Matthew A. Seager - Publications

Affiliations: 
Bristol-Myers Squibb Company, New York, NY, United States 
 Yale University, New Haven, CT 
Area:
Alzheimer's disease, schizophrenia, depression, learning, memory, cognition, hippocampus
Website:
http://www.linkedin.com/in/matthewseager

28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Yang ZQ, Shu Y, Ma L, Wittmann M, Ray WJ, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Kuduk SD. Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators. Acs Medicinal Chemistry Letters. 5: 604-8. PMID 24900888 DOI: 10.1021/ml500055h  0.96
2012 Kuduk SD, Chang RK, Greshock TJ, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators. Acs Medicinal Chemistry Letters. 3: 1070-4. PMID 24900430 DOI: 10.1021/ml300280g  0.96
2011 Kuduk SD, Chang RK, Di Marco CN, Pitts DR, Greshock TJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Ray WJ. Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold. Journal of Medicinal Chemistry. 54: 4773-80. PMID 21682298 DOI: 10.1021/jm200400m  0.96
2011 Kuduk SD, Chang RK, Di Marco CN, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series. Bioorganic & Medicinal Chemistry Letters. 21: 1710-5. PMID 21324684 DOI: 10.1016/j.bmcl.2011.01.094  0.96
2011 Kuduk SD, Di Marco CN, Cofre V, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Fused heterocyclic M1 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 21: 2769-72. PMID 21055928 DOI: 10.1016/j.bmcl.2010.10.028  0.96
2010 Kuduk SD, Chang RK, Di Marco CN, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators. Acs Medicinal Chemistry Letters. 1: 263-7. PMID 24900206 DOI: 10.1021/ml100095k  0.96
2010 Kuduk SD, DiPardo RM, Beshore DC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 2538-41. PMID 20346667 DOI: 10.1016/j.bmcl.2010.02.095  0.96
2010 Kuduk SD, Di Marco CN, Chang RK, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 2533-7. PMID 20303264 DOI: 10.1016/j.bmcl.2010.02.096  0.96
2010 Kuduk SD, Di Marco CN, Cofre V, Pitts DR, Ray WJ, Ma L, Wittmann M, Veng L, Seager MA, Koeplinger K, Thompson CD, Hartman GD, Bilodeau MT. N-heterocyclic derived M1 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 1334-7. PMID 20097564 DOI: 10.1016/j.bmcl.2010.01.013  0.96
2010 Zhao WQ, Santini F, Breese R, Ross D, Zhang XD, Stone DJ, Ferrer M, Townsend M, Wolfe AL, Seager MA, Kinney GG, Shughrue PJ, Ray WJ. Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. The Journal of Biological Chemistry. 285: 7619-32. PMID 20032460 DOI: 10.1074/jbc.M109.057182  0.96
2010 Yang FV, Shipe WD, Bunda JL, Nolt MB, Wisnoski DD, Zhao Z, Barrow JC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Hartman GD, Lindsley CW. Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 531-6. PMID 20004574 DOI: 10.1016/j.bmcl.2009.11.100  0.96
2010 Kuduk SD, Di Marco CN, Cofre V, Pitts DR, Ray WJ, Ma L, Wittmann M, Seager MA, Seager M, Koeplinger K, Thompson CD, Hartman GD, Bilodeau MT. Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding. Bioorganic & Medicinal Chemistry Letters. 20: 657-61. PMID 19962304 DOI: 10.1016/j.bmcl.2009.11.059  0.96
2010 Kuduk SD, Di Marco CN, Cofre V, Pitts DR, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger K, Thompson CD, Hartman GD, Bilodeau MT. Corrigendum to "Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding" [Bioorg. Med. Chem. Lett. 20 (2010) 657] (DOI:10.1016/j.bmcl.2009.11.059) Bioorganic and Medicinal Chemistry Letters. 20: 1796. DOI: 10.1016/j.bmcl.2010.01.027  0.96
2009 Ma L, Seager MA, Seager M, Wittmann M, Jacobson M, Bickel D, Burno M, Jones K, Graufelds VK, Xu G, Pearson M, McCampbell A, Gaspar R, Shughrue P, Danziger A, et al. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proceedings of the National Academy of Sciences of the United States of America. 106: 15950-5. PMID 19717450 DOI: 10.1073/pnas.0900903106  0.96
2009 Ma L, Seager MA, Wittmann M, Jacobson M, Bickel D, Burno M, Jones K, Graufelds VK, Xu G, Pearson M, McCampbell A, Gaspar R, Shughrue P, Danziger A, Regan C, et al. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, (15950-15955) DOI: 10.1073/pnas.0900903106) Proceedings of the National Academy of Sciences of the United States of America. 106: 18040. DOI: 10.1073/pnas.0910597106  0.96
2005 Asaka Y, Mauldin KN, Griffin AL, Seager MA, Shurell E, Berry SD. Nonpharmacological amelioration of age-related learning deficits: the impact of hippocampal theta-triggered training. Proceedings of the National Academy of Sciences of the United States of America. 102: 13284-8. PMID 16150707 DOI: 10.1073/pnas.0506515102  0.96
2005 Seager MA, Barth VN, Phebus LA, Rasmussen K. Chronic coadministration of olanzapine and fluoxetine activates locus coeruleus neurons in rats: implications for bipolar disorder. Psychopharmacology. 181: 126-33. PMID 15719213 DOI: 10.1007/s00213-005-2198-2  0.96
2005 Rasmussen K, Martin H, Berger JE, Seager MA. The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats. Neuropharmacology. 48: 173-80. PMID 15695156 DOI: 10.1016/j.neuropharm.2004.09.010  0.96
2004 Huff KD, Asaka Y, Griffin AL, Berg WP, Seager MA, Berry SD. Differential mastication kinematics of the rabbit in response to food and water: implications for conditioned movement. Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society. 39: 16-23. PMID 15379379  0.96
2004 Seager MA, Huff KD, Barth VN, Phebus LA, Rasmussen K. Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity. Biological Psychiatry. 55: 1103-9. PMID 15158430 DOI: 10.1016/j.biopsych.2004.02.012  0.96
2003 Seager MA, Smith-Bell CA, Schreurs BG. Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response: US intensity effects. Learning & Behavior. 31: 292-8. PMID 14577552  0.96
2002 Seager MA, Johnson LD, Chabot ES, Asaka Y, Berry SD. Oscillatory brain states and learning: Impact of hippocampal theta-contingent training. Proceedings of the National Academy of Sciences of the United States of America. 99: 1616-20. PMID 11818559 DOI: 10.1073/pnas.032662099  0.96
2001 Berry SD, Seager MA. Hippocampal theta oscillations and classical conditioning. Neurobiology of Learning and Memory. 76: 298-313. PMID 11726239 DOI: 10.1006/nlme.2001.4025  0.96
2001 Buck DL, Seager MA, Schreurs BG. Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response: generality and nature of the phenomenon. Behavioral Neuroscience. 115: 1039-47. PMID 11584916 DOI: 10.1037/0735-7044.115.5.1039  0.96
2000 Asaka Y, Seager MA, Griffin AL, Berry SD. Medial septal microinfusion of scopolamine disrupts hippocampal activity and trace jaw movement conditioning. Behavioral Neuroscience. 114: 1068-77. PMID 11142639 DOI: 10.1037//0735-7044.114.6.1068  0.96
1999 Seager MA, Asaka Y, Berry SD. Scopolamine disruption of behavioral and hippocampal responses in appetitive trace classical conditioning. Behavioural Brain Research. 100: 143-51. PMID 10212061 DOI: 10.1016/S0166-4328(98)00123-5  0.96
1998 Seager MA, Borgnis RL, Berry SD. Hippocampal age differences reoccur after modification of stimulus configurations in rabbit jaw movement conditioning. Neurobiology of Aging. 19: 277-81. PMID 9662004 DOI: 10.1016/S0197-4580(98)00061-X  0.96
1997 Seager MA, Borgnis RL, Berry SD. Delayed acquisition of behavioral and hippocampal responses during jaw movement conditioning in aging rabbits. Neurobiology of Aging. 18: 631-9. PMID 9461061 DOI: 10.1016/S0197-4580(97)00160-7  0.96
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