Ralph A. Nixon, MD - Publications

Affiliations: 
Psychiatry New York University, New York, NY, United States 
Area:
neurodegeneration, Alzheimer's disease, Autophagy

244 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lee JH, Nixon RA. Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis. Autophagy. 1-2. PMID 35947489 DOI: 10.1080/15548627.2022.2110729  0.639
2022 Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, ... ... Nixon RA, et al. Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nature Neuroscience. 25: 688-701. PMID 35654956 DOI: 10.1038/s41593-022-01084-8  0.649
2022 Lie PPY, Yoo L, Goulbourne CN, Berg MJ, Stavrides P, Huo C, Lee JH, Nixon RA. Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca efflux and disrupted by PSEN1 loss of function. Science Advances. 8: eabj5716. PMID 35486730 DOI: 10.1126/sciadv.abj5716  0.573
2021 Pensalfini A, Jiang Y, Kim S, Nixon RA. Assessing Rab5 Activation in Health and Disease. Methods in Molecular Biology (Clifton, N.J.). 2293: 273-294. PMID 34453725 DOI: 10.1007/978-1-0716-1346-7_20  0.76
2021 Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT. Alzheimer disease. Nature Reviews. Disease Primers. 7: 33. PMID 33986301 DOI: 10.1038/s41572-021-00269-y  0.337
2020 Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, ... Nixon RA, et al. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell Reports. 33: 108420. PMID 33238112 DOI: 10.1016/j.celrep.2020.108420  0.819
2020 Nixon RA. The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140443. PMID 32416272 DOI: 10.1016/J.Bbapap.2020.140443  0.36
2020 Gafson AR, Barthélemy NR, Bomont P, Carare RO, Durham HD, Julien JP, Kuhle J, Leppert D, Nixon RA, Weller RO, Zetterberg H, Matthews PM. Neurofilaments: neurobiological foundations for biomarker applications. Brain : a Journal of Neurology. PMID 32408345 DOI: 10.1093/Brain/Awaa098  0.312
2020 Lee JH, Wolfe DM, Darji S, McBrayer MK, Colacurcio DJ, Kumar A, Stavrides P, Mohan PS, Nixon RA. β2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7. Journal of Molecular Biology. PMID 32105735 DOI: 10.1016/J.Jmb.2020.02.021  0.613
2019 Bordi M, Darji S, Sato Y, Mellén M, Berg MJ, Kumar A, Jiang Y, Nixon RA. mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy. Cell Death & Disease. 10: 563. PMID 31332166 DOI: 10.1038/S41419-019-1752-5  0.311
2019 Ying J, Sato Y, Im E, Berg M, Bordi M, Darji S, Kumar A, Mohan PS, Bandyopadhyay U, Diaz A, Maria Cuervo A, Nixon RA. Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31043483 DOI: 10.1523/Jneurosci.0578-19.2019  0.502
2018 Ju-Hyun L, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA. Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. Autophagy. PMID 30269645 DOI: 10.1080/15548627.2018.1528812  0.387
2018 Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, et al. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nature Reviews. Drug Discovery. PMID 30116051 DOI: 10.1038/Nrd.2018.109  0.411
2018 Lie PPY, Nixon RA. Lysosome trafficking and signaling in health and neurodegenerative diseases. Neurobiology of Disease. PMID 29859318 DOI: 10.1016/J.Nbd.2018.05.015  0.365
2017 Colacurcio DJ, Pensalfini A, Jiang Y, Nixon RA. Dysfunction of Autophagy and Endosomal-lysosomal Pathways: Roles in Pathogenesis of Down Syndrome and Alzheimer's Disease. Free Radical Biology & Medicine. PMID 28988799 DOI: 10.1016/J.Freeradbiomed.2017.10.001  0.464
2017 Nixon RA. Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 31: 2729-2743. PMID 28663518 DOI: 10.1096/Fj.201700359  0.491
2017 Yuan A, Rao MV, Veeranna, Nixon RA. Neurofilaments and Neurofilament Proteins in Health and Disease. Cold Spring Harbor Perspectives in Biology. 9. PMID 28373358 DOI: 10.1101/Cshperspect.A018309  0.315
2017 Yang DS, Stavrides P, Kumar A, Jiang Y, Mohan PS, Ohno M, Dobrenis K, Davidson CD, Saito M, Pawlik M, Huo C, Walkley SU, Nixon RA. Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice. Human Molecular Genetics. PMID 28062666 DOI: 10.1093/Hmg/Ddx001  0.459
2016 Nixon RA. New perspectives on lysosomes in ageing and neurodegenerative disease. Ageing Research Reviews. 32: 1. PMID 27894596 DOI: 10.1016/J.Arr.2016.11.001  0.3
2016 Bordi M, Berg MJ, Mohan PS, Peterhoff CM, Alldred MJ, Che S, Ginsberg SD, Nixon RA. Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy. 1-17. PMID 27813694 DOI: 10.1080/15548627.2016.1239003  0.442
2016 Colacurcio DJ, Nixon RA. Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Research Reviews. PMID 27197071 DOI: 10.1016/J.Arr.2016.05.004  0.362
2016 Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiology of Aging. 39: 90-98. PMID 26923405 DOI: 10.1016/J.Neurobiolaging.2015.11.013  0.659
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Nixon RA, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.527
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Nixon RA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.558
2016 Rao MV, Campbell J, Palaniappan A, Kumar A, Nixon RA. Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice. Journal of Neurochemistry. PMID 26756888 DOI: 10.1111/Jnc.13536  0.37
2015 Hamlett E, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AE. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Current Alzheimer Research. PMID 26391050 DOI: 10.2174/1567205012666150921095505  0.391
2015 Lee JH, McBrayer MK, Wolfe DM, Haslett LJ, Kumar A, Sato Y, Lie PP, Mohan P, Coffey EE, Kompella U, Mitchell CH, Lloyd-Evans E, Nixon RA. Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification. Cell Reports. PMID 26299959 DOI: 10.1016/J.Celrep.2015.07.050  0.592
2015 Yuan A, Hassinger L, Rao MV, Julien JP, Miller CC, Nixon RA. Dissociation of Axonal Neurofilament Content from Its Transport Rate. Plos One. 10: e0133848. PMID 26208164 DOI: 10.1371/Journal.Pone.0133848  0.462
2015 Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA. Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease. Molecular Psychiatry. PMID 26194181 DOI: 10.1038/Mp.2015.97  0.798
2015 Yuan A, Sershen H, Veeranna, Basavarajappa BS, Kumar A, Hashim A, Berg M, Lee JH, Sato Y, Rao MV, Mohan PS, Dyakin V, Julien JP, Lee VM, Nixon RA. Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo. Molecular Psychiatry. PMID 25869803 DOI: 10.1038/Mp.2015.45  0.557
2015 Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, et al. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 700-9. PMID 25510383 DOI: 10.1016/J.Jalz.2014.10.007  0.407
2015 Xu W, Fitzgerald S, Nixon RA, Levy E, Wilson DA. Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease. Experimental Neurology. 264: 82-91. PMID 25500142 DOI: 10.1016/J.Expneurol.2014.12.008  0.426
2015 Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA, Rao MV, Lam W, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O'Kane CJ, Rubinsztein DC. Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity. Cell Death and Differentiation. 22: 433-44. PMID 25257175 DOI: 10.1038/Cdd.2014.151  0.393
2014 Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, ... ... Nixon RA, et al. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S430-52. PMID 25341459 DOI: 10.1016/J.Jalz.2014.08.103  0.356
2014 Yang DS, Stavrides P, Saito M, Kumar A, Rodriguez-Navarro JA, Pawlik M, Huo C, Walkley SU, Saito M, Cuervo AM, Nixon RA. Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits. Brain : a Journal of Neurology. 137: 3300-18. PMID 25270989 DOI: 10.1093/Brain/Awu278  0.415
2014 Xu W, Lopez-Guzman M, Schoen C, Fitzgerald S, Lauer SL, Nixon RA, Levy E, Wilson DA. Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease. Plos One. 9: e106431. PMID 25181487 DOI: 10.1371/Journal.Pone.0106431  0.305
2014 Xue X, Wang LR, Sato Y, Jiang Y, Berg M, Yang DS, Nixon RA, Liang XJ. Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease. Nano Letters. 14: 5110-7. PMID 25115676 DOI: 10.1021/Nl501839Q  0.438
2014 Rao MV, McBrayer MK, Campbell J, Kumar A, Hashim A, Sershen H, Stavrides PH, Ohno M, Hutton M, Nixon RA. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9222-34. PMID 25009256 DOI: 10.1523/Jneurosci.1132-14.2014  0.448
2014 Nixon RA. Alzheimer neurodegeneration, autophagy, and Abeta secretion: the ins and outs (comment on DOI 10.1002/bies.201400002). Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 547. PMID 24819351 DOI: 10.1002/Bies.201400064  0.425
2014 Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, et al. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. Human Molecular Genetics. 23: 3975-89. PMID 24619358 DOI: 10.1093/Hmg/Ddu112  0.364
2013 McBrayer M, Nixon RA. Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime. Biochemical Society Transactions. 41: 1495-502. PMID 24256243 DOI: 10.1042/Bst20130201  0.398
2013 Annunziata I, Patterson A, Helton D, Hu H, Moshiach S, Gomero E, Nixon R, D'Azzo A. Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis Nature Communications. 4. PMID 24225533 DOI: 10.1038/Ncomms3734  0.386
2013 Yuan A, Kumar A, Sasaki T, Duff K, Nixon RA. Global axonal transport rates are unaltered in htau mice in vivo. Journal of Alzheimer's Disease : Jad. 37: 579-86. PMID 23948900 DOI: 10.3233/Jad-130671  0.36
2013 Nixon RA. The role of autophagy in neurodegenerative disease. Nature Medicine. 19: 983-97. PMID 23921753 DOI: 10.1038/Nm.3232  0.413
2013 Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA. Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. The European Journal of Neuroscience. 37: 1949-61. PMID 23773064 DOI: 10.1111/Ejn.12169  0.639
2013 Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM. Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiology of Aging. 34: 137-45. PMID 22608241 DOI: 10.1016/J.Neurobiolaging.2012.04.007  0.638
2012 Nixon RA, Yang DS. Autophagy and neuronal cell death in neurological disorders. Cold Spring Harbor Perspectives in Biology. 4. PMID 22983160 DOI: 10.1101/Cshperspect.A008839  0.388
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Nixon RA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.54
2012 Ihara Y, Morishima-Kawashima M, Nixon R. The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2. PMID 22908190 DOI: 10.1101/cshperspect.a006361  0.36
2012 Yuan A, Sasaki T, Kumar A, Peterhoff CM, Rao MV, Liem RK, Julien JP, Nixon RA. Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8501-8. PMID 22723690 DOI: 10.1523/Jneurosci.1081-12.2012  0.359
2012 Schmidt SD, Mazzella MJ, Nixon RA, Mathews PM. Aβ measurement by enzyme-linked immunosorbent assay. Methods in Molecular Biology (Clifton, N.J.). 849: 507-27. PMID 22528112 DOI: 10.1007/978-1-61779-551-0_34  0.615
2012 Schmidt SD, Nixon RA, Mathews PM. Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ. Methods in Molecular Biology (Clifton, N.J.). 849: 493-506. PMID 22528111 DOI: 10.1007/978-1-61779-551-0_33  0.582
2012 Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA, Mathews PM. Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiology of Aging. 33: 1125.e9-18. PMID 22206846 DOI: 10.1016/J.Neurobiolaging.2011.11.023  0.625
2012 Wolfe DM, Nixon RA. Autophagy failure in Alzheimer’s disease and lysosomal storage disorders: A common pathway to neurodegeneration? Autophagy of the Nervous System: Cellular Self-Digestion in Neurons and Neurological Diseases. 237-257. DOI: 10.1142/9789814350457_0010  0.324
2012 Morales-Corraliza J, Schmidt S, Mazzella M, Berger JD, Wilson D, Wesson D, Jucker M, Levy E, Nixon R, Mathews P. Immunization targeting a minor plaque constituent clears Aβ and rescues behavioral deficits in an Alzheimer's disease mouse model Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1667  0.606
2011 Wesson DW, Borkowski AH, Landreth GE, Nixon RA, Levy E, Wilson DA. Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15962-71. PMID 22049439 DOI: 10.1523/Jneurosci.2085-11.2011  0.352
2011 Lee S, Sato Y, Nixon RA. Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy. Autophagy. 7: 1562-3. PMID 22024748 DOI: 10.4161/Auto.7.12.17956  0.355
2011 Ginsberg SD, Mufson EJ, Alldred MJ, Counts SE, Wuu J, Nixon RA, Che S. Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. Journal of Chemical Neuroanatomy. 42: 102-10. PMID 21669283 DOI: 10.1016/J.Jchemneu.2011.05.012  0.436
2011 Lee S, Sato Y, Nixon RA. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7817-30. PMID 21613495 DOI: 10.1523/Jneurosci.6412-10.2011  0.398
2011 Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Nixon RA, et al. Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy. 7: 788-9. PMID 21464620 DOI: 10.4161/Auto.7.7.15596  0.656
2011 Wesson DW, Nixon RA, Levy E, Wilson DA. Mechanisms of neural and behavioral dysfunction in Alzheimer's disease. Molecular Neurobiology. 43: 163-79. PMID 21424679 DOI: 10.1007/S12035-011-8177-1  0.402
2011 Nixon RA, Yang DS. Autophagy failure in Alzheimer's disease--locating the primary defect. Neurobiology of Disease. 43: 38-45. PMID 21296668 DOI: 10.1016/J.Nbd.2011.01.021  0.491
2011 Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Nixon RA, et al. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain : a Journal of Neurology. 134: 258-77. PMID 21186265 DOI: 10.1093/Brain/Awq341  0.668
2011 Veeranna, Yang DS, Lee JH, Vinod KY, Stavrides P, Amin ND, Pant HC, Nixon RA. Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiology of Aging. 32: 2016-29. PMID 20031277 DOI: 10.1016/J.Neurobiolaging.2009.12.001  0.597
2010 Rubinsztein DC, Nixon RA. Rapamycin induces autophagic flux in neurons. Proceedings of the National Academy of Sciences of the United States of America. 107: E181; author reply E. PMID 21115811 DOI: 10.1073/Pnas.1014633107  0.375
2010 Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14946-54. PMID 21068297 DOI: 10.1523/Jneurosci.4305-10.2010  0.465
2010 Kaur G, Mohan P, Pawlik M, DeRosa S, Fajiculay J, Che S, Grubb A, Ginsberg SD, Nixon RA, Levy E. Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy. The American Journal of Pathology. 177: 2256-67. PMID 20889561 DOI: 10.2353/Ajpath.2010.100461  0.349
2010 Ginsberg SD, Mufson EJ, Counts SE, Wuu J, Alldred MJ, Nixon RA, Che S. Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 22: 631-9. PMID 20847427 DOI: 10.3233/Jad-2010-101080  0.43
2010 Ginsberg SD, Alldred MJ, Counts SE, Cataldo AM, Neve RL, Jiang Y, Wuu J, Chao MV, Mufson EJ, Nixon RA, Che S. Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biological Psychiatry. 68: 885-93. PMID 20655510 DOI: 10.1016/J.Biopsych.2010.05.030  0.445
2010 Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell. 141: 1146-58. PMID 20541250 DOI: 10.1016/J.Cell.2010.05.008  0.668
2010 Rothenberg C, Srinivasan D, Mah L, Kaushik S, Peterhoff CM, Ugolino J, Fang S, Cuervo AM, Nixon RA, Monteiro MJ. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Human Molecular Genetics. 19: 3219-32. PMID 20529957 DOI: 10.1093/Hmg/Ddq231  0.379
2010 Wesson DW, Wilson DA, Nixon RA. Should olfactory dysfunction be used as a biomarker of Alzheimer's disease? Expert Review of Neurotherapeutics. 10: 633-5. PMID 20420483 DOI: 10.1586/Ern.10.33  0.376
2010 Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim TW. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2783-94. PMID 20354142 DOI: 10.1096/Fj.09-146357  0.453
2010 Tizon B, Sahoo S, Yu H, Gauthier S, Kumar AR, Mohan P, Figliola M, Pawlik M, Grubb A, Uchiyama Y, Bandyopadhyay U, Cuervo AM, Nixon RA, Levy E. Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. Plos One. 5: e9819. PMID 20352108 DOI: 10.1371/Journal.Pone.0009819  0.399
2010 Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proceedings of the National Academy of Sciences of the United States of America. 107: 1630-5. PMID 20080541 DOI: 10.1073/Pnas.0908953107  0.655
2010 Wesson DW, Levy E, Nixon RA, Wilson DA. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 505-14. PMID 20071513 DOI: 10.1523/Jneurosci.4622-09.2010  0.418
2010 Lee S, Nixon RA. P1-106: Dynamic modeling of autophagy defects and their pathologic consequences in Alzheimer's disease and related diseases: Contribution of proteolysis impairment and axonal transport Alzheimer's & Dementia. 6: S205-S205. DOI: 10.1016/J.Jalz.2010.05.655  0.397
2010 Lee J, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Sisodia SS, Cuervo AM, Nixon RA. P2-271: Presenilin 1 (PS1) is required for lysosome acidification: FAD mutations of PS1 cause loss of protein turnover by autophagy Alzheimer's & Dementia. 6: S393-S394. DOI: 10.1016/J.Jalz.2010.05.1321  0.566
2009 Choi JH, Berger JD, Mazzella MJ, Morales-Corraliza J, Cataldo AM, Nixon RA, Ginsberg SD, Levy E, Mathews PM. Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. Journal of Neurochemistry. 110: 1818-27. PMID 19619138 DOI: 10.1111/J.1471-4159.2009.06277.X  0.61
2009 Mi W, Jung SS, Yu H, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E. Complexes of amyloid-beta and cystatin C in the human central nervous system. Journal of Alzheimer's Disease : Jad. 18: 273-80. PMID 19584436 DOI: 10.3233/Jad-2009-1147  0.644
2009 Basavarajappa BS, Nixon RA, Arancio O. Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini Reviews in Medicinal Chemistry. 9: 448-62. PMID 19356123 DOI: 10.2174/138955709787847921  0.331
2009 Yang DS, Lee JH, Nixon RA. Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases. Methods in Enzymology. 453: 111-44. PMID 19216904 DOI: 10.1016/S0076-6879(08)04006-8  0.619
2009 Wilson DA, Nixon RA. Sniffing out a function for prion proteins. Nature Neuroscience. 12: 7-8. PMID 19107142 DOI: 10.1038/Nn0109-7  0.304
2009 Chen Y, Dyakin VV, Branch CA, Ardekani B, Yang D, Guilfoyle DN, Peterson J, Peterhoff C, Ginsberg SD, Cataldo AM, Nixon RA. In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiology of Aging. 30: 1453-65. PMID 18180075 DOI: 10.1016/J.Neurobiolaging.2007.11.026  0.355
2008 Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12798-807. PMID 19036972 DOI: 10.1523/Jneurosci.4101-08.2008  0.366
2008 Rao MV, Mohan PS, Peterhoff CM, Yang DS, Schmidt SD, Stavrides PH, Campbell J, Chen Y, Jiang Y, Paskevich PA, Cataldo AM, Haroutunian V, Nixon RA. Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12241-54. PMID 19020018 DOI: 10.1523/Jneurosci.4119-08.2008  0.487
2008 Veeranna, Lee JH, Pareek TK, Jaffee H, Boland B, Vinod KY, Amin N, Kulkarni AB, Pant HC, Nixon RA. Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. Journal of Neurochemistry. 107: 35-49. PMID 18715269 DOI: 10.1111/J.1471-4159.2008.05547.X  0.568
2008 Yang DS, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M, Levy E, Cataldo AM, Nixon RA. Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. The American Journal of Pathology. 173: 665-81. PMID 18688038 DOI: 10.2353/Ajpath.2008.071176  0.428
2008 Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 118: 2796-807. PMID 18596919 DOI: 10.1172/Jci34254  0.597
2008 Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6926-37. PMID 18596167 DOI: 10.1523/Jneurosci.0800-08.2008  0.498
2008 Cataldo AM, Mathews PM, Boiteau AB, Hassinger LC, Peterhoff CM, Jiang Y, Mullaney K, Neve RL, Gruenberg J, Nixon RA. Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. The American Journal of Pathology. 173: 370-84. PMID 18535180 DOI: 10.2353/Ajpath.2008.071053  0.648
2008 Azmitia EC, Nixon R. Dystrophic serotonergic axons in neurodegenerative diseases. Brain Research. 1217: 185-94. PMID 18502405 DOI: 10.1016/J.Brainres.2008.03.060  0.354
2008 Nixon RA, Yang DS, Lee JH. Neurodegenerative lysosomal disorders: a continuum from development to late age. Autophagy. 4: 590-9. PMID 18497567 DOI: 10.4161/Auto.6259  0.634
2008 Yuan A, Kumar A, Peterhoff C, Duff K, Nixon RA. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1682-7. PMID 18272688 DOI: 10.1523/Jneurosci.5242-07.2008  0.342
2008 Morales-Corraliza J, Berger JD, Mazzella MJ, Staufenbiel M, Rao MV, Nixon RA, Mathews PM. P1-079: Calpain inhibition by calpastatin overexpression reduces β-amyloid deposition in an APP transgenic mouse Alzheimer's & Dementia. 4: T229-T229. DOI: 10.1016/J.Jalz.2008.05.665  0.58
2008 Yang D, Stavrides P, Mohan P, Kumar A, Schmidt SD, Pawlik M, Bandyopadhyay U, Mathews PM, Levy E, Cuervo AM, Nixon RA. P1-059: Cystatin B deletion in a mouse model of Alzheimer's disease, TgCRND8, ameliorates both autophagic-lysosomal and amyloid pathologies Alzheimer's & Dementia. 4: T223-T223. DOI: 10.1016/J.Jalz.2008.05.645  0.628
2008 Choi JH, Diaz NS, Mazzella MJ, Ginsberg SD, Levy E, Nixon RA, Mathews PM. P1-011: Dysregulation of amyloid precursor protein levels, but not Aβ levels in Ts65Dn mouse brain Alzheimer's & Dementia. 4: T208-T209. DOI: 10.1016/J.Jalz.2008.05.596  0.604
2008 Kim S, Sasaki T, Nixon RA. P3-410: Alzheimer's disease-related endosome dysfunction induced by APP overexpression in neurons requires Rab5 overactivation Alzheimer's & Dementia. 4: T642-T642. DOI: 10.1016/J.Jalz.2008.05.1981  0.778
2007 Nixon RA. Autophagy, amyloidogenesis and Alzheimer disease. Journal of Cell Science. 120: 4081-91. PMID 18032783 DOI: 10.1242/Jcs.019265  0.488
2007 Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nature Genetics. 39: 1440-2. PMID 18026100 DOI: 10.1038/Ng.2007.29  0.611
2007 Battaglia F, Wang HY, Ghilardi MF, Gashi E, Quartarone A, Friedman E, Nixon RA. Cortical plasticity in Alzheimer's disease in humans and rodents. Biological Psychiatry. 62: 1405-12. PMID 17651702 DOI: 10.1016/J.Biopsych.2007.02.027  0.423
2007 Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. Journal of Neurochemistry. 102: 619-26. PMID 17630980 DOI: 10.1111/J.1471-4159.2007.04587.X  0.648
2007 Falangola MF, Dyakin VV, Lee SP, Bogart A, Babb JS, Duff K, Nixon R, Helpern JA. Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease. Nmr in Biomedicine. 20: 343-51. PMID 17451178 DOI: 10.1002/Nbm.1163  0.455
2007 Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao F, Mathews PM, Xu H, Ehrlich ME. Erratum: Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (Journal of Neurochemistry (2007) 102, (619-626)) Journal of Neurochemistry. 103. DOI: 10.1111/J.1471-4159.2007.04950.X  0.611
2007 Cataldo AM, Nixon RA. Neuronal Protein Trafficking in Alzheimer's Disease and Niemann-Pick Type C Disease Protein Trafficking in Neurons. 391-411. DOI: 10.1016/B978-012369437-9/50025-6  0.303
2006 Boland B, Nixon RA. Neuronal macroautophagy: from development to degeneration. Molecular Aspects of Medicine. 27: 503-19. PMID 16999991 DOI: 10.1016/J.Mam.2006.08.009  0.421
2006 Liang J, Yin C, Doong H, Fang S, Peterhoff C, Nixon RA, Monteiro MJ. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. Journal of Cell Science. 119: 4011-24. PMID 16968747 DOI: 10.1242/Jcs.03163  0.417
2006 Nixon RA, Cataldo AM. Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 9: 277-89. PMID 16914867 DOI: 10.3233/Jad-2006-9S331  0.501
2006 Butler D, Nixon RA, Bahr BA. Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases. Autophagy. 2: 234-7. PMID 16874061 DOI: 10.4161/Auto.2729  0.381
2006 Nixon RA. Autophagy in neurodegenerative disease: friend, foe or turncoat? Trends in Neurosciences. 29: 528-35. PMID 16859759 DOI: 10.1016/J.Tins.2006.07.003  0.344
2006 Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 51: 29-42. PMID 16815330 DOI: 10.1016/J.Neuron.2006.05.022  0.422
2006 Nixon RA. A “Protease Activation Cascade” in the Pathogenesis of Alzheimer's Disease Annals of the New York Academy of Sciences. 924: 117-131. DOI: 10.1111/J.1749-6632.2000.Tb05570.X  0.462
2006 Jiang Y, Mullaney KA, Che S, Schmidt SD, Mathews PM, Cataldo AM, Ginsberg SD, Nixon RA. P2-061: APP expression modulates AD-related endosomal trafficking abnormalities in Down syndrome fibroblasts Alzheimer's & Dementia. 2: S250-S250. DOI: 10.1016/J.Jalz.2006.05.898  0.579
2006 Cataldo AM, Boyer-Boiteau A, Hassinger LC, Peterhoff CM, Jiang Y, Mathews PM, Neve RL, Nixon RA. P2-028 Alzheimer's & Dementia. 2: S240. DOI: 10.1016/J.Jalz.2006.05.865  0.47
2006 Choi JH, Diaz NS, Mazzella MJ, Peterson JN, Cataldo AM, Ginsberg SD, Levy E, Nixon RA, Mathews PM. P2-014: Dysregulation of brain APP in the Ts65Dn Down syndrome mouse Alzheimer's & Dementia. 2: S236-S236. DOI: 10.1016/J.Jalz.2006.05.851  0.536
2006 Gandy S, Zhang Y, Ikin A, Schmidt S, Sheffield R, Nixon R, Liao F, Matthews P, Xu H, Ehrlich M. S4-03-01: Evidence that aberrant post-TGN trafficking of Alzheimer's APP is sufficient to elevate brain A-beta 42 and may underlie mutant presenilin action Alzheimer's & Dementia. 2: S71-S71. DOI: 10.1016/J.Jalz.2006.05.277  0.399
2006 Yu WH, Lee J, Massey A, Peterhoff C, Kumar A, Mohan P, Cuervo AM, Nixon RA. O3-03-07: Presenilin-1 is required for macroautophagy: PS1 mutations causing AD confer loss of macroautophagy function Alzheimer's & Dementia. 2: S58-S58. DOI: 10.1016/J.Jalz.2006.05.211  0.579
2006 Lee S, Yang D, Kumar A, Levy E, Hassinger L, Cataldo AM, Nixon RA. P4-098: In vivo turnover of retrogradely transported proteins by autophagy is impaired in PS/APP transgenic mice Alzheimer's & Dementia. 2: S543-S543. DOI: 10.1016/J.Jalz.2006.05.1836  0.345
2005 Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, Stefanis L, Tolkovsky A. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy. 1: 11-22. PMID 16874045 DOI: 10.4161/Auto.1.1.1513  0.404
2005 Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, ... ... Nixon RA, et al. Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. The Journal of Cell Biology. 171: 87-98. PMID 16203860 DOI: 10.1083/Jcb.200505082  0.749
2005 de Grey AD, Alvarez PJ, Brady RO, Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR. Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Research Reviews. 4: 315-38. PMID 16040282 DOI: 10.1016/J.Arr.2005.03.008  0.301
2005 Schmidt SD, Nixon RA, Mathews PM. ELISA method for measurement of amyloid-beta levels. Methods in Molecular Biology (Clifton, N.J.). 299: 279-97. PMID 15980612 DOI: 10.1385/1-59259-874-9:279  0.626
2005 Schmidt SD, Jiang Y, Nixon RA, Mathews PM. Tissue processing prior to protein analysis and amyloid-beta quantitation. Methods in Molecular Biology (Clifton, N.J.). 299: 267-78. PMID 15980611 DOI: 10.1385/1-59259-874-9:267  0.584
2005 Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, et al. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proceedings of the National Academy of Sciences of the United States of America. 102: 8972-7. PMID 15951428 DOI: 10.1073/Pnas.0500940102  0.608
2005 Falangola MF, Lee SP, Nixon RA, Duff K, Helpern JA. Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochemical Research. 30: 201-5. PMID 15895823 DOI: 10.1007/S11064-004-2442-X  0.416
2005 Falangola MF, Ardekani BA, Lee SP, Babb JS, Bogart A, Dyakin VV, Nixon R, Duff K, Helpern JA. Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology. Journal of Neuroscience Methods. 144: 91-7. PMID 15848243 DOI: 10.1016/J.Jneumeth.2004.10.012  0.349
2005 Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. Journal of Neuropathology and Experimental Neurology. 64: 113-22. PMID 15751225 DOI: 10.1093/Jnen/64.2.113  0.491
2005 Nixon RA. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiology of Aging. 26: 373-82. PMID 15639316 DOI: 10.1016/J.Neurobiolaging.2004.09.018  0.468
2004 Carter TL, Verdile G, Groth D, Bogush A, Thomas S, Shen P, Fraser PE, Mathews P, Nixon RA, Ehrlich ME, Kwok JB, St George-Hyslop P, Schofield P, Li Y, Yang A, et al. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Disease and Associated Disorders. 18: 261-3. PMID 15592142  0.564
2004 Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, Mercken M, Mehta PD, Buxbaum J, Haroutunian V, Nixon RA. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiology of Aging. 25: 1263-72. PMID 15465622 DOI: 10.1016/J.Neurobiolaging.2004.02.027  0.481
2004 Lee SP, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 52: 538-44. PMID 15334572 DOI: 10.1002/Mrm.20196  0.446
2004 Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa BS, Peterhoff C, Cataldo A, Rudnicki A, Amin N, Li BS, Pant HC, Hungund BL, Arancio O, Nixon RA. Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. The American Journal of Pathology. 165: 795-805. PMID 15331404 DOI: 10.1016/S0002-9440(10)63342-1  0.423
2004 Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. Journal of Neuropathology and Experimental Neurology. 63: 821-30. PMID 15330337 DOI: 10.1093/Jnen/63.8.821  0.66
2004 Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. The International Journal of Biochemistry & Cell Biology. 36: 2531-40. PMID 15325590 DOI: 10.1016/J.Biocel.2004.05.010  0.442
2004 Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, et al. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of Neurochemistry. 90: 1011-8. PMID 15287908 DOI: 10.1111/J.1471-4159.2004.02532.X  0.607
2004 Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V, Schmidt SD, Nixon RA, Frangione B, Levy E. Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiology of Aging. 25: 1033-43. PMID 15212828 DOI: 10.1016/J.Neurobiolaging.2003.11.006  0.602
2004 Sadowski M, Pankiewicz J, Scholtzova H, Ji Y, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, Wisniewski T. Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. Journal of Neuropathology and Experimental Neurology. 63: 418-28. PMID 15198121 DOI: 10.1093/Jnen/63.5.418  0.402
2004 Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B, Duff K, Branch C, Wisniewski T, de Leon MJ, Wolf O, O'Shea J, Nixon RA. MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 51: 794-8. PMID 15065253 DOI: 10.1002/Mrm.20038  0.46
2004 Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. Journal of Neurochemistry. 89: 44-53. PMID 15030388 DOI: 10.1046/J.1471-4159.2003.02298.X  0.575
2004 Nixon RA. Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up. The American Journal of Pathology. 164: 757-61. PMID 14982829 DOI: 10.1016/S0002-9440(10)63163-X  0.501
2004 Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD, Nixon RA, Levy E. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide. Journal of Molecular Neuroscience : Mn. 22: 13-8. PMID 14742906 DOI: 10.1385/Jmn:22:1-2:13  0.62
2004 Zheng P, Jiang Y, Mohan PS, Mathews PM, Nixon RA. P3-292 AD-related cathepsin D overexpression promotes mitochondrial-dependent apoptosis Neurobiology of Aging. 25: S438. DOI: 10.1016/S0197-4580(04)81442-8  0.551
2004 Yang D, Kumar A, Peterson J, Peterhoff CM, Duff K, Nixon RA, Jeyathevan R, Martins RN, Cataldo AM. P3-289 Neurodegeneration in a mouse model of Alzheimer's disease (AD): roles of apoptosis and autophagy Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81439-8  0.448
2004 Pawlik M, Sastre M, Calero M, Mathews PM, Kumar A, Schmidt SD, Nixon RA, Levy E. P2-061 Binding of cystatin C to amyloid beta inhibits amyloid fibril formation Neurobiology of Aging. 25: S241. DOI: 10.1016/S0197-4580(04)80808-X  0.569
2004 Scholtzova H, Pankiewicz J, Sadowski M, Quartermain D, Jensen CH, Duff K, Nixon RA, Helpern JH, Gruen RJ, Wisniewski T. P2-007 Age-associated behavioral, metabolic, and structural changes in wild-type littermates of Alzheimer's transgenic mice Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80755-3  0.326
2004 Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa BS, Peterhoff C, Cataldo AM, Rudnicki A, Li BS, Pant HC, Hungund BL, Arancio O, Nixon RA. P1-272 Calpain mediates calcium-induced activation of the ERK 1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80585-2  0.396
2004 Cataldo AM, Mathews PM, Grbovic OM, Peterhoff CM, Jiang Y, Nixon RA. S5-02-03 Endosomal pathology in early stage Alzheimer's disease Neurobiology of Aging. 25: S90. DOI: 10.1016/S0197-4580(04)80305-1  0.58
2004 Nixon RA, Yu WH, Cuervo AM, Cataldo AM, Mathews PM, Yang D, Zheng P, Peterhoff CM, Kumar A, Jiang Y, Peterson J, Schmidt SD, Mohan P, Duff K, Hassinger L, et al. S4-03-04 Autophagy in Alzheimer's disease pathogenesis Neurobiology of Aging. 25: S70-S71. DOI: 10.1016/S0197-4580(04)80240-9  0.591
2003 Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, et al. In vivo reduction of amyloid-beta by a mutant copper transporter. Proceedings of the National Academy of Sciences of the United States of America. 100: 14193-8. PMID 14617772 DOI: 10.1073/Pnas.2332851100  0.602
2003 Nixon RA. The calpains in aging and aging-related diseases. Ageing Research Reviews. 2: 407-18. PMID 14522243 DOI: 10.1016/S1568-1637(03)00029-1  0.416
2003 Battaglia F, Trinchese F, Liu S, Walter S, Nixon RA, Arancio O. Calpain inhibitors, a treatment for Alzheimer's disease: position paper. Journal of Molecular Neuroscience : Mn. 20: 357-62. PMID 14501020 DOI: 10.1385/Jmn:20:3:357  0.442
2003 Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, Nixon RA. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6788-92. PMID 12890772 DOI: 10.1523/Jneurosci.23-17-06788.2003  0.465
2003 Tatton W, Chen D, Chalmers-Redman R, Wheeler L, Nixon R, Tatton N. Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation. Survey of Ophthalmology. S25-37. PMID 12852432 DOI: 10.1016/S0039-6257(03)00005-5  0.459
2003 Mathews PM, Nixon RA. Setback for an Alzheimer's disease vaccine: lessons learned. Neurology. 61: 7-8. PMID 12847147 DOI: 10.1212/Wnl.61.1.7  0.618
2003 Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, et al. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. 38: 555-65. PMID 12765608 DOI: 10.1016/S0896-6273(03)00259-9  0.41
2003 Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. The Journal of Biological Chemistry. 278: 31261-8. PMID 12761223 DOI: 10.1074/Jbc.M304122200  0.666
2003 Rao MV, Nixon RA. Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review. Neurochemical Research. 28: 1041-7. PMID 12737529 DOI: 10.1023/A:1023259207015  0.378
2003 Hasegawa H, Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti M, Horne P, Helsin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, et al. Aβ vaccination of a genetic model of Alzheimer's disease International Congress Series. 1252: 405-409. DOI: 10.1016/S0531-5131(03)00046-3  0.521
2002 Rao MV, Engle LJ, Mohan PS, Yuan A, Qiu D, Cataldo A, Hassinger L, Jacobsen S, Lee VM, Andreadis A, Julien JP, Bridgman PC, Nixon RA. Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. The Journal of Cell Biology. 159: 279-90. PMID 12403814 DOI: 10.1083/Jcb.200205062  0.306
2002 Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, et al. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proceedings of the National Academy of Sciences of the United States of America. 99: 14452-7. PMID 12388777 DOI: 10.1073/Pnas.222413999  0.556
2002 Di Rosa G, Odrijin T, Nixon RA, Arancio O. Calpain inhibitors: a treatment for Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 19: 135-41. PMID 12212771 DOI: 10.1007/s12031-002-0024-4  0.32
2002 Adamec E, Murrell JR, Takao M, Hobbs W, Nixon RA, Ghetti B, Vonsattel JP. P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein. Journal of the Neurological Sciences. 200: 85-93. PMID 12127682 DOI: 10.1016/S0022-510X(02)00150-8  0.402
2002 Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA. Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments. The Journal of Biological Chemistry. 277: 36415-24. PMID 12087104 DOI: 10.1074/jbc.M205208200  0.538
2002 Adamec E, Mohan P, Vonsattel JP, Nixon RA. Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. Acta Neuropathologica. 104: 92-104. PMID 12070670 DOI: 10.1007/S00401-002-0528-6  0.45
2002 Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, et al. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. The Journal of Biological Chemistry. 277: 28135-42. PMID 12032140 DOI: 10.1074/Jbc.M110871200  0.597
2002 Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis. The Journal of Biological Chemistry. 277: 5299-307. PMID 11551970 DOI: 10.1074/Jbc.M108161200  0.562
2001 Nixon RA, Mathews PM, Cataldo AM. The neuronal endosomal-lysosomal system in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 3: 97-107. PMID 12214078 DOI: 10.3233/Jad-2001-3114  0.643
2001 Cataldo A, Rebeck GW, Ghetri B, Hulette C, Lippa C, Van Broeckhoven C, van Duijn C, Cras P, Bogdanovic N, Bird T, Peterhoff C, Nixon R. Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders. Annals of Neurology. 50: 661-5. PMID 11706973 DOI: 10.1002/Ana.1254  0.499
2001 Adamec E, Yang F, Cole GM, Nixon RA. Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration. Brain Research. Brain Research Protocols. 7: 193-202. PMID 11431120 DOI: 10.1016/S1385-299X(01)00072-1  0.347
2000 Nixon RA. A "protease activation cascade" in the pathogenesis of Alzheimer's disease. Annals of the New York Academy of Sciences. 924: 117-31. PMID 11193788  0.357
2000 Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408: 979-82. PMID 11140685 DOI: 10.1038/35050110  0.598
2000 Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, ... ... Nixon RA, et al. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine (Cambridge, Mass.). 6: 878-91. PMID 11126202 DOI: 10.1007/Bf03401825  0.596
2000 Adamec E, Mohan PS, Cataldo AM, Vonsattel JP, Nixon RA. Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease. Neuroscience. 100: 663-75. PMID 11098128 DOI: 10.1016/S0306-4522(00)00281-5  0.402
2000 Nixon RA, Cataldo AM, Mathews PM. The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochemical Research. 25: 1161-72. PMID 11059790 DOI: 10.1023/A:1007675508413  0.65
2000 Anderson AJ, Stoltzner S, Lai F, Su J, Nixon RA. Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. Neurobiology of Aging. 21: 511-24. PMID 10924764 DOI: 10.1016/S0197-4580(00)00126-3  0.404
2000 Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. The American Journal of Pathology. 157: 277-86. PMID 10880397 DOI: 10.1016/S0002-9440(10)64538-5  0.507
2000 Mathews PM, Jiang Y, Guerra CB, Schmidt SD, Peterhoff CM, Cataldo AM, Nixon RA. Accelerated Aβ generation in AD models of lysosomal system upregulation Neurobiology of Aging. 21: 206. DOI: 10.1016/S0197-4580(00)83256-X  0.601
2000 Bussiere T, Wicinski BA, Lin GI, Perl DP, Davies P, Nixon RA, Morrison JH, Hof PR. Stereologic analysis of vulnerable neocortical neurons in normal aging and Alzheimer's disease Neurobiology of Aging. 21: 24-25. DOI: 10.1016/S0197-4580(00)82787-6  0.408
2000 Nixon RA, Cataldo AM, Mathews PM, Duff K, Guerra CB, Mohan P, Jiang Y, Peterhoff C. Endosomal-lysosomal mechanisms in amyloido-genesis and neurodegeneration: Animal models Neurobiology of Aging. 21: 72. DOI: 10.1016/S0197-4580(00)82543-9  0.503
2000 Cataldo AM, Nixon RA, Troncoso JC, Durham RA, Buxbaum JD, Epstein C, Carlson E, Peterhoff CM. Endocytic alterations in human preclinical AD and a trisomic mouse model of down syndrome: Implications for β-amyloidogenesis Neurobiology of Aging. 21: 65. DOI: 10.1016/S0197-4580(00)82515-4  0.342
2000 Nixon R, Duff K, Matsuoka Y. 26. The pathobiology of tau protein in neurodegenerative diseases Biological Psychiatry. 47: S7. DOI: 10.1016/S0006-3223(00)00292-4  0.392
1999 Adamec E, Vonsattel JP, Nixon RA. DNA strand breaks in Alzheimer's disease. Brain Research. 849: 67-77. PMID 10592288 DOI: 10.1016/S0006-8993(99)02004-1  0.318
1999 Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657 DOI: 10.1007/Bf03401981  0.603
1999 Lai F, Kammann E, Rebeck GW, Anderson A, Chen Y, Nixon RA. APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology. 53: 331-6. PMID 10430422 DOI: 10.1212/Wnl.53.2.331  0.374
1999 Buchner K, Adamec E, Beermann ML, Nixon RA. Isoform-specific translocation of protein kinase C following glutamate administration in primary hippocampal neurons. Brain Research. Molecular Brain Research. 64: 222-35. PMID 9931492 DOI: 10.1016/S0169-328X(98)00324-6  0.321
1998 Nixon RA. Dynamic behavior and organization of cytoskeletal proteins in neurons: reconciling old and new findings. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 20: 798-807. PMID 9819567 DOI: 10.1002/(Sici)1521-1878(199810)20:10<798::Aid-Bies5>3.0.Co;2-7  0.314
1998 Troncoso JC, Cataldo AM, Nixon RA, Barnett JL, Lee MK, Checler F, Fowler DR, Smialek JE, Crain B, Martin LJ, Kawas CH. Neuropathology of preclinical and clinical late-onset Alzheimer's disease. Annals of Neurology. 43: 673-6. PMID 9585365 DOI: 10.1002/Ana.410430519  0.344
1998 Li J, Nixon R, Messer A, Berman S, Bursztajn S. Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord Molecular Brain Research. 53: 174-186. PMID 9473662 DOI: 10.1016/S0169-328X(97)00295-7  0.306
1998 Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. The Journal of Biological Chemistry. 273: 3205-11. PMID 9452432 DOI: 10.1074/Jbc.273.6.3205  0.336
1997 Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grünberg J, Mathews P, Nixon R, Dotti C, Haass C. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. Journal of Neurochemistry. 69: 2432-40. PMID 9375676 DOI: 10.1046/J.1471-4159.1997.69062432.X  0.596
1997 Grynspan F, Griffin WR, Cataldo A, Katayama S, Nixon RA. Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. Brain Research. 763: 145-58. PMID 9296555 DOI: 10.1016/S0006-8993(97)00384-3  0.452
1997 Cataldo AM, Barnett JL, Pieroni C, Nixon RA. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 6142-51. PMID 9236226 DOI: 10.1523/Jneurosci.17-16-06142.1997  0.519
1997 Shea TB, Dahl DC, Nixon RA, Fischer I. Triton-soluble phosphovariants of the heavy neurofilament subunit in developing and mature mouse central nervous system. Journal of Neuroscience Research. 48: 515-23. PMID 9210521 DOI: 10.1002/(Sici)1097-4547(19970615)48:6<515::Aid-Jnr4>3.0.Co;2-D  0.308
1997 Adamec E, Mercken M, Beermann ML, Didier M, Nixon RA. Acute rise in the concentration of free cytoplasmic calcium leads to dephosphorylation of the microtubule-associated protein tau. Brain Research. 757: 93-101. PMID 9200503 DOI: 10.1016/S0006-8993(97)00166-2  0.316
1997 Grynspan F, Griffin WB, Mohan PS, Shea TB, Nixon RA. Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system. Journal of Neuroscience Research. 48: 181-91. PMID 9160241 DOI: 10.1002/(Sici)1097-4547(19970501)48:3<181::Aid-Jnr1>3.0.Co;2-B  0.342
1996 Li J, Grynspan F, Berman S, Nixon R, Bursztajn S. Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord. Journal of Neurobiology. 30: 177-91. PMID 8738748 DOI: 10.1002/(Sici)1097-4695(199606)30:2<177::Aid-Neu1>3.0.Co;2-2  0.303
1996 Cataldo AM, Barnett JL, Mann DM, Nixon RA. Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome. Journal of Neuropathology and Experimental Neurology. 55: 704-15. PMID 8642396 DOI: 10.1097/00005072-199606000-00004  0.45
1996 Shea TB, Spencer MJ, Beermann ML, Cressman CM, Nixon RA. Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C. Journal of Neurochemistry. 66: 1539-49. PMID 8627310 DOI: 10.1046/J.1471-4159.1996.66041539.X  0.325
1996 Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 186-99. PMID 8613784 DOI: 10.1523/Jneurosci.16-01-00186.1996  0.447
1996 Nixon R, Grynspan F, Cataldo A, Hong O, Katayama S, Mohan P, Adamec E. 573 Calpain activation, neurofibrillary pathology, and cell death in Alzheimer's disease Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80575-6  0.414
1996 Nixon R. 554 Frontiers of neuronal cell biology in Alzheimer disease pathogenesis Neurobiology of Aging. 17: S138. DOI: 10.1016/S0197-4580(96)80556-2  0.304
1996 Cataldo A, Barnett J, Nixon R. 541 Alterations in endocytosis and the localization of lysosomal hydrolases in early endosomes of neurons in Alzheimer's disease Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80543-4  0.434
1995 Mercken M, Fischer I, Kosik KS, Nixon RA. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 8259-67. PMID 8613759 DOI: 10.1523/Jneurosci.15-12-08259.1995  0.339
1995 Nixon RA, Cataldo AM. The endosomal-lysosomal system of neurons: new roles. Trends in Neurosciences. 18: 489-96. PMID 8592758 DOI: 10.1016/0166-2236(95)92772-I  0.379
1995 Shea TB, Beermann ML, Nixon RA. Aluminum treatment of intact neuroblastoma cells alters neurofilament subunit phosphorylation, solubility, and proteolysis. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 26: 1-14. PMID 8588820 DOI: 10.1007/Bf02814937  0.321
1995 Schwagerl AL, Mohan PS, Cataldo AM, Vonsattel JP, Kowall NW, Nixon RA. Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease. Journal of Neurochemistry. 64: 443-6. PMID 7798944 DOI: 10.1046/J.1471-4159.1995.64010443.X  0.41
1995 Cataldo AM, Barnett JL, Berman SA, Li J, Quarless S, Bursztajn S, Lippa C, Nixon RA. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron. 14: 671-80. PMID 7695914 DOI: 10.1016/0896-6273(95)90324-0  0.373
1995 Shea TB, Cressman CM, Spencer MJ, Beermann ML, Nixon RA. Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C. Journal of Neurochemistry. 65: 517-27. PMID 7616205 DOI: 10.1046/J.1471-4159.1995.65020517.X  0.337
1995 Mercken M, Grynspan F, Nixon RA. Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau. Febs Letters. 368: 10-4. PMID 7615058 DOI: 10.1016/0014-5793(95)00590-6  0.406
1994 Shea TB, Beermann ML, Honda T, Nixon RA. Secretion of amyloid precursor protein and laminin by cultured astrocytes is influenced by culture conditions. Journal of Neuroscience Research. 37: 197-207. PMID 8151728 DOI: 10.1002/Jnr.490370205  0.324
1994 Cataldo AM, Hamilton DJ, Nixon RA. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain Research. 640: 68-80. PMID 8004466 DOI: 10.1016/0006-8993(94)91858-9  0.475
1994 Nixon RA, Cataldo AM. Free radicals, proteolysis, and the degeneration of neurons in Alzheimer disease: how essential is the beta-amyloid link? Neurobiology of Aging. 15: 463-9; discussion 47. PMID 7969724 DOI: 10.1016/0197-4580(94)90079-5  0.433
1994 Nixon RA, Saito KI, Grynspan F, Griffin WR, Katayama S, Honda T, Mohan PS, Shea TB, Beermann M. Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Annals of the New York Academy of Sciences. 747: 77-91. PMID 7847693 DOI: 10.1111/J.1749-6632.1994.Tb44402.X  0.468
1994 Burke WJ, Galvin NJ, Chung HD, Stoff SA, Gillespie KN, Cataldo AM, Nixon RA. Degenerative changes in epinephrine tonic vasomotor neurons in Alzheimer's disease. Brain Research. 661: 35-42. PMID 7834382 DOI: 10.1016/0006-8993(94)91177-0  0.451
1994 Sihag RK, Wang LW, Cataldo AM, Hamlin M, Cohen CM, Nixon RA. Evidence for the association of protein 4.1 immunoreactive forms with neurofibrillary tangles in Alzheimer's disease brains. Brain Research. 656: 14-26. PMID 7804827 DOI: 10.1016/0006-8993(94)91361-7  0.417
1994 Nixon RA. Neuronal degenerative mechanisms as clues to pathogenesis and treatment of Alzheimer's disease. Neurobiology of Aging. 15: S61-5. PMID 7700464 DOI: 10.1016/0197-4580(94)90172-4  0.41
1994 Nixon RA, Paskevich PA, Sihag RK, Thayer CY. Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber. The Journal of Cell Biology. 126: 1031-46. PMID 7519617 DOI: 10.1083/Jcb.126.4.1031  0.307
1993 Nixon RA, Cataldo AM. The lysosomal system in neuronal cell death: a review. Annals of the New York Academy of Sciences. 679: 87-109. PMID 8512210 DOI: 10.1111/J.1749-6632.1993.Tb18291.X  0.342
1993 Saito K, Elce JS, Hamos JE, Nixon RA. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 90: 2628-32. PMID 8464868 DOI: 10.1073/Pnas.90.7.2628  0.471
1993 Leli U, Shea TB, Cataldo A, Hauser G, Grynspan F, Beermann ML, Liepkalns VA, Nixon RA, Parker PJ. Differential expression and subcellular localization of protein kinase C alpha, beta, gamma, delta, and epsilon isoforms in SH-SY5Y neuroblastoma cells: modifications during differentiation. Journal of Neurochemistry. 60: 289-98. PMID 8417148 DOI: 10.1111/J.1471-4159.1993.Tb05850.X  0.314
1993 Nixon RA. The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathobiology. Brain Pathology (Zurich, Switzerland). 3: 29-38. PMID 7505700 DOI: 10.1111/J.1750-3639.1993.Tb00723.X  0.323
1992 Shea TB, Beermann ML, Nixon RA. Sequential effects of astroglial-derived factors on neurite outgrowth: initiation by protease inhibitors and potentiation by extracellular matrix components. Journal of Neuroscience Research. 31: 309-17. PMID 1573681 DOI: 10.1002/Jnr.490310212  0.326
1992 Takeuchi KH, Saito KI, Nixon RA. Immunoassay and activity of calcium-activated neutral proteinase (mCANP): distribution in soluble and membrane-associated fractions in human and mouse brain. Journal of Neurochemistry. 58: 1526-32. PMID 1548485 DOI: 10.1111/J.1471-4159.1992.Tb11374.X  0.308
1992 Leli U, Cataldo A, Shea TB, Nixon RA, Hauser G. Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors. Journal of Neurochemistry. 58: 1191-8. PMID 1548459 DOI: 10.1111/J.1471-4159.1992.Tb11328.X  0.331
1992 Shea TB, Beermann ML, Nixon RA, Fischer I. Microtubule-associated protein tau is required for axonal neurite elaboration by neuroblastoma cells. Journal of Neuroscience Research. 32: 363-74. PMID 1433385 DOI: 10.1002/Jnr.490320308  0.362
1992 Shea TB, Beermann ML, Leli U, Nixon RA. Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C. Journal of Neuroscience Research. 33: 398-407. PMID 1335089 DOI: 10.1002/Jnr.490330306  0.312
1992 Nixon RA, Cataldo AM, Paskevich PA, Hamilton DJ, Wheelock TR, Kanaley-Andrews L. The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis. Annals of the New York Academy of Sciences. 674: 65-88. PMID 1288372 DOI: 10.1111/J.1749-6632.1992.Tb27478.X  0.496
1991 Cataldo AM, Paskevich PA, Kominami E, Nixon RA. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 88: 10998-1002. PMID 1837142 DOI: 10.1073/Pnas.88.24.10998  0.503
1991 Nixon RA, Sihag RK. Neurofilament phosphorylation: a new look at regulation and function. Trends in Neurosciences. 14: 501-6. PMID 1726767 DOI: 10.1016/0166-2236(91)90062-Y  0.352
1990 Cataldo AM, Thayer CY, Bird ED, Wheelock TR, Nixon RA. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin. Brain Research. 513: 181-92. PMID 2350688 DOI: 10.1016/0006-8993(90)90456-L  0.499
1990 Nixon RA, Clarke JF, Logvinenko KB, Tan MK, Hoult M, Grynspan F. Aluminum inhibits calpain-mediated proteolysis and induces human neurofilament proteins to form protease-resistant high molecular weight complexes. Journal of Neurochemistry. 55: 1950-9. PMID 2121904 DOI: 10.1111/J.1471-4159.1990.Tb05781.X  0.303
1990 Cataldo AM, Nixon RA. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proceedings of the National Academy of Sciences of the United States of America. 87: 3861-5. PMID 1692625 DOI: 10.1073/Pnas.87.10.3861  0.505
1989 Shea TB, Clarke JF, Wheelock TR, Paskevich PA, Nixon RA. Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/dl neuroblastoma. Brain Research. 492: 53-64. PMID 2752311 DOI: 10.1016/0006-8993(89)90888-3  0.314
1989 Nixon RA. Calcium-activated neutral proteinases as regulators of cellular function. Implications for Alzheimer's disease pathogenesis. Annals of the New York Academy of Sciences. 568: 198-208. PMID 2560900 DOI: 10.1111/J.1749-6632.1989.Tb12509.X  0.386
1988 Lewis SE, Nixon RA. Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: characterization and evidence for their differential association with stationary and moving neurofilaments. The Journal of Cell Biology. 107: 2689-701. PMID 3144556 DOI: 10.1083/Jcb.107.6.2689  0.32
1988 Shea TB, Nixon RA. Differential distribution of vimentin and neurofilament protein immunoreactivity in NB2a/d1 neuroblastoma cells following neurite retraction distinguishes two separate intermediate filament systems. Brain Research. 469: 298-302. PMID 2456847 DOI: 10.1016/0165-3806(88)90191-5  0.306
1987 Nixon RA, Lewis SE. Phosphorylation and dephosphorylation of neurofilament proteins in retinal ganglion cell neurons in vivo. Advances in Experimental Medicine and Biology. 221: 167-86. PMID 3124528 DOI: 10.1007/978-1-4684-7618-7_13  0.3
1987 Nixon RA, Lewis SE, Marotta CA. Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 1145-58. PMID 2437257 DOI: 10.1523/Jneurosci.07-04-01145.1987  0.308
1986 Zubenko GS, Marquis JK, Volicer L, Direnfeld LK, Langlais PJ, Nixon RA. Cerebrospinal fluid levels of angiotensin-converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: a correlative study. Biological Psychiatry. 21: 1365-81. PMID 3024746 DOI: 10.1016/0006-3223(86)90328-8  0.366
1985 Zubenko GS, Volicer L, Direnfeld LK, Freeman M, Langlais PJ, Nixon RA. Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy. Brain Research. 328: 215-21. PMID 2985183 DOI: 10.1016/0006-8993(85)91032-7  0.374
1984 Pope A, Nixon RA. Proteases of human brain. Neurochemical Research. 9: 291-323. PMID 6377107 DOI: 10.1007/Bf00963980  0.34
1983 Nixon RA, Brown BA, Marotta CA. Limited proteolytic modification of a neurofilament protein involves a proteinase activated by endogenous levels of calcium. Brain Research. 275: 384-8. PMID 6414649 DOI: 10.1016/0006-8993(83)91003-X  0.353
1982 Nixon RA, Brown BA, Marotta CA. Posttranslational modification of a neurofilament protein during axoplasmic transport: implications for regional specialization of CNS axons. The Journal of Cell Biology. 94: 150-8. PMID 6181078 DOI: 10.1083/Jcb.94.1.150  0.311
1980 Nixon RA. Protein degradation in the mouse visual system. I. Degradation of axonally transported and retinal proteins. Brain Research. 200: 69-83. PMID 6158362 DOI: 10.1016/0006-8993(80)91095-1  0.323
Show low-probability matches.