Bradley T. Hyman, MD PhD - Publications

Affiliations: 
Neurology Massachusetts General Hospital and Harvard University, Boston, MA, United States 
Area:
neuropathophysiologic and genetic factors that underlie dementia.
Website:
http://dms.hms.harvard.edu/neuroscience/fac/hyman.php

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Miller MB, Huang AY, Kim J, Zhou Z, Kirkham SL, Maury EA, Ziegenfuss JS, Reed HC, Neil JE, Rento L, Ryu SC, Ma CC, Luquette LJ, Ames HM, Oakley DH, ... ... Hyman BT, et al. Somatic genomic changes in single Alzheimer's disease neurons. Nature. PMID 35444284 DOI: 10.1038/s41586-022-04640-1  0.338
2022 Dujardin S, Fernandes A, Bannon R, Commins C, De Los Santos M, Kamath TV, Hayashi M, Hyman BT. Tau propagation is dependent on the genetic background of mouse strains. Brain Communications. 4: fcac048. PMID 35350555 DOI: 10.1093/braincomms/fcac048  0.753
2022 Muñoz-Castro C, Noori A, Magdamo CG, Li Z, Marks JD, Frosch MP, Das S, Hyman BT, Serrano-Pozo A. Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease. Journal of Neuroinflammation. 19: 30. PMID 35109872 DOI: 10.1186/s12974-022-02383-4  0.831
2021 Bryant AG, Manhard MK, Salat DH, Rosen BR, Hyman BT, Johnson KA, Huang S, Bennett RE, Yen YF. Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD. Current Alzheimer Research. PMID 34825871 DOI: 10.2174/1567205018666211126113904  0.396
2021 Petrozziello T, Amaral AC, Dujardin S, Farhan SMK, Chan J, Trombetta BA, Kivisäkk P, Mills AN, Bordt EA, Kim SE, Dooley PM, Commins C, Connors TR, Oakley DH, Ghosal A, ... ... Hyman BT, et al. Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain Pathology (Zurich, Switzerland). e13035. PMID 34779076 DOI: 10.1111/bpa.13035  0.802
2021 Petrozziello T, Bordt EA, Mills AN, Kim SE, Sapp E, Devlin BA, Obeng-Marnu AA, Farhan SMK, Amaral AC, Dujardin S, Dooley PM, Henstridge C, Oakley DH, Neueder A, Hyman BT, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Molecular Neurobiology. PMID 34757590 DOI: 10.1007/s12035-021-02557-w  0.79
2021 Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, ... ... Hyman BT, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. PMID 34719765 DOI: 10.1007/s00401-021-02379-z  0.597
2021 Meisl G, Hidari E, Allinson K, Rittman T, DeVos SL, Sanchez JS, Xu CK, Duff KE, Johnson KA, Rowe JB, Hyman BT, Knowles TPJ, Klenerman D. In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease. Science Advances. 7: eabh1448. PMID 34714685 DOI: 10.1126/sciadv.abh1448  0.333
2021 Lee MJ, Wang C, Carroll MJ, Brubaker DK, Hyman BT, Lauffenburger DA. Computational Interspecies Translation Between Alzheimer's Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging. Frontiers in Neuroscience. 15: 727784. PMID 34658769 DOI: 10.3389/fnins.2021.727784  0.303
2021 Sexton C, Snyder H, Beher D, Boxer AL, Brannelly P, Brion JP, Buée L, Cacace AM, Chételat G, Citron M, DeVos SL, Diaz K, Feldman HH, Frost B, Goate AM, ... ... Hyman B, et al. Current directions in tau research: Highlights from Tau 2020. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34581500 DOI: 10.1002/alz.12452  0.542
2021 Fernandes AR, Dujardin S, Maté de Gérando A, Hyman BT, Frosch MP. Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds. Journal of Neuropathology and Experimental Neurology. PMID 34498073 DOI: 10.1093/jnen/nlab087  0.772
2021 Rodriguez S, Sahin A, Schrank BR, Al-Lawati H, Costantino I, Benz E, Fard D, Albers AD, Cao L, Gomez AC, Evans K, Ratti E, Cudkowicz M, Frosch MP, Talkowski M, ... ... Hyman BT, et al. Genome-encoded cytoplasmic double-stranded RNAs, found in ALS-FTD brain, propagate neuronal loss. Science Translational Medicine. 13. PMID 34233951 DOI: 10.1126/scitranslmed.aaz4699  0.459
2021 Kamath TV, Klickstein N, Commins C, Fernandes AR, Oakley DH, Frosch MP, Hyman BT, Dujardin S. Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer's cases. Brain Communications. 3: fcab096. PMID 34222869 DOI: 10.1093/braincomms/fcab096  0.835
2021 Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandres-Ciga S, D'Sa K, Reynolds RH, Botía JA, Losa M, Lysenko V, Carta M, Heinzer D, Avar M, Chincisan A, ... ... Hyman BT, et al. An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein. Cell Reports. 35: 109189. PMID 34107263 DOI: 10.1016/j.celrep.2021.109189  0.693
2021 Dickson JR, Yoon H, Frosch MP, Hyman BT. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. Journal of Neuropathology and Experimental Neurology. PMID 33990839 DOI: 10.1093/jnen/nlab040  0.781
2021 Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT. Alzheimer disease. Nature Reviews. Disease Primers. 7: 33. PMID 33986301 DOI: 10.1038/s41572-021-00269-y  0.381
2021 Madrasi K, Das R, Mohmmadabdul H, Lin L, Hyman BT, Lauffenburger DA, Albers MW, Rissman RA, Burke JM, Apgar JF, Wille L, Gruenbaum L, Hua F. Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33938131 DOI: 10.1002/alz.12312  0.314
2021 Cooper JM, Lathuiliere A, Migliorini M, Arai AL, Wani MM, Dujardin S, Muratoglu SC, Hyman BT, Strickland DK. Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism. The Journal of Biological Chemistry. 100715. PMID 33930462 DOI: 10.1016/j.jbc.2021.100715  0.763
2021 Oakley DH, Klickstein N, Commins C, Chung M, Dujardin S, Bennett RE, Hyman BT, Frosch MP. Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33893219 DOI: 10.1523/JNEUROSCI.2590-20.2021  0.837
2021 Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, ... ... Hyman BT, et al. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature Communications. 12: 2238. PMID 33854069 DOI: 10.1038/s41467-021-22501-9  0.731
2021 William CM, Stern MA, Pei X, Saqran L, Ramani M, Frosch MP, Hyman BT. Impairment of visual cortical plasticity by amyloid-beta species. Neurobiology of Disease. 154: 105344. PMID 33766652 DOI: 10.1016/j.nbd.2021.105344  0.578
2021 Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, ... ... Hyman BT, et al. Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Science Advances. 7. PMID 33741591 DOI: 10.1126/sciadv.abe1611  0.738
2021 Litvinchuk A, Huynh TV, Shi Y, Jackson RJ, Finn MB, Manis M, Francis CM, Tran A, Sullivan PM, Ulrich JD, Hyman BT, Cole T, Holtzman DM. ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model. Annals of Neurology. PMID 33550655 DOI: 10.1002/ana.26043  0.35
2021 Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, ... ... Hyman BT, et al. Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature Medicine. PMID 33514949 DOI: 10.1038/s41591-021-01251-7  0.829
2021 Serrano-Pozo A, Das S, Hyman BT. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. The Lancet. Neurology. 20: 68-80. PMID 33340485 DOI: 10.1016/S1474-4422(20)30412-9  0.312
2021 Lathuiliere A, Hyman BT. Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids Frontiers in Neuroscience. 15. DOI: 10.3389/fnins.2021.654176  0.348
2020 Noori A, Mezlini AM, Hyman BT, Serrano-Pozo A, Das S. Systematic review and meta-analysis of human Transcriptomics reveals Neuroinflammation, deficient energy metabolism, and Proteostasis failure across Neurodegeneration. Neurobiology of Disease. 105225. PMID 33347974 DOI: 10.1016/j.nbd.2020.105225  0.332
2020 Sepulveda-Falla D, Chavez-Gutierrez L, Portelius E, Vélez JI, Dujardin S, Barrera-Ocampo A, Dinkel F, Hagel C, Puig B, Mastronardi C, Lopera F, Hyman BT, Blennow K, Arcos-Burgos M, de Strooper B, et al. A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease. Acta Neuropathologica. PMID 33319314 DOI: 10.1007/s00401-020-02249-0  0.772
2020 Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, ... ... Hyman BT, et al. Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell. PMID 33188775 DOI: 10.1016/j.cell.2020.10.029  0.786
2020 Perez-Rando M, Dujardin S, Bennett RE, Commins C, Nibhanupudy T, Hyman BT. Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta Neuropathologica Communications. 8: 168. PMID 33076986 DOI: 10.1186/s40478-020-01049-7  0.734
2020 Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, ... ... Hyman BT, et al. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. Jama Neurology. PMID 33074286 DOI: 10.1001/jamaneurol.2020.3536  0.539
2020 Bryant AG, Hu M, Carlyle BC, Arnold SE, Frosch MP, Das S, Hyman BT, Bennett RE. Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. Frontiers in Neurology. 11: 575953. PMID 33041998 DOI: 10.3389/Fneur.2020.575953  0.618
2020 Wurts A, Oakley DH, Hyman BT, Samsi S. Segmentation of Tau Stained Alzheimers Brain Tissue Using Convolutional Neural Networks. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference. 2020: 1420-1423. PMID 33018256 DOI: 10.1109/EMBC44109.2020.9175832  0.733
2020 Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, et al. Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. Journal of Neuropathology and Experimental Neurology. PMID 33000167 DOI: 10.1093/jnen/nlaa109  0.488
2020 Bennett RE, Hu M, Fernandes A, Perez-Rando M, Robbins A, Kamath T, Dujardin S, Hyman BT. Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathologica Communications. 8: 137. PMID 32811565 DOI: 10.1186/S40478-020-01014-4  0.777
2020 Busche MA, Hyman BT. Synergy between amyloid-β and tau in Alzheimer's disease. Nature Neuroscience. PMID 32778792 DOI: 10.1038/S41593-020-0687-6  0.524
2020 Das S, Li Z, Noori A, Hyman BT, Serrano-Pozo A. Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration. Journal of Neuroinflammation. 17: 227. PMID 32736565 DOI: 10.1186/S12974-020-01898-Y  0.691
2020 Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, ... ... Hyman BT, et al. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature Medicine. PMID 32572268 DOI: 10.1038/S41591-020-0938-9  0.843
2020 Huh YE, Ruby Chiang MS, Locascio JJ, Liao Z, Liu G, Choudhury K, Kuras YI, Tuncali I, Videnovic A, Hunt AL, Schwarzschild MA, Hung AY, Herrington TM, Hayes MT, Hyman BT, et al. β-Glucocerebrosidase Activity in -linked Parkinson's Disease: The Type of Mutation Matters. Neurology. PMID 32540937 DOI: 10.1212/Wnl.0000000000009989  0.635
2020 Cable J, Holtzman DM, Hyman BT, Tansey MG, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Annals of the New York Academy of Sciences. PMID 32472577 DOI: 10.1111/Nyas.14371  0.442
2020 Oakley DH, Chung M, Klickstein N, Commins C, Hyman BT, Frosch MP. The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue. Journal of Neuropathology and Experimental Neurology. PMID 32388561 DOI: 10.1093/Jnen/Nlaa025  0.81
2020 Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. LRP1 is a master regulator of tau uptake and spread. Nature. 580: 381-385. PMID 32296178 DOI: 10.1038/S41586-020-2156-5  0.77
2020 Bakshi R, Macklin EA, Hung AY, Hayes MT, Hyman BT, Wills AM, Gomperts SN, Growdon JH, Ascherio A, Scherzer CR, Schwarzschild MA. Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson's Disease in the Harvard Biomarkers Study. Journal of Parkinson's Disease. 10: 505-510. PMID 32250320 DOI: 10.3233/Jpd-191882  0.619
2020 Benetatos J, Bennett RE, Evans HT, Ellis SA, Hyman BT, Bodea LG, Götz J. PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy. Acta Neuropathologica. PMID 32236736 DOI: 10.1007/S00401-020-02151-9  0.439
2020 Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, ... ... Hyman BT, et al. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications. 11: 667. PMID 32015339 DOI: 10.1038/S41467-019-14279-8  0.606
2019 Dujardin S, Hyman BT. Tau Prion-Like Propagation: State of the Art and Current Challenges. Advances in Experimental Medicine and Biology. 1184: 305-325. PMID 32096046 DOI: 10.1007/978-981-32-9358-8_23  0.757
2019 Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, ... ... Hyman BT, et al. α-Synuclein strains target distinct brain regions and cell types. Nature Neuroscience. PMID 31792467 DOI: 10.1038/S41593-019-0541-X  0.338
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Hyman BT, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.649
2019 Gui Y, Marks JD, Das S, Hyman BT, Serrano-Pozo A. Characterization of the 18 kda translocator protein (tspo) expression in post-mortem normal and alzheimer's disease brains. Brain Pathology (Zurich, Switzerland). PMID 31276244 DOI: 10.1111/Bpa.12763  0.792
2019 Wegmann S, Bennett RE, Delorme L, Robbins AB, Hu M, McKenzie D, Kirk MJ, Schiantarelli J, Tunio N, Amaral AC, Fan Z, Nicholls S, Hudry E, Hyman BT. Experimental evidence for the age dependence of tau protein spread in the brain. Science Advances. 5: eaaw6404. PMID 31249873 DOI: 10.1126/Sciadv.Aaw6404  0.842
2019 Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, ... Hyman B, et al. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Reports. 27: 1293-1306.e6. PMID 31018141 DOI: 10.1016/J.Celrep.2019.03.099  0.424
2019 Bihlmeyer NA, Merrill E, Lambert Y, Srivastava GP, Clark TW, Hyman BT, Das S. Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30935898 DOI: 10.1016/J.Jalz.2019.01.011  0.403
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Hyman BT, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.638
2019 Hudry E, Klickstein J, Cannavo C, Jackson R, Muzikansky A, Gandhi S, Urick D, Sargent T, Wrobleski L, Roe AD, Hou SS, Kuchibhotla KV, Betensky RA, Spires-Jones T, Hyman BT. Opposing Roles of apolipoprotein E in aging and neurodegeneration. Life Science Alliance. 2. PMID 30760557 DOI: 10.26508/lsa.201900325  0.646
2019 Hyman B, Tanzi RE. Effects of Species-Specific Genetics on Alzheimer's Mouse Models. Neuron. 101: 351-352. PMID 30731053 DOI: 10.1016/J.Neuron.2019.01.021  0.416
2019 Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, ... ... Hyman BT, et al. Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain : a Journal of Neurology. PMID 30689776 DOI: 10.1093/Brain/Awy327  0.454
2019 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, ... ... Hyman BT, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031  0.83
2019 Henstridge CM, Hyman BT, Spires-Jones TL. Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nature Reviews. Neuroscience. 20: 94-108. PMID 30643230 DOI: 10.1038/S41583-018-0113-1  0.813
2019 Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nature Neuroscience. 22: 57-64. PMID 30559471 DOI: 10.1038/S41593-018-0289-8  0.85
2019 Dujardin S, Commins C, Kamath TV, De Los Santos M, Dooley PM, Moore BD, Jean-Gilles D, Clark R, Kennedy M, Hyman BT. RELEVANCE OF TAU SEEDING FOR THE CLINICAL HETEROGENEITY OF ALZHEIMER’S DISEASE: IMPLICATION FOR THERAPEUTIC PERSPECTIVES Alzheimer's & Dementia. 15: P1623. DOI: 10.1016/J.Jalz.2019.06.4854  0.732
2018 Dujardin S, Bégard S, Caillierez R, Lachaud C, Carrier S, Lieger S, Gonzalez JA, Deramecourt V, Déglon N, Maurage CA, Frosch MP, Hyman BT, Colin M, Buée L. Different tau species lead to heterogeneous tau pathology propagation and misfolding. Acta Neuropathologica Communications. 6: 132. PMID 30497516 DOI: 10.1186/S40478-018-0637-7  0.842
2018 Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, ... ... Hyman BT, et al. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathologica. PMID 30413934 DOI: 10.1007/S00401-018-1928-6  0.398
2018 Bennett RE, Bryant A, Hu M, Robbins AB, Hopp SC, Hyman BT. Partial reduction of microglia does not affect tau pathology in aged mice. Journal of Neuroinflammation. 15: 311. PMID 30413160 DOI: 10.1186/S12974-018-1348-5  0.787
2018 Hopp SC, Lin Y, Oakley D, Roe AD, DeVos SL, Hanlon D, Hyman BT. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. Journal of Neuroinflammation. 15: 269. PMID 30227881 DOI: 10.1186/S12974-018-1309-Z  0.852
2018 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, ... ... Hyman BT, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 99: 925-940.e7. PMID 30189209 DOI: 10.1016/J.Neuron.2018.07.039  0.858
2018 Wu HY, Kuo PC, Wang YT, Lin HT, Roe AD, Wang BY, Han CL, Hyman BT, Chen YJ, Tai HC. β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals. Journal of Neuropathology and Experimental Neurology. PMID 30016458 DOI: 10.1093/Jnen/Nly059  0.487
2018 Kara E, Marks JD, Roe AD, Commins C, Fan Z, Calvo-Rodriguez M, Wegmann S, Hudry E, Hyman BT. A  flow cytometry-based in vitro assay reveals that formation of apolipoprotein E (ApoE)-amyloid beta complexes depends on ApoE isoform- and cell type. The Journal of Biological Chemistry. PMID 29950521 DOI: 10.1074/Jbc.Ra117.001388  0.733
2018 Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, ... ... Hyman BT, et al. Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.). 360. PMID 29930110 DOI: 10.1126/Science.Aap8757  0.432
2018 György B, Lööv C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, et al. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Molecular Therapy. Nucleic Acids. 11: 429-440. PMID 29858078 DOI: 10.1016/J.Omtn.2018.03.007  0.481
2018 Hopp SC, Bihlmeyer NA, Corradi JP, Vanderburg C, Cacace AM, Das S, Clark TW, Betensky RA, Hyman BT, Hudry E. Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain. Journal of Neurochemistry. PMID 29806693 DOI: 10.1111/Jnc.14469  0.784
2018 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ and brain Aβ deposition . The Journal of Biological Chemistry. 293: 7267. PMID 29752420 DOI: 10.1074/jbc.AAC118.003576  0.69
2018 DeVos SL, Corjuc BT, Oakley DH, Nobuhara CK, Bannon RN, Chase A, Commins C, Gonzalez JA, Dooley PM, Frosch MP, Hyman BT. Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain. Frontiers in Neuroscience. 12: 267. PMID 29740275 DOI: 10.3389/Fnins.2018.00267  0.831
2018 DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, ... ... Hyman BT, et al. Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo. Brain : a Journal of Neurology. PMID 29733334 DOI: 10.1093/Brain/Awy117  0.815
2018 Mari SA, Wegmann S, Tepper K, Hyman BT, Mandelkow EM, Mandelkow E, Müller DJ. Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes. Nano Letters. PMID 29644863 DOI: 10.1021/Acs.Nanolett.8B01085  0.751
2018 Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, ... ... Hyman BT, et al. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of Clinical Investigation. PMID 29600961 DOI: 10.1172/Jci96429  0.465
2018 Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, ... ... Hyman BT, et al. Tau protein liquid-liquid phase separation can initiate tau aggregation. The Embo Journal. PMID 29472250 DOI: 10.15252/Embj.201798049  0.839
2018 György B, Cruz L, Yellen D, Aufiero M, Alland I, Zhang X, Ericsson M, Fraefel C, Li YC, Takeda S, Hyman BT, Breakefield XO. Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts. Scientific Reports. 8: 2324. PMID 29396398 DOI: 10.1038/S41598-018-19865-2  0.331
2018 Bennett RE, Robbins AB, Hu M, Cao X, Betensky RA, Clark T, Das S, Hyman BT. Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29358399 DOI: 10.1073/Pnas.1710329115  0.445
2017 Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, ... ... Hyman BT, et al. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathologica. PMID 29177679 DOI: 10.1007/S00401-017-1789-4  0.418
2017 Colom-Cadena M, Pegueroles J, Herrmann AG, Henstridge CM, Muñoz L, Querol-Vilaseca M, Martín-Paniello CS, Luque-Cabecerans J, Clarimon J, Belbin O, Núñez-Llaves R, Blesa R, Smith C, McKenzie CA, Frosch MP, ... ... Hyman BT, et al. Synaptic phosphorylated α-synuclein in dementia with Lewy bodies. Brain : a Journal of Neurology. 140: 3204-3214. PMID 29177427 DOI: 10.1093/Brain/Awx275  0.809
2017 Dumurgier J, Hanseeuw BJ, Hatling FB, Judge KA, Schultz AP, Chhatwal JP, Blacker D, Sperling RA, Johnson KA, Hyman BT, Gómez-Isla T. Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults. Journal of Alzheimer's Disease : Jad. PMID 29036824 DOI: 10.3233/Jad-170511  0.354
2017 Tan CH, Hyman BT, Tan JJX, Hess CP, Dillon WP, Schellenberg GD, Besser LM, Kukull WA, Kauppi K, McEvoy LK, Andreassen OA, Dale AM, Fan CC, Desikan RS. Polygenic hazard scores in preclinical Alzheimer disease. Annals of Neurology. 82: 484-488. PMID 28940650 DOI: 10.1002/Ana.25029  0.406
2017 William CM, Saqran L, Stern MA, Chiang CL, Herrick S, Rangwala A, Albers MW, Frosch MP, Hyman BT. Activity-dependent dysfunction in visual and olfactory sensory systems in mouse models of Down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28899917 DOI: 10.1523/Jneurosci.1045-17.2017  0.512
2017 Wegmann S, Bennett RE, Amaral AS, Hyman BT. Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses. Methods in Cell Biology. 141: 307-322. PMID 28882310 DOI: 10.1016/Bs.Mcb.2017.06.014  0.763
2017 Hernández-Vega A, Braun M, Scharrel L, Jahnel M, Wegmann S, Hyman BT, Alberti S, Diez S, Hyman AA. Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase. Cell Reports. 20: 2304-2312. PMID 28877466 DOI: 10.1016/j.celrep.2017.08.042  0.664
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Hyman BT, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.801
2017 Kara E, Marks JD, Fan Z, Klickstein JA, Roe AD, Krogh KA, Wegmann S, Maesako M, Luo CC, Mylvaganam R, Berezovska O, Hudry E, Hyman BT. Isoform and cell type-specific structure of Apolipoprotein E lipoparticles as revealed by a novel Forster Resonance Energy Transfer assay. The Journal of Biological Chemistry. PMID 28684412 DOI: 10.1074/Jbc.M117.784264  0.792
2017 Nicholls SB, DeVos SL, Commins C, Nobuhara C, Bennett RE, Corjuc DL, Maury E, Eftekharzadeh B, Akingbade O, Fan Z, Roe AD, Takeda S, Wegmann S, Hyman BT. Characterization of TauC3 antibody and demonstration of its potential to block tau propagation. Plos One. 12: e0177914. PMID 28531180 DOI: 10.1371/Journal.Pone.0177914  0.753
2017 DeVos SL, Hyman BT. Tau at the Crossroads between Neurotoxicity and Neuroprotection. Neuron. 94: 703-704. PMID 28521124 DOI: 10.1016/J.Neuron.2017.05.001  0.361
2017 Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT. Enhanced Tau Aggregation in the Presence of Amyloid β. The American Journal of Pathology. PMID 28500862 DOI: 10.1016/J.Ajpath.2017.03.011  0.815
2017 Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, ... ... Hyman BT, et al. Tau Antibody-Targeting Pathological Species Block Neuronal Uptake and Interneuron Propagation of Tau in Vitro. The American Journal of Pathology. PMID 28408124 DOI: 10.1016/J.Ajpath.2017.01.022  0.787
2017 Williams EA, McGuone D, Frosch MP, Hyman BT, Laver N, Stemmer-Rachamimov A. Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease. Journal of Neuropathology and Experimental Neurology. PMID 28379416 DOI: 10.1093/Jnen/Nlx020  0.645
2017 Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ. Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Molecular Neurodegeneration. 12: 27. PMID 28327181 DOI: 10.1186/S13024-017-0169-9  0.78
2017 Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, ... ... Hyman BT, et al. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Plos Medicine. 14: e1002258. PMID 28323831 DOI: 10.1371/Journal.Pmed.1002258  0.368
2017 Qian J, Hyman BT, Betensky RA. Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design. Jama Neurology. PMID 28288263 DOI: 10.1001/Jamaneurol.2016.5953  0.324
2017 Thaker AA, Weinberg BD, Dillon WP, Hess CP, Cabral HJ, Fleischman DA, Leurgans SE, Bennett DA, Hyman BT, Albert MS, Killiany RJ, Fischl B, Dale AM, Desikan RS. Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology. Ajnr. American Journal of Neuroradiology. PMID 28279988 DOI: 10.3174/Ajnr.A5133  0.327
2017 Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J, Momeni P, ... ... Hyman BT, et al. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathologica. PMID 28271184 DOI: 10.1007/S00401-017-1693-Y  0.589
2017 Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. Jama Neurology. PMID 28241163 DOI: 10.1001/Jamaneurol.2016.5755  0.473
2017 Pickett EK, Henstridge CM, Allison E, Pitstick R, Pooler A, Wegmann S, Carlson G, Hyman BT, Spires-Jones TL. Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease. Synapse (New York, N.Y.). PMID 28196395 DOI: 10.1002/Syn.21965  0.833
2017 Zoltowska KM, Maesako M, Lushnikova I, Takeda S, Keller LJ, Skibo G, Hyman BT, Berezovska O. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production. Molecular Neurodegeneration. 12: 15. PMID 28193235 DOI: 10.1186/S13024-017-0159-Y  0.428
2017 Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367. Elife. 6. PMID 28132667 DOI: 10.7554/Elife.19720  0.604
2016 Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, ... ... Hyman BT, et al. Pathologic correlations of [F-18]-AV-1451 imaging in non-Alzheimer tauopathies. Annals of Neurology. PMID 27997036 DOI: 10.1002/Ana.24844  0.822
2016 Dashkoff J, Lerner EP, Truong N, Klickstein JA, Fan Z, Mu D, Maguire CA, Hyman BT, Hudry E. Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9. Molecular Therapy. Methods & Clinical Development. 3: 16081. PMID 27933308 DOI: 10.1038/Mtm.2016.81  0.327
2016 Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson GA, Hyman BT, Spires-Jones TL. Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease. The European Journal of Neuroscience. PMID 27748574 DOI: 10.1111/Ejn.13442  0.847
2016 Wegmann S, Nicholls S, Takeda S, Fan Z, Hyman BT. Formation, release, and internalization of stable tau oligomers in cells. Journal of Neurochemistry. PMID 27731899 DOI: 10.1111/Jnc.13866  0.752
2016 Merkel SF, Andrews AM, Lutton EM, Mu D, Hudry E, Hyman BT, Maguire CA, Ramirez SH. Trafficking of AAV vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells. Journal of Neurochemistry. PMID 27718541 DOI: 10.1111/Jnc.13861  0.307
2016 Albers AD, Asafu-Adjei J, Delaney MK, Kelly KE, Gomez-Isla T, Blacker D, Johnson KA, Sperling RA, Hyman BT, Betensky RA, Hastings L, Albers MW. Episodic Memory of Odors Stratifies Alzheimer Biomarkers in Normal Elderly. Annals of Neurology. PMID 27696605 DOI: 10.1002/Ana.24792  0.382
2016 Liu J, Costantino I, Venugopalan N, Fischetti RF, Hyman BT, Frosch MP, Gomez-Isla T, Makowski L. Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue. Scientific Reports. 6: 33079. PMID 27629394 DOI: 10.1038/Srep33079  0.607
2016 Chung WS, Verghese PB, Chakraborty C, Joung J, Hyman BT, Ulrich JD, Holtzman DM, Barres BA. Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes. Proceedings of the National Academy of Sciences of the United States of America. PMID 27559087 DOI: 10.1073/Pnas.1609896113  0.398
2016 Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology. PMID 27473132 DOI: 10.1212/Wnl.0000000000003050  0.408
2016 Fu H, Hussaini SA, Wegmann S, Profaci C, Daniels JD, Herman M, Emrani S, Figueroa HY, Hyman BT, Davies P, Duff KE. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. Plos One. 11: e0159463. PMID 27466814 DOI: 10.1371/Journal.Pone.0159463  0.793
2016 Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, ... ... Hyman BT, et al. Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Annals of Neurology. PMID 27351289 DOI: 10.1002/Ana.24716  0.801
2016 Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL. Non-Fibrillar Oligomeric Amyloid-β within Synapses. Journal of Alzheimer's Disease : Jad. PMID 27258414 DOI: 10.3233/Jad-160007  0.832
2016 Beglopoulos V, Tulloch J, Roe AD, Daumas S, Ferrington L, Watson R, Fan Z, Hyman BT, Kelly PA, Bard F, Morris RG. Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice. Nature Communications. 7: 11761. PMID 27249364 DOI: 10.1038/Ncomms11761  0.388
2016 Rudinskiy N, Fuerer C, Demurtas D, Zamorano S, De Piano C, Herrmann A, Spires-Jones TL, Oeckl P, Otto M, Frosch MP, Moniatte M, Hyman BT, Schmid AW. Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27130892 DOI: 10.1016/J.Jalz.2016.03.011  0.836
2016 Serrano-Pozo A, Qian J, Muzikansky A, Monsell SE, Montine TJ, Frosch MP, Betensky RA, Hyman BT. Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum. Journal of Neuropathology and Experimental Neurology. PMID 27105663 DOI: 10.1093/Jnen/Nlw026  0.771
2016 Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, ... ... Hyman BT, et al. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. Jama Neurology. PMID 27088644 DOI: 10.1001/Jamaneurol.2016.0150  0.445
2016 Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. Bmc Biology. 14: 25. PMID 27036734 DOI: 10.1186/S12915-016-0248-3  0.42
2016 Eftekharzadeh B, Hyman BT, Wegmann S. Structural studies on the mechanism of protein aggregation in age related neurodegenerative diseases. Mechanisms of Ageing and Development. 156: 1-13. PMID 27005270 DOI: 10.1016/J.Mad.2016.03.001  0.705
2016 Lööv C, Scherzer CR, Hyman BT, Breakefield XO, Ingelsson M. α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities. Cellular and Molecular Neurobiology. PMID 26993503 DOI: 10.1007/S10571-015-0317-0  0.328
2016 Hudry E, Martin C, Gandhi S, György B, Scheffer DI, Mu D, Merkel SF, Mingozzi F, Fitzpatrick Z, Dimant H, Masek M, Ragan T, Tan S, Brisson AR, Ramirez SH, ... Hyman BT, et al. Exosome-associated AAV vector as a robust and convenient neuroscience tool. Gene Therapy. PMID 26836117 DOI: 10.1038/Gt.2016.11  0.783
2016 Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Author response: Pathogenic PS1 phosphorylation at Ser367 Elife. DOI: 10.7554/Elife.19720.023  0.507
2016 Silvestri L, Rudinskiy N, Paciscopi M, Müllenbroich MC, Costantini I, Sacconi L, Frasconi P, Hyman BT, Pavone FS. Mapping whole-brain activity with cellular resolution by light-sheet microscopy and high-throughput image analysis (Conference Presentation) Proceedings of Spie. 9690: 969012. DOI: 10.1117/12.2208603  0.317
2016 Hudry E, Dashkoff J, Lerner P, Takeda S, Truong N, Maguire C, Hyman BT. 616. Tailored Expression of a Transgene to Specific Cell Types in the Central Nervous System After Peripheral Injection of AAV9 Molecular Therapy. 24: S244. DOI: 10.1016/S1525-0016(16)33424-4  0.343
2016 Gyorgy B, Ingelsson M, Loov C, Takeda S, Lannfelt L, Hyman BT, Breakefield XO. 567. CRISPR-Cas9 Mediated Gene Editing in a Monogenic Form of Alzheimer's Disease Molecular Therapy. 24: S226-S227. DOI: 10.1016/S1525-0016(16)33375-5  0.324
2016 Hyman B. Tau and Alzheimer pathobiology Neurobiology of Aging. 39: S16. DOI: 10.1016/J.Neurobiolaging.2016.01.076  0.493
2016 Pickett E, Henstridge C, Jackson RJ, Herrmann AG, Wegmann S, Hyman BT, Carlson GA, Spires-Jones TL. EC-03-03: Tau Spreading and Toxicity Alzheimer's & Dementia. 12: P269-P269. DOI: 10.1016/J.Jalz.2016.06.2381  0.812
2015 Feke GT, Hyman BT, Stern RA, Pasquale LR. Retinal blood flow in mild cognitive impairment and Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 1: 144-51. PMID 27239502 DOI: 10.1016/J.Dadm.2015.01.004  0.343
2015 Serrano-Pozo A, Betensky RA, Frosch MP, Hyman BT. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. The American Journal of Pathology. PMID 26687817 DOI: 10.1016/J.Ajpath.2015.10.010  0.793
2015 Galea E, Morrison W, Hudry E, Arbel-Ornath M, Bacskai BJ, Gómez-Isla T, Stanley HE, Hyman BT. Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644572 DOI: 10.1073/Pnas.1516779112  0.615
2015 Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Scientific Reports. 5: 16622. PMID 26564777 DOI: 10.1038/Srep16622  0.835
2015 Serrano-Pozo A, Hyman BT. Alzheimer Disease: Alzheimer dementia with sparse amyloid-AD mimic or variant? Nature Reviews. Neurology. PMID 26553593 DOI: 10.1038/Nrneurol.2015.221  0.773
2015 Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, ... Hyman BT, et al. Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. The Embo Journal. PMID 26538322 DOI: 10.15252/Embj.201592748  0.846
2015 Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, ... ... Hyman B, et al. Tau PET imaging in aging and early Alzheimer's disease. Annals of Neurology. PMID 26505746 DOI: 10.1002/Ana.24546  0.472
2015 Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nature Communications. 6: 8490. PMID 26458742 DOI: 10.1038/Ncomms9490  0.802
2015 Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, ... ... Hyman BT, et al. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Annals of Neurology. PMID 26344059 DOI: 10.1002/Ana.24517  0.647
2015 Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, ... ... Hyman BT, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26327235 DOI: 10.1016/J.Jalz.2015.07.492  0.604
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887  0.579
2015 Toledo JB, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, ... ... Hyman BT, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a Journal of Neurology. 138: 2701-15. PMID 26220940 DOI: 10.1093/Brain/Awv199  0.435
2015 Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... ... Hyman BT, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain : a Journal of Neurology. 138: 2659-71. PMID 26220939 DOI: 10.1093/Brain/Awv202  0.676
2015 Arimon M, Takeda S, Post KL, Svirsky S, Hyman BT, Berezovska O. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiology of Disease. PMID 26102023 DOI: 10.1016/J.Nbd.2015.06.013  0.38
2015 Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M. Inhibition of amyloid-β plaque formation by α-synuclein. Nature Medicine. 21: 802-7. PMID 26099047 DOI: 10.1038/Nm.3885  0.761
2015 Yang Y, Keene CD, Peskind ER, Galasko DR, Hu SC, Cudaback E, Wilson AM, Li G, Yu CE, Montine KS, Zhang J, Baird GS, Hyman BT, Montine TJ. Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. Journal of Neuropathology and Experimental Neurology. 74: 672-87. PMID 26083568 DOI: 10.1097/Nen.0000000000000207  0.389
2015 von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper C, Boeckers TM, Rueck A, Wirth T, Hyman BT, Danzer KM, Thal DR, von Arnim CA. The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). Plos One. 10: e0129047. PMID 26053850 DOI: 10.1371/Journal.Pone.0129047  0.822
2015 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO. The Journal of Biological Chemistry. 290: 15163-74. PMID 25918154 DOI: 10.1074/Jbc.M114.622209  0.749
2015 Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, ... ... Hyman BT, et al. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 131: 2061-9. PMID 25862742 DOI: 10.1161/Circulationaha.115.015489  0.436
2015 Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta Neuropathologica Communications. 3: 14. PMID 25853174 DOI: 10.1186/S40478-015-0199-X  0.845
2015 Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimer's Research & Therapy. 7: 14. PMID 25802556 DOI: 10.1186/S13195-015-0100-Y  0.397
2015 Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, et al. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathologica. 129: 757-62. PMID 25778618 DOI: 10.1007/S00401-015-1407-2  0.487
2015 Kaushal V, Dye R, Pakavathkumar P, Foveau B, Flores J, Hyman B, Ghetti B, Koller BH, LeBlanc AC. Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation. Cell Death and Differentiation. PMID 25744023 DOI: 10.1038/Cdd.2015.16  0.392
2015 Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen CH, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, ... ... Hyman BT, et al. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Molecular Psychiatry. PMID 25687773 DOI: 10.1038/Mp.2015.6  0.406
2015 Serrano-Pozo A, Qian J, Monsell SE, Betensky RA, Hyman BT. APOEε2 is associated with milder clinical and pathological Alzheimer disease. Annals of Neurology. 77: 917-29. PMID 25623662 DOI: 10.1002/Ana.24369  0.762
2015 Hyman BT, Holtzman DM. Apolipoprotein E levels and Alzheimer risk. Annals of Neurology. 77: 204-5. PMID 25583643 DOI: 10.1002/Ana.24355  0.32
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Hyman BT, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.696
2015 Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E. A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease. The Journal of Biological Chemistry. 290: 1966-78. PMID 25468905 DOI: 10.1074/Jbc.M114.586602  0.727
2015 Saidi LJ, Polydoro M, Kay KR, Sanchez L, Mandelkow EM, Hyman BT, Spires-Jones TL. Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. Journal of Alzheimer's Disease : Jad. 44: 937-47. PMID 25374103 DOI: 10.3233/Jad-142094  0.84
2015 Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, ... ... Hyman BT, et al. At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 70-98. PMID 25022540 DOI: 10.1016/J.Jalz.2014.04.514  0.354
2015 Silvestri L, Rudinskiy N, Paciscopi M, Müllenbroich MC, Costantini I, Sacconi L, Frasconi P, Hyman BT, Pavone FS. Brain-wide charting of neuronal activation maps with cellular resolution Optics and the Brain, Brain 2015. DOI: 10.1364/Brain.2015.Brm3B.6  0.315
2015 Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... ... Hyman BT, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease Brain. 138: 2659-2671. DOI: 10.1093/brain/awv202  0.624
2015 Toledo JB, Zetterberg H, Van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, ... ... Hyman BT, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects Brain. 138: 2701-2715. DOI: 10.1093/brain/awv199  0.322
2015 Hudry EM, Martin C, Mu D, Mingozzi F, Hyman BT, Maguire CA. 312. Highly-Efficient CNS Transduction With Vesicle-Associated AAV Vector Molecular Therapy. 23: S126. DOI: 10.1016/S1525-0016(16)33921-1  0.31
2015 Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. O4-01-04: Entorhinal, parahippocampal, and inferior temporal F18-T807 SUVR correlates with CSF total tau and tau T181P in cognitively normal elderly Alzheimer's & Dementia. 11: P267-P267. DOI: 10.1016/J.Jalz.2015.07.348  0.325
2015 Hyman BT. S4-02-02: Modeling braak-like progression of tangles in the medial temporal lobe Alzheimer's & Dementia. 11: P258-P258. DOI: 10.1016/J.Jalz.2015.07.326  0.303
2015 Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe AD, Fan Z, Nicholls SB, DeVos SL, Takeda S, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler A, Hyman BT. O2-06-01: Lack of endogenous tau permits tau spreading and protects against tau toxicity in transgenic mice Alzheimer's & Dementia. 11: P186-P186. DOI: 10.1016/J.Jalz.2015.07.159  0.813
2015 Takeda S, Commins C, Wegmann S, Roe AD, Fan Z, DeVos SL, Costantino I, Trisini Lipsanopoulos A, Frosch MP, Hyman BT. P3-071: A unique high-molecular-weight tau species is involved in propagation and accumulates in the cerebrospinal fluid of Alzheimer's disease patients Alzheimer's & Dementia. 11: P644-P644. DOI: 10.1016/J.Jalz.2015.06.938  0.76
2015 Fol R, Hudry E, Audrain M, Burlot M, Dufayet-Chaffaud G, Bemelmans A, Hyman BT, Cartier N, Braudeau J. Improved amyloid pathology contrasting with unexpected memory defects following astrocytic ApoE-e2 overexpression in hippocampus of Alzheimer’s mice Alzheimers & Dementia. 11: 347. DOI: 10.1016/J.Jalz.2015.06.223  0.355
2015 Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NHH, Hsiung GYR, Hyman B, Iqbal K, Kaeser SA, Lachno DR, et al. Erratum: CSF biomarker variability in the Alzheimer's Association quality control program (Alzheimer's and Dementia (2013) 9 (251-261)) Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2014.12.004  0.386
2014 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, ... Hyman BT, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathologica. 128: 755-66. PMID 25348064 DOI: 10.1007/S00401-014-1349-0  0.766
2014 Tai HC, Wang BY, Serrano-Pozo A, Frosch MP, Spires-Jones TL, Hyman BT. Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease. Acta Neuropathologica Communications. 2: 146. PMID 25330988 DOI: 10.1186/S40478-014-0146-2  0.76
2014 Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ, Cooper JD, et al. Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathologica Communications. 2: 133. PMID 25200117 DOI: 10.1186/S40478-014-0133-7  0.592
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Hyman BT, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.648
2014 Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Kamboh MI, ... ... Hyman BT, et al. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. Plos Genetics. 10: e1004606. PMID 25188341 DOI: 10.1371/Journal.Pgen.1004606  0.618
2014 Hyman BT. Tau propagation, different tau phenotypes, and prion-like properties of tau. Neuron. 82: 1189-90. PMID 24945760 DOI: 10.1016/J.Neuron.2014.06.004  0.463
2014 Rudinskiy N, Hawkes JM, Wegmann S, Kuchibhotla KV, Muzikansky A, Betensky RA, Spires-Jones TL, Hyman BT. Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses. Acta Neuropathologica Communications. 2: 63. PMID 24915991 DOI: 10.1186/2051-5960-2-63  0.799
2014 Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic (Copenhagen, Denmark). 15: 819-38. PMID 24891099 DOI: 10.1111/Tra.12178  0.544
2014 Spires-Jones TL, Hyman BT. The intersection of amyloid beta and tau at synapses in Alzheimer's disease. Neuron. 82: 756-71. PMID 24853936 DOI: 10.1016/J.Neuron.2014.05.004  0.704
2014 Liao F, Hori Y, Hudry E, Bauer AQ, Jiang H, Mahan TE, Lefton KB, Zhang TJ, Dearborn JT, Kim J, Culver JP, Betensky R, Wozniak DF, Hyman BT, Holtzman DM. Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7281-92. PMID 24849360 DOI: 10.1523/Jneurosci.0646-14.2014  0.68
2014 Bit-Ivan EN, Suh E, Shim HS, Weintraub S, Hyman BT, Arnold SE, McCarty-Wood E, Van Deerlin VM, Schneider JA, Trojanowski JQ, Frosch MP, Baker MC, Rademakers R, Mesulam M, Bigio EH. A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases. Journal of Neuropathology and Experimental Neurology. 73: 467-73. PMID 24709683 DOI: 10.1097/Nen.0000000000000070  0.515
2014 Donovan NJ, Amariglio RE, Zoller AS, Rudel RK, Gomez-Isla T, Blacker D, Hyman BT, Locascio JJ, Johnson KA, Sperling RA, Marshall GA, Rentz DM. Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 22: 1642-51. PMID 24698445 DOI: 10.1016/J.Jagp.2014.02.007  0.384
2014 Marshall GA, Lorius N, Locascio JJ, Hyman BT, Rentz DM, Johnson KA, Sperling RA. Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum. Journal of Alzheimer's Disease : Jad. 41: 719-28. PMID 24685624 DOI: 10.3233/Jad-132768  0.352
2014 Dimant H, Zhu L, Kibuuka LN, Fan Z, Hyman BT, McLean PJ. Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics. Plos One. 9: e92098. PMID 24664141 DOI: 10.1371/Journal.Pone.0092098  0.812
2014 Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT. RNA aptamer probes as optical imaging agents for the detection of amyloid plaques. Plos One. 9: e89901. PMID 24587111 DOI: 10.1371/Journal.Pone.0089901  0.618
2014 Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gómez-Isla T, Betensky RA, Growdon JH, Johnson KA, Frosch MP, Sperling RA, Hyman BT. Mild to moderate Alzheimer dementia with insufficient neuropathological changes. Annals of Neurology. 75: 597-601. PMID 24585367 DOI: 10.1002/Ana.24125  0.819
2014 Spires-Jones TL, Friedman T, Pitstick R, Polydoro M, Roe A, Carlson GA, Hyman BT. Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neuroscience Letters. 562: 63-8. PMID 24462887 DOI: 10.1016/J.Neulet.2014.01.013  0.846
2014 Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. The role of clusterin in amyloid-β-associated neurodegeneration. Jama Neurology. 71: 180-7. PMID 24378367 DOI: 10.1001/Jamaneurol.2013.4560  0.409
2014 Kuchibhotla KV, Wegmann S, Kopeikina KJ, Hawkes J, Rudinskiy N, Andermann ML, Spires-Jones TL, Bacskai BJ, Hyman BT. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 510-4. PMID 24368848 DOI: 10.1073/Pnas.1318807111  0.85
2014 Growdon JH, Hyman BT. APOE genotype and brain development. Jama Neurology. 71: 7-8. PMID 24276019 DOI: 10.1001/Jamaneurol.2013.5200  0.614
2014 Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathologica. 127: 257-70. PMID 24271788 DOI: 10.1007/S00401-013-1215-5  0.844
2014 Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993). 22: 125-35. PMID 24210759 DOI: 10.1016/J.Str.2013.09.018  0.448
2014 Ren Y, Lin WL, Sanchez L, Ceballos C, Polydoro M, Spires-Jones TL, Hyman BT, Dickson DW, Sahara N. Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau. Journal of Alzheimer's Disease : Jad. 38: 589-600. PMID 24028867 DOI: 10.3233/Jad-130986  0.829
2014 Johnson KA, Mormino E, Rentz DM, Schultz A, Becker JA, Sepulcre J, Chhatwal J, Amariglio R, Papp K, Marshall G, Shoup T, Yokell D, Brady T, Hyman B, Vasdev N, et al. DT-01-02: TEMPORAL NEOCORTICAL TAU DEPOSITION MEASURED WITH PET IS ASSOCIATED WITH LONGITUDINAL DECLINE IN MEMORY PERFORMANCE AMONG CLINICALLY NORMAL ELDERLY Alzheimer's & Dementia. 10: P280-P280. DOI: 10.1016/J.Jalz.2014.07.150  0.426
2014 Fol RR, Hudry E, Audrain M, Burlot M, Dufayet-Chaffaud G, Bemelmans AP, Hyman BT, Cartier N, Braudeau J. Consequences Of Apoe2 Overexpression In Astrocytes In An Alzheimer'S Disease Mouse Model Alzheimers & Dementia. 10: 313. DOI: 10.1016/J.Jalz.2014.05.260  0.446
2014 Hudry E, Kuchibhotla K, Wrobleski L, Wegmann S, Arbel-Ornath M, Hyman B. O4-09-04: UNRAVELING THE ROLE OF APOLIPOPROTEIN E IN AGE- AND ABETA-RELATED NEURONAL DYSFUNCTION Alzheimer's & Dementia. 10: P269-P269. DOI: 10.1016/J.Jalz.2014.04.436  0.675
2013 Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. Plos One. 8: e80834. PMID 24278327 DOI: 10.1371/Journal.Pone.0080834  0.822
2013 Hudry E, Dashkoff J, Roe AD, Takeda S, Koffie RM, Hashimoto T, Scheel M, Spires-Jones T, Arbel-Ornath M, Betensky R, Davidson BL, Hyman BT. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Science Translational Medicine. 5: 212ra161. PMID 24259049 DOI: 10.1126/Scitranslmed.3007000  0.836
2013 Dimant H, Kalia SK, Kalia LV, Zhu LN, Kibuuka L, Ebrahimi-Fakhari D, McFarland NR, Fan Z, Hyman BT, McLean PJ. Direct detection of alpha synuclein oligomers in vivo. Acta Neuropathologica Communications. 1: 6. PMID 24252244 DOI: 10.1186/2051-5960-1-6  0.8
2013 Serrano-Pozo A, Qian J, Monsell SE, Frosch MP, Betensky RA, Hyman BT. Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. Journal of Neuropathology and Experimental Neurology. 72: 1182-92. PMID 24226270 DOI: 10.1097/Nen.0000000000000016  0.789
2013 Pooler AM, Polydoro M, Wegmann S, Nicholls SB, Spires-Jones TL, Hyman BT. Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets. Alzheimer's Research & Therapy. 5: 49. PMID 24152385 DOI: 10.1186/Alzrt214  0.861
2013 Santiago JA, Scherzer CR, Potashkin JA, Hyman BT, Ivinson AJ, Trisini-Lipsanopoulos A, Dhima K, Bayer S, Lockhart KC, Yi T, Liao Z, Hoesing AN, Duong K, Roderick S, Sudarsky LR, et al. Specific splice variants are associated with Parkinson's disease Movement Disorders. 28: 1724-1727. PMID 24108702 DOI: 10.1002/mds.25635  0.726
2013 Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration. Molecular Neurodegeneration. 8: 39. PMID 24088526 DOI: 10.1186/1750-1326-8-39  0.445
2013 Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, ... ... Hyman BT, et al. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 81: 1531-7. PMID 24068787 DOI: 10.1212/Wnl.0B013E3182A95818  0.61
2013 Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, Hyman BT, Shatz CJ. Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science (New York, N.Y.). 341: 1399-404. PMID 24052308 DOI: 10.1126/Science.1242077  0.452
2013 Polydoro M, de Calignon A, Suárez-Calvet M, Sanchez L, Kay KR, Nicholls SB, Roe AD, Pitstick R, Carlson GA, Gómez-Isla T, Spires-Jones TL, Hyman BT. Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13300-11. PMID 23946388 DOI: 10.1523/Jneurosci.0881-13.2013  0.839
2013 Maguire CA, Crommentuijn MH, Mu D, Hudry E, Serrano-Pozo A, Hyman BT, Tannous BA. Mouse gender influences brain transduction by intravascularly administered AAV9. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1470-1. PMID 23903572 DOI: 10.1038/Mt.2013.95  0.69
2013 Herskovits AZ, Locascio JJ, Peskind ER, Li G, Hyman BT. A Luminex assay detects amyloid β oligomers in Alzheimer's disease cerebrospinal fluid. Plos One. 8: e67898. PMID 23844122 DOI: 10.1371/Journal.Pone.0067898  0.467
2013 Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. The Journal of Comparative Neurology. 521: 4236-48. PMID 23839581 DOI: 10.1002/Cne.23411  0.839
2013 Perez-Nievas BG, Stein TD, Tai HC, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M, Serrano-Pozo A, Frosch MP, Lowe V, Parisi JE, Petersen RC, ... ... Hyman BT, et al. Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain : a Journal of Neurology. 136: 2510-26. PMID 23824488 DOI: 10.1093/Brain/Awt171  0.825
2013 Kay KR, Smith C, Wright AK, Serrano-Pozo A, Pooler AM, Koffie R, Bastin ME, Bak TH, Abrahams S, Kopeikina KJ, McGuone D, Frosch MP, Gillingwater TH, Hyman BT, Spires-Jones TL. Studying synapses in human brain with array tomography and electron microscopy. Nature Protocols. 8: 1366-80. PMID 23787894 DOI: 10.1038/Nprot.2013.078  0.79
2013 McCarter JF, Liebscher S, Bachhuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M. Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathologica. 126: 179-88. PMID 23775142 DOI: 10.1007/S00401-013-1137-2  0.457
2013 Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation. Scientific Reports. 3: 1823. PMID 23665843 DOI: 10.1038/Srep01823  0.681
2013 Serrano-Pozo A, Muzikansky A, Gómez-Isla T, Growdon JH, Betensky RA, Frosch MP, Hyman BT. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 72: 462-71. PMID 23656989 DOI: 10.1097/Nen.0B013E3182933788  0.823
2013 Takeda S, Hashimoto T, Roe AD, Hori Y, Spires-Jones TL, Hyman BT. Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3239-48. PMID 23640054 DOI: 10.1096/Fj.13-229666  0.781
2013 Macklin EA, Blacker D, Hyman BT, Betensky RA. Improved design of prodromal Alzheimer's disease trials through cohort enrichment and surrogate endpoints. Journal of Alzheimer's Disease : Jad. 36: 475-86. PMID 23629586 DOI: 10.3233/Jad-122212  0.388
2013 Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 78: 631-43. PMID 23623698 DOI: 10.1016/J.Neuron.2013.04.014  0.723
2013 Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, et al. CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 251-61. PMID 23622690 DOI: 10.1016/J.Jalz.2013.01.010  0.405
2013 Serrano-Pozo A, Gómez-Isla T, Growdon JH, Frosch MP, Hyman BT. A phenotypic change but not proliferation underlies glial responses in Alzheimer disease. The American Journal of Pathology. 182: 2332-44. PMID 23602650 DOI: 10.1016/J.Ajpath.2013.02.031  0.82
2013 Walker LC, Diamond MI, Duff KE, Hyman BT. Mechanisms of protein seeding in neurodegenerative diseases. Jama Neurology. 70: 304-10. PMID 23599928 DOI: 10.1001/Jamaneurol.2013.1453  0.457
2013 Wahler A, Beyer AS, Keller IE, Schnack C, von Einem B, Pröpper C, Boeckers TM, Peltan ID, Strickland DK, Hyman BT, von Arnim CA. Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1). The Biochemical Journal. 450: 333-43. PMID 23167255 DOI: 10.1042/Bj20121100  0.346
2013 Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions. Neurobiology of Disease. 50: 127-34. PMID 23064434 DOI: 10.1016/J.Nbd.2012.10.002  0.682
2013 Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL. Synaptic alterations in the rTg4510 mouse model of tauopathy. The Journal of Comparative Neurology. 521: 1334-53. PMID 23047530 DOI: 10.1002/Cne.23234  0.823
2013 Desikan RS, McEvoy LK, Holland D, Thompson WK, Brewer JB, Aisen PS, Andreassen OA, Hyman BT, Sperling RA, Dale AM. Apolipoprotein E epsilon4 does not modulate amyloid-β-associated neurodegeneration in preclinical Alzheimer disease. Ajnr. American Journal of Neuroradiology. 34: 505-10. PMID 22976236 DOI: 10.3174/Ajnr.A3267  0.41
2013 Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Constructs used in this study and complementation results. Plos One. DOI: 10.1371/Journal.Pone.0001867.T001  0.686
2013 Okereke O, O'Brien J, Rentz D, Hyman B, Blacker D. P2-263: Planning large-scale Alzheimer's disease questionnaire-aided studies (PLAQUES): Concordance of remote assessment methods with in-person diagnosis Alzheimer's & Dementia. 9: P454-P454. DOI: 10.1016/J.Jalz.2013.05.910  0.337
2013 Bachhuber T, McCarter J, Tahirovic S, Nuscher B, Kamp F, Abou-Ajram C, Serrano-Pozo A, Hyman B, Haass C, Meyer-Luehmann M. Cross-inhibition of beta-amyloid plaque formation by alpha-synuclein Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.1398  0.714
2013 Polydoro M, Hudry E, Perez-Nievas B, Arbel-Ornath M, Sanchez L, Spires-Jones T, Reumers V, Gómez-Isla T, Hyman B. P3-048: Caspase cleavage of tau is critical for oligomeric beta-amyloid-induced sub-lethal apoptotic cascade Alzheimer's & Dementia. 9: P568-P569. DOI: 10.1016/J.Jalz.2013.05.1117  0.791
2013 Kuchibhotla K, Wegmann S, Spires-Jones T, Bacskai B, Hyman B. O2-01-01: Neurofibrillary tangles remain functionally integrated in cortical networks Alzheimer's & Dementia. 9: P314-P314. DOI: 10.1016/J.Jalz.2013.04.135  0.767
2013 Hudry E, Arbel-Ornath M, Hashimoto T, Boivin J, Lattarulo C, Bacskai B, Hyman B. O1-01-03: Oligomeric soluble beta-amyloid species induce calcium dyshomeostasis in the healthy living mouse brain Alzheimer's & Dementia. 9: P126-P126. DOI: 10.1016/J.Jalz.2013.04.051  0.708
2012 Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15181-92. PMID 23100439 DOI: 10.1523/Jneurosci.1542-12.2012  0.836
2012 Kopeikina KJ, Hyman BT, Spires-Jones TL. Soluble forms of tau are toxic in Alzheimer's disease. Translational Neuroscience. 3: 223-233. PMID 23029602 DOI: 10.2478/S13380-012-0032-Y  0.855
2012 Rudinskiy N, Hawkes JM, Betensky RA, Eguchi M, Yamaguchi S, Spires-Jones TL, Hyman BT. Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease. Nature Neuroscience. 15: 1422-9. PMID 22922786 DOI: 10.1038/Nn.3199  0.64
2012 Cao L, Schrank BR, Rodriguez S, Benz EG, Moulia TW, Rickenbacher GT, Gomez AC, Levites Y, Edwards SR, Golde TE, Hyman BT, Barnea G, Albers MW. Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo. Nature Communications. 3: 1009. PMID 22910355 DOI: 10.1038/Ncomms2013  0.401
2012 Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. The American Journal of Pathology. 181: 1426-35. PMID 22867711 DOI: 10.1016/J.Ajpath.2012.06.033  0.844
2012 Serrano-Pozo A, Mielke ML, Muzitansky A, Gómez-Isla T, Growdon JH, Bacskai BJ, Betensky RA, Frosch MP, Hyman BT. Stable size distribution of amyloid plaques over the course of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 71: 694-701. PMID 22805771 DOI: 10.1097/Nen.0B013E31825E77De  0.83
2012 Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Hyman BT, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801  0.606
2012 William CM, Andermann ML, Goldey GJ, Roumis DK, Reid RC, Shatz CJ, Albers MW, Frosch MP, Hyman BT. Synaptic plasticity defect following visual deprivation in Alzheimer's disease model transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8004-11. PMID 22674275 DOI: 10.1523/JNEUROSCI.5369-11.2012  0.543
2012 Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlötzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, Winkler J. Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy. 8: 754-66. PMID 22647715 DOI: 10.4161/Auto.19371  0.775
2012 Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain : a Journal of Neurology. 135: 2155-68. PMID 22637583 DOI: 10.1093/Brain/Aws127  0.834
2012 Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5298-309. PMID 22496575 DOI: 10.1523/Jneurosci.0227-12.2012  0.738
2012 Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, ... Hyman BT, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/Nen.0B013E31825018F7  0.72
2012 Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3176-92. PMID 22378890 DOI: 10.1523/Jneurosci.6439-11.2012  0.819
2012 de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 73: 685-97. PMID 22365544 DOI: 10.1016/J.Neuron.2011.11.033  0.843
2012 Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 1-13. PMID 22265587 DOI: 10.1016/J.Jalz.2011.10.007  0.644
2012 Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, et al. Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. 39: 209-19. PMID 22218879 DOI: 10.1007/S00259-011-2045-0  0.401
2012 Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, ... Hyman BT, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathologica. 123: 1-11. PMID 22101365 DOI: 10.1007/S00401-011-0910-3  0.638
2012 Okereke OI, Pantoja-Galicia N, Copeland M, Hyman BT, Wanggaard T, Albert MS, Betensky RA, Blacker D. The SIST-M: predictive validity of a brief structured clinical dementia rating interview. Alzheimer Disease and Associated Disorders. 26: 225-31. PMID 21986342 DOI: 10.1097/Wad.0B013E318231Cd30  0.307
2012 DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, Rodríguez M, Sánchez MB, Hyman BT, Gómez-Isla T. Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease. Neurobiology of Disease. 45: 425-37. PMID 21945540 DOI: 10.1016/J.Nbd.2011.09.002  0.713
2012 Beyer AS, von Einem B, Schwanzar D, Keller IE, Hellrung A, Thal DR, Ingelsson M, Makarova A, Deng M, Chhabra ES, Pröpper C, Böckers TM, Hyman BT, von Arnim CA. Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein. Neurobiology of Aging. 33: 732-43. PMID 20674096 DOI: 10.1016/J.Neurobiolaging.2010.06.006  0.396
2012 de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of Tau Pathology in a Model of Early Alzheimer's Disease Neuron. 76: 461. DOI: 10.1016/j.neuron.2012.10.005  0.656
2012 Desikan R, McEvoy L, Schork A, Thompson W, Brewer J, Van De Bunt M, Morris A, McCarthy M, Owen M, O'Donovan M, Williams J, Hyman B, Andreassen O, Dale A. O1-09-05: On genetic pleiotropy between Alzheimer's disease and cardiovascular risk factors Alzheimer's & Dementia. 8: P101-P102. DOI: 10.1016/J.Jalz.2012.05.255  0.321
2011 Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT. Neuropathological alterations in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 1: a006189. PMID 22229116 DOI: 10.1101/Cshperspect.A006189  0.814
2011 Koffie RM, Farrar CT, Saidi LJ, William CM, Hyman BT, Spires-Jones TL. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proceedings of the National Academy of Sciences of the United States of America. 108: 18837-42. PMID 22065785 DOI: 10.1073/Pnas.1111405108  0.784
2011 Desikan RS, McEvoy LK, Thompson WK, Holland D, Roddey JC, Blennow K, Aisen PS, Brewer JB, Hyman BT, Dale AM. Amyloid-β associated volume loss occurs only in the presence of phospho-tau. Annals of Neurology. 70: 657-61. PMID 22002658 DOI: 10.1002/Ana.22509  0.437
2011 Ebrahimi-Fakhari D, Cantuti-Castelvetri I, Fan Z, Rockenstein E, Masliah E, Hyman BT, McLean PJ, Unni VK. Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14508-20. PMID 21994367 DOI: 10.1523/Jneurosci.1560-11.2011  0.815
2011 Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, ... ... Hyman BT, et al. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2283-6. PMID 21953863 DOI: 10.1002/Mds.23934  0.801
2011 Koffie RM, Hyman BT, Spires-Jones TL. Alzheimer's disease: synapses gone cold. Molecular Neurodegeneration. 6: 63. PMID 21871088 DOI: 10.1186/1750-1326-6-63  0.836
2011 Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Peters A, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. The American Journal of Pathology. 179: 2071-82. PMID 21854751 DOI: 10.1016/J.Ajpath.2011.07.004  0.838
2011 Ranganathan S, Noyes NC, Migliorini M, Winkles JA, Battey FD, Hyman BT, Smith E, Yepes M, Mikhailenko I, Strickland DK. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10836-46. PMID 21795536 DOI: 10.1523/Jneurosci.5065-10.2011  0.366
2011 Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, ... ... Hyman BT, et al. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 386-395.e6. PMID 21784349 DOI: 10.1016/J.Jalz.2011.05.2243  0.404
2011 Sperling RA, Jack CR, Black SE, Frosch MP, Greenberg SM, Hyman BT, Scheltens P, Carrillo MC, Thies W, Bednar MM, Black RS, Brashear HR, Grundman M, Siemers ER, Feldman HH, et al. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 367-85. PMID 21784348 DOI: 10.1016/J.Jalz.2011.05.2351  0.61
2011 Serrano-Pozo A, Mielke ML, Gómez-Isla T, Betensky RA, Growdon JH, Frosch MP, Hyman BT. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease. The American Journal of Pathology. 179: 1373-84. PMID 21777559 DOI: 10.1016/J.Ajpath.2011.05.047  0.837
2011 Growdon JH, Hyman BT. Plasma beta-amyloid linked to cognitive decline. Archives of Neurology. 68: 799-801. PMID 21670404 DOI: 10.1001/Archneurol.2011.114  0.503
2011 Fox LM, William CM, Adamowicz DH, Pitstick R, Carlson GA, Spires-Jones TL, Hyman BT. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. Journal of Neuropathology and Experimental Neurology. 70: 588-95. PMID 21666499 DOI: 10.1097/Nen.0B013E318220A658  0.669
2011 Hashimoto T, Adams KW, Fan Z, McLean PJ, Hyman BT. Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay. The Journal of Biological Chemistry. 286: 27081-91. PMID 21652708 DOI: 10.1074/Jbc.M111.257378  0.841
2011 Spires-Jones TL, Kopeikina KJ, Koffie RM, de Calignon A, Hyman BT. Are tangles as toxic as they look? Journal of Molecular Neuroscience : Mn. 45: 438-44. PMID 21638071 DOI: 10.1007/S12031-011-9566-7  0.845
2011 McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 263-9. PMID 21514250 DOI: 10.1016/J.Jalz.2011.03.005  0.433
2011 Dickerson BC, Stoub TR, Shah RC, Sperling RA, Killiany RJ, Albert MS, Hyman BT, Blacker D, Detoledo-Morrell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology. 76: 1395-402. PMID 21490323 DOI: 10.1212/Wnl.0B013E3182166E96  0.425
2011 DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T. Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. Journal of Neuropathology and Experimental Neurology. 70: 360-76. PMID 21487307 DOI: 10.1097/Nen.0B013E318217A118  0.829
2011 Hyman BT. Amyloid-dependent and amyloid-independent stages of Alzheimer disease. Archives of Neurology. 68: 1062-4. PMID 21482918 DOI: 10.1001/Archneurol.2011.70  0.492
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Hyman BT, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801  0.597
2011 Okereke OI, Copeland M, Hyman BT, Wanggaard T, Albert MS, Blacker D. The Structured Interview & Scoring Tool-Massachusetts Alzheimer's Disease Research Center (SIST-M): development, reliability, and cross-sectional validation of a brief structured clinical dementia rating interview. Archives of Neurology. 68: 343-50. PMID 21403019 DOI: 10.1001/Archneurol.2010.375  0.3
2011 Meyer-Luehmann M, Mora JR, Mielke M, Spires-Jones TL, de Calignon A, von Andrian UH, Hyman BT. T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice. Molecular Neurodegeneration. 6: 22. PMID 21388539 DOI: 10.1186/1750-1326-6-22  0.596
2011 Kalia LV, Kalia SK, Chau H, Lozano AM, Hyman BT, McLean PJ. Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). Plos One. 6: e14695. PMID 21358815 DOI: 10.1371/Journal.Pone.0014695  0.803
2011 Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. Plos One. 6: e14586. PMID 21297948 DOI: 10.1371/Journal.Pone.0014586  0.812
2011 Hyman BT. Caspase activation without apoptosis: insight into Aβ initiation of neurodegeneration. Nature Neuroscience. 14: 5-6. PMID 21187847 DOI: 10.1038/Nn0111-5  0.337
2011 Unni VK, Ebrahimi-Fakhari D, Vanderburg CR, McLean PJ, Hyman BT. Studying protein degradation pathways in vivo using a cranial window-based approach. Methods (San Diego, Calif.). 53: 194-200. PMID 21187150 DOI: 10.1016/J.Ymeth.2010.12.032  0.811
2011 Spires-Jones TL, de Calignon A, Meyer-Luehmann M, Bacskai BJ, Hyman BT. Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods (San Diego, Calif.). 53: 201-7. PMID 21163350 DOI: 10.1016/J.Ymeth.2010.12.009  0.781
2011 Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, et al. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic (Copenhagen, Denmark). 12: 330-48. PMID 21143716 DOI: 10.1111/J.1600-0854.2010.01149.X  0.488
2011 Rozkalne A, Hyman BT, Spires-Jones TL. Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice. Neurobiology of Disease. 41: 650-4. PMID 21134458 DOI: 10.1016/J.Nbd.2010.11.014  0.639
2011 Skoglund L, Matsui T, Freeman SH, Wallin A, Blom ES, Frosch MP, Growdon JH, Hyman BT, Lannfelt L, Ingelsson M, Glaser A. Novel progranulin mutation detected in 2 patients with FTLD. Alzheimer Disease and Associated Disorders. 25: 173-8. PMID 20975516 DOI: 10.1097/Wad.0B013E3181Fbc22C  0.592
2011 Spires-Jones TL, Kay K, Matsouka R, Rozkalne A, Betensky RA, Hyman BT. Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain. Neuroscience Letters. 487: 260-3. PMID 20970476 DOI: 10.1016/J.Neulet.2010.10.033  0.599
2011 Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ. Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 326-36. PMID 20876215 DOI: 10.1096/Fj.10-164624  0.806
2011 Holtzman D, Hyman B, Lee V, Spires-Jones T, Koffie R, Hashimoto T, Joyner D, Hou S, Kopeikina K, Frosch M. O1-05-01: APOE4 plays a role in Abeta-mediated synapse loss in Alzheimer's disease Alzheimer's & Dementia. 7: S103-S104. DOI: 10.1016/J.Jalz.2011.05.256  0.821
2011 Wahlster L, Arimon M, Nasser-Ghodsi N, Serrano-Pozo A, Hyman B, Berezovska O. γ-Secretase conformational changes in the Alzheimer's Disease brain Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1636  0.742
2011 Hudry E, Hashimoto T, Scheel M, Dashkoff J, Spires-Jones T, Bacskai B, Davidson B, Hyman B. P2-465: Changes in the progression of amyloid deposition in APP/PS mice after overexpression of different ApoE isoforms through intraventricular injection of an adeno-associated virus serotype 4 Alzheimer's & Dementia. 7: S461-S462. DOI: 10.1016/J.Jalz.2011.05.1337  0.792
2011 Spires-Jones TL, Kopeikina KJ, Koffie RM, de Calignon A, Hyman BT. Erratum to: Are Tangles as Toxic as They Look? Journal of Molecular Neuroscience. 45: 742-742. DOI: 10.1007/S12031-011-9581-8  0.79
2010 Blom ES, Wang Y, Skoglund L, Hansson AC, Ubaldi M, Lourdusamy A, Sommer WH, Mielke M, Hyman BT, Heilig M, Lannfelt L, Nilsson LN, Ingelsson M. Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain. International Journal of Alzheimer's Disease. 2011: 936580. PMID 21234373 DOI: 10.4061/2011/936580  0.411
2010 Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nature Communications. 1: 130. PMID 21119643 DOI: 10.1038/Ncomms1129  0.616
2010 de Calignon A, Spires-Jones TL, Hyman BT. [Caspase activation precedes and leads to neurodegeneration in a murine model of Alzheimer's disease]. Mã©Decine Sciences : M/S. 26: 787-9. PMID 20929661 DOI: 10.1051/Medsci/20102610787  0.648
2010 Unni VK, Weissman TA, Rockenstein E, Masliah E, McLean PJ, Hyman BT. In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility. Plos One. 5: e10589. PMID 20485674 DOI: 10.1371/Journal.Pone.0010589  0.807
2010 Serrano-Pozo A, Vega GL, Lütjohann D, Locascio JJ, Tennis MK, Deng A, Atri A, Hyman BT, Irizarry MC, Growdon JH. Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers. Alzheimer Disease and Associated Disorders. 24: 220-6. PMID 20473136 DOI: 10.1097/Wad.0B013E3181D61Fea  0.789
2010 Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, Hock C, Nitsch RM, Masliah E, Growdon JH, Frosch MP, Hyman BT. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain : a Journal of Neurology. 133: 1312-27. PMID 20360050 DOI: 10.1093/Brain/Awq056  0.818
2010 de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT. Caspase activation precedes and leads to tangles. Nature. 464: 1201-4. PMID 20357768 DOI: 10.1038/Nature08890  0.765
2010 Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. Plos One. 5: e9505. PMID 20209079 DOI: 10.1371/Journal.Pone.0009505  0.458
2010 Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2636-49. PMID 20164348 DOI: 10.1523/Jneurosci.4456-09.2010  0.824
2010 Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, Rodríguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, ... Hyman BT, et al. Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiology of Disease. 38: 482-91. PMID 20149872 DOI: 10.1016/J.Nbd.2010.01.019  0.649
2010 Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ. Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity. The Journal of Pharmacology and Experimental Therapeutics. 332: 849-57. PMID 19934398 DOI: 10.1124/Jpet.109.158436  0.804
2010 Hillmer AS, Putcha P, Levin J, Högen T, Hyman BT, Kretzschmar H, McLean PJ, Giese A. Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron. Biochemical and Biophysical Research Communications. 391: 461-6. PMID 19914207 DOI: 10.1016/J.Bbrc.2009.11.080  0.753
2010 Fukumoto N, Fujii T, Combarros O, Kamboh MI, Tsai SJ, Matsushita S, Nacmias B, Comings DE, Arboleda H, Ingelsson M, Hyman BT, Akatsu H, Grupe A, Nishimura AL, Zatz M, et al. Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 235-42. PMID 19504537 DOI: 10.1002/Ajmg.B.30986  0.361
2010 Garcia-Alloza M, Borrelli LA, Hyman BT, Bacskai BJ. Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. Neurobiology of Aging. 31: 2058-68. PMID 19124175 DOI: 10.1016/J.Neurobiolaging.2008.11.006  0.638
2010 Hyman BT, de Calignon A, Suarez-Calvet M, William C, Pitstick R, Carlson GA, Spires-Jones TL. PL-05-01: A transgenic model of the earliest stage of Alzheimer's disease Alzheimer's & Dementia. 6: S165-S165. DOI: 10.1016/J.Jalz.2010.05.513  0.64
2010 Bacskai BJ, Kuchibhotla KV, Lattarulo C, Hyman BT. Dysregulation of Intracellular Calcium in Alzheimer's Disease Biophysical Journal. 98: 3a. DOI: 10.1016/J.Bpj.2009.12.015  0.606
2009 Skoglund L, Ingvast S, Matsui T, Freeman SH, Frosch MP, Brundin R, Giedraitis V, Growdon JH, Hyman BT, Lannfelt L, Ingelsson M, Glaser A. No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration. Dementia and Geriatric Cognitive Disorders. 28: 471-5. PMID 19940479 DOI: 10.1159/000260046  0.653
2009 Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. Plos One. 4: e7893. PMID 19924286 DOI: 10.1371/Journal.Pone.0007893  0.612
2009 Chen L, Periquet M, Wang X, Negro A, McLean PJ, Hyman BT, Feany MB. Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. The Journal of Clinical Investigation. 119: 3257-65. PMID 19855133 DOI: 10.1172/Jci39088  0.753
2009 Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT. A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12636-40. PMID 19812338 DOI: 10.1523/Jneurosci.1948-09.2009  0.721
2009 Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT. Dopamine-induced conformational changes in alpha-synuclein. Plos One. 4: e6906. PMID 19730729 DOI: 10.1371/Journal.Pone.0006906  0.798
2009 Stoothoff W, Jones PB, Spires-Jones TL, Joyner D, Chhabra E, Bercury K, Fan Z, Xie H, Bacskai B, Edd J, Irimia D, Hyman BT. Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. Journal of Neurochemistry. 111: 417-27. PMID 19686388 DOI: 10.1111/J.1471-4159.2009.06316.X  0.808
2009 Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 63: 178-88. PMID 19640477 DOI: 10.1016/J.Neuron.2009.07.003  0.44
2009 de Calignon A, Spires-Jones TL, Pitstick R, Carlson GA, Hyman BT. Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. Journal of Neuropathology and Experimental Neurology. 68: 757-61. PMID 19535996 DOI: 10.1097/Nen.0B013E3181A9Fc66  0.636
2009 McFarland NR, Fan Z, Xu K, Schwarzschild MA, Feany MB, Hyman BT, McLean PJ. Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. Journal of Neuropathology and Experimental Neurology. 68: 515-24. PMID 19525899 DOI: 10.1097/Nen.0B013E3181A24B53  0.802
2009 Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7459-73. PMID 19515914 DOI: 10.1523/Jneurosci.4872-08.2009  0.642
2009 Rozkalne A, Spires-Jones TL, Stern EA, Hyman BT. A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model. Brain Research. 1280: 178-85. PMID 19465012 DOI: 10.1016/J.Brainres.2009.05.045  0.693
2009 Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A. Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface. Journal of Neurochemistry. 110: 220-30. PMID 19457132 DOI: 10.1111/J.1471-4159.2009.06126.X  0.345
2009 Blom ES, Giedraitis V, Zetterberg H, Fukumoto H, Blennow K, Hyman BT, Irizarry MC, Wahlund LO, Lannfelt L, Ingelsson M. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. Dementia and Geriatric Cognitive Disorders. 27: 458-64. PMID 19420940 DOI: 10.1159/000216841  0.475
2009 Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Molecular Neurodegeneration. 4: 19. PMID 19419556 DOI: 10.1186/1750-1326-4-19  0.65
2009 Fischl B, Stevens AA, Rajendran N, Yeo BT, Greve DN, Van Leemput K, Polimeni JR, Kakunoori S, Buckner RL, Pacheco J, Salat DH, Melcher J, Frosch MP, Hyman BT, Grant PE, et al. Predicting the location of entorhinal cortex from MRI. Neuroimage. 47: 8-17. PMID 19376238 DOI: 10.1016/J.Neuroimage.2009.04.033  0.569
2009 Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, et al. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science (New York, N.Y.). 324: 639-42. PMID 19299585 DOI: 10.1126/Science.1171176  0.419
2009 Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. Molecular and Cellular Neurosciences. 41: 166-74. PMID 19281847 DOI: 10.1016/J.Mcn.2009.02.008  0.41
2009 Kuchibhotla KV, Lattarulo CR, Hyman BT, Bacskai BJ. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science (New York, N.Y.). 323: 1211-5. PMID 19251629 DOI: 10.1126/Science.1169096  0.624
2009 McFarland NR, Lee JS, Hyman BT, McLean PJ. Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system. Journal of Neurochemistry. 109: 838-45. PMID 19250335 DOI: 10.1111/J.1471-4159.2009.06010.X  0.802
2009 Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proceedings of the National Academy of Sciences of the United States of America. 106: 4012-7. PMID 19228947 DOI: 10.1073/Pnas.0811698106  0.827
2009 Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. Journal of Alzheimer's Disease : Jad. 16: 277-85. PMID 19221417 DOI: 10.3233/Jad-2009-0948  0.377
2009 Hoe HS, Fu Z, Makarova A, Lee JY, Lu C, Feng L, Pajoohesh-Ganji A, Matsuoka Y, Hyman BT, Ehlers MD, Vicini S, Pak DT, Rebeck GW. The effects of amyloid precursor protein on postsynaptic composition and activity. The Journal of Biological Chemistry. 284: 8495-506. PMID 19164281 DOI: 10.1074/Jbc.M900141200  0.615
2009 Spires-Jones TL, Stoothoff WH, de Calignon A, Jones PB, Hyman BT. Tau pathophysiology in neurodegeneration: a tangled issue. Trends in Neurosciences. 32: 150-9. PMID 19162340 DOI: 10.1016/J.Tins.2008.11.007  0.675
2009 Desikan RS, Cabral HJ, Fischl B, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease. Ajnr. American Journal of Neuroradiology. 30: 532-8. PMID 19112067 DOI: 10.3174/Ajnr.A1397  0.376
2009 Spoelgen R, Adams KW, Koker M, Thomas AV, Andersen OM, Hallett PJ, Bercury KK, Joyner DF, Deng M, Stoothoff WH, Strickland DK, Willnow TE, Hyman BT. Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Neuroscience. 158: 1460-8. PMID 19047013 DOI: 10.1016/J.Neuroscience.2008.10.061  0.779
2009 Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. Journal of Neurochemistry. 108: 350-60. PMID 19046403 DOI: 10.1111/J.1471-4159.2008.05760.X  0.359
2009 Spires-Jones TL, Mielke ML, Rozkalne A, Meyer-Luehmann M, de Calignon A, Bacskai BJ, Schenk D, Hyman BT. Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiology of Disease. 33: 213-20. PMID 19028582 DOI: 10.1016/J.Nbd.2008.10.011  0.762
2009 Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE. Effects of ubiquilin 1 on the unfolded protein response. Journal of Molecular Neuroscience : Mn. 38: 19-30. PMID 18953672 DOI: 10.1007/S12031-008-9155-6  0.366
2009 Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, Sperling RA, Atri A, Growdon JH, Hyman BT, Morris JC, et al. The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cerebral Cortex (New York, N.Y. : 1991). 19: 497-510. PMID 18632739 DOI: 10.1093/Cercor/Bhn113  0.597
2009 Freeman SH, Hyman BT, Sims KB, Hedley-Whyte ET, Vossough A, Frosch MP, Schmahmann JD. Adult onset leukodystrophy with neuroaxonal spheroids: clinical, neuroimaging and neuropathologic observations. Brain Pathology (Zurich, Switzerland). 19: 39-47. PMID 18422757 DOI: 10.1111/J.1750-3639.2008.00163.X  0.641
2009 Philipson O, Hammarström P, Nilsson KP, Portelius E, Olofsson T, Ingelsson M, Hyman BT, Blennow K, Lannfelt L, Kalimo H, Nilsson LN. A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice. Neurobiology of Aging. 30: 1393-405. PMID 18192084 DOI: 10.1016/J.Neurobiolaging.2007.11.022  0.438
2009 Jones PB, Bacskai BJ, Hyman BT. Chapter 11 Biomedical FRET-FLIM applications Laboratory Techniques in Biochemistry and Molecular Biology. 33: 447-474. DOI: 10.1016/S0075-7535(08)00011-9  0.412
2008 Stoothoff WH, Bacskai BJ, Hyman BT. Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons. Journal of Biomedical Optics. 13: 064039. PMID 19123685 DOI: 10.1117/1.3050422  0.624
2008 Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14156-64. PMID 19109498 DOI: 10.1523/Jneurosci.4147-08.2008  0.637
2008 Mandal AK, Jones PB, Bair AM, Christmas P, Miller D, Yamin TT, Wisniewski D, Menke J, Evans JF, Hyman BT, Bacskai B, Chen M, Lee DM, Nikolic B, Soberman RJ. The nuclear membrane organization of leukotriene synthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 20434-9. PMID 19075240 DOI: 10.1073/Pnas.0808211106  0.504
2008 Freeman SH, Kandel R, Cruz L, Rozkalne A, Newell K, Frosch MP, Hedley-Whyte ET, Locascio JJ, Lipsitz LA, Hyman BT. Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 67: 1205-12. PMID 19018241 DOI: 10.1097/Nen.0B013E31818Fc72F  0.689
2008 Grodstein F, van Oijen M, Irizarry MC, Rosas HD, Hyman BT, Growdon JH, De Vivo I. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. Plos One. 3: e1590. PMID 18795148 DOI: 10.1371/Journal.Pone.0001590  0.514
2008 Gomperts SN, Rentz DM, Moran E, Becker JA, Locascio JJ, Klunk WE, Mathis CA, Elmaleh DR, Shoup T, Fischman AJ, Hyman BT, Growdon JH, Johnson KA. Imaging amyloid deposition in Lewy body diseases. Neurology. 71: 903-10. PMID 18794492 DOI: 10.1212/01.Wnl.0000326146.60732.D6  0.618
2008 Hyman B. In reply to Zou et al. "New amyloid plaques or a game of hide-and-seek?". International Journal of Biological Sciences. 4: 245. PMID 18726000 DOI: 10.7150/Ijbs.4.245  0.315
2008 Desikan RS, Fischl B, Cabral HJ, Kemper TL, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD. Neurology. 71: 819-25. PMID 18672473 DOI: 10.1212/01.Wnl.0000320055.57329.34  0.368
2008 Kuchibhotla KV, Goldman ST, Lattarulo CR, Wu HY, Hyman BT, Bacskai BJ. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron. 59: 214-25. PMID 18667150 DOI: 10.1016/J.Neuron.2008.06.008  0.617
2008 Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, ... Hyman B, et al. A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 4: 156-63. PMID 18631960 DOI: 10.1016/J.Jalz.2008.03.005  0.367
2008 Gomez-Isla T, Spires T, De Calignon A, Hyman BT. Neuropathology of Alzheimer's disease. Handbook of Clinical Neurology. 89: 233-43. PMID 18631748 DOI: 10.1016/S0072-9752(07)01222-5  0.372
2008 Steinerman JR, Irizarry M, Scarmeas N, Raju S, Brandt J, Albert M, Blacker D, Hyman B, Stern Y. Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study. Archives of Neurology. 65: 906-12. PMID 18625856 DOI: 10.1001/Archneur.65.7.906  0.433
2008 Makarova A, Bercury KK, Adams KW, Joyner D, Deng M, Spoelgen R, Koker M, Strickland DK, Hyman BT. The LDL receptor-related protein can form homo-dimers in neuronal cells. Neuroscience Letters. 442: 91-5. PMID 18602448 DOI: 10.1016/J.Neulet.2008.06.070  0.78
2008 Locascio JJ, Fukumoto H, Yap L, Bottiglieri T, Growdon JH, Hyman BT, Irizarry MC. Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease. Archives of Neurology. 65: 776-85. PMID 18541797 DOI: 10.1001/Archneur.65.6.776  0.576
2008 Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. CHIP targets toxic alpha-Synuclein oligomers for degradation. The Journal of Biological Chemistry. 283: 17962-8. PMID 18436529 DOI: 10.1074/Jbc.M802283200  0.803
2008 O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X. Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells. Brain Pathology (Zurich, Switzerland). 18: 548-61. PMID 18422760 DOI: 10.1111/J.1750-3639.2008.00152.X  0.452
2008 Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Formation of toxic oligomeric alpha-synuclein species in living cells. Plos One. 3: e1867. PMID 18382657 DOI: 10.1371/Journal.Pone.0001867  0.795
2008 Thomas AV, Berezovska O, Hyman BT, von Arnim CA. Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells. Methods (San Diego, Calif.). 44: 299-303. PMID 18374273 DOI: 10.1016/J.Ymeth.2007.02.003  0.479
2008 Jones PB, Rozkalne A, Meyer-Luehmann M, Spires-Jones TL, Makarova A, Kumar AT, Berezovska O, Bacskai BB, Hyman BT. Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. Journal of Biomedical Optics. 13: 014008. PMID 18315366 DOI: 10.1117/1.2837169  0.606
2008 Sundelöf J, Giedraitis V, Irizarry MC, Sundström J, Ingelsson E, Rönnemaa E, Arnlöv J, Gunnarsson MD, Hyman BT, Basun H, Ingelsson M, Lannfelt L, Kilander L. Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study. Archives of Neurology. 65: 256-63. PMID 18268197 DOI: 10.1001/Archneurol.2007.57  0.45
2008 Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 451: 720-4. PMID 18256671 DOI: 10.1038/Nature06616  0.787
2008 Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 862-7. PMID 18216194 DOI: 10.1523/Jneurosci.3072-08.2008  0.712
2008 Yacoubian TA, Cantuti-Castelvetri I, Bouzou B, Asteris G, McLean PJ, Hyman BT, Standaert DG. Transcriptional dysregulation in a transgenic model of Parkinson disease. Neurobiology of Disease. 29: 515-28. PMID 18191405 DOI: 10.1016/J.Nbd.2007.11.008  0.739
2008 Freeman SH, Spires-Jones T, Hyman BT, Growdon JH, Frosch MP. TAR-DNA binding protein 43 in Pick disease. Journal of Neuropathology and Experimental Neurology. 67: 62-7. PMID 18091558 DOI: 10.1097/Nen.0B013E3181609361  0.776
2008 Hoe HS, Minami SS, Makarova A, Lee J, Hyman BT, Matsuoka Y, Rebeck GW. Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. The Journal of Biological Chemistry. 283: 6288-99. PMID 18089558 DOI: 10.1074/Jbc.M704140200  0.798
2008 Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells Plos One. 3. DOI: 10.1371/Annotation/9282F173-Df82-4B70-9120-B4E62B3Dacb1  0.775
2008 Freeman S, Kandel R, Cruz L, Rozkalne A, Newell K, Frosch MP, Hedley-Whyte ET, Lipsitz L, Hyman BT. P4-154: Neuronal atrophy and neuropil loss, rather than neuronal loss, underlies age-related cortical brain atrophy in elderly subjects without Alzheimer's disease Alzheimer's & Dementia. 4: T715-T715. DOI: 10.1016/J.Jalz.2008.05.2221  0.578
2008 Sundelöf JE, Ärnlöv J, Ingelsson E, Sundström J, Basu S, Zethelius B, Larsson A, Irizarry MC, Giedraitis V, Rönnemaa E, Degerman-Gunnarsson M, Hyman BT, Basun H, Kilander L, Lannfelt L. P4-108: Serum cystatin C and the risk of Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.2174  0.351
2008 Callaghan PO, Sandwall E, Li J, Yu H, Ravid R, Guan Z, Kuppevelt THv, Nilsson LNG, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X. P3-416: Aβ stimulation leads to elevated levels of heparan sulfate proteoglycans in glial cells Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1987  0.308
2008 Blom ES, Wang Y, Hansson A, Sommer W, Hyman BT, Heilig M, Lannfelt L, Nisson LNG, Ingelsson M. P3-205: Upregulation of genes in the Wnt pathway in tg-ArcSwe mice and Alzheimer's disease brain Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1772  0.397
2008 Ingelsson M, Blom E, Zetterberg H, Fukumoto H, Hyman BT, Irizarry MC, Blennow K, Wahlund L, Lannfelt L. P3-076: CSF Tau levels and APOEϵ4 carriership predict the progression of mild cognitive impairment to Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1640  0.4
2008 Kowa H, Matsui T, Bouzou B, Clark T, Freeman S, Frosch M, Hyman B. P2-194: Complement pathways are upregulated in angular gyrus of primary progressive aphasia cases Alzheimer's & Dementia. 4: T427-T428. DOI: 10.1016/J.Jalz.2008.05.1268  0.459
2008 de Calignon A, Spires-Jones T, Hyman BT. P2-164: In vivo multiphoton imaging of neurofibrillary tangles: Relationship to cell death cascades Alzheimer's & Dementia. 4: T418-T418. DOI: 10.1016/J.Jalz.2008.05.1238  0.569
2008 Meyer-Luehmann M, Stoothoff W, Spires-Jones TL, Kowa T, Koker M, Han K, Hyman BT. P1-486: Decreased neuronal activity in APP transgenic mice measured via dendritic protein synthesis Alzheimer's & Dementia. 4: T362-T362. DOI: 10.1016/J.Jalz.2008.05.1069  0.598
2008 Kuchibhotla KV, Goldman ST, Lattarulo CR, Hyman BT, Bacskai BJ. P1-473: Aβ disrupts spinodendritic calcium regulation in vivo Alzheimer's & Dementia. 4: T358-T358. DOI: 10.1016/J.Jalz.2008.05.1056  0.549
2007 Dickerson BC, Sperling RA, Hyman BT, Albert MS, Blacker D. Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment. Archives of General Psychiatry. 64: 1443-50. PMID 18056553 DOI: 10.1001/Archpsyc.64.12.1443  0.341
2007 Giedraitis V, Sundelöf J, Irizarry MC, GÃ¥revik N, Hyman BT, Wahlund LO, Ingelsson M, Lannfelt L. The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease. Neuroscience Letters. 427: 127-31. PMID 17936506 DOI: 10.1016/J.Neulet.2007.09.023  0.423
2007 Irizarry MC, Yao Y, Hyman BT, Growdon JH, Praticò D. Plasma F2A isoprostane levels in Alzheimer's and Parkinson's disease. Neuro-Degenerative Diseases. 4: 403-5. PMID 17934322 DOI: 10.1159/000107699  0.574
2007 Grammatopoulos TN, Outeiro TF, Hyman BT, Standaert DG. Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro. Biochemical and Biophysical Research Communications. 363: 846-51. PMID 17900533 DOI: 10.1016/J.Bbrc.2007.09.043  0.306
2007 Garcia-Alloza M, Ferrara BJ, Dodwell SA, Hickey GA, Hyman BT, Bacskai BJ. A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiology of Disease. 28: 286-92. PMID 17822910 DOI: 10.1016/J.Nbd.2007.07.019  0.634
2007 Beekly DL, Ramos EM, Lee WW, Deitrich WD, Jacka ME, Wu J, Hubbard JL, Koepsell TD, Morris JC, Kukull WA, Reiman EM, Kowall N, Landreth G, Shelanski M, Welsh-Bohmer K, ... ... Hyman B, et al. The National Alzheimer's Coordinating Center (NACC) database: The uniform data set Alzheimer Disease and Associated Disorders. 21: 249-258. PMID 17804958 DOI: 10.1097/Wad.0B013E318142774E  0.31
2007 Conrad C, Zhu J, Conrad C, Schoenfeld D, Fang Z, Ingelsson M, Stamm S, Church G, Hyman BT. Single molecule profiling of tau gene expression in Alzheimer's disease. Journal of Neurochemistry. 103: 1228-36. PMID 17727636 DOI: 10.1111/J.1471-4159.2007.04857.X  0.536
2007 Ingelsson M, Ramasamy K, Russ C, Freeman SH, Orne J, Raju S, Matsui T, Growdon JH, Frosch MP, Ghetti B, Brown RH, Irizarry MC, Hyman BT. Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains. Acta Neuropathologica. 114: 471-9. PMID 17721707 DOI: 10.1007/S00401-007-0280-Z  0.693
2007 Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT. Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. The American Journal of Pathology. 171: 1304-11. PMID 17717139 DOI: 10.2353/Ajpath.2007.070055  0.747
2007 Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain : a Journal of Neurology. 130: 2310-9. PMID 17638859 DOI: 10.1093/Brain/Awm156  0.694
2007 Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (New York, N.Y.). 317: 516-9. PMID 17588900 DOI: 10.1126/Science.1143780  0.747
2007 Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT. Expression of APP pathway mRNAs and proteins in Alzheimer's disease. Brain Research. 1161: 116-23. PMID 17586478 DOI: 10.1016/J.Brainres.2007.05.050  0.622
2007 Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Journal of Neurochemistry. 102: 1095-104. PMID 17472706 DOI: 10.1111/J.1471-4159.2007.04613.X  0.664
2007 Outeiro TF, Grammatopoulos TN, Altmann S, Amore A, Standaert DG, Hyman BT, Kazantsev AG. Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models. Biochemical and Biophysical Research Communications. 357: 596-602. PMID 17449015 DOI: 10.1016/J.Bbrc.2007.03.163  0.323
2007 Freeman SH, Raju S, Hyman BT, Frosch MP, Irizarry MC. Plasma Abeta levels do not reflect brain Abeta levels. Journal of Neuropathology and Experimental Neurology. 66: 264-71. PMID 17413317 DOI: 10.1097/Nen.0B013E31803D3Ae4  0.583
2007 Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Archives of Neurology. 64: 431-4. PMID 17353389 DOI: 10.1001/Archneur.64.3.431  0.751
2007 Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of Biological Chemistry. 282: 7825-32. PMID 17244626 DOI: 10.1074/Jbc.M609168200  0.391
2007 St Martin JL, Klucken J, Outeiro TF, Nguyen P, Keller-McGandy C, Cantuti-Castelvetri I, Grammatopoulos TN, Standaert DG, Hyman BT, McLean PJ. Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. Journal of Neurochemistry. 100: 1449-57. PMID 17241127 DOI: 10.1111/J.1471-4159.2006.04310.X  0.761
2007 Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature Cell Biology. 9: 139-48. PMID 17187063 DOI: 10.1038/Ncb1528  0.462
2007 Klucken J, McLean P, Hyman B, Bogdahn U, Winkler J. Chaperon Proteine steuern die alpha-Synuclein Aggregation und Degradation Aktuelle Neurologie. 34. DOI: 10.1055/S-2007-987900  0.732
2007 Meyer-Lühmann M, Hyman B, Jucker M. S.19.03 Exploring the early pathogenesis in Alzheimer's disease: insights from transgenic mouse models European Neuropsychopharmacology. 17: S205. DOI: 10.1016/S0924-977X(07)70249-3  0.302
2007 Desikan RS, Fischl B, Cabral HJ, Kemper TL, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. P-030: MRI-based longitudinal measures of temporoparietal regions show differential rates of atrophy during prodromal Alzheimer's disease Alzheimer's & Dementia. 3: S106-S106. DOI: 10.1016/J.Jalz.2007.04.246  0.36
2007 Outeiro TF, McLean PJ, Hyman BT. Protein aggregation disorders Neurobiology of Disease. 111-123. DOI: 10.1016/B978-012088592-3/50012-8  0.782
2006 Hyman BT. The natural history of Alzheimer disease dissected through multiphoton imaging of transgenic mice. Alzheimer Disease and Associated Disorders. 20: 206-9. PMID 17132963 DOI: 10.1097/01.Wad.0000213850.51495.0F  0.38
2006 Jones PB, Herl L, Berezovska O, Kumar AT, Bacskai BJ, Hyman BT. Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. Journal of Biomedical Optics. 11: 054024. PMID 17092173 DOI: 10.1117/1.2363367  0.562
2006 Garcia-Alloza M, Dodwell SA, Meyer-Luehmann M, Hyman BT, Bacskai BJ. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. Journal of Neuropathology and Experimental Neurology. 65: 1082-9. PMID 17086105 DOI: 10.1097/01.Jnen.0000240468.12543.Af  0.621
2006 Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ. Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Biochemical and Biophysical Research Communications. 351: 631-8. PMID 17081499 DOI: 10.1016/J.Bbrc.2006.10.085  0.763
2006 Klucken J, Outeiro TF, Nguyen P, McLean PJ, Hyman BT. Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2050-7. PMID 17012257 DOI: 10.1096/Fj.05-5422Com  0.729
2006 von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Lichtenthaler SF, Irizarry MC, Hyman BT. GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9913-22. PMID 17005855 DOI: 10.1523/Jneurosci.2290-06.2006  0.407
2006 Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ. Physical and functional connection between auxilin and dynamin during endocytosis. The Embo Journal. 25: 4163-74. PMID 16946707 DOI: 10.1038/Sj.Emboj.7601298  0.515
2006 Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. The Journal of Biological Chemistry. 281: 32240-53. PMID 16945923 DOI: 10.1074/Jbc.M603106200  0.441
2006 Peltan ID, Thomas AV, Mikhailenko I, Strickland DK, Hyman BT, von Arnim CA. Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons. Biochemical and Biophysical Research Communications. 349: 24-30. PMID 16930548 DOI: 10.1016/J.Bbrc.2006.07.212  0.33
2006 Skoch J, Hyman BT, Bacskai BJ. Preclinical characterization of amyloid imaging probes with multiphoton microscopy. Journal of Alzheimer's Disease : Jad. 9: 401-7. PMID 16914878 DOI: 10.3233/Jad-2006-9S345  0.606
2006 Hyman BT, Growdon JH. Can the immune system fight Alzheimer disease? Nature Medicine. 12: 755-6; discussion 75. PMID 16829929 DOI: 10.1038/Nm0706-755  0.548
2006 Thomas AV, Herl L, Spoelgen R, Hiltunen M, Jones PB, Tanzi RE, Hyman BT, Berezovska O. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. The Journal of Biological Chemistry. 281: 26400-7. PMID 16815845 DOI: 10.1074/Jbc.M601085200  0.424
2006 Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T, Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees AJ, Lannfelt L, Growdon JH, Frosch MP, ... ... Hyman BT, et al. No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain. Acta Neuropathologica. 112: 439-49. PMID 16802167 DOI: 10.1007/S00401-006-0095-3  0.717
2006 Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT. Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. Journal of Neuropathology and Experimental Neurology. 65: 508-15. PMID 16772874 DOI: 10.1097/01.Jnen.0000229238.05748.12  0.601
2006 Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT. Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. The American Journal of Pathology. 168: 1598-607. PMID 16651626 DOI: 10.2353/Ajpath.2006.050840  0.431
2006 Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proceedings of the National Academy of Sciences of the United States of America. 103: 4246-51. PMID 16537516 DOI: 10.1073/Pnas.0511256103  0.763
2006 Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, McKinstry WJ, Parker MW, Masters CL, Hyman BT, Cappai R, Willnow TE. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry. 45: 2618-28. PMID 16489755 DOI: 10.1021/Bi052120V  0.44
2006 Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch M, Growdon J, McLean P, Hyman BT. Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies. Acta Neuropathologica. 111: 101-8. PMID 16482476 DOI: 10.1007/S00401-005-0027-7  0.807
2006 Holtzer R, Irizarry MC, Sanders J, Hyman BT, Wegesin DJ, Riba A, Brandt J, Albert M, Stern Y. Relation of quantitative indexes of concurrent alpha-synuclein abnormalities to clinical outcome in autopsy-proven Alzheimer disease. Archives of Neurology. 63: 226-30. PMID 16476811 DOI: 10.1001/Archneur.63.2.226  0.426
2006 Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT. Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 418-28. PMID 16407538 DOI: 10.1523/Jneurosci.3882-05.2006  0.395
2006 Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 365-71. PMID 16407531 DOI: 10.1523/Jneurosci.3854-05.2006  0.778
2006 Herl L, Lleo A, Thomas AV, Nyborg AC, Jansen K, Golde TE, Hyman BT, Berezovska O. Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. Biochemical and Biophysical Research Communications. 340: 668-74. PMID 16376853 DOI: 10.1016/J.Bbrc.2005.12.063  0.303
2006 Ingelsson M, Blom E, Fukumoto H, Zetterberg H, Gårevik N, Blennow K, Hyman BT, Lannfelt L, Wahlund L, Irizarry MC. P2-160: Csf Aβ and tau levels in Alzheimer’s disease and mild cognitive impairment Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.998  0.396
2006 Callaghan PO, Yu H, Nilsson LNG, Ingelsson M, Hyman BT, Li J, Lindahl U, Lannfelt L, Zhang X. P1-387: Comparative analysis of heparan sulfate co-localization with Aβ40 and Aβ42 in different Aβ deposits of APP transgenic mice and Alzheimer’s disease patients Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.765  0.441
2006 Meyer-Luehmann M, Spires TL, Bacskai BJ, Hyman BT. P1-090: Observation of new senile plaque formation and associated neuritic abnormalities using multiphoton microscopy Alzheimer's & Dementia. 2: S121-S121. DOI: 10.1016/J.Jalz.2006.05.465  0.582
2006 Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT. P4-079: Coordinated expression of APP pathway mRNA and protein in AD Alzheimer's & Dementia. 2: S537-S537. DOI: 10.1016/J.Jalz.2006.05.1817  0.54
2006 Spires TL, Meyer-Luehmann M, Orne JD, Backskai BJ, Hyman BT. P3-434: In vivo multiphoton imaging reveals plaque-related deficits in structural plasticity, underlying dendritic spine loss in Tg2576 mice Alzheimer's & Dementia. 2: S503-S504. DOI: 10.1016/J.Jalz.2006.05.1705  0.301
2006 Thomas AV, Deng A, Herl L, Spoelgen R, Irizarry MC, Hyman BT. O2-03-03: Modulation of neuronal activity results in altered APP processing and spatial alignment of PS1 and APP Alzheimer's & Dementia. 2: S35-S35. DOI: 10.1016/J.Jalz.2006.05.122  0.306
2006 Hyman BT, Spires T, Matsui T, Orne J, Pitstik R, Carlson GA, Ashe K. S2-02-05: Neuritic alterations and dysfunctions in Alzheimer's disease Alzheimer's & Dementia. 2: S26-S26. DOI: 10.1016/J.Jalz.2006.05.085  0.412
2005 Spires TL, Hyman BT. Transgenic models of Alzheimer's disease: learning from animals. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 2: 423-37. PMID 16389306 DOI: 10.1602/Neurorx.2.3.423  0.491
2005 Cantuti-Castelvetri I, Klucken J, Ingelsson M, Ramasamy K, McLean PJ, Frosch MP, Hyman BT, Standaert DG. Alpha-synuclein and chaperones in dementia with Lewy bodies. Journal of Neuropathology and Experimental Neurology. 64: 1058-66. PMID 16319716 DOI: 10.1097/01.Jnen.0000190063.90440.69  0.778
2005 Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease. Neurology. 65: 1402-8. PMID 16275827 DOI: 10.1212/01.Wnl.0000183063.99107.5C  0.516
2005 Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, ... Hyman BT, et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 102: 13461-6. PMID 16174740 DOI: 10.1073/Pnas.0503689102  0.455
2005 Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. Journal of Neurochemistry. 95: 446-56. PMID 16086682 DOI: 10.1111/J.1471-4159.2005.03381.X  0.407
2005 Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7278-87. PMID 16079410 DOI: 10.1523/Jneurosci.1879-05.2005  0.826
2005 Nesterov EE, Skoch J, Hyman BT, Klunk WE, Bacskai BJ, Swager TM. In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. Angewandte Chemie (International Ed. in English). 44: 5452-6. PMID 16059955 DOI: 10.1002/Anie.200500845  0.579
2005 Xiang Z, Nesterov EE, Skoch J, Lin T, Hyman BT, Swager TM, Bacskai BJ, Reeves SA. Detection of myelination using a novel histological probe. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1511-6. PMID 16046669 DOI: 10.1369/Jhc.5A6704.2005  0.512
2005 Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 64: 588-94. PMID 16042310 DOI: 10.1097/01.Jnen.0000171644.00180.Fc  0.79
2005 Koh YH, von Arnim CA, Hyman BT, Tanzi RE, Tesco G. BACE is degraded via the lysosomal pathway. The Journal of Biological Chemistry. 280: 32499-504. PMID 16033761 DOI: 10.1074/Jbc.M506199200  0.369
2005 Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, ... ... Hyman B, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science (New York, N.Y.). 309: 476-81. PMID 16020737 DOI: 10.1126/Science.1113694  0.417
2005 Skoch J, Hickey GA, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy. Methods in Molecular Biology (Clifton, N.J.). 299: 349-63. PMID 15980616 DOI: 10.1385/1-59259-874-9:349  0.629
2005 Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. The Journal of Biological Chemistry. 280: 27303-9. PMID 15917251 DOI: 10.1074/Jbc.M413969200  0.366
2005 Lee J, Fukumoto H, Orne J, Klucken J, Raju S, Vanderburg CR, Irizarry MC, Hyman BT, Ingelsson M. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Experimental Neurology. 194: 91-6. PMID 15899246 DOI: 10.1016/J.Expneurol.2005.01.026  0.398
2005 Skoch J, Dunn A, Hyman BT, Bacskai BJ. Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. Journal of Biomedical Optics. 10: 11007. PMID 15847573 DOI: 10.1117/1.1846075  0.618
2005 Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ. The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. The Journal of Biological Chemistry. 280: 23727-34. PMID 15845543 DOI: 10.1074/Jbc.M503326200  0.738
2005 Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3009-17. PMID 15772361 DOI: 10.1523/Jneurosci.0364-05.2005  0.692
2005 von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, ... Hyman BT, et al. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. The Journal of Biological Chemistry. 280: 17777-85. PMID 15749709 DOI: 10.1074/Jbc.M414248200  0.596
2005 Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, et al. Family-based association between Alzheimer's disease and variants in UBQLN1. The New England Journal of Medicine. 352: 884-94. PMID 15745979 DOI: 10.1056/Nejmoa042765  0.391
2005 Moir RD, Tseitlin KA, Soscia S, Hyman BT, Irizarry MC, Tanzi RE. Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients. The Journal of Biological Chemistry. 280: 17458-63. PMID 15728175 DOI: 10.1074/Jbc.M414176200  0.453
2005 Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. The Journal of Clinical Investigation. 115: 428-33. PMID 15668737 DOI: 10.1172/Jci23269  0.668
2005 Hyman BT, Augustinack JC, Ingelsson M. Transcriptional and conformational changes of the tau molecule in Alzheimer's disease. Biochimica Et Biophysica Acta. 1739: 150-7. PMID 15615634 DOI: 10.1016/J.Bbadis.2004.06.015  0.477
2004 Klucken J, Shin Y, Hyman BT, McLean PJ. A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity. Biochemical and Biophysical Research Communications. 325: 367-73. PMID 15522241 DOI: 10.1016/J.Bbrc.2004.10.037  0.74
2004 von Arnim CA, Tangredi MM, Peltan ID, Lee BM, Irizarry MC, Kinoshita A, Hyman BT. Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy. Journal of Cell Science. 117: 5437-45. PMID 15466887 DOI: 10.1242/Jcs.01422  0.4
2004 Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nature Medicine. 10: 1065-6. PMID 15448688 DOI: 10.1038/Nm1112  0.664
2004 McLean PJ, Klucken J, Shin Y, Hyman BT. Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro. Biochemical and Biophysical Research Communications. 321: 665-9. PMID 15358157 DOI: 10.1016/J.Bbrc.2004.07.021  0.738
2004 Ingelsson M, Jesneck J, Irizarry MC, Hyman BT, Rebeck GW. Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease. Neuroscience Letters. 367: 228-31. PMID 15331159 DOI: 10.1016/J.Neulet.2004.06.011  0.651
2004 Irizarry MC, Deng A, Lleo A, Berezovska O, Von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. Journal of Neurochemistry. 90: 1132-43. PMID 15312168 DOI: 10.1111/J.1471-4159.2004.02581.X  0.635
2004 Green PS, Mendez AJ, Jacob JS, Crowley JR, Growdon W, Hyman BT, Heinecke JW. Neuronal expression of myeloperoxidase is increased in Alzheimer's disease. Journal of Neurochemistry. 90: 724-33. PMID 15255951 DOI: 10.1111/J.1471-4159.2004.02527.X  0.409
2004 Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron. 43: 19-30. PMID 15233914 DOI: 10.1016/J.Neuron.2004.06.021  0.55
2004 Qiu Z, Hyman BT, Rebeck GW. Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons. The Journal of Biological Chemistry. 279: 34948-56. PMID 15169786 DOI: 10.1074/Jbc.M401055200  0.566
2004 Stern EA, Bacskai BJ, Hickey GA, Attenello FJ, Lombardo JA, Hyman BT. Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4535-40. PMID 15140924 DOI: 10.1523/Jneurosci.0462-04.2004  0.645
2004 Mandal AK, Skoch J, Bacskai BJ, Hyman BT, Christmas P, Miller D, Yamin TT, Xu S, Wisniewski D, Evans JF, Soberman RJ. The membrane organization of leukotriene synthesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 6587-92. PMID 15084748 DOI: 10.1073/Pnas.0308523101  0.521
2004 Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ. Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity. The Journal of Biological Chemistry. 279: 25497-502. PMID 15044495 DOI: 10.1074/Jbc.M400255200  0.742
2004 Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC. Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology. 62: 925-31. PMID 15037694 DOI: 10.1212/01.Wnl.0000115115.98960.37  0.777
2004 Lleó A, Berezovska O, Growdon JH, Hyman BT. Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 12: 146-56. PMID 15010344 DOI: 10.1097/00019442-200403000-00006  0.612
2004 Fukumoto H, Rosene DL, Moss MB, Raju S, Hyman BT, Irizarry MC. Beta-secretase activity increases with aging in human, monkey, and mouse brain. The American Journal of Pathology. 164: 719-25. PMID 14742275 DOI: 10.1016/S0002-9440(10)63159-8  0.596
2004 Bacskai BJ, Skoch J, Hickey GA, Berezovska O, Hyman BT. Multiphoton imaging in mouse models of Alzheimer's disease Proceedings of Spie - the International Society For Optical Engineering. 5323: 71-76. DOI: 10.1117/12.537940  0.639
2004 Levene MJ, Dombeck DA, Williams RM, Skoch J, Hickey GA, Kasischke KA, Molloy RP, Ingelsson M, Stern EA, Klucken J, Bacskai BJ, Zipfel WR, Hyman BT, Webb WW. In vivo multiphoton microscopy of deep tissue with gradient index lenses Proceedings of Spie - the International Society For Optical Engineering. 5323: 291-296. DOI: 10.1117/12.537285  0.595
2004 Klucken J, Shin Y, Mclean P, Hyman B. Chaperone mediated degradation of aggregated alpha synuclein Aktuelle Neurologie. 31. DOI: 10.1055/S-2004-833268  0.731
2004 Shin Y, McLean PJ, Hyman BT. P3-268 Chip colocalizes with phosphorylated tau in neurofibrillary tangles in AD brain Neurobiology of Aging. 25: S431. DOI: 10.1016/S0197-4580(04)81418-0  0.777
2004 Ingelsson M, Cantuti-Castelvetri I, Ramasamy K, Orne JD, Augustinack JC, Vanderburg CR, Growdon JH, Frosch MP, Irizarry MC, Standaert DG, Hyman BT. P3-229 Analysis of gene expression in the Alzheimer's disease brain Neurobiology of Aging. 25: S420. DOI: 10.1016/S0197-4580(04)81379-4  0.674
2004 Irizarry MC, Fukumoto H, Daly E, Gunther J, Hyman BT, Albert MS, Blacker D. P3-009 Cross-sectional measures of plasma amyloid-beta protein do not correlate with functional status in prodromal Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81164-3  0.377
2004 McLean PJ, Klucken J, Shin Y, Hyman BT. P1-304 Geldanamycin inhibits but does not reverse alpha-synuclein aggregation Neurobiology of Aging. 25: S183. DOI: 10.1016/S0197-4580(04)80617-1  0.723
2004 Bacskai BJ, Skoch J, Klunk WE, Nesterov E, Swager TM, Mathis CA, Dunn A, Hyman BT. O3-03-04 Novel approaches for non-invasive optical detection of amyloid-β plaques in vivo Neurobiology of Aging. 25: S57-S58. DOI: 10.1016/S0197-4580(04)80194-5  0.55
2004 Moir RD, Tseitlin KA, Soscia S, Hyman BT, Irizarry MC, Tanzi RE. O2-02-08 Levels of autoantibodies to redox-modified abeta are attenuated in the plasma of Alzheimer's disease patients Neurobiology of Aging. 25: S35-S36. DOI: 10.1016/S0197-4580(04)80118-0  0.382
2004 Rebeck GW, Deng A, Hyman BT, Irizarry MC. O1-03-01 Apolipoprotein E inhibits gamma-secretase cleavage of the amyloid precursor protein Neurobiology of Aging. 25: S14. DOI: 10.1016/S0197-4580(04)80044-7  0.574
2004 Lawler SE, S, Ingelsson M, Saeki Y, Hyman BT, Monaco AP, Chiocca EA, Wade-Martins R. The HSV-1 iBAC amplicon vector for functional genomics studies into the genetic mechanisms of neurodegenerative disease Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.835  0.331
2003 Ingelsson M, Shin Y, Irizarry MC, Hyman BT, Lilius L, Forsell C, Graff C. Genotyping of apolipoprotein E: comparative evaluation of different protocols. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Unit9.14. PMID 18428347 DOI: 10.1002/0471142905.Hg0914S38  0.307
2003 Klunk WE, Engler H, Nordberg A, Bacskai BJ, Wang Y, Price JC, Bergström M, Hyman BT, LÃ¥ngström B, Mathis CA. Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography. Neuroimaging Clinics of North America. 13: 781-9, ix. PMID 15024961 DOI: 10.1016/S1052-5149(03)00092-3  0.659
2003 Lombardo JA, Stern EA, McLellan ME, Kajdasz ST, Hickey GA, Bacskai BJ, Hyman BT. Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10879-83. PMID 14645482  0.62
2003 Ramdya P, Skoch J, Bacskai BJ, Hyman BT, Berezovska O. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. Journal of Neurochemistry. 87: 843-50. PMID 14622115 DOI: 10.1046/J.1471-4159.2003.02030.X  0.526
2003 Qiu Z, Crutcher KA, Hyman BT, Rebeck GW. ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes. Neuroscience. 122: 291-303. PMID 14614897 DOI: 10.1016/J.Neuroscience.2003.08.017  0.56
2003 Klucken J, McLean PJ, Gomez-Tortosa E, Ingelsson M, Hyman BT. Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies. Neurochemical Research. 28: 1683-91. PMID 14584822 DOI: 10.1023/A:1026061021946  0.809
2003 Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, Mathis CA, Klunk WE, Hyman BT. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 12462-7. PMID 14517353 DOI: 10.1073/Pnas.2034101100  0.655
2003 Atiya M, Hyman BT, Albert MS, Killiany R. Structural magnetic resonance imaging in established and prodromal Alzheimer disease: a review. Alzheimer Disease and Associated Disorders. 17: 177-95. PMID 14512832 DOI: 10.1097/00002093-200307000-00010  0.401
2003 Lennon NJ, Kho A, Bacskai BJ, Perlmutter SL, Hyman BT, Brown RH. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. The Journal of Biological Chemistry. 278: 50466-73. PMID 14506282 DOI: 10.1074/Jbc.M307247200  0.503
2003 Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. The Journal of Biological Chemistry. 278: 47370-5. PMID 12960155 DOI: 10.1074/Jbc.M308480200  0.346
2003 Fukumoto H, Ingelsson M, GÃ¥revik N, Wahlund LO, Nukina N, Yaguchi Y, Shibata M, Hyman BT, Rebeck GW, Irizarry MC. APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis. Experimental Neurology. 183: 249-53. PMID 12957508 DOI: 10.1016/S0014-4886(03)00088-8  0.623
2003 Irizarry MC, Hyman BT. Brain isoprostanes: a marker of lipid peroxidation and oxidative stress in AD. Neurology. 61: 436-7. PMID 12939413 DOI: 10.1212/Wnl.61.4.436  0.484
2003 Kinoshita A, Shah T, Tangredi MM, Strickland DK, Hyman BT. The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. The Journal of Biological Chemistry. 278: 41182-8. PMID 12888553 DOI: 10.1074/Jbc.M306403200  0.328
2003 Bacskai BJ, Skoch J, Hickey GA, Allen R, Hyman BT. Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques. Journal of Biomedical Optics. 8: 368-75. PMID 12880341 DOI: 10.1117/1.1584442  0.531
2003 Fukumoto H, Tennis M, Locascio JJ, Hyman BT, Growdon JH, Irizarry MC. Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels. Archives of Neurology. 60: 958-64. PMID 12873852 DOI: 10.1001/Archneur.60.7.958  0.59
2003 Berezovska O, Bacskai BJ, Hyman BT. Monitoring proteins in intact cells. Science of Aging Knowledge Environment : Sage Ke. 2003: PE14. PMID 12844526 DOI: 10.1126/Sageke.2003.23.Pe14  0.595
2003 Kinoshita A, Fukumoto H, Shah T, Whelan CM, Irizarry MC, Hyman BT. Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes. Journal of Cell Science. 116: 3339-46. PMID 12829747 DOI: 10.1242/Jcs.00643  0.383
2003 Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4560-6. PMID 12805296  0.567
2003 McLellan ME, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2212-7. PMID 12657680 DOI: 10.1523/Jneurosci.23-06-02212.2003  0.663
2003 Greenberg SM, Bacskai BJ, Hyman BT. Alzheimer disease's double-edged vaccine. Nature Medicine. 9: 389-90. PMID 12640449 DOI: 10.1038/Nm847  0.607
2003 D'Amore JD, Kajdasz ST, McLellan ME, Bacskai BJ, Stern EA, Hyman BT. In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories. Journal of Neuropathology and Experimental Neurology. 62: 137-45. PMID 12578223 DOI: 10.1093/Jnen/62.2.137  0.671
2003 Gomez-Isla T, Irizarry MC, Mariash A, Cheung B, Soto O, Schrump S, Sondel J, Kotilinek L, Day J, Schwarzschild MA, Cha JH, Newell K, Miller DW, Uéda K, Young AB, ... Hyman BT, et al. Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice. Neurobiology of Aging. 24: 245-58. PMID 12498958 DOI: 10.1016/S0197-4580(02)00091-X  0.572
2003 Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 79-81. PMID 12424225 DOI: 10.1096/Fj.02-0394Fje  0.355
2003 Ingelsson M, Hyman BT. Disordered proteins in dementia. Annals of Medicine. 34: 259-71. PMID 12371710 DOI: 10.1080/078538902320322529  0.432
2003 Lombardo JA, Stern EA, McLellan ME, Kajdasz ST, Hickey GA, Bacskai BJ, Hyman BT. Amyloid-β Antibody Treatment Leads to Rapid Normalization of Plaque-Induced Neuritic Alterations The Journal of Neuroscience. 23: 10879-10883. DOI: 10.1523/Jneurosci.23-34-10879.2003  0.66
2003 Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging The Journal of Neuroscience. 23: 4560-4566. DOI: 10.1523/Jneurosci.23-11-04560.2003  0.604
2002 McLean PJ, Kawamata H, Shariff S, Hewett J, Sharma N, Ueda K, Breakefield XO, Hyman BT. TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. Journal of Neurochemistry. 83: 846-54. PMID 12421356 DOI: 10.1046/J.1471-4159.2002.01190.X  0.734
2002 Cheng LL, Newell K, Mallory AE, Hyman BT, Gonzalez RG. Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology Magnetic Resonance Imaging. 20: 527-533. PMID 12413598 DOI: 10.1016/S0730-725X(02)00512-X  0.355
2002 Urbanc B, Cruz L, Le R, Sanders J, Ashe KH, Duff K, Stanley HE, Irizarry MC, Hyman BT. Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 13990-5. PMID 12374847 DOI: 10.1073/Pnas.222433299  0.39
2002 Bacskai BJ, Hyman BT. Alzheimer's disease: what multiphoton microscopy teaches us. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 386-90. PMID 12374422 DOI: 10.1177/107385802236963  0.627
2002 Kinoshita A, Whelan CM, Smith CJ, Berezovska O, Hyman BT. Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus. Journal of Neurochemistry. 82: 839-47. PMID 12358789 DOI: 10.1046/J.1471-4159.2002.01016.X  0.352
2002 Guénette SY, Chang Y, Hyman BT, Tanzi RE, Rebeck GW. Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. Journal of Neurochemistry. 82: 755-62. PMID 12358780 DOI: 10.1046/J.1471-4159.2002.01009.X  0.586
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