| Year |
Citation |
Score |
| 2023 |
Deans JR, Deol P, Titova N, Radi SH, Vuong LM, Evans JR, Pan S, Fahrmann J, Yang J, Hammock BD, Fiehn O, Fekry B, Eckel-Mahan K, Sladek FM. HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver. Frontiers in Endocrinology. 14: 1266527. PMID 38111711 DOI: 10.3389/fendo.2023.1266527 |
0.302 |
|
| 2020 |
Radi S, Deol P, Deans JR, Fekry B, Eckel-Mahan K, Sladek FM. SUN-LB119 Role of HNF4a Isoforms in the Carbohydrate/Lipid Switch in the Liver and Responsiveness to AMPK Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.2263 |
0.333 |
|
| 2019 |
Sladek FM. 2A. Hepatocyte nuclear factor-4 receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f91/2019.4 |
0.304 |
|
| 2018 |
Fekry B, Ribas-Latre A, Baumgartner C, Deans JR, Kwok C, Patel P, Fu L, Berdeaux R, Sun K, Kolonin MG, Wang SH, Yoo SH, Sladek FM, Eckel-Mahan K. Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma. Nature Communications. 9: 4349. PMID 30341289 DOI: 10.1038/S41467-018-06648-6 |
0.365 |
|
| 2018 |
Reitzel AM, Macrander J, Mane-Padros D, Fang B, Sladek FM, Tarrant AM. Conservation of DNA and Ligand Binding Properties of Retinoid X Receptor from the Placozoan Trichoplax adhaerens to human. The Journal of Steroid Biochemistry and Molecular Biology. PMID 29510228 DOI: 10.1016/J.Jsbmb.2018.02.010 |
0.545 |
|
| 2017 |
Allevato M, Bolotin E, Grossman M, Mane-Padros D, Sladek FM, Martinez E. Sequence-specific DNA binding by MYC/MAX to low-affinity non-E-box motifs. Plos One. 12: e0180147. PMID 28719624 DOI: 10.1371/Journal.Pone.0180147 |
0.803 |
|
| 2016 |
Chellappa K, Deol P, Evans JR, Vuong LM, Chen G, Briançon N, Bolotin E, Lytle C, Nair MG, Sladek FM. Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer. Elife. 5. PMID 27166517 DOI: 10.7554/Elife.10903 |
0.773 |
|
| 2015 |
Vuong LM, Chellappa K, Dhahbi JM, Deans JR, Fang B, Bolotin E, Titova NV, Hoverter NP, Spindler SR, Waterman ML, Sladek FM. Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells. Molecular and Cellular Biology. 35: 3471-90. PMID 26240283 DOI: 10.1128/Mcb.00030-15 |
0.796 |
|
| 2015 |
Deol P, Evans JR, Dhahbi J, Chellappa K, Han DS, Spindler S, Sladek FM. Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver. Plos One. 10: e0132672. PMID 26200659 DOI: 10.1371/Journal.Pone.0132672 |
0.674 |
|
| 2015 |
Chellappa K, Deol P, Evans JR, Vuong LM, Chen G, Briançon N, Bolotin E, Lytle C, Nair MG, Sladek FM. Author response: Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer Elife. DOI: 10.7554/Elife.10903.022 |
0.76 |
|
| 2012 |
Chellappa K, Robertson GR, Sladek FM. HNF4α: a new biomarker in colon cancer? Biomarkers in Medicine. 6: 297-300. PMID 22731903 DOI: 10.2217/Bmm.12.23 |
0.729 |
|
| 2012 |
Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, ... ... Sladek FM, et al. The transcription factor encyclopedia. Genome Biology. 13: R24. PMID 22458515 DOI: 10.1186/Gb-2012-13-3-R24 |
0.758 |
|
| 2012 |
Fang B, Mane-Padros D, Bolotin E, Jiang T, Sladek FM. Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors. Nucleic Acids Research. 40: 5343-56. PMID 22383578 DOI: 10.1093/Nar/Gks190 |
0.816 |
|
| 2012 |
Chellappa K, Jankova L, Schnabl JM, Pan S, Brelivet Y, Fung CL, Chan C, Dent OF, Clarke SJ, Robertson GR, Sladek FM. Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 109: 2302-7. PMID 22308320 DOI: 10.1073/Pnas.1106799109 |
0.737 |
|
| 2011 |
Bolotin E, Chellappa K, Hwang-Verslues W, Schnabl JM, Yang C, Sladek FM. Nuclear receptor HNF4α binding sequences are widespread in Alu repeats. Bmc Genomics. 12: 560. PMID 22085832 DOI: 10.1186/1471-2164-12-560 |
0.779 |
|
| 2011 |
Sladek FM. What are nuclear receptor ligands? Molecular and Cellular Endocrinology. 334: 3-13. PMID 20615454 DOI: 10.1016/J.Mce.2010.06.018 |
0.426 |
|
| 2010 |
Hwang-Verslues WW, Sladek FM. HNF4α--role in drug metabolism and potential drug target? Current Opinion in Pharmacology. 10: 698-705. PMID 20833107 DOI: 10.1016/J.Coph.2010.08.010 |
0.761 |
|
| 2010 |
Bolotin E, Liao H, Ta TC, Yang C, Hwang-Verslues W, Evans JR, Jiang T, Sladek FM. Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays. Hepatology (Baltimore, Md.). 51: 642-53. PMID 20054869 DOI: 10.1002/Hep.23357 |
0.772 |
|
| 2009 |
Yuan X, Ta TC, Lin M, Evans JR, Dong Y, Bolotin E, Sherman MA, Forman BM, Sladek FM. Identification of an endogenous ligand bound to a native orphan nuclear receptor. Plos One. 4: e5609. PMID 19440305 DOI: 10.1371/Journal.Pone.0005609 |
0.788 |
|
| 2009 |
Xie X, Liao H, Dang H, Pang W, Guan Y, Wang X, Shyy JY, Zhu Y, Sladek FM. Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs. Molecular Endocrinology (Baltimore, Md.). 23: 434-43. PMID 19179483 DOI: 10.1210/Me.2007-0531 |
0.414 |
|
| 2008 |
Nammo T, Yamagata K, Tanaka T, Kodama T, Sladek FM, Fukui K, Katsube F, Sato Y, Miyagawa J, Shimomura I. Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas. Gene Expression Patterns : Gep. 8: 96-106. PMID 17996499 DOI: 10.1016/J.Modgep.2007.09.006 |
0.325 |
|
| 2008 |
Hwang-Verslues WW, Sladek FM. Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter. Molecular Endocrinology (Baltimore, Md.). 22: 78-90. PMID 17885207 DOI: 10.1210/Me.2007-0298 |
0.812 |
|
| 2007 |
Sun K, Montana V, Chellappa K, Brelivet Y, Moras D, Maeda Y, Parpura V, Paschal BM, Sladek FM. Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization. Molecular Endocrinology (Baltimore, Md.). 21: 1297-311. PMID 17389749 DOI: 10.1210/Me.2006-0300 |
0.786 |
|
| 2007 |
Yang C, Bolotin E, Jiang T, Sladek FM, Martinez E. Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters. Gene. 389: 52-65. PMID 17123746 DOI: 10.1016/J.Gene.2006.09.029 |
0.798 |
|
| 2006 |
Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. International union of pharmacology. LXVI. Orphan nuclear receptors Pharmacological Reviews. 58: 798-836. PMID 17132856 DOI: 10.1124/Pr.58.4.10 |
0.402 |
|
| 2006 |
Maeda Y, Hwang-Verslues WW, Wei G, Fukazawa T, Durbin ML, Owen LB, Liu X, Sladek FM. Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene. The Biochemical Journal. 400: 303-13. PMID 16895524 DOI: 10.1042/Bj20060614 |
0.802 |
|
| 2006 |
Battle MA, Konopka G, Parviz F, Gaggl AL, Yang C, Sladek FM, Duncan SA. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proceedings of the National Academy of Sciences of the United States of America. 103: 8419-24. PMID 16714383 DOI: 10.1073/Pnas.0600246103 |
0.595 |
|
| 2006 |
Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology. 130: 1207-20. PMID 16618389 DOI: 10.1053/J.Gastro.2006.01.003 |
0.659 |
|
| 2005 |
Ihara A, Yamagata K, Nammo T, Miura A, Yuan M, Tanaka T, Sladek FM, Matsuzawa Y, Miyagawa J, Shimomura I. Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells. Biochemical and Biophysical Research Communications. 329: 984-90. PMID 15752752 DOI: 10.1016/J.Bbrc.2005.02.072 |
0.363 |
|
| 2004 |
Fukazawa T, Maeda Y, Sladek FM, Owen-Schaub LB. Development of a cancer-targeted tissue-specific promoter system. Cancer Research. 64: 363-9. PMID 14729646 DOI: 10.1158/0008-5472.Can-03-2507 |
0.557 |
|
| 2003 |
Sladek FM. Nuclear receptors as drug targets: new developments in coregulators, orphan receptors and major therapeutic areas. Expert Opinion On Therapeutic Targets. 7: 679-84. PMID 14498828 DOI: 10.1517/14728222.7.5.679 |
0.361 |
|
| 2003 |
Li QJ, Yang SH, Maeda Y, Sladek FM, Sharrocks AD, Martins-Green M. MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300. The Embo Journal. 22: 281-91. PMID 12514134 DOI: 10.1093/Emboj/Cdg028 |
0.592 |
|
| 2002 |
Ellrott K, Yang C, Sladek FM, Jiang T. Identifying transcription factor binding sites through Markov chain optimization. Bioinformatics (Oxford, England). 18: S100-9. PMID 12385991 |
0.652 |
|
| 2002 |
Torres-Padilla ME, Sladek FM, Weiss MC. Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes. The Journal of Biological Chemistry. 277: 44677-87. PMID 12205093 DOI: 10.1074/Jbc.M207545200 |
0.48 |
|
| 2002 |
Sladek FM. Desperately seeking...something Molecular Cell. 10: 219-221. PMID 12191466 DOI: 10.1016/S1097-2765(02)00605-6 |
0.426 |
|
| 2002 |
Maeda Y, Rachez C, Hawel L, Byus CV, Freedman LP, Sladek FM. Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205. Molecular Endocrinology (Baltimore, Md.). 16: 1502-10. PMID 12089346 DOI: 10.1210/Mend.16.7.0883 |
0.634 |
|
| 2002 |
Ruse MD, Privalsky ML, Sladek FM. Competitive cofactor recruitment by orphan receptor hepatocyte nuclear factor 4alpha1: modulation by the F domain. Molecular and Cellular Biology. 22: 1626-38. PMID 11865043 DOI: 10.1128/Mcb.22.6.1626-1638.2002 |
0.731 |
|
| 2002 |
Maeda Y, Seidel SD, Wei G, Liu X, Sladek FM. Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. Molecular Endocrinology (Baltimore, Md.). 16: 402-10. PMID 11818510 DOI: 10.1210/Mend.16.2.0769 |
0.678 |
|
| 2000 |
Bogan AA, Dallas-Yang Q, Ruse MD, Maeda Y, Jiang G, Nepomuceno L, Scanlan TS, Cohen FE, Sladek FM. Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha. Journal of Molecular Biology. 302: 831-51. PMID 10993727 DOI: 10.1006/Jmbi.2000.4099 |
0.781 |
|
| 2000 |
Li Q, Vaingankar S, Sladek FM, Martins-Green M. Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression Blood. 96: 3696-3706. DOI: 10.1182/Blood.V96.12.3696.H8003696_3696_3706 |
0.465 |
|
| 2000 |
Li Q, Vaingankar S, Sladek FM, Martins-Green M. Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression Blood. 96: 3696-3706. DOI: 10.1182/blood.V96.12.3696 |
0.361 |
|
| 1999 |
Sladek FM, Ruse MD, Nepomuceno L, Huang SM, Stallcup MR. Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1. Molecular and Cellular Biology. 19: 6509-22. PMID 10490591 DOI: 10.1128/Mcb.19.10.6509 |
0.734 |
|
| 1999 |
Auwerx J, Baulieu E, Beato M, Becker-Andre M, Burbach PH, Camerino G, Chambon P, Cooney A, Dejean A, Dreyer C, Evans RM, Gannon F, Giguere V, Gronemeyer H, Gustafsson JA, ... ... Sladek FM, et al. A unified nomenclature system for the nuclear receptor superfamily Cell. 97: 161-163. PMID 10219237 DOI: 10.1016/S0092-8674(00)80726-6 |
0.364 |
|
| 1998 |
Sladek FM, Dallas-Yang Q, Nepomuceno L. MODY1 mutation Q268X in hepatocyte nuclear factor 4alpha allows for dimerization in solution but causes abnormal subcellular localization. Diabetes. 47: 985-90. PMID 9604881 DOI: 10.2337/Diabetes.47.6.985 |
0.47 |
|
| 1997 |
Jiang G, Lee U, Sladek FM. Proposed mechanism for the stabilization of nuclear receptor DNA binding via protein dimerization Molecular and Cellular Biology. 17: 6546-6554. PMID 9343418 DOI: 10.1128/Mcb.17.11.6546 |
0.427 |
|
| 1997 |
Jiang G, Nepomuceno L, Yang Q, Sladek FM. Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4 Archives of Biochemistry and Biophysics. 340: 1-9. PMID 9126270 DOI: 10.1006/Abbi.1997.9914 |
0.432 |
|
| 1997 |
Jiang G, Sladek FM. The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor α Journal of Biological Chemistry. 272: 1218-1225. PMID 8995424 DOI: 10.1074/Jbc.272.2.1218 |
0.466 |
|
| 1996 |
Marten NW, Sladek FM, Straus DS. Effect of dietary protein restriction on liver transcription factors Biochemical Journal. 317: 361-370. PMID 8713059 DOI: 10.1042/Bj3170361 |
0.478 |
|
| 1995 |
Hall RK, Sladek FM, Granner DK. The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids Proceedings of the National Academy of Sciences of the United States of America. 92: 412-416. PMID 7831301 DOI: 10.1073/Pnas.92.2.412 |
0.493 |
|
| 1995 |
Jiang G, Nepomuceno L, Hopkins K, Sladek FM. Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors Molecular and Cellular Biology. 15: 5131-5143. PMID 7651430 DOI: 10.1128/Mcb.15.9.5131 |
0.479 |
|
| 1993 |
Zhong W, Sladek FM, Darnell JE. The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation. The Embo Journal. 12: 537-44. PMID 8440243 DOI: 10.1002/J.1460-2075.1993.Tb05685.X |
0.478 |
|
| 1993 |
Metzger S, Halaas JL, Breslow JL, Sladek FM. Orphan receptor HNF-4 and bZip protein C/EBPα bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription Journal of Biological Chemistry. 268: 16831-16838. PMID 8344962 |
0.434 |
|
| 1992 |
Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE, Crabtree GR. A transcriptional hierarchy involved in mammalian cell-type specification. Nature. 355: 457-61. PMID 1734282 DOI: 10.1038/355457A0 |
0.441 |
|
| 1992 |
Sladek FM, Darnell JE. Mechanisms of liver-specific gene expression. Current Opinion in Genetics & Development. 2: 256-9. PMID 1638120 DOI: 10.1016/0960-9822(92)90382-K |
0.421 |
|
| 1992 |
Reijnen MJ, Sladek FM, Bertina RM, Reitsma PH. Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden Proceedings of the National Academy of Sciences of the United States of America. 89: 6300-6303. PMID 1631121 DOI: 10.1073/Pnas.89.14.6300 |
0.404 |
|
| 1992 |
Avraham KB, Prezioso VR, Chen WS, Lai E, Sladek FM, Zhong W, Darnell JE, Jenkins NA, Copeland NG. Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4. Genomics. 13: 264-8. PMID 1612587 DOI: 10.1016/0888-7543(92)90241-J |
0.452 |
|
| 1992 |
Mietus-Snyder M, Sladek FM, Ginsburg GS, Kuo CF, Ladias JA, Darnell JE, Karathanasis SK. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Molecular and Cellular Biology. 12: 1708-18. PMID 1312668 |
0.433 |
|
| 1991 |
Xanthopoulos KG, Prezioso VR, Chen WS, Sladek FM, Cortese R, Darnell JE. The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proceedings of the National Academy of Sciences of the United States of America. 88: 3807-11. PMID 2023930 DOI: 10.1073/Pnas.88.9.3807 |
0.461 |
|
| 1990 |
Sladek FM, Zhong WM, Lai E, Darnell JE. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes & Development. 4: 2353-65. PMID 2279702 DOI: 10.1101/Gad.4.12B.2353 |
0.524 |
|
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