Year |
Citation |
Score |
2023 |
Lu J, Pan Y, Feng X, Lu B. Phase transition and lysosomal degradation of expanded CAG repeat RNA suppress global protein synthesis. Autophagy. 1-3. PMID 37876230 DOI: 10.1080/15548627.2023.2274208 |
0.651 |
|
2023 |
Pan Y, Lu J, Feng X, Lu S, Yang Y, Yang G, Tan S, Wang L, Li P, Luo S, Lu B. Gelation of cytoplasmic expanded CAG RNA repeats suppresses global protein synthesis. Nature Chemical Biology. PMID 37592155 DOI: 10.1038/s41589-023-01384-5 |
0.654 |
|
2022 |
Long J, Luo X, Fang D, Song H, Fang W, Shan H, Liu P, Lu B, Yin XM, Hong L, Li M. Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington's disease-related phenotype. Cell & Bioscience. 12: 167. PMID 36209136 DOI: 10.1186/s13578-022-00906-3 |
0.327 |
|
2021 |
Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. Author Correction: A growth-factor-activated lysosomal K channel regulates Parkinson's pathology. Nature. PMID 33790472 DOI: 10.1038/s41586-021-03438-x |
0.615 |
|
2021 |
Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. A growth-factor-activated lysosomal K channel regulates Parkinson's pathology. Nature. PMID 33505021 DOI: 10.1038/s41586-021-03185-z |
0.658 |
|
2021 |
Li XJ, Zhang YY, Fu YH, Zhang H, Li HX, Li QF, Li HL, Tan RK, Jiang CX, Jiang W, Li ZX, Luo C, Lu BX, Dang YJ. Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex. Acta Pharmacologica Sinica. PMID 33495516 DOI: 10.1038/s41401-020-00605-0 |
0.311 |
|
2020 |
Ding Y, Fei Y, Lu B. Emerging New Concepts of Degrader Technologies. Trends in Pharmacological Sciences. PMID 32416934 DOI: 10.1016/J.Tips.2020.04.005 |
0.3 |
|
2019 |
Roberts SL, Evans T, Yang Y, Fu Y, Button RW, Sipthorpe RJ, Cowan K, Valionyte E, Anichtchik O, Li H, Lu B, Luo S. Bim contributes to the progression of Huntington's disease-associated phenotypes. Human Molecular Genetics. PMID 31813995 DOI: 10.1093/hmg/ddz275 |
0.308 |
|
2019 |
Valionyte E, Yang Y, Roberts SL, Kelly J, Lu B, Luo S. Lowering mutant huntingtin levels and toxicity: autophagy-endolysosome pathways in Huntington's disease. Journal of Molecular Biology. PMID 31786267 DOI: 10.1016/J.Jmb.2019.11.012 |
0.396 |
|
2019 |
Li Z, Zhu C, Ding Y, Fei Y, Lu B. ATTEC: a potential new approach to target proteinopathies. Autophagy. PMID 31690177 DOI: 10.1080/15548627.2019.1688556 |
0.415 |
|
2019 |
Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, ... ... Lu B, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. PMID 31666698 DOI: 10.1038/S41586-019-1722-1 |
0.563 |
|
2018 |
Feng X, Luo S, Lu B. Conformation Polymorphism of Polyglutamine Proteins. Trends in Biochemical Sciences. PMID 29636213 DOI: 10.1016/J.Tibs.2018.03.002 |
0.671 |
|
2018 |
Song H, Li H, Guo S, Pan Y, Fu Y, Zhou Z, Li Z, Wen X, Sun X, He B, Gu H, Zhao Q, Wang C, An P, Luo S, ... ... Lu B, et al. Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes. Brain : a Journal of Neurology. PMID 29608652 DOI: 10.1093/Brain/Awy081 |
0.389 |
|
2017 |
Yu M, Fu Y, Liang Y, Song H, Yao Y, Wu P, Yao Y, Pan Y, Wen X, Ma L, Hexige S, Ding Y, Luo S, Lu B. Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models. Cell Research. PMID 29151587 DOI: 10.1038/Cr.2017.113 |
0.393 |
|
2017 |
Fu Y, Sun X, Lu B. HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease. Autophagy. 1-6. PMID 29130397 DOI: 10.1080/15548627.2017.1393130 |
0.411 |
|
2017 |
Sun X, Fu Y, Pan Y, Lu B. Conformation-dependent Recognition of Mutant HTT (huntingtin) Proteins by Selective Autophagy. Autophagy. 0. PMID 28976800 DOI: 10.1080/15548627.2017.1382783 |
0.381 |
|
2017 |
Fu Y, Wu P, Pan Y, Sun X, Yang H, Difiglia M, Lu B. A toxic mutant huntingtin species is resistant to selective autophagy. Nature Chemical Biology. PMID 28869595 DOI: 10.1038/Nchembio.2461 |
0.354 |
|
2016 |
Vodicka P, Chase K, Iuliano M, Valentine DT, Sapp E, Lu B, Kegel-Gleason KB, Sena-Esteves M, Aronin N, DiFiglia M. Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice. Journal of Huntington's Disease. PMID 27314618 DOI: 10.3233/Jhd-160195 |
0.387 |
|
2016 |
Wu P, Lu MX, Cui XT, Yang HQ, Yu SL, Zhu JB, Sun XL, Lu B. A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins. Acta Pharmacologica Sinica. PMID 27264314 DOI: 10.1038/Aps.2016.31 |
0.394 |
|
2015 |
Yao Y, Cui X, Al-Ramahi I, Sun X, Li B, Hou J, Difiglia M, Palacino J, Wu ZY, Ma L, Botas J, Lu B. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. Elife. 4. PMID 25738228 DOI: 10.7554/Elife.05449 |
0.419 |
|
2014 |
Cui X, Liang Q, Liang Y, Lu M, Ding Y, Lu B. TR-FRET assays of Huntingtin protein fragments reveal temperature and polyQ length-dependent conformational changes. Scientific Reports. 4: 5601. PMID 24998512 DOI: 10.1038/Srep05601 |
0.325 |
|
2014 |
Yu S, Liang Y, Palacino J, Difiglia M, Lu B. Drugging unconventional targets: insights from Huntington's disease. Trends in Pharmacological Sciences. 35: 53-62. PMID 24388390 DOI: 10.1016/J.Tips.2013.12.001 |
0.362 |
|
2013 |
Lu B, Al-Ramahi I, Valencia A, Wang Q, Berenshteyn F, Yang H, Gallego-Flores T, Ichcho S, Lacoste A, Hild M, Difiglia M, Botas J, Palacino J. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Nature Neuroscience. 16: 562-70. PMID 23525043 DOI: 10.1038/Nn.3367 |
0.447 |
|
2013 |
Lu B, Palacino J. A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1820-9. PMID 23325320 DOI: 10.1096/Fj.12-219220 |
0.387 |
|
2010 |
Lu B, Zhang Q, Wang H, Wang Y, Nakayama M, Ren D. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron. 68: 488-99. PMID 21040849 DOI: 10.1016/J.Neuron.2010.09.014 |
0.644 |
|
2009 |
Lu B, Su Y, Das S, Wang H, Wang Y, Liu J, Ren D. Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature. 457: 741-4. PMID 19092807 DOI: 10.1038/Nature07579 |
0.673 |
|
2009 |
Lu B, Su Y, Das S, Wang H, Wang Y, Liu J, Ren D. Regulation of the NALCN Sodium Leak Channel by Neuropeptides Biophysical Journal. 96: 561a. DOI: 10.1016/J.Bpj.2008.12.3682 |
0.667 |
|
2007 |
Lu B, Su Y, Das S, Liu J, Xia J, Ren D. The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell. 129: 371-83. PMID 17448995 DOI: 10.1016/J.Cell.2007.02.041 |
0.652 |
|
2005 |
Lu BX, Liu LY, Liao L, Zhang ZH, Mei YA. Inhibition of Na+ channel currents in rat myoblasts by 4-aminopyridine. Toxicology and Applied Pharmacology. 207: 275-82. PMID 16129120 DOI: 10.1016/J.Taap.2005.01.009 |
0.525 |
|
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