Guido Silvestri - Publications

Affiliations: 
Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Immunology

298 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wang Q, Clark KM, Tiwari R, Raju N, Tharp GK, Rogers J, Harris RA, Raveendran M, Bosinger SE, Burdo TH, Silvestri G, Shan L. The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression. Cell. 187: 1223-1237.e16. PMID 38428396 DOI: 10.1016/j.cell.2024.01.048  0.599
2023 Ling L, De C, Spagnuolo RA, Begum N, Falcinelli SD, Archin NM, Kovarova M, Silvestri G, Wahl A, Margolis DM, Garcia JV. Transient CD4+ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice. Plos Pathogens. 19: e1011824. PMID 38055722 DOI: 10.1371/journal.ppat.1011824  0.533
2023 Laliberté A, Prelli Bozzo C, Stahl-Hennig C, Hunszinger V, Joas S, Sauermann U, Roshani B, Klippert A, Daskalaki M, Mätz-Rensing K, Stolte-Leeb N, Tharp GK, Fuchs D, Gupta PM, Silvestri G, et al. Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIV in rhesus macaques. Iscience. 26: 108351. PMID 38025783 DOI: 10.1016/j.isci.2023.108351  0.441
2023 Phung I, Rodrigues KA, Marina-Zárate E, Maiorino L, Pahar B, Lee WH, Melo M, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Lopez PG, ... ... Silvestri G, et al. A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates. Nature Communications. 14: 7107. PMID 37925510 DOI: 10.1038/s41467-023-42923-x  0.325
2023 Dashti A, Sukkestad S, Horner AM, Neja M, Siddiqi Z, Waller C, Goldy J, Monroe D, Lin A, Schoof N, Singh V, Mavigner M, Lifson JD, Deleage C, Tuyishime M, ... ... Silvestri G, et al. AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques. Nature Medicine. 29: 2535-2546. PMID 37783968 DOI: 10.1038/s41591-023-02570-7  0.491
2023 Viox EG, Hoang TN, Upadhyay AA, Nchioua R, Hirschenberger M, Strongin Z, Tharp GK, Pino M, Nguyen K, Harper JL, Gagne M, Marciano S, Boddapati AK, Pellegrini KL, Pradhan A, ... ... Silvestri G, et al. Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques. Science Immunology. 8: eadg0033. PMID 37506197 DOI: 10.1126/sciimmunol.adg0033  0.308
2023 Mainou E, Berendam SJ, Obregon-Perko V, Uffman EA, Phan CT, Shaw GM, Bar KJ, Kumar MR, Fray EJ, Siliciano JM, Siliciano RF, Silvestri G, Permar SR, Fouda GG, McCarthy J, et al. Assessing the effect of antibody responses on viral rebound dynamics in postnatally SHIV-infected infant Rhesus macaques. Biorxiv : the Preprint Server For Biology. PMID 37502921 DOI: 10.1101/2023.07.22.550159  0.387
2023 Samer S, Chowdhury A, Wiche Salinas TR, Estrada PMDR, Reuter M, Tharp G, Bosinger S, Cervasi B, Auger J, Gill K, Ablanedo-Terrazas Y, Reyes-Teran G, Estes JD, Betts MR, Silvestri G, et al. Lymph-Node-Based CD3 CD20 Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection. Journal of Virology. e0176022. PMID 37223960 DOI: 10.1128/jvi.01760-22  0.598
2023 De C, Pickles RJ, Yao W, Liao B, Boone AE, Choi M, Battaglia DM, Askin FB, Whitmire JK, Silvestri G, Garcia JV, Wahl A. Human T cells efficiently control RSV infection. Jci Insight. PMID 37159271 DOI: 10.1172/jci.insight.168110  0.429
2023 Mutascio S, Mota T, Franchitti L, Sharma AA, Willemse A, Bergstresser SN, Wang H, Statzu M, Tharp GK, Weiler J, Sékaly RP, Bosinger SE, Paiardini M, Silvestri G, Jones RB, et al. CD8 T cells promote HIV latency by remodeling CD4 T cell metabolism to enhance their survival, quiescence, and stemness. Immunity. PMID 37030290 DOI: 10.1016/j.immuni.2023.03.010  0.568
2023 Statzu M, Jin W, Fray EJ, Wong AKH, Kumar MR, Ferrer E, Docken SS, Pinkevych M, McBrien JB, Fennessey CM, Keele BF, Liang S, Harper JL, Mutascio S, Franchitti L, ... ... Silvestri G, et al. CD8 lymphocytes do not impact SIV reservoir establishment under ART. Nature Microbiology. PMID 36690860 DOI: 10.1038/s41564-022-01311-9  0.568
2022 Hoang TN, Viox EG, Upadhyay AA, Strongin Z, Tharp GK, Pino M, Nchioua R, Hirschenberger M, Gagne M, Nguyen K, Harper JL, Marciano S, Boddapati AK, Pellegrini KL, Tisoncik-Go J, ... ... Silvestri G, et al. Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques. Biorxiv : the Preprint Server For Biology. PMID 36324810 DOI: 10.1101/2022.10.21.512606  0.323
2022 Strongin Z, Hoang TN, Tharp GK, Rahmberg AR, Harper JL, Nguyen K, Franchitti L, Cervasi B, Lee M, Zhang Z, Boritz EA, Silvestri G, Marconi VC, Bosinger SE, Brenchley JM, et al. The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence. Plos Pathogens. 18: e1010723. PMID 35867722 DOI: 10.1371/journal.ppat.1010723  0.536
2022 Harper J, Ribeiro SP, Chan CN, Aid M, Deleage C, Micci L, Pino M, Cervasi B, Raghunathan G, Rimmer E, Ayanoglu G, Wu G, Shenvi N, Barnard RJ, Del Prete GQ, ... ... Silvestri G, et al. Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy. The Journal of Clinical Investigation. PMID 35230978 DOI: 10.1172/JCI155251  0.413
2022 Singh V, Obregon-Perko V, Lapp SA, Horner AM, Brooks A, Macoy L, Hussaini L, Lu A, Gibson T, Silvestri G, Grifoni A, Weiskopf D, Sette A, Anderson EJ, Rostad CA, et al. Limited induction of SARS-CoV-2-specific T cell responses in children with multisystem inflammatory syndrome compared to COVID-19. Jci Insight. PMID 35044955 DOI: 10.1172/jci.insight.155145  0.319
2021 Obregon-Perko V, Bricker KM, Mensah G, Uddin F, Rotolo L, Vanover D, Desai Y, Santangelo PJ, Jean S, Wood JS, Connor-Stroud FC, Ehnert S, Berendam SJ, Liang S, Vanderford TH, ... ... Silvestri G, et al. Dynamics and origin of rebound viremia in SHIV-infected infant macaques following interruption of long-term ART. Jci Insight. PMID 34699383 DOI: 10.1172/jci.insight.152526  0.456
2021 Tuyishime M, Dashti A, Faircloth K, Jha S, Nordstrom JL, Haynes BF, Silvestri G, Chahroudi A, Margolis DM, Ferrari G. Elimination of SHIV Infected Cells by Combinations of Bispecific HIVxCD3 DART Molecules. Frontiers in Immunology. 12: 710273. PMID 34484212 DOI: 10.3389/fimmu.2021.710273  0.547
2021 Kulpa DA, Silvestri G. Introduction to the Special Issue: Immunology of HIV and SIV infection. Seminars in Immunology. 101484. PMID 34340888 DOI: 10.1016/j.smim.2021.101484  0.41
2021 Lee MY, Upadhyay AA, Walum H, Chan CN, Dawoud RA, Grech C, Harper JL, Karunakaran KA, Nelson SA, Mahar EA, Goss KL, Carnathan DG, Cervasi B, Gill K, Tharp GK, ... ... Silvestri G, et al. Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection. Plos Pathogens. 17: e1009674. PMID 34181694 DOI: 10.1371/journal.ppat.1009674  0.47
2021 Harper J, Huot N, Micci L, Tharp G, King C, Rascle P, Shenvi N, Wang H, Galardi C, Upadhyay AA, Villinger F, Lifson J, Silvestri G, Easley K, Jacquelin B, et al. IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques. Nature Communications. 12: 2866. PMID 34001890 DOI: 10.1038/s41467-021-23189-7  0.392
2021 Mavigner M, Liao LE, Brooks AD, Ke R, Mattingly C, Schoof N, McBrien J, Carnathan D, Liang S, Vanderford TH, Paiardini M, Kulpa D, Lifson JD, Dunham RM, Easley KA, ... ... Silvestri G, et al. CD8 lymphocyte depletion enhances the latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques. Journal of Virology. PMID 33568515 DOI: 10.1128/JVI.01429-20  0.55
2020 Obregon-Perko V, Bricker K, Mensah G, Uddin F, Kumar M, Fray E, Siliciano RF, Schoof N, Horner A, Mavigner M, Liang S, Vanderford T, Sass J, Chan C, Berendam SJ, ... ... Silvestri G, et al. SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques is Characterized by Elevated SHIV RNA in the Gut and High Abundance of Intact SHIV DNA in Naïve CD4+ T cells. Journal of Virology. PMID 33087463 DOI: 10.1128/JVI.01669-20  0.558
2020 Zanoni M, Palesch D, Pinacchio C, Statzu M, Tharp GK, Paiardini M, Chahroudi A, Bosinger SE, Yoon J, Cox B, Silvestri G, Kulpa DA. Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription. Plos Pathogens. 16: e1008821. PMID 32941545 DOI: 10.1371/Journal.Ppat.1008821  0.646
2020 Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, ... ... Silvestri G, et al. Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathogens. 16: e1008753. PMID 32866207 DOI: 10.1371/Journal.Ppat.1008753  0.394
2020 Dashti A, Waller C, Mavigner M, Schoof N, Bar KJ, Shaw GM, Vanderford T, Liang S, Lifson J, Dunham RM, Ferrari G, Tuyishime M, Lam CK, Nordstrom JL, Margolis DM, ... Silvestri G, et al. SMAC mimetic plus triple combination bispecific HIVxCD3 DART® molecules in SHIV.C.CH505-infected, ART-suppressed rhesus macaques. Journal of Virology. PMID 32817214 DOI: 10.1128/Jvi.00793-20  0.544
2020 Garcia-Mesa Y, Garza R, Diaz Ortiz ME, Gruenewald AL, Bastien BL, Lobrovich R, Irwin DJ, Betts MR, Silvestri G, Kolson DL. Regional brain recovery from acute synaptic injury in SIV-infected rhesus macaques associates with heme oxygenase isoform expression. Journal of Virology. PMID 32669339 DOI: 10.1128/Jvi.01102-20  0.335
2020 McBrien JB, Wong AKH, White E, Carnathan DG, Lee JH, Safrit JT, Vanderford TH, Paiardini M, Chahroudi A, Silvestri G. Combination of CD8β depletion and IL-15 superagonist N-803 induces virus reactivation in SHIV-infected, long-term ART-treated rhesus macaques. Journal of Virology. PMID 32669328 DOI: 10.1128/Jvi.00755-20  0.624
2020 Carnathan DG, Kaushik K, Ellebedy AH, Enemuo CA, Gebru EH, Dhadvai P, Rasheed MAU, Pauthner MG, Ozorowski G, Ahmed R, Burton DR, Ward AB, Silvestri G, Crotty S, Locci M. Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers. Frontiers in Immunology. 11: 1213. PMID 32612608 DOI: 10.3389/Fimmu.2020.01213  0.464
2020 Clementi N, Ferrarese R, Tonelli M, Amato V, Racca S, Locatelli M, Lippi G, Silvestri G, Clementi M, Mancini N. Lower nasopharyngeal viral load during the latest phase of COVID-19 pandemic in a Northern Italy University Hospital. Clinical Chemistry and Laboratory Medicine. PMID 32598306 DOI: 10.1515/Cclm-2020-0815  0.312
2020 Strongin Z, Micci L, Fromentin R, Harper J, McBrien J, Ryan E, Shenvi N, Easley K, Chomont N, Silvestri G, Paiardini M. Virologic and immunologic features of SIV control post ART interruption in rhesus macaques. Journal of Virology. PMID 32350073 DOI: 10.1128/Jvi.00338-20  0.573
2020 Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, ... ... Silvestri G, et al. CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption. Nature Medicine. 26: 519-528. PMID 32284611 DOI: 10.1038/S41591-020-0782-Y  0.5
2020 Shytaj IL, Lucic B, Forcato M, Penzo C, Billingsley J, Laketa V, Bosinger S, Stanic M, Gregoretti F, Antonelli L, Oliva G, Frese CK, Trifunovic A, Galy B, Eibl C, ... Silvestri G, et al. Alterations of redox and iron metabolism accompany the development of HIV latency. The Embo Journal. e102209. PMID 32157726 DOI: 10.15252/Embj.2019102209  0.494
2020 Joas S, Sauermann U, Roshani B, Klippert A, Daskalaki M, Mätz-Rensing K, Stolte-Leeb N, Heigele A, Tharp GK, Gupta PM, Nelson S, Bosinger S, Parodi L, Giavedoni L, Silvestri G, et al. Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion. Cell Reports. 30: 2261-2274.e7. PMID 32075764 DOI: 10.1016/J.Celrep.2020.01.069  0.613
2020 McBrien JB, Mavigner M, Franchitti L, Smith SA, White E, Tharp GK, Walum H, Busman-Sahay K, Aguilera-Sandoval CR, Thayer WO, Spagnuolo RA, Kovarova M, Wahl A, Cervasi B, Margolis DM, ... ... Silvestri G, et al. Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8 cells. Nature. PMID 32015546 DOI: 10.1038/S41586-020-2002-9  0.5
2020 Nixon CC, Mavigner M, Sampey GC, Brooks AD, Spagnuolo RA, Irlbeck DM, Mattingly C, Ho PT, Schoof N, Cammon CG, Tharp GK, Kanke M, Wang Z, Cleary RA, Upadhyay AA, ... ... Silvestri G, et al. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. Nature. PMID 31969707 DOI: 10.1038/S41586-020-1951-3  0.525
2020 McBrien JB, Mavigner M, Franchitti L, Smith SA, White E, Tharp GK, Walum H, Busman-Suhay K, Aguilera-Sandoval CR, Thayer WO, Spagnuolo RA, Kovarova M, Wahl A, Cervasi B, Margolis DM, ... ... Silvestri G, et al. Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8 cells. Nature. PMID 31969705 DOI: 10.1038/S41586-020-1946-0  0.625
2019 Chamcha V, Reddy PBJ, Kannanganat S, Wilkins C, Gangadhara S, Velu V, Green R, Law GL, Chang J, Bowen JR, Kozlowski PA, Lifton M, Santra S, Legere T, Chea LS, ... ... Silvestri G, et al. Strong T1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy. Science Translational Medicine. 11. PMID 31748228 DOI: 10.1126/Scitranslmed.Aav1800  0.569
2019 Rabezanahary H, Moukambi F, Palesch D, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Zghidi-Abouzid O, Soundaramourty C, Tremblay C, Silvestri G, Estaquier J. Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques. Mucosal Immunology. PMID 31723251 DOI: 10.1038/S41385-019-0221-X  0.572
2019 Havenar-Daughton C, Carnathan DG, Boopathy AV, Upadhyay AA, Murrell B, Reiss SM, Enemuo CA, Gebru EH, Choe Y, Dhadvai P, Viviano F, Kaushik K, Bhiman JN, Briney B, Burton DR, ... ... Silvestri G, et al. Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization. Cell Reports. 29: 1756-1766.e8. PMID 31722194 DOI: 10.1016/J.Celrep.2019.10.008  0.352
2019 Barrenas F, Raehtz K, Xu C, Law L, Green RR, Silvestri G, Bosinger SE, Nishida A, Li Q, Lu W, Zhang J, Thomas MJ, Chang J, Smith E, Weiss JM, et al. Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control. Nature Communications. 10: 5101. PMID 31704931 DOI: 10.1038/S41467-019-12987-9  0.367
2019 Pino M, Paganini S, Deleage C, Padhan K, Harper JL, King CT, Micci L, Cervasi B, Mudd JC, Gill KP, Jean SM, Easley K, Silvestri G, Estes JD, Petrovas C, et al. Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence. Plos Pathogens. 15: e1008081. PMID 31626660 DOI: 10.1371/Journal.Ppat.1008081  0.614
2019 Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, Pauthner MG, Reiss S, Cottrell CA, Smith ML, ... ... Silvestri G, et al. Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance. Cell. PMID 31080066 DOI: 10.1016/J.Cell.2019.04.012  0.426
2019 Brody IB, Calcedo R, Connell MJ, Carnathan DG, Nason M, Lawson BO, Nega MT, Boyd S, Qin Q, Vanderford TH, Wilson JM, Wilson JM, Silvestri G, Betts MR. Susceptibility to SIV Infection After Adenoviral Vaccination in a Low Dose Rhesus Macaque Challenge Model. Pathogens & Immunity. 4: 1-20. PMID 30993250 DOI: 10.20411/pai.v4i1.241  0.48
2019 McBrien JB, Carnathan DG, White E, Lifson J, Lee JH, Safrit JT, Paiardini M, Chahroudi A, Silvestri G. Sustained SHIV reactivation by N-803 in ART-treated CD8-depleted macaques Journal of Virus Eradication. 5: 15-16. DOI: 10.1016/S2055-6640(20)31052-9  0.41
2019 Mavigner M, Brooks AD, Tharp GK, Mattingly C, Schoof N, Vanderford TH, Bosinger SE, Sampey GC, Galardi C, Dunham RM, Margolis DM, Silvestri G, Chahroudi A. CD8 depletion plus signaling of the non-canonical NF-kB pathway reverses latency in SIV-infected, ART-suppressed rhesus macaques Journal of Virus Eradication. 5: 15. DOI: 10.1016/S2055-6640(20)31050-5  0.474
2019 Mavigner M, Brooks AD, Koblansky A, Galardi C, Madsen H, Margolis DM, Silvestri G, Chahroudi A. Sting agonist as a kick and kill agent to target the HIV reservoir Journal of Virus Eradication. 5: 14-15. DOI: 10.1016/S2055-6640(20)31049-9  0.362
2019 Franchitti L, Zhang Z, Yoon J, Paiardini M, Silvestri G, Kulpa DA. Unprimed CD8 lymphocytes promote the establishment of HIV latency in CD4 T cells Journal of Virus Eradication. 5: 19-20. DOI: 10.1016/S2055-6640(20)30121-7  0.566
2019 Mavigner M, Brooks A, Mattingly C, Vanderford T, Keele B, Lifson J, Dunham R, Margolis D, Silvestri G, Chahroudi A. The latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques is potentiated by CD8a cell depletion Journal of Virus Eradication. 5: 17. DOI: 10.1016/S2055-6640(20)30113-8  0.495
2018 Cao Y, Cartwright EK, Silvestri G, Perelson AS. CD8+ lymphocyte control of SIV infection during antiretroviral therapy. Plos Pathogens. 14: e1007350. PMID 30308068 DOI: 10.1371/Journal.Ppat.1007350  0.544
2018 Hoang TN, Harper JL, Pino MC, Wang H, Micci L, King CT, McGary CS, McBrien JB, Cervasi B, Silvestri G, Paiardini M. Bone marrow-derived CD4 T cells are depleted in SIV-infected macaques and contribute to the size of the replication competent reservoir on ART. Journal of Virology. PMID 30305357 DOI: 10.1128/Jvi.01344-18  0.642
2018 Kumar NA, McBrien JB, Carnathan DG, Mavigner M, Mattingly C, White ER, Viviano F, Bosinger SE, Chahroudi A, Silvestri G, Paiardini M, Vanderford TH. Antibody-mediated CD4 depletion induces homeostatic CD4+ T cell proliferation without detectable virus reactivation in ART-treated SIV-infected macaques. Journal of Virology. PMID 30185596 DOI: 10.1128/Jvi.01235-18  0.64
2018 Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, ... Silvestri G, et al. SIV persistence in cellular and anatomic reservoirs in ART-suppressed infant rhesus macaques. Journal of Virology. PMID 29997216 DOI: 10.1128/Jvi.00562-18  0.475
2018 Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, ... ... Silvestri G, et al. Identification and characterization of HIV-specific resident memory CD8 T cells in human lymphoid tissue. Science Immunology. 3. PMID 29858286 DOI: 10.1126/Sciimmunol.Aar4526  0.596
2018 Zanoni M, Palesch D, Silvestri G. Longing for HIV protection. Nature Microbiology. 3: 648-649. PMID 29784974 DOI: 10.1038/S41564-018-0169-8  0.434
2018 Palesch D, Bosinger SE, Mavigner M, Billingsley JM, Mattingly C, Carnathan D, Paiardini M, Chahroudi A, Vanderford T, Silvestri G. Short-term pIFN-α2a treatment does not significantly reduce the viral reservoir of SIV-infected, ART-treated rhesus macaques. Journal of Virology. PMID 29720521 DOI: 10.1128/Jvi.00279-18  0.568
2018 Tuyishime S, Haut LH, Kurupati RK, Billingsley JM, Carnathan D, Gangahara S, Styles TM, Xiang Z, Li Y, Zopfs M, Liu Q, Zhou X, Lewis MG, Amara RR, Bosinger S, ... Silvestri G, et al. Correlates of Protection Against SIV Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors. Ebiomedicine. PMID 29685793 DOI: 10.1016/J.Ebiom.2018.02.025  0.512
2018 Wetzel KS, Yi Y, Yadav A, Bauer AM, Bello EA, Romero DC, Bibollet-Ruche F, Hahn BH, Paiardini M, Silvestri G, Peeters M, Collman RG. Loss of CXCR6 coreceptor usage characterizes pathogenic lentiviruses. Plos Pathogens. 14: e1007003. PMID 29659623 DOI: 10.1371/Journal.Ppat.1007003  0.574
2018 Joas S, Parrish EH, Gnanadurai CW, Lump E, Stürzel CM, Parrish NF, Learn GH, Sauermann U, Neumann B, Rensing KM, Fuchs D, Billingsley JM, Bosinger SE, Silvestri G, Apetrei C, et al. Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity. Nature Communications. 9: 1371. PMID 29636452 DOI: 10.1038/S41467-018-03762-3  0.513
2018 Mavigner M, Raper J, Kovacs-Balint Z, Gumber S, O'Neal JT, Bhaumik SK, Zhang X, Habib J, Mattingly C, McDonald CE, Avanzato V, Burke MW, Magnani DM, Bailey VK, Watkins DI, ... ... Silvestri G, et al. Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques. Science Translational Medicine. 10. PMID 29618564 DOI: 10.1126/Scitranslmed.Aao6975  0.348
2018 Laforge M, Silvestre R, Rodrigues V, Garibal J, Campillo-Gimenez L, Mouhamad S, Monceaux V, Cumont MC, Rabezanahary H, Pruvost A, Cordeiro-da-Silva A, Hurtrel B, Silvestri G, Senik A, Estaquier J. The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques. The Journal of Clinical Investigation. PMID 29553486 DOI: 10.1172/Jci95127  0.623
2018 Carnathan DG, Mackel JJ, Sweat SL, Enemuo CA, Gebru EH, Dhadvai P, Gangadhara S, Hicks S, Vanderford TH, Amara RR, Esparza J, Lu W, Andrieu JM, Silvestri G. Intragastric administration of Lactobacillus plantarum and AT-2-inactivated SIV does not protect Indian rhesus macaques from intra-rectal SIV challenge nor reduce virus replication after transmission. Journal of Virology. PMID 29491157 DOI: 10.1128/Jvi.02030-17  0.552
2018 Klasse PJ, Ketas TJ, Cottrell CA, Ozorowski G, Debnath G, Camara D, Francomano E, Pugach P, Ringe RP, LaBranche CC, van Gils MJ, Bricault CA, Barouch DH, Crotty S, Silvestri G, et al. Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques. Plos Pathogens. 14: e1006913. PMID 29474444 DOI: 10.1371/Journal.Ppat.1006913  0.392
2018 Carnathan D, Lawson B, Yu J, Patel K, Billingsley JM, Tharp GK, Delmas OM, Dawoud R, Wilkinson P, Nicolette C, Cameron MJ, Sekaly RP, Bosinger SE, Silvestri G, Vanderford TH. Reduced chronic lymphocyte activation following Interferon-α blockade in the acute phase of SIV infection in rhesus macaques. Journal of Virology. PMID 29467313 DOI: 10.1128/Jvi.01760-17  0.488
2018 Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M, Silvestri G, Chahroudi A, et al. Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART. Plos Pathogens. 14: e1006871. PMID 29466439 DOI: 10.1371/Journal.Ppat.1006871  0.455
2018 McBrien JB, Kumar NA, Silvestri G. Mechanisms of CD8+ T cell-mediated suppression of HIV/SIV replication. European Journal of Immunology. PMID 29427516 DOI: 10.1002/Eji.201747172  0.669
2018 Palesch D, Bosinger SE, Tharp GK, Vanderford TH, Paiardini M, Chahroudi A, Johnson ZP, Kirchhoff F, Hahn BH, Norgren RB, Patel NB, Sodora DL, Dawoud RA, Stewart CB, Seepo SM, ... ... Silvestri G, et al. Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host. Nature. 553: 77-81. PMID 29300007 DOI: 10.1038/Nature25140  0.44
2018 Silvestri G. D-102 Immune-based interventions for HIV cure: lessons from NHP models Journal of Acquired Immune Deficiency Syndromes. 77: 39. DOI: 10.1097/01.Qai.0000532594.82425.46  0.371
2017 Reiss S, Baxter AE, Cirelli KM, Dan JM, Morou A, Daigneault A, Brassard N, Silvestri G, Routy JP, Havenar-Daughton C, Crotty S, Kaufmann DE. Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells. Plos One. 12: e0186998. PMID 29065175 DOI: 10.1371/Journal.Pone.0186998  0.516
2017 McGary CS, Deleage C, Harper J, Micci L, Ribeiro SP, Paganini S, Kuri-Cervantes L, Benne C, Ryan ES, Balderas R, Jean S, Easley K, Marconi V, Silvestri G, Estes JD, et al. CTLA-4(+)PD-1(-) Memory CD4(+) T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques. Immunity. 47: 776-788.e5. PMID 29045906 DOI: 10.1016/J.Immuni.2017.09.018  0.575
2017 Magnani DM, Rogers TF, Beutler N, Ricciardi MJ, Bailey VK, Gonzalez-Nieto L, Briney B, Sok D, Le K, Strubel A, Gutman MJ, Pedreño-Lopez N, Grubaugh ND, Silveira CGT, Maxwell HS, ... ... Silvestri G, et al. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques. Science Translational Medicine. 9. PMID 28978754 DOI: 10.1126/Scitranslmed.Aan8184  0.381
2017 Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, ... ... Silvestri G, et al. Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches. Immunity. 46: 1073-1088.e6. PMID 28636956 DOI: 10.1016/J.Immuni.2017.05.007  0.393
2017 Nixon CC, Mavigner M, Silvestri G, Garcia JV. In Vivo Models of Human Immunodeficiency Virus Persistence and Cure Strategies. The Journal of Infectious Diseases. 215: S142-S151. PMID 28520967 DOI: 10.1093/Infdis/Jiw637  0.488
2017 McGary CS, Alvarez X, Harrington S, Cervasi B, Ryan ES, Iriele RI, Paganini S, Harper JL, Easley K, Silvestri G, Ansari AA, Lichterfeld M, Micci L, Paiardini M. The loss of CCR6(+) and CD161(+) CD4(+) T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques. Mucosal Immunology. PMID 28051083 DOI: 10.1038/Mi.2016.116  0.61
2017 Kumar NA, McBrien J, Mavinger M, Robinson C, White E, Viviano F, Carnathan D, Chahroudi A, Silvestri G, Vanderford T. CD4+ T-cell activation does not lead to expression of latent infection Journal of Virus Eradication. 3: 4. DOI: 10.1016/S2055-6640(20)30575-6  0.582
2016 Roberts ER, Carnathan DG, Li H, Shaw GM, Silvestri G, Betts MR. Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques. Plos Pathogens. 12: e1006135. PMID 28036372 DOI: 10.1371/Journal.Ppat.1006135  0.64
2016 Havenar-Daughton C, Carnathan DG, Torrents de la Peña A, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL, van der Woude P, Locci M, Le KM, de Taeye SW, Sok D, ... ... Silvestri G, et al. Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer. Cell Reports. 17: 2195-2209. PMID 27880897 DOI: 10.1016/J.Celrep.2016.10.085  0.466
2016 Mavigner M, Lee ST, Habib J, Robinson C, Silvestri G, O'Doherty U, Chahroudi A. Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR. Journal of Virus Eradication. 2: 219-226. PMID 27781104 DOI: 10.1016/S2055-6640(20)30870-0  0.43
2016 Chahroudi A, Silvestri G. What pediatric nonprogressors and natural SIV hosts teach us about HIV. Science Translational Medicine. 8: 358fs16. PMID 27683549 DOI: 10.1126/Scitranslmed.Aaj1874  0.496
2016 Cartwright EK, Spicer L, Smith SA, Lee D, Fast R, Paganini S, Lawson BO, Nega M, Easley K, Schmitz JE, Bosinger SE, Paiardini M, Chahroudi A, Vanderford TH, Estes JD, ... ... Silvestri G, et al. CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy. Immunity. 45: 656-68. PMID 27653601 DOI: 10.1016/J.Immuni.2016.08.018  0.648
2016 Dan JM, Havenar-Daughton C, Silvestri G, Sette A, Crotty S. Response to Comment on "A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood". Journal of Immunology (Baltimore, Md. : 1950). 197: 2558. PMID 27638936 DOI: 10.4049/jimmunol.1601321  0.379
2016 Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, ... ... Silvestri G, et al. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nature Medicine. PMID 27400264 DOI: 10.1038/Nm.4108  0.418
2016 Havenar-Daughton C, Reiss SM, Carnathan DG, Wu JE, Kendric K, Torrents de la Peña A, Kasturi SP, Dan JM, Bothwell M, Sanders RW, Pulendran B, Silvestri G, Crotty S. Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique. Journal of Immunology (Baltimore, Md. : 1950). PMID 27335502 DOI: 10.4049/Jimmunol.1600320  0.511
2016 Rivera-Hernandez T, Pandey M, Henningham A, Cole J, Choudhury B, Cork AJ, Gillen CM, Ghaffar KA, West NP, Silvestri G, Good MF, Moyle PM, Toth I, Nizet V, Batzloff MR, et al. Differing Efficacies of Lead Group A Streptococcal Vaccine Candidates and Full-Length M Protein in Cutaneous and Invasive Disease Models. Mbio. 7. PMID 27302756 DOI: 10.1128/Mbio.00618-16  0.303
2016 Yang ZW, Jiang YH, Ma C, Silvestri G, Bosinger SE, Li BL, Jong A, Zhou YH, Huang SH. Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque. Plos One. 11: e0156170. PMID 27280726 DOI: 10.1371/Journal.Pone.0156170  0.486
2016 Calascibetta F, Micci L, Carnathan D, Lawson B, Vanderford TH, Bosinger SE, Easley K, Chahroudi A, Mackel J, Keele BF, Long S, Lifson J, Paiardini M, Silvestri G. Antiretroviral therapy in SIV-infected sooty mangabeys: implications for AIDS pathogenesis. Journal of Virology. PMID 27279614 DOI: 10.1128/Jvi.00598-16  0.624
2016 Moldt B, Le KM, Carnathan DG, Whitney JB, Schultz N, Lewis MG, Borducchi EN, Smith KM, Mackel JJ, Sweat SL, Hodges AP, Godzik A, Parren PW, Silvestri G, Barouch DH, et al. Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques. Aids (London, England). 30: 1543-1551. PMID 27243773 DOI: 10.1097/Qad.0000000000001102  0.349
2016 Ortiz AM, Carnathan DG, Yu J, Sheehan KM, Kim P, Reynaldi A, Vanderford TH, Klatt NR, Brenchley JM, Davenport MP, Silvestri G. Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys. Plos One. 11: e0156352. PMID 27227993 DOI: 10.1371/Journal.Pone.0156352  0.777
2016 Cartwright EK, Palesch D, Mavigner M, Paiardini M, Chahroudi A, Silvestri G. Initiation of antiretroviral therapy restores CD4+ TSCM homeostasis in SIV-infected macaques. Journal of Virology. PMID 27170752 DOI: 10.1128/Jvi.00492-16  0.596
2016 Kumar N, Chahroudi A, Silvestri G. Animal models to achieve an HIV cure. Current Opinion in Hiv and Aids. PMID 27152962 DOI: 10.1097/Coh.0000000000000290  0.543
2016 Tsai P, Thayer WO, Liu L, Silvestri G, Nordstrom JL, Garcia JV. CD19xCD3 DART protein mediates human B-cell depletion in vivo in humanized BLT mice. Molecular Therapy Oncolytics. 3: 15024. PMID 27119115 DOI: 10.1038/Mto.2015.24  0.451
2016 Jacobson J, Bosinger S, Kang M, Belaunzaran-Zamudio P, Matining RM, Wilson C, Flexner CW, Clagett B, Plants J, Read S, Purdue L, Myers L, Boone L, Tebas P, Kumar P, ... ... Silvestri G, et al. The Effect of Chloroquine on Immune Activation and Interferon Signatures Associated with HIV-1. Aids Research and Human Retroviruses. PMID 26935044 DOI: 10.1089/Aid.2015.0336  0.515
2016 Ploquin MJ, Silvestri G, Müller-Trutwin M. Immune activation in HIV infection: what can the natural hosts of simian immunodeficiency virus teach us? Current Opinion in Hiv and Aids. 11: 201-8. PMID 26845673 DOI: 10.1097/Coh.0000000000000238  0.581
2016 Chahroudi A, Silvestri G. HIV and Tfh Cells: Circulating New Ideas to Identify and Protect. Immunity. 44: 16-8. PMID 26789919 DOI: 10.1016/J.Immuni.2015.12.016  0.53
2016 Mavigner M, Deleage C, Habib J, Rosen E, Kashuba A, Amblard F, Schinazi R, Geleziunas R, Hesselgesser J, Li B, Hattersley J, Mcgary C, Paiardini M, Wood M, Sodora D, ... Silvestri G, et al. Simian Immunodeficiency Virus (SIV) Persistence in Antiretroviral Therapy (ART)-Treated Infant Rhesus Macaques Open Forum Infectious Diseases. 3. DOI: 10.1093/Ofid/Ofw172.09  0.335
2016 Silvestri G, Cartwright EK. HIV and AIDS: Science Wrestles with 10,000 Nucleotides-Points but No Pin Viral Pathogenesis: From Basics to Systems Biology: Third Edition. 107-123. DOI: 10.1016/B978-0-12-800964-2.00009-4  0.352
2015 Rokx C, Richman DD, Müller-Trutwin M, Silvestri G, Lunzen J, Khoo S, Lichterfeld M, Altfeld M, Perno CF, Hunt PW, Mallon P, Rockstroh JK, Pozniak AL, Clotet B, Boucher CA. Second European Round Table on the Future Management of HIV: 10-11 October 2014, Barcelona, Spain. Journal of Virus Eradication. 1: 211-20. PMID 27482415 DOI: 10.1016/S2055-6640(20)30497-0  0.463
2015 Chowdhury A, Del Rio Estrada PM, Tharp GK, Trible RP, Amara RR, Chahroudi A, Reyes-Teran G, Bosinger SE, Silvestri G. Correction: Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (TFH) in Simian Immunodeficiency Virus-Infected Rhesus Macaques May Contribute to Accumulation of TFH in Chronic Infection. Journal of Immunology (Baltimore, Md. : 1950). 195: 5843. PMID 26637665 DOI: 10.4049/jimmunol.1502269  0.464
2015 Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He T, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, ... ... Silvestri G, et al. Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. The Journal of Clinical Investigation. PMID 26551680 DOI: 10.1172/Jci81400  0.533
2015 Chowdhury A, Del Rio PM, Tharp GK, Trible RP, Amara RR, Chahroudi A, Reyes-Teran G, Bosinger SE, Silvestri G. Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (TFH) in Simian Immunodeficiency Virus-Infected Rhesus Macaques May Contribute to Accumulation of TFH in Chronic Infection. Journal of Immunology (Baltimore, Md. : 1950). 195: 3237-47. PMID 26297764 DOI: 10.4049/Jimmunol.1402701  0.636
2015 Burton SL, Kilgore KM, Smith SA, Reddy S, Hunter E, Robinson HL, Silvestri G, Amara RR, Derdeyn CA. Breakthrough of SIV strain smE660 challenge in SIV strain mac239-vaccinated rhesus macaques despite potent autologous neutralizing antibody responses. Proceedings of the National Academy of Sciences of the United States of America. PMID 26261312 DOI: 10.1073/Pnas.1509731112  0.47
2015 Mir KD, Mavigner M, Wang C, Paiardini M, Sodora DL, Chahroudi AM, Bosinger SM, Silvestri G. Reduced SIV replication in macrophages of sooty mangabeys is associated with increased expression of host restriction factors. Journal of Virology. PMID 26202248 DOI: 10.1128/Jvi.00710-15  0.519
2015 Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG. Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV. Journal of Virology. 89: 9252-61. PMID 26109719 DOI: 10.1128/Jvi.01236-15  0.633
2015 Chowdhury A, Hayes TL, Bosinger SE, Lawson BO, Vanderford T, Schmitz JE, Paiardini M, Betts M, Chahroudi A, Estes JD, Silvestri G. Differential impact of in vivo CD8+ T-lymphocyte depletion in controller versus progressor SIV-infected macaques. Journal of Virology. PMID 26063417 DOI: 10.1128/Jvi.00869-15  0.575
2015 Kilgore KM, Murphy MK, Burton SL, Wetzel KS, Smith SA, Xiao P, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Hunter E, et al. Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope. Journal of Virology. 89: 8130-51. PMID 26018167 DOI: 10.1128/Jvi.01221-14  0.407
2015 Mylvaganam GH, Silvestri G, Amara RR. HIV therapeutic vaccines: moving towards a functional cure. Current Opinion in Immunology. 35: 1-8. PMID 25996629 DOI: 10.1016/J.Coi.2015.05.001  0.536
2015 Jochems SP, Jacquelin B, Chauveau L, Huot N, Petitjean G, Lepelley A, Liovat AS, Ploquin MJ, Cartwright EK, Bosinger SE, Silvestri G, Barré-Sinoussi F, Lebon P, Schwartz O, Müller-Trutwin MC. Plasmacytoid Dendritic Cell Infection and Sensing Capacity during Pathogenic and Nonpathogenic Simian Immunodeficiency Virus Infection. Journal of Virology. 89: 6918-27. PMID 25903334 DOI: 10.1128/Jvi.00332-15  0.63
2015 Barbian HJ, Decker JM, Bibollet-Ruche F, Galimidi RP, West AP, Learn GH, Parrish NF, Iyer SS, Li Y, Pace CS, Song R, Huang Y, Denny TN, Mouquet H, Martin L, ... ... Silvestri G, et al. Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas. Mbio. 6. PMID 25900654 DOI: 10.1128/Mbio.00296-15  0.564
2015 Claiborne DT, Prince JL, Scully E, Macharia G, Micci L, Lawson B, Kopycinski J, Deymier MJ, Vanderford TH, Nganou-Makamdop K, Ende Z, Brooks K, Tang J, Yu T, Lakhi S, ... ... Silvestri G, et al. Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression. Proceedings of the National Academy of Sciences of the United States of America. 112: E1480-9. PMID 25730868 DOI: 10.1073/Pnas.1421607112  0.656
2015 Chahroudi A, Silvestri G, Lichterfeld M. T memory stem cells and HIV: a long-term relationship. Current Hiv/Aids Reports. 12: 33-40. PMID 25578055 DOI: 10.1007/S11904-014-0246-4  0.544
2015 Carnathan DG, Wetzel KS, Yu J, Lee ST, Johnson BA, Paiardini M, Yan J, Morrow MP, Sardesai NY, Weiner DB, Ertl HC, Silvestri G. Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America. 112: 518-23. PMID 25550504 DOI: 10.1073/Pnas.1407466112  0.603
2015 Yu H, Khalid M, Heigele A, Schmökel J, Usmani SM, van der Merwe J, Münch J, Silvestri G, Kirchhoff F. Lentiviral Nef proteins manipulate T cells in a subset-specific manner. Journal of Virology. 89: 1986-2001. PMID 25505066 DOI: 10.1128/Jvi.03104-14  0.646
2015 Moniuszko M, Liyanage NP, Doster MN, Parks RW, Grubczak K, Lipinska D, McKinnon K, Brown C, Hirsch V, Vaccari M, Gordon S, Pegu P, Fenizia C, Flisiak R, Grzeszczuk A, ... ... Silvestri G, et al. Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir. Aids Research and Human Retroviruses. 31: 115-26. PMID 24432835 DOI: 10.1089/Aid.2013.0220  0.577
2015 Mavigner M, Habib J, Cartwright E, Lawson B, Paiardini M, Cohen J, Amblard F, Schinazi R, Geleziunas R, Hesselgesser J, Li B, Hattersley J, Silvestri G, Chahroudi A. Pediatric HIV Cure: A Rhesus Macaque Model Open Forum Infectious Diseases. 2. DOI: 10.1093/Ofid/Ofv133.346  0.396
2014 Micci L, Alvarez X, Iriele RI, Ortiz AM, Ryan ES, McGary CS, Deleage C, McAtee BB, He T, Apetrei C, Easley K, Pahwa S, Collman RG, Derdeyn CA, Davenport MP, ... ... Silvestri G, et al. CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells. Plos Pathogens. 10: e1004467. PMID 25356757 DOI: 10.1371/Journal.Ppat.1004467  0.774
2014 d'Ettorre G, Baroncelli S, Micci L, Ceccarelli G, Andreotti M, Sharma P, Fanello G, Fiocca F, Cavallari EN, Giustini N, Mallano A, Galluzzo CM, Vella S, Mastroianni CM, Silvestri G, et al. Reconstitution of intestinal CD4 and Th17 T cells in antiretroviral therapy suppressed HIV-infected subjects: implication for residual immune activation from the results of a clinical trial. Plos One. 9: e109791. PMID 25340778 DOI: 10.1371/Journal.Pone.0109791  0.614
2014 Mavigner M, Watkins B, Lawson B, Lee ST, Chahroudi A, Kean L, Silvestri G. Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplant. Plos Pathogens. 10: e1004406. PMID 25254512 DOI: 10.1371/Journal.Ppat.1004406  0.558
2014 Klatt NR, Bosinger SE, Peck M, Richert-Spuhler LE, Heigele A, Gile JP, Patel N, Taaffe J, Julg B, Camerini D, Torti C, Martin JN, Deeks SG, Sinclair E, Hecht FM, ... ... Silvestri G, et al. Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. Plos Pathogens. 10: e1004345. PMID 25167059 DOI: 10.1371/Journal.Ppat.1004345  0.849
2014 d'Ettorre G, Ceccarelli G, Giustini N, Mastroianni CM, Silvestri G, Vullo V. Taming HIV-related inflammation with physical activity: a matter of timing. Aids Research and Human Retroviruses. 30: 936-44. PMID 25055246 DOI: 10.1089/Aid.2014.0069  0.449
2014 Sandler NG, Bosinger SE, Estes JD, Zhu RT, Tharp GK, Boritz E, Levin D, Wijeyesinghe S, Makamdop KN, del Prete GQ, Hill BJ, Timmer JK, Reiss E, Yarden G, Darko S, ... ... Silvestri G, et al. Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Nature. 511: 601-5. PMID 25043006 DOI: 10.1038/Nature13554  0.598
2014 McGary CS, Silvestri G, Paiardini M. Animal models for viral infection and cell exhaustion. Current Opinion in Hiv and Aids. 9: 492-9. PMID 25023622 DOI: 10.1097/Coh.0000000000000093  0.539
2014 Muyanja E, Ssemaganda A, Ngauv P, Cubas R, Perrin H, Srinivasan D, Canderan G, Lawson B, Kopycinski J, Graham AS, Rowe DK, Smith MJ, Isern S, Michael S, Silvestri G, et al. Immune activation alters cellular and humoral responses to yellow fever 17D vaccine. The Journal of Clinical Investigation. 124: 3147-58. PMID 24911151 DOI: 10.1172/Jci75429  0.348
2014 Cartwright EK, McGary CS, Cervasi B, Micci L, Lawson B, Elliott ST, Collman RG, Bosinger SE, Paiardini M, Vanderford TH, Chahroudi A, Silvestri G. Divergent CD4+ T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infections. Journal of Immunology (Baltimore, Md. : 1950). 192: 4666-73. PMID 24729621 DOI: 10.4049/Jimmunol.1303193  0.593
2014 Chahroudi A, Cartwright E, Lee ST, Mavigner M, Carnathan DG, Lawson B, Carnathan PM, Hashempoor T, Murphy MK, Meeker T, Ehnert S, Souder C, Else JG, Cohen J, Collman RG, ... ... Silvestri G, et al. Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques. Plos Pathogens. 10: e1003958. PMID 24604066 DOI: 10.1371/Journal.Ppat.1003958  0.573
2014 McGary CS, Cervasi B, Chahroudi A, Micci L, Taaffe J, Meeker T, Silvestri G, Davenport MP, Paiardini M. Increased stability and limited proliferation of CD4+ central memory T cells differentiate nonprogressive simian immunodeficiency virus (SIV) infection of sooty mangabeys from progressive SIV infection of rhesus macaques. Journal of Virology. 88: 4533-42. PMID 24501416 DOI: 10.1128/Jvi.03515-13  0.849
2014 Silvestri G. F-104 Non-human primate models for immunological studies of HIV eradication Journal of Acquired Immune Deficiency Syndromes. 67: 64. DOI: 10.1097/01.Qai.0000456110.29311.46  0.364
2014 Silvestri G, Ansari AA. Final Remarks: What Have We Learned from Natural Simian Immunodeficiency Virus Hosts that Can Help HIV-Infected Humans? Natural Hosts of Siv: Implication in Aids. 367-371. DOI: 10.1016/B978-0-12-404734-1.15001-6  0.387
2014 Ansari AA, Silvestri G. Comparative Studies of Natural and Non-natural Hosts of SIV-An Overview Natural Hosts of Siv: Implication in Aids. 1-18. DOI: 10.1016/B978-0-12-404734-1.00001-2  0.347
2014 AnsAri AA, Silvestri G. Natural Hosts of SIV: Implication in AIDS Natural Hosts of Siv: Implication in Aids. 1-385.  0.322
2013 Schmökel J, Li H, Shabir A, Yu H, Geyer M, Silvestri G, Sodora DL, Hahn BH, Kirchhoff F. Link between primate lentiviral coreceptor usage and Nef function. Cell Reports. 5: 997-1009. PMID 24268781 DOI: 10.1016/J.Celrep.2013.10.028  0.582
2013 Francella N, Elliott ST, Yi Y, Gwyn SE, Ortiz AM, Li B, Silvestri G, Paiardini M, Derdeyn CA, Collman RG. Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo. Retrovirology. 10: 133. PMID 24219995 DOI: 10.1186/1742-4690-10-133  0.679
2013 Petravic J, Vanderford TH, Silvestri G, Davenport M. Estimating the contribution of the gut to plasma viral load in early SIV infection. Retrovirology. 10: 105. PMID 24119218 DOI: 10.1186/1742-4690-10-105  0.434
2013 Bosinger SE, Johnson ZP, Folkner KA, Patel N, Hashempour T, Jochems SP, Del Rio Estrada PM, Paiardini M, Lin R, Vanderford TH, Hiscott J, Silvestri G. Intact type I Interferon production and IRF7 function in sooty mangabeys. Plos Pathogens. 9: e1003597. PMID 24009514 DOI: 10.1371/Journal.Ppat.1003597  0.5
2013 Letko M, Silvestri G, Hahn BH, Bibollet-Ruche F, Gokcumen O, Simon V, Ooms M. Vif proteins from diverse primate lentiviral lineages use the same binding site in APOBEC3G. Journal of Virology. 87: 11861-71. PMID 23986590 DOI: 10.1128/Jvi.01944-13  0.337
2013 Chowdhury A, Silvestri G. Host-pathogen interaction in HIV infection. Current Opinion in Immunology. 25: 463-9. PMID 23890585 DOI: 10.1016/J.Coi.2013.07.003  0.604
2013 Pallikkuth S, Micci L, Ende ZS, Iriele RI, Cervasi B, Lawson B, McGary CS, Rogers KA, Else JG, Silvestri G, Easley K, Estes JD, Villinger F, Pahwa S, Paiardini M. Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21. Plos Pathogens. 9: e1003471. PMID 23853592 DOI: 10.1371/Journal.Ppat.1003471  0.504
2013 Sundaravaradan V, Saleem R, Micci L, Gasper MA, Ortiz AM, Else J, Silvestri G, Paiardini M, Aitchison JD, Sodora DL. Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection. Plos Pathogens. 9: e1003441. PMID 23825945 DOI: 10.1371/Journal.Ppat.1003441  0.729
2013 Francella N, Gwyn SE, Yi Y, Li B, Xiao P, Elliott ST, Ortiz AM, Hoxie JA, Paiardini M, Silvestri G, Derdeyn CA, Collman RG. CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo. Journal of Virology. 87: 9719-32. PMID 23824793 DOI: 10.1128/Jvi.01254-13  0.732
2013 Cervasi B, Carnathan DG, Sheehan KM, Micci L, Paiardini M, Kurupati R, Tuyishime S, Zhou XY, Else JG, Ratcliffe SJ, Ertl HC, Silvestri G. Immunological and virological analyses of rhesus macaques immunized with chimpanzee adenoviruses expressing the simian immunodeficiency virus Gag/Tat fusion protein and challenged intrarectally with repeated low doses of SIVmac. Journal of Virology. 87: 9420-30. PMID 23804645 DOI: 10.1128/Jvi.01456-13  0.488
2013 Silvestri G. Embracing the complexity of HIV immunology. Immunological Reviews. 254: 5-9. PMID 23772611 DOI: 10.1111/Imr.12081  0.386
2013 Evans DT, Silvestri G. Nonhuman primate models in AIDS research. Current Opinion in Hiv and Aids. 8: 255-61. PMID 23615116 DOI: 10.1097/Coh.0B013E328361Cee8  0.461
2013 Vaccari M, Keele BF, Bosinger SE, Doster MN, Ma ZM, Pollara J, Hryniewicz A, Ferrari G, Guan Y, Forthal DN, Venzon D, Fenizia C, Morgan T, Montefiori D, Lifson JD, ... ... Silvestri G, et al. Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure. Journal of Virology. 87: 3538-48. PMID 23325681 DOI: 10.1128/Jvi.02863-12  0.414
2013 Marchetti G, Tincati C, Silvestri G. Microbial translocation in the pathogenesis of HIV infection and AIDS. Clinical Microbiology Reviews. 26: 2-18. PMID 23297256 DOI: 10.1128/Cmr.00050-12  0.535
2013 Kurupati R, Tuyishime S, Kossenkov AV, Sazanovich M, Haut LH, Lasaro MO, Ratcliffe SJ, Bosinger SE, Carnathan DG, Lewis M, Showe LC, Silvestri G, Ertl HC. Correlates of relative resistance against low-dose rectal simian immunodeficiency virus challenges in peripheral blood mononuclear cells of vaccinated rhesus macaques. Journal of Leukocyte Biology. 93: 437-48. PMID 23271702 DOI: 10.1189/Jlb.0612287  0.332
2013 Bosinger SE, Jochems SP, Folkner KA, Hayes TL, Klatt NR, Silvestri G. Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239. Journal of Virology. 87: 433-43. PMID 23097439 DOI: 10.1128/Jvi.01746-12  0.609
2013 Tabb B, Morcock DR, Trubey CM, Quiñones OA, Hao XP, Smedley J, Macallister R, Piatak M, Harris LD, Paiardini M, Silvestri G, Brenchley JM, Alvord WG, Lifson JD, Estes JD. Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection. The Journal of Infectious Diseases. 207: 880-92. PMID 23087435 DOI: 10.1093/Infdis/Jis643  0.542
2012 Burton DR, Ahmed R, Barouch DH, Butera ST, Crotty S, Godzik A, Kaufmann DE, McElrath MJ, Nussenzweig MC, Pulendran B, Scanlan CN, Schief WR, Silvestri G, Streeck H, Walker BD, et al. A Blueprint for HIV Vaccine Discovery. Cell Host & Microbe. 12: 396-407. PMID 23084910 DOI: 10.1016/J.Chom.2012.09.008  0.419
2012 Brenchley JM, Vinton C, Tabb B, Hao XP, Connick E, Paiardini M, Lifson JD, Silvestri G, Estes JD. Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections. Blood. 120: 4172-81. PMID 22990012 DOI: 10.1182/Blood-2012-06-437608  0.622
2012 Micci L, Cervasi B, Ende ZS, Iriele RI, Reyes-Aviles E, Vinton C, Else J, Silvestri G, Ansari AA, Villinger F, Pahwa S, Estes JD, Brenchley JM, Paiardini M. Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques. Blood. 120: 3925-35. PMID 22990011 DOI: 10.1182/Blood-2012-04-420240  0.522
2012 Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, Chun TW, Churchill M, Di Mascio M, Katlama C, Lafeuillade A, Landay A, Lederman M, Lewin SR, ... ... Silvestri G, et al. Towards an HIV cure: a global scientific strategy. Nature Reviews. Immunology. 12: 607-14. PMID 22814509 DOI: 10.1038/Nri3262  0.421
2012 Mir KD, Mavigner M, Silvestri G. The myeloid cytokine network in AIDS pathogenesis. Cytokine & Growth Factor Reviews. 23: 223-31. PMID 22748236 DOI: 10.1016/J.Cytogfr.2012.05.009  0.558
2012 Klatt NR, Estes JD, Sun X, Ortiz AM, Barber JS, Harris LD, Cervasi B, Yokomizo LK, Pan L, Vinton CL, Tabb B, Canary LA, Dang Q, Hirsch VM, Alter G, ... ... Silvestri G, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunology. 5: 646-57. PMID 22643849 DOI: 10.1038/Mi.2012.38  0.693
2012 Boliar S, Murphy MK, Tran TC, Carnathan DG, Armstrong WS, Silvestri G, Derdeyn CA. B-lymphocyte dysfunction in chronic HIV-1 infection does not prevent cross-clade neutralization breadth. Journal of Virology. 86: 8031-40. PMID 22623771 DOI: 10.1128/Jvi.00771-12  0.533
2012 Zeng M, Paiardini M, Engram JC, Beilman GJ, Chipman JG, Schacker TW, Silvestri G, Haase AT. Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution. Blood. 120: 1856-67. PMID 22613799 DOI: 10.1182/Blood-2012-03-418624  0.574
2012 Mir KD, Bosinger SE, Gasper M, Ho O, Else JG, Brenchley JM, Kelvin DJ, Silvestri G, Hu SL, Sodora DL. Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys. Journal of Virology. 86: 7605-15. PMID 22553338 DOI: 10.1128/Jvi.06813-11  0.532
2012 Vanderford TH, Slichter C, Rogers KA, Lawson BO, Obaede R, Else J, Villinger F, Bosinger SE, Silvestri G. Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation. Blood. 119: 5750-7. PMID 22550346 DOI: 10.1182/Blood-2012-02-411496  0.559
2012 Dyavar Shetty R, Velu V, Titanji K, Bosinger SE, Freeman GJ, Silvestri G, Amara RR. PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques. The Journal of Clinical Investigation. 122: 1712-6. PMID 22523065 DOI: 10.1172/Jci60612  0.465
2012 Chahroudi A, Silvestri G. IRIS: the unfortunate rainbow of HIV. Blood. 119: 2971-2. PMID 22461468 DOI: 10.1182/Blood-2012-01-403683  0.575
2012 Chahroudi A, Bosinger SE, Vanderford TH, Paiardini M, Silvestri G. Natural SIV hosts: showing AIDS the door. Science (New York, N.Y.). 335: 1188-93. PMID 22403383 DOI: 10.1126/Science.1217550  0.553
2012 Klatt NR, Silvestri G. CD4+ T cells and HIV: A paradoxical Pas de Deux. Science Translational Medicine. 4: 123ps4. PMID 22378922 DOI: 10.1126/Scitranslmed.3003862  0.655
2012 Klatt NR, Silvestri G, Hirsch V. Nonpathogenic simian immunodeficiency virus infections. Cold Spring Harbor Perspectives in Medicine. 2: a007153. PMID 22315718 DOI: 10.1101/Cshperspect.A007153  0.58
2012 Souquiere S, Apetrei C, Chahroudi A, Pandrea I, Silvestri G, Roques P. Reply to "Control of Simian Immunodeficiency Virus SIVmnd-1 RNA Plasma Viremia after Coinfection or Superinfection with SIVmnd-1 in SIVmnd-2-Infected Mandrills and Vice Versa". Journal of Virology. 86: 2387-8. PMID 22282337 DOI: 10.1128/Jvi.06953-11  0.387
2012 Puga I, Cols M, Barra CM, He B, Cassis L, Gentile M, Comerma L, Chorny A, Shan M, Xu W, Magri G, Knowles DM, Tam W, Chiu A, Bussel JB, ... ... Silvestri G, et al. B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen. Nature Immunology. 13: 170-80. PMID 22197976 DOI: 10.1038/Ni.2194  0.36
2012 Bosinger SE, Jacquelin B, Benecke A, Silvestri G, Müller-Trutwin M. Systems biology of natural simian immunodeficiency virus infections. Current Opinion in Hiv and Aids. 7: 71-8. PMID 22134342 DOI: 10.1097/Coh.0B013E32834Dde01  0.462
2012 Elliott ST, Riddick NE, Francella N, Paiardini M, Vanderford TH, Li B, Apetrei C, Sodora DL, Derdeyn CA, Silvestri G, Collman RG. Cloning and analysis of sooty mangabey alternative coreceptors that support simian immunodeficiency virus SIVsmm entry independently of CCR5. Journal of Virology. 86: 898-908. PMID 22090107 DOI: 10.1128/Jvi.06415-11  0.595
2012 Klatt NR, Canary LA, Vanderford TH, Vinton CL, Engram JC, Dunham RM, Cronise HE, Swerczek JM, Lafont BA, Picker LJ, Silvestri G, Brenchley JM. Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques. Journal of Virology. 86: 1203-13. PMID 22090099 DOI: 10.1128/Jvi.06033-11  0.627
2012 Taaffe JE, Bosinger SE, Del Prete GQ, Else JG, Ratcliffe S, Ward CD, Migone T, Paiardini M, Silvestri G. CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques. Journal of Medical Primatology. 41: 24-42. PMID 22077380 DOI: 10.1111/J.1600-0684.2011.00521.X  0.828
2012 Murphy MK, Boliar S, Tran TC, Carnathan DG, Armstrong W, Silvestri G, Derdeyn C. Heterologous neutralization breadth persists despite B-lymphocyte dysfunction in chronic HIV-1 infection Retrovirology. 9: 103. DOI: 10.1186/1742-4690-9-S2-P103  0.418
2012 Silvestri G. Animal models of functional HIV cure Retrovirology. 9: 1-1. DOI: 10.1186/1742-4690-9-S1-I9  0.517
2012 Hsieh J, McGary C, Wu J, Paiardini M, Micci L, Garcia A, Silvestri G, Hossain MS, Waller EK, Galipeau J. A Novel Synthetic GMCSF and IL7 Fusion Cytokine (GIFT7) Leads to T Cell Neogenesis by Reversing Age-Related Thymic Atrophy and Overcoming PD-1-Assocaited CD8 Exhaustion Blood. 120: 3289-3289. DOI: 10.1182/Blood.V120.21.3289.3289  0.5
2012 Silvestri G. 140 Antiviral Immune Responses, Chronic Immune Activation, and Pattern of Infected Cells in AIDS Pathogenesis: A Lesson From Non-Human Primate Models Journal of Acquired Immune Deficiency Syndromes. 59: 58. DOI: 10.1097/01.Qai.0000413759.38374.95  0.435
2012 Pancino G, Silvestri G, Fowke K. Models of Protection Against HIV/SIV Models of Protection Against Hiv/Siv 0.329
2011 Lakhashe SK, Silvestri G, Ruprecht RM. No acquisition: a new ambition for HIV vaccine development? Current Opinion in Virology. 1: 246-53. PMID 22081778 DOI: 10.1016/J.Coviro.2011.07.005  0.388
2011 Ortiz AM, Klatt NR, Li B, Yi Y, Tabb B, Hao XP, Sternberg L, Lawson B, Carnathan PM, Cramer EM, Engram JC, Little DM, Ryzhova E, Gonzalez-Scarano F, Paiardini M, ... ... Silvestri G, et al. Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques. The Journal of Clinical Investigation. 121: 4433-45. PMID 22005304 DOI: 10.1172/Jci46023  0.789
2011 Elemans M, Seich Al Basatena NK, Klatt NR, Gkekas C, Silvestri G, Asquith B. Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo? Plos Computational Biology. 7: e1002200. PMID 21990968 DOI: 10.1371/Journal.Pcbi.1002200  0.587
2011 Apetrei C, Sumpter B, Souquiere S, Chahroudi A, Makuwa M, Reed P, Ribeiro RM, Pandrea I, Roques P, Silvestri G. Immunovirological analyses of chronically simian immunodeficiency virus SIVmnd-1- and SIVmnd-2-infected mandrills (Mandrillus sphinx). Journal of Virology. 85: 13077-87. PMID 21957286 DOI: 10.1128/Jvi.05693-11  0.611
2011 Durudas A, Chen HL, Gasper MA, Sundaravaradan V, Milush JM, Silvestri G, Johnson W, Giavedoni LD, Sodora DL. Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques. Current Hiv Research. 9: 276-88. PMID 21861823 DOI: 10.2174/157016211797635928  0.54
2011 Bosinger SE, Sodora DL, Silvestri G. Generalized immune activation and innate immune responses in simian immunodeficiency virus infection. Current Opinion in Hiv and Aids. 6: 411-8. PMID 21743324 DOI: 10.1097/Coh.0B013E3283499Cf6  0.456
2011 Vinton C, Klatt NR, Harris LD, Briant JA, Sanders-Beer BE, Herbert R, Woodward R, Silvestri G, Pandrea I, Apetrei C, Hirsch VM, Brenchley JM. CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus. Journal of Virology. 85: 8702-8. PMID 21715501 DOI: 10.1128/Jvi.00332-11  0.584
2011 Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz AM, Chahroudi A, Vinton C, Gordon SN, Bosinger SE, Francella N, Hallberg PL, Cramer E, Schlub T, Chan ML, Riddick NE, ... ... Silvestri G, et al. Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression. Nature Medicine. 17: 830-6. PMID 21706028 DOI: 10.1038/Nm.2395  0.744
2011 Kwa S, Kannanganat S, Nigam P, Siddiqui M, Shetty RD, Armstrong W, Ansari A, Bosinger SE, Silvestri G, Amara RR. Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques. Blood. 118: 2763-73. PMID 21693759 DOI: 10.1182/Blood-2011-02-339515  0.542
2011 Vanderford TH, Bleckwehl C, Engram JC, Dunham RM, Klatt NR, Feinberg MB, Garber DA, Betts MR, Silvestri G. Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques. Plos Pathogens. 7: e1002048. PMID 21625590 DOI: 10.1371/Journal.Ppat.1002048  0.489
2011 Rotger M, Dalmau J, Rauch A, McLaren P, Bosinger SE, Martinez R, Sandler NG, Roque A, Liebner J, Battegay M, Bernasconi E, Descombes P, Erkizia I, Fellay J, Hirschel B, ... ... Silvestri G, et al. Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. The Journal of Clinical Investigation. 121: 2391-400. PMID 21555857 DOI: 10.1172/Jci45235  0.599
2011 d'Ettorre G, Paiardini M, Zaffiri L, Andreotti M, Ceccarelli G, Rizza C, Indinnimeo M, Vella S, Mastroianni CM, Silvestri G, Vullo V. HIV persistence in the gut mucosa of HIV-infected subjects undergoing antiretroviral therapy correlates with immune activation and increased levels of LPS. Current Hiv Research. 9: 148-53. PMID 21457131 DOI: 10.2174/157016211795945296  0.592
2011 Chahroudi A, Meeker T, Lawson B, Ratcliffe S, Else J, Silvestri G. Mother-to-infant transmission of simian immunodeficiency virus is rare in sooty mangabeys and is associated with low viremia. Journal of Virology. 85: 5757-63. PMID 21450815 DOI: 10.1128/Jvi.02690-10  0.47
2011 Zeng M, Smith AJ, Wietgrefe SW, Southern PJ, Schacker TW, Reilly CS, Estes JD, Burton GF, Silvestri G, Lifson JD, Carlis JV, Haase AT. Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. The Journal of Clinical Investigation. 121: 998-1008. PMID 21393864 DOI: 10.1172/Jci45157  0.602
2011 Milush JM, Mir KD, Sundaravaradan V, Gordon SN, Engram J, Cano CA, Reeves JD, Anton E, O'Neill E, Butler E, Hancock K, Cole KS, Brenchley JM, Else JG, Silvestri G, et al. Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells. The Journal of Clinical Investigation. 121: 1102-10. PMID 21317533 DOI: 10.1172/Jci44876  0.622
2011 d'Ettorre G, Paiardini M, Ceccarelli G, Silvestri G, Vullo V. HIV-associated immune activation: from bench to bedside. Aids Research and Human Retroviruses. 27: 355-64. PMID 21309730 DOI: 10.1089/Aid.2010.0342  0.555
2011 Lasaro MO, Haut LH, Zhou X, Xiang Z, Zhou D, Li Y, Giles-Davis W, Li H, Engram JC, Dimenna LJ, Bian A, Sazanovich M, Parzych EM, Kurupati R, Small JC, ... ... Silvestri G, et al. Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 417-26. PMID 21081905 DOI: 10.1038/Mt.2010.238  0.481
2011 Silvestri G. 169 SIV Infection of Natural Hosts Journal of Acquired Immune Deficiency Syndromes. 56: 71. DOI: 10.1097/01.Qai.0000397355.61168.F5  0.433
2010 Gordon SN, Cervasi B, Odorizzi P, Silverman R, Aberra F, Ginsberg G, Estes JD, Paiardini M, Frank I, Silvestri G. Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals. Journal of Immunology (Baltimore, Md. : 1950). 185: 5169-79. PMID 20889546 DOI: 10.4049/Jimmunol.1001801  0.642
2010 Riddick NE, Hermann EA, Loftin LM, Elliott ST, Wey WC, Cervasi B, Taaffe J, Engram JC, Li B, Else JG, Li Y, Hahn BH, Derdeyn CA, Sodora DL, Apetrei C, ... ... Silvestri G, et al. A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo. Plos Pathogens. 6: e1001064. PMID 20865163 DOI: 10.1371/Journal.Ppat.1001064  0.821
2010 Kouyos RD, Gordon SN, Staprans SI, Silvestri G, Regoes RR. Similar impact of CD8+ T cell responses on early virus dynamics during SIV infections of rhesus macaques and sooty mangabeys. Plos Computational Biology. 6. PMID 20865048 DOI: 10.1371/Journal.Pcbi.1000901  0.612
2010 Estes JD, Harris LD, Klatt NR, Tabb B, Pittaluga S, Paiardini M, Barclay GR, Smedley J, Pung R, Oliveira KM, Hirsch VM, Silvestri G, Douek DC, Miller CJ, Haase AT, et al. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. Plos Pathogens. 6: e1001052. PMID 20808901 DOI: 10.1371/Journal.Ppat.1001052  0.553
2010 Chahroudi A, Silvestri G. Interleukin-7 in HIV pathogenesis and therapy. European Cytokine Network. 21: 202-7. PMID 20729180 DOI: 10.1684/Ecn.2010.0205  0.586
2010 Brenchley JM, Silvestri G, Douek DC. Nonprogressive and progressive primate immunodeficiency lentivirus infections. Immunity. 32: 737-42. PMID 20620940 DOI: 10.1016/J.Immuni.2010.06.004  0.611
2010 Chan ML, Petravic J, Ortiz AM, Engram J, Paiardini M, Cromer D, Silvestri G, Davenport MP. Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys. Proceedings. Biological Sciences / the Royal Society. 277: 3773-81. PMID 20591864 DOI: 10.1098/Rspb.2010.0972  0.774
2010 Sodora DL, Silvestri G. HIV, mucosal tissues, and T helper 17 cells: where we come from, where we are, and where we go from here. Current Opinion in Hiv and Aids. 5: 111-3. PMID 20543586 DOI: 10.1097/Coh.0B013E328335C18F  0.48
2010 Harris LD, Tabb B, Sodora DL, Paiardini M, Klatt NR, Douek DC, Silvestri G, Müller-Trutwin M, Vasile-Pandrea I, Apetrei C, Hirsch V, Lifson J, Brenchley JM, Estes JD. Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques. Journal of Virology. 84: 7886-91. PMID 20484518 DOI: 10.1128/Jvi.02612-09  0.449
2010 Engram JC, Cervasi B, Borghans JA, Klatt NR, Gordon SN, Chahroudi A, Else JG, Mittler RS, Sodora DL, de Boer RJ, Brenchley JM, Silvestri G, Paiardini M. Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates. Blood. 116: 748-58. PMID 20484087 DOI: 10.1182/Blood-2010-01-263814  0.551
2010 Li B, Stefano-Cole K, Kuhrt DM, Gordon SN, Else JG, Mulenga J, Allen S, Sodora DL, Silvestri G, Derdeyn CA. Nonpathogenic simian immunodeficiency virus infection of sooty mangabeys is not associated with high levels of autologous neutralizing antibodies. Journal of Virology. 84: 6248-53. PMID 20375163 DOI: 10.1128/Jvi.00295-10  0.572
2010 Costantini A, Giuliodoro S, Butini L, Silvestri G, Leoni P, Montroni M. HIV-induced abnormalities in myelopoiesis and their recovery following antiretroviral therapy. Current Hiv Research. 8: 336-9. PMID 20353391 DOI: 10.2174/157016210791208604  0.57
2010 Taaffe J, Chahroudi A, Engram J, Sumpter B, Meeker T, Ratcliffe S, Paiardini M, Else J, Silvestri G. A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activation. Journal of Virology. 84: 5476-84. PMID 20335252 DOI: 10.1128/Jvi.00039-10  0.854
2010 Klatt NR, Shudo E, Ortiz AM, Engram JC, Paiardini M, Lawson B, Miller MD, Else J, Pandrea I, Estes JD, Apetrei C, Schmitz JE, Ribeiro RM, Perelson AS, Silvestri G. CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. Plos Pathogens. 6: e1000747. PMID 20126441 DOI: 10.1371/Journal.Ppat.1000747  0.761
2010 Vanderford TH, Adamski J, Silvestri G. HIV-associated chronic immune activation: Current understandings and therapeutic intervention Hiv Therapy. 4: 161-177. DOI: 10.2217/Hiv.10.2  0.522
2009 Bosinger SE, Li Q, Gordon SN, Klatt NR, Duan L, Xu L, Francella N, Sidahmed A, Smith AJ, Cramer EM, Zeng M, Masopust D, Carlis JV, Ran L, Vanderford TH, ... ... Silvestri G, et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. The Journal of Clinical Investigation. 119: 3556-72. PMID 19959874 DOI: 10.1172/Jci40115  0.476
2009 Jacquelin B, Mayau V, Targat B, Liovat AS, Kunkel D, Petitjean G, Dillies MA, Roques P, Butor C, Silvestri G, Giavedoni LD, Lebon P, Barré-Sinoussi F, Benecke A, Müller-Trutwin MC. Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response Journal of Clinical Investigation. 119: 3544-3555. PMID 19959873 DOI: 10.1172/Jci40093  0.55
2009 Shedlock DJ, Silvestri G, Weiner DB. Monkeying around with HIV vaccines: using rhesus macaques to define 'gatekeepers' for clinical trials. Nature Reviews. Immunology. 9: 717-28. PMID 19859066 DOI: 10.1038/Nri2636  0.392
2009 Durudas A, Milush JM, Chen HL, Engram JC, Silvestri G, Sodora DL. Elevated levels of innate immune modulators in lymph nodes and blood are associated with more-rapid disease progression in simian immunodeficiency virus-infected monkeys. Journal of Virology. 83: 12229-40. PMID 19759147 DOI: 10.1128/Jvi.01311-09  0.466
2009 Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, Else JG, Estes JD, Hahn BH, Hirsch VM, Kaur A, Kirchhoff F, Muller-Trutwin M, Pandrea I, Schmitz JE, Silvestri G. Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nature Medicine. 15: 861-5. PMID 19661993 DOI: 10.1038/Nm.2013  0.527
2009 Paiardini M, Pandrea I, Apetrei C, Silvestri G. Lessons learned from the natural hosts of HIV-related viruses. Annual Review of Medicine. 60: 485-95. PMID 19630581 DOI: 10.1146/Annurev.Med.60.041807.123753  0.585
2009 Keele BF, Jones JH, Terio KA, Estes JD, Rudicell RS, Wilson ML, Li Y, Learn GH, Beasley TM, Schumacher-Stankey J, Wroblewski E, Mosser A, Raphael J, Kamenya S, Lonsdorf EV, ... ... Silvestri G, et al. Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz. Nature. 460: 515-9. PMID 19626114 DOI: 10.1038/Nature08200  0.601
2009 Costantini A, Giuliodoro S, Butini L, Silvestri G, Leoni P, Montroni M. Abnormalities of erythropoiesis during HIV-1 disease: a longitudinal analysis. Journal of Acquired Immune Deficiency Syndromes (1999). 52: 70-4. PMID 19574926 DOI: 10.1097/Qai.0B013E3181Af65C5  0.449
2009 Engram JC, Dunham RM, Makedonas G, Vanderford TH, Sumpter B, Klatt NR, Ratcliffe SJ, Garg S, Paiardini M, McQuoid M, Altman JD, Staprans SI, Betts MR, Garber DA, Feinberg MB, ... Silvestri G, et al. Vaccine-induced, simian immunodeficiency virus-specific CD8+ T cells reduce virus replication but do not protect from simian immunodeficiency virus disease progression. Journal of Immunology (Baltimore, Md. : 1950). 183: 706-17. PMID 19542473 DOI: 10.4049/Jimmunol.0803746  0.55
2009 Lay MD, Petravic J, Gordon SN, Engram J, Silvestri G, Davenport MP. Is the gut the major source of virus in early simian immunodeficiency virus infection? Journal of Virology. 83: 7517-23. PMID 19458001 DOI: 10.1128/Jvi.00552-09  0.643
2009 Tatsis N, Lasaro MO, Lin SW, Haut LH, Xiang ZQ, Zhou D, Dimenna L, Li H, Bian A, Abdulla S, Li Y, Giles-Davis W, Engram J, Ratcliffe SJ, Silvestri G, et al. Adenovirus vector-induced immune responses in nonhuman primates: responses to prime boost regimens. Journal of Immunology (Baltimore, Md. : 1950). 182: 6587-99. PMID 19414814 DOI: 10.4049/Jimmunol.0900317  0.438
2009 Sereti I, Dunham RM, Spritzler J, Aga E, Proschan MA, Medvik K, Battaglia CA, Landay AL, Pahwa S, Fischl MA, Asmuth DM, Tenorio AR, Altman JD, Fox L, Moir S, ... ... Silvestri G, et al. IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood. 113: 6304-14. PMID 19380868 DOI: 10.1182/Blood-2008-10-186601  0.579
2009 Ortiz AM, Silvestri G. Immunopathogenesis of AIDS. Current Infectious Disease Reports. 11: 239-45. PMID 19366567 DOI: 10.1007/S11908-009-0035-1  0.687
2009 Schmökel J, Li H, Bailes E, Schindler M, Silvestri G, Hahn BH, Apetrei C, Kirchhoff F. Conservation of Nef function across highly diverse lineages of SIVsmm. Retrovirology. 6: 36. PMID 19358735 DOI: 10.1186/1742-4690-6-36  0.505
2009 Giri MS, Nebozyhn M, Raymond A, Gekonge B, Hancock A, Creer S, Nicols C, Yousef M, Foulkes AS, Mounzer K, Shull J, Silvestri G, Kostman J, Collman RG, Showe L, et al. Circulating monocytes in HIV-1-infected viremic subjects exhibit an antiapoptosis gene signature and virus- and host-mediated apoptosis resistance. Journal of Immunology (Baltimore, Md. : 1950). 182: 4459-70. PMID 19299747 DOI: 10.4049/Jimmunol.0801450  0.569
2009 Pandrea I, Silvestri G, Apetrei C. AIDS in african nonhuman primate hosts of SIVs: a new paradigm of SIV infection. Current Hiv Research. 7: 57-72. PMID 19149555 DOI: 10.2174/157016209787048456  0.58
2009 Silvestri G. Immunity in natural SIV infections Journal of Internal Medicine. 265: 97-109. PMID 19093963 DOI: 10.1111/j.1365-2796.2008.02049.x  0.461
2009 Velu V, Titanji K, Zhu B, Husain S, Pladevega A, Lai L, Vanderford TH, Chennareddi L, Silvestri G, Freeman GJ, Ahmed R, Amara RR. Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature. 458: 206-10. PMID 19078956 DOI: 10.1038/Nature07662  0.509
2009 Paiardini M, Hoffman J, Cervasi B, Ortiz AM, Stroud F, Silvestri G, Wilson ME. T-cell phenotypic and functional changes associated with social subordination and gene polymorphisms in the serotonin reuptake transporter in female rhesus monkeys. Brain, Behavior, and Immunity. 23: 286-93. PMID 18992804 DOI: 10.1016/J.Bbi.2008.10.006  0.619
2009 Paiardini M, Cervasi B, Engram JC, Gordon SN, Klatt NR, Muthukumar A, Else J, Mittler RS, Staprans SI, Sodora DL, Silvestri G. Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis. Blood. 113: 612-21. PMID 18832134 DOI: 10.1182/Blood-2008-06-159442  0.572
2009 Mir K, Milush J, Brenchley J, Reeves J, Gordon S, Else J, O'Neill E, Silvestri G, Sodora D. P03-09. Preserved adaptive immune responses and limited immune activation in CD4-low SIV-positive sooty mangabeys Retrovirology. 6: 26. DOI: 10.1186/1742-4690-6-S3-P26  0.321
2009 Harris LD, Estes JD, Klatt NR, Taft B, Barclay R, Douek DC, Silvestri G, Liffson J, Brenchley J. P11-01. Extensive intestinal damage underlies microbial translocation in the GI tract of chronically SIV-infected Rhesus macaques Retrovirology. 6. DOI: 10.1186/1742-4690-6-S3-P146  0.351
2008 Silvestri G. AIDS pathogenesis: A tale of two monkeys Journal of Medical Primatology. 37: 6-12. PMID 19187426 DOI: 10.1111/J.1600-0684.2008.00328.X  0.521
2008 Muthumani K, Choo AY, Shedlock DJ, Laddy DJ, Sundaram SG, Hirao L, Wu L, Thieu KP, Chung CW, Lankaraman KM, Tebas P, Silvestri G, Weiner DB. Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism. Journal of Virology. 82: 11536-44. PMID 18799583 DOI: 10.1128/Jvi.00485-08  0.488
2008 Richardson MW, Carroll RG, Stremlau M, Korokhov N, Humeau LM, Silvestri G, Sodroski J, Riley JL. Mode of transmission affects the sensitivity of human immunodeficiency virus type 1 to restriction by rhesus TRIM5alpha. Journal of Virology. 82: 11117-28. PMID 18768965 DOI: 10.1128/Jvi.01046-08  0.592
2008 Pandrea I, Sodora DL, Silvestri G, Apetrei C. Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts. Trends in Immunology. 29: 419-28. PMID 18676179 DOI: 10.1016/J.It.2008.05.004  0.629
2008 Brenchley JM, Paiardini M, Knox KS, Asher AI, Cervasi B, Asher TE, Scheinberg P, Price DA, Hage CA, Kholi LM, Khoruts A, Frank I, Else J, Schacker T, Silvestri G, et al. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood. 112: 2826-35. PMID 18664624 DOI: 10.1182/Blood-2008-05-159301  0.615
2008 Schindler M, Schmökel J, Specht A, Li H, Münch J, Khalid M, Sodora DL, Hahn BH, Silvestri G, Kirchhoff F. Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection. Plos Pathogens. 4: e1000107. PMID 18636106 DOI: 10.1371/Journal.Ppat.1000107  0.595
2008 Klatt NR, Villinger F, Bostik P, Gordon SN, Pereira L, Engram JC, Mayne A, Dunham RM, Lawson B, Ratcliffe SJ, Sodora DL, Else J, Reimann K, Staprans SI, Haase AT, ... ... Silvestri G, et al. Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys Journal of Clinical Investigation. 118: 2039-2049. PMID 18497876 DOI: 10.1172/Jci33814  0.624
2008 Estes JD, Gordon SN, Zeng M, Chahroudi AM, Dunham RM, Staprans SI, Reilly CS, Silvestri G, Haase AT. Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques. Journal of Immunology (Baltimore, Md. : 1950). 180: 6798-807. PMID 18453600 DOI: 10.4049/Jimmunol.180.10.6798  0.489
2008 Kirchhoff F, Silvestri G. Is Nef the elusive cause of HIV-associated hematopoietic dysfunction? The Journal of Clinical Investigation. 118: 1622-5. PMID 18431512 DOI: 10.1172/Jci35487  0.518
2008 Dunham RM, Cervasi B, Brenchley JM, Albrecht H, Weintrob A, Sumpter B, Engram J, Gordon S, Klatt NR, Frank I, Sodora DL, Douek DC, Paiardini M, Silvestri G. CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. Journal of Immunology (Baltimore, Md. : 1950). 180: 5582-92. PMID 18390743 DOI: 10.4049/Jimmunol.180.8.5582  0.578
2008 Paiardini M, Frank I, Pandrea I, Apetrei C, Silvestri G. Mucosal immune dysfunction in AIDS pathogenesis. Aids Reviews. 10: 36-46. PMID 18385779  0.571
2008 Pandrea I, Onanga R, Souquiere S, Mouinga-Ondéme A, Bourry O, Makuwa M, Rouquet P, Silvestri G, Simon F, Roques P, Apetrei C. Paucity of CD4+ CCR5+ T cells may prevent transmission of simian immunodeficiency virus in natural nonhuman primate hosts by breast-feeding. Journal of Virology. 82: 5501-9. PMID 18385229 DOI: 10.1128/Jvi.02555-07  0.497
2008 Sodora DL, Silvestri G. Immune activation and AIDS pathogenesis Aids. 22: 439-446. PMID 18301056 DOI: 10.1097/Qad.0B013E3282F2Dbe7  0.32
2008 Pandrea I, Ribeiro RM, Gautam R, Gaufin T, Pattison M, Barnes M, Monjure C, Stoulig C, Dufour J, Cyprian W, Silvestri G, Miller MD, Perelson AS, Apetrei C. Simian immunodeficiency virus SIVagm dynamics in African green monkeys. Journal of Virology. 82: 3713-24. PMID 18216122 DOI: 10.1128/Jvi.02402-07  0.592
2008 Gordon SN, Dunham RM, Engram JC, Estes J, Wang Z, Klatt NR, Paiardini M, Pandrea IV, Apetrei C, Sodora DL, Lee HY, Haase AT, Miller MD, Kaur A, Staprans SI, ... ... Silvestri G, et al. Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis. Journal of Virology. 82: 3725-35. PMID 18216113 DOI: 10.1128/Jvi.02408-07  0.619
2008 Kosub DA, Lehrman G, Milush JM, Zhou D, Chacko E, Leone A, Gordon S, Silvestri G, Else JG, Keiser P, Jain MK, Sodora DL. Gamma/Delta T-cell functional responses differ after pathogenic human immunodeficiency virus and nonpathogenic simian immunodeficiency virus infections. Journal of Virology. 82: 1155-65. PMID 18045946 DOI: 10.1128/Jvi.01275-07  0.618
2008 Cumont MC, Diop O, Vaslin B, Elbim C, Viollet L, Monceaux V, Lay S, Silvestri G, Le Grand R, Müller-Trutwin M, Hurtrel B, Estaquier J. Early divergence in lymphoid tissue apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates. Journal of Virology. 82: 1175-84. PMID 18032487 DOI: 10.1128/Jvi.00450-07  0.542
2007 Silvestri G, Paiardini M, Pandrea I, Lederman MM, Sodora DL. Understanding the benign nature of SIV infection in natural hosts. The Journal of Clinical Investigation. 117: 3148-54. PMID 17975656 DOI: 10.1172/Jci33034  0.64
2007 Monceaux V, Viollet L, Petit F, Cumont MC, Kaufmann GR, Aubertin AM, Hurtrel B, Silvestri G, Estaquier J. CD4+ CCR5+ T-Cell Dynamics during Simian Immunodeficiency Virus Infection of Chinese Rhesus Macaques Journal of Virology. 81: 13865-13875. PMID 17898067 DOI: 10.1128/Jvi.00452-07  0.642
2007 Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, et al. Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host. Journal of Immunology (Baltimore, Md. : 1950). 179: 3047-56. PMID 17709519 DOI: 10.4049/Jimmunol.179.5.3047  0.67
2007 Pandrea IV, Gautam R, Ribeiro RM, Brenchley JM, Butler IF, Pattison M, Rasmussen T, Marx PA, Silvestri G, Lackner AA, Perelson AS, Douek DC, Veazey RS, Apetrei C. Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence. Journal of Immunology (Baltimore, Md. : 1950). 179: 3035-46. PMID 17709518 DOI: 10.4049/Jimmunol.179.5.3035  0.635
2007 Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, ... ... Silvestri G, et al. Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. Journal of Immunology (Baltimore, Md. : 1950). 179: 3026-34. PMID 17709517 DOI: 10.4049/Jimmunol.179.5.3026  0.677
2007 Barry AP, Silvestri G, Safrit JT, Sumpter B, Kozyr N, McClure HM, Staprans SI, Feinberg MB. Depletion of CD8+ cells in sooty mangabey monkeys naturally infected with simian immunodeficiency virus reveals limited role for immune control of virus replication in a natural host species. Journal of Immunology (Baltimore, Md. : 1950). 178: 8002-12. PMID 17548637 DOI: 10.4049/Jimmunol.178.12.8002  0.643
2007 Apetrei C, Gautam R, Sumpter B, Carter AC, Gaufin T, Staprans SI, Else J, Barnes M, Cao R, Garg S, Milush JM, Sodora DL, Pandrea I, Silvestri G. Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeys. Journal of Virology. 81: 7913-23. PMID 17507488 DOI: 10.1128/Jvi.00281-07  0.615
2007 Gautam R, Carter AC, Katz N, Butler IF, Barnes M, Hasegawa A, Ratterree M, Silvestri G, Marx PA, Hirsch VM, Pandrea I, Apetrei C. In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaques. Virology. 362: 257-70. PMID 17303205 DOI: 10.1016/J.Virol.2006.12.037  0.457
2007 Sumpter B, Dunham R, Gordon S, Engram J, Hennessy M, Kinter A, Paiardini M, Cervasi B, Klatt N, McClure H, Milush JM, Staprans S, Sodora DL, Silvestri G. Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis. Journal of Immunology (Baltimore, Md. : 1950). 178: 1680-91. PMID 17237418 DOI: 10.4049/Jimmunol.178.3.1680  0.647
2007 Pandrea I, Apetrei C, Gordon S, Barbercheck J, Dufour J, Bohm R, Sumpter B, Roques P, Marx PA, Hirsch VM, Kaur A, Lackner AA, Veazey RS, Silvestri G. Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts. Blood. 109: 1069-76. PMID 17003371 DOI: 10.1182/Blood-2006-05-024364  0.605
2006 Magnani M, Paiardini M, Cervasi B, Serafini S, Fraternale A, Silvestri G. Fludarabine delivery by autologous red blood cells induces macrophage depletion in chronically SIV-infected Sooty Mangabeys. Journal of Controlled Release : Official Journal of the Controlled Release Society. 116: e45-47. PMID 17718963 DOI: 10.1016/J.Jconrel.2006.09.042  0.415
2006 Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Medicine. 12: 1365-71. PMID 17115046 DOI: 10.1038/Nm1511  0.535
2006 Cervasi B, Paiardini M, Serafini S, Fraternale A, Menotta M, Engram J, Lawson B, Staprans SI, Piedimonte G, Perno CF, Silvestri G, Magnani M. Administration of fludarabine-loaded autologous red blood cells in simian immunodeficiency virus-infected sooty mangabeys depletes pSTAT-1-expressing macrophages and delays the rebound of viremia after suspension of antiretroviral therapy. Journal of Virology. 80: 10335-45. PMID 17041214 DOI: 10.1128/Jvi.00472-06  0.533
2006 Costantini A, Giuliodoro S, Mancini S, Butini L, Regnery CM, Silvestri G, Greco F, Leoni P, Montroni M. Impaired in-vitro growth of megakaryocytic colonies derived from CD34 cells of HIV-1-infected patients with active viral replication. Aids. 20: 1713-1720. PMID 16931935 DOI: 10.1097/01.Aids.0000242817.88086.8C  0.588
2006 Pandrea I, Silvestri G, Onanga R, Veazey RS, Marx PA, Hirsch V, Apetrei C. Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: common patterns and species-specific differences. Journal of Medical Primatology. 35: 194-201. PMID 16872282 DOI: 10.1111/J.1600-0684.2006.00168.X  0.43
2006 Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell. 125: 1055-67. PMID 16777597 DOI: 10.1016/J.Cell.2006.04.033  0.63
2006 Dunham R, Pagliardini P, Gordon S, Sumpter B, Engram J, Moanna A, Paiardini M, Mandl JN, Lawson B, Garg S, McClure HM, Xu YX, Ibegbu C, Easley K, Katz N, ... ... Silvestri G, et al. The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus. Blood. 108: 209-17. PMID 16522814 DOI: 10.1182/Blood-2005-12-4897  0.624
2006 Paiardini M, Cervasi B, Sumpter B, McClure HM, Sodora DL, Magnani M, Staprans SI, Piedimonte G, Silvestri G. Perturbations of cell cycle control in T cells contribute to the different outcomes of simian immunodeficiency virus infection in rhesus macaques and sooty mangabeys. Journal of Virology. 80: 634-42. PMID 16378966 DOI: 10.1128/Jvi.80.2.634-642.2006  0.602
2006 Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Sharp P, Silvestri G, et al. Retrovirology. 3: S95. DOI: 10.1186/1742-4690-3-S1-S95  0.662
2006 Silvestri G. Understanding the benign nature of natural SIV infection: Implications for AIDS pathogenesis Retrovirology. 3: 1-1. DOI: 10.1186/1742-4690-3-S1-S94  0.563
2006 Staprans S, Klucking S, Silvestri G, Chavan R, Barry A, Feinberg M. Retrovirology. 3: S47. DOI: 10.1186/1742-4690-3-S1-S47  0.62
2005 Silvestri G. Naturally SIV-infected sooty mangabeys: Are we closer to understanding why they do not develop AIDS? Journal of Medical Primatology. 34: 243-252. PMID 16128919 DOI: 10.1111/J.1600-0684.2005.00122.X  0.579
2005 Muthukumar A, Zhou D, Paiardini M, Barry AP, Cole KS, McClure HM, Staprans SI, Silvestri G, Sodora DL. Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys. Blood. 106: 3839-45. PMID 16105985 DOI: 10.1182/Blood-2005-01-0394  0.581
2005 Moanna A, Dunham R, Paiardini M, Silvestri G. CD4+ T-cell depletion in HIV infection: killed by friendly fire? Current Hiv/Aids Reports. 2: 16-23. PMID 16091244 DOI: 10.1007/S11904-996-0004-3  0.653
2005 Chahroudi A, Chavan R, Kozyr N, Koyzr N, Waller EK, Silvestri G, Feinberg MB. Vaccinia virus tropism for primary hematolymphoid cells is determined by restricted expression of a unique virus receptor. Journal of Virology. 79: 10397-407. PMID 16051832 DOI: 10.1128/Jvi.79.16.10397-10407.2005  0.545
2005 Miller JD, Masopust D, Wherry EJ, Kaech S, Silvestri G, Ahmed R. Differentiation of CD8 T cells in response to acute and chronic viral infections: Implications for HIV vaccine development Current Drug Targets - Infectious Disorders. 5: 121-129. PMID 15975018 DOI: 10.2174/1568005054201544  0.621
2005 Derdeyn CA, Silvestri G. Viral and host factors in the pathogenesis of HIV infection Current Opinion in Immunology. 17: 366-373. PMID 15955686 DOI: 10.1016/J.Coi.2005.06.001  0.65
2005 Hurtrel B, Petit F, Arnoult D, Müller-Trutwin M, Silvestri G, Estaquier J. Apoptosis in SIV infection Cell Death & Differentiation. 12: 979-990. PMID 15818408 DOI: 10.1038/Sj.Cdd.4401600  0.592
2005 Silvestri G, Fedanov A, Germon S, Kozyr N, Kaiser WJ, Garber DA, McClure H, Feinberg MB, Staprans SI. Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hosts. Journal of Virology. 79: 4043-54. PMID 15767406 DOI: 10.1128/Jvi.79.7.4043-4054.2005  0.573
2005 Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, Gordon S, Radziewicz H, Piedimonte G, Magnani M, Montroni M, Kaech SM, Weintrob A, Altman JD, Sodora DL, Feinberg MB, ... Silvestri G, et al. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals. Journal of Immunology (Baltimore, Md. : 1950). 174: 2900-9. PMID 15728501 DOI: 10.4049/Jimmunol.174.5.2900  0.646
2004 Staprans SI, Barry AP, Silvestri G, Safrit JT, Kozyr N, Sumpter B, Nguyen H, McClure H, Montefiori D, Cohen JI, Feinberg MB. Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein. Proceedings of the National Academy of Sciences of the United States of America. 101: 13026-31. PMID 15326293 DOI: 10.1073/Pnas.0404739101  0.61
2004 Garber DA, Silvestri G, Feinberg MB. Prospects for an AIDS vaccine: Three big questions, no easy answers Lancet Infectious Diseases. 4: 397-413. PMID 15219551 DOI: 10.1016/S1473-3099(04)01056-4  0.39
2004 Paiardini M, Cervasi B, Dunham R, Sumpter B, Radziewicz H, Silvestri G. Cell-cycle dysregulation in the immunopathogenesis of AIDS. Immunologic Research. 29: 253-68. PMID 15181287 DOI: 10.1385/Ir:29:1-3:253  0.648
2004 Paiardini M, Cervasi B, Galati D, Dominici S, Albrecht H, Sfacteria A, Magnani M, Silvestri G, Piedimonte G. Early correction of cell cycle perturbations predicts the immunological response to therapy in HIV-infected patients. Aids (London, England). 18: 393-402. PMID 15090790 DOI: 10.1097/00002030-200402200-00004  0.485
2004 Regoes RR, Antia R, Garber DA, Silvestri G, Feinberg MB, Staprans SI. Roles of Target Cells and Virus-Specific Cellular Immunity in Primary Simian Immunodeficiency Virus Infection Journal of Virology. 78: 4866-4875. PMID 15078967 DOI: 10.1128/Jvi.78.9.4866-4875.2004  0.535
2004 Garber DA, Silvestri G, Barry AP, Fedanov A, Kozyr N, McClure H, Montefiori DC, Larsen CP, Altman JD, Staprans SI, Feinberg MB. Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication. The Journal of Clinical Investigation. 113: 836-45. PMID 15067316 DOI: 10.1172/Jci19442  0.601
2004 Muthukumar A, Wozniakowski A, Gauduin MC, Paiardini M, McClure HM, Johnson RP, Silvestri G, Sodora DL. Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus-induced disease progression. Blood. 103: 973-9. PMID 14525780 DOI: 10.1182/Blood-2003-03-0874  0.498
2003 Galati D, Paiardini M, Cervasi B, Albrecht H, Bocchino M, Costantini A, Montroni M, Magnani M, Piedimonte G, Silvestri G. Specific changes in the posttranslational regulation of nucleolin in lymphocytes from patients infected with human immunodeficiency virus. The Journal of Infectious Diseases. 188: 1483-91. PMID 14624373 DOI: 10.1086/379249  0.494
2003 Silvestri G, Feinberg MB. Turnover of lymphocytes and conceptual paradigms in HIV infection Journal of Clinical Investigation. 112: 821-824. PMID 12975464 DOI: 10.1172/Jci19799  0.606
2003 Chahroudi A, Silvestri G, Feinberg MB. Measuring T cell-mediated cytotoxicity using fluorogenic caspase substrates. Methods (San Diego, Calif.). 31: 120-6. PMID 12957569 DOI: 10.1016/S1046-2023(03)00121-X  0.399
2003 Costantini A, Mancini S, Giuliodoro S, Butini L, Regnery CM, Silvestri G, Montroni M. Effects of cryopreservation on lymphocyte immunophenotype and function Journal of Immunological Methods. 278: 145-155. PMID 12957403 DOI: 10.1016/S0022-1759(03)00202-3  0.569
2003 Silvestri G, Sodora DL, Koup RA, Paiardini M, O'Neil SP, McClure HM, Staprans SI, Feinberg MB. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity. 18: 441-52. PMID 12648460 DOI: 10.1016/S1074-7613(03)00060-8  0.637
2002 Galati D, Bocchino M, Paiardini M, Cervasi B, Silvestri G, Piedimonte G. Cell cycle dysregulation during HIV infection: perspectives of a target based therapy. Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 2: 53-61. PMID 12477296  0.525
2002 Fraternale A, Casabianca A, Orlandi C, Chiarantini L, Brandi G, Silvestri G, Magnani M. Repeated cycles of alternate administration of fludarabine and Zidovudine plus Didanosine inhibits murine AIDS and reduces proviral DNA content in lymph nodes to undetectable levels. Virology. 302: 354-362. PMID 12441079 DOI: 10.1006/Viro.2002.1649  0.395
2002 Feinberg MB, Silvestri G. TS cells and immune tolerance induction: A regulatory renaissance? Nature Immunology. 3: 215-217. PMID 11875459 DOI: 10.1038/Ni0302-215  0.473
2002 Liu L, Chahroudi A, Silvestri G, Wernett ME, Kaiser WJ, Safrit JT, Komoriya A, Altman JD, Packard BZ, Feinberg MB. Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates. Nature Medicine. 8: 185-9. PMID 11821904 DOI: 10.1038/Nm0202-185  0.38
2001 Paiardini M, Galati D, Cervasi B, Cannavo G, Galluzzi L, Montroni M, Guetard D, Magnani M, Piedimonte G, Silvestri G. Exogenous interleukin-2 administration corrects the cell cycle perturbation of lymphocytes from human immunodeficiency virus-infected individuals. Journal of Virology. 75: 10843-55. PMID 11602725 DOI: 10.1128/Jvi.75.22.10843-10855.2001  0.493
2001 Munoz-Calleja C, Costantini A, Silvestri G, Butini L, Regnery CM, Mancini S, Montroni M. Highly active antiretroviral therapy induces specific changes in effector and central memory T cell sub-populations. Aids. 15: 1887-1890. PMID 11579255 DOI: 10.1097/00002030-200109280-00022  0.58
2001 Cannavo' G, Paiardini M, Galati D, Cervasi B, Montroni M, De Vico G, Guetard D, Bocchino ML, Picerno I, Magnani M, Silvestri G, Piedimonte G. Abnormal intracellular kinetics of cell-cycle-dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: a novel biologic link between immune activation, accelerated T-cell turnover, and high levels of apoptosis. Blood. 97: 1756-64. PMID 11238118 DOI: 10.1182/Blood.V97.6.1756  0.601
2000 Sodora DL, Douek DC, Silvestri G, Montgomery L, Rosenzweig M, Igarashi T, Bernacky B, Johnson RP, Feinberg MB, Martin MA, Koup RA. Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys. European Journal of Immunology. 30: 1145-53. PMID 10760804 DOI: 10.1002/(Sici)1521-4141(200004)30:4<1145::Aid-Immu1145>3.0.Co;2-7  0.476
1999 Piedimonte G, Corsi D, Paiardini M, Cannavò G, Ientile R, Picerno I, Montroni M, Silvestri G, Magnani M. Unscheduled cyclin B expression and p34 cdc2 activation in T lymphocytes from HIV-infected patients. Aids (London, England). 13: 1159-64. PMID 10416518 DOI: 10.1097/00002030-199907090-00003  0.494
1997 Silvestri G, Munoz C, Butini L, Bagnarelli P, Montroni M. Changes in CD8 Cell Subpopulations Induced by Antiretroviral Therapy in Human Immunodeficiency Virus Infected Patients Viral Immunology. 10: 207-212. PMID 9473151 DOI: 10.1089/Vim.1997.10.207  0.652
1997 Piedimonte G, Guetard D, Magnani M, Corsi D, Picerno I, Spataro P, Kramer L, Montroni M, Silvestri G, Torres Roca JF, Montagnier L. Oxidative protein damage and degradation in lymphocytes from patients infected with human immunodeficiency virus. The Journal of Infectious Diseases. 176: 655-64. PMID 9291312 DOI: 10.1086/514087  0.366
1993 Piedimonte G, Montroni M, Silvestri G, Silvotti L, Donatini A, Rossi L, Borghetti AF, Magnani M. Phagocytosis reduces HIV-1 production in human monocytes/macrophages infected in vitro. Archives of Virology. 130: 463-9. PMID 8517797 DOI: 10.1007/Bf01309674  0.544
1992 Montroni M, Silvestri G, Butini L, Bartocci C, Regnery C, Danieli G. p24 antigenaemia as a predictor of good immunological responsiveness to zidovudine therapy in asymptomatic HIV infection. Aids. 6: 338-339. DOI: 10.1097/00002030-199203000-00020  0.46
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