Year |
Citation |
Score |
2019 |
Lee SD, Priest C, Bjursell M, Gao J, Arneson DV, Ahn IS, Diamante G, van Veen JE, Massa MG, Calkin AC, Kim J, Andersén H, Rajbhandari P, Porritt M, Carreras A, ... ... Hong C, et al. IDOL regulates systemic energy balance through control of neuronal VLDLR expression. Nature Metabolism. 1: 1089-1100. PMID 32072135 DOI: 10.1038/s42255-019-0127-7 |
0.634 |
|
2018 |
Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, et al. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Cell. PMID 30220461 DOI: 10.1016/J.Cell.2018.08.033 |
0.567 |
|
2018 |
Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, et al. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Molecular and Cellular Biology. PMID 29507185 DOI: 10.1128/Mcb.00534-17 |
0.634 |
|
2018 |
Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, et al. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nature Medicine. PMID 29431742 DOI: 10.1038/Nm.4479 |
0.686 |
|
2018 |
Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, et al. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 172: 218-233.e17. PMID 29249357 DOI: 10.1016/J.Cell.2017.11.019 |
0.578 |
|
2016 |
Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P. Cholesterol Accumulation in CD11c(+) Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 45: 1311-1326. PMID 28002731 DOI: 10.1016/J.Immuni.2016.11.008 |
0.651 |
|
2016 |
Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, et al. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. PMID 27746144 DOI: 10.1016/J.Ccell.2016.09.008 |
0.574 |
|
2016 |
Sallam T, Jones MC, Gilliland T, Zhang L, Wu X, Eskin A, Sandhu J, Casero D, Vallim TQ, Hong C, Katz M, Lee R, Whitelegge J, Tontonoz P. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature. 534: 124-8. PMID 27251289 DOI: 10.1038/Nature17674 |
0.666 |
|
2016 |
Allan CM, Procaccia S, Tran D, Tu Y, Barnes RH, Larsson M, Allan BB, Young LC, Hong C, Tontonoz P, Fong LG, Young SG, Beigneux AP. Palmoplantar Keratoderma in Slurp2-Deficient Mice. The Journal of Investigative Dermatology. 136: 436-443. PMID 26967477 DOI: 10.1016/J.Jid.2015.11.003 |
0.568 |
|
2015 |
Choi J, Gao J, Kim J, Hong C, Kim J, Tontonoz P. The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis. Science Translational Medicine. 7: 314ra184. PMID 26582899 DOI: 10.1126/Scitranslmed.Aad1904 |
0.573 |
|
2015 |
Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, et al. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. The Journal of Experimental Medicine. PMID 26552708 DOI: 10.1084/Jem.20150603 |
0.632 |
|
2015 |
Tian XY, Ganeshan K, Hong C, Nguyen KD, Qiu Y, Kim J, Tangirala RK, Tonotonoz P, Chawla A. Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance. Cell Metabolism. PMID 26549485 DOI: 10.1016/J.Cmet.2015.10.003 |
0.385 |
|
2015 |
Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife. 4: e08009. PMID 26173179 DOI: 10.7554/Elife.08009 |
0.69 |
|
2015 |
Tontonoz P, Cortez-Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, Conneely O, Metzger D, Chao LC. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Molecular and Cellular Biology. 35: 1125-38. PMID 25605333 DOI: 10.1128/Mcb.00715-14 |
0.558 |
|
2015 |
Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. Author response: LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling Elife. DOI: 10.7554/Elife.08009.023 |
0.593 |
|
2014 |
Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, et al. The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice. Cell Metabolism. 20: 910-8. PMID 25440061 DOI: 10.1016/J.Cmet.2014.10.001 |
0.62 |
|
2014 |
Chung S, Cuffe H, Marshall SM, McDaniel AL, Ha JH, Kavanagh K, Hong C, Tontonoz P, Temel RE, Parks JS. Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1880-7. PMID 24969772 DOI: 10.1161/Atvbaha.114.303896 |
0.58 |
|
2014 |
Calkin AC, Lee SD, Kim J, Van Stijn CM, Wu XH, Lusis AJ, Hong C, Tangirala RI, Tontonoz P. Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice. Circulation Research. 115: 442-9. PMID 24935961 DOI: 10.1161/Circresaha.115.304440 |
0.657 |
|
2014 |
Hong C, Tontonoz P. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nature Reviews. Drug Discovery. 13: 433-44. PMID 24833295 DOI: 10.1038/Nrd4280 |
0.668 |
|
2014 |
Sallam T, Ito A, Rong X, Kim J, van Stijn C, Chamberlain BT, Jung ME, Chao LC, Jones M, Gilliland T, Wu X, Su GL, Tangirala RK, Tontonoz P, Hong C. The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis. Journal of Lipid Research. 55: 1120-1130. PMID 24671012 DOI: 10.1194/Jlr.M047548 |
0.682 |
|
2014 |
Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, et al. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nature Communications. 5: 3147. PMID 24445679 DOI: 10.1038/Ncomms4147 |
0.637 |
|
2013 |
Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metabolism. 18: 685-97. PMID 24206663 DOI: 10.1016/J.Cmet.2013.10.002 |
0.616 |
|
2013 |
A-Gonzalez N, Guillen JA, Gallardo G, Diaz M, de la Rosa JV, Hernandez IH, Casanova-Acebes M, Lopez F, Tabraue C, Beceiro S, Hong C, Lara PC, Andujar M, Arai S, Miyazaki T, et al. The nuclear receptor LXRα controls the functional specialization of splenic macrophages. Nature Immunology. 14: 831-9. PMID 23770640 DOI: 10.1038/Ni.2622 |
0.646 |
|
2013 |
Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, et al. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metabolism. 17: 423-35. PMID 23473036 DOI: 10.1016/J.Cmet.2013.01.016 |
0.616 |
|
2013 |
Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Molecular and Cellular Biology. 33: 1503-14. PMID 23382078 DOI: 10.1128/Mcb.01716-12 |
0.632 |
|
2013 |
Chao LC, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely OM, Tangirala RK, Evans RM, Tontonoz P. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. Journal of Lipid Research. 54: 806-15. PMID 23288947 DOI: 10.1194/Jlr.M034157 |
0.68 |
|
2012 |
Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, et al. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. Journal of Lipid Research. 53: 2610-9. PMID 23028113 DOI: 10.1194/Jlr.M029355 |
0.551 |
|
2012 |
Hong C, Bradley MN, Rong X, Wang X, Wagner A, Grijalva V, Castellani LW, Salazar J, Realegeno S, Boyadjian R, Fogelman AM, Van Lenten BJ, Reddy ST, Lusis AJ, Tangirala RK, et al. LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice Journal of Lipid Research. 53: 1126-1133. PMID 22454476 DOI: 10.1194/Jlr.M022061 |
0.668 |
|
2012 |
Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. The Journal of Clinical Investigation. 122: 337-47. PMID 22156197 DOI: 10.1172/Jci58393 |
0.653 |
|
2011 |
Calkin AC, Goult BT, Zhang L, Fairall L, Hong C, Schwabe JW, Tontonoz P. FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors. Proceedings of the National Academy of Sciences of the United States of America. 108: 20107-12. PMID 22109552 DOI: 10.1073/Pnas.1111589108 |
0.624 |
|
2011 |
Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, Soto H, Zhu S, Babic I, Tanaka K, Dang J, Iwanami A, Gini B, et al. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discovery. 1: 442-56. PMID 22059152 DOI: 10.1158/2159-8290.Cd-11-0102 |
0.603 |
|
2011 |
Zhang L, Fairall L, Goult BT, Calkin AC, Hong C, Millard CJ, Tontonoz P, Schwabe JW. The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes & Development. 25: 1262-74. PMID 21685362 DOI: 10.1101/Gad.2056211 |
0.571 |
|
2011 |
Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Molecular and Cellular Biology. 31: 1885-93. PMID 21343340 DOI: 10.1128/Mcb.01469-10 |
0.675 |
|
2011 |
Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, Salazar JV, Tontonoz P. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. Journal of Lipid Research. 52: 531-9. PMID 21187453 DOI: 10.1194/Jlr.M010686 |
0.805 |
|
2011 |
Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 140: 1052-62. PMID 21134374 DOI: 10.1053/J.Gastro.2010.11.053 |
0.633 |
|
2010 |
Feig JE, Pineda-Torra I, Sanson M, Bradley MN, Vengrenyuk Y, Bogunovic D, Gautier EL, Rubinstein D, Hong C, Liu J, Wu C, van Rooijen N, Bhardwaj N, Garabedian M, Tontonoz P, et al. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. The Journal of Clinical Investigation. 120: 4415-24. PMID 21041949 DOI: 10.1172/Jci38911 |
0.609 |
|
2010 |
Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, Boyadjian R, Rodenburg KW, Foley E, Korhonen L, Lindholm D, Nimpf J, van Berkel TJ, Tontonoz P, Zelcer N. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. The Journal of Biological Chemistry. 285: 19720-6. PMID 20427281 DOI: 10.1074/Jbc.M110.123729 |
0.684 |
|
2009 |
A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, DÃaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 31: 245-58. PMID 19646905 DOI: 10.1016/J.Immuni.2009.06.018 |
0.648 |
|
2009 |
Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F. Negative regulation of Hedgehog signaling by liver X receptors. Molecular Endocrinology (Baltimore, Md.). 23: 1532-43. PMID 19608643 DOI: 10.1210/Me.2008-0453 |
0.652 |
|
2009 |
Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science (New York, N.Y.). 325: 100-4. PMID 19520913 DOI: 10.1126/Science.1168974 |
0.665 |
|
2009 |
Marathe C, Bradley MN, Hong C, Chao L, Wilpitz D, Salazar J, Tontonoz P. Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow. Journal of Lipid Research. 50: 214-24. PMID 18772483 DOI: 10.1194/Jlr.M800189-Jlr200 |
0.782 |
|
2008 |
Hong C, Tontonoz P. Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors. Current Opinion in Genetics & Development. 18: 461-7. PMID 18782619 DOI: 10.1016/J.Gde.2008.07.016 |
0.691 |
|
2008 |
Hummasti S, Hong C, Bensinger SJ, Tontonoz P. HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation. Journal of Lipid Research. 49: 2535-44. PMID 18664718 DOI: 10.1194/Jlr.M800269-Jlr200 |
0.783 |
|
2008 |
Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P. Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. Molecular Endocrinology (Baltimore, Md.). 22: 2038-48. PMID 18562627 DOI: 10.1210/Me.2007-0454 |
0.649 |
|
2007 |
Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. The Journal of Clinical Investigation. 117: 2337-46. PMID 17657314 DOI: 10.1172/Jci31909 |
0.76 |
|
2006 |
Marathe C, Bradley MN, Hong C, Lopez F, Ruiz de Galarreta CM, Tontonoz P, Castrillo A. The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages. The Journal of Biological Chemistry. 281: 32197-206. PMID 16943198 DOI: 10.1074/Jbc.M605237200 |
0.789 |
|
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