOI: 10.1016/S0079-6107(96)00014-4  0.753
1996 Hüser J, Lipp P, Niggli E. Confocal microscopic detection of potential-sensitive dyes used to reveal loss of voltage control during patch-clamp experiments. Pflã¼Gers Archiv : European Journal of Physiology. 433: 194-9. PMID 9019723 DOI: 10.1007/S004240050267  0.542
1996 Lipp P, Hüser J, Pott L, Niggli E. Subcellular properties of triggered Ca2+ waves in isolated citrate-loaded guinea-pig atrial myocytes characterized by ratiometric confocal microscopy. The Journal of Physiology. 497: 599-610. PMID 9003547 DOI: 10.1113/Jphysiol.1996.Sp021793  0.803
1996 Lipp P, Hüser J, Pott L, Niggli E. Spatially non-uniform Ca2+ signals induced by the reduction of transverse tubules in citrate-loaded guinea-pig ventricular myocytes in culture. The Journal of Physiology. 497: 589-97. PMID 9003546 DOI: 10.1113/Jphysiol.1996.Sp021792  0.797
1996 Lüscher C, Lipp P, Lüscher HR, Niggli E. Control of action potential propagation by intracellular Ca2+ in cultured rat dorsal root ganglion cells. The Journal of Physiology. 490: 319-24. PMID 8821131 DOI: 10.1113/Jphysiol.1996.Sp021146  0.77
1996 Lipp P, Lüscher C, Niggli E. Photolysis of caged compounds characterized by ratiometric confocal microscopy: a new approach to homogeneously control and measure the calcium concentration in cardiac myocytes. Cell Calcium. 19: 255-66. PMID 8732265 DOI: 10.1016/S0143-4160(96)90026-3  0.802
1996 Lipp P, Niggli E. Submicroscopic calcium signals as fundamental events of excitation--contraction coupling in guinea-pig cardiac myocytes. The Journal of Physiology. 492: 31-8. PMID 8730580 DOI: 10.1113/Jphysiol.1996.Sp021286  0.81
1996 Niggli E, Schwaller B, Lipp P. Antisense oligodeoxynucleotides directed against the Na-Ca exchanger mRNA. Promising tools for studies on the cellular and molecular level. Annals of the New York Academy of Sciences. 779: 93-102. PMID 8659885 DOI: 10.1111/J.1749-6632.1996.Tb44773.X  0.692
1995 Trafford AW, Lipp P, O'Neill SC, Niggli E, Eisner DA. Propagating calcium waves initiated by local caffeine application in rat ventricular myocytes. The Journal of Physiology. 489: 319-26. PMID 8847628 DOI: 10.1113/Jphysiol.1995.Sp021053  0.769
1995 Niggli E, Lipp P. Subcellular features of calcium signalling in heart muscle: what do we learn? Cardiovascular Research. 29: 441-8. PMID 7796437 DOI: 10.1016/S0008-6363(96)88517-8  0.543
1995 Lipp P, Schwaller B, Niggli E. Specific inhibition of Na-Ca exchange function by antisense oligodeoxynucleotides. Febs Letters. 364: 198-202. PMID 7750570 DOI: 10.1016/0014-5793(95)00391-L  0.791
1994 Niggli E, Piston DW, Kirby MS, Cheng H, Sandison DR, Webb WW, Lederer WJ. A confocal laser scanning microscope designed for indicators with ultraviolet excitation wavelengths. The American Journal of Physiology. 266: C303-10. PMID 8304426 DOI: 10.1152/Ajpcell.1994.266.1.C303  0.554
1994 Lipp P, Niggli E. Modulation of Ca2+ release in cultured neonatal rat cardiac myocytes. Insight from subcellular release patterns revealed by confocal microscopy. Circulation Research. 74: 979-90. PMID 8156645 DOI: 10.1161/01.Res.74.5.979  0.783
1994 Lipp P, Niggli E. Sodium current-induced calcium signals in isolated guinea-pig ventricular myocytes. The Journal of Physiology. 474: 439-46. PMID 8014905 DOI: 10.1113/Jphysiol.1994.Sp020035  0.81
1994 Niggli E, Lipp P. Voltage dependence of Na-Ca exchanger conformational currents. Biophysical Journal. 67: 1516-24. PMID 7819485 DOI: 10.1016/S0006-3495(94)80625-3  0.764
1993 Lipp P, Niggli E. Ratiometric confocal Ca(2+)-measurements with visible wavelength indicators in isolated cardiac myocytes. Cell Calcium. 14: 359-72. PMID 8519060 DOI: 10.1016/0143-4160(93)90040-D  0.752
1993 Niggli E, Lipp P. Subcellular restricted spaces: significance for cell signalling and excitation-contraction coupling. Journal of Muscle Research and Cell Motility. 14: 288-91. PMID 8395542 DOI: 10.1007/Bf00123093  0.531
1993 Lipp P, Niggli E. Microscopic spiral waves reveal positive feedback in subcellular calcium signaling. Biophysical Journal. 65: 2272-6. PMID 8312468 DOI: 10.1016/S0006-3495(93)81316-X  0.778
1993 Schulze D, Kofuji P, Hadley R, Kirby MS, Kieval RS, Doering A, Niggli E, Lederer WJ. Sodium/calcium exchanger in heart muscle: molecular biology, cellular function, and its special role in excitation-contraction coupling. Cardiovascular Research. 27: 1726-34. PMID 8275517 DOI: 10.1093/Cvr/27.10.1726  0.707
1993 Niggli E, Lederer WJ. Activation of Na-Ca exchange current by photolysis of "caged calcium". Biophysical Journal. 65: 882-91. PMID 8218911 DOI: 10.1016/S0006-3495(93)81105-6  0.749
1991 Lederer WJ, Niggli E, Hadley RW. Response. Science (New York, N.Y.). 251: 1371. PMID 17816192 DOI: 10.1126/science.251.4999.1371  0.31
1991 Niggli E, Lederer WJ. Molecular operations of the sodium-calcium exchanger revealed by conformation currents. Nature. 349: 621-4. PMID 2000135 DOI: 10.1038/349621A0  0.675
1991 Niggli E, Lederer WJ. Restoring forces in cardiac myocytes. Insight from relaxations induced by photolysis of caged ATP. Biophysical Journal. 59: 1123-35. PMID 1868157 DOI: 10.1016/S0006-3495(91)82327-X  0.537
1991 Niggli E, Lederer WJ. Photorelease of Ca2+ produces Na-Ca exchange currents and Na-Ca exchange "gating" currents. Annals of the New York Academy of Sciences. 639: 61-70. PMID 1785890 DOI: 10.1111/J.1749-6632.1991.Tb17289.X  0.738
1990 Niggli E, Lederer WJ. Real-time confocal microscopy and calcium measurements in heart muscle cells: towards the development of a fluorescence microscope with high temporal and spatial resolution. Cell Calcium. 11: 121-30. PMID 2354496 DOI: 10.1016/0143-4160(90)90065-3  0.506
1990 Lederer WJ, Niggli E, Hadley RW. Sodium-calcium exchange in excitable cells: fuzzy space. Science (New York, N.Y.). 248: 283. PMID 2326638 DOI: 10.1126/Science.2326638  0.564
1990 Nichols CG, Niggli E, Lederer WJ. Modulation of ATP-sensitive potassium channel activity by flash-photolysis of 'caged-ATP' in rat heart cells. Pflã¼Gers Archiv : European Journal of Physiology. 415: 510-2. PMID 2315010 DOI: 10.1007/Bf00373635  0.47
1990 Niggli E, Lederer WJ. Voltage-independent calcium release in heart muscle. Science (New York, N.Y.). 250: 565-8. PMID 2173135 DOI: 10.1126/Science.2173135  0.71
1989 Niggli E. Strontium-induced creep currents associated with tonic contractions in cardiac myocytes isolated from guinea-pigs. The Journal of Physiology. 414: 549-68. PMID 2607441 DOI: 10.1113/Jphysiol.1989.Sp017703  0.573
1989 Niggli E, Rüdisüli A, Maurer P, Weingart R. Effects of general anesthetics on current flow across membranes in guinea pig myocytes. The American Journal of Physiology. 256: C273-81. PMID 2537569 DOI: 10.1152/Ajpcell.1989.256.2.C273  0.737
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