| Year |
Citation |
Score |
| 2022 |
Bassot A, Chen J, Takahashi-Yamashiro K, Yap MC, Gibhardt CS, Le GNT, Hario S, Nasu Y, Moore J, Gutiérrez T, Mina L, Mast H, Moses A, Bhat R, Ballanyi K, ... ... Simmen T, et al. The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria. Cell Reports. 111899. PMID 36586409 DOI: 10.1016/j.celrep.2022.111899 |
0.48 |
|
| 2021 |
Bassot A, Chen J, Simmen T. Post-Translational Modification of Cysteines: A Key Determinant of Endoplasmic Reticulum-Mitochondria Contacts (MERCs). Contact (Thousand Oaks (Ventura County, Calif.)). 4: 25152564211001213. PMID 37366382 DOI: 10.1177/25152564211001213 |
0.47 |
|
| 2021 |
Herrera-Cruz MS, Yap MC, Tahbaz N, Phillips K, Thomas L, Thomas G, Simmen T. Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins. Biology Direct. 16: 22. PMID 34743744 DOI: 10.1186/s13062-021-00311-9 |
0.519 |
|
| 2021 |
Chen J, Bassot A, Giuliani F, Simmen T. Amyotrophic Lateral Sclerosis (ALS): Stressed by Dysfunctional Mitochondria-Endoplasmic Reticulum Contacts (MERCs). Cells. 10. PMID 34359958 DOI: 10.3390/cells10071789 |
0.459 |
|
| 2020 |
Yousuf MS, Maguire AD, Simmen T, Kerr BJ. Endoplasmic reticulum-mitochondria interplay in chronic pain: The calcium connection. Molecular Pain. 16: 1744806920946889. PMID 32787562 DOI: 10.1177/1744806920946889 |
0.37 |
|
| 2020 |
Yousuf MS, Samtleben S, Lamothe SM, Friedman TN, Catuneanu A, Thorburn K, Desai M, Tenorio G, Schenk GJ, Ballanyi K, Kurata HT, Simmen T, Kerr BJ. Endoplasmic reticulum stress in the dorsal root ganglia regulates large-conductance potassium channels and contributes to pain in a model of multiple sclerosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32677089 DOI: 10.1096/Fj.202001163R |
0.399 |
|
| 2020 |
Gutiérrez T, Qi H, Yap MC, Tahbaz N, Milburn LA, Lucchinetti E, Lou PH, Zaugg M, LaPointe PG, Mercier P, Overduin M, Bischof H, Burgstaller S, Malli R, Ballanyi K, ... ... Simmen T, et al. The ER chaperone calnexin controls mitochondrial positioning and respiration. Science Signaling. 13. PMID 32606038 DOI: 10.1126/Scisignal.Aax6660 |
0.526 |
|
| 2019 |
Fan Y, Simmen T. Mechanistic Connections between Endoplasmic Reticulum (ER) Redox Control and Mitochondrial Metabolism. Cells. 8. PMID 31547228 DOI: 10.3390/Cells8091071 |
0.638 |
|
| 2019 |
Zhang X, Gibhardt CS, Will T, Stanisz H, Körbel C, Mitkovski M, Stejerean I, Cappello S, Pacheu-Grau D, Dudek J, Tahbaz N, Mina L, Simmen T, Laschke MW, Menger MD, et al. Redox signals at the ER-mitochondria interface control melanoma progression. The Embo Journal. e100871. PMID 31304984 DOI: 10.15252/Embj.2018100871 |
0.463 |
|
| 2019 |
Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, Diaz-Valdivia N, Sanhueza C, Lopez-Crisosto C, Tahbaz N, Rothermel BA, Hill JA, Cifuentes M, Simmen T, Quest AFG, Lavandero S. Author Correction: Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress. Cell Death and Differentiation. PMID 30742089 DOI: 10.1038/S41418-019-0279-8 |
0.424 |
|
| 2018 |
Depaoli MR, Karsten F, Madreiter-Sokolowski CT, Klec C, Gottschalk B, Bischof H, Eroglu E, Waldeck-Weiermair M, Simmen T, Graier WF, Malli R. Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells. Cell Reports. 25: 501-512.e3. PMID 30304688 DOI: 10.1016/J.Celrep.2018.09.027 |
0.312 |
|
| 2018 |
Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, Diaz-Valdivia N, Sanhueza C, Lopez-Crisosto C, Tahbaz N, Rothermel BA, Hill JA, Cifuentes M, Simmen T, Quest AFG, Lavandero S. Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress. Cell Death and Differentiation. PMID 30209302 DOI: 10.1038/S41418-018-0197-1 |
0.542 |
|
| 2018 |
Simmen T, Herrera-Cruz MS. Plastic mitochondria-endoplasmic reticulum (ER) contacts use chaperones and tethers to mould their structure and signaling. Current Opinion in Cell Biology. 53: 61-69. PMID 29870872 DOI: 10.1016/J.Ceb.2018.04.014 |
0.582 |
|
| 2018 |
Yoboue ED, Sitia R, Simmen T. Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages. Cell Death & Disease. 9: 331. PMID 29491367 DOI: 10.1038/S41419-017-0033-4 |
0.571 |
|
| 2018 |
Rybnicek J, Samtleben S, Herrera-Cruz MS, Simmen T. Expression of a T39N mutant Rab32 protein arrests mitochondria movement within neurites of differentiated SH-SY5Y cells. Small Gtpases. 1-4. PMID 29261068 DOI: 10.1080/21541248.2017.1411312 |
0.517 |
|
| 2017 |
Herrera-Cruz MS, Simmen T. Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs). Advances in Experimental Medicine and Biology. 997: 13-31. PMID 28815519 DOI: 10.1007/978-981-10-4567-7_2 |
0.644 |
|
| 2017 |
Simmen T, Tagaya M. Organelle Communication at Membrane Contact Sites (MCS): From Curiosity to Center Stage in Cell Biology and Biomedical Research. Advances in Experimental Medicine and Biology. 997: 1-12. PMID 28815518 DOI: 10.1007/978-981-10-4567-7_1 |
0.425 |
|
| 2017 |
Gutiérrez T, Simmen T. Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death. Cell Calcium. PMID 28619231 DOI: 10.1016/J.Ceca.2017.05.015 |
0.652 |
|
| 2017 |
Herrera-Cruz MS, Simmen T. Cancer: Untethering Mitochondria from the Endoplasmic Reticulum? Frontiers in Oncology. 7: 105. PMID 28603693 DOI: 10.3389/Fonc.2017.00105 |
0.495 |
|
| 2017 |
Thomas G, Aslan JE, Thomas L, Shinde P, Shinde U, Simmen T. Caught in the act - protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease. Journal of Cell Science. PMID 28476937 DOI: 10.1242/Jcs.199463 |
0.475 |
|
| 2017 |
Herrera-Cruz MS, Simmen T. Of yeast, mice and men: MAMs come in two flavors. Biology Direct. 12: 3. PMID 28122638 DOI: 10.1186/S13062-017-0174-5 |
0.601 |
|
| 2017 |
Haile Y, Deng X, Ortiz-Sandoval C, Tahbaz N, Janowicz A, Lu JQ, Kerr BJ, Gutowski NJ, Holley JE, Eggleton P, Giuliani F, Simmen T. Rab32 connects ER stress to mitochondrial defects in multiple sclerosis. Journal of Neuroinflammation. 14: 19. PMID 28115010 DOI: 10.1186/S12974-016-0788-Z |
0.559 |
|
| 2016 |
Raturi A, Gutiérrez T, Ortiz-Sandoval C, Ruangkittisakul A, Herrera-Cruz MS, Rockley JP, Gesson K, Ourdev D, Lou PH, Lucchinetti E, Tahbaz N, Zaugg M, Baksh S, Ballanyi K, Simmen T. TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. The Journal of Cell Biology. PMID 27502484 DOI: 10.1083/Jcb.201512077 |
0.479 |
|
| 2016 |
Appenzeller-Herzog C, Simmen T. ER-luminal thiol/selenol-mediated regulation of Ca2+ signalling. Biochemical Society Transactions. 44: 452-9. PMID 27068954 DOI: 10.1042/Bst20150233 |
0.542 |
|
| 2016 |
Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, et al. Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish. Free Radical Biology & Medicine. PMID 26928585 DOI: 10.1016/J.Freeradbiomed.2016.02.030 |
0.518 |
|
| 2015 |
Arasaki K, Shimizu H, Mogari H, Nishida N, Hirota N, Furuno A, Kudo Y, Baba M, Baba N, Cheng J, Fujimoto T, Ishihara N, Ortiz-Sandoval C, Barlow LD, Raturi A, ... ... Simmen T, et al. A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division. Developmental Cell. 32: 304-17. PMID 25619926 DOI: 10.1016/J.Devcel.2014.12.011 |
0.534 |
|
| 2014 |
Ortiz-Sandoval CG, Hughes SC, Dacks JB, Simmen T. Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins. Cellular Logistics. 4: e986399. PMID 25767741 DOI: 10.4161/21592799.2014.986399 |
0.567 |
|
| 2014 |
Gutiérrez T, Simmen T. Endoplasmic reticulum chaperones and oxidoreductases: critical regulators of tumor cell survival and immunorecognition. Frontiers in Oncology. 4: 291. PMID 25386408 DOI: 10.3389/Fonc.2014.00291 |
0.523 |
|
| 2014 |
Bravo-Sagua R, Torrealba N, Paredes F, Morales PE, Pennanen C, López-Crisosto C, Troncoso R, Criollo A, Chiong M, Hill JA, Simmen T, Quest AF, Lavandero S. Organelle communication: signaling crossroads between homeostasis and disease. The International Journal of Biochemistry & Cell Biology. 50: 55-9. PMID 24534274 DOI: 10.1016/J.Biocel.2014.01.019 |
0.337 |
|
| 2014 |
Raturi A, Ortiz-Sandoval C, Simmen T. Redox dependence of endoplasmic reticulum (ER) Ca²⁺ signaling. Histology and Histopathology. 29: 543-52. PMID 24197491 DOI: 10.14670/Hh-29.10.543 |
0.636 |
|
| 2013 |
Lynes EM, Raturi A, Shenkman M, Sandoval CO, Yap MC, Wu J, Janowicz A, Myhill N, Benson MD, Campbell RE, Berthiaume LG, Lederkremer GZ, Simmen T. Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling Journal of Cell Science. 126: 3893-3903. PMID 23843619 DOI: 10.1242/Jcs.125856 |
0.779 |
|
| 2013 |
Raturi A, Simmen T. Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM). Biochimica Et Biophysica Acta. 1833: 213-24. PMID 22575682 DOI: 10.1016/J.Bbamcr.2012.04.013 |
0.646 |
|
| 2013 |
Veldhoen RA, Banman SL, Hemmerling DR, Odsen R, Simmen T, Simmonds AJ, Underhill DA, Goping IS. The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene. 32: 736-46. PMID 22430212 DOI: 10.1038/Onc.2012.92 |
0.317 |
|
| 2012 |
Alford SC, Ding Y, Simmen T, Campbell RE. Dimerization-dependent green and yellow fluorescent proteins. Acs Synthetic Biology. 1: 569-75. PMID 23656278 DOI: 10.1021/Sb300050J |
0.417 |
|
| 2012 |
Ortiz Sandoval C, Simmen T. Rab proteins of the endoplasmic reticulum: functions and interactors. Biochemical Society Transactions. 40: 1426-32. PMID 23176493 DOI: 10.1042/Bst20120158 |
0.628 |
|
| 2012 |
Lynes EM, Bui M, Yap MC, Benson MD, Schneider B, Ellgaard L, Berthiaume LG, Simmen T. Palmitoylated TMX and calnexin target to the mitochondria-associated membrane. The Embo Journal. 31: 457-70. PMID 22045338 DOI: 10.1038/Emboj.2011.384 |
0.824 |
|
| 2011 |
Lynes EM, Simmen T. Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER. Biochimica Et Biophysica Acta. 1813: 1893-905. PMID 21756943 DOI: 10.1016/J.Bbamcr.2011.06.011 |
0.821 |
|
| 2011 |
Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, et al. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. Journal of Cell Science. 124: 2143-52. PMID 21628424 DOI: 10.1242/Jcs.080762 |
0.514 |
|
| 2011 |
Simmen T. Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease. Expert Opinion On Therapeutic Targets. 15: 741-51. PMID 21391832 DOI: 10.1517/14728222.2011.561787 |
0.483 |
|
| 2010 |
Bui M, Gilady SY, Fitzsimmons RE, Benson MD, Lynes EM, Gesson K, Alto NM, Strack S, Scott JD, Simmen T. Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. The Journal of Biological Chemistry. 285: 31590-602. PMID 20670942 DOI: 10.1074/Jbc.M110.101584 |
0.826 |
|
| 2010 |
Simmen T, Lynes EM, Gesson K, Thomas G. Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM). Biochimica Et Biophysica Acta. 1798: 1465-73. PMID 20430008 DOI: 10.1016/J.Bbamem.2010.04.009 |
0.818 |
|
| 2010 |
Gilady SY, Bui M, Lynes EM, Benson MD, Watts R, Vance JE, Simmen T. Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM). Cell Stress & Chaperones. 15: 619-29. PMID 20186508 DOI: 10.1007/S12192-010-0174-1 |
0.815 |
|
| 2010 |
Roth D, Lynes E, Riemer J, Hansen HG, Althaus N, Simmen T, Ellgaard L. A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4. The Biochemical Journal. 425: 195-205. PMID 19811453 DOI: 10.1042/Bj20091064 |
0.806 |
|
| 2008 |
Myhill N, Lynes EM, Nanji JA, Blagoveshchenskaya AD, Fei H, Carmine Simmen K, Cooper TJ, Thomas G, Simmen T. The subcellular distribution of calnexin is mediated by PACS-2. Molecular Biology of the Cell. 19: 2777-88. PMID 18417615 DOI: 10.1091/Mbc.E07-10-0995 |
0.816 |
|
| 2005 |
Simmen T, Aslan JE, Blagoveshchenskaya AD, Thomas L, Wan L, Xiang Y, Feliciangeli SF, Hung CH, Crump CM, Thomas G. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. The Embo Journal. 24: 717-29. PMID 15692567 DOI: 10.1038/Sj.Emboj.7600559 |
0.614 |
|
| 2005 |
Köttgen M, Benzing T, Simmen T, Tauber R, Buchholz B, Feliciangeli S, Huber TB, Schermer B, Kramer-Zucker A, Höpker K, Simmen KC, Tschucke CC, Sandford R, Kim E, Thomas G, et al. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. The Embo Journal. 24: 705-16. PMID 15692563 DOI: 10.1038/Sj.Emboj.7600566 |
0.488 |
|
| 2005 |
Simmen T, Aslan JE, Blagoveshchenskaya AD, Thomas L, Wan L, Xiang YK, Feliciangeli SF, Hung CH, Crump CM, Thomas G. Erratum: PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis (EMBO Journal (2005) 24 (717-729) doi:10.1038/sj.emboj.7600559) The Embo Journal. 24. DOI: 10.1038/Sj.Emboj.7600637 |
0.353 |
|
| 2004 |
Bertoli G, Simmen T, Anelli T, Molteni SN, Fesce R, Sitia R. Two conserved cysteine triads in human Ero1alpha cooperate for efficient disulfide bond formation in the endoplasmic reticulum. The Journal of Biological Chemistry. 279: 30047-52. PMID 15136577 DOI: 10.1074/Jbc.M403192200 |
0.422 |
|
| 2003 |
Anelli T, Alessio M, Bachi A, Bergamelli L, Bertoli G, Camerini S, Mezghrani A, Ruffato E, Simmen T, Sitia R. Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44. The Embo Journal. 22: 5015-22. PMID 14517240 DOI: 10.1093/Emboj/Cdg491 |
0.588 |
|
| 2003 |
Cunnea PM, Miranda-Vizuete A, Bertoli G, Simmen T, Damdimopoulos AE, Hermann S, Leinonen S, Huikko MP, Gustafsson JA, Sitia R, Spyrou G. ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. The Journal of Biological Chemistry. 278: 1059-66. PMID 12411443 DOI: 10.1074/Jbc.M206995200 |
0.662 |
|
| 2002 |
Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R. ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. The Embo Journal. 21: 835-44. PMID 11847130 DOI: 10.1093/Emboj/21.4.835 |
0.589 |
|
| 2002 |
Simmen T, Höning S, Icking A, Tikkanen R, Hunziker W. AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells. Nature Cell Biology. 4: 154-9. PMID 11802162 DOI: 10.1038/Ncb745 |
0.324 |
|
| 2001 |
Mezghrani A, Fassio A, Benham A, Simmen T, Braakman I, Sitia R. Manipulation of oxidative protein folding and PDI redox state in mammalian cells. The Embo Journal. 20: 6288-96. PMID 11707400 DOI: 10.1093/Emboj/20.22.6288 |
0.489 |
|
| 1999 |
Simmen T, Nobile M, Bonifacino JS, Hunziker W. Basolateral sorting of furin in MDCK cells requires a phenylalanine- isoleucine motif together with an acidic amino acid cluster Molecular and Cellular Biology. 19: 3136-3144. PMID 10082580 DOI: 10.1128/Mcb.19.4.3136 |
0.411 |
|
| 1999 |
Simmen T, Schmidt A, Hunziker W, Beermann F. The tyrosinase tail mediates sorting to the lysosomal compartment in MDCK cells via a di-leucine and a tyrosine-based signal Journal of Cell Science. 112: 45-53. PMID 9841903 |
0.391 |
|
| 1996 |
Hunziker W, Simmen T, Höning S. Trafficking of lysosomal membrane proteins in polarized kidney cells Nephrologie. 17: 347-350. PMID 8987042 |
0.42 |
|
| 1996 |
Cals MM, Guenzi S, Carelli S, Simmen T, Sparvoli A, Sitia R. IgM polymerization inhibits the Golgi-mediated processing of the μ-chain carboxy-terminal glycans Molecular Immunology. 33: 15-24. PMID 8604220 DOI: 10.1016/0161-5890(95)00132-8 |
0.329 |
|
| 1995 |
Wahlberg JM, Geffen I, Reymond F, Simmen T, Spiess M. trans-Golgi retention of a plasma membrane protein: mutations in the cytoplasmic domain of the asialoglycoprotein receptor subunit H1 result in trans-Golgi retention. The Journal of Cell Biology. 130: 285-97. PMID 7615632 DOI: 10.1083/Jcb.130.2.285 |
0.359 |
|
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