David Malcolm MacLean, PhD - Publications

Affiliations: 
2017- Pharmacology and Physiology University of Rochester Medical Center, Rochester, NY, United States 
Area:
Biophysics of iGluRs and ASICs, pharmacology
Website:
macleanlab.net

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Berger KD, MacLean DM. Mechanism of acid-sensing ion channel modulation by Hi1a. The Journal of General Physiology. 156. PMID 39446054 DOI: 10.1085/jgp.202313519  0.337
2024 Purohit R, Couch T, Rook ML, MacLean DM. Proline substitutions in the ASIC1 β11-12 linker slow desensitization. Biophysical Journal. PMID 39182166 DOI: 10.1016/j.bpj.2024.08.016  0.321
2024 Purohit R, Couch T, MacLean DM. Proline substitutions in the ASIC1 β11-12 linker slow desensitization. Biorxiv : the Preprint Server For Biology. PMID 38798386 DOI: 10.1101/2024.05.09.593312  0.33
2023 Allen JP, Garber KB, Perszyk R, Khayat CT, Kell SA, Kaneko M, Quindipan C, Saitta S, Ladda RL, Hewson S, Inbar-Feigenberg M, Prasad C, Prasad AN, Olewiler L, Mu W, ... ... MacLean DM, et al. Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants. Human Molecular Genetics. PMID 37944084 DOI: 10.1093/hmg/ddad188  0.302
2022 Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Reports. 38: 110308. PMID 35081351 DOI: 10.1016/j.celrep.2022.110308  0.526
2021 Rook ML, Ananchenko A, Musgaard M, MacLean DM. Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics. Frontiers in Cellular Neuroscience. 15: 761813. PMID 34924957 DOI: 10.3389/fncel.2021.761813  0.31
2021 Couch T, Berger K, Kneisley DL, McCullock TW, Kammermeier P, Maclean DM. Topography and motion of the acid-sensing ion channel intracellular domains. Elife. 10. PMID 34292153 DOI: 10.7554/eLife.68955  0.318
2021 Rook ML, Miaro M, Couch T, Kneisley DL, Musgaard M, MacLean DM. Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1. The Journal of General Physiology. 153. PMID 34061161 DOI: 10.1085/jgp.202012855  0.315
2020 Rook ML, Musgaard M, MacLean DM. Coupling structure with function in acid-sensing ion channels: Challenges in pursuit of proton sensors. The Journal of Physiology. PMID 32306405 DOI: 10.1113/Jp278707  0.432
2020 Rook ML, Williamson A, Lueck JD, Musgaard M, Maclean DM. β11-12 linker isomerization governs Acid-sensing ion channel desensitization and recovery. Elife. 9. PMID 32031522 DOI: 10.7554/Elife.51111  0.436
2020 Durham RJ, Paudyal N, Carrillo E, Bhatia NK, Maclean DM, Berka V, Dolino DM, Gorfe AA, Jayaraman V. Conformational spread and dynamics in allostery of NMDA receptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 32015122 DOI: 10.1073/Pnas.1910950117  0.684
2020 Rook ML, Williamson A, Lueck JD, Musgaard M, Maclean DM. Author response: β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery Elife. DOI: 10.7554/Elife.51111.Sa2  0.354
2020 Durham RJ, Paudyal N, Carrillo E, MacLean DM, Berka V, Dolino DM, Kaur Bhatia N, Gorfe AA, Jayaraman V. Role of Conformational Dynamics in NMDA Receptor Negative Cooperativity Biophysical Journal. 118: 586a. DOI: 10.1016/J.Bpj.2019.11.3178  0.639
2020 Rook ML, MacLean DM. Stoichiometry of Acid-Sensing Ion Channel (ASIC) Pharmacology Biophysical Journal. 118: 583a. DOI: 10.1016/J.Bpj.2019.11.3163  0.378
2019 Carrillo E, Shaikh SA, Berka V, Durham RJ, Litwin DB, Lee G, MacLean DM, Nowak LM, Jayaraman V. Mechanism of modulation of AMPA receptors by TARP-γ8. The Journal of General Physiology. PMID 31748249 DOI: 10.1016/J.Bpj.2019.11.1158  0.693
2018 MacLean DM, Durham RJ, Jayaraman V. Mapping the Conformational Landscape of Glutamate Receptors Using Single Molecule FRET. Trends in Neurosciences. PMID 30385052 DOI: 10.1016/J.Tins.2018.10.003  0.664
2018 Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Reports. 22: 2307-2321. PMID 29490268 DOI: 10.1016/J.Celrep.2018.02.021  0.515
2017 Dolino DM, Chatterjee S, MacLean DM, Flatebo C, Bishop LDC, Shaikh SA, Landes CF, Jayaraman V. The structure-energy landscape of NMDA receptor gating. Nature Chemical Biology. PMID 28991238 DOI: 10.1038/Nchembio.2487  0.699
2017 Coombs ID, MacLean DM, Jayaraman V, Farrant M, Cull-Candy SG. Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation. Cell Reports. 20: 1123-1135. PMID 28768197 DOI: 10.1016/J.Celrep.2017.07.014  0.649
2017 MacLean DM, Jayaraman V. Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive. Proceedings of the National Academy of Sciences of the United States of America. PMID 28265090 DOI: 10.1073/Pnas.1620508114  0.599
2017 MacLean DM, Jayaraman V. Acid Sensing Ion Channels have Agonist-Dependent Deactivation Biophysical Journal. 112: 420a. DOI: 10.1016/J.Bpj.2016.11.2246  0.581
2017 Musgaard M, MacLean DM, Litwin DB, Jayaraman V, Biggin PC. Investigating Coupling between Proton Sensors and Channel Motions in Acid-Sensing Ion Channels Biophysical Journal. 112: 420a. DOI: 10.1016/J.Bpj.2016.11.2245  0.543
2017 Litwin DB, MacLean DM, Jayaraman V. Reduced Structural Dynamics in Kainate Receptors through Auxiliary Protein Modulation Biophysical Journal. 112: 419a. DOI: 10.1016/J.Bpj.2016.11.2242  0.609
2017 Shaikh SA, Dolino DM, Lee G, Chatterjee S, MacLean DM, Flatebo C, Landes CF, Jayaraman V. AMPA Receptor Modulation by Stargazin Biophysical Journal. 112: 418a. DOI: 10.1016/J.Bpj.2016.11.2239  0.641
2016 Vitrac H, MacLean DM, Karlstaedt A, Taegtmeyer H, Jayaraman V, Bogdanov M, Dowhan W. Dynamic lipid-dependent modulation of protein topology by post-translational phosphorylation. The Journal of Biological Chemistry. PMID 27974465 DOI: 10.1074/Jbc.M116.765719  0.496
2016 Shaikh SA, Dolino DM, Lee G, Chatterjee S, MacLean DM, Flatebo C, Landes CF, Jayaraman V. Stargazin Modulation of AMPA Receptors. Cell Reports. 17: 328-335. PMID 27705782 DOI: 10.1016/J.Celrep.2016.09.014  0.691
2016 MacLean DM, Jayaraman V. Acid sensing ion channels are tuned to follow high frequency stimuli. The Journal of Physiology. PMID 26931316 DOI: 10.1113/Jp271915  0.56
2016 Litwin DB, Lee G, Maclean D, Jayaraman V. Modulation of Glutamate Receptors by Auxiliary Proteins a Structural Investigation Biophysical Journal. 110: 289a. DOI: 10.1016/J.Bpj.2015.11.1564  0.708
2016 MacLean DM, Jayaraman V. Acid Sensing Ion Channels are Uniquely Tuned to Follow High Frequency ‘Synaptic’ Stimuli Biophysical Journal. 110: 201a. DOI: 10.1016/J.Bpj.2015.11.1123  0.545
2015 Vitrac H, MacLean DM, Jayaraman V, Bogdanov M, Dowhan W. Dynamic membrane protein topological switching upon changes in phospholipid environment. Proceedings of the National Academy of Sciences of the United States of America. PMID 26512118 DOI: 10.1073/Pnas.1512994112  0.485
2015 Sirrieh RE, MacLean DM, Jayaraman V. A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc. The Journal of General Physiology. PMID 26170175 DOI: 10.1085/Jgp.201511422  0.696
2015 Sirrieh RE, MacLean DM, Jayaraman V. Subtype-dependent N-methyl-D-aspartate receptor amino-terminal domain conformations and modulation by spermine. The Journal of Biological Chemistry. 290: 12812-20. PMID 25829490 DOI: 10.1074/Jbc.M115.649723  0.686
2015 Ramaswamy SS, MacLean D, Sanabria H, Jayaraman V. Gating Mechanism and Movements in Acid Sensing Ion Channel 1A Biophysical Journal. 108: 288a. DOI: 10.1016/J.Bpj.2014.11.1573  0.612
2015 MacLean DM, Jayaraman V. The Structural Basis of Negative Cooperativity between Subunits of the NMDA Receptor Biophysical Journal. 108: 286a. DOI: 10.1016/J.Bpj.2014.11.1562  0.693
2015 Sirrieh RE, MacLean DM, Jayaraman V. Investigations of the Structural Mechanism of Modulation of the NMDA Receptor Biophysical Journal. 108: 285a. DOI: 10.1016/J.Bpj.2014.11.1557  0.716
2014 MacLean DM, Ramaswamy SS, Du M, Howe JR, Jayaraman V. Stargazin promotes closure of the AMPA receptor ligand-binding domain. The Journal of General Physiology. 144: 503-12. PMID 25422502 DOI: 10.1085/Jgp.201411287  0.688
2014 Lee G, MacLean DM, Ulrich H, Zhao X, Aronowski J, Jayaraman V. RNA based antagonist of NMDA receptors. Acs Chemical Neuroscience. 5: 559-67. PMID 24708087 DOI: 10.1021/Cn500041K  0.626
2014 Sirrieh RE, MacLean DM, Jayaraman V. Inter-Subunit Interactions of NMDA Receptor Amino-Terminal Domains Associated with Allosteric Modulation Biophysical Journal. 106: 152a. DOI: 10.1016/J.Bpj.2013.11.875  0.714
2013 Ramaswamy SS, MacLean DM, Gorfe AA, Jayaraman V. Proton-mediated conformational changes in an acid-sensing ion channel. The Journal of Biological Chemistry. 288: 35896-903. PMID 24196950 DOI: 10.1074/Jbc.M113.478982  0.619
2013 Sirrieh RE, MacLean DM, Jayaraman V. Amino-terminal domain tetramer organization and structural effects of zinc binding in the N-methyl-D-aspartate (NMDA) receptor. The Journal of Biological Chemistry. 288: 22555-64. PMID 23792960 DOI: 10.1074/Jbc.M113.482356  0.696
2013 MacLean DM. CrossTalk opposing view: TARPs modulate AMPA receptor conformations before the gating transitions. The Journal of Physiology. 591: 1585-6; discussion 1. PMID 23547187 DOI: 10.1113/Jphysiol.2012.247726  0.494
2013 Maclean DM. Rebuttal from David M. MacLean Journal of Physiology. 591: 1589. DOI: 10.1113/Jphysiol.2013.251520  0.374
2013 MacLean DM, Ramaswamy S, Howe JR, Jayaraman V. Towards a Mechanism of TARP Action at AMPA Receptors Biophysical Journal. 104: 543a. DOI: 10.1016/J.Bpj.2012.11.3007  0.693
2013 Sirrieh RE, MacLean DM, Jayaraman V. Arrangement of the N-Terminal Domains in NMDA Receptors Biophysical Journal. 104: 272a-273a. DOI: 10.1016/J.Bpj.2012.11.1529  0.707
2013 Ramaswamy SS, MacLean DM, Jayaraman V. Cleft Closure Mechanism in Gating of Acid Sensing Ion Channel 1A Biophysical Journal. 104: 270a. DOI: 10.1016/J.Bpj.2012.11.1516  0.607
2012 Ramaswamy S, Cooper D, Poddar N, MacLean DM, Rambhadran A, Taylor JN, Uhm H, Landes CF, Jayaraman V. Role of conformational dynamics in α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor partial agonism. The Journal of Biological Chemistry. 287: 43557-64. PMID 23115239 DOI: 10.1074/Jbc.M112.371815  0.774
2011 Maclean DM, Bowie D. Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation. The Journal of Physiology. 589: 5383-90. PMID 21969453 DOI: 10.1113/Jphysiol.2011.219485  0.706
2011 Maclean DM, Wong AY, Fay AM, Bowie D. Cations but not anions regulate the responsiveness of kainate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2136-44. PMID 21307250 DOI: 10.1523/Jneurosci.4314-10.2011  0.747
2010 MacLean D, Bowie D. TARP Modulation of AMPA Receptor Pharmacology: Polyamine Block and Competitive Antagonism Biophysical Journal. 98: 523a-524a. DOI: 10.1016/J.Bpj.2009.12.2845  0.68
2009 MacLean DM. The delta2 glutamate-like receptor undergoes similar conformational changes as other ionotropic glutamate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6767-8. PMID 19474303 DOI: 10.1523/Jneurosci.1456-09.2009  0.536
2007 Wong AY, MacLean DM, Bowie D. Na+/Cl- dipole couples agonist binding to kainate receptor activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6800-9. PMID 17581967 DOI: 10.1523/Jneurosci.0284-07.2007  0.726
2006 Kuang D, Yao Y, Maclean D, Wang M, Hampson DR, Chang BS. Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 103: 14050-5. PMID 16966606 DOI: 10.1073/Pnas.0604717103  0.558
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