| Year |
Citation |
Score |
| 2021 |
McClure A, Diffley J. Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation. Elife. 10. PMID 34387546 DOI: 10.7554/eLife.69726 |
0.365 |
|
| 2017 |
Zhou JC, Janska A, Goswami P, Renault L, Abid Ali F, Kotecha A, Diffley JF, Costa A. CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome. Proceedings of the National Academy of Sciences of the United States of America. PMID 28373564 DOI: 10.1073/Pnas.1700530114 |
0.416 |
|
| 2016 |
Yeeles JT, Janska A, Early A, Diffley JF. How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication. Molecular Cell. PMID 27989442 DOI: 10.1016/j.molcel.2016.11.017 |
0.448 |
|
| 2016 |
Kurat CF, Yeeles JT, Patel H, Early A, Diffley JF. Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates. Molecular Cell. PMID 27989438 DOI: 10.1016/j.molcel.2016.11.016 |
0.471 |
|
| 2016 |
Deegan TD, Yeeles JT, Diffley JF. Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation. The Embo Journal. PMID 26912723 DOI: 10.15252/embj.201593552 |
0.411 |
|
| 2016 |
Deegan TD, Diffley JF. MCM: one ring to rule them all. Current Opinion in Structural Biology. 37: 145-151. PMID 26866665 DOI: 10.1016/j.sbi.2016.01.014 |
0.425 |
|
| 2015 |
Douglas ME, Diffley JF. Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the MCM Complex. The Journal of Biological Chemistry. PMID 26719337 DOI: 10.1074/jbc.M115.707802 |
0.446 |
|
| 2015 |
Yeeles JT, Deegan TD, Janska A, Early A, Diffley JF. Regulated eukaryotic DNA replication origin firing with purified proteins. Nature. 519: 431-5. PMID 25739503 DOI: 10.1038/nature14285 |
0.453 |
|
| 2015 |
Morafraile EC, Diffley JF, Tercero JA, Segurado M. Checkpoint-dependent RNR induction promotes fork restart after replicative stress. Scientific Reports. 5: 7886. PMID 25601385 DOI: 10.1038/srep07886 |
0.368 |
|
| 2014 |
Coster G, Frigola J, Beuron F, Morris EP, Diffley JF. Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase. Molecular Cell. 55: 666-77. PMID 25087873 DOI: 10.1016/j.molcel.2014.06.034 |
0.315 |
|
| 2014 |
Hills SA, Diffley JF. DNA replication and oncogene-induced replicative stress. Current Biology : Cb. 24: R435-44. PMID 24845676 DOI: 10.1016/j.cub.2014.04.012 |
0.37 |
|
| 2014 |
On KF, Beuron F, Frith D, Snijders AP, Morris EP, Diffley JF. Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. The Embo Journal. 33: 605-20. PMID 24566989 DOI: 10.1002/embj.201387369 |
0.464 |
|
| 2013 |
Siddiqui K, On KF, Diffley JF. Regulating DNA replication in eukarya. Cold Spring Harbor Perspectives in Biology. 5. PMID 23838438 DOI: 10.1101/cshperspect.a012930 |
0.61 |
|
| 2013 |
Boos D, Yekezare M, Diffley JF. Identification of a heteromeric complex that promotes DNA replication origin firing in human cells. Science (New York, N.Y.). 340: 981-4. PMID 23704573 DOI: 10.1126/science.1237448 |
0.505 |
|
| 2013 |
Yekezare M, Gómez-González B, Diffley JF. Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally. Journal of Cell Science. 126: 1297-306. PMID 23645160 DOI: 10.1242/jcs.096701 |
0.455 |
|
| 2013 |
Frigola J, Remus D, Mehanna A, Diffley JF. ATPase-dependent quality control of DNA replication origin licensing. Nature. 495: 339-43. PMID 23474987 DOI: 10.1038/nature11920 |
0.428 |
|
| 2013 |
Coster G, Diffley J. ATP Binding and hydrolysis by the Mcm2-7 replicative helicase play distinct roles during origin licensing F1000research. 4. DOI: 10.7490/F1000Research.1093863.1 |
0.373 |
|
| 2012 |
Mehanna A, Diffley JF. Pre-replicative complex assembly with purified proteins. Methods (San Diego, Calif.). 57: 222-6. PMID 22732456 DOI: 10.1016/j.ymeth.2012.06.008 |
0.421 |
|
| 2012 |
Boos D, Frigola J, Diffley JF. Activation of the replicative DNA helicase: breaking up is hard to do. Current Opinion in Cell Biology. 24: 423-30. PMID 22424671 DOI: 10.1016/j.ceb.2012.01.011 |
0.409 |
|
| 2011 |
Diffley JF. Quality control in the initiation of eukaryotic DNA replication. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 366: 3545-53. PMID 22084381 DOI: 10.1098/rstb.2011.0073 |
0.367 |
|
| 2011 |
Boos D, Sanchez-Pulido L, Rappas M, Pearl LH, Oliver AW, Ponting CP, Diffley JF. Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. Current Biology : Cb. 21: 1152-7. PMID 21700459 DOI: 10.1016/J.Cub.2011.05.057 |
0.462 |
|
| 2011 |
Baxter J, Sen N, MartÃnez VL, De Carandini ME, Schvartzman JB, Diffley JF, Aragón L. Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes. Science (New York, N.Y.). 331: 1328-32. PMID 21393545 DOI: 10.1126/science.1201538 |
0.397 |
|
| 2010 |
Diffley JF. The many faces of redundancy in DNA replication control. Cold Spring Harbor Symposia On Quantitative Biology. 75: 135-42. PMID 21502406 DOI: 10.1101/sqb.2010.75.062 |
0.396 |
|
| 2010 |
Zegerman P, Diffley JF. Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature. 467: 474-8. PMID 20835227 DOI: 10.1038/Nature09373 |
0.332 |
|
| 2010 |
Sanchez-Pulido L, Diffley JF, Ponting CP. Homology explains the functional similarities of Treslin/Ticrr and Sld3. Current Biology : Cb. 20: R509-10. PMID 20620901 DOI: 10.1016/J.Cub.2010.05.021 |
0.497 |
|
| 2009 |
Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF. Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell. 139: 719-30. PMID 19896182 DOI: 10.1016/J.Cell.2009.10.015 |
0.44 |
|
| 2009 |
Omberg L, Meyerson JR, Kobayashi K, Drury LS, Diffley JF, Alter O. Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression. Molecular Systems Biology. 5: 312. PMID 19888207 DOI: 10.1038/Msb.2009.70 |
0.612 |
|
| 2009 |
Remus D, Diffley JF. Eukaryotic DNA replication control: lock and load, then fire. Current Opinion in Cell Biology. 21: 771-7. PMID 19767190 DOI: 10.1016/j.ceb.2009.08.002 |
0.394 |
|
| 2009 |
Zegerman P, Diffley JF. DNA replication as a target of the DNA damage checkpoint. Dna Repair. 8: 1077-88. PMID 19505853 DOI: 10.1016/J.Dnarep.2009.04.023 |
0.445 |
|
| 2009 |
Drury LS, Diffley JF. Factors affecting the diversity of DNA replication licensing control in eukaryotes. Current Biology : Cb. 19: 530-5. PMID 19285403 DOI: 10.1016/j.cub.2009.02.034 |
0.452 |
|
| 2008 |
Segurado M, Diffley JF. Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes & Development. 22: 1816-27. PMID 18593882 DOI: 10.1101/gad.477208 |
0.442 |
|
| 2008 |
Baxter J, Diffley JF. Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Molecular Cell. 30: 790-802. PMID 18570880 DOI: 10.1016/j.molcel.2008.04.019 |
0.463 |
|
| 2008 |
Zierhut C, Diffley JF. Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. The Embo Journal. 27: 1875-85. PMID 18511906 DOI: 10.1038/emboj.2008.111 |
0.432 |
|
| 2007 |
Zegerman P, Diffley JF. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature. 445: 281-5. PMID 17167417 DOI: 10.1038/Nature05432 |
0.451 |
|
| 2005 |
Mailand N, Diffley JF. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell. 122: 915-26. PMID 16153703 DOI: 10.1016/j.cell.2005.08.013 |
0.349 |
|
| 2004 |
Mimura S, Seki T, Tanaka S, Diffley JF. Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature. 431: 1118-23. PMID 15496876 DOI: 10.1038/nature03024 |
0.403 |
|
| 2004 |
Diffley JF. Regulation of early events in chromosome replication. Current Biology : Cb. 14: R778-86. PMID 15380092 DOI: 10.1016/j.cub.2004.09.019 |
0.368 |
|
| 2004 |
Wang X, Ira G, Tercero JA, Holmes AM, Diffley JF, Haber JE. Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae. Molecular and Cellular Biology. 24: 6891-9. PMID 15282291 DOI: 10.1128/Mcb.24.16.6891-6899.2004 |
0.435 |
|
| 2004 |
Early A, Drury LS, Diffley JF. Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 31-8. PMID 15065654 DOI: 10.1098/rstb.2003.1362 |
0.446 |
|
| 2004 |
Merrick CJ, Jackson D, Diffley JF. Visualization of altered replication dynamics after DNA damage in human cells. The Journal of Biological Chemistry. 279: 20067-75. PMID 14982920 DOI: 10.1074/jbc.M400022200 |
0.4 |
|
| 2003 |
Zegerman P, Diffley JF. Lessons in how to hold a fork. Nature Structural Biology. 10: 778-9. PMID 14513023 DOI: 10.1038/Nsb1003-778 |
0.421 |
|
| 2003 |
Tercero JA, Longhese MP, Diffley JF. A central role for DNA replication forks in checkpoint activation and response. Molecular Cell. 11: 1323-36. PMID 12769855 DOI: 10.1016/S1097-2765(03)00169-2 |
0.466 |
|
| 2001 |
Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, Bousset K, Furuya K, Diffley JF, Carr AM, Elledge SJ. Mrc1 transduces signals of DNA replication stress to activate Rad53. Nature Cell Biology. 3: 958-65. PMID 11715016 DOI: 10.1038/Ncb1101-958 |
0.431 |
|
| 2001 |
Labib K, Kearsey SE, Diffley JF. MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. Molecular Biology of the Cell. 12: 3658-67. PMID 11694596 DOI: 10.1091/Mbc.12.11.3658 |
0.305 |
|
| 2001 |
Perkins G, Drury LS, Diffley JF. Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis. The Embo Journal. 20: 4836-45. PMID 11532947 DOI: 10.1093/emboj/20.17.4836 |
0.314 |
|
| 2001 |
Schepers A, Ritzi M, Bousset K, Kremmer E, Yates JL, Harwood J, Diffley JF, Hammerschmidt W. Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus. The Embo Journal. 20: 4588-602. PMID 11500385 DOI: 10.1093/emboj/20.16.4588 |
0.449 |
|
| 2001 |
Tercero JA, Diffley JF. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature. 412: 553-7. PMID 11484057 DOI: 10.1038/35087607 |
0.46 |
|
| 2001 |
Diffley JF. DNA replication: building the perfect switch. Current Biology : Cb. 11: R367-70. PMID 11369250 DOI: 10.1016/S0960-9822(01)00196-8 |
0.352 |
|
| 2001 |
Labib K, Diffley JF. Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Current Opinion in Genetics & Development. 11: 64-70. PMID 11163153 DOI: 10.1016/S0959-437X(00)00158-1 |
0.47 |
|
| 2000 |
Seki T, Diffley JF. Stepwise assembly of initiation proteins at budding yeast replication origins in vitro. Proceedings of the National Academy of Sciences of the United States of America. 97: 14115-20. PMID 11121019 DOI: 10.1073/pnas.97.26.14115 |
0.401 |
|
| 2000 |
Labib K, Tercero JA, Diffley JF. Uninterrupted MCM2-7 function required for DNA replication fork progression. Science (New York, N.Y.). 288: 1643-7. PMID 10834843 DOI: 10.1126/Science.288.5471.1643 |
0.468 |
|
| 2000 |
Tercero JA, Labib K, Diffley JF. DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p. The Embo Journal. 19: 2082-93. PMID 10790374 DOI: 10.1093/Emboj/19.9.2082 |
0.415 |
|
| 1999 |
Labib K, Diffley JF, Kearsey SE. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nature Cell Biology. 1: 415-22. PMID 10559985 DOI: 10.1038/15649 |
0.301 |
|
| 1999 |
Santocanale C, Sharma K, Diffley JF. Activation of dormant origins of DNA replication in budding yeast. Genes & Development. 13: 2360-4. PMID 10500092 DOI: 10.1101/Gad.13.18.2360 |
0.363 |
|
| 1998 |
Santocanale C, Diffley JF. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature. 395: 615-8. PMID 9783589 DOI: 10.1038/27001 |
0.441 |
|
| 1998 |
Perkins G, Diffley JF. Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. Molecular Cell. 2: 23-32. PMID 9702188 |
0.418 |
|
| 1998 |
Desdouets C, Santocanale C, Drury LS, Perkins G, Foiani M, Plevani P, Diffley JF. Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha. The Embo Journal. 17: 4139-46. PMID 9670028 DOI: 10.1093/Emboj/17.14.4139 |
0.347 |
|
| 1997 |
Drury LS, Perkins G, Diffley JF. The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. The Embo Journal. 16: 5966-76. PMID 9312054 DOI: 10.1093/emboj/16.19.5966 |
0.425 |
|
| 1997 |
Santocanale C, Diffley JF. Genomic footprinting of budding yeast replication origins during the cell cycle. Methods in Enzymology. 283: 377-90. PMID 9251035 DOI: 10.1016/S0076-6879(97)83031-5 |
0.434 |
|
| 1997 |
Donovan S, Harwood J, Drury LS, Diffley JF. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proceedings of the National Academy of Sciences of the United States of America. 94: 5611-6. PMID 9159120 DOI: 10.1073/pnas.94.11.5611 |
0.448 |
|
| 1996 |
Santocanale C, Diffley JF. ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. The Embo Journal. 15: 6671-9. PMID 8978693 |
0.428 |
|
| 1996 |
Diffley JF. Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells. Genes & Development. 10: 2819-30. PMID 8918884 |
0.471 |
|
| 1996 |
Donovan S, Diffley JF. Replication origins in eukaroytes. Current Opinion in Genetics & Development. 6: 203-7. PMID 8722177 DOI: 10.1016/S0959-437X(96)80051-7 |
0.434 |
|
| 1996 |
Piatti S, Böhm T, Cocker JH, Diffley JF, Nasmyth K. Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes & Development. 10: 1516-31. PMID 8666235 DOI: 10.1101/Gad.10.12.1516 |
0.375 |
|
| 1996 |
Cocker JH, Piatti S, Santocanale C, Nasmyth K, Diffley JF. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature. 379: 180-2. PMID 8538771 DOI: 10.1038/379180A0 |
0.404 |
|
| 1995 |
Diffley JF. The initiation of DNA replication in the budding yeast cell division cycle. Yeast (Chichester, England). 11: 1651-70. PMID 8720069 DOI: 10.1002/yea.320111608 |
0.455 |
|
| 1995 |
Diffley JF, Cocker JH, Dowell SJ, Harwood J, Rowley A. Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle. Journal of Cell Science. Supplement. 19: 67-72. PMID 8655649 |
0.475 |
|
| 1995 |
Dahmann C, Diffley JF, Nasmyth KA. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Current Biology : Cb. 5: 1257-69. PMID 8574583 DOI: 10.1016/S0960-9822(95)00252-1 |
0.336 |
|
| 1995 |
Rowley A, Cocker JH, Harwood J, Diffley JF. Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. The Embo Journal. 14: 2631-41. PMID 7781615 |
0.441 |
|
| 1994 |
Rowley A, Dowell SJ, Diffley JF. Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges. Biochimica Et Biophysica Acta. 1217: 239-56. PMID 8148369 DOI: 10.1016/0167-4781(94)90283-6 |
0.387 |
|
| 1994 |
Dowell SJ, Romanowski P, Diffley JF. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science (New York, N.Y.). 265: 1243-6. PMID 8066465 |
0.403 |
|
| 1994 |
Diffley JF, Cocker JH, Dowell SJ, Rowley A. Two steps in the assembly of complexes at yeast replication origins in vivo. Cell. 78: 303-16. PMID 8044842 DOI: 10.1016/0092-8674(94)90299-2 |
0.475 |
|
| 1994 |
Diffley JF. Eukaryotic DNA replication. Current Opinion in Cell Biology. 6: 368-72. PMID 7917327 DOI: 10.1016/0955-0674(94)90028-0 |
0.439 |
|
| 1993 |
Peters B, Merezhinskaya N, Diffley JF, Noguchi CT. Protein-DNA interactions in the epsilon-globin gene silencer. The Journal of Biological Chemistry. 268: 3430-7. PMID 8429019 |
0.419 |
|
| 1993 |
Micklem G, Rowley A, Harwood J, Nasmyth K, Diffley JF. Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature. 366: 87-9. PMID 8232543 DOI: 10.1038/366087A0 |
0.506 |
|
| 1992 |
Diffley JF. Early events in eukaryotic DNA replication. Trends in Cell Biology. 2: 298-303. PMID 14731925 DOI: 10.1016/0962-8924(92)90119-8 |
0.458 |
|
| 1992 |
Diffley JF, Stillman B. DNA binding properties of an HMG1-related protein from yeast mitochondria. The Journal of Biological Chemistry. 267: 3368-74. PMID 1737791 |
0.524 |
|
| 1992 |
Diffley JF, Cocker JH. Protein-DNA interactions at a yeast replication origin. Nature. 357: 169-72. PMID 1579168 DOI: 10.1038/357169a0 |
0.513 |
|
| 1992 |
Diffley JF. Global regulators of chromosome function in yeast. Antonie Van Leeuwenhoek. 62: 25-33. PMID 1444333 DOI: 10.1007/BF00584460 |
0.471 |
|
| 1991 |
Diffley JF, Stillman B. A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 88: 7864-8. PMID 1881919 DOI: 10.1016/0962-8924(91)90009-X |
0.587 |
|
| 1990 |
Diffley JF, Stillman B. The initiation of chromosomal DNA replication in eukaryotes. Trends in Genetics : Tig. 6: 427-32. PMID 2087786 DOI: 10.1016/0168-9525(90)90305-P |
0.57 |
|
| 1989 |
Diffley JF, Stillman B. Transcriptional silencing and lamins. Nature. 342: 24. PMID 2682256 DOI: 10.1038/342024A0 |
0.46 |
|
| 1989 |
Diffley JF, Stillman B. Similarity between the transcriptional silencer binding proteins ABF1 and RAP1. Science (New York, N.Y.). 246: 1034-8. PMID 2511628 DOI: 10.1126/Science.2511628 |
0.586 |
|
| 1988 |
Diffley JF, Stillman B. Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. Proceedings of the National Academy of Sciences of the United States of America. 85: 2120-4. PMID 3281162 DOI: 10.1073/Pnas.85.7.2120 |
0.589 |
|
| 1988 |
Diffley JF. Affinity labeling the DNA polymerase alpha complex. Identification of subunits containing the DNA polymerase active site and an important regulatory nucleotide-binding site. The Journal of Biological Chemistry. 263: 19126-31. PMID 3143725 |
0.387 |
|
| 1988 |
Diffley JF. Affinity labeling the DNA polymerase alpha complex. I. Pyridoxal 5'-phosphate inhibition of DNA polymerase and DNA primase activities of the DNA polymerase alpha complex from Drosophila melanogaster embryos. The Journal of Biological Chemistry. 263: 14669-77. PMID 3139661 |
0.433 |
|
| 1986 |
Diffley JF, Stillman B. Purification of a cellular, double-stranded DNA-binding protein required for initiation of adenovirus DNA replication by using a rapid filter-binding assay. Molecular and Cellular Biology. 6: 1363-73. PMID 3785168 DOI: 10.1128/Mcb.6.5.1363 |
0.63 |
|
| 1986 |
Ostapchuk P, Diffley JF, Bruder JT, Stillman B, Levine AJ, Hearing P. Interaction of a nuclear factor with the polyomavirus enhancer region. Proceedings of the National Academy of Sciences of the United States of America. 83: 8550-4. PMID 3022296 DOI: 10.1073/Pnas.83.22.8550 |
0.57 |
|
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