Ralph A. Nixon, MD - Publications

Affiliations: 
Psychiatry New York University, New York, NY, United States 
Area:
neurodegeneration, Alzheimer's disease, Autophagy

247 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ying J, Sato Y, Im E, Berg M, Bordi M, Darji S, Kumar A, Mohan PS, Bandyopadhyay U, Diaz A, Maria Cuervo A, Nixon RA. Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31043483 DOI: 10.1523/JNEUROSCI.0578-19.2019  0.52
2018 Ju-Hyun L, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA. Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. Autophagy. PMID 30269645 DOI: 10.1080/15548627.2018.1528812  0.36
2017 Colacurcio DJ, Pensalfini A, Jiang Y, Nixon RA. Dysfunction of Autophagy and Endosomal-lysosomal Pathways: Roles in Pathogenesis of Down Syndrome and Alzheimer's Disease. Free Radical Biology & Medicine. PMID 28988799 DOI: 10.1016/j.freeradbiomed.2017.10.001  0.64
2017 Yang DS, Stavrides P, Kumar A, Jiang Y, Mohan PS, Ohno M, Dobrenis K, Davidson CD, Saito M, Pawlik M, Huo C, Walkley SU, Nixon RA. Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice. Human Molecular Genetics. PMID 28062666 DOI: 10.1093/hmg/ddx001  0.64
2016 Bordi M, Berg MJ, Mohan PS, Peterhoff CM, Alldred MJ, Che S, Ginsberg SD, Nixon RA. Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy. 1-17. PMID 27813694 DOI: 10.1080/15548627.2016.1239003  0.48
2016 Colacurcio DJ, Nixon RA. Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Research Reviews. PMID 27197071 DOI: 10.1016/j.arr.2016.05.004  1
2016 Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiology of Aging. 39: 90-98. PMID 26923405 DOI: 10.1016/j.neurobiolaging.2015.11.013  1
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Nixon RA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.64
2016 Rao MV, Campbell J, Palaniappan A, Kumar A, Nixon RA. Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice. Journal of Neurochemistry. PMID 26756888 DOI: 10.1111/jnc.13536  0.36
2015 Hamlett E, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AE. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Current Alzheimer Research. PMID 26391050  0.32
2015 Lee JH, McBrayer MK, Wolfe DM, Haslett LJ, Kumar A, Sato Y, Lie PP, Mohan P, Coffey EE, Kompella U, Mitchell CH, Lloyd-Evans E, Nixon RA. Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification. Cell Reports. PMID 26299959 DOI: 10.1016/j.celrep.2015.07.050  1
2015 Yuan A, Hassinger L, Rao MV, Julien JP, Miller CC, Nixon RA. Dissociation of Axonal Neurofilament Content from Its Transport Rate. Plos One. 10: e0133848. PMID 26208164 DOI: 10.1371/journal.pone.0133848  1
2015 Yuan A, Sershen H, Veeranna, Basavarajappa BS, Kumar A, Hashim A, Berg M, Lee JH, Sato Y, Rao MV, Mohan PS, Dyakin V, Julien JP, Lee VM, Nixon RA. Functions of neurofilaments in synapses. Molecular Psychiatry. 20: 915. PMID 26201270 DOI: 10.1038/mp.2015.99  0.36
2015 Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA. Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease. Molecular Psychiatry. PMID 26194181 DOI: 10.1038/mp.2015.97  0.36
2015 Yuan A, Sershen H, Veeranna, Basavarajappa BS, Kumar A, Hashim A, Berg M, Lee JH, Sato Y, Rao MV, Mohan PS, Dyakin V, Julien JP, Lee VM, Nixon RA. Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo. Molecular Psychiatry. PMID 25869803 DOI: 10.1038/mp.2015.45  0.36
2015 Xu W, Fitzgerald S, Nixon RA, Levy E, Wilson DA. Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease. Experimental Neurology. 264: 82-91. PMID 25500142 DOI: 10.1016/j.expneurol.2014.12.008  0.48
2015 Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA, Rao MV, Lam W, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O'Kane CJ, Rubinsztein DC. Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity. Cell Death and Differentiation. 22: 433-44. PMID 25257175 DOI: 10.1038/cdd.2014.151  0.36
2014 Yang DS, Stavrides P, Saito M, Kumar A, Rodriguez-Navarro JA, Pawlik M, Huo C, Walkley SU, Saito M, Cuervo AM, Nixon RA. Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits. Brain : a Journal of Neurology. 137: 3300-18. PMID 25270989 DOI: 10.1093/brain/awu278  1
2014 Xu W, Lopez-Guzman M, Schoen C, Fitzgerald S, Lauer SL, Nixon RA, Levy E, Wilson DA. Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease. Plos One. 9: e106431. PMID 25181487 DOI: 10.1371/journal.pone.0106431  0.48
2014 Xue X, Wang LR, Sato Y, Jiang Y, Berg M, Yang DS, Nixon RA, Liang XJ. Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease. Nano Letters. 14: 5110-7. PMID 25115676 DOI: 10.1021/nl501839q  1
2014 Rao MV, McBrayer MK, Campbell J, Kumar A, Hashim A, Sershen H, Stavrides PH, Ohno M, Hutton M, Nixon RA. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9222-34. PMID 25009256 DOI: 10.1523/JNEUROSCI.1132-14.2014  1
2014 Nixon RA. Alzheimer neurodegeneration, autophagy, and Abeta secretion: the ins and outs (comment on DOI 10.1002/bies.201400002). Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 547. PMID 24819351 DOI: 10.1002/bies.201400064  1
2014 Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, et al. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. Human Molecular Genetics. 23: 3975-89. PMID 24619358 DOI: 10.1093/hmg/ddu112  1
2013 McBrayer M, Nixon RA. Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime. Biochemical Society Transactions. 41: 1495-502. PMID 24256243 DOI: 10.1042/BST20130201  1
2013 Annunziata I, Patterson A, Helton D, Hu H, Moshiach S, Gomero E, Nixon R, D'Azzo A. Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis Nature Communications. 4. PMID 24225533 DOI: 10.1038/ncomms3734  1
2013 Yuan A, Kumar A, Sasaki T, Duff K, Nixon RA. Global axonal transport rates are unaltered in htau mice in vivo. Journal of Alzheimer's Disease : Jad. 37: 579-86. PMID 23948900 DOI: 10.3233/JAD-130671  1
2013 Nixon RA. The role of autophagy in neurodegenerative disease. Nature Medicine. 19: 983-97. PMID 23921753 DOI: 10.1038/nm.3232  1
2013 Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA. Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. The European Journal of Neuroscience. 37: 1949-61. PMID 23773064 DOI: 10.1111/ejn.12169  1
2013 Subbanna S, Shivakumar M, Umapathy NS, Saito M, Mohan PS, Kumar A, Nixon RA, Verin AD, Psychoyos D, Basavarajappa BS. G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain. Neurobiology of Disease. 54: 475-85. PMID 23396011 DOI: 10.1016/j.nbd.2013.01.022  1
2013 Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM. Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiology of Aging. 34: 137-45. PMID 22608241 DOI: 10.1016/j.neurobiolaging.2012.04.007  1
2012 Rao MV, Yuan A, Campbell J, Kumar A, Nixon RA. The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network. Plos One. 7: e44320. PMID 23028520 DOI: 10.1371/journal.pone.0044320  1
2012 Nixon RA, Yang DS. Autophagy and neuronal cell death in neurological disorders. Cold Spring Harbor Perspectives in Biology. 4. PMID 22983160 DOI: 10.1101/cshperspect.a008839  1
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Nixon RA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490  0.32
2012 Yuan A, Rao MV, Veeranna, Nixon RA. Neurofilaments at a glance. Journal of Cell Science. 125: 3257-63. PMID 22956720 DOI: 10.1242/jcs.104729  1
2012 Ihara Y, Morishima-Kawashima M, Nixon R. The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2. PMID 22908190 DOI: 10.1101/cshperspect.a006361  1
2012 Yuan A, Sasaki T, Kumar A, Peterhoff CM, Rao MV, Liem RK, Julien JP, Nixon RA. Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8501-8. PMID 22723690 DOI: 10.1523/JNEUROSCI.1081-12.2012  1
2012 Schmidt SD, Mazzella MJ, Nixon RA, Mathews PM. Aβ measurement by enzyme-linked immunosorbent assay. Methods in Molecular Biology (Clifton, N.J.). 849: 507-27. PMID 22528112 DOI: 10.1007/978-1-61779-551-0_34  1
2012 Schmidt SD, Nixon RA, Mathews PM. Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ. Methods in Molecular Biology (Clifton, N.J.). 849: 493-506. PMID 22528111 DOI: 10.1007/978-1-61779-551-0_33  1
2012 Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA, Mathews PM. Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiology of Aging. 33: 1125.e9-18. PMID 22206846 DOI: 10.1016/j.neurobiolaging.2011.11.023  1
2011 Wesson DW, Borkowski AH, Landreth GE, Nixon RA, Levy E, Wilson DA. Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15962-71. PMID 22049439 DOI: 10.1523/JNEUROSCI.2085-11.2011  1
2011 Lee S, Sato Y, Nixon RA. Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy. Autophagy. 7: 1562-3. PMID 22024748 DOI: 10.4161/auto.7.12.17956  1
2011 Ginsberg SD, Mufson EJ, Alldred MJ, Counts SE, Wuu J, Nixon RA, Che S. Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. Journal of Chemical Neuroanatomy. 42: 102-10. PMID 21669283 DOI: 10.1016/j.jchemneu.2011.05.012  1
2011 Lee S, Sato Y, Nixon RA. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7817-30. PMID 21613495 DOI: 10.1523/JNEUROSCI.6412-10.2011  1
2011 Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Nixon RA, et al. Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy. 7: 788-9. PMID 21464620 DOI: 10.4161/auto.7.7.15596  1
2011 Wesson DW, Nixon RA, Levy E, Wilson DA. Mechanisms of neural and behavioral dysfunction in Alzheimer's disease. Molecular Neurobiology. 43: 163-79. PMID 21424679 DOI: 10.1007/s12035-011-8177-1  1
2011 Rao MV, Mohan PS, Kumar A, Yuan A, Montagna L, Campbell J, Veeranna, Espreafico EM, Julien JP, Nixon RA. The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons. Plos One. 6: e17087. PMID 21359212 DOI: 10.1371/journal.pone.0017087  1
2011 Nixon RA, Yang DS. Autophagy failure in Alzheimer's disease--locating the primary defect. Neurobiology of Disease. 43: 38-45. PMID 21296668 DOI: 10.1016/j.nbd.2011.01.021  1
2011 Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Nixon RA, et al. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain : a Journal of Neurology. 134: 258-77. PMID 21186265 DOI: 10.1093/brain/awq341  1
2011 Veeranna, Yang DS, Lee JH, Vinod KY, Stavrides P, Amin ND, Pant HC, Nixon RA. Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiology of Aging. 32: 2016-29. PMID 20031277 DOI: 10.1016/j.neurobiolaging.2009.12.001  1
2010 Rubinsztein DC, Nixon RA. Rapamycin induces autophagic flux in neurons. Proceedings of the National Academy of Sciences of the United States of America. 107: E181; author reply E. PMID 21115811 DOI: 10.1073/pnas.1014633107  1
2010 Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14946-54. PMID 21068297 DOI: 10.1523/JNEUROSCI.4305-10.2010  1
2010 Kaur G, Mohan P, Pawlik M, DeRosa S, Fajiculay J, Che S, Grubb A, Ginsberg SD, Nixon RA, Levy E. Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy. The American Journal of Pathology. 177: 2256-67. PMID 20889561 DOI: 10.2353/ajpath.2010.100461  1
2010 Ginsberg SD, Mufson EJ, Counts SE, Wuu J, Alldred MJ, Nixon RA, Che S. Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 22: 631-9. PMID 20847427 DOI: 10.3233/JAD-2010-101080  1
2010 Ginsberg SD, Alldred MJ, Counts SE, Cataldo AM, Neve RL, Jiang Y, Wuu J, Chao MV, Mufson EJ, Nixon RA, Che S. Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biological Psychiatry. 68: 885-93. PMID 20655510 DOI: 10.1016/j.biopsych.2010.05.030  1
2010 Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell. 141: 1146-58. PMID 20541250 DOI: 10.1016/j.cell.2010.05.008  1
2010 Rothenberg C, Srinivasan D, Mah L, Kaushik S, Peterhoff CM, Ugolino J, Fang S, Cuervo AM, Nixon RA, Monteiro MJ. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Human Molecular Genetics. 19: 3219-32. PMID 20529957 DOI: 10.1093/hmg/ddq231  1
2010 Wesson DW, Wilson DA, Nixon RA. Should olfactory dysfunction be used as a biomarker of Alzheimer's disease? Expert Review of Neurotherapeutics. 10: 633-5. PMID 20420483 DOI: 10.1586/ern.10.33  1
2010 Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim TW. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2783-94. PMID 20354142 DOI: 10.1096/fj.09-146357  1
2010 Tizon B, Sahoo S, Yu H, Gauthier S, Kumar AR, Mohan P, Figliola M, Pawlik M, Grubb A, Uchiyama Y, Bandyopadhyay U, Cuervo AM, Nixon RA, Levy E. Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. Plos One. 5: e9819. PMID 20352108 DOI: 10.1371/journal.pone.0009819  1
2010 Dyakin VV, Chen Y, Branch CA, Veeranna, Yuan A, Rao M, Kumar A, Peterhoff CM, Nixon RA. The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models. Neuroimage. 51: 1098-105. PMID 20226865 DOI: 10.1016/j.neuroimage.2010.03.013  1
2010 Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proceedings of the National Academy of Sciences of the United States of America. 107: 1630-5. PMID 20080541 DOI: 10.1073/pnas.0908953107  1
2010 Wesson DW, Levy E, Nixon RA, Wilson DA. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 505-14. PMID 20071513 DOI: 10.1523/JNEUROSCI.4622-09.2010  1
2009 Yuan A, Sasaki T, Rao MV, Kumar A, Kanumuri V, Dunlop DS, Liem RK, Nixon RA. Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11316-29. PMID 19741138 DOI: 10.1523/JNEUROSCI.1942-09.2009  1
2009 Choi JH, Berger JD, Mazzella MJ, Morales-Corraliza J, Cataldo AM, Nixon RA, Ginsberg SD, Levy E, Mathews PM. Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. Journal of Neurochemistry. 110: 1818-27. PMID 19619138 DOI: 10.1111/j.1471-4159.2009.06277.x  1
2009 Mi W, Jung SS, Yu H, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E. Complexes of amyloid-beta and cystatin C in the human central nervous system. Journal of Alzheimer's Disease : Jad. 18: 273-80. PMID 19584436 DOI: 10.3233/JAD-2009-1147  1
2009 Basavarajappa BS, Nixon RA, Arancio O. Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini Reviews in Medicinal Chemistry. 9: 448-62. PMID 19356123 DOI: 10.2174/138955709787847921  1
2009 Yang DS, Lee JH, Nixon RA. Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases. Methods in Enzymology. 453: 111-44. PMID 19216904 DOI: 10.1016/S0076-6879(08)04006-8  1
2009 Wilson DA, Nixon RA. Sniffing out a function for prion proteins. Nature Neuroscience. 12: 7-8. PMID 19107142 DOI: 10.1038/nn0109-7  1
2009 Chen Y, Dyakin VV, Branch CA, Ardekani B, Yang D, Guilfoyle DN, Peterson J, Peterhoff C, Ginsberg SD, Cataldo AM, Nixon RA. In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiology of Aging. 30: 1453-65. PMID 18180075 DOI: 10.1016/j.neurobiolaging.2007.11.026  1
2008 Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12798-807. PMID 19036972 DOI: 10.1523/JNEUROSCI.4101-08.2008  1
2008 Rao MV, Mohan PS, Peterhoff CM, Yang DS, Schmidt SD, Stavrides PH, Campbell J, Chen Y, Jiang Y, Paskevich PA, Cataldo AM, Haroutunian V, Nixon RA. Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12241-54. PMID 19020018 DOI: 10.1523/JNEUROSCI.4119-08.2008  1
2008 Veeranna, Lee JH, Pareek TK, Jaffee H, Boland B, Vinod KY, Amin N, Kulkarni AB, Pant HC, Nixon RA. Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. Journal of Neurochemistry. 107: 35-49. PMID 18715269 DOI: 10.1111/j.1471-4159.2008.05547.x  1
2008 Yang DS, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M, Levy E, Cataldo AM, Nixon RA. Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. The American Journal of Pathology. 173: 665-81. PMID 18688038 DOI: 10.2353/ajpath.2008.071176  1
2008 Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 118: 2796-807. PMID 18596919 DOI: 10.1172/JCI34254  1
2008 Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6926-37. PMID 18596167 DOI: 10.1523/JNEUROSCI.0800-08.2008  1
2008 Cataldo AM, Mathews PM, Boiteau AB, Hassinger LC, Peterhoff CM, Jiang Y, Mullaney K, Neve RL, Gruenberg J, Nixon RA. Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. The American Journal of Pathology. 173: 370-84. PMID 18535180 DOI: 10.2353/ajpath.2008.071053  1
2008 Azmitia EC, Nixon R. Dystrophic serotonergic axons in neurodegenerative diseases. Brain Research. 1217: 185-94. PMID 18502405 DOI: 10.1016/j.brainres.2008.03.060  1
2008 Nixon RA, Yang DS, Lee JH. Neurodegenerative lysosomal disorders: a continuum from development to late age. Autophagy. 4: 590-9. PMID 18497567  1
2008 Yuan A, Kumar A, Peterhoff C, Duff K, Nixon RA. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1682-7. PMID 18272688 DOI: 10.1523/JNEUROSCI.5242-07.2008  1
2007 Nixon RA. Autophagy, amyloidogenesis and Alzheimer disease. Journal of Cell Science. 120: 4081-91. PMID 18032783 DOI: 10.1242/jcs.019265  1
2007 Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nature Genetics. 39: 1440-2. PMID 18026100 DOI: 10.1038/ng.2007.29  1
2007 Battaglia F, Wang HY, Ghilardi MF, Gashi E, Quartarone A, Friedman E, Nixon RA. Cortical plasticity in Alzheimer's disease in humans and rodents. Biological Psychiatry. 62: 1405-12. PMID 17651702 DOI: 10.1016/j.biopsych.2007.02.027  1
2007 Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. Journal of Neurochemistry. 102: 619-26. PMID 17630980 DOI: 10.1111/j.1471-4159.2007.04587.x  1
2007 Falangola MF, Dyakin VV, Lee SP, Bogart A, Babb JS, Duff K, Nixon R, Helpern JA. Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease. Nmr in Biomedicine. 20: 343-51. PMID 17451178 DOI: 10.1002/nbm.1163  1
2007 Cataldo AM, Nixon RA. Neuronal Protein Trafficking in Alzheimer's Disease and Niemann-Pick Type C Disease Protein Trafficking in Neurons. 391-411. DOI: 10.1016/B978-012369437-9/50025-6  1
2006 Yuan A, Rao MV, Sasaki T, Chen Y, Kumar A, Veeranna, Liem RK, Eyer J, Peterson AC, Julien JP, Nixon RA. Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10006-19. PMID 17005864 DOI: 10.1523/JNEUROSCI.2580-06.2006  1
2006 Boland B, Nixon RA. Neuronal macroautophagy: from development to degeneration. Molecular Aspects of Medicine. 27: 503-19. PMID 16999991 DOI: 10.1016/j.mam.2006.08.009  1
2006 Liang J, Yin C, Doong H, Fang S, Peterhoff C, Nixon RA, Monteiro MJ. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. Journal of Cell Science. 119: 4011-24. PMID 16968747 DOI: 10.1242/jcs.03163  1
2006 Nixon RA, Cataldo AM. Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 9: 277-89. PMID 16914867  1
2006 Butler D, Nixon RA, Bahr BA. Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases. Autophagy. 2: 234-7. PMID 16874061  1
2006 Nixon RA. Autophagy in neurodegenerative disease: friend, foe or turncoat? Trends in Neurosciences. 29: 528-35. PMID 16859759 DOI: 10.1016/j.tins.2006.07.003  1
2006 Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 51: 29-42. PMID 16815330 DOI: 10.1016/j.neuron.2006.05.022  1
2006 Yuan A, Nixon RA, Rao MV. Deleting the phosphorylated tail domain of the neurofilament heavy subunit does not alter neurofilament transport rate in vivo. Neuroscience Letters. 393: 264-8. PMID 16266786 DOI: 10.1016/j.neulet.2005.10.029  1
2005 Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, Stefanis L, Tolkovsky A. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy. 1: 11-22. PMID 16874045  1
2005 Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, ... ... Nixon RA, et al. Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. The Journal of Cell Biology. 171: 87-98. PMID 16203860 DOI: 10.1083/jcb.200505082  1
2005 de Grey AD, Alvarez PJ, Brady RO, Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR. Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Research Reviews. 4: 315-38. PMID 16040282 DOI: 10.1016/j.arr.2005.03.008  1
2005 Schmidt SD, Nixon RA, Mathews PM. ELISA method for measurement of amyloid-beta levels. Methods in Molecular Biology (Clifton, N.J.). 299: 279-97. PMID 15980612  1
2005 Schmidt SD, Jiang Y, Nixon RA, Mathews PM. Tissue processing prior to protein analysis and amyloid-beta quantitation. Methods in Molecular Biology (Clifton, N.J.). 299: 267-78. PMID 15980611  1
2005 Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, et al. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proceedings of the National Academy of Sciences of the United States of America. 102: 8972-7. PMID 15951428 DOI: 10.1073/pnas.0500940102  1
2005 Falangola MF, Lee SP, Nixon RA, Duff K, Helpern JA. Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochemical Research. 30: 201-5. PMID 15895823 DOI: 10.1007/s11064-004-2442-x  1
2005 Falangola MF, Ardekani BA, Lee SP, Babb JS, Bogart A, Dyakin VV, Nixon R, Duff K, Helpern JA. Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology. Journal of Neuroscience Methods. 144: 91-7. PMID 15848243 DOI: 10.1016/j.jneumeth.2004.10.012  1
2005 Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. Journal of Neuropathology and Experimental Neurology. 64: 113-22. PMID 15751225  1
2005 Nixon RA. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiology of Aging. 26: 373-82. PMID 15639316 DOI: 10.1016/j.neurobiolaging.2004.09.018  1
2004 Carter TL, Verdile G, Groth D, Bogush A, Thomas S, Shen P, Fraser PE, Mathews P, Nixon RA, Ehrlich ME, Kwok JB, St George-Hyslop P, Schofield P, Li Y, Yang A, et al. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Disease and Associated Disorders. 18: 261-3. PMID 15592142  1
2004 Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, Mercken M, Mehta PD, Buxbaum J, Haroutunian V, Nixon RA. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiology of Aging. 25: 1263-72. PMID 15465622 DOI: 10.1016/j.neurobiolaging.2004.02.027  1
2004 Lee SP, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 52: 538-44. PMID 15334572 DOI: 10.1002/mrm.20196  1
2004 Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa BS, Peterhoff C, Cataldo A, Rudnicki A, Amin N, Li BS, Pant HC, Hungund BL, Arancio O, Nixon RA. Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. The American Journal of Pathology. 165: 795-805. PMID 15331404 DOI: 10.1016/S0002-9440(10)63342-1  1
2004 Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. Journal of Neuropathology and Experimental Neurology. 63: 821-30. PMID 15330337  1
2004 Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. The International Journal of Biochemistry & Cell Biology. 36: 2531-40. PMID 15325590 DOI: 10.1016/j.biocel.2004.05.010  1
2004 Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, et al. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of Neurochemistry. 90: 1011-8. PMID 15287908 DOI: 10.1111/j.1471-4159.2004.02532.x  1
2004 Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V, Schmidt SD, Nixon RA, Frangione B, Levy E. Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiology of Aging. 25: 1033-43. PMID 15212828 DOI: 10.1016/j.neurobiolaging.2003.11.006  1
2004 Sadowski M, Pankiewicz J, Scholtzova H, Ji Y, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, Wisniewski T. Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. Journal of Neuropathology and Experimental Neurology. 63: 418-28. PMID 15198121  1
2004 Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B, Duff K, Branch C, Wisniewski T, de Leon MJ, Wolf O, O'Shea J, Nixon RA. MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 51: 794-8. PMID 15065253 DOI: 10.1002/mrm.20038  1
2004 Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. Journal of Neurochemistry. 89: 44-53. PMID 15030388 DOI: 10.1046/j.1471-4159.2003.02298.x  1
2004 Nixon RA. Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up. The American Journal of Pathology. 164: 757-61. PMID 14982829 DOI: 10.1016/S0002-9440(10)63163-X  1
2004 Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD, Nixon RA, Levy E. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide. Journal of Molecular Neuroscience : Mn. 22: 13-8. PMID 14742906 DOI: 10.1385/JMN:22:1-2:13  1
2003 Rao MV, Campbell J, Yuan A, Kumar A, Gotow T, Uchiyama Y, Nixon RA. The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate. The Journal of Cell Biology. 163: 1021-31. PMID 14662746 DOI: 10.1083/jcb.200308076  1
2003 Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, et al. In vivo reduction of amyloid-beta by a mutant copper transporter. Proceedings of the National Academy of Sciences of the United States of America. 100: 14193-8. PMID 14617772 DOI: 10.1073/pnas.2332851100  1
2003 Yuan A, Rao MV, Kumar A, Julien JP, Nixon RA. Neurofilament transport in vivo minimally requires hetero-oligomer formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9452-8. PMID 14561875  1
2003 Nixon RA. The calpains in aging and aging-related diseases. Ageing Research Reviews. 2: 407-18. PMID 14522243 DOI: 10.1016/S1568-1637(03)00029-1  1
2003 Battaglia F, Trinchese F, Liu S, Walter S, Nixon RA, Arancio O. Calpain inhibitors, a treatment for Alzheimer's disease: position paper. Journal of Molecular Neuroscience : Mn. 20: 357-62. PMID 14501020 DOI: 10.1385/JMN:20:3:357  1
2003 Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, Nixon RA. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6788-92. PMID 12890772  1
2003 Mathews PM, Nixon RA. Setback for an Alzheimer's disease vaccine: lessons learned. Neurology. 61: 7-8. PMID 12847147  1
2003 Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. The Journal of Biological Chemistry. 278: 31261-8. PMID 12761223 DOI: 10.1074/jbc.M304122200  1
2003 Rao MV, Nixon RA. Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review. Neurochemical Research. 28: 1041-7. PMID 12737529 DOI: 10.1023/A:1023259207015  1
2002 Rao MV, Engle LJ, Mohan PS, Yuan A, Qiu D, Cataldo A, Hassinger L, Jacobsen S, Lee VM, Andreadis A, Julien JP, Bridgman PC, Nixon RA. Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. The Journal of Cell Biology. 159: 279-90. PMID 12403814 DOI: 10.1083/jcb.200205062  1
2002 Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, et al. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proceedings of the National Academy of Sciences of the United States of America. 99: 14452-7. PMID 12388777 DOI: 10.1073/pnas.222413999  1
2002 Di Rosa G, Odrijin T, Nixon RA, Arancio O. Calpain inhibitors: a treatment for Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 19: 135-41. PMID 12212771  1
2002 Rao MV, Garcia ML, Miyazaki Y, Gotow T, Yuan A, Mattina S, Ward CM, Calcutt NA, Uchiyama Y, Nixon RA, Cleveland DW. Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. The Journal of Cell Biology. 158: 681-93. PMID 12186852 DOI: 10.1083/jcb.200202037  1
2002 Adamec E, Murrell JR, Takao M, Hobbs W, Nixon RA, Ghetti B, Vonsattel JP. P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein. Journal of the Neurological Sciences. 200: 85-93. PMID 12127682 DOI: 10.1016/S0022-510X(02)00150-8  1
2002 Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA. Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments. The Journal of Biological Chemistry. 277: 36415-24. PMID 12087104 DOI: 10.1074/jbc.M205208200  1
2002 Adamec E, Mohan P, Vonsattel JP, Nixon RA. Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. Acta Neuropathologica. 104: 92-104. PMID 12070670 DOI: 10.1007/s00401-002-0528-6  1
2002 Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, et al. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. The Journal of Biological Chemistry. 277: 28135-42. PMID 12032140 DOI: 10.1074/jbc.M110871200  1
2002 Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis. The Journal of Biological Chemistry. 277: 5299-307. PMID 11551970 DOI: 10.1074/jbc.M108161200  1
2001 Nixon RA, Mathews PM, Cataldo AM. The neuronal endosomal-lysosomal system in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 3: 97-107. PMID 12214078  1
2001 Adamec E, Yang F, Cole GM, Nixon RA. Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration. Brain Research. Brain Research Protocols. 7: 193-202. PMID 11431120 DOI: 10.1016/S1385-299X(01)00072-1  1
2000 Nixon RA. A "protease activation cascade" in the pathogenesis of Alzheimer's disease. Annals of the New York Academy of Sciences. 924: 117-31. PMID 11193788  1
2000 Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408: 979-82. PMID 11140685 DOI: 10.1038/35050110  1
2000 Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, ... ... Nixon RA, et al. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine (Cambridge, Mass.). 6: 878-91. PMID 11126202  1
2000 Adamec E, Mohan PS, Cataldo AM, Vonsattel JP, Nixon RA. Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease. Neuroscience. 100: 663-75. PMID 11098128 DOI: 10.1016/S0306-4522(00)00281-5  1
2000 Sánchez I, Hassinger L, Sihag RK, Cleveland DW, Mohan P, Nixon RA. Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation. The Journal of Cell Biology. 151: 1013-24. PMID 11086003 DOI: 10.1083/jcb.151.5.1013  1
2000 Nixon RA, Cataldo AM, Mathews PM. The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochemical Research. 25: 1161-72. PMID 11059790  1
2000 Anderson AJ, Stoltzner S, Lai F, Su J, Nixon RA. Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. Neurobiology of Aging. 21: 511-24. PMID 10924764 DOI: 10.1016/S0197-4580(00)00126-3  1
2000 Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. The American Journal of Pathology. 157: 277-86. PMID 10880397  1
1999 Adamec E, Vonsattel JP, Nixon RA. DNA strand breaks in Alzheimer's disease. Brain Research. 849: 67-77. PMID 10592288 DOI: 10.1016/S0006-8993(99)02004-1  1
1999 Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657  1
1999 Lai F, Kammann E, Rebeck GW, Anderson A, Chen Y, Nixon RA. APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology. 53: 331-6. PMID 10430422  1
1999 Buchner K, Adamec E, Beermann ML, Nixon RA. Isoform-specific translocation of protein kinase C following glutamate administration in primary hippocampal neurons. Brain Research. Molecular Brain Research. 64: 222-35. PMID 9931492 DOI: 10.1016/S0169-328X(98)00324-6  1
1999 Sihag RK, Jaffe H, Nixon RA, Rong X. Serine-23 is a major protein kinase A phosphorylation site on the amino-terminal head domain of the middle molecular mass subunit of neurofilament proteins. Journal of Neurochemistry. 72: 491-9. PMID 9930720 DOI: 10.1046/j.1471-4159.1999.0720491.x  1
1998 Nixon RA. Dynamic behavior and organization of cytoskeletal proteins in neurons: reconciling old and new findings. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 20: 798-807. PMID 9819567 DOI: 10.1002/(SICI)1521-1878(199810)20:10<798::AID-BIES5>3.0.CO;2-7  1
1998 Nixon RA. The slow axonal transport debate. Trends in Cell Biology. 8: 100. PMID 9722407  1
1998 Wang KK, Posmantur R, Nadimpalli R, Nath R, Mohan P, Nixon RA, Talanian RV, Keegan M, Herzog L, Allen H. Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis. Archives of Biochemistry and Biophysics. 356: 187-96. PMID 9705209 DOI: 10.1006/abbi.1998.0748  1
1998 Adamec E, Didier M, Nixon RA. Developmental regulation of the recovery process following glutamate-induced calcium rise in rodent primary neuronal cultures. Brain Research. Developmental Brain Research. 108: 101-10. PMID 9693788 DOI: 10.1016/S0165-3806(98)00034-0  1
1998 Troncoso JC, Cataldo AM, Nixon RA, Barnett JL, Lee MK, Checler F, Fowler DR, Smialek JE, Crain B, Martin LJ, Kawas CH. Neuropathology of preclinical and clinical late-onset Alzheimer's disease. Annals of Neurology. 43: 673-6. PMID 9585365 DOI: 10.1002/ana.410430519  1
1998 Adamec E, Beermann ML, Nixon RA. Calpain I activation in rat hippocampal neurons in culture is NMDA receptor selective and not essential for excitotoxic cell death. Brain Research. Molecular Brain Research. 54: 35-48. PMID 9526039 DOI: 10.1016/S0169-328X(97)00304-5  1
1998 Nixon RA. The slow axonal transport of cytoskeletal proteins. Current Opinion in Cell Biology. 10: 87-92. PMID 9484599 DOI: 10.1016/S0955-0674(98)80090-2  1
1998 Shiurba RA, Spooner ET, Ishiguro K, Takahashi M, Yoshida R, Wheelock TR, Imahori K, Cataldo AM, Nixon RA. Immunocytochemistry of formalin-fixed human brain tissues: microwave irradiation of free-floating sections. Brain Research. Brain Research Protocols. 2: 109-19. PMID 9473616 DOI: 10.1016/S1385-299X(97)00029-9  1
1997 Grynspan F, Griffin WR, Cataldo A, Katayama S, Nixon RA. Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. Brain Research. 763: 145-58. PMID 9296555 DOI: 10.1016/S0006-8993(97)00384-3  1
1997 Cataldo AM, Barnett JL, Pieroni C, Nixon RA. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 6142-51. PMID 9236226  1
1997 Shea TB, Dahl DC, Nixon RA, Fischer I. Triton-soluble phosphovariants of the heavy neurofilament subunit in developing and mature mouse central nervous system. Journal of Neuroscience Research. 48: 515-23. PMID 9210521 DOI: 10.1002/(SICI)1097-4547(19970615)48:6<515::AID-JNR4>3.0.CO;2-D  1
1997 Adamec E, Mercken M, Beermann ML, Didier M, Nixon RA. Acute rise in the concentration of free cytoplasmic calcium leads to dephosphorylation of the microtubule-associated protein tau. Brain Research. 757: 93-101. PMID 9200503 DOI: 10.1016/S0006-8993(97)00166-2  1
1997 Grynspan F, Griffin WB, Mohan PS, Shea TB, Nixon RA. Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system. Journal of Neuroscience Research. 48: 181-91. PMID 9160241 DOI: 10.1002/(SICI)1097-4547(19970501)48:3<181::AID-JNR1>3.0.CO;2-B  1
1996 Shiurba RA, Ishiguro K, Takahashi M, Sato K, Spooner ET, Mercken M, Yoshida R, Wheelock TR, Yanagawa H, Imahori K, Nixon RA. Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology. Brain Research. 737: 119-32. PMID 8930358 DOI: 10.1016/0006-8993(96)00717-2  1
1996 Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA. Abnormalities of the endosomal-lysosomal system in Alzheimer's disease: relationship to disease pathogenesis. Advances in Experimental Medicine and Biology. 389: 271-80. PMID 8861021  1
1996 Sánchez I, Hassinger L, Paskevich PA, Shine HD, Nixon RA. Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 5095-105. PMID 8756439  1
1996 Cataldo AM, Barnett JL, Mann DM, Nixon RA. Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome. Journal of Neuropathology and Experimental Neurology. 55: 704-15. PMID 8642396  1
1996 Shea TB, Spencer MJ, Beermann ML, Cressman CM, Nixon RA. Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C. Journal of Neurochemistry. 66: 1539-49. PMID 8627310  1
1996 Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 186-99. PMID 8613784  1
1996 Didier M, Bursztajn S, Adamec E, Passani L, Nixon RA, Coyle JT, Wei JY, Berman SA. DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2238-50. PMID 8601804  1
1995 Compaine A, Schein JD, Tabb JS, Mohan PS, Nixon RA. Limited proteolytic processing of the mature form of cathepsin D in human and mouse brain: postmortem stability of enzyme structure and activity. Neurochemistry International. 27: 385-96. PMID 8845739 DOI: 10.1016/0197-0186(95)00020-9  1
1995 Mercken M, Fischer I, Kosik KS, Nixon RA. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 8259-67. PMID 8613759  1
1995 Nixon RA, Cataldo AM. The endosomal-lysosomal system of neurons: new roles. Trends in Neurosciences. 18: 489-96. PMID 8592758 DOI: 10.1016/0166-2236(95)92772-I  1
1995 Shea TB, Beermann ML, Nixon RA. Aluminum treatment of intact neuroblastoma cells alters neurofilament subunit phosphorylation, solubility, and proteolysis. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 26: 1-14. PMID 8588820 DOI: 10.1007/BF02814937  1
1995 Mohan PS, Nixon RA. Purification and properties of high molecular weight calpastatin from bovine brain. Journal of Neurochemistry. 64: 859-66. PMID 7830080  1
1995 Schwagerl AL, Mohan PS, Cataldo AM, Vonsattel JP, Kowall NW, Nixon RA. Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease. Journal of Neurochemistry. 64: 443-6. PMID 7798944  1
1995 Cataldo AM, Barnett JL, Berman SA, Li J, Quarless S, Bursztajn S, Lippa C, Nixon RA. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron. 14: 671-80. PMID 7695914 DOI: 10.1016/0896-6273(95)90324-0  1
1995 Shea TB, Cressman CM, Spencer MJ, Beermann ML, Nixon RA. Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C. Journal of Neurochemistry. 65: 517-27. PMID 7616205  1
1995 Mercken M, Grynspan F, Nixon RA. Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau. Febs Letters. 368: 10-4. PMID 7615058 DOI: 10.1016/0014-5793(95)00590-6  1
1995 Cressman CM, Mohan PS, Nixon RA, Shea TB. Proteolysis of protein kinase C: mM and microM calcium-requiring calpains have different abilities to generate, and degrade the free catalytic subunit, protein kinase M. Febs Letters. 367: 223-7. PMID 7607311 DOI: 10.1016/0014-5793(95)00543-I  1
1994 Shea TB, Beermann ML, Honda T, Nixon RA. Secretion of amyloid precursor protein and laminin by cultured astrocytes is influenced by culture conditions. Journal of Neuroscience Research. 37: 197-207. PMID 8151728 DOI: 10.1002/jnr.490370205  1
1994 Cataldo AM, Hamilton DJ, Nixon RA. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain Research. 640: 68-80. PMID 8004466 DOI: 10.1016/0006-8993(94)91858-9  1
1994 Nixon RA, Cataldo AM. Free radicals, proteolysis, and the degeneration of neurons in Alzheimer disease: how essential is the beta-amyloid link? Neurobiology of Aging. 15: 463-9; discussion 47. PMID 7969724 DOI: 10.1016/0197-4580(94)90079-5  1
1994 Nixon RA, Saito KI, Grynspan F, Griffin WR, Katayama S, Honda T, Mohan PS, Shea TB, Beermann M. Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Annals of the New York Academy of Sciences. 747: 77-91. PMID 7847693  1
1994 Burke WJ, Galvin NJ, Chung HD, Stoff SA, Gillespie KN, Cataldo AM, Nixon RA. Degenerative changes in epinephrine tonic vasomotor neurons in Alzheimer's disease. Brain Research. 661: 35-42. PMID 7834382 DOI: 10.1016/0006-8993(94)91177-0  1
1994 Sihag RK, Wang LW, Cataldo AM, Hamlin M, Cohen CM, Nixon RA. Evidence for the association of protein 4.1 immunoreactive forms with neurofibrillary tangles in Alzheimer's disease brains. Brain Research. 656: 14-26. PMID 7804827 DOI: 10.1016/0006-8993(94)91361-7  1
1994 Nixon RA. Neuronal degenerative mechanisms as clues to pathogenesis and treatment of Alzheimer's disease. Neurobiology of Aging. 15: S61-5. PMID 7700464 DOI: 10.1016/0197-4580(94)90172-4  1
1994 Nixon RA, Lewis SE, Mercken M, Sihag RK. [32P]orthophosphate and [35S]methionine label separate pools of neurofilaments with markedly different axonal transport kinetics in mouse retinal ganglion cells in vivo. Neurochemical Research. 19: 1445-53. PMID 7534878 DOI: 10.1007/BF00972474  1
1994 Nixon RA, Paskevich PA, Sihag RK, Thayer CY. Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber. The Journal of Cell Biology. 126: 1031-46. PMID 7519617 DOI: 10.1083/jcb.126.4.1031  1
1993 Nixon RA, Cataldo AM. The lysosomal system in neuronal cell death: a review. Annals of the New York Academy of Sciences. 679: 87-109. PMID 8512210  1
1993 Saito K, Nixon RA. Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human mu CANP and mCANP. Neurochemical Research. 18: 231-3. PMID 8474564 DOI: 10.1007/BF01474689  1
1993 Saito K, Elce JS, Hamos JE, Nixon RA. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 90: 2628-32. PMID 8464868  1
1993 Leli U, Shea TB, Cataldo A, Hauser G, Grynspan F, Beermann ML, Liepkalns VA, Nixon RA, Parker PJ. Differential expression and subcellular localization of protein kinase C alpha, beta, gamma, delta, and epsilon isoforms in SH-SY5Y neuroblastoma cells: modifications during differentiation. Journal of Neurochemistry. 60: 289-98. PMID 8417148 DOI: 10.1111/j.1471-4159.1993.tb05850.x  1
1993 Nixon RA. The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathobiology. Brain Pathology (Zurich, Switzerland). 3: 29-38. PMID 7505700  1
1992 Shea TB, Beermann ML, Nixon RA. Aluminum alters the electrophoretic properties of neurofilament proteins: role of phosphorylation state. Journal of Neurochemistry. 58: 542-7. PMID 1729399  1
1992 Nixon RA, Shea TB. Dynamics of neuronal intermediate filaments: a developmental perspective. Cell Motility and the Cytoskeleton. 22: 81-91. PMID 1633625 DOI: 10.1002/cm.970220202  1
1992 Shea TB, Beermann ML, Nixon RA. Sequential effects of astroglial-derived factors on neurite outgrowth: initiation by protease inhibitors and potentiation by extracellular matrix components. Journal of Neuroscience Research. 31: 309-17. PMID 1573681 DOI: 10.1002/jnr.490310212  1
1992 Takeuchi KH, Saito KI, Nixon RA. Immunoassay and activity of calcium-activated neutral proteinase (mCANP): distribution in soluble and membrane-associated fractions in human and mouse brain. Journal of Neurochemistry. 58: 1526-32. PMID 1548485  1
1992 Leli U, Cataldo A, Shea TB, Nixon RA, Hauser G. Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors. Journal of Neurochemistry. 58: 1191-8. PMID 1548459  1
1992 Shea TB, Beermann ML, Nixon RA, Fischer I. Microtubule-associated protein tau is required for axonal neurite elaboration by neuroblastoma cells. Journal of Neuroscience Research. 32: 363-74. PMID 1433385 DOI: 10.1002/jnr.490320308  1
1992 Nixon RA. Slow axonal transport. Current Opinion in Cell Biology. 4: 8-14. PMID 1373067  1
1992 Shea TB, Beermann ML, Leli U, Nixon RA. Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C. Journal of Neuroscience Research. 33: 398-407. PMID 1335089 DOI: 10.1002/jnr.490330306  1
1992 Nixon RA, Cataldo AM, Paskevich PA, Hamilton DJ, Wheelock TR, Kanaley-Andrews L. The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis. Annals of the New York Academy of Sciences. 674: 65-88. PMID 1288372  1
1991 Shea TB, Beermann ML, Nixon RA. Multiple proteases regulate neurite outgrowth in NB2a/dl neuroblastoma cells. Journal of Neurochemistry. 56: 842-51. PMID 1993897  1
1991 Cataldo AM, Paskevich PA, Kominami E, Nixon RA. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 88: 10998-1002. PMID 1837142  1
1991 Nixon RA, Sihag RK. Neurofilament phosphorylation: a new look at regulation and function. Trends in Neurosciences. 14: 501-6. PMID 1726767  1
1991 Sihag RK, Nixon RA. Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport. The Journal of Biological Chemistry. 266: 18861-7. PMID 1717455  1
1990 Cataldo AM, Thayer CY, Bird ED, Wheelock TR, Nixon RA. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin. Brain Research. 513: 181-92. PMID 2350688 DOI: 10.1016/0006-8993(90)90456-L  1
1990 Shea TB, Beermann ML, Nixon RA. Post-translational modification of alpha-tubulin by acetylation and detyrosination in NB2a/d1 neuroblastoma cells. Brain Research. Developmental Brain Research. 51: 195-204. PMID 2323028 DOI: 10.1016/0165-3806(90)90276-5  1
1990 Shea TB, Sihag RK, Nixon RA. Dynamics of phosphorylation and assembly of the high molecular weight neurofilament subunit in NB2a/d1 neuroblastoma. Journal of Neurochemistry. 55: 1784-92. PMID 2213024  1
1990 Nixon RA, Clarke JF, Logvinenko KB, Tan MK, Hoult M, Grynspan F. Aluminum inhibits calpain-mediated proteolysis and induces human neurofilament proteins to form protease-resistant high molecular weight complexes. Journal of Neurochemistry. 55: 1950-9. PMID 2121904 DOI: 10.1111/j.1471-4159.1990.tb05781.x  1
1990 Sihag RK, Nixon RA. Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases. The Journal of Biological Chemistry. 265: 4166-71. PMID 2105960  1
1990 Canoso RT, de Oliveira RM, Nixon RA. Neuroleptic-associated autoantibodies. A prevalence study. Biological Psychiatry. 27: 863-70. PMID 1970485 DOI: 10.1016/0006-3223(90)90467-G  1
1990 Cataldo AM, Nixon RA. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proceedings of the National Academy of Sciences of the United States of America. 87: 3861-5. PMID 1692625 DOI: 10.1073/pnas.87.10.3861  1
1990 Nixon RA, Fischer I, Lewis SE. Synthesis, axonal transport, and turnover of the high molecular weight microtubule-associated protein MAP 1A in mouse retinal ganglion cells: tubulin and MAP 1A display distinct transport kinetics. The Journal of Cell Biology. 110: 437-48. PMID 1688856  1
1989 Shea TB, Clarke JF, Wheelock TR, Paskevich PA, Nixon RA. Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/dl neuroblastoma. Brain Research. 492: 53-64. PMID 2752311 DOI: 10.1016/0006-8993(89)90888-3  1
1989 Falk WE, Rosenbaum JF, Otto MW, Zusky PM, Weilburg JB, Nixon RA. Fluoxetine versus trazodone in depressed geriatric patients. Journal of Geriatric Psychiatry and Neurology. 2: 208-14. PMID 2699556 DOI: 10.1177/089198878900200407  1
1989 Nixon RA. Calcium-activated neutral proteinases as regulators of cellular function. Implications for Alzheimer's disease pathogenesis. Annals of the New York Academy of Sciences. 568: 198-208. PMID 2560900 DOI: 10.1111/j.1749-6632.1989.tb12509.x  1
1989 Shea TB, Beermann ML, Nixon RA. Appearance and localization of phosphorylated variants of the high molecular weight neurofilament protein in NB2a/d1 cytoskeletons during differentiation. Brain Research. Developmental Brain Research. 50: 142-6. PMID 2510955 DOI: 10.1016/0165-3806(89)90134-X  1
1989 Sihag RK, Nixon RA. In vivo phosphorylation of distinct domains of the 70-kilodalton neurofilament subunit involves different protein kinases. The Journal of Biological Chemistry. 264: 457-64. PMID 2491851  1
1989 Nixon RA, Lewis SE, Dahl D, Marotta CA, Drager UC. Early posttranslational modifications of the three neurofilament subunits in mouse retinal ganglion cells: neuronal sites and time course in relation to subunit polymerization and axonal transport. Brain Research. Molecular Brain Research. 5: 93-108. PMID 2469928 DOI: 10.1016/0169-328X(89)90001-6  1
1988 Sihag RK, Jeng AY, Nixon RA. Phosphorylation of neurofilament proteins by protein kinase C. Febs Letters. 233: 181-5. PMID 3384089 DOI: 10.1016/0014-5793(88)81380-2  1
1988 Pope HG, McElroy SL, Nixon RA. Possible synergism between fluoxetine and lithium in refractory depression. The American Journal of Psychiatry. 145: 1292-4. PMID 3262313  1
1988 Shea TB, Sihag RK, Nixon RA. Neurofilament triplet proteins of NB2a/d1 neuroblastoma: posttranslational modification and incorporation into the cytoskeleton during differentiation. Brain Research. 471: 97-109. PMID 3146407 DOI: 10.1016/0165-3806(88)90155-1  1
1988 Lewis SE, Nixon RA. Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: characterization and evidence for their differential association with stationary and moving neurofilaments. The Journal of Cell Biology. 107: 2689-701. PMID 3144556  1
1988 Shea TB, Majocha RE, Marotta CA, Nixon RA. Soluble, phosphorylated forms of the high molecular weight neurofilament protein in perikarya of cultured neuronal cells. Neuroscience Letters. 92: 291-7. PMID 2462197 DOI: 10.1016/0304-3940(88)90605-2  1
1988 Shea TB, Nixon RA. Differential distribution of vimentin and neurofilament protein immunoreactivity in NB2a/d1 neuroblastoma cells following neurite retraction distinguishes two separate intermediate filament systems. Brain Research. 469: 298-302. PMID 2456847 DOI: 10.1016/0165-3806(88)90191-5  1
1987 Nixon RA, Lewis SE. Phosphorylation and dephosphorylation of neurofilament proteins in retinal ganglion cell neurons in vivo. Advances in Experimental Medicine and Biology. 221: 167-86. PMID 3124528  1
1987 Nixon RA, Lewis SE, Marotta CA. Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 1145-58. PMID 2437257  1
1986 Nixon RA, Lewis SE. Differential turnover of phosphate groups on neurofilament subunits in mammalian neurons in vivo. The Journal of Biological Chemistry. 261: 16298-301. PMID 3782120  1
1986 Fleming N, Nixon RA. A versatile transition metal salt reaction for a wide range of common biochemical reagents: an instantaneous and quantifiable color test. Analytical Biochemistry. 154: 691-701. PMID 3728975 DOI: 10.1016/0003-2697(86)90048-5  1
1986 Zubenko GS, Marquis JK, Volicer L, Direnfeld LK, Langlais PJ, Nixon RA. Cerebrospinal fluid levels of angiotensin-converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: a correlative study. Biological Psychiatry. 21: 1365-81. PMID 3024746 DOI: 10.1016/0006-8993(85)91032-7  1
1986 Vitto A, Nixon RA. Calcium-activated neutral proteinase of human brain: subunit structure and enzymatic properties of multiple molecular forms. Journal of Neurochemistry. 47: 1039-51. PMID 3018155  1
1986 Nixon RA. Fodrin degradation by calcium-activated neutral proteinase (CANP) in retinal ganglion cell neurons and optic glia: preferential localization of CANP activities in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 6: 1264-71. PMID 3012012  1
1986 Nixon RA, Quackenbush R, Vitto A. Multiple calcium-activated neutral proteinases (CANP) in mouse retinal ganglion cell neurons: specificities for endogenous neuronal substrates and comparison to purified brain CANP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 6: 1252-63. PMID 3012011  1
1986 Pope HG, Hudson JI, Nixon RA, Herridge PL. The epidemiology of ipecac abuse. The New England Journal of Medicine. 314: 245-6. PMID 2867469 DOI: 10.1056/NEJM198601233140414  1
1986 Nixon RA, Logvinenko KB. Multiple fates of newly synthesized neurofilament proteins: evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons. The Journal of Cell Biology. 102: 647-59. PMID 2418034  1
1985 Zubenko GS, Nixon RA. Captopril and teprotide as discriminators of angiotensin-converting enzyme activity in brain tissue. Neuroscience Letters. 60: 33-7. PMID 2997673 DOI: 10.1016/0304-3940(85)90377-5  1
1984 Nixon RA, Marotta CA. Degradation of neurofilament proteins by purified human brain cathepsin D. Journal of Neurochemistry. 43: 507-16. PMID 6429280  1
1984 Pope A, Nixon RA. Proteases of human brain. Neurochemical Research. 9: 291-323. PMID 6377107 DOI: 10.1007/BF00963980  1
1984 Zubenko GS, Nixon RA. Mood-elevating effect of captopril in depressed patients. The American Journal of Psychiatry. 141: 110-1. PMID 6318579  1
1983 Nixon RA, Brown BA, Marotta CA. Limited proteolytic modification of a neurofilament protein involves a proteinase activated by endogenous levels of calcium. Brain Research. 275: 384-8. PMID 6414649 DOI: 10.1016/0006-8993(83)91003-X  1
1982 Nixon RA. Increased axonal proteolysis in myelin-deficient mutant mice. Science (New York, N.Y.). 215: 999-1001. PMID 7156980  1
1982 Brown BA, Nixon RA, Marotta CA. Posttranslational processing of alpha-tubulin during axoplasmic transport in CNS axons. The Journal of Cell Biology. 94: 159-64. PMID 6181079  1
1982 Nixon RA, Brown BA, Marotta CA. Posttranslational modification of a neurofilament protein during axoplasmic transport: implications for regional specialization of CNS axons. The Journal of Cell Biology. 94: 150-8. PMID 6181078  1
1981 Brown BA, Nixon RA, Strocchi P, Marotta CA. Characterization and comparison of neurofilament proteins from rat and mouse CNS. Journal of Neurochemistry. 36: 143-53. PMID 7193240 DOI: 10.1111/j.1471-4159.1981.tb02389.x  1
1981 Pope A, Amelotte JA, Belfer H, Nixon RA. Protease activities in normal and schizophrenic human prefrontal cortex and white matter. Neurochemical Research. 6: 1043-52. PMID 6174879 DOI: 10.1007/BF00964411  1
1980 Nixon RA. Protein degradation in the mouse visual system. I. Degradation of axonally transported and retinal proteins. Brain Research. 200: 69-83. PMID 6158362 DOI: 10.1016/0006-8993(80)91095-1  1
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