Year |
Citation |
Score |
2009 |
Hang JQ, Yang Y, Harris SF, Leveque V, Whittington HJ, Rajyaguru S, Ao-Ieong G, McCown MF, Wong A, Giannetti AM, Le Pogam S, Talamás F, Cammack N, Nájera I, Klumpp K. Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus. The Journal of Biological Chemistry. 284: 15517-29. PMID 19246450 DOI: 10.1074/Jbc.M808889200 |
0.314 |
|
2009 |
Smith DB, Kalayanov G, Sund C, Winqvist A, Pinho P, Maltseva T, Morisson V, Leveque V, Rajyaguru S, Le Pogam S, Najera I, Benkestock K, Zhou XX, Maag H, Cammack N, et al. The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine. Journal of Medicinal Chemistry. 52: 219-23. PMID 19055482 DOI: 10.1021/Jm800981Y |
0.316 |
|
2008 |
Klumpp K, Kalayanov G, Ma H, Le Pogam S, Leveque V, Jiang WR, Inocencio N, De Witte A, Rajyaguru S, Tai E, Chanda S, Irwin MR, Sund C, Winqist A, Maltseva T, et al. 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups. The Journal of Biological Chemistry. 283: 2167-75. PMID 18003608 DOI: 10.1074/Jbc.M708929200 |
0.35 |
|
2007 |
Ma H, Jiang WR, Robledo N, Leveque V, Ali S, Lara-Jaime T, Masjedizadeh M, Smith DB, Cammack N, Klumpp K, Symons J. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. The Journal of Biological Chemistry. 282: 29812-20. PMID 17698842 DOI: 10.1074/Jbc.M705274200 |
0.366 |
|
2006 |
Le Pogam S, Kang H, Harris SF, Leveque V, Giannetti AM, Ali S, Jiang WR, Rajyaguru S, Tavares G, Oshiro C, Hendricks T, Klumpp K, Symons J, Browner MF, Cammack N, et al. Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. Journal of Virology. 80: 6146-54. PMID 16731953 DOI: 10.1128/JVI.02628-05 |
0.305 |
|
2006 |
Klumpp K, Lévêque V, Le Pogam S, Ma H, Jiang WR, Kang H, Granycome C, Singer M, Laxton C, Hang JQ, Sarma K, Smith DB, Heindl D, Hobbs CJ, Merrett JH, et al. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. The Journal of Biological Chemistry. 281: 3793-9. PMID 16316989 DOI: 10.1074/Jbc.M510195200 |
0.316 |
|
2004 |
Davis CA, Hearn AS, Fletcher B, Bickford J, Garcia JE, Leveque V, Melendez JA, Silverman DN, Zucali J, Agarwal A, Nick HS. Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase. Evolutionary conservation of product inhibition. The Journal of Biological Chemistry. 279: 12769-76. PMID 14688256 DOI: 10.1074/Jbc.M310623200 |
0.468 |
|
1999 |
Cabelli DE, Guan Y, Leveque V, Hearn AS, Tainer JA, Nick HS, Silverman DN. Role of tryptophan 161 in catalysis by human manganese superoxide dismutase. Biochemistry. 38: 11686-92. PMID 10512624 DOI: 10.1021/Bi9909142 |
0.621 |
|
1999 |
Ramilo CA, Leveque V, Guan Y, Lepock JR, Tainer JA, Nick HS, Silverman DN. Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase. The Journal of Biological Chemistry. 274: 27711-6. PMID 10488113 DOI: 10.1074/Jbc.274.39.27711 |
0.582 |
|
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