| Year |
Citation |
Score |
| 2022 |
Dennison JL, Al-Ali H, Volmar CH, Brothers S, Watts J, Wahlestedt C, Lohse I. Functional Drug Screening of Small Molecule Inhibitors of Epigenetic Modifiers in Refractory AML Patients. Cancers. 14. PMID 36077629 DOI: 10.3390/cancers14174094 |
0.471 |
|
| 2022 |
Kemper C, Benham D, Brothers S, Wahlestedt C, Volmar CH, Bennett D, Hayward M. Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL ). Aaps Open. 8: 11. PMID 35789594 DOI: 10.1186/s41120-022-00058-1 |
0.42 |
|
| 2022 |
Dennison JL, Volmar CH, Modarresi F, Ke D, Wang J, Gravel E, Hammond-Vignini S, Li Z, Timmons JA, Lohse I, Hayward MA, Brothers SP, Wahlestedt C. Erratum to: JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model. Journal of Alzheimer's Disease : Jad. PMID 35723129 DOI: 10.3233/JAD-229006 |
0.406 |
|
| 2022 |
Dennison JL, Volmar CH, Ke D, Wang J, Gravel E, Hammond-Vignini S, Li Z, Timmons JA, Lohse I, Hayward MA, Brothers SP, Wahlestedt C. JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model. Journal of Alzheimer's Disease : Jad. PMID 35034905 DOI: 10.3233/JAD-215370 |
0.432 |
|
| 2022 |
Khalafi S, Zhu S, Khurana R, Lohse I, Giordano S, Corso S, Al-Ali H, Brothers SP, Wahlestedt C, Schürer S, El-Rifai W. A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer. Translational Oncology. 15: 101260. PMID 34735897 DOI: 10.1016/j.tranon.2021.101260 |
0.46 |
|
| 2020 |
Kuznetsoff JN, Owens DA, Lopez A, Rodriguez DA, Chee NT, Kurtenbach S, Bilbao D, Roberts ER, Volmar CH, Wahlestedt C, Brothers SP, Harbour JW. Dual screen for efficacy and toxicity identifies HDAC inhibitor with distinctive activity spectrum for BAP1-mutant uveal melanoma. Molecular Cancer Research : McR. PMID 33077485 DOI: 10.1158/1541-7786.MCR-20-0434 |
0.464 |
|
| 2019 |
Lohse I, Azzam DJ, Al-Ali H, Volmar CH, Brothers SP, Ince TA, Wahlestedt C. Ovarian Cancer Treatment Stratification Using Drug Sensitivity Testing. Anticancer Research. 39: 4023-4030. PMID 31366484 DOI: 10.21873/Anticanres.13558 |
0.426 |
|
| 2019 |
Mustafi S, Camarena V, Qureshi R, Yoon H, Volmar CH, Huff TC, Sant DW, Zheng L, Brothers SP, Wahlestedt C, Slingerland J, Wang G. Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer. Ebiomedicine. PMID 30975544 DOI: 10.1016/J.Ebiom.2019.04.006 |
0.407 |
|
| 2019 |
Bagheri A, Habibzadeh P, Razavipour SF, Volmar CH, Chee NT, Brothers SP, Wahlestedt C, Mowla SJ, Faghihi MA. HDAC Inhibitors Induce Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons. International Journal of Molecular Sciences. 20. PMID 30841499 DOI: 10.3390/ijms20051109 |
0.454 |
|
| 2018 |
Copsel SN, Lightbourn CO, Barreras H, Lohse I, Wolf D, Bader CS, Manov J, Kale BJ, Shah D, Brothers SP, Perez VL, Komanduri KV, Wahlestedt C, Levy RB. BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT. Frontiers in Immunology. 9: 3104. PMID 30733722 DOI: 10.3389/fimmu.2018.03104 |
0.45 |
|
| 2018 |
Lohse I, Statz-Geary K, Brothers SP, Wahlestedt C. Precision medicine in the treatment stratification of AML patients: challenges and progress. Oncotarget. 9: 37790-37797. PMID 30701032 DOI: 10.18632/oncotarget.26492 |
0.433 |
|
| 2018 |
Janczura KJ, Volmar CH, Sartor GC, Rao SJ, Ricciardi NR, Lambert G, Brothers SP, Wahlestedt C. Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model. Proceedings of the National Academy of Sciences of the United States of America. PMID 30397132 DOI: 10.1073/Pnas.1805436115 |
0.442 |
|
| 2018 |
Lohse I, Al-Ali H, Volmar CH, D Alvarez Trotta A, Brothers SP, Capobianco AJ, Wahlestedt C. Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma. Plos One. 13: e0203173. PMID 30212533 DOI: 10.1371/Journal.Pone.0203173 |
0.428 |
|
| 2018 |
Johnstone AL, O'Reilly JJ, Patel AJ, Guo Z, Andrade NS, Magistri M, Nathanson L, Esanov R, Miller BH, Turecki G, Brothers SP, Zeier Z, Wahlestedt C. Enhancer of Zeste 1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia. Neurobiology of Disease. PMID 30099093 DOI: 10.1016/J.Nbd.2018.08.005 |
0.401 |
|
| 2017 |
Mustafi S, Camarena V, Volmar CH, Huff TC, Sant DW, Brothers SP, Liu ZJ, Wahlestedt C, Wang G. Vitamin C sensitizes melanoma to BET inhibitors. Cancer Research. PMID 29180474 DOI: 10.1158/0008-5472.Can-17-2040 |
0.475 |
|
| 2017 |
Swords RT, Azzam D, Al-Ali H, Lohse I, Volmar CH, Watts JM, Perez A, Rodriguez A, Vargas F, Elias R, Vega F, Zelent A, Brothers SP, Abbasi T, Trent J, et al. Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study. Leukemia Research. 64: 34-41. PMID 29175379 DOI: 10.1016/J.Leukres.2017.11.008 |
0.438 |
|
| 2017 |
Volmar CH, Salah-Uddin H, Janczura KJ, Halley P, Lambert G, Wodrich A, Manoah S, Patel NH, Sartor GC, Mehta N, Miles NTH, Desse S, Dorcius D, Cameron MD, Brothers SP, et al. M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory. Proceedings of the National Academy of Sciences of the United States of America. 114: E9135-E9144. PMID 29073110 DOI: 10.1073/Pnas.1707544114 |
0.452 |
|
| 2017 |
Jones C, Barrera I, Brothers S, Ring R, Wahlestedt C. Oxytocin and social functioning. Dialogues in Clinical Neuroscience. 19: 193-201. PMID 28867943 |
0.397 |
|
| 2016 |
Aziz AM, Brothers S, Sartor G, Holm L, Heilig M, Wahlestedt C, Thorsell A. The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models. Psychopharmacology. PMID 27515665 DOI: 10.1016/J.Alcohol.2017.02.313 |
0.404 |
|
| 2016 |
Volmar CH, Wahlestedt C, Brothers SP. Orphan diseases: state of the drug discovery art. Wiener Medizinische Wochenschrift (1946). PMID 26819216 DOI: 10.1007/s10354-015-0423-0 |
0.426 |
|
| 2015 |
Sartor GC, Powell SK, Wiedner HJ, Wahlestedt C, Brothers SP. "Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice". Brain Research. PMID 26657743 DOI: 10.1016/J.Brainres.2015.11.044 |
0.425 |
|
| 2015 |
Sartor GC, Powell SK, Brothers SP, Wahlestedt C. Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15062-72. PMID 26558777 DOI: 10.1523/Jneurosci.0826-15.2015 |
0.427 |
|
| 2015 |
Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, et al. Bromodomain inhibitors regulate the C9ORF72 locus in ALS. Experimental Neurology. 271: 241-50. PMID 26099177 DOI: 10.1016/J.Expneurol.2015.06.017 |
0.491 |
|
| 2015 |
Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, et al. Bromodomain inhibitors regulate the C9ORF72 locus in ALS Experimental Neurology. 271: 241-250. DOI: 10.1016/j.expneurol.2015.06.017 |
0.402 |
|
| 2014 |
Carlsson SK, Brothers SP, Wahlestedt C. Emerging treatment strategies for glioblastoma multiforme. Embo Molecular Medicine. 6: 1359-70. PMID 25312641 DOI: 10.15252/Emmm.201302627 |
0.417 |
|
| 2014 |
Barrett E, Brothers S, Wahlestedt C, Beurel E. I-BET151 selectively regulates IL-6 production. Biochimica Et Biophysica Acta. 1842: 1549-55. PMID 24859008 DOI: 10.1016/J.Bbadis.2014.05.013 |
0.43 |
|
| 2014 |
Pastori C, Daniel M, Penas C, Volmar CH, Johnstone AL, Brothers SP, Graham RM, Allen B, Sarkaria JN, Komotar RJ, Wahlestedt C, Ayad NG. BET bromodomain proteins are required for glioblastoma cell proliferation. Epigenetics : Official Journal of the Dna Methylation Society. 9: 611-20. PMID 24496381 DOI: 10.4161/Epi.27906 |
0.48 |
|
| 2013 |
Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ. Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD. Science Translational Medicine. 5: 188ra73. PMID 23740899 DOI: 10.1126/Scitranslmed.3005656 |
0.426 |
|
| 2012 |
Mittapalli GK, Vellucci D, Yang J, Toussaint M, Brothers SP, Wahlestedt C, Roberts E. Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 22: 3916-20. PMID 22607676 DOI: 10.1016/J.Bmcl.2012.04.107 |
0.451 |
|
| 2012 |
Modarresi F, Faghihi MA, Lopez-Toledano MA, Fatemi RP, Magistri M, Brothers SP, van der Brug MP, Wahlestedt C. Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nature Biotechnology. 30: 453-9. PMID 22446693 DOI: 10.1038/Nbt.2158 |
0.459 |
|
| 2010 |
Brothers SP, Wahlestedt C. Therapeutic potential of neuropeptide Y (NPY) receptor ligands. Embo Molecular Medicine. 2: 429-39. PMID 20972986 DOI: 10.1002/Emmm.201000100 |
0.494 |
|
| 2010 |
Faghihi MA, Kocerha J, Modarresi F, Engström PG, Chalk AM, Brothers SP, Koesema E, St Laurent G, Wahlestedt C. RNAi screen indicates widespread biological function for human natural antisense transcripts. Plos One. 5. PMID 20957177 DOI: 10.1371/Journal.Pone.0013177 |
0.437 |
|
| 2010 |
Brothers SP, Saldanha SA, Spicer TP, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Molecular Pharmacology. 77: 46-57. PMID 19837904 DOI: 10.1124/Mol.109.058677 |
0.482 |
|
| 2008 |
Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C. A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. Plos One. 3: e1486. PMID 18213394 DOI: 10.1371/Journal.Pone.0001486 |
0.437 |
|
| 2007 |
Janovick JA, Brothers SP, Cornea A, Bush E, Goulet MT, Ashton WT, Sauer DR, Haviv F, Greer J, Conn PM. Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitro. Molecular and Cellular Endocrinology. 272: 77-85. PMID 17555869 DOI: 10.1016/j.mce.2007.04.012 |
0.496 |
|
| 2007 |
Janovick JA, Brothers SP, Knollman PE, Conn PM. Specializations of a G-protein-coupled receptor that appear to aid with detection of frequency-modulated signals from its ligand. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 384-92. PMID 17172315 DOI: 10.1096/fj.06-6901com |
0.5 |
|
| 2006 |
Brothers SP, Janovick JA, Conn PM. Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression. Journal of Molecular Endocrinology. 37: 479-88. PMID 17170088 DOI: 10.1677/jme.1.02142 |
0.511 |
|
| 2006 |
Conn PM, Janovick JA, Brothers SP, Knollman PE. 'Effective inefficiency': cellular control of protein trafficking as a mechanism of post-translational regulation. The Journal of Endocrinology. 190: 13-6. PMID 16837606 DOI: 10.1677/joe.1.06771 |
0.502 |
|
| 2006 |
Conn PM, Knollman PE, Brothers SP, Janovick JA. Protein folding as posttranslational regulation: evolution of a mechanism for controlled plasma membrane expression of a G protein-coupled receptor. Molecular Endocrinology (Baltimore, Md.). 20: 3035-41. PMID 16556733 DOI: 10.1210/me.2006-0066 |
0.528 |
|
| 2006 |
Janovick JA, Knollman PE, Brothers SP, Ayala-Yáñez R, Aziz AS, Conn PM. Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy. The Journal of Biological Chemistry. 281: 8417-25. PMID 16446355 DOI: 10.1074/jbc.M510601200 |
0.532 |
|
| 2005 |
Knollman PE, Janovick JA, Brothers SP, Conn PM. Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants. The Journal of Biological Chemistry. 280: 24506-14. PMID 15886197 DOI: 10.1074/jbc.M501978200 |
0.509 |
|
| 2004 |
Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM. Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease. Traffic (Copenhagen, Denmark). 5: 821-37. PMID 15479448 DOI: 10.1111/j.1600-0854.2004.00232.x |
0.483 |
|
| 2004 |
Brothers SP, Cornea A, Janovick JA, Conn PM. Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect. Molecular Endocrinology (Baltimore, Md.). 18: 1787-97. PMID 15105440 DOI: 10.1210/me.2004-0091 |
0.533 |
|
| 2003 |
Brothers SP, Janovick JA, Conn PM. Unexpected effects of epitope and chimeric tags on gonadotropin-releasing hormone receptors: implications for understanding the molecular etiology of hypogonadotropic hypogonadism. The Journal of Clinical Endocrinology and Metabolism. 88: 6107-12. PMID 14671217 DOI: 10.1210/Jc.2003-031047 |
0.5 |
|
| 2003 |
Castro-Fernández C, Brothers SP, Conn PM. A Gαs mutation (D229S) differentially effects gonadotropin-releasing hormone receptor regulation by RGS10, RGS3 and RGS3T Molecular and Cellular Endocrinology. 200: 119-126. DOI: 10.1016/S0303-7207(02)00378-7 |
0.456 |
|
| 2002 |
Brothers SP, Janovick JA, Maya-Nunez G, Cornea A, Han XB, Conn PM. Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization. Molecular and Cellular Endocrinology. 190: 19-27. PMID 11997175 DOI: 10.1016/S0303-7207(02)00040-0 |
0.486 |
|
| 2002 |
Castro-Fernández C, Janovick JA, Brothers SP, Fisher RA, Ji TH, Conn PM. Regulation of RGS3 and RGS10 palmitoylation by GnRH. Endocrinology. 143: 1310-7. PMID 11897687 DOI: 10.1210/Endo.143.4.8713 |
0.479 |
|
| 1999 |
Lin X, Janovick JA, Brothers S, Conn PM, Peter RE. Molecular cloning and expression of two type one somatostatin receptors in goldfish brain. Endocrinology. 140: 5211-9. PMID 10537151 DOI: 10.1210/endo.140.11.7094 |
0.491 |
|
| 1998 |
Ulloa-Aguirre A, Stanislaus D, Arora V, Väänänen J, Brothers S, Janovick JA, Conn PM. The third intracellular loop of the rat gonadotropin-releasing hormone receptor couples the receptor to Gs- and G(q/11)-mediated signal transduction pathways: evidence from loop fragment transfection in GGH3 cells. Endocrinology. 139: 2472-8. PMID 9564860 DOI: 10.1210/endo.139.5.6022 |
0.502 |
|
| 1998 |
Lin X, Janovick JA, Brothers S, Blömenrohr M, Bogerd J, Conn PM. Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation. Molecular Endocrinology (Baltimore, Md.). 12: 161-71. PMID 9482659 DOI: 10.1210/mend.12.2.0056 |
0.505 |
|
| 1997 |
Stanislaus D, Janovick JA, Brothers S, Conn PM. Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor. Molecular Endocrinology (Baltimore, Md.). 11: 738-46. PMID 9171237 DOI: 10.1210/mend.11.6.0005 |
0.449 |
|
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