| Year |
Citation |
Score |
| 2024 |
Takada H, Demoruelle MK, Deane KD, Nakamura S, Katsumata Y, Ikari K, Buckner JH, Robinson WH, Seifert JA, Feser ML, Moss L, Norris JM, Harigai M, Hsieh EWY, Holers VM, et al. Expansion of HLA-DR Peripheral Helper T and Naïve B cells in Anti-Citrullinated Protein Antibody-Positive Subjects At-Risk for Rheumatoid Arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 38412870 DOI: 10.1002/art.42839 |
0.308 |
|
| 2023 |
Fechtner S, Allen BE, Chriswell ME, Jubair WK, Robertson CE, Kofonow JN, Frank DN, Holers VM, Kuhn KA. 3,3-dimethyl-1-butanol and its metabolite 3,3-dimethylbutyrate ameliorate collagen-induced arthritis independent of choline trimethylamine lyase activity. Research Square. PMID 37720032 DOI: 10.21203/rs.3.rs-3297018/v1 |
0.63 |
|
| 2023 |
Brewer RC, Lanz TV, Hale CR, Sepich-Poore GD, Martino C, Swafford AD, Carroll TS, Kongpachith S, Blum LK, Elliott SE, Blachere NE, Parveen S, Fak J, Yao V, Troyanskaya O, ... ... Holers VM, et al. Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Science Translational Medicine. 15: eabq8476. PMID 36812347 DOI: 10.1126/scitranslmed.abq8476 |
0.3 |
|
| 2022 |
Holers VM, Kuhn KA, Demoruelle MK, Norris JM, Firestein GS, James EA, Robinson WH, Buckner JH, Deane KD. Mechanism-driven strategies for prevention of rheumatoid arthritis. Rheumatology & Autoimmunity. 2: 109-119. PMID 36312783 DOI: 10.1002/rai2.12043 |
0.625 |
|
| 2022 |
Chriswell ME, Lefferts AR, Clay MR, Hsu AR, Seifert J, Feser ML, Rims C, Bloom MS, Bemis EA, Liu S, Maerz MD, Frank DN, Demoruelle MK, Deane KD, James EA, ... ... Holers VM, et al. Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of . Science Translational Medicine. 14: eabn5166. PMID 36288282 DOI: 10.1126/scitranslmed.abn5166 |
0.639 |
|
| 2022 |
Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM. Factor H Related Proteins Modulate Complement Activation on Kidney Cells. Kidney International. PMID 36063874 DOI: 10.1016/j.kint.2022.07.035 |
0.644 |
|
| 2022 |
Banda NK, Deane KD, Bemis EA, Strickland C, Seifert J, Jordan K, Goldman K, Morgan BP, Moreland LW, Lewis MJ, Pitzalis C, Holers VM. Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features. Journal of Immunology (Baltimore, Md. : 1950). PMID 35500934 DOI: 10.4049/jimmunol.2101170 |
0.304 |
|
| 2021 |
Demoruelle MK, Wang H, Davis RL, Visser A, Hoang J, Norris JM, Holers VM, Deane KD, Darrah E. Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis. Arthritis Research & Therapy. 23: 163. PMID 34092252 DOI: 10.1186/s13075-021-02528-5 |
0.31 |
|
| 2021 |
Mangalea MR, Paez-Espino D, Kieft K, Chatterjee A, Chriswell ME, Seifert JA, Feser ML, Demoruelle MK, Sakatos A, Anantharaman K, Deane KD, Kuhn KA, Holers VM, Duerkop BA. Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential. Cell Host & Microbe. PMID 33957082 DOI: 10.1016/j.chom.2021.03.020 |
0.613 |
|
| 2020 |
Okamato Y, Ghosh T, Okamoto T, Schuyler RP, Seifert J, Charry LL, Visser A, Feser M, Fleischer C, Pedrick C, August J, Moss L, Bemis EA, Norris JM, Kuhn KA, ... ... Holers VM, et al. Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14 monocytes. Journal of Autoimmunity. 117: 102581. PMID 33310262 DOI: 10.1016/j.jaut.2020.102581 |
0.625 |
|
| 2020 |
Banda NK, Tomlinson S, Scheinman RI, Ho N, Ramirez JR, Mehta G, Wang G, Vu VP, Simberg D, Kulik L, Holers VM. C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice. Frontiers in Immunology. 11: 575154. PMID 33178202 DOI: 10.3389/fimmu.2020.575154 |
0.3 |
|
| 2020 |
Bemis EA, Demoruelle MK, Seifert JA, Polinski KJ, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, ODell JR, Keating RM, Deane KD, Holers VM, Norris JM. Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clinical setting. Annals of the Rheumatic Diseases. PMID 32928740 DOI: 10.1136/Annrheumdis-2020-217066 |
0.339 |
|
| 2020 |
Holers VM. Challenges and Opportunities: Using Omics to Generate Testable Insights into Pathogenic Mechanisms in Preclinical Seropositive Rheumatoid Arthritis Arthritis & Rheumatism. PMID 32776474 DOI: 10.1002/Art.41479 |
0.368 |
|
| 2020 |
Juge PA, Lee JS, Lau J, Kawano-Dourado L, Rojas Serrano J, Sebastiani M, Koduri G, Matteson E, Bonfiglioli K, Sawamura M, Kairalla R, Cavagna L, Bozzalla Cassione E, Manfredi A, Mejia M, ... ... Holers VM, et al. Methotrexate and rheumatoid arthritis associated interstitial lung disease. The European Respiratory Journal. PMID 32646919 DOI: 10.1183/13993003.00337-2020 |
0.363 |
|
| 2020 |
Deane KD, Holers VM. Rheumatoid Arthritis: Pathogenesis, Prediction and Prevention – An Emerging Paradigm Shift Arthritis & Rheumatism. PMID 32602263 DOI: 10.1002/Art.41417 |
0.373 |
|
| 2020 |
Song YJ, Choi IA, Meylan F, Demoruelle MK, Farley T, Richard AC, Hawley E, Botson J, Hong YJ, Lee EY, Mian SR, Hamilton BC, Thiele GM, Mikuls TR, Gara N, ... ... Holers VM, et al. Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF. Arthritis Research & Therapy. 22: 106. PMID 32381123 DOI: 10.1186/S13075-020-02198-9 |
0.387 |
|
| 2020 |
Ayyappan P, Harms RZ, Seifert JA, Bemis EA, Feser ML, Deane KD, Demoruelle MK, Mikuls TR, Holers VM, Sarvetnick NE. Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis. Frontiers in Immunology. 11: 427. PMID 32265916 DOI: 10.3389/Fimmu.2020.00427 |
0.405 |
|
| 2020 |
Holers VM, Borodovsky A, Scheinman RI, Ho N, Ramirez JR, Dobó J, Gál P, Lindenberger J, Hansen AG, Desai D, Pihl R, Thiel S, Banda NK. Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D. Frontiers in Immunology. 11: 201. PMID 32153567 DOI: 10.3389/Fimmu.2020.00201 |
0.439 |
|
| 2019 |
Kulik L, Laskowski J, Renner B, Woolaver R, Zhang L, Lyubchenko T, You Z, Thurman JM, Holers VM. Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus. Journal of Immunology (Baltimore, Md. : 1950). PMID 31732528 DOI: 10.4049/Jimmunol.1900620 |
0.389 |
|
| 2019 |
Polinski KJ, Bemis EA, Feser M, Seifert J, Demoruelle MK, Striebich CC, Brake S, O'Dell JR, Mikuls TR, Weisman MH, Gregersen PK, Keating RM, Buckner J, Nicassio P, Holers VM, et al. Perceived stress and inflammatory arthritis: a prospective investigation in the Studies of the Etiologies of Rheumatoid Arthritis (SERA) cohort. Arthritis Care & Research. PMID 31600025 DOI: 10.1002/Acr.24085 |
0.369 |
|
| 2019 |
Slight-Webb S, Bourn RL, Holers VM, James JA. Shared and unique immune alterations in pre-clinical autoimmunity. Current Opinion in Immunology. 61: 60-68. PMID 31557691 DOI: 10.1016/J.Coi.2019.08.006 |
0.311 |
|
| 2019 |
Kelmenson LB, Wagner BD, McNair BK, Frazer-Abel A, Demoruelle KM, Bergstedt DT, Feser ML, Moss LK, Parish MC, Mewshaw EA, Mikuls VTR, Edison JD, Holers VM, Deane KD. Timing of elevations of autoantibody isotypes in rheumatoid arthritis prior to disease diagnosis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 31464042 DOI: 10.1002/Art.41091 |
0.405 |
|
| 2019 |
Bemis EA, Norris JM, Seifert J, Frazer-Abel A, Okamoto Y, Feser ML, Demoruelle MK, Deane KD, Banda NK, Holers VM. Complement and its environmental determinants in the progression of human rheumatoid arthritis. Molecular Immunology. 112: 256-265. PMID 31207549 DOI: 10.1016/J.Molimm.2019.05.012 |
0.416 |
|
| 2019 |
Raza K, Holers VM, Gerlag D. Nomenclature for the Phases of the Development of Rheumatoid Arthritis. Clinical Therapeutics. 41: 1279-1285. PMID 31196657 DOI: 10.1016/J.Clinthera.2019.04.013 |
0.373 |
|
| 2019 |
Deane KD, Holers VM. The Natural History of Rheumatoid Arthritis. Clinical Therapeutics. PMID 31196652 DOI: 10.1016/J.Clinthera.2019.04.028 |
0.381 |
|
| 2019 |
Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Meyers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, ... ... Holers VM, et al. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. PMID 31101752 DOI: 10.3324/Haematol.2018.197210 |
0.646 |
|
| 2019 |
Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, ... ... Holers VM, et al. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nature Immunology. PMID 31061532 DOI: 10.1038/S41590-019-0378-1 |
0.37 |
|
| 2019 |
Berens HM, Polinski KJ, Mikuls TR, Khatter S, August J, Visser A, Mahler M, Weisman M, O'Dell JR, Keating RM, Buckner JH, Gregersen PK, Norris JM, Holers VM, Deane KD, et al. Anti-CCP3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis. The Journal of Rheumatology. PMID 30988128 DOI: 10.3899/Jrheum.180897 |
0.377 |
|
| 2019 |
Gifford G, Vu VP, Banda NK, Holers VM, Wang G, Groman E, Backos D, Scheinman R, Moghimi SM, Simberg D. Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30974134 DOI: 10.1016/J.Jconrel.2019.04.009 |
0.335 |
|
| 2019 |
James JA, Chen H, Young KA, Bemis EA, Seifert J, Bourn RL, Deane KD, Demoruelle MK, Feser M, O'Dell JR, Weisman MH, Keating RM, Gaffney PM, Kelly JA, Langefeld CD, ... ... Holers VM, et al. Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients. Ebiomedicine. PMID 30952617 DOI: 10.1016/J.Ebiom.2019.03.063 |
0.328 |
|
| 2019 |
Holers VM. Sp0170 Is Complement A Critical Ingredient In The Development Of Ra Annals of the Rheumatic Diseases. 78: 51-52. DOI: 10.1136/Annrheumdis-2019-Eular.8502 |
0.449 |
|
| 2019 |
Deane KD, Nagpal S, Rao N, Baribaud F, Vratsanos G, James EA, Buckner JH, Firestein GS, Boyle DL, Posso S, Robinson WH, Moss LK, Barzideh S, Polinski K, Ivanov S, ... ... Holers VM, et al. Sat0082 Associations Of Baseline Clinical And Biomarker Factors With Symptoms And Future Development Of Clinically-Apparent Rheumatoid Arthritis In An Acpa Positive Cohort Annals of the Rheumatic Diseases. 78: 1105-1105. DOI: 10.1136/Annrheumdis-2019-Eular.1297 |
0.382 |
|
| 2018 |
Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD. Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction. Nature Reviews. Rheumatology. PMID 30111803 DOI: 10.1038/S41584-018-0070-0 |
0.651 |
|
| 2018 |
Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, ... ... Holers VM, et al. Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arthritis Research & Therapy. 20: 139. PMID 29996944 DOI: 10.1186/S13075-018-1631-Y |
0.375 |
|
| 2018 |
Hughes-Austin JM, Deane KD, Giles JT, Derber LA, Zerbe GO, Dabelea DM, Sokolove J, Robinson WH, Holers VM, Norris JM. Plasma adiponectin levels are associated with circulating inflammatory cytokines in autoantibody positive first-degree relatives of rheumatoid arthritis patients. Plos One. 13: e0199578. PMID 29940013 DOI: 10.1371/Journal.Pone.0199578 |
0.391 |
|
| 2018 |
Holers VM, Banda NK. Complement in the Initiation and Evolution of Rheumatoid Arthritis. Frontiers in Immunology. 9: 1057. PMID 29892280 DOI: 10.3389/Fimmu.2018.01057 |
0.418 |
|
| 2018 |
Verheul MK, Böhringer S, van Delft MAM, Jones JD, Rigby WFC, Gan RW, Holers VM, Edison JD, Deane KD, Janssen KMJ, Westra J, Brink M, Rantapää-Dahlqvist S, Huizinga TWJ, van der Helm-van Mil AHM, et al. The combination of three autoantibodies, ACPA, RF and anti-CarP antibodies is highly specific for rheumatoid arthritis: implications for very early identification of individuals at risk to develop rheumatoid arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29781231 DOI: 10.1002/Art.40562 |
0.413 |
|
| 2018 |
Mihai S, Hirose M, Wang Y, Thurman JM, Holers VM, Morgan BP, Köhl J, Zillikens D, Ludwig RJ, Nimmerjahn F. Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice. Frontiers in Immunology. 9: 535. PMID 29616034 DOI: 10.3389/Fimmu.2018.00535 |
0.424 |
|
| 2018 |
Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. European Journal of Immunology. PMID 29389016 DOI: 10.1002/Eji.201747240 |
0.325 |
|
| 2018 |
Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. Journal of Immunology (Baltimore, Md. : 1950). 200: 316-326. PMID 29187587 DOI: 10.4049/Jimmunol.1602017 |
0.369 |
|
| 2018 |
Banda NK, Ramirez JR, Yang X, Khan N, Wang G, Simberg D, Kulik L, Tomlinson S, Holers VM. Recombinant single chain antibody-fused complement inhibitor locally target and attenuates arthritis in mice Molecular Immunology. 102: 133-134. DOI: 10.1016/J.Molimm.2018.06.028 |
0.366 |
|
| 2017 |
Demoruelle MK, Bowers E, Lahey LJ, Sokolove J, Purmalek M, Seto NL, Weisman MH, Norris JM, Kaplan MJ, Holers VM, William RH, Deane KD. Antibody Responses to Citrullinated and Non-Citrullinated Antigens in the Sputum of Subjects with and At-Risk for Rheumatoid Arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29266801 DOI: 10.1002/Art.40401 |
0.392 |
|
| 2017 |
Hughes-Austin JM, Gan RW, Deane KD, Weisman MH, Demoruelle MK, Sokolove J, Robinson WH, Holers VM, Norris JM, Ix JH. Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis. American Journal of Nephrology. 46: 481-487. PMID 29237149 DOI: 10.1159/000485259 |
0.381 |
|
| 2017 |
Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM. Genetic and environmental risk factors for rheumatoid arthritis. Best Practice & Research. Clinical Rheumatology. 31: 3-18. PMID 29221595 DOI: 10.1016/J.Berh.2017.08.003 |
0.635 |
|
| 2017 |
Gan RW, Bemis EA, Demoruelle MK, Striebich CC, Brake S, Feser ML, Moss L, Clare-Salzler M, Holers VM, Deane KD, Norris JM. The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population. Rheumatology (Oxford, England). PMID 29029330 DOI: 10.1093/Rheumatology/Kex360 |
0.37 |
|
| 2017 |
He YG, Pappworth IY, Rossbach A, Paulin J, Mavimba T, Hayes C, Kulik L, Holers VM, Knight AM, Marchbank KJ. A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice. Immunobiology. PMID 29017821 DOI: 10.1016/J.Imbio.2017.10.002 |
0.364 |
|
| 2017 |
Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y, Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H, Holers VM. Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2. Journal of Immunology (Baltimore, Md. : 1950). PMID 28739878 DOI: 10.4049/Jimmunol.1700119 |
0.426 |
|
| 2017 |
Thurman JM, Frazer‐Abel A, Holers VM. Review: The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases Arthritis & Rheumatism. 69: 2102-2113. PMID 28732131 DOI: 10.1002/Art.40219 |
0.383 |
|
| 2017 |
Birru Talabi M, Mackey RH, Kuller LH, Dorman JS, Deane KD, Robinson WH, Walitt BT, Chang Y, Holers VM, Liu S, Moreland LW. HLA-Shared Epitope, Inflammation, Mortality, CVD and Malignancy Among Postmenopausal Women With and Without Rheumatoid Arthritis in the Women's Health. American Journal of Epidemiology. PMID 28459968 DOI: 10.1093/Aje/Kwx087 |
0.385 |
|
| 2017 |
Wang G, Griffin JI, Inturi S, Brenneman B, Banda NK, Holers VM, Moghimi SM, Simberg D. In Vitro and In Vivo Differences in Murine Third Complement Component (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms. Frontiers in Immunology. 8: 151. PMID 28239384 DOI: 10.3389/Fimmu.2017.00151 |
0.364 |
|
| 2017 |
Deane KD, Striebich CC, Holers VM. Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed? Arthritis & Rheumatology (Hoboken, N.J.). 69: 873-877. PMID 28217918 DOI: 10.1002/Art.40061 |
0.351 |
|
| 2017 |
Demoruelle MK, Harrall KK, Ho L, Purmalek MM, Seto NL, Rothfuss HM, Weisman MH, Solomon JJ, Fischer A, Okamoto Y, Kelmenson LB, Parish MC, Feser M, Fleischer C, Anderson C, ... ... Holers VM, et al. Anti-citrullinated protein antibodies are associated with neutrophil extracellular traps in the sputum in relatives of rheumatoid arthritis patients. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28182854 DOI: 10.1002/Art.40066 |
0.414 |
|
| 2017 |
Willis VC, Banda NK, Cordova KN, Chandra PE, Robinson WH, Cooper DC, Lugo D, Mehta G, Taylor S, Tak PP, Prinjha RK, Lewis HD, Holers VM. PAD4 Inhibition is Sufficient for the Amelioration of Collagen-Induced Arthritis. Clinical and Experimental Immunology. PMID 28128853 DOI: 10.1111/Cei.12932 |
0.782 |
|
| 2017 |
Banda NK, Desai D, Casterano A, Scheinman RI, Acharya S, Sekine H, Fujita T, Hansen AG, Thiel S, Borodovsky A, Holers VM. siRNA-mediated targeting of hepatocyte mannan-binding lectin-associated serine protease-3 for the treatment of murine collagen-antibody-inducsed arthritis (CAIA), a model for human rheumatoid arthritis Molecular Immunology. 89: 161. DOI: 10.1016/J.Molimm.2017.06.129 |
0.405 |
|
| 2016 |
Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. Plos One. 11: e0166200. PMID 27814381 DOI: 10.1371/Journal.Pone.0166200 |
0.335 |
|
| 2016 |
Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, et al. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. Jci Insight. 1: e90045. PMID 27777982 DOI: 10.1172/Jci.Insight.90045 |
0.39 |
|
| 2016 |
Banda NK, Acharya S, Scheinman RI, Mehta G, Coulombe M, Takahashi M, Sekine H, Thiel S, Fujita T, Holers VM. Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing. Journal of Immunology (Baltimore, Md. : 1950). PMID 27707997 DOI: 10.4049/Jimmunol.1600719 |
0.43 |
|
| 2016 |
Holers VM, Tomlinson S, Kulik L, Atkinson C, Rohrer B, Banda N, Thurman JM. New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities. Seminars in Immunology. PMID 27282113 DOI: 10.1016/J.Smim.2016.05.007 |
0.648 |
|
| 2016 |
Kinslow JD, Blum LK, Deane KD, Demoruelle MK, Okamoto Y, Parish M, Kongpachith S, Lahey LJ, Norris JM, Robinson WH, Holers VM. IgA Plasmablasts are Elevated in Subjects At Risk for Future Rheumatoid Arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 27273876 DOI: 10.1002/Art.39771 |
0.385 |
|
| 2016 |
Gan RW, Demoruelle MK, Deane KD, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Fingerlin TE, Zerbe GO, Clare-Salzler MJ, Holers VM, Norris JM. Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis. Annals of the Rheumatic Diseases. PMID 27190099 DOI: 10.1136/Annrheumdis-2016-209154 |
0.346 |
|
| 2016 |
Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan JP, Ljubanovic D, Ruseva MM, Borza DB, Antonioli AH, Pickering MC, Holers VM, Thurman JM. Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury. Kidney International. PMID 27165610 DOI: 10.1016/J.Kint.2016.02.036 |
0.343 |
|
| 2016 |
Sparks JA, Chang SC, Deane KD, Gan RW, Demoruelle MK, Feser ML, Moss L, Buckner JH, Keating RM, Costenbader KH, Gregersen PK, Weisman MH, Mikuls TR, O'Dell JR, Holers VM, et al. Associations of smoking and age with inflammatory joint signs among first-degree relatives without rheumatoid arthritis: Results from the Studies of the Etiology of RA. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26866831 DOI: 10.1002/Art.39630 |
0.375 |
|
| 2016 |
Raza K, Klareskog L, Holers VM. Predicting and preventing the development of rheumatoid arthritis. Rheumatology (Oxford, England). 55: 1-3. PMID 26224307 DOI: 10.1093/Rheumatology/Kev261 |
0.333 |
|
| 2016 |
Kulik L, Laskowski J, Thurman JM, Holers VM. AI-09 Treatment of MRL/LPR mice with a mab blocking binding of C3D to its receptors decreases ANTI-DNA autoantibodies and proteinuria: support for targeting the CR2:C3D interaction as a therapeutic strategy in SLE Lupus Science & Medicine. 3. DOI: 10.1136/Lupus-2016-000179.9 |
0.396 |
|
| 2016 |
Holers VM, Laskowski J, Thurman JM, Kulik L. Treatment of a murine model of human lupus with a monoclonal antibody that blocks binding of C3d to its receptors decreases anti-DNA autoantibodies and proteinuria: Implications for the CR2:C3d interaction as a therapeutic target in lupus and other autoimmune diseases Immunobiology. 221: 1212. DOI: 10.1016/J.Imbio.2016.06.194 |
0.383 |
|
| 2016 |
Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Mortensen S, Thiel S, Sekine H, Fujita T, Holers VM. Targeted inhibition by RNA interference-mediated gene silencing of mannan-binding lectin-associated serine protease (MASP)-1/3 expression attenuates collagen antibody-induced arthritis (CAIA) Immunobiology. 221: 1131-1132. DOI: 10.1016/J.Imbio.2016.06.017 |
0.329 |
|
| 2015 |
Inturi S, Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D. Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake. Acs Nano. PMID 26488074 DOI: 10.1021/Acsnano.5B05061 |
0.337 |
|
| 2015 |
Gan RW, Young KA, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Clare-Salzler MJ, Deane KD, Holers VM, Norris JM. Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study. Rheumatology (Oxford, England). PMID 26370400 DOI: 10.1093/Rheumatology/Kev266 |
0.335 |
|
| 2015 |
Mackey RH, Kuller LH, Deane KD, Walitt BT, Chang YF, Holers VM, Robinson WH, Tracy RP, Hlatky MA, Eaton C, Liu S, Freiberg MS, Birru Talabi M, Schelbert EB, Moreland LW. Rheumatoid arthritis, anti-CCP positivity, and cardiovascular disease risk in the Women's Health Initiative. Arthritis & Rheumatology (Hoboken, N.J.). PMID 25988241 DOI: 10.1002/Art.39198 |
0.349 |
|
| 2015 |
Holers VM. Targeting mechanisms at sites of complement activation for imaging and therapy. Immunobiology. PMID 25979851 DOI: 10.1016/J.Imbio.2015.04.005 |
0.391 |
|
| 2015 |
Panzer SE, Laskowski J, Renner B, Kulik L, Ljubanovic D, Huber KM, Zhong W, Pickering MC, Holers VM, Thurman JM. IgM exacerbates glomerular disease progression in complement-induced glomerulopathy. Kidney International. PMID 25945405 DOI: 10.1038/Ki.2015.120 |
0.388 |
|
| 2015 |
Mehta G, Scheinman RI, Holers VM, Banda NK. A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA. Journal of Immunology (Baltimore, Md. : 1950). 194: 5446-54. PMID 25917104 DOI: 10.4049/Jimmunol.1403012 |
0.443 |
|
| 2015 |
Atkinson C, Qiao F, Yang X, Zhu P, Reaves N, Kulik L, Goddard M, Holers VM, Tomlinson S. Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury. Circulation. 131: 1171-80. PMID 25825397 DOI: 10.1161/Circulationaha.114.010482 |
0.329 |
|
| 2015 |
Cruickshank MN, Dods J, Taylor RL, Karimi M, Fenwick EJ, Quail EA, Rea AJ, Holers VM, Abraham LJ, Ulgiati D. Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility. The International Journal of Biochemistry & Cell Biology. 64: 107-19. PMID 25817480 DOI: 10.1016/J.Biocel.2015.03.016 |
0.338 |
|
| 2015 |
Kulik L, Hewitt FB, Willis VC, Rodriguez R, Tomlinson S, Holers VM. A new mouse anti-mouse complement receptor type 2 and 1 (CR2/CR1) monoclonal antibody as a tool to study receptor involvement in chronic models of immune responses and disease. Molecular Immunology. 63: 479-88. PMID 25457881 DOI: 10.1016/J.Molimm.2014.10.005 |
0.424 |
|
| 2015 |
Liang MH, Couto MC, Duarte CC, Gall V, White P, Naides S, Schumacher HR, Hwang AS, Holers VM, Deane KD, Gupta S, Ho IC, Finckh A, Kopec J, Choi CB, et al. An Internet-based technique for the identification of persons with symptoms of inflammatory polyarthritis of less than 12 weeks. Clinical Rheumatology. 34: 465-70. PMID 25339123 DOI: 10.1007/S10067-014-2796-7 |
0.331 |
|
| 2014 |
Holers VM. Insights from populations at risk for the future development of classified rheumatoid arthritis. Rheumatic Diseases Clinics of North America. 40: 605-20. PMID 25437280 DOI: 10.1016/J.Rdc.2014.07.003 |
0.411 |
|
| 2014 |
Neher MD, Rich MC, Keene CN, Weckbach S, Bolden AL, Losacco JT, Patane J, Flierl MA, Kulik L, Holers VM, Stahel PF. Deficiency of complement receptors CR2/CR1 in Cr2⁻/⁻ mice reduces the extent of secondary brain damage after closed head injury. Journal of Neuroinflammation. 11: 95. PMID 24885042 DOI: 10.1186/1742-2094-11-95 |
0.341 |
|
| 2014 |
Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Liu S, Parks CG, Wright NC, Moreland LW. Determinants of mortality among postmenopausal women in the women's health initiative who report rheumatoid arthritis. Arthritis & Rheumatology (Hoboken, N.J.). 66: 497-507. PMID 24574208 DOI: 10.1002/Art.38268 |
0.351 |
|
| 2014 |
Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Moreland LW. Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation. American Journal of Epidemiology. 179: 917-26. PMID 24569640 DOI: 10.1093/Aje/Kwu003 |
0.375 |
|
| 2014 |
Holers VM. Complement and its receptors: new insights into human disease. Annual Review of Immunology. 32: 433-59. PMID 24499275 DOI: 10.1146/Annurev-Immunol-032713-120154 |
0.356 |
|
| 2014 |
Demoruelle MK, Deane KD, Holers VM. When and where does inflammation begin in rheumatoid arthritis? Current Opinion in Rheumatology. 26: 64-71. PMID 24247116 DOI: 10.1097/Bor.0000000000000017 |
0.387 |
|
| 2014 |
Borodovsky A, Yucius K, Sprague A, Banda NK, Holers VM, Vaishnaw A, Maier M, Kallanthottathil R, Charisse K, Kuchimanchi S, Manoharan M, Salant DJ, Fitzgerald K, Meyers R, Sorensen B. Aln-CC5, an Investigational RNAi Therapeutic Targeting C5 for Complement Inhibition Blood. 124: 1606-1606. DOI: 10.1182/Blood.V124.21.1606.1606 |
0.367 |
|
| 2013 |
Holers VM. Autoimmunity to citrullinated proteins and the initiation of rheumatoid arthritis. Current Opinion in Immunology. 25: 728-35. PMID 24215742 DOI: 10.1016/J.Coi.2013.09.018 |
0.404 |
|
| 2013 |
Willis VC, Demoruelle MK, Derber LA, Chartier-Logan CJ, Parish MC, Pedraza IF, Weisman MH, Norris JM, Holers VM, Deane KD. Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease Arthritis and Rheumatism. 65: 2545-2554. PMID 23817979 DOI: 10.1002/Art.38066 |
0.371 |
|
| 2013 |
Whitcup SM, Sodhi A, Atkinson JP, Holers VM, Sinha D, Rohrer B, Dick AD. The role of the immune response in age-related macular degeneration. International Journal of Inflammation. 2013: 348092. PMID 23762772 DOI: 10.1155/2013/348092 |
0.603 |
|
| 2013 |
Young KA, Deane KD, Derber LA, Hughes-Austin JM, Wagner CA, Sokolove J, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, Norris JM. Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis. Arthritis and Rheumatism. 65: 1995-2004. PMID 23754702 DOI: 10.1002/Art.38022 |
0.402 |
|
| 2013 |
Holers VM. Human C3 glomerulopathy provides unique insights into complement factor H-related protein function. The Journal of Clinical Investigation. 123: 2357-60. PMID 23728171 DOI: 10.1172/Jci69684 |
0.352 |
|
| 2013 |
Demoruelle MK, Parish MC, Derber LA, Kolfenbach JR, Hughes-Austin JM, Weisman MH, Gilliland W, Edison JD, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Norris JM, Holers VM, et al. Performance of anti-cyclic citrullinated Peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease. Arthritis and Rheumatism. 65: 2243-52. PMID 23686569 DOI: 10.1002/Art.38017 |
0.389 |
|
| 2013 |
Arend WP, Mehta G, Antonioli AH, Takahashi M, Takahashi K, Stahl GL, Holers VM, Banda NK. Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 6423-33. PMID 23650618 DOI: 10.4049/Jimmunol.1300580 |
0.423 |
|
| 2013 |
Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, Hourcade DE, Hannan JP, Kovacs JM, Coughlin B, Woodell AS, Pickering MC, Rohrer B, Holers VM. Detection of complement activation using monoclonal antibodies against C3d. The Journal of Clinical Investigation. 123: 2218-30. PMID 23619360 DOI: 10.1172/Jci65861 |
0.761 |
|
| 2013 |
Gan RW, Deane KD, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Holers VM, Norris JM. Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA. Annals of the Rheumatic Diseases. 72: 2002-5. PMID 23572338 DOI: 10.1136/Annrheumdis-2012-202949 |
0.353 |
|
| 2013 |
Keith RC, Sokolove J, Edelman BL, Lahey L, Redente EF, Holers VM, Sakaguchi S, Robinson WH, Riches DW. Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice. Arthritis and Rheumatism. 65: 1487-93. PMID 23529475 DOI: 10.1002/Art.37943 |
0.374 |
|
| 2013 |
Joseph K, Kulik L, Coughlin B, Kunchithapautham K, Bandyopadhyay M, Thiel S, Thielens NM, Holers VM, Rohrer B. Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. The Journal of Biological Chemistry. 288: 12753-65. PMID 23493397 DOI: 10.1074/Jbc.M112.421891 |
0.642 |
|
| 2013 |
Walitt B, Mackey R, Kuller L, Deane KD, Robinson W, Holers VM, Chang YF, Moreland L. Predictive value of autoantibody testing for validating self-reported diagnoses of rheumatoid arthritis in the Women's Health Initiative. American Journal of Epidemiology. 177: 887-93. PMID 23492764 DOI: 10.1093/Aje/Kws310 |
0.368 |
|
| 2013 |
Banda NK, Mehta G, Ferreira VP, Cortes C, Pickering MC, Pangburn MK, Arend WP, Holers VM. Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. Journal of Immunology (Baltimore, Md. : 1950). 190: 3560-9. PMID 23436934 DOI: 10.4049/Jimmunol.1203271 |
0.415 |
|
| 2013 |
Holers VM, Rohrer B, Tomlinson S. CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation. Advances in Experimental Medicine and Biology. 735: 137-54. PMID 23402024 DOI: 10.1007/978-1-4614-4118-2_9 |
0.657 |
|
| 2013 |
Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanović D, Holers VM, Thurman JM. IgM contributes to glomerular injury in FSGS. Journal of the American Society of Nephrology : Jasn. 24: 393-406. PMID 23393315 DOI: 10.1681/Asn.2012020187 |
0.429 |
|
| 2013 |
Hu X, Holers VM, Thurman JM, Schoeb TR, Ramos TN, Barnum SR. Therapeutic inhibition of the alternative complement pathway attenuates chronic EAE. Molecular Immunology. 54: 302-8. PMID 23337717 DOI: 10.1016/J.Molimm.2012.12.018 |
0.385 |
|
| 2013 |
Cordova KN, Willis VC, Haskins K, Holers VM. A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis. Journal of Immunology (Baltimore, Md. : 1950). 190: 1457-65. PMID 23319740 DOI: 10.4049/Jimmunol.1201517 |
0.787 |
|
| 2013 |
Liubchenko GA, Appleberry HC, Striebich CC, Franklin KE, Derber LA, Holers VM, Lyubchenko T. Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes. Journal of Autoimmunity. 40: 111-21. PMID 23058039 DOI: 10.1016/J.Jaut.2012.09.001 |
0.354 |
|
| 2013 |
Hughes-Austin JM, Deane KD, Derber LA, Kolfenbach JR, Zerbe GO, Sokolove J, Lahey LJ, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, et al. Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA). Annals of the Rheumatic Diseases. 72: 901-7. PMID 22915618 DOI: 10.1136/Annrheumdis-2012-201505 |
0.385 |
|
| 2013 |
Asokan R, Banda NK, Szakonyi G, Chen XS, Holers VM. Human complement receptor 2 (CR2/CD21) as a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE). Molecular Immunology. 53: 99-110. PMID 22885687 DOI: 10.1016/J.Molimm.2012.07.002 |
0.327 |
|
| 2013 |
Cataland SR, Holers VM, Yang S, Wu HM. Alternative and Terminal Complement Pathway Biomarkers At Presentation More Precisely Define The Clinical Diagnosis Of aHUS Blood. 122: 3552-3552. DOI: 10.1182/Blood.V122.21.3552.3552 |
0.32 |
|
| 2013 |
Rohrer B, Kulik L, Mitchell L, Hourcade D, Hannan J, Coughlin B, Woodell A, Pickering M, Holers V, Thurman J. Novel monoclonal antibodies to C3d for non-invasively monitoring the activity of complement in glomerular and retinal disease Molecular Immunology. 56: 264. DOI: 10.1016/J.Molimm.2013.05.073 |
0.588 |
|
| 2012 |
Mikuls TR, Thiele GM, Deane KD, Payne JB, O'Dell JR, Yu F, Sayles H, Weisman MH, Gregersen PK, Buckner JH, Keating RM, Derber LA, Robinson WH, Holers VM, Norris JM. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis and Rheumatism. 64: 3522-30. PMID 22736291 DOI: 10.1002/Art.34595 |
0.383 |
|
| 2012 |
Sokolove J, Bromberg R, Deane KD, Lahey LJ, Derber LA, Chandra PE, Edison JD, Gilliland WR, Tibshirani RJ, Norris JM, Holers VM, Robinson WH. Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. Plos One. 7: e35296. PMID 22662108 DOI: 10.1371/Journal.Pone.0035296 |
0.413 |
|
| 2012 |
Risitano AM, Notaro R, Pascariello C, Sica M, del Vecchio L, Horvath CJ, Fridkis-Hareli M, Selleri C, Lindorfer MA, Taylor RP, Luzzatto L, Holers VM. The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment. Blood. 119: 6307-16. PMID 22577173 DOI: 10.1182/Blood-2011-12-398792 |
0.385 |
|
| 2012 |
Thurman JM, Tchepeleva SN, Haas M, Panzer S, Boackle SA, Glogowska MJ, Quigg RJ, Holers VM. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. American Journal of Physiology. Renal Physiology. 302: F1529-36. PMID 22492944 DOI: 10.1152/Ajprenal.00422.2011 |
0.387 |
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| 2012 |
Li K, Gor J, Holers VM, Storek MJ, Perkins SJ. Solution structure of TT30, a novel complement therapeutic agent, provides insight into its joint binding to complement C3b and C3d. Journal of Molecular Biology. 418: 248-63. PMID 22387467 DOI: 10.1016/J.Jmb.2012.02.038 |
0.315 |
|
| 2012 |
Liubchenko GA, Appleberry HC, Holers VM, Banda NK, Willis VC, Lyubchenko T. Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile. Journal of Autoimmunity. 38: 293-303. PMID 22365785 DOI: 10.1016/J.Jaut.2011.12.005 |
0.318 |
|
| 2012 |
Weckbach S, Neher M, Losacco JT, Bolden AL, Kulik L, Flierl MA, Bell SE, Holers VM, Stahel PF. Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injury. Journal of Neurotrauma. 29: 1233-42. PMID 22335783 DOI: 10.1089/Neu.2011.2169 |
0.353 |
|
| 2012 |
Rohrer B, Coughlin B, Bandyopadhyay M, Holers VM. Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. 28: 402-9. PMID 22309197 DOI: 10.1089/Jop.2011.0212 |
0.633 |
|
| 2012 |
Banda NK, Hyatt S, Antonioli AH, White JT, Glogowska M, Takahashi K, Merkel TJ, Stahl GL, Mueller-Ortiz S, Wetsel R, Arend WP, Holers VM. Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. Journal of Immunology (Baltimore, Md. : 1950). 188: 1469-78. PMID 22205026 DOI: 10.4049/Jimmunol.1102310 |
0.386 |
|
| 2012 |
Elvington A, Atkinson C, Kulik L, Zhu H, Yu J, Kindy MS, Holers VM, Tomlinson S. Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice. Journal of Immunology (Baltimore, Md. : 1950). 188: 1460-8. PMID 22198950 DOI: 10.4049/Jimmunol.1102132 |
0.359 |
|
| 2012 |
Keith RC, Powers JL, Redente EF, Sergew A, Martin RJ, Gizinski A, Holers VM, Sakaguchi S, Riches DW. A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice. Experimental Lung Research. 38: 55-66. PMID 22185348 DOI: 10.3109/01902148.2011.636139 |
0.369 |
|
| 2012 |
Demoruelle MK, Weisman MH, Simonian PL, Lynch DA, Sachs PB, Pedraza IF, Harrington AR, Kolfenbach JR, Striebich CC, Pham QN, Strickland CD, Petersen BD, Parish MC, Derber LA, Norris JM, ... Holers VM, et al. Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis and Rheumatism. 64: 1756-61. PMID 22183986 DOI: 10.1002/Art.34344 |
0.379 |
|
| 2012 |
Takeda K, Thurman JM, Tomlinson S, Okamoto M, Shiraishi Y, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Gelfand EW. The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. Journal of Immunology (Baltimore, Md. : 1950). 188: 661-7. PMID 22174452 DOI: 10.4049/Jimmunol.1101813 |
0.374 |
|
| 2012 |
Pappworth IY, Hayes C, Dimmick J, Morgan BP, Holers VM, Marchbank KJ. Mice expressing human CR1/CD35 have an enhanced humoral immune response to T-dependent antigens but fail to correct the effect of premature human CR2 expression. Immunobiology. 217: 147-57. PMID 21783272 DOI: 10.1016/J.Imbio.2011.06.001 |
0.369 |
|
| 2012 |
Yang S, Cataland SR, Holers VM, Lundberg AS, Wu H. Complement Activation in Patients with Acquired Thrombotic Thrombocytopenic Pupura (TTP) Blood. 120: 3323-3323. DOI: 10.1182/Blood.V120.21.3323.3323 |
0.306 |
|
| 2012 |
Demoruelle K, Weisman M, Harrington A, Derber L, Kolfenbach J, Striebich C, Pedraza I, Lynch D, Sachs P, Petersen B, Strickland C, Norris J, Holers VM, Deane K. Lung abnormalities in subjects with elevations of rheumatoid arthritis-related autoantibodies without arthritis by examination and imaging suggest the lung is an early and perhaps initiating site of inflammation in rheumatoid arthritis Annals of the Rheumatic Diseases. 71: A25.1-A25. DOI: 10.1136/Annrheumdis-2011-201231.16 |
0.384 |
|
| 2011 |
Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, Crish JF, Bebek G, Ritter SY, Lindstrom TM, Hwang I, Wong HH, Punzi L, Encarnacion A, Shamloo M, ... ... Holers VM, et al. Identification of a central role for complement in osteoarthritis. Nature Medicine. 17: 1674-9. PMID 22057346 DOI: 10.1038/Nm.2543 |
0.39 |
|
| 2011 |
Banda NK, Takahashi M, Takahashi K, Stahl GL, Hyatt S, Glogowska M, Wiles TA, Endo Y, Fujita T, Holers VM, Arend WP. Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement. Molecular Immunology. 49: 281-9. PMID 21943708 DOI: 10.1016/J.Molimm.2011.08.021 |
0.39 |
|
| 2011 |
Fridkis-Hareli M, Storek M, Mazsaroff I, Risitano AM, Lundberg AS, Horvath CJ, Holers VM. Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases. Blood. 118: 4705-13. PMID 21860027 DOI: 10.1182/Blood-2011-06-359646 |
0.392 |
|
| 2011 |
Renner B, Ferreira VP, Cortes C, Goldberg R, Ljubanovic D, Pangburn MK, Pickering MC, Tomlinson S, Holland-Neidermyer A, Strassheim D, Holers VM, Thurman JM. Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney International. 80: 165-73. PMID 21544060 DOI: 10.1038/Ki.2011.115 |
0.326 |
|
| 2011 |
Willis VC, Gizinski AM, Banda NK, Causey CP, Knuckley B, Cordova KN, Luo Y, Levitt B, Glogowska M, Chandra P, Kulik L, Robinson WH, Arend WP, Thompson PR, Holers VM. N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. Journal of Immunology (Baltimore, Md. : 1950). 186: 4396-404. PMID 21346230 DOI: 10.4049/Jimmunol.1001620 |
0.79 |
|
| 2011 |
Kulik L, Chen K, Huber BT, Holers VM. Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists. Molecular Immunology. 48: 883-94. PMID 21269698 DOI: 10.1016/J.Molimm.2010.12.019 |
0.424 |
|
| 2011 |
Rohrer B, Coughlin B, Kunchithapautham K, Long Q, Tomlinson S, Takahashi K, Holers VM. The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. Molecular Immunology. 48: e1-8. PMID 21257205 DOI: 10.1016/J.Molimm.2010.12.016 |
0.63 |
|
| 2010 |
Shaw CD, Storek MJ, Young KA, Kovacs JM, Thurman JM, Holers VM, Hannan JP. Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking. Journal of Molecular Biology. 404: 697-710. PMID 20951140 DOI: 10.1016/J.Jmb.2010.10.005 |
0.653 |
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| 2010 |
Banda NK, Takahashi M, Levitt B, Glogowska M, Nicholas J, Takahashi K, Stahl GL, Fujita T, Arend WP, Holers VM. Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis. Journal of Immunology (Baltimore, Md. : 1950). 185: 5598-606. PMID 20870940 DOI: 10.4049/Jimmunol.1001564 |
0.443 |
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| 2010 |
Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM. B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion. Journal of Immunology (Baltimore, Md. : 1950). 185: 4393-400. PMID 20810984 DOI: 10.4049/Jimmunol.0903239 |
0.309 |
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| 2010 |
Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, Holers VM. A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. Advances in Experimental Medicine and Biology. 703: 137-49. PMID 20711712 DOI: 10.1007/978-1-4419-5635-4_10 |
0.636 |
|
| 2010 |
Renner B, Coleman K, Goldberg R, Amura C, Holland-Neidermyer A, Pierce K, Orth HN, Molina H, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Thurman JM. The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells. Journal of Immunology (Baltimore, Md. : 1950). 185: 3086-94. PMID 20675597 DOI: 10.4049/Jimmunol.1000111 |
0.368 |
|
| 2010 |
Deane KD, O'Donnell CI, Hueber W, Majka DS, Lazar AA, Derber LA, Gilliland WR, Edison JD, Norris JM, Robinson WH, Holers VM. The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner. Arthritis and Rheumatism. 62: 3161-72. PMID 20597112 DOI: 10.1002/Art.27638 |
0.36 |
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| 2010 |
Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair. The Journal of Biological Chemistry. 285: 27251-8. PMID 20558730 DOI: 10.1074/Jbc.M110.106617 |
0.651 |
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| 2010 |
Tan W, Wu H, Zhao J, Derber LA, Lee DM, Shadick NA, Conn DL, Smith EA, Gersuk VH, Nepom GT, Moreland LW, Furst DE, Thompson SD, Jonas BL, Holers VM, et al. A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis. Arthritis and Rheumatism. 62: 2864-75. PMID 20533289 DOI: 10.1002/Art.27589 |
0.352 |
|
| 2010 |
Deane KD, Norris JM, Holers VM. Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation. Rheumatic Diseases Clinics of North America. 36: 213-41. PMID 20510231 DOI: 10.1016/J.Rdc.2010.02.001 |
0.377 |
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| 2010 |
Ercan A, Cui J, Chatterton DE, Deane KD, Hazen MM, Brintnell W, O'Donnell CI, Derber LA, Weinblatt ME, Shadick NA, Bell DA, Cairns E, Solomon DH, Holers VM, Rudd PM, et al. Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis and Rheumatism. 62: 2239-48. PMID 20506563 DOI: 10.1002/Art.27533 |
0.389 |
|
| 2010 |
Kolfenbach JR, Deane KD, Derber LA, O'Donnell CI, Gilliland WR, Edison JD, Rosen A, Darrah E, Norris JM, Holers VM. Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arthritis and Rheumatism. 62: 2633-9. PMID 20496417 DOI: 10.1002/Art.27570 |
0.395 |
|
| 2010 |
Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, Thurman JM. Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice. Radiology. 255: 517-26. PMID 20332377 DOI: 10.1148/Radiol.09091134 |
0.302 |
|
| 2010 |
Thurman JM, Renner B, Kunchithapautham K, Holers VM, Rohrer B. Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. Advances in Experimental Medicine and Biology. 664: 151-8. PMID 20238013 DOI: 10.1007/978-1-4419-1399-9_18 |
0.615 |
|
| 2010 |
Fridkis-Hareli M, Storek M, Risitano AM, Lundberg AS, Horvath CJ, Holers VM. TT30, a Novel Human Complement Inhibitor in Development for Paroxysmal Nocturnal Hemoglobinuria and Other Hemolytic Disorders, Demonstrates Red Blood Cell Surface Targeting and Retention In a Model of Complement Alternative Pathway-Mediated Hemolysis Blood. 116: 638-638. DOI: 10.1182/Blood.V116.21.638.638 |
0.4 |
|
| 2010 |
Risitano AM, Pascariello C, Del Vecchio L, Horvath CJ, Fridkis-Hareli M, Holers VM, Lindorfer MA, Taylor RP. C3-Mediated Extravascular Hemolysis In Paroxysmal Nocturnal Hemoglobinuria: An In Vitro Model to Dissect Complement C3 Activation Comparing the Effects of Complement Inhibitors Eculizumab, 3E7 and TT30 on C3 Fragment Processing and Hemolysis of PNH Erythrocytes Blood. 116: 637-637. DOI: 10.1182/Blood.V116.21.637.637 |
0.333 |
|
| 2010 |
Banda NK, Takahashi M, Levitt B, Glogowska M, Nicholas J, Takahashi K, Stahl GL, Fujita T, Arend WP, Holers VM. Essential role of complement MASP-1/3 in the murine collagen antibody-induced model of inflammatory arthritis 1 Molecular Immunology. 47: 2269-2269. DOI: 10.1016/J.Molimm.2010.05.213 |
0.4 |
|
| 2010 |
Kovacs JM, Eisenmesser EZ, Hannan JP, Holers VM. Biophysical investigations of complement receptor 2 (CR2, CD21) ligand interactions reveal specific amino acid contacts unique to each receptor-ligand pair Molecular Immunology. 47: 2261-2261. DOI: 10.1016/J.Molimm.2010.05.190 |
0.634 |
|
| 2010 |
Storek MJ, Holers VM, Shaw CD, Young KA, Kovacs JM, Thurman JM, Hannan JP. Characterizing the complement receptor Type 2–C3d complex by site-directed mutagenesis and molecular modeling Molecular Immunology. 47: 2258-2258. DOI: 10.1016/J.Molimm.2010.05.181 |
0.623 |
|
| 2010 |
Risitano AM, Pascariello C, Selleri C, Vecchio LD, Sica M, Fridkis-Hareli M, Mazsaroff I, Horvath CJ, Holers VM. The human complement receptor type 2/factor H fusion protein TT30, an alternative pathway specific complement inhibitor, prevents hemolysis of erythrocytes from patients with paroxysmal nocturnal hemoglobinuria by membrane-targeting of factor H activity. Molecular Immunology. 47: 2215-2215. DOI: 10.1016/J.Molimm.2010.05.059 |
0.306 |
|
| 2009 |
Kolfenbach JR, Deane KD, Derber LA, O'Donnell C, Weisman MH, Buckner JH, Gersuk VH, Wei S, Mikuls TR, O'Dell J, Gregersen PK, Keating RM, Norris JM, Holers VM. A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA. Arthritis and Rheumatism. 61: 1735-42. PMID 19950324 DOI: 10.1002/Art.24833 |
0.365 |
|
| 2009 |
Deane KD, Striebich CC, Goldstein BL, Derber LA, Parish MC, Feser ML, Hamburger EM, Brake S, Belz C, Goddard J, Norris JM, Karlson EW, Holers VM. Identification of undiagnosed inflammatory arthritis in a community health fair screen. Arthritis and Rheumatism. 61: 1642-9. PMID 19950306 DOI: 10.1002/Art.24834 |
0.315 |
|
| 2009 |
Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, Tomlinson S, Arend WP, Holers VM. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 5928-37. PMID 19828624 DOI: 10.4049/Jimmunol.0901826 |
0.401 |
|
| 2009 |
Ricklin D, Tzekou A, Garcia BL, Hammel M, McWhorter WJ, Sfyroera G, Wu YQ, Holers VM, Herbert AP, Barlow PN, Geisbrecht BV, Lambris JD. A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. Journal of Immunology (Baltimore, Md. : 1950). 183: 2565-74. PMID 19625656 DOI: 10.4049/Jimmunol.0901443 |
0.338 |
|
| 2009 |
Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, Kastner DL, Seldin MF, Criswell LA, Plenge RM, Holers VM, Mikuls TR, Sokka T, Moreland LW, Bridges SL, Xie G, et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nature Genetics. 41: 820-3. PMID 19503088 DOI: 10.1038/Ng.395 |
0.302 |
|
| 2009 |
Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, Rohrer B. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. The Journal of Biological Chemistry. 284: 16939-47. PMID 19386604 DOI: 10.1074/Jbc.M808166200 |
0.626 |
|
| 2009 |
Kulik L, Fleming SD, Moratz C, Reuter JW, Novikov A, Chen K, Andrews KA, Markaryan A, Quigg RJ, Silverman GJ, Tsokos GC, Holers VM. Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury. Journal of Immunology (Baltimore, Md. : 1950). 182: 5363-73. PMID 19380783 DOI: 10.4049/Jimmunol.0803980 |
0.345 |
|
| 2009 |
Twohig JP, Pappworth IY, Sivasankar B, Kulik L, Bull M, Holers VM, Wang EC, Marchbank KJ. Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Molecular Immunology. 46: 2002-13. PMID 19359041 DOI: 10.1016/J.Molimm.2009.03.007 |
0.343 |
|
| 2009 |
Feser M, Derber LA, Deane KD, Lezotte DC, Weisman MH, Buckner JH, Mikuls T, O'Dell J, Gregersen PK, Holers VM, Norris JM. Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA. The Journal of Rheumatology. 36: 943-6. PMID 19286844 DOI: 10.3899/Jrheum.080764 |
0.343 |
|
| 2009 |
Gizinski AM, Mascolo M, Loucks JL, Kervitsky A, Meehan RT, Brown KK, Holers VM, Deane KD. Rheumatoid arthritis (RA)-specific autoantibodies in patients with interstitial lung disease and absence of clinically apparent articular RA. Clinical Rheumatology. 28: 611-3. PMID 19252818 DOI: 10.1007/S10067-009-1128-9 |
0.379 |
|
| 2009 |
Pappworth IY, Kulik L, Haluszczak C, Reuter JW, Holers VM, Marchbank KJ. Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21). Molecular Immunology. 46: 1042-9. PMID 19187965 DOI: 10.1016/J.Molimm.2008.08.273 |
0.387 |
|
| 2009 |
Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. Mapping of the C3d ligand binding site on complement receptor 2 (CR2/CD21) using nuclear magnetic resonance and chemical shift analysis. The Journal of Biological Chemistry. 284: 9513-20. PMID 19164292 DOI: 10.1074/Jbc.M808404200 |
0.661 |
|
| 2009 |
Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, Holers VM, Kuhn KA, O'Dell JR. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. International Immunopharmacology. 9: 38-42. PMID 18848647 DOI: 10.1016/J.Intimp.2008.09.008 |
0.632 |
|
| 2009 |
Holers VM, Mazsaroff I, Akana H, Smith CG, Emlen JW, Marians RC, Horvath CJ. TT30, a Novel Human Protein Therapeutic, Selectively Modulates the Complement Alternative Pathway by Targeted Supplementation of Local Factor H Activity. Blood. 114: 3021-3021. DOI: 10.1182/Blood.V114.22.3021.3021 |
0.405 |
|
| 2009 |
Risitano AM, Holers VM, Rotoli B. TT30, a Novel Regulator of the Complement Alternative Pathway (CAP), Inhibits Hemolysis of Paroxysmal Nocturnal Hemoglobinuria (PNH) Erythrocytes and Prevents Upstream C3 Binding On Their Surface in An in Vitro Model. Blood. 114: 158-158. DOI: 10.1182/Blood.V114.22.158.158 |
0.341 |
|
| 2009 |
Gastoldi S, Galbusera M, Emlen W, Holers VM, Banterla F, Donadelli R, Remuzzi G, Noris M. aHUS-associated genetic complement abnormalities cause C3 deposition on endothelial cells: Protective effects of specific inhibitors of the alternative pathway of complement Molecular Immunology. 46: 2850. DOI: 10.1016/J.Molimm.2009.05.273 |
0.308 |
|
| 2009 |
Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, Tomlinson S, Arend WP, Holers VM. Targeted inhibition of the alternative pathway of complement with complement receptor 2-factor H protein attenuates collagen antibody-induced arthritis in mice Molecular Immunology. 46: 2844. DOI: 10.1016/J.Molimm.2009.05.256 |
0.415 |
|
| 2008 |
Huang Y, Qiao F, Atkinson C, Holers VM, Tomlinson S. A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury. Journal of Immunology (Baltimore, Md. : 1950). 181: 8068-76. PMID 19017999 DOI: 10.4049/Jimmunol.181.11.8068 |
0.362 |
|
| 2008 |
Banda NK, Wood AK, Takahashi K, Levitt B, Rudd PM, Royle L, Abrahams JL, Stahl GL, Holers VM, Arend WP. Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies Arthritis and Rheumatism. 58: 3081-3089. PMID 18821684 DOI: 10.1002/Art.23865 |
0.367 |
|
| 2008 |
Li K, Okemefuna AI, Gor J, Hannan JP, Asokan R, Holers VM, Perkins SJ. Solution Structure of the Complex Formed between Human Complement C3d and Full-length Complement Receptor Type 2 Journal of Molecular Biology. 384: 137-150. PMID 18804116 DOI: 10.1016/J.Jmb.2008.08.084 |
0.319 |
|
| 2008 |
Holers VM. The spectrum of complement alternative pathway-mediated diseases Immunological Reviews. 223: 300-316. PMID 18613844 DOI: 10.1111/J.1600-065X.2008.00641.X |
0.379 |
|
| 2008 |
Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, Rudnick DA. Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Molecular Immunology. 45: 3125-32. PMID 18452991 DOI: 10.1016/J.Molimm.2008.03.008 |
0.334 |
|
| 2008 |
Kuhn KA, Cozine CL, Tomooka B, Robinson WH, Holers VM. Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens. Molecular Immunology. 45: 2808-19. PMID 18374982 DOI: 10.1016/J.Molimm.2008.01.036 |
0.664 |
|
| 2008 |
Zaiss AK, Cotter MJ, White LR, Clark SA, Wong NC, Holers VM, Bartlett JS, Muruve DA. Complement is an essential component of the immune response to adeno-associated virus vectors. Journal of Virology. 82: 2727-40. PMID 18199646 DOI: 10.1128/Jvi.01990-07 |
0.355 |
|
| 2008 |
Kulik L, Hannan JP, Huber BT, Holers VM. Treatment with a highly inhibitory monoclonal antibody directed to the C3d ligand binding site on human CR2/CD21 suppresses antigen-specific immune responses in vivo Molecular Immunology. 45: 4111-4112. DOI: 10.1016/J.Molimm.2008.08.050 |
0.35 |
|
| 2008 |
Kulik L, Fleming SD, Moratz C, Quigg RJ, Silverman GJ, Tsokos GC, Holers VM. Pathogenic natural antibodies recognizing Annexin IV are required to develop intestinal ischaemia-reperfusion injury and are selected during development in a CR2/CD21-dependent manner Molecular Immunology. 45: 4110. DOI: 10.1016/J.Molimm.2008.08.046 |
0.333 |
|
| 2007 |
Song H, Qiao F, Atkinson C, Holers VM, Tomlinson S. A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice. Journal of Immunology (Baltimore, Md. : 1950). 179: 7860-7. PMID 18025232 DOI: 10.4049/jimmunol.179.11.7860 |
0.431 |
|
| 2007 |
Young KA, Chen XS, Holers VM, Hannan JP. Isolating the Epstein-Barr virus gp350/220 binding site on complement receptor type 2 (CR2/CD21). The Journal of Biological Chemistry. 282: 36614-25. PMID 17925391 DOI: 10.1074/Jbc.M706324200 |
0.321 |
|
| 2007 |
Holers VM. Antibodies to citrullinated proteins: Pathogenic and diagnostic significance Current Rheumatology Reports. 9: 396-400. PMID 17915095 DOI: 10.1007/S11926-007-0063-5 |
0.399 |
|
| 2007 |
Banda NK, Takahashi K, Wood AK, Holers VM, Arend WP. Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway Journal of Immunology. 179: 4101-4109. PMID 17785849 DOI: 10.4049/Jimmunol.179.6.4101 |
0.426 |
|
| 2007 |
Lyubchenko T, Dal Porto JM, Holers VM, Cambier JC. Cutting edge: Complement (C3d)-linked antigens break B cell anergy Journal of Immunology. 179: 2695-2699. PMID 17709481 DOI: 10.4049/Jimmunol.179.5.2695 |
0.35 |
|
| 2007 |
Lenderink AM, Liegel K, Ljubanović D, Coleman KE, Gilkeson GS, Holers VM, Thurman JM. The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy American Journal of Physiology - Renal Physiology. 293. PMID 17522263 DOI: 10.1152/Ajprenal.00403.2006 |
0.367 |
|
| 2007 |
Mihai S, Chiriac MT, Takahashi K, Thurman JM, Holers VM, Zillikens D, Botto M, Sitaru C. The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita Journal of Immunology. 178: 6514-6521. PMID 17475881 DOI: 10.4049/Jimmunol.178.10.6514 |
0.374 |
|
| 2007 |
Leinhase I, Rozanski M, Harhausen D, Thurman JM, Schmidt OI, Hossini AM, Taha ME, Rittirsch D, Ward PA, Holers VM, Ertel W, Stahel PF. Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice. Journal of Neuroinflammation. 4: 13. PMID 17474994 DOI: 10.1186/1742-2094-4-13 |
0.39 |
|
| 2007 |
Twohig J, Kulik L, Haluszczak C, Reuter J, Rossbach A, Bull M, Holers VM, Marchbank KJ. Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3. Molecular Immunology. 44: 3434-44. PMID 17379312 DOI: 10.1016/J.Molimm.2007.02.011 |
0.352 |
|
| 2007 |
Kulik L, Marchbank KJ, Lyubchenko T, Kuhn KA, Liubchenko GA, Haluszczak C, Gipson MG, Gibson MG, Boackle SA, Holers VM. Intrinsic B cell hypo-responsiveness in mice prematurely expressing human CR2/CD21 during B cell development. European Journal of Immunology. 37: 623-33. PMID 17301948 DOI: 10.1002/Eji.200636248 |
0.64 |
|
| 2007 |
Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. Journal of Immunology (Baltimore, Md. : 1950). 178: 1819-28. PMID 17237432 DOI: 10.4049/Jimmunol.178.3.1819 |
0.331 |
|
| 2007 |
Thorgersen EB, Ghebremariam YT, Thurman JM, Fung M, Nielsen EW, Holers VM, Kotwal GJ, Mollnes TE. Candidate inhibitors of porcine complement. Molecular Immunology. 44: 1827-34. PMID 17109963 DOI: 10.1016/J.Molimm.2006.10.004 |
0.349 |
|
| 2007 |
Holers VM, Kulik L. Complement receptor 2, natural antibodies and innate immunity: Inter-relationships in B cell selection and activation Molecular Immunology. 44: 64-72. PMID 16876864 DOI: 10.1016/J.Molimm.2006.07.003 |
0.394 |
|
| 2007 |
Mihai S, Chiriac MT, Takahashi K, Thurman JM, Holers VM, Zillikens D, Botto M, Sitaru C. The alternative pathway of complement activation is critical for blister induction in experimental autoimmune epidermolysis bullosa Molecular Immunology. 44: 3913. DOI: 10.1016/J.Molimm.2007.06.017 |
0.319 |
|
| 2007 |
Holers VM, Wood A, Takahashi K, Ezekowitz AB, Arend WP, Banda NK. The alternative pathway is both necessary and sufficient for the complement-dependent injury found in the effector phase of collagen antibody induced arthritis (CAIA) Molecular Immunology. 44: 3913. DOI: 10.1016/J.Molimm.2007.06.016 |
0.357 |
|
| 2007 |
Wood A, Banda NK, Takahashi K, Ezekowitz AB, Arend WP, Holers VM. The lectin pathway of complement activation participates in the passive transfer model of collagen-induced arthritis Molecular Immunology. 44: 257-258. DOI: 10.1016/J.Molimm.2006.07.260 |
0.341 |
|
| 2007 |
Kulik L, Holers VM, Marchbank KJ. Defective B cell ontogeny and immune response are partially reversed in aging human complement receptor 2 (CR2, CD21) transgenic mice Molecular Immunology. 44: 200. DOI: 10.1016/J.Molimm.2006.07.125 |
0.358 |
|
| 2007 |
Kuhn KA, Holers VM. Protection from collagen-induced arthritis by complement receptor CR2/CR1 deficiency Molecular Immunology. 44: 199. DOI: 10.1016/J.Molimm.2006.07.123 |
0.615 |
|
| 2007 |
Cruikshank MN, Fenwick EJ, Dods J, Holers VM, Abraham LJ, Ulgiati D. Tandem E box motifs control complement receptor 2 (CR2/CD21) promoter activity via a novel repressor protein and chromatin accessibility Molecular Immunology. 44: 162. DOI: 10.1016/J.Molimm.2006.07.039 |
0.317 |
|
| 2007 |
Atkinson C, Kulik L, Zhu H, Yu J, Kindy MS, Holers VM, Tomlinson S. Pathogenic natural IgM antibodies recognizing different antigens mediate injury following ischemic stroke in Rag1−/− mice Molecular Immunology. 44: 153. DOI: 10.1016/J.Molimm.2006.07.019 |
0.306 |
|
| 2006 |
Gilbert HE, Asokan R, Holers VM, Perkins SJ. The 15 SCR Flexible Extracellular Domains of Human Complement Receptor Type 2 can Mediate Multiple Ligand and Antigen Interactions Journal of Molecular Biology. 362: 1132-1147. PMID 16950392 DOI: 10.1016/J.Jmb.2006.08.012 |
0.329 |
|
| 2006 |
Mikuls TR, Holers VM, Parrish L, Kuhn KA, Conn DL, Gilkeson G, Smith EA, Kamen DL, Jonas BL, Callahan LF, Alarcón GS, Howard G, Moreland LW, Bridges SL. Anti-cyclic citrullinated peptide antibody and rheumatoid factor isotypes in African Americans with early rheumatoid arthritis. Arthritis and Rheumatism. 54: 3057-9. PMID 16948136 DOI: 10.1002/Art.22200 |
0.63 |
|
| 2006 |
Holers VM. Are anti-cyclic citrullinated peptide antibodies pathogenic in rheumatoid arthritis? Nature Clinical Practice Rheumatology. 2: 400-401. PMID 16932728 DOI: 10.1038/Ncprheum0247 |
0.383 |
|
| 2006 |
Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction Journal of Experimental Medicine. 203: 2165-2175. PMID 16923853 DOI: 10.1084/Jem.20061022 |
0.316 |
|
| 2006 |
Banda NK, Thurman JM, Kraus D, Wood A, Carroll MC, Arend WP, Holers VM. Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis Journal of Immunology. 177: 1904-1912. PMID 16849503 DOI: 10.4049/Jimmunol.177.3.1904 |
0.431 |
|
| 2006 |
Leinhase I, Holers VM, Thurman JM, Harhausen D, Schmidt OI, Pietzcker M, Taha ME, Rittirsch D, Huber-Lang M, Smith WR, Ward PA, Stahel PF. Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation. Bmc Neuroscience. 7: 55. PMID 16842619 DOI: 10.1186/1471-2202-7-55 |
0.327 |
|
| 2006 |
Asokan R, Hua J, Young KA, Gould HJ, Hannan JP, Kraus DM, Szakonyi G, Grundy GJ, Chen XS, Crow MK, Holers VM. Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus. Journal of Immunology (Baltimore, Md. : 1950). 177: 383-94. PMID 16785534 DOI: 10.4049/Jimmunol.177.1.383 |
0.335 |
|
| 2006 |
Taube C, Thurman JM, Takeda K, Joetham A, Miyahara N, Carroll MC, Dakhama A, Giclas PC, Holers VM, Gelfand EW. Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation. Proceedings of the National Academy of Sciences of the United States of America. 103: 8084-9. PMID 16702544 DOI: 10.1073/Pnas.0602357103 |
0.36 |
|
| 2006 |
Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, Holers VM. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. The Journal of Clinical Investigation. 116: 961-73. PMID 16585962 DOI: 10.1172/Jci25422 |
0.665 |
|
| 2006 |
Leinhase I, Schmidt OI, Thurman JM, Hossini AM, Rozanski M, Taha ME, Scheffler A, John T, Smith WR, Holers VM, Stahel PF. Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury. Experimental Neurology. 199: 454-64. PMID 16545803 DOI: 10.1016/J.Expneurol.2006.01.033 |
0.356 |
|
| 2006 |
Thurman JM, Royer PA, Ljubanovic D, Dursun B, Lenderink AM, Edelstein CL, Holers VM. Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury Journal of the American Society of Nephrology. 17: 707-715. PMID 16467447 DOI: 10.1681/Asn.2005070698 |
0.345 |
|
| 2006 |
Thurman JM, Ljubanović D, Royer PA, Kraus DM, Molina H, Barry NP, Proctor G, Levi M, Holers VM. Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion Journal of Clinical Investigation. 116: 357-368. PMID 16444293 DOI: 10.1172/Jci24521 |
0.336 |
|
| 2006 |
Thurman JM, Holers VM. The central role of the alternative complement pathway in human disease Journal of Immunology. 176: 1305-1310. PMID 16424154 DOI: 10.4049/Jimmunol.176.3.1305 |
0.368 |
|
| 2006 |
Gilbert HE, Aslam M, Guthridge JM, Holers VM, Perkins SJ. Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: Implications for function and therapy Journal of Molecular Biology. 356: 397-412. PMID 16375923 DOI: 10.1016/J.Jmb.2005.11.050 |
0.303 |
|
| 2006 |
Robinson W, Kuhn K, Tomooka B, Holers VM, Ho P. OR.35. Fibrinogen-Induced Arthritis in Mice As a Model for Rheumatoid Arthritis Clinical Immunology. 119: S16-S17. DOI: 10.1016/J.Clim.2006.04.037 |
0.65 |
|
| 2005 |
Hibbert RG, Teriete P, Grundy GJ, Beavil RL, Reljic R, Holers VM, Hannan JP, Sutton BJ, Gould HJ, McDonnell JM. The structure of human CD23 and its interactions with IgE and CD21. The Journal of Experimental Medicine. 202: 751-60. PMID 16172256 DOI: 10.1084/Jem.20050811 |
0.318 |
|
| 2005 |
Atkinson C, Song H, Lu B, Qiao F, Burns TA, Holers VM, Tsokos GC, Tomlinson S. Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. The Journal of Clinical Investigation. 115: 2444-53. PMID 16127466 DOI: 10.1172/Jci25208 |
0.358 |
|
| 2005 |
Birrell L, Kulik L, Morgan BP, Holers VM, Marchbank KJ. B cells from mice prematurely expressing human complement receptor type 2 are unresponsive to T-dependent antigens Journal of Immunology. 174: 6974-6982. PMID 15905540 DOI: 10.4049/Jimmunol.174.11.6974 |
0.364 |
|
| 2005 |
Lyubchenko T, Dal Porto J, Cambier JC, Holers VM. Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: Activation without engagement of an inhibitory signaling pathway Journal of Immunology. 174: 3264-3272. PMID 15749857 DOI: 10.4049/Jimmunol.174.6.3264 |
0.37 |
|
| 2005 |
Hannan JP, Young KA, Guthridge JM, Asokan R, Szakonyi G, Chen XS, Holers VM. Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d. Journal of Molecular Biology. 346: 845-58. PMID 15713467 DOI: 10.1016/J.Jmb.2004.12.007 |
0.354 |
|
| 2005 |
Thurman JM, Lucia MS, Ljubanovic D, Holers VM. Acute tubular necrosis is characterized by activation of the alternative pathway of complement Kidney International. 67: 524-530. PMID 15673300 DOI: 10.1111/J.1523-1755.2005.67109.X |
0.345 |
|
| 2005 |
Ferucci ED, Majka DS, Parrish LA, Moroldo MB, Ryan M, Passo M, Thompson SD, Deane KD, Rewers M, Arend WP, Glass DN, Norris JM, Holers VM. Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. Arthritis and Rheumatism. 52: 239-46. PMID 15641089 DOI: 10.1002/Art.20773 |
0.369 |
|
| 2005 |
Holers VM. Complement receptors and the shaping of the natural antibody repertoire Springer Seminars in Immunopathology. 26: 405-423. PMID 15614507 DOI: 10.1007/S00281-004-0186-Y |
0.41 |
|
| 2005 |
Thurman JM, Kraus DM, Girardi G, Hourcade D, Kang HJ, Royer PA, Mitchell LM, Giclas PC, Salmon J, Gilkeson G, Holers VM. A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice Molecular Immunology. 42: 87-97. PMID 15488947 DOI: 10.1016/J.Molimm.2004.07.043 |
0.401 |
|
| 2004 |
Fleming SD, Egan RP, Chai C, Girardi G, Holers VM, Salmon J, Monestier M, Tsokos GC. Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 173: 7055-61. PMID 15557203 DOI: 10.4049/Jimmunol.173.11.7055 |
0.361 |
|
| 2004 |
Holers VM. Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus Journal of Clinical Investigation. 114: 616-619. PMID 15343378 DOI: 10.1172/Jci22820 |
0.381 |
|
| 2004 |
Boackle SA, Culhane KK, Brown JM, Haas M, Bao L, Quigg RJ, Holers VM. CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE. Autoimmunity. 37: 111-23. PMID 15293881 DOI: 10.1080/08916930410001685063 |
0.356 |
|
| 2004 |
Ohta R, Kondor N, Dohi N, Tomlinson S, Imai M, Holers VM, Okada H, Okada N. Mouse complement receptor-related gene y/p65-neutralized tumor vaccine induces antitumor activity in vivo. Journal of Immunology (Baltimore, Md. : 1950). 173: 205-13. PMID 15210776 DOI: 10.4049/Jimmunol.173.1.205 |
0.306 |
|
| 2004 |
Holers VM, Thurman JM. The alternative pathway of complement in disease: Opportunities for therapeutic targeting Molecular Immunology. 41: 147-152. PMID 15159060 DOI: 10.1016/J.Molimm.2004.03.012 |
0.374 |
|
| 2004 |
Mühlfeld AS, Segerer S, Hudkins K, Farr AG, Bao L, Kraus D, Holers VM, Quigg RJ, Alpers CE. Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis. Kidney International. 65: 1214-23. PMID 15086460 DOI: 10.1111/J.1523-1755.2004.00495.X |
0.385 |
|
| 2004 |
Elliott MK, Jarmi T, Ruiz P, Xu Y, Holers VM, Gilkeson GS. Effects of complement factor D deficiency on the renal disease of MRL/lpr mice Kidney International. 65: 129-138. PMID 14675043 DOI: 10.1111/J.1523-1755.2004.00371.X |
0.359 |
|
| 2003 |
Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. The Journal of Clinical Investigation. 112: 1644-54. PMID 14660741 DOI: 10.1172/Jci18817 |
0.328 |
|
| 2003 |
Alexander JJ, Bao L, Jacob A, Kraus DM, Holers VM, Quigg RJ. Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. Biochimica Et Biophysica Acta. 1639: 169-76. PMID 14636948 DOI: 10.1016/J.Bbadis.2003.09.005 |
0.326 |
|
| 2003 |
Bao L, Zhou J, Holers VM, Quigg RJ. Excessive matrix accumulation in the kidneys of MRL/lpr lupus mice is dependent on complement activation. Journal of the American Society of Nephrology : Jasn. 14: 2516-25. PMID 14514729 DOI: 10.1097/01.Asn.0000089831.96794.0B |
0.362 |
|
| 2003 |
Taube C, Rha YH, Takeda K, Park JW, Joetham A, Balhorn A, Dakhama A, Giclas PC, Holers VM, Gelfand EW. Inhibition of complement activation decreases airway inflammation and hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine. 168: 1333-41. PMID 14500265 DOI: 10.1164/Rccm.200306-739Oc |
0.318 |
|
| 2003 |
Banda NK, Kraus DM, Muggli M, Bendele A, Holers VM, Arend WP. Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein y Journal of Immunology. 171: 2109-2115. PMID 12902517 DOI: 10.4049/Jimmunol.171.4.2109 |
0.365 |
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| 2003 |
Song H, He C, Knaak C, Guthridge JM, Holers VM, Tomlinson S. Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation. The Journal of Clinical Investigation. 111: 1875-85. PMID 12813023 DOI: 10.1172/Jci17348 |
0.384 |
|
| 2003 |
Bao L, Haas M, Kraus DM, Hack BK, Rakstang JK, Holers VM, Quigg RJ. Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice. Journal of the American Society of Nephrology : Jasn. 14: 670-9. PMID 12595503 DOI: 10.1097/01.Asn.0000051597.27127.A1 |
0.373 |
|
| 2003 |
Thurman JM, Ljubanovic D, Edelstein CL, Gilkeson GS, Holers VM. Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice Journal of Immunology. 170: 1517-1523. PMID 12538716 DOI: 10.4049/Jimmunol.170.3.1517 |
0.323 |
|
| 2002 |
Banda NK, Kraus D, Vondracek A, Huynh LH, Bendele A, Holers VM, Arend WP. Mechanisms of effects of complement inhibition in murine collagen-induced arthritis. Arthritis and Rheumatism. 46: 3065-75. PMID 12428251 DOI: 10.1002/Art.10591 |
0.383 |
|
| 2002 |
Marchbank KJ, Kulik L, Gipson MG, Morgan BP, Holers VM. Expression of human complement receptor type 2 (CD21) in mice during early B cell development results in a reduction in mature B cells and hypogammaglobulinemia Journal of Immunology. 169: 3526-3535. PMID 12244142 DOI: 10.4049/Jimmunol.169.7.3526 |
0.362 |
|
| 2002 |
Fleming SD, Shea-Donohue T, Guthridge JM, Kulik L, Waldschmidt TJ, Gipson MG, Tsokos GC, Holers VM. Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire. Journal of Immunology (Baltimore, Md. : 1950). 169: 2126-33. PMID 12165541 DOI: 10.4049/Jimmunol.169.4.2126 |
0.362 |
|
| 2002 |
Ulgiati D, Pham C, Holers VM. Functional analysis of the human complement receptor 2 (CR2/CD21) promoter: Characterization of Basal transcriptional mechanisms Journal of Immunology. 168: 6279-6285. PMID 12055242 DOI: 10.4049/Jimmunol.168.12.6279 |
0.326 |
|
| 2002 |
Bao L, Haas M, Boackle SA, Kraus DM, Cunningham PN, Park P, Alexander JJ, Anderson RK, Culhane K, Holers VM, Quigg RJ. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. Journal of Immunology (Baltimore, Md. : 1950). 168: 3601-7. PMID 11907125 DOI: 10.4049/Jimmunol.168.7.3601 |
0.345 |
|
| 2002 |
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, et al. Arthritis critically dependent on innate immune system players. Immunity. 16: 157-68. PMID 11869678 DOI: 10.1016/S1074-7613(02)00275-3 |
0.434 |
|
| 2002 |
Holers VM, Girardi G, Mo L, Guthridge JM, Molina H, Pierangeli SS, Espinola R, Xiaowei LE, Mao D, Vialpando CG, Salmon JE. Complement C3 activation is required for antiphospholipid antibody-induced fetal loss. The Journal of Experimental Medicine. 195: 211-20. PMID 11805148 DOI: 10.1084/Jem.200116116 |
0.372 |
|
| 2001 |
Ulgiati D, Holers VM. CR2/CD21 proximal promoter activity is critically dependent on a cell type-specific repressor Journal of Immunology. 167: 6912-6919. PMID 11739509 DOI: 10.4049/Jimmunol.167.12.6912 |
0.324 |
|
| 2001 |
Boackle SA, Holers VM, Chen X, Szakonyi G, Karp DR, Wakeland EK, Morel L. Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein Immunity. 15: 775-785. PMID 11728339 DOI: 10.1016/S1074-7613(01)00228-X |
0.349 |
|
| 2001 |
Rehrig S, Fleming SD, Anderson J, Guthridge JM, Rakstang J, McQueen CE, Holers VM, Tsokos GC, Shea-Donohue T. Complement inhibitor, complement receptor 1-related gene/protein y-Ig attenuates intestinal damage after the onset of mesenteric ischemia/reperfusion injury in mice Journal of Immunology. 167: 5921-5927. PMID 11698469 DOI: 10.4049/Jimmunol.167.10.5921 |
0.342 |
|
| 2001 |
Guthridge JM, Young K, Gipson MG, Sarrias MR, Szakonyi G, Chen XS, Malaspina A, Donoghue E, James JA, Lambris JD, Moir SA, Perkins SJ, Holers VM. Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: Identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface Journal of Immunology. 167: 5758-5766. PMID 11698449 DOI: 10.4049/Jimmunol.167.10.5758 |
0.354 |
|
| 2001 |
Henson SE, Smith D, Boackle SA, Holers VM, Karp DR. Generation of recombinant human C3dg tetramers for the analysis of CD21 binding and function Journal of Immunological Methods. 258: 97-109. PMID 11684127 DOI: 10.1016/S0022-1759(01)00471-9 |
0.361 |
|
| 2001 |
Kaya Z, Afanasyeva M, Wang Y, Dohmen KM, Schlichting J, Tretter T, Fairweather D, Holers VM, Rose NR. Contribution of the innate immune system to autoimmune myocarditis: a role for complement. Nature Immunology. 2: 739-45. PMID 11477411 DOI: 10.1038/90686 |
0.351 |
|
| 2001 |
Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS. Structure of complement receptor 2 in complex with its C3d ligand Science. 292: 1725-1728. PMID 11387479 DOI: 10.1126/Science.1059118 |
0.324 |
|
| 2001 |
Guthridge JM, Rakstang JK, Young KA, Hinshelwood J, Aslam M, Robertson A, Gipson MG, Sarrias MR, Moore WT, Meagher M, Karp D, Lambris JD, Perkins SJ, Holers VM. Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg. Biochemistry. 40: 5931-41. PMID 11352728 DOI: 10.1021/Bi0101749 |
0.315 |
|
| 2001 |
Sekine H, Reilly CM, Molano ID, Garnier G, Circolo A, Ruiz P, Holers VM, Boackle SA, Gilkeson GS. Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice Journal of Immunology. 166: 6444-6451. PMID 11342671 DOI: 10.4049/Jimmunol.166.10.6444 |
0.377 |
|
| 2001 |
Makar KW, Ulgiati D, Hagman J, Holers VM. A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation International Immunology. 13: 657-664. PMID 11312253 DOI: 10.1093/Intimm/13.5.657 |
0.351 |
|
| 2000 |
Cunningham PN, Holers VM, Alexander JJ, Guthridge JM, Carroll MC, Quigg RJ. Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure Kidney International. 58: 1580-1587. PMID 11012892 DOI: 10.1046/J.1523-1755.2000.00319.X |
0.303 |
|
| 2000 |
Marchbank KJ, Watson CC, Ritsema DF, Holers VM. Expression of human complement receptor 2 (CR2, CD21) in Cr2(-/-) mice restores humoral immune function Journal of Immunology. 165: 2354-2361. PMID 10946257 DOI: 10.4049/Jimmunol.165.5.2354 |
0.369 |
|
| 2000 |
Holers VM. Phenotypes of complement knockouts Immunopharmacology. 49: 125-131. PMID 10904112 DOI: 10.1016/S0162-3109(00)80298-2 |
0.335 |
|
| 2000 |
Xu C, Mao D, Holers VM, Palanca B, Cheng AM, Molina H. A critical role for murine complement regulator Crry in fetomaternal tolerance Science. 287: 498-501. PMID 10642554 DOI: 10.1126/Science.287.5452.498 |
0.351 |
|
| 2000 |
Watanabe H, Garnier G, Circolo A, Wetsel RA, Ruiz P, Holers VM, Boackle SA, Colten HR, Gilkeson GS. Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B. Journal of Immunology (Baltimore, Md. : 1950). 164: 786-94. PMID 10623824 DOI: 10.4049/Jimmunol.164.2.786 |
0.377 |
|
| 2000 |
Lambris JD, Holers VM. Therapeutic Interventions in the Complement System Trends in Immunology. 22: 58. DOI: 10.1385/1592590179 |
0.35 |
|
| 1999 |
Karp DR, Carlisle ML, Mobley AB, Nichols TC, Oppenheimer-Marks N, Brezinschek RI, Holers VM. Gamma-glutamyl transpeptidase is up-regulated on memory T lymphocytes. International Immunology. 11: 1791-800. PMID 10545483 DOI: 10.1093/Intimm/11.11.1791 |
0.303 |
|
| 1999 |
Alexander JJ, Lim A, He C, MacDonald RL, Holers VM, Quigg RJ. Renal, central nervous system and pancreatic overexpression of recombinant soluble Crry in transgenic mice. A novel means of protection from complement-mediated injury Immunopharmacology. 42: 245-254. PMID 10408385 DOI: 10.1016/S0162-3109(99)00010-7 |
0.387 |
|
| 1999 |
Nardin A, Schlimgen R, Holers VM, Taylor RP. A prototype pathogen bound ex vivo to human erythrocyte complement receptor 1 via bispecific monoclonal antibody complexes is cleared to the liver in a mouse model European Journal of Immunology. 29: 1581-1586. PMID 10359112 DOI: 10.1002/(Sici)1521-4141(199905)29:05<1581::Aid-Immu1581>3.0.Co;2-V |
0.327 |
|
| 1998 |
Nichols TC, Guthridge JM, Karp DR, Molina H, Fletcher DR, Holers VM. γ-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes European Journal of Immunology. 28: 4123-4129. PMID 9862348 DOI: 10.1002/(Sici)1521-4141(199812)28:12<4123::Aid-Immu4123>3.0.Co;2-G |
0.303 |
|
| 1998 |
Quigg RJ, He C, Lim A, Berthiaume D, Alexander JJ, Kraus D, Holers VM. Transgenic mice overexpressing the complement inhibitor Crry as a soluble protein are protected from antibody-induced glomerular injury Journal of Experimental Medicine. 188: 1321-1331. PMID 9763611 DOI: 10.1084/Jem.188.7.1321 |
0.349 |
|
| 1998 |
Quigg RJ, Kozono Y, Berthiaume D, Lim A, Salant DJ, Weinfeld A, Griffin P, Kremmer E, Holers VM. Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor. Journal of Immunology (Baltimore, Md. : 1950). 160: 4553-60. PMID 9574562 |
0.307 |
|
| 1998 |
Holers VM. Complement receptor type 2 (CR2/CD21) as a central link between innate and acquired immunity Clinical Immunology Newsletter. 18: 7-10. DOI: 10.1016/S0197-1859(00)89165-7 |
0.356 |
|
| 1998 |
Quigg RJ, Lim A, Schiller B, He C, Berthiaume D, Alexander JJ, Kraus D, Holers V. Transgenic mice overexpressing CRRY as a recombinant soluble protein are protected from complement-mediated renal injury Molecular Immunology. 35: 395. DOI: 10.1016/S0161-5890(98)90789-1 |
0.315 |
|
| 1998 |
Watanabe H, Circolo A, Wetsel R, Holers V, Boackle SA, Colten HR, Gilkeson GS. Amelioration of renal disease in lupus mice genetically deficient in complement factor B Molecular Immunology. 35: 336. DOI: 10.1016/S0161-5890(98)90556-9 |
0.309 |
|
| 1998 |
Gilkeson GS, Garnier G, Circolo A, Wetsel R, Holers V, Feagin A, Colten HR. Modulation of renal disease in lupus mice deficient in complement component C3 Molecular Immunology. 35: 336. DOI: 10.1016/S0161-5890(98)90555-7 |
0.32 |
|
| 1997 |
Kearns-Jonker M, Monell-Torrens E, Abbasi F, Holers VM, Notkins AL, Sigounas G. EBV binds to lymphocytes of transgenic mice that express the human CR2 gene. Virus Research. 50: 85-94. PMID 9255938 DOI: 10.1016/S0168-1702(97)00052-X |
0.315 |
|
| 1997 |
Alexander JJ, He C, Adler S, Holers VM, Quigg RJ. Characterization of C3 receptors on cultured rat glomerular endothelial cells Kidney International. 51: 1124-1132. PMID 9083278 DOI: 10.1038/Ki.1997.155 |
0.34 |
|
| 1997 |
Boackle SA, Holers VM, Karp DR. CD21 augments antigen presentation in immune individuals European Journal of Immunology. 27: 122-129. PMID 9022008 DOI: 10.1002/Eji.1830270119 |
0.358 |
|
| 1995 |
Kozono Y, Duke RC, Schleicher MS, Holers VM. Co-ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI-231 cells from anti-surface IgM-induced apoptosis European Journal of Immunology. 25: 1013-1017. PMID 7737272 DOI: 10.1002/Eji.1830250423 |
0.363 |
|
| 1995 |
Quigg RJ, Morgan BP, Holers VM, Adler S, Sneed AE, Lo CF. Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells Kidney International. 48: 412-421. PMID 7564108 DOI: 10.1038/Ki.1995.309 |
0.357 |
|
| 1993 |
Foley S, Li B, Dehoff M, Molina H, Holers VM. Mouse Crry/p65 is a regulator of the alternative pathway of complement activation European Journal of Immunology. 23: 1381-1384. PMID 8500531 DOI: 10.1002/Eji.1830230630 |
0.338 |
|
| 1985 |
Holers VM, Cole JL, Lublin DM, Seya T, Atkinson JP. Human C3b- and C4b-regulatory proteins: a new multi-gene family. Immunology Today. 6: 188-92. PMID 25289982 DOI: 10.1016/0167-5699(85)90114-8 |
0.322 |
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