Andrew M. Intlekofer, Ph.D. - Publications

Affiliations: 
2007 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Immunology, Molecular Biology, General Biology

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Holling GA, Chavel CA, Sharda AP, Lieberman MM, James CM, Lightman SM, Tong JH, Qiao G, Emmons TR, Giridharan T, Hou S, Intlekofer AM, Higashi RM, Fan TWM, Lane AN, et al. CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity. Cellular & Molecular Immunology. PMID 38233562 DOI: 10.1038/s41423-024-01124-2  0.509
2021 Schrecker C, Intlekofer AM. T cells critically depend on pyruvate oxidation. Cell Metabolism. 33: 1719-1720. PMID 34496227 DOI: 10.1016/j.cmet.2021.08.010  0.415
2020 Campbell C, Marchildon F, Michaels AJ, Takemoto N, van der Veeken J, Schizas M, Pritykin Y, Leslie CS, Intlekofer AM, Cohen P, Rudensky AY. FXR mediates T cell-intrinsic responses to reduced feeding during infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 33318189 DOI: 10.1073/pnas.2020619117  0.473
2020 Stahl M, Epstein-Peterson ZD, Intlekofer AM. Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and Lymphoma. Cold Spring Harbor Perspectives in Medicine. PMID 32816875 DOI: 10.1101/Cshperspect.A035477  0.336
2020 Madala HR, Helenius IT, Zhou W, Mills E, Zhang Y, Liu Y, Metelo AM, Kelley ML, Punganuru S, Kim KB, Olenchock B, Rhee E, Intlekofer AM, Lliopoulos O, Chouchani E, et al. Nitrogen trapping as a therapeutic strategy in tumors with mitochondrial dysfunction. Cancer Research. PMID 32651261 DOI: 10.1158/0008-5472.Can-20-0246  0.324
2020 Kingsley MC, Xie HM, Chen BR, Riedel SS, Pastuer T, Bollig MK, Shank T, Libbrecht C, Stabler SP, Deshpande AJ, Intlekofer AM, Bernt KM. Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML. Blood Advances. 4: 3109-3122. PMID 32634241 DOI: 10.1182/Bloodadvances.2020001922  0.318
2018 Intlekofer AM, Joffe E, Batlevi CL, Hilden P, He J, Seshan VE, Zelenetz AD, Palomba ML, Moskowitz CH, Portlock C, Straus DJ, Noy A, Horwitz SM, Gerecitano JF, Moskowitz A, et al. Integrated DNA/RNA targeted genomic profiling of diffuse large B-cell lymphoma using a clinical assay. Blood Cancer Journal. 8: 60. PMID 29895903 DOI: 10.1038/S41408-018-0089-0  0.323
2018 McKenney AS, Lau AN, Somasundara AVH, Spitzer B, Intlekofer AM, Ahn J, Shank K, Rapaport FT, Patel MA, Papalexi E, Shih AH, Chiu A, Freinkman E, Akbay EA, Steadman M, et al. JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition. The Journal of Clinical Investigation. PMID 29355841 DOI: 10.1172/Jci94516  0.327
2018 Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, Rabinowitz JD, Thompson CB, Zhang J. As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. Cell Metabolism. PMID 29337136 DOI: 10.1016/J.Cmet.2017.12.006  0.303
2017 Shih AH, Meydan C, Shank K, Garrett-Bakelman FE, Ward PS, Intlekofer A, Nazir A, Stein E, Knapp K, Glass J, Travins J, Straley K, Gliser C, Mason C, Yen K, et al. Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia. Cancer Discovery. PMID 28193779 DOI: 10.1158/2159-8290.Cd-16-1049  0.315
2015 Mancebo SE, Smith JR, Intlekofer AM, Zelenetz AD, Myskowski PL. Treatment response of cutaneous mantle cell lymphoma to ibrutinib and radiotherapy. Clinical Lymphoma, Myeloma & Leukemia. 15: e113-5. PMID 25499623 DOI: 10.1016/J.Clml.2014.11.003  0.323
2015 Morley S, He J, Intlekofer AM, Bailey M, Nahas M, Lipson D, Yelensky R, Ross J, Ali S, Erlich R, Stephens P, Miller VA, Vergilio J, Mughal TI. Comprehensive Genomic Profiling (CGP) of Angioimmunoblastic T-Cell Lymphoma (AITL) to Prospectively Inform Diagnosis and Clinical Management Blood. 126: 3898-3898. DOI: 10.1182/Blood.V126.23.3898.3898  0.353
2015 Batlevi C, Rapaport F, Wang L, Intlekofer AM, Copeland AR, Jungbluth AA, Reiner A, Pichardo JD, Gallagher M, Bouvier N, Socci ND, Criscuolo F, Schultz N, Arcila M, Berger M, et al. Distinctive Genomic Alterations in Testicular Diffuse Large B Cell Lymphoma Blood. 126: 3655-3655. DOI: 10.1182/Blood.V126.23.3655.3655  0.319
2014 Intlekofer AM, Younes A. From empiric to mechanism-based therapy for peripheral T cell lymphoma. International Journal of Hematology. 99: 249-62. PMID 24510453 DOI: 10.1007/S12185-014-1521-2  0.434
2014 Shih AH, Shank KR, Meydan C, Intlekofer AM, Ward P, Thompson CB, Melnick AM, Travins J, Straley K, Gliser C, Yen K, Levine RL. AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo Blood. 124: 437-437. DOI: 10.1182/Blood.V124.21.437.437  0.318
2013 Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, et al. Induction of sarcomas by mutant IDH2. Genes & Development. 27: 1986-98. PMID 24065766 DOI: 10.1101/Gad.226753.113  0.357
2013 Intlekofer AM, Thompson CB. At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy Journal of Leukocyte Biology. 94: 25-39. PMID 23625198 DOI: 10.1189/Jlb.1212621  0.354
2013 Intlekofer AM, Sheshan VE, Levine RL, Zelenetz AD, Teruya-Feldstein J, Dogan A, Palomba ML, Moskowitz CH, van den Brink MRM, Knapp KM, Copeland ARM, Pichardo JD, Brennan KW, Young G, He J, et al. Profiling Genomic Alterations Of Diffuse Large B-Cell Lymphoma (DLBCL) At Diagnosis, Relapse, and Transformation, Using a Novel Clinical Diagnostic Targeted Sequencing Platform Blood. 122: 1761-1761. DOI: 10.1182/Blood.V122.21.1761.1761  0.301
2013 Du Rocher B, Smith OM, Intlekofer AM, Dudakov JA, Levy E, Kreiners F, Reiner S, Abdelhay E, van den Brink MR, Hanash AM. Eomesodermin Regulates The Early Activation Of Alloreactive CD4 T Cells and Is Critical For Both Gvh and GVL Responses Blood. 122: 133-133. DOI: 10.1182/Blood.V122.21.133.133  0.756
2011 Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, Intlekofer AM, Boss JM, Reiner SL, Weinmann AS, Wherry EJ. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nature Immunology. 12: 663-71. PMID 21623380 DOI: 10.1038/Ni.2046  0.718
2010 Kinjyo I, Gordon SM, Intlekofer AM, Dowdell K, Mooney EC, Caricchio R, Grupp SA, Teachey DT, Rao VK, Lindsten T, Reiner SL. Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. Journal of Immunology (Baltimore, Md. : 1950). 185: 7151-5. PMID 21076068 DOI: 10.4049/Jimmunol.1003193  0.767
2010 Banerjee A, Gordon SM, Intlekofer AM, Paley MA, Mooney EC, Lindsten T, Wherry EJ, Reiner SL. Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. Journal of Immunology (Baltimore, Md. : 1950). 185: 4988-92. PMID 20935204 DOI: 10.4049/Jimmunol.1002042  0.769
2009 Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, Wherry EJ. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity. 31: 309-20. PMID 19664943 DOI: 10.1016/J.Immuni.2009.06.019  0.738
2009 Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes & Development. 23: 1665-76. PMID 19605688 DOI: 10.1101/Gad.1793709  0.462
2009 Banerjee A, Gordon SM, Intlekofer AM, Wherry EJ, Reiner SL. Defective Central Memory CD8+ T Cell Differentiation in the Absence of Eomesodermin. Blood. 114: 2662-2662. DOI: 10.1182/Blood.V114.22.2662.2662  0.749
2008 Intlekofer AM, Banerjee A, Takemoto N, Gordon SM, Dejong CS, Shin H, Hunter CA, Wherry EJ, Lindsten T, Reiner SL. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science (New York, N.Y.). 321: 408-11. PMID 18635804 DOI: 10.1126/Science.1159806  0.757
2007 Intlekofer AM, Takemoto N, Kao C, Banerjee A, Schambach F, Northrop JK, Shen H, Wherry EJ, Reiner SL. Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. The Journal of Experimental Medicine. 204: 2015-21. PMID 17698591 DOI: 10.1084/Jem.20070841  0.77
2007 Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (New York, N.Y.). 315: 1687-91. PMID 17332376 DOI: 10.1126/Science.1139393  0.774
2007 Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 2730-6. PMID 17312115 DOI: 10.4049/Jimmunol.178.5.2730  0.74
2007 Jenkinson SR, Intlekofer AM, Sun G, Feigenbaum L, Reiner SL, Bosselut R. Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation. The Journal of Experimental Medicine. 204: 267-72. PMID 17296789 DOI: 10.1084/Jem.20061982  0.711
2007 Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and transcriptional programs lead to default IFN-γ production by γδ T cells The Journal of Immunology. 178: 5401.2-5401. DOI: 10.4049/jimmunol.178.8.5401-a  0.62
2006 Takemoto N, Intlekofer AM, Northrup JT, Wherry EJ, Reiner SL. Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. Journal of Immunology (Baltimore, Md. : 1950). 177: 7515-9. PMID 17114419 DOI: 10.4049/Jimmunol.177.11.7515  0.725
2006 Intlekofer AM, Wherry EJ, Reiner SL. Not-so-great expectations: re-assessing the essence of T-cell memory. Immunological Reviews. 211: 203-13. PMID 16824129 DOI: 10.1111/J.0105-2896.2006.00396.X  0.698
2006 Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, et al. Erratum: Corrigendum: Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin Nature Immunology. 7: 113-113. DOI: 10.1038/Ni0106-113  0.726
2005 Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nature Immunology. 6: 1236-44. PMID 16273099 DOI: 10.1038/Ni1268  0.755
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