Mariano Barbacid - Publications

Affiliations: 
Molecular Oncology Programme CNIO, Madrid, Comunidad de Madrid, Spain 
Area:
molecular oncology, mouse models, signaling

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Esteban-Burgos L, Wang H, Nieto P, Zheng J, Blanco-Aparicio C, Varela C, Gómez-López G, Fernández-García F, Sanclemente M, Guerra C, Drosten M, Galán J, Caleiras E, Martínez-Torrecuadrada J, Fajas L, ... ... Barbacid M, et al. Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas. Proceedings of the National Academy of Sciences of the United States of America. PMID 32913049 DOI: 10.1073/Pnas.2002520117  0.323
2020 Drosten M, Barbacid M. Targeting the MAPK Pathway in KRAS-Driven Tumors. Cancer Cell. 37: 543-550. PMID 32289276 DOI: 10.1016/J.Ccell.2020.03.013  0.335
2020 Vitos-Faleato J, Real SM, Gutierrez-Prat N, Villanueva A, Llonch E, Drosten M, Barbacid M, Nebreda AR. Requirement for epithelial p38α in KRAS-driven lung tumor progression. Proceedings of the National Academy of Sciences of the United States of America. PMID 31969449 DOI: 10.1073/Pnas.1921404117  0.324
2020 Barbacid M. Abstract IA11: The use of GEM tumor models to identify effective therapies against KRAS mutant tumors Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-Ia11  0.34
2019 García-Gutiérrez L, Bretones G, Molina E, Arechaga I, Symonds C, Acosta JC, Blanco R, Fernández A, Alonso L, Sicinski P, Barbacid M, Santamaría D, León J. Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27. Scientific Reports. 9: 18693. PMID 31822694 DOI: 10.1038/S41598-019-54917-1  0.323
2019 Blasco MT, Navas C, Martín-Serrano G, Graña-Castro O, Lechuga CG, Martín-Díaz L, Djurec M, Li J, Morales-Cacho L, Esteban-Burgos L, Perales-Patón J, Bousquet-Mur E, Castellano E, Jacob HKC, Cabras L, ... ... Barbacid M, et al. Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF. Cancer Cell. PMID 30975481 DOI: 10.1016/J.Ccell.2019.03.002  0.309
2018 Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, Fernandez-Capetillo O. ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Genes & Development. PMID 29650524 DOI: 10.1101/Gad.310086.117  0.337
2018 Simón-Carrasco L, Jiménez G, Barbacid M, Drosten M. The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer. Cell Cycle (Georgetown, Tex.). 1-33. PMID 29578365 DOI: 10.1080/15384101.2018.1450029  0.362
2018 Gao Y, Chang MT, McKay D, Na N, Zhou B, Yaeger RD, Torres NM, Muniz K, Drosten M, Barbacid M, Caponigro G, Stuart D, Moebitz H, Solit DB, Abdel-Wahab OI, et al. Allele-specific mechanisms of activation of MEK1 mutants determine their properties. Cancer Discovery. PMID 29483135 DOI: 10.1158/2159-8290.Cd-17-1452  0.36
2017 Chirivella L, Kirstein M, Ferrón SR, Domingo-Muelas A, Durupt FC, Acosta-Umanzor C, Cano-Jaimez M, Pérez-Sánchez F, Barbacid M, Ortega S, Burks D, Fariñas I. Cdk4 regulates adult neural stem cell proliferation and differentiation in response to insulin-IRS2 signals. Stem Cells (Dayton, Ohio). PMID 28833887 DOI: 10.1002/Stem.2694  0.318
2017 Drosten M, Guerra C, Barbacid M. Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets. Cold Spring Harbor Perspectives in Medicine. PMID 28778964 DOI: 10.1101/Cshperspect.A031542  0.324
2017 Forés M, Simón-Carrasco L, Ajuria L, Samper N, González-Crespo S, Drosten M, Barbacid M, Jiménez G. A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer. Plos Genetics. 13: e1006622. PMID 28278156 DOI: 10.1371/Journal.Pgen.1006622  0.312
2017 Yao Z, Yaeger R, Rodrik-Outmezguine VS, Tao A, Torres NM, Chang MT, Drosten M, Zhao H, Cecchi F, Hembrough T, Michels J, Baumert H, Miles L, Campbell NM, Stanchina Ed, ... ... Barbacid M, et al. Abstract 4078: Tumors with class 3 BRAF mutants are sensitive to the inhibition of activated RAS Cancer Research. 77: 4078-4078. DOI: 10.1158/1538-7445.Am2017-4078  0.36
2016 Drosten M, Simón-Carrasco L, Hernández-Porras I, Lechuga CG, Blasco MT, Jacob HK, Fabbiano S, Potenza N, Bustelo XR, Guerra C, Barbacid M. H-Ras and K-Ras oncoproteins induce different tumor spectra when driven by the same regulatory sequences. Cancer Research. PMID 27872088 DOI: 10.1158/0008-5472.Can-16-2925  0.338
2016 Ambrogio C, Barbacid M, Santamaría D. In vivo oncogenic conflict triggered by co-existing KRAS and EGFR activating mutations in lung adenocarcinoma. Oncogene. 36: 2309-2318. PMID 27775074 DOI: 10.1038/Onc.2016.385  0.323
2016 Papale A, d'Isa R, Menna E, Cerovic M, Solari N, Hardingham N, Cambiaghi M, Cursi M, Barbacid M, Leocani L, Fasano S, Matteoli M, Brambilla R. Severe Intellectual Disability and Enhanced Gamma-Aminobutyric Acidergic Synaptogenesis in a Novel Model of Rare RASopathies. Biological Psychiatry. PMID 27587266 DOI: 10.1016/J.Biopsych.2016.06.016  0.54
2016 Drosten M, Barbacid M. Ras and p53: An unsuspected liaison. Molecular & Cellular Oncology. 3: e996001. PMID 27308624 DOI: 10.1080/23723556.2014.996001  0.326
2016 Ambrogio C, Gómez-López G, Falcone M, Vidal A, Nadal E, Crosetto N, Blasco RB, Fernández-Marcos PJ, Sánchez-Céspedes M, Ren X, Wang Z, Ding K, Hidalgo M, Serrano M, Villanueva A, ... ... Barbacid M, et al. Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma. Nature Medicine. PMID 26855149 DOI: 10.1038/Nm.4041  0.322
2016 Garcia-Gutierrez L, Bretones G, Arechaga I, Santamaria D, Barbacid M, Leon J. Myc-dependent cell cycle progression through the activation of CDK1 and phosphorylation of p27 European Journal of Cancer. 61: S78. DOI: 10.1016/S0959-8049(16)61270-4  0.32
2015 Drosten M, Barbacid M. Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets. Journal of Molecular Medicine (Berlin, Germany). PMID 26526121 DOI: 10.1007/S00109-015-1360-5  0.317
2015 García-Beccaria M, Martínez P, Méndez-Pertuz M, Martínez S, Blanco-Aparicio C, Cañamero M, Mulero F, Ambrogio C, Flores JM, Megias D, Barbacid M, Pastor J, Blasco MA. Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage. Embo Molecular Medicine. PMID 25971796 DOI: 10.15252/Emmm.201404497  0.326
2015 Trakala M, Rodríguez-Acebes S, Maroto M, Symonds CE, Santamaría D, Ortega S, Barbacid M, Méndez J, Malumbres M. Functional reprogramming of polyploidization in megakaryocytes. Developmental Cell. 32: 155-67. PMID 25625205 DOI: 10.1016/J.Devcel.2014.12.015  0.328
2015 Barbacid M. Abstract IA25: Targeting K-Ras signaling in pancreatic cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-Ia25  0.371
2015 Djurec M, Grana O, Pisano D, Lee A, Rabadan R, Guerra C, Barbacid M. Abstract A44: Targeting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma: Identification and characterization of therapeutic candidates Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A44  0.364
2015 Barbacid M. Abstract PL03-01: Targeting K-RAS driven cancer Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-Pl03-01  0.375
2014 Hernández-Porras I, Fabbiano S, Schuhmacher AJ, Aicher A, Cañamero M, Cámara JA, Cussó L, Desco M, Heeschen C, Mulero F, Bustelo XR, Guerra C, Barbacid M. K-RasV14I recapitulates Noonan syndrome in mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 16395-400. PMID 25359213 DOI: 10.1073/Pnas.1418126111  0.32
2014 Drosten M, Sum EY, Lechuga CG, Simón-Carrasco L, Jacob HK, García-Medina R, Huang S, Beijersbergen RL, Bernards R, Barbacid M. Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 111: 15155-60. PMID 25288756 DOI: 10.1073/Pnas.1417549111  0.366
2014 Drosten M, Lechuga CG, Barbacid M. Ras in epidermal proliferation. Oncotarget. 5: 5194-5. PMID 25114036 DOI: 10.18632/Oncotarget.2275  0.349
2014 Cerqueira A, Martín A, Symonds CE, Odajima J, Dubus P, Barbacid M, Santamaría D. Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors. Molecular and Cellular Biology. 34: 1452-9. PMID 24515438 DOI: 10.1128/Mcb.01163-13  0.329
2014 Mainardi S, Mijimolle N, Francoz S, Vicente-Dueñas C, Sánchez-García I, Barbacid M. Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. 111: 255-60. PMID 24367082 DOI: 10.1073/Pnas.1320383110  0.334
2014 Drosten M, Lechuga CG, Barbacid M. Ras signaling is essential for skin development. Oncogene. 33: 2857-65. PMID 23831572 DOI: 10.1038/Onc.2013.254  0.342
2014 Hu W, Nevzorova YA, Haas U, Moro N, Sicinski P, Geng Y, Barbacid M, Trautwein C, Liedtke C. Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. Hepatology (Baltimore, Md.). 59: 651-60. PMID 23787781 DOI: 10.1002/Hep.26584  0.313
2013 Azrak SS, Ginel-Picardo A, Drosten M, Barbacid M, Santos E. Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications. Bmc Genomics. 14: 731. PMID 24156637 DOI: 10.1186/1471-2164-14-731  0.335
2013 Drosten M, Lechuga CG, Barbacid M. Genetic analysis of Ras genes in epidermal development and tumorigenesis. Small Gtpases. 4: 236-41. PMID 24150175 DOI: 10.4161/Sgtp.26905  0.332
2013 González-Sánchez E, Martín-Caballero J, Flores JM, Hernández-Losa J, Cortés J, Mares R, Barbacid M, Recio JA. Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas. Plos One. 8: e66933. PMID 23825589 DOI: 10.1371/Journal.Pone.0066933  0.322
2013 Guerra C, Barbacid M. Genetically engineered mouse models of pancreatic adenocarcinoma. Molecular Oncology. 7: 232-47. PMID 23506980 DOI: 10.1016/J.Molonc.2013.02.002  0.31
2012 Navas C, Hernández-Porras I, Schuhmacher AJ, Sibilia M, Guerra C, Barbacid M. EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell. 22: 318-30. PMID 22975375 DOI: 10.1016/J.Ccr.2012.08.001  0.343
2012 Martínez González S, Hernández AI, Varela C, Lorenzo M, Ramos-Lima F, Cendón E, Cebrián D, Aguirre E, Gomez-Casero E, Albarrán MI, Alfonso P, García-Serelde B, Mateos G, Oyarzabal J, Rabal O, ... ... Barbacid M, et al. Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR. Bioorganic & Medicinal Chemistry Letters. 22: 5208-14. PMID 22819764 DOI: 10.1016/J.Bmcl.2012.06.093  0.36
2012 Barbacid M. Opening a new GATAway for treating KRAS-driven lung tumors. Cancer Cell. 21: 598-600. PMID 22624710 DOI: 10.1016/J.Ccr.2012.04.032  0.307
2012 Martínez González S, Hernández AI, Varela C, Rodríguez-Arístegui S, Lorenzo M, Rodríguez A, Rivero V, Martín JI, Saluste CG, Ramos-Lima F, Cendón E, Cebrián D, Aguirre E, Gomez-Casero E, Albarrán M, ... ... Barbacid M, et al. Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 3460-6. PMID 22520259 DOI: 10.1016/J.Bmcl.2012.03.090  0.331
2012 Ganuza M, Sáiz-Ladera C, Cañamero M, Gómez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamaría D, Barbacid M. Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. The Embo Journal. 31: 2498-510. PMID 22505032 DOI: 10.1038/Emboj.2012.94  0.325
2011 Matallanas D, Romano D, Al-Mulla F, O'Neill E, Al-Ali W, Crespo P, Doyle B, Nixon C, Sansom O, Drosten M, Barbacid M, Kolch W. Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Molecular Cell. 44: 893-906. PMID 22195963 DOI: 10.1016/J.Molcel.2011.10.016  0.327
2011 Guerra C, Collado M, Navas C, Schuhmacher AJ, Hernández-Porras I, Cañamero M, Rodriguez-Justo M, Serrano M, Barbacid M. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell. 19: 728-39. PMID 21665147 DOI: 10.1016/J.Ccr.2011.05.011  0.301
2011 Blasco RB, Francoz S, Santamaría D, Cañamero M, Dubus P, Charron J, Baccarini M, Barbacid M. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell. 19: 652-63. PMID 21514245 DOI: 10.1016/J.Ccr.2011.04.002  0.363
2011 Urosevic J, Sauzeau V, Soto-Montenegro ML, Reig S, Desco M, Wright EM, Cañamero M, Mulero F, Ortega S, Bustelo XR, Barbacid M. Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Proceedings of the National Academy of Sciences of the United States of America. 108: 5015-20. PMID 21383153 DOI: 10.1073/Pnas.1016933108  0.32
2010 Puyol M, Martín A, Dubus P, Mulero F, Pizcueta P, Khan G, Guerra C, Santamaría D, Barbacid M. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell. 18: 63-73. PMID 20609353 DOI: 10.1016/J.Ccr.2010.05.025  0.342
2010 Lauth M, Bergström A, Shimokawa T, Tostar U, Jin Q, Fendrich V, Guerra C, Barbacid M, ToftgÃ¥rd R. DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nature Structural & Molecular Biology. 17: 718-25. PMID 20512148 DOI: 10.1038/Nsmb.1833  0.337
2010 Drosten M, Dhawahir A, Sum EY, Urosevic J, Lechuga CG, Esteban LM, Castellano E, Guerra C, Santos E, Barbacid M. Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. The Embo Journal. 29: 1091-104. PMID 20150892 DOI: 10.1038/Emboj.2010.7  0.354
2009 Urosevic J, Sum EY, Moneo V, Drosten M, Dhawahir A, Becerra M, Carnero A, Barbacid M. Using cells devoid of RAS proteins as tools for drug discovery. Molecular Carcinogenesis. 48: 1038-47. PMID 19526460 DOI: 10.1002/Mc.20555  0.376
2009 Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nature Reviews. Cancer. 9: 153-66. PMID 19238148 DOI: 10.1038/Nrc2602  0.338
2008 Schuhmacher AJ, Guerra C, Sauzeau V, Cañamero M, Bustelo XR, Barbacid M. A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. The Journal of Clinical Investigation. 118: 2169-79. PMID 18483625 DOI: 10.1172/Jci34385  0.309
2007 Barrière C, Santamaría D, Cerqueira A, Galán J, Martín A, Ortega S, Malumbres M, Dubus P, Barbacid M. Mice thrive without Cdk4 and Cdk2. Molecular Oncology. 1: 72-83. PMID 19383288 DOI: 10.1016/J.Molonc.2007.03.001  0.332
2007 Santamaría D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, Cáceres JF, Dubus P, Malumbres M, Barbacid M. Cdk1 is sufficient to drive the mammalian cell cycle. Nature. 448: 811-5. PMID 17700700 DOI: 10.1038/Nature06046  0.363
2007 Ventura JJ, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M, Pasparakis M, Nebreda AR. p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nature Genetics. 39: 750-8. PMID 17468755 DOI: 10.1038/Ng2037  0.32
2007 Guerra C, Schuhmacher AJ, Cañamero M, Grippo PJ, Verdaguer L, Pérez-Gallego L, Dubus P, Sandgren EP, Barbacid M. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell. 11: 291-302. PMID 17349585 DOI: 10.1016/J.Ccr.2007.01.012  0.33
2007 Malumbres M, Barbacid M. Cell cycle kinases in cancer. Current Opinion in Genetics & Development. 17: 60-5. PMID 17208431 DOI: 10.1016/J.Gde.2006.12.008  0.356
2006 Sansom OJ, Meniel V, Wilkins JA, Cole AM, Oien KA, Marsh V, Jamieson TJ, Guerra C, Ashton GH, Barbacid M, Clarke AR. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 14122-7. PMID 16959882 DOI: 10.1073/Pnas.0604130103  0.324
2006 Tormo D, Ferrer A, Gaffal E, Wenzel J, Basner-Tschakarjan E, Steitz J, Heukamp LC, Gütgemann I, Buettner R, Malumbres M, Barbacid M, Merlino G, Tüting T. Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation. The American Journal of Pathology. 169: 665-72. PMID 16877364 DOI: 10.2353/Ajpath.2006.060017  0.328
2006 Hacker E, Muller HK, Irwin N, Gabrielli B, Lincoln D, Pavey S, Powell MB, Malumbres M, Barbacid M, Hayward N, Walker G. Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Research. 66: 2946-52. PMID 16540642 DOI: 10.1158/0008-5472.Can-05-3196  0.333
2006 Malumbres M, Barbacid M. Is Cyclin D1-CDK4 kinase a bona fide cancer target? Cancer Cell. 9: 2-4. PMID 16413464 DOI: 10.1016/J.Ccr.2005.12.026  0.366
2006 Duensing A, Liu Y, Tseng M, Malumbres M, Barbacid M, Duensing S. Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene. 25: 2943-9. PMID 16331279 DOI: 10.1038/Sj.Onc.1209310  0.344
2005 Barbacid M, Ortega S, Sotillo R, Odajima J, Martín A, Santamaría D, Dubus P, Malumbres M. Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases. Cold Spring Harbor Symposia On Quantitative Biology. 70: 233-40. PMID 16869759 DOI: 10.1101/Sqb.2005.70.005  0.364
2005 Malumbres M, Barbacid M. Mammalian cyclin-dependent kinases. Trends in Biochemical Sciences. 30: 630-41. PMID 16236519 DOI: 10.1016/J.Tibs.2005.09.005  0.361
2005 Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguría A, Zaballos A, Flores JM, Barbacid M, Beach D, Serrano M. Tumour biology: senescence in premalignant tumours. Nature. 436: 642. PMID 16079833 DOI: 10.1038/436642A  0.3
2005 Martín A, Odajima J, Hunt SL, Dubus P, Ortega S, Malumbres M, Barbacid M. Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell. 7: 591-8. PMID 15950907 DOI: 10.1016/J.Ccr.2005.05.006  0.324
2005 Sotillo R, Renner O, Dubus P, Ruiz-Cabello J, Martín-Caballero J, Barbacid M, Carnero A, Malumbres M. Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. Cancer Research. 65: 3846-52. PMID 15867383 DOI: 10.1158/0008-5472.Can-04-4195  0.37
2005 Mijimolle N, Velasco J, Dubus P, Guerra C, Weinbaum CA, Casey PJ, Campuzano V, Barbacid M. Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell. 7: 313-24. PMID 15837621 DOI: 10.1016/J.Ccr.2005.03.004  0.34
2004 Malumbres M, Sotillo R, Santamaría D, Galán J, Cerezo A, Ortega S, Dubus P, Barbacid M. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell. 118: 493-504. PMID 15315761 DOI: 10.1016/J.Cell.2004.08.002  0.338
2003 Guerra C, Mijimolle N, Dhawahir A, Dubus P, Barradas M, Serrano M, Campuzano V, Barbacid M. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell. 4: 111-20. PMID 12957286 DOI: 10.1016/S1535-6108(03)00191-0  0.329
2003 Ortega S, Prieto I, Odajima J, Martín A, Dubus P, Sotillo R, Barbero JL, Malumbres M, Barbacid M. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nature Genetics. 35: 25-31. PMID 12923533 DOI: 10.1038/Ng1232  0.348
2003 Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene. 22: 5261-9. PMID 12917627 DOI: 10.1038/Sj.Onc.1206506  0.308
2003 Malumbres M, Hunt SL, Sotillo R, Martín J, Odajima J, Martín A, Dubus P, Ortega S, Barbacid M. Driving the cell cycle to cancer. Advances in Experimental Medicine and Biology. 532: 1-11. PMID 12908544 DOI: 10.1007/978-1-4615-0081-0_1  0.391
2003 Malumbres M, Barbacid M. RAS oncogenes: the first 30 years. Nature Reviews. Cancer. 3: 459-65. PMID 12778136 DOI: 10.1038/Nrc1097  0.303
2002 Ortega S, Malumbres M, Barbacid M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochimica Et Biophysica Acta. 1602: 73-87. PMID 11960696 DOI: 10.1016/S0304-419X(02)00037-9  0.359
2001 Sotillo R, Dubus P, Martín J, de la Cueva E, Ortega S, Malumbres M, Barbacid M. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. The Embo Journal. 20: 6637-47. PMID 11726500 DOI: 10.1093/Emboj/20.23.6637  0.379
2001 Sotillo R, García JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M. Invasive melanoma in Cdk4-targeted mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 13312-7. PMID 11606789 DOI: 10.1073/Pnas.241338598  0.346
2000 Malumbres M, Ortega S, Barbacid M. Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors. Biological Chemistry. 381: 827-38. PMID 11076015 DOI: 10.1515/Bc.2000.105  0.362
2000 Latres E, Malumbres M, Sotillo R, Martín J, Ortega S, Martín-Caballero J, Flores JM, Cordón-Cardo C, Barbacid M. Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. The Embo Journal. 19: 3496-506. PMID 10880462 DOI: 10.1093/Emboj/19.13.3496  0.351
1998 Rice FL, Albers KM, Davis BM, Silos-Santiago I, Wilkinson GA, LeMaster AM, Ernfors P, Smeyne RJ, Aldskogius H, Phillips HS, Barbacid M, DeChiara TM, Yancopoulos GD, Dunne CE, Fundin BT. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Developmental Biology. 198: 57-81. PMID 9640332 DOI: 10.1006/Dbio.1998.8861  0.336
1998 Fischer KD, Kong YY, Nishina H, Tedford K, Marengère LE, Kozieradzki I, Sasaki T, Starr M, Chan G, Gardener S, Nghiem MP, Bouchard D, Barbacid M, Bernstein A, Penninger JM. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Current Biology : Cb. 8: 554-62. PMID 9601639 DOI: 10.1016/S0960-9822(98)70224-6  0.337
1998 Frisén J, Yates PA, McLaughlin T, Friedman GC, O'Leary DD, Barbacid M. Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 20: 235-43. PMID 9491985 DOI: 10.1016/S0896-6273(00)80452-3  0.592
1997 Silos-Santiago I, Fagan AM, Garber M, Fritzsch B, Barbacid M. Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors. The European Journal of Neuroscience. 9: 2045-56. PMID 9421165 DOI: 10.1111/J.1460-9568.1997.Tb01372.X  0.344
1997 Fundin BT, Silos-Santiago I, Ernfors P, Fagan AM, Aldskogius H, DeChiara TM, Phillips HS, Barbacid M, Yancopoulos GD, Rice FL. Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. Developmental Biology. 190: 94-116. PMID 9331334 DOI: 10.1006/Dbio.1997.8658  0.349
1997 Frisén J, Barbacid M. Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system. Cell and Tissue Research. 290: 209-15. PMID 9321682 DOI: 10.1007/S004410050925  0.321
1997 Fritzsch B, Sarai PA, Barbacid M, Silos-Santiago I. Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 15: 563-76. PMID 9263033 DOI: 10.1016/S0736-5748(96)00111-6  0.329
1997 Rosa JL, Barbacid M. A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70. Oncogene. 15: 1-6. PMID 9233772 DOI: 10.1038/Sj.Onc.1201170  0.305
1997 Park S, Frisén J, Barbacid M. Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. The Embo Journal. 16: 3106-14. PMID 9214628 DOI: 10.1093/Emboj/16.11.3106  0.325
1997 Yan Y, Frisén J, Lee MH, Massagué J, Barbacid M. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes & Development. 11: 973-83. PMID 9136926 DOI: 10.1101/Gad.11.8.973  0.332
1996 Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaró S, Barbacid M. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. The Embo Journal. 15: 4262-73. PMID 8861955 DOI: 10.1002/J.1460-2075.1996.Tb00801.X  0.329
1996 Fagan AM, Zhang H, Landis S, Smeyne RJ, Silos-Santiago I, Barbacid M. TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 6208-18. PMID 8815902 DOI: 10.1523/Jneurosci.16-19-06208.1996  0.337
1995 Patel DV, Gordon EM, Schmidt RJ, Weller HN, Young MG, Zahler R, Barbacid M, Carboni JM, Gullo-Brown JL, Hunihan L. Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase. Journal of Medicinal Chemistry. 38: 435-42. PMID 7853336 DOI: 10.1021/Jm00003A006  0.326
1995 Barbacid M. Neurotrophic factors and their receptors. Current Opinion in Cell Biology. 7: 148-55. PMID 7612265 DOI: 10.1016/0955-0674(95)80022-0  0.332
1995 Barbacid M. Structural and functional properties of the TRK family of neurotrophin receptors. Annals of the New York Academy of Sciences. 766: 442-58. PMID 7486690 DOI: 10.1111/J.1749-6632.1995.Tb26693.X  0.33
1995 Manne V, Ricca CS, Brown JG, Tuomari AV, Yan N, Patel D, Schmidt R, Lynch MJ, Ciosek CP, Carboni JM, Robinson S, Gordon EM, Barbacid M, Seizinger BR, Biller SA. Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase Drug Development Research. 34: 121-137. DOI: 10.1002/Ddr.430340205  0.346
1994 Lamballe F, Smeyne RJ, Barbacid M. Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 14-28. PMID 8283230 DOI: 10.1523/Jneurosci.14-01-00014.1994  0.321
1994 Klein R, Silos-Santiago I, Smeyne RJ, Lira SA, Brambilla R, Bryant S, Zhang L, Snider WD, Barbacid M. Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature. 368: 249-51. PMID 8145824 DOI: 10.1038/368249A0  0.727
1994 Smeyne RJ, Klein R, Schnapp A, Long LK, Bryant S, Lewin A, Lira SA, Barbacid M. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature. 368: 246-9. PMID 8145823 DOI: 10.1038/368246A0  0.34
1994 Sánchez MP, Tapley P, Saini SS, He B, Pulido D, Barbacid M. Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain. Proceedings of the National Academy of Sciences of the United States of America. 91: 1819-23. PMID 8127887 DOI: 10.1073/Pnas.91.5.1819  0.358
1994 Barbacid M. The Trk family of neurotrophin receptors. Journal of Neurobiology. 25: 1386-403. PMID 7852993 DOI: 10.1002/Neu.480251107  0.371
1993 Klein R, Smeyne RJ, Wurst W, Long LK, Auerbach BA, Joyner AL, Barbacid M. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell. 75: 113-22. PMID 8402890 DOI: 10.1016/S0092-8674(05)80088-1  0.374
1993 Lamballe F, Tapley P, Barbacid M. trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. The Embo Journal. 12: 3083-94. PMID 8344249 DOI: 10.1002/J.1460-2075.1993.Tb05977.X  0.341
1993 Suen KL, Bustelo XR, Pawson T, Barbacid M. Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Molecular and Cellular Biology. 13: 5500-12. PMID 7689150 DOI: 10.1128/Mcb.13.9.5500  0.392
1993 Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, Greene LA, Barbacid M, Yancopoulos GD. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron. 10: 137-49. PMID 7679912 DOI: 10.1016/0896-6273(93)90306-C  0.313
1992 Bustelo XR, Barbacid M. Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells. Science (New York, N.Y.). 256: 1196-9. PMID 1375396 DOI: 10.1126/Science.256.5060.1196  0.345
1992 Klein R, Lamballe F, Bryant S, Barbacid M. The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron. 8: 947-56. PMID 1375038 DOI: 10.1016/0896-6273(92)90209-V  0.371
1992 Pulido D, Campuzano S, Koda T, Modolell J, Barbacid M. Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule. The Embo Journal. 11: 391-404. PMID 1371458 DOI: 10.1002/J.1460-2075.1992.Tb05067.X  0.339
1992 Bustelo XR, Ledbetter JA, Barbacid M. Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature. 356: 68-71. PMID 1311423 DOI: 10.1038/356068A0  0.361
1992 Jing S, Tapley P, Barbacid M. Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron. 9: 1067-79. PMID 1281417 DOI: 10.1016/0896-6273(92)90066-M  0.339
1991 Garlick DS, Sukumar S, Barbacid M, Petit D, Hamer PJ, Leav I, Lavecchio JA, Trimpe KL, Carney WP. Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas. Hybridoma. 10: 95-102. PMID 2032737 DOI: 10.1089/Hyb.1991.10.95  0.355
1991 Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell. 65: 189-97. PMID 1849459 DOI: 10.1016/0092-8674(91)90419-Y  0.344
1991 Barbacid M, Lamballe F, Pulido D, Klein R. The trk family of tyrosine protein kinase receptors. Biochimica Et Biophysica Acta. 1072: 115-27. PMID 1751544 DOI: 10.1016/0304-419X(91)90010-I  0.311
1991 Lamballe F, Klein R, Barbacid M. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell. 66: 967-79. PMID 1653651 DOI: 10.1016/0092-8674(91)90442-2  0.373
1991 Klein R, Nanduri V, Jing SA, Lamballe F, Tapley P, Bryant S, Cordon-Cardo C, Jones KR, Reichardt LF, Barbacid M. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell. 66: 395-403. PMID 1649702 DOI: 10.1016/0092-8674(91)90628-C  0.338
1990 Sukumar S, Barbacid M. Specific patterns of oncogene activation in transplacentally induced tumors. Proceedings of the National Academy of Sciences of the United States of America. 87: 718-22. PMID 2405388 DOI: 10.1073/Pnas.87.2.718  0.338
1990 Martin-Zanca D, Barbacid M, Parada LF. Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes & Development. 4: 683-94. PMID 2379826 DOI: 10.1101/Gad.4.5.683  0.354
1990 Kumar R, Sukumar S, Barbacid M. Activation of ras oncogenes preceding the onset of neoplasia. Science (New York, N.Y.). 248: 1101-4. PMID 2188364 DOI: 10.1126/Science.2188364  0.317
1990 Coulier F, Kumar R, Ernst M, Klein R, Martin-Zanca D, Barbacid M. Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain. Molecular and Cellular Biology. 10: 4202-10. PMID 1695324 DOI: 10.1128/MCB.10.8.4202  0.679
1989 Klein R, Parada LF, Coulier F, Barbacid M. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. The Embo Journal. 8: 3701-9. PMID 2555172  0.68
1988 Sukumar S, Carney WP, Barbacid M. Independent molecular pathways in initiation and loss of hormone responsiveness of breast carcinomas. Science (New York, N.Y.). 240: 524-6. PMID 3282307 DOI: 10.1126/Science.3282307  0.304
1987 Mitra G, Martin-Zanca D, Barbacid M. Identification and biochemical characterization of p70TRK, product of the human TRK oncogene. Proceedings of the National Academy of Sciences of the United States of America. 84: 6707-11. PMID 3477801 DOI: 10.1073/Pnas.84.19.6707  0.366
1986 Zarbl H, Sukumar S, Arthur AL, Martin-Zanca D, Barbacid M. Activation of H-ras-1 oncogenes by chemical carcinogens. Basic Life Sciences. 38: 385-97. PMID 3017289 DOI: 10.1007/978-1-4615-9462-8_42  0.359
1986 Martin-Zanca D, Hughes SH, Barbacid M. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319: 743-8. PMID 2869410 DOI: 10.1038/319743A0  0.339
1985 Pulciani S, Santos E, Long LK, Sorrentino V, Barbacid M. ras gene Amplification and malignant transformation. Molecular and Cellular Biology. 5: 2836-41. PMID 3915535 DOI: 10.1128/Mcb.5.10.2836  0.347
1985 Zarbl H, Sukumar S, Martin-Zanca D, Santos E, Barbacid M. Molecular assays for detection of ras oncogenes in human and animal tumors. Carcinogenesis; a Comprehensive Survey. 9: 1-16. PMID 3902219 DOI: 10.1007/978-1-4612-5008-1_40  0.358
1984 Santos E, Martin-Zanca D, Reddy EP, Pierotti MA, Della Porta G, Barbacid M. Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science (New York, N.Y.). 223: 661-4. PMID 6695174 DOI: 10.1126/Science.6695174  0.34
1984 Lacal JC, Santos E, Notario V, Barbacid M, Yamazaki S, Kung H, Seamans C, McAndrew S, Crowl R. Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins. Proceedings of the National Academy of Sciences of the United States of America. 81: 5305-9. PMID 6089191 DOI: 10.1073/Pnas.81.17.5305  0.333
1983 Sukumar S, Notario V, Martin-Zanca D, Barbacid M. Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature. 306: 658-61. PMID 6318112 DOI: 10.1038/306658A0  0.315
1983 Santos E, Reddy EP, Pulciani S, Feldmann RJ, Barbacid M. Spontaneous activation of a human proto-oncogene. Proceedings of the National Academy of Sciences of the United States of America. 80: 4679-83. PMID 6308640 DOI: 10.1073/Pnas.80.15.4679  0.322
1982 McBride OW, Swan DC, Santos E, Barbacid M, Tronick SR, Aaronson SA. Localization of the normal allele of T24 human bladder carcinoma oncogene to chromosome 11. Nature. 300: 773-4. PMID 7177197 DOI: 10.1038/300773A0  0.312
1981 Barbacid M, Breitman ML, Lauver AV, Long LK, Vogt PK. The transformation-specific proteins of avian (Fujinami and PRC-II) and feline (Synder--Theilen and Gardner--Arnstein) sarcoma viruses are immunologically related. Virology. 110: 411-9. PMID 6164154 DOI: 10.1016/0042-6822(81)90071-4  0.307
1980 Barbacid M, Beemon K, Devare SG. Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus. Proceedings of the National Academy of Sciences of the United States of America. 77: 5158-62. PMID 6254060 DOI: 10.1073/Pnas.77.9.5158  0.349
1975 Barbacid M, Fresno M, Vazquez D. Inhibitors of polypeptide elongation on yeast polysomes. The Journal of Antibiotics. 28: 453-62. PMID 1097384 DOI: 10.7164/Antibiotics.28.453  0.472
1975 Barbacid M, Contreras A, Vazquez D. The mode of action of griseoviridin at the ribosome level. Biochimica Et Biophysica Acta. 395: 347-54. PMID 1096949 DOI: 10.1016/0005-2787(75)90206-3  0.474
1975 Barbacid M, Vazquez D. Ribosome changes during translation. Journal of Molecular Biology. 93: 449-63. PMID 1095764 DOI: 10.1016/0022-2836(75)90239-9  0.518
1974 Barbacid M, Vazquez D. Preparation of (3H)anisomycin and (3H)gougerotin: binding to eukaryotic ribosomes. Methods in Enzymology. 30: 426-39. PMID 4604931 DOI: 10.1016/0076-6879(74)30043-2  0.532
1974 Contreras A, Barbacid M, Vazquez D. Binding to ribosomes and mode of action of chloramphenicol analogues. Biochimica Et Biophysica Acta. 349: 376-88. PMID 4601418 DOI: 10.1016/0005-2787(74)90124-5  0.472
1974 Barbacid M, Vazquez D. (3H)anisomycin binding to eukaryotic ribosomes. Journal of Molecular Biology. 84: 603-23. PMID 4601392 DOI: 10.1016/0022-2836(74)90119-3  0.536
1974 Barbacid M, Vazquez D. (G-3H)gougerotin binding to ribosomes. Heterogeneity of eukaryotic ribosomes. European Journal of Biochemistry / Febs. 44: 445-53. PMID 4600364 DOI: 10.1111/J.1432-1033.1974.Tb03502.X  0.527
1974 Barbacid M, Vazquez D. Binding of (acetyl-14C)trichodermin to the peptidyl transferase centre of eukaryotic ribosomes. European Journal of Biochemistry / Febs. 44: 437-44. PMID 4599837 DOI: 10.1111/J.1432-1033.1974.Tb03501.X  0.528
1973 Barbacid M, Vazquez D. Preparation of pure (3H)anisomycin by tritium exchange labeling. Analytical Biochemistry. 56: 16-25. PMID 4764685 DOI: 10.1016/0003-2697(73)90164-4  0.515
1973 Carrasco L, Barbacid M, Vazquez D. The trichodermin group of antibiotics, inhibitors of peptide bond formation by eukaryotic ribosomes. Biochimica Et Biophysica Acta. 312: 368-76. PMID 4579233 DOI: 10.1016/0005-2787(73)90381-X  0.585
Show low-probability matches.