| Year |
Citation |
Score |
| 2019 |
Yoshida M, Satoh A, Lin JB, Mills KF, Sasaki Y, Rensing N, Wong M, Apte RS, Imai SI. Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. Cell Metabolism. PMID 31204283 DOI: 10.1016/J.Cmet.2019.05.015 |
0.377 |
|
| 2018 |
Snyder-Warwick AK, Satoh A, Santosa KB, Imai SI, Jablonka-Shariff A. Hypothalamic Sirt1 protects terminal Schwann cells and neuromuscular junctions from age-related morphological changes. Aging Cell. e12776. PMID 29851253 DOI: 10.1111/Acel.12776 |
0.322 |
|
| 2018 |
Johnson S, Imai SI. NAD biosynthesis, aging, and disease. F1000research. 7: 132. PMID 29744033 DOI: 10.12688/F1000Research.12120.1 |
0.358 |
|
| 2017 |
Satoh A, Imai SI, Guarente L. The brain, sirtuins, and ageing. Nature Reviews. Neuroscience. 18: 362-374. PMID 28515492 DOI: 10.1038/Nrn.2017.42 |
0.307 |
|
| 2016 |
Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metabolism. 24: 795-806. PMID 28068222 DOI: 10.1016/j.cmet.2016.09.013 |
0.304 |
|
| 2016 |
Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai SI, Yoshino J. NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice. Cell Reports. PMID 27498863 DOI: 10.1016/J.Celrep.2016.07.027 |
0.585 |
|
| 2016 |
de Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai SI, Seals DR. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. PMID 26970090 DOI: 10.1111/Acel.12461 |
0.608 |
|
| 2015 |
Stein LR, Zorumski CF, Imai SI, Izumi Y. Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors. Brain Research Bulletin. PMID 26481044 DOI: 10.1016/J.Brainresbull.2015.10.005 |
0.317 |
|
| 2015 |
Yoon MJ, Yoshida M, Johnson S, Takikawa A, Usui I, Tobe K, Nakagawa T, Yoshino J, Imai S. SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice. Cell Metabolism. 21: 706-17. PMID 25921090 DOI: 10.1016/J.Cmet.2015.04.002 |
0.64 |
|
| 2015 |
Ghisays F, Brace CS, Yackly SM, Kwon HJ, Mills KF, Kashentseva E, Dmitriev IP, Curiel DT, Imai SI, Ellenberger T. The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs. Cell Reports. PMID 25772354 DOI: 10.1016/J.Celrep.2015.02.036 |
0.403 |
|
| 2015 |
Satoh A, Brace CS, Rensing N, Imai S. Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity. Aging Cell. 14: 209-18. PMID 25546159 DOI: 10.1111/Acel.12299 |
0.351 |
|
| 2014 |
Yoshino J, Almeda-Valdes P, Patterson BW, Okunade AL, Imai S, Mittendorfer B, Klein S. Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. The Journal of Clinical Endocrinology and Metabolism. 99: E1666-70. PMID 24878055 DOI: 10.1210/Jc.2014-1579 |
0.392 |
|
| 2014 |
Stein LR, Imai S. Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging. The Embo Journal. 33: 1321-40. PMID 24811750 DOI: 10.1002/Embj.201386917 |
0.361 |
|
| 2014 |
Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 24: 464-71. PMID 24786309 DOI: 10.1016/J.Tcb.2014.04.002 |
0.386 |
|
| 2014 |
Stein LR, Wozniak DF, Dearborn JT, Kubota S, Apte RS, Izumi Y, Zorumski CF, Imai S. Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 5800-15. PMID 24760840 DOI: 10.1523/Jneurosci.4730-13.2014 |
0.321 |
|
| 2013 |
Yoshino J, Imai S. Accurate measurement of nicotinamide adenine dinucleotide (NAD⁺) with high-performance liquid chromatography. Methods in Molecular Biology (Clifton, N.J.). 1077: 203-15. PMID 24014409 DOI: 10.1007/978-1-62703-637-5_14 |
0.348 |
|
| 2013 |
Satoh A, Brace CS, Rensing N, Cliften P, Wozniak DF, Herzog ED, Yamada KA, Imai S. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metabolism. 18: 416-30. PMID 24011076 DOI: 10.1016/J.Cmet.2013.07.013 |
0.414 |
|
| 2013 |
Imai S, Yoshino J. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes, Obesity & Metabolism. 15: 26-33. PMID 24003918 DOI: 10.1111/Dom.12171 |
0.498 |
|
| 2012 |
Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, Gu C, Kunz I, Rossi Fanelli F, Patterson BW, Klein S. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metabolism. 16: 658-64. PMID 23102619 DOI: 10.1016/J.Cmet.2012.09.015 |
0.377 |
|
| 2012 |
Stein LR, Imai S. The dynamic regulation of NAD metabolism in mitochondria. Trends in Endocrinology and Metabolism: Tem. 23: 420-8. PMID 22819213 DOI: 10.1016/J.Tem.2012.06.005 |
0.344 |
|
| 2011 |
Yoshino J, Imai S. Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome. Molecular Cell. 44: 170-1. PMID 22017865 DOI: 10.1016/J.Molcel.2011.10.005 |
0.317 |
|
| 2011 |
Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism. 14: 528-36. PMID 21982712 DOI: 10.1016/J.Cmet.2011.08.014 |
0.659 |
|
| 2011 |
Imai S. Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. Febs Letters. 585: 1657-62. PMID 21550345 DOI: 10.1016/J.Febslet.2011.04.060 |
0.373 |
|
| 2011 |
Grimm AA, Brace CS, Wang T, Stormo GD, Imai S. A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression. Aging Cell. 10: 305-17. PMID 21176092 DOI: 10.1111/J.1474-9726.2010.00667.X |
0.397 |
|
| 2010 |
Imai S. Toward productive aging: SIRT1, systemic NAD biosynthesis, and the NAD world. Cornea. 29: S7-12. PMID 20935547 DOI: 10.1097/Ico.0B013E3181Ea4714 |
0.387 |
|
| 2010 |
Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/Science.329.5995.1012 |
0.36 |
|
| 2010 |
Yoshino J, Imai S. A clock ticks in pancreatic beta cells. Cell Metabolism. 12: 107-8. PMID 20674854 DOI: 10.1016/J.Cmet.2010.07.006 |
0.379 |
|
| 2010 |
Satoh A, Brace CS, Ben-Josef G, West T, Wozniak DF, Holtzman DM, Herzog ED, Imai S. SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10220-32. PMID 20668205 DOI: 10.1523/Jneurosci.1385-10.2010 |
0.393 |
|
| 2010 |
Imai S, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends in Pharmacological Sciences. 31: 212-20. PMID 20226541 DOI: 10.1016/J.Tips.2010.02.003 |
0.397 |
|
| 2010 |
Imai S. A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacological Research. 62: 42-7. PMID 20085812 DOI: 10.1016/J.Phrs.2010.01.006 |
0.389 |
|
| 2010 |
Imai S. "Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochimica Et Biophysica Acta. 1804: 1584-90. PMID 19897060 DOI: 10.1016/J.Bbapap.2009.10.024 |
0.425 |
|
| 2009 |
Imai S. SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty. Current Opinion in Clinical Nutrition and Metabolic Care. 12: 350-6. PMID 19474721 DOI: 10.1097/Mco.0B013E32832C932D |
0.354 |
|
| 2009 |
Imai S. From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis. Biochimica Et Biophysica Acta. 1790: 997-1004. PMID 19289152 DOI: 10.1016/J.Bbagen.2009.03.005 |
0.386 |
|
| 2009 |
Imai S, Kiess W. Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Frontiers in Bioscience (Landmark Edition). 14: 2983-95. PMID 19273250 DOI: 10.2741/3428 |
0.4 |
|
| 2009 |
Imai S. Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Current Pharmaceutical Design. 15: 20-8. PMID 19149599 DOI: 10.2174/138161209787185814 |
0.412 |
|
| 2009 |
Imai S. The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance. Cell Biochemistry and Biophysics. 53: 65-74. PMID 19130305 DOI: 10.1007/S12013-008-9041-4 |
0.417 |
|
| 2009 |
Garten A, Petzold S, Körner A, Imai S, Kiess W. Nampt: linking NAD biology, metabolism and cancer. Trends in Endocrinology and Metabolism: Tem. 20: 130-8. PMID 19109034 DOI: 10.1016/J.Tem.2008.10.004 |
0.457 |
|
| 2008 |
Ramsey KM, Mills KF, Satoh A, Imai SI. Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice Aging Cell. 7: 78-88. PMID 18005249 DOI: 10.1111/J.1474-9726.2007.00355.X |
0.478 |
|
| 2008 |
Imai S, Guarente LP. 2 Sirtuins: A Universal Link between NAD, Metabolism, and Aging Cold Spring Harbor Monograph Archive. 51: 39-72. DOI: 10.1101/087969824.51.39 |
0.318 |
|
| 2007 |
Revollo JR, Körner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metabolism. 6: 363-75. PMID 17983582 DOI: 10.1016/J.Cmet.2007.09.003 |
0.703 |
|
| 2007 |
Imai S. Is Sirt1 a miracle bullet for longevity? Aging Cell. 6: 735-7. PMID 17941969 DOI: 10.1111/J.1474-9726.2007.00344.X |
0.409 |
|
| 2007 |
Revollo JR, Grimm AA, Imai S. The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals. Current Opinion in Gastroenterology. 23: 164-70. PMID 17268245 DOI: 10.1097/Mog.0B013E32801B3C8F |
0.711 |
|
| 2006 |
Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C. Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nature Structural & Molecular Biology. 13: 661-2. PMID 16783373 DOI: 10.1038/Nsmb1114 |
0.654 |
|
| 2006 |
Moynihan KA, Imai Si. Sirt1 as a key regulator orchestrating the response to caloric restriction Drug Discovery Today: Disease Mechanisms. 3: 11-17. DOI: 10.1016/J.Ddmec.2006.02.005 |
0.663 |
|
| 2005 |
Pillai JB, Isbatan A, Imai S, Gupta MP. Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. The Journal of Biological Chemistry. 280: 43121-30. PMID 16207712 DOI: 10.1074/Jbc.M506162200 |
0.303 |
|
| 2005 |
Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Méneur C, Permutt MA, Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metabolism. 2: 105-17. PMID 16098828 DOI: 10.1016/J.Cmet.2005.07.001 |
0.683 |
|
| 2004 |
Revollo JR, Grimm AA, Imai S. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. The Journal of Biological Chemistry. 279: 50754-63. PMID 15381699 DOI: 10.1074/jbc.M408388200 |
0.701 |
|
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