| Year |
Citation |
Score |
| 2018 |
Tao YX, Conn PM. Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases. Physiological Reviews. 98: 697-725. PMID 29442594 DOI: 10.1152/physrev.00029.2016 |
0.317 |
|
| 2017 |
Janovick JA, Spicer TP, Bannister TD, Scampavia L, Conn PM. Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias. Plos One. 12: e0181830. PMID 28767678 DOI: 10.1371/Journal.Pone.0181830 |
0.525 |
|
| 2016 |
Janovick JA, Spicer TP, Smith E, Bannister TD, Kenakin T, Scampavia L, Conn PM. Receptor antagonism/agonism can be uncoupled from pharmacoperone activity. Molecular and Cellular Endocrinology. PMID 27389877 DOI: 10.1016/J.Mce.2016.07.003 |
0.35 |
|
| 2016 |
Ulloa-Aguirre A, Conn PM. Pharmacoperones as a New Therapeutic Approach: In vitro Identification and In vivo Validation of Bioactive Molecules. Current Drug Targets. PMID 26953247 |
0.447 |
|
| 2015 |
Conn PM, Spicer TP, Scampavia L, Janovick JA. Assay strategies for identification of therapeutic leads that target protein trafficking. Trends in Pharmacological Sciences. 36: 498-505. PMID 26067100 DOI: 10.1016/j.tips.2015.05.004 |
0.324 |
|
| 2014 |
Conn PM, Smith E, Spicer T, Chase P, Scampavia L, Janovick JA. A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor. Assay and Drug Development Technologies. 12: 238-46. PMID 24831790 DOI: 10.1089/Adt.2014.576 |
0.43 |
|
| 2014 |
Houck SA, Ren HY, Madden VJ, Bonner JN, Conlin MP, Janovick JA, Conn PM, Cyr DM. Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR. Molecular Cell. 54: 166-79. PMID 24685158 DOI: 10.1016/j.molcel.2014.02.025 |
0.34 |
|
| 2014 |
Tao YX, Conn PM. Chaperoning G protein-coupled receptors: from cell biology to therapeutics. Endocrine Reviews. 35: 602-47. PMID 24661201 DOI: 10.1210/er.2013-1121 |
0.493 |
|
| 2014 |
Ulloa-Aguirre A, Zariñán T, Dias JA, Conn PM. Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function. Molecular and Cellular Endocrinology. 382: 411-23. PMID 23806559 DOI: 10.1016/J.Mce.2013.06.024 |
0.594 |
|
| 2014 |
Ulloa-Aguirre A, Conn PM. Intracellular Trafficking of G Protein-Coupled Receptors to the Plasma Membrane in Health and Disease Cellular Endocrinology in Health and Disease. 341-364. DOI: 10.1016/B978-0-12-408134-5.00021-4 |
0.408 |
|
| 2013 |
Janovick JA, Stewart MD, Jacob D, Martin LD, Deng JM, Stewart CA, Wang Y, Cornea A, Chavali L, Lopez S, Mitalipov S, Kang E, Lee HS, Manna PR, Stocco DM, ... ... Conn PM, et al. Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy. Proceedings of the National Academy of Sciences of the United States of America. 110: 21030-5. PMID 24324164 DOI: 10.1073/Pnas.1315194110 |
0.43 |
|
| 2013 |
Conn PM. Methods in Cell Biology. Receptor-receptor interactions. Preface. Methods in Cell Biology. 117: xxi-xxii. PMID 24143993 DOI: 10.1016/B978-0-12-408143-7.10000-3 |
0.396 |
|
| 2013 |
Cabrera-Wrooman A, Janovick JA, Conn PM. Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system. Molecular and Cellular Endocrinology. 381: 1-7. PMID 23891857 DOI: 10.1016/J.Mce.2013.07.012 |
0.388 |
|
| 2013 |
Conn PM, Smith E, Hodder P, Janovick JA, Smithson DC. High-throughput screen for pharmacoperones of the vasopressin type 2 receptor. Journal of Biomolecular Screening. 18: 930-7. PMID 23640875 DOI: 10.1177/1087057113483559 |
0.335 |
|
| 2013 |
Conn PM. Methods in Enzymology. G protein coupled receptors trafficking and oligomerization. Preface. Methods in Enzymology. 521: xix. PMID 23351751 DOI: 10.1016/B978-0-12-391862-8.10000-6 |
0.423 |
|
| 2013 |
Smithson DC, Janovick JA, Conn PM. Therapeutic rescue of misfolded/mistrafficked mutants: automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs. Methods in Enzymology. 521: 3-16. PMID 23351731 DOI: 10.1016/B978-0-12-391862-8.00001-6 |
0.44 |
|
| 2012 |
Aguilar-Rojas A, Huerta-Reyes M, Maya-Núñez G, Arechavaleta-Velásco F, Conn PM, Ulloa-Aguirre A, Valdés J. Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231. Bmc Cancer. 12: 550. PMID 23176180 DOI: 10.1186/1471-2407-12-550 |
0.372 |
|
| 2012 |
Maya-Núñez G, Ulloa-Aguirre A, Janovick JA, Conn PM. Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target. Sub-Cellular Biochemistry. 63: 263-89. PMID 23161143 DOI: 10.1007/978-94-007-4765-4_14 |
0.48 |
|
| 2012 |
Stewart MD, Deng JM, Stewart CA, Mullen RD, Wang Y, Lopez S, Serna MK, Huang CC, Janovick JA, Pask AJ, Schwartz RJ, Conn PM, Behringer RR. Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failure. Molecular Endocrinology (Baltimore, Md.). 26: 1847-56. PMID 22918878 DOI: 10.1210/Me.2012-1072 |
0.47 |
|
| 2012 |
Janovick JA, Pogozheva ID, Mosberg HI, Cornea A, Conn PM. Rescue of misrouted GnRHR mutants reveals its constitutive activity. Molecular Endocrinology (Baltimore, Md.). 26: 1179-88. PMID 22595961 DOI: 10.1210/Me.2012-1089 |
0.343 |
|
| 2011 |
Ulloa-Aguirre A, Conn PM. Pharmacoperones: A new therapeutic approach for diseases caused by misfolded G protein-coupled receptors Recent Patents On Endocrine, Metabolic and Immune Drug Discovery. 5: 13-24. PMID 22074574 DOI: 10.2174/187221411794351851 |
0.445 |
|
| 2011 |
Conn PM, Ulloa-Aguirre A. Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors. Advances in Pharmacology (San Diego, Calif.). 62: 109-41. PMID 21907908 DOI: 10.1016/B978-0-12-385952-5.00008-7 |
0.637 |
|
| 2011 |
Janovick JA, Park BS, Conn PM. Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. Plos One. 6: e22784. PMID 21818389 DOI: 10.1371/journal.pone.0022784 |
0.422 |
|
| 2011 |
Conn PM, Janovick JA. Pharmacoperone identification for therapeutic rescue of misfolded mutant proteins. Frontiers in Endocrinology. 2. PMID 21633718 DOI: 10.3389/fendo.2011.00006 |
0.313 |
|
| 2011 |
Janovick JA, Pogozheva ID, Mosberg HI, Conn PM. Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation. The Journal of Pharmacology and Experimental Therapeutics. 338: 430-42. PMID 21527534 DOI: 10.1124/Jpet.111.180869 |
0.518 |
|
| 2011 |
Maya-Núñez G, Janovick JA, Aguilar-Rojas A, Jardón-Valadez E, Leaños-Miranda A, Zariñan T, Ulloa-Aguirre A, Conn PM. Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism. Molecular and Cellular Endocrinology. 337: 16-23. PMID 21277937 DOI: 10.1016/j.mce.2011.01.016 |
0.426 |
|
| 2010 |
Janovick JA, Conn PM. Use of pharmacoperones to reveal GPCR structural changes associated with constitutive activation and trafficking. Methods in Enzymology. 485: 277-92. PMID 21050923 DOI: 10.1016/B978-0-12-381296-4.00016-6 |
0.529 |
|
| 2010 |
Re M, Pampillo M, Savard M, Dubuc C, McArdle CA, Millar RP, Conn PM, Gobeil F, Bhattacharya M, Babwah AV. The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane. Plos One. 5: e11489. PMID 20628612 DOI: 10.1371/Journal.Pone.0011489 |
0.62 |
|
| 2010 |
Zariñán T, Perez-SolÃs MA, Maya-Núñez G, Casas-González P, Conn PM, Dias JA, Ulloa-Aguirre A. Dominant negative effects of human follicle-stimulating hormone receptor expression-deficient mutants on wild-type receptor cell surface expression. Rescue of oligomerization-dependent defective receptor expression by using cognate decoys. Molecular and Cellular Endocrinology. 321: 112-22. PMID 20206665 DOI: 10.1016/J.Mce.2010.02.027 |
0.51 |
|
| 2010 |
Janovick JA, Conn PM. Salt bridge integrates GPCR activation with protein trafficking. Proceedings of the National Academy of Sciences of the United States of America. 107: 4454-8. PMID 20160100 DOI: 10.1073/pnas.0914261107 |
0.502 |
|
| 2010 |
Ayala Yáñez R, Conn PM. Protein disulfide isomerase chaperone ERP-57 decreases plasma membrane expression of the human GnRH receptor. Cell Biochemistry and Function. 28: 66-73. PMID 20029959 DOI: 10.1002/cbf.1622 |
0.525 |
|
| 2010 |
Conn PM, Ulloa-Aguirre A. Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs. Trends in Endocrinology and Metabolism: Tem. 21: 190-7. PMID 20005736 DOI: 10.1016/j.tem.2009.11.003 |
0.517 |
|
| 2010 |
Jennes L, Ulloa-Aguirre A, Janovick JA, Adjan VV, Conn PM. The gonadotropin-releasing hormone and its receptor Hormones, Brain and Behavior Online. 1645-1669. DOI: 10.1016/B978-008088783-8.00051-6 |
0.431 |
|
| 2009 |
Conn PM, Janovick JA. Drug development and the cellular quality control system. Trends in Pharmacological Sciences. 30: 228-33. PMID 19307028 DOI: 10.1016/J.Tips.2009.02.002 |
0.545 |
|
| 2009 |
Lucca-Junior W, Janovick JA, Conn PM. Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Mã©Dicas E Biolã³Gicas / Sociedade Brasileira De BiofãSica ... [Et Al.]. 42: 164-7. PMID 19274343 |
0.415 |
|
| 2009 |
Ulloa-Aguirre A, Conn PM. Targeting of G protein-coupled receptors to the plasma membrane in health and disease. Frontiers in Bioscience (Landmark Edition). 14: 973-94. PMID 19273112 DOI: 10.2741/3290 |
0.475 |
|
| 2009 |
Jardón-Valadez E, Aguilar-Rojas A, Maya-Núñez G, Leaños-Miranda A, Piñeiro A, Conn PM, Ulloa-Aguirre A. Conformational effects of Lys191 in the human GnRH receptor: mutagenesis and molecular dynamics simulations studies. The Journal of Endocrinology. 201: 297-307. PMID 19246515 DOI: 10.1677/JOE-08-0527 |
0.374 |
|
| 2009 |
Janovick JA, Patny A, Mosley R, Goulet MT, Altman MD, Rush TS, Cornea A, Conn PM. Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor. Molecular Endocrinology (Baltimore, Md.). 23: 157-68. PMID 19095769 DOI: 10.1210/Me.2008-0384 |
0.583 |
|
| 2009 |
Conn PM, Janovick JA. Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease. Molecular and Cellular Endocrinology. 299: 137-45. PMID 19059461 DOI: 10.1016/J.Mce.2008.10.051 |
0.567 |
|
| 2009 |
Janovick JA, Maya-Núñez G, Ulloa-Aguirre A, Huhtaniemi IT, Dias JA, Verbost P, Conn PM. Increased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine. Molecular and Cellular Endocrinology. 298: 84-8. PMID 18848862 DOI: 10.1016/J.Mce.2008.09.015 |
0.467 |
|
| 2008 |
Knollman PE, Conn PM. Multiple G proteins compete for binding with the human gonadotropin releasing hormone receptor. Archives of Biochemistry and Biophysics. 477: 92-7. PMID 18541137 DOI: 10.1016/j.abb.2008.05.011 |
0.311 |
|
| 2007 |
Conn PM, Ulloa-Aguirre A, Ito J, Janovick JA. G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo. Pharmacological Reviews. 59: 225-50. PMID 17878512 DOI: 10.1124/pr.59.3.2 |
0.558 |
|
| 2007 |
Janovick JA, Brothers SP, Cornea A, Bush E, Goulet MT, Ashton WT, Sauer DR, Haviv F, Greer J, Conn PM. Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitro. Molecular and Cellular Endocrinology. 272: 77-85. PMID 17555869 DOI: 10.1016/j.mce.2007.04.012 |
0.716 |
|
| 2007 |
Janovick JA, Brothers SP, Knollman PE, Conn PM. Specializations of a G-protein-coupled receptor that appear to aid with detection of frequency-modulated signals from its ligand. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 384-92. PMID 17172315 DOI: 10.1096/fj.06-6901com |
0.741 |
|
| 2007 |
Ulloa-Aguirre A, Zariñán T, Uribe A, Maya-Núñez G, Conn PM, Pérez-Solis M. DOMINANT NEGATIVE ACTION OF FOLLICLE-STIMULATING HORMONE RECEPTOR (FSHR) MUTANTS ON WILDTYPE FSHR CELL SURFACE MEMBRANE EXPRESSION Biology of Reproduction. 77: 106-107. DOI: 10.1093/BIOLREPROD/77.S1.106D |
0.407 |
|
| 2006 |
Brothers SP, Janovick JA, Conn PM. Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression. Journal of Molecular Endocrinology. 37: 479-88. PMID 17170088 DOI: 10.1677/jme.1.02142 |
0.76 |
|
| 2006 |
Ulloa-Aguirre A, Janovick JA, Miranda AL, Conn PM. G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease. Acs Chemical Biology. 1: 631-8. PMID 17168568 DOI: 10.1021/cb600360h |
0.567 |
|
| 2006 |
Conn PM, Janovick JA, Brothers SP, Knollman PE. 'Effective inefficiency': cellular control of protein trafficking as a mechanism of post-translational regulation. The Journal of Endocrinology. 190: 13-6. PMID 16837606 DOI: 10.1677/joe.1.06771 |
0.72 |
|
| 2006 |
Conn PM, Knollman PE, Brothers SP, Janovick JA. Protein folding as posttranslational regulation: evolution of a mechanism for controlled plasma membrane expression of a G protein-coupled receptor. Molecular Endocrinology (Baltimore, Md.). 20: 3035-41. PMID 16556733 DOI: 10.1210/me.2006-0066 |
0.766 |
|
| 2006 |
Janovick JA, Knollman PE, Brothers SP, Ayala-Yáñez R, Aziz AS, Conn PM. Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy. The Journal of Biological Chemistry. 281: 8417-25. PMID 16446355 DOI: 10.1074/jbc.M510601200 |
0.781 |
|
| 2005 |
Knollman PE, Janovick JA, Brothers SP, Conn PM. Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants. The Journal of Biological Chemistry. 280: 24506-14. PMID 15886197 DOI: 10.1074/jbc.M501978200 |
0.754 |
|
| 2005 |
Leaños-Miranda A, Ulloa-Aguirre A, Janovick JA, Conn PM. In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles. The Journal of Clinical Endocrinology and Metabolism. 90: 3001-8. PMID 15728205 DOI: 10.1210/jc.2004-2071 |
0.435 |
|
| 2005 |
Pask AJ, Kanasaki H, Kaiser UB, Conn PM, Janovick JA, Stockton DW, Hess DL, Justice MJ, Behringer RR. A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Molecular Endocrinology (Baltimore, Md.). 19: 972-81. PMID 15625238 DOI: 10.1210/Me.2004-0192 |
0.462 |
|
| 2005 |
Castro-Fernández C, Maya-Núñez G, Conn PM. Beyond the signal sequence: protein routing in health and disease. Endocrine Reviews. 26: 479-503. PMID 15536207 DOI: 10.1210/er.2004-0010 |
0.313 |
|
| 2004 |
Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM. Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease. Traffic (Copenhagen, Denmark). 5: 821-37. PMID 15479448 DOI: 10.1111/j.1600-0854.2004.00232.x |
0.686 |
|
| 2004 |
Washington TM, Blum JJ, Reed MC, Conn PM. A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH. Theoretical Biology & Medical Modelling. 1: 9. PMID 15447787 DOI: 10.1186/1742-4682-1-9 |
0.513 |
|
| 2004 |
Timossi C, Ortiz-Elizondo C, Pineda DB, Dias JA, Conn PM, Ulloa-Aguirre A. Functional significance of the BBXXB motif reversed present in the cytoplasmic domains of the human follicle-stimulating hormone receptor. Molecular and Cellular Endocrinology. 223: 17-26. PMID 15279907 DOI: 10.1016/J.Mce.2004.06.004 |
0.464 |
|
| 2004 |
Meysing AU, Kanasaki H, Bedecarrats GY, Acierno JS, Conn PM, Martin KA, Seminara SB, Hall JE, Crowley WF, Kaiser UB. GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone. The Journal of Clinical Endocrinology and Metabolism. 89: 3189-98. PMID 15240592 DOI: 10.1210/Jc.2003-031808 |
0.506 |
|
| 2004 |
Brothers SP, Cornea A, Janovick JA, Conn PM. Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect. Molecular Endocrinology (Baltimore, Md.). 18: 1787-97. PMID 15105440 DOI: 10.1210/me.2004-0091 |
0.773 |
|
| 2004 |
Ulloa-Aguirre A, Janovick JA, Leaños-Miranda A, Conn PM. Misrouted cell surface GnRH receptors as a disease aetiology for congenital isolated hypogonadotrophic hypogonadism. Human Reproduction Update. 10: 177-92. PMID 15073146 DOI: 10.1093/humupd/dmh015 |
0.597 |
|
| 2003 |
Janovick JA, Ulloa-Aguirre A, Conn PM. Evolved regulation of gonadotropin-releasing hormone receptor cell surface expression. Endocrine. 22: 317-27. PMID 14709805 DOI: 10.1385/ENDO:22:3:317 |
0.459 |
|
| 2003 |
Brothers SP, Janovick JA, Conn PM. Unexpected effects of epitope and chimeric tags on gonadotropin-releasing hormone receptors: implications for understanding the molecular etiology of hypogonadotropic hypogonadism. The Journal of Clinical Endocrinology and Metabolism. 88: 6107-12. PMID 14671217 DOI: 10.1210/Jc.2003-031047 |
0.749 |
|
| 2003 |
Kumar TR, Agno J, Janovick JA, Conn PM, Matzuk MM. Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice. Molecular and Cellular Endocrinology. 212: 19-27. PMID 14654247 DOI: 10.1016/J.Mce.2003.09.019 |
0.45 |
|
| 2003 |
Leaños-Miranda A, Ulloa-Aguirre A, Ji TH, Janovick JA, Conn PM. Dominant-negative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans. The Journal of Clinical Endocrinology and Metabolism. 88: 3360-7. PMID 12843188 DOI: 10.1210/jc.2003-030084 |
0.546 |
|
| 2003 |
Ulloa-Aguirre A, Janovick JA, Leaños-Miranda A, Conn PM. Misrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: the case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance. Expert Opinion On Therapeutic Targets. 7: 175-85. PMID 12667096 DOI: 10.1517/14728222.7.2.175 |
0.475 |
|
| 2003 |
Maya-Núñez G, Conn PM. Transcriptional regulation of the GnRH receptor gene by glucocorticoids. Molecular and Cellular Endocrinology. 200: 89-98. PMID 12644302 DOI: 10.1016/S0303-7207(02)00419-7 |
0.482 |
|
| 2003 |
Janovick JA, Goulet M, Bush E, Greer J, Wettlaufer DG, Conn PM. Structure-activity relations of successful pharmacologic chaperones for rescue of naturally occurring and manufactured mutants of the gonadotropin-releasing hormone receptor. The Journal of Pharmacology and Experimental Therapeutics. 305: 608-14. PMID 12606630 DOI: 10.1124/jpet.102.048454 |
0.441 |
|
| 2003 |
Castro-Fernández C, Brothers SP, Conn PM. A Gαs mutation (D229S) differentially effects gonadotropin-releasing hormone receptor regulation by RGS10, RGS3 and RGS3T Molecular and Cellular Endocrinology. 200: 119-126. DOI: 10.1016/S0303-7207(02)00378-7 |
0.697 |
|
| 2002 |
Conn PM, Leaños-Miranda A, Janovick JA. Protein origami: therapeutic rescue of misfolded gene products. Molecular Interventions. 2: 308-16. PMID 14993385 DOI: 10.1124/mi.2.5.308 |
0.464 |
|
| 2002 |
Leaños-Miranda A, Janovick JA, Conn PM. Receptor-misrouting: an unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism. The Journal of Clinical Endocrinology and Metabolism. 87: 4825-8. PMID 12364481 DOI: 10.1210/Jc.2002-020961 |
0.557 |
|
| 2002 |
Cornea A, Conn PM. Measurement of changes in fluorescence resonance energy transfer between gonadotropin-releasing hormone receptors in response to agonists. Methods (San Diego, Calif.). 27: 333-9. PMID 12217649 |
0.408 |
|
| 2002 |
Janovick JA, Maya-Nunez G, Conn PM. Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target. The Journal of Clinical Endocrinology and Metabolism. 87: 3255-62. PMID 12107234 DOI: 10.1210/jcem.87.7.8582 |
0.518 |
|
| 2002 |
Castro-Fernández C, Conn PM. Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus. Molecular and Cellular Endocrinology. 191: 149-56. PMID 12062898 DOI: 10.1016/S0303-7207(02)00082-5 |
0.606 |
|
| 2002 |
Ji I, Lee C, Song Y, Conn PM, Ji TH. Cis- and trans-activation of hormone receptors: the LH receptor. Molecular Endocrinology (Baltimore, Md.). 16: 1299-308. PMID 12040016 DOI: 10.1210/mend.16.6.0852 |
0.515 |
|
| 2002 |
Timossi C, Maldonado D, VizcaÃno A, Lindau-Shepard B, Conn PM, Ulloa-Aguirre A. Structural determinants in the second intracellular loop of the human follicle-stimulating hormone receptor are involved in G(s) protein activation. Molecular and Cellular Endocrinology. 189: 157-68. PMID 12039074 |
0.386 |
|
| 2002 |
Brothers SP, Janovick JA, Maya-Nunez G, Cornea A, Han XB, Conn PM. Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization. Molecular and Cellular Endocrinology. 190: 19-27. PMID 11997175 DOI: 10.1016/S0303-7207(02)00040-0 |
0.732 |
|
| 2002 |
Maya-Núñez G, Janovick JA, Ulloa-Aguirre A, Söderlund D, Conn PM, Méndez JP. Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site. The Journal of Clinical Endocrinology and Metabolism. 87: 2144-9. PMID 11994356 DOI: 10.1210/jcem.87.5.8386 |
0.408 |
|
| 2002 |
Castro-Fernández C, Janovick JA, Brothers SP, Fisher RA, Ji TH, Conn PM. Regulation of RGS3 and RGS10 palmitoylation by GnRH. Endocrinology. 143: 1310-7. PMID 11897687 DOI: 10.1210/Endo.143.4.8713 |
0.697 |
|
| 2002 |
Lee C, Ji I, Ryu K, Song Y, Conn PM, Ji TH. Two defective heterozygous luteinizing hormone receptors can rescue hormone action. The Journal of Biological Chemistry. 277: 15795-800. PMID 11859079 DOI: 10.1074/jbc.M111818200 |
0.528 |
|
| 2001 |
Maya-Núñez G, Conn PM. Cyclic adenosine 3',5'-monophosphate (cAMP) and cAMP responsive element-binding protein are involved in the transcriptional regulation of gonadotropin-releasing hormone (GnRH) receptor by GnRH and mitogen-activated protein kinase signal transduction pathway in GGH(3) cells. Biology of Reproduction. 65: 561-7. PMID 11466226 |
0.365 |
|
| 2001 |
Cornea A, Janovick JA, Maya-Núñez G, Conn PM. Gonadotropin-releasing hormone receptor microaggregation. Rate monitored by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 276: 2153-8. PMID 11035030 DOI: 10.1074/jbc.M007850200 |
0.429 |
|
| 2000 |
Maya-Núñez G, Janovick JA, Conn PM. Combined modification of intracellular and extracellular loci on human gonadotropin-releasing hormone receptor provides a mechanism for enhanced expression. Endocrine. 13: 401-7. PMID 11216654 DOI: 10.1385/ENDO:13:3:401 |
0.446 |
|
| 2000 |
Frohman LA, Kineman RD, Kamegai J, Park S, Teixeira LT, Coschigano KT, Kopchick JJ, Mayo K, Hock J, Conn PM. Secretagogues and the somatotrope: Signaling and proliferation Recent Progress in Hormone Research. 55: 269-291. PMID 11036941 |
0.434 |
|
| 2000 |
Lin X, Janovick JA, Cardenas R, Conn PM, Peter RE. Molecular cloning and expression of a type-two somatostatin receptor in goldfish brain and pituitary. Molecular and Cellular Endocrinology. 166: 75-87. PMID 10996426 DOI: 10.1016/S0303-7207(00)00278-1 |
0.47 |
|
| 1999 |
Pinter JH, Janovick JA, Conn PM. Gonadotropin-releasing hormone receptor concentration differentially regulates intracellular signaling pathways in GGH3 cells. Pituitary. 2: 181-90. PMID 11081152 |
0.473 |
|
| 1999 |
Ulloa-Aguirre A, Stanislaus D, Janovick JA, Conn PM. Structure-activity relationships of G protein-coupled receptors. Archives of Medical Research. 30: 420-35. PMID 10714355 DOI: 10.1016/S0188-0128(99)00041-X |
0.477 |
|
| 1999 |
Lin X, Janovick JA, Brothers S, Conn PM, Peter RE. Molecular cloning and expression of two type one somatostatin receptors in goldfish brain. Endocrinology. 140: 5211-9. PMID 10537151 DOI: 10.1210/endo.140.11.7094 |
0.715 |
|
| 1999 |
Cornea A, Janovick JA, Lin X, Conn PM. Simultaneous and independent visualization of the gonadotropin-releasing hormone receptor and its ligand: evidence for independent processing and recycling in living cells. Endocrinology. 140: 4272-80. PMID 10465301 DOI: 10.1210/endo.140.9.7049 |
0.536 |
|
| 1999 |
Han XB, Conn PM. The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation. Endocrinology. 140: 2241-51. PMID 10218977 DOI: 10.1210/endo.140.5.6707 |
0.362 |
|
| 1998 |
Lin X, Cornea A, Janovick JA, Conn PM. Visualization of unoccupied and occupied gonadotropin-releasing hormone receptors in living cells. Molecular and Cellular Endocrinology. 146: 27-37. PMID 10022760 DOI: 10.1016/S0303-7207(98)00204-4 |
0.49 |
|
| 1998 |
Stanislaus D, Pinter JH, Janovick JA, Conn PM. Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone. Molecular and Cellular Endocrinology. 144: 1-10. PMID 9863622 DOI: 10.1016/S0303-7207(98)00126-9 |
0.429 |
|
| 1998 |
Lin X, Janovick JA, Conn PM. Mutations at the consensus phosphorylation sites in the third intracellular loop of the rat gonadotropin-releasing hormone receptor: effects on receptor ligand binding and signal transduction. Biology of Reproduction. 59: 1470-6. PMID 9828194 |
0.45 |
|
| 1998 |
Stanislaus D, Ponder S, Ji TH, Conn PM. Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: evidence from palmitoylation and overexpression of G proteins. Biology of Reproduction. 59: 579-86. PMID 9716556 DOI: 10.1095/BIOLREPROD59.3.579 |
0.509 |
|
| 1998 |
Ulloa-Aguirre A, Stanislaus D, Arora V, Väänänen J, Brothers S, Janovick JA, Conn PM. The third intracellular loop of the rat gonadotropin-releasing hormone receptor couples the receptor to Gs- and G(q/11)-mediated signal transduction pathways: evidence from loop fragment transfection in GGH3 cells. Endocrinology. 139: 2472-8. PMID 9564860 DOI: 10.1210/endo.139.5.6022 |
0.752 |
|
| 1998 |
Lin X, Janovick JA, Brothers S, Blömenrohr M, Bogerd J, Conn PM. Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation. Molecular Endocrinology (Baltimore, Md.). 12: 161-71. PMID 9482659 DOI: 10.1210/mend.12.2.0056 |
0.742 |
|
| 1997 |
Jennes L, Eyigor O, Janovick JA, Conn PM. Brain gonadotropin releasing hormone receptors: localization and regulation. Recent Progress in Hormone Research. 52: 475-90; discussion 4. PMID 9238864 |
0.458 |
|
| 1997 |
Stanislaus D, Janovick JA, Brothers S, Conn PM. Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor. Molecular Endocrinology (Baltimore, Md.). 11: 738-46. PMID 9171237 DOI: 10.1210/mend.11.6.0005 |
0.676 |
|
| 1997 |
Kaiser UB, Conn PM, Chin WW. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines. Endocrine Reviews. 18: 46-70. PMID 9034786 DOI: 10.1210/Edrv.18.1.0289 |
0.394 |
|
| 1996 |
Janovick JA, Conn PM. Gonadotropin releasing hormone agonist provokes homologous receptor microaggregation: an early event in seven-transmembrane receptor mediated signaling. Endocrinology. 137: 3602-5. PMID 8754794 DOI: 10.1210/endo.137.8.8754794 |
0.502 |
|
| 1996 |
Conn PM, Bowers CY. A new receptor for growth hormone-release peptide. Science (New York, N.Y.). 273: 923. PMID 8711477 |
0.313 |
|
| 1996 |
Stanislaus D, Arora V, Awara WM, Conn PM. Biphasic action of cyclic adenosine 3',5'- monophosphate in gonadotropin-releasing hormone (GnRH) analog-stimulated hormone release from GH3 cells stably transfected with GnRH receptor complementary deoxyribonucleic acid. Endocrinology. 137: 1025-31. PMID 8603570 DOI: 10.1210/endo.137.3.8603570 |
0.326 |
|
| 1996 |
Awara WM, Guo CH, Conn PM. Effects of Asn318 and Asp87Asn318 mutations on signal transduction by the gonadotropin-releasing hormone receptor and receptor regulation. Endocrinology. 137: 655-62. PMID 8593815 DOI: 10.1210/endo.137.2.8593815 |
0.429 |
|
| 1995 |
Jennes L, Brame B, Centers A, Janovick JA, Conn PM. Regulation of hippocampal gonadotropin releasing hormone (GnRH) receptor mRNA and GnRH-stimulated inositol phosphate production by gonadal steroid hormones. Brain Research. Molecular Brain Research. 33: 104-10. PMID 8774951 |
0.319 |
|
| 1995 |
Kaiser UB, Sabbagh E, Katzenellenbogen RA, Conn PM, Chin WW. A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone. Proceedings of the National Academy of Sciences of the United States of America. 92: 12280-4. PMID 8618885 DOI: 10.1073/Pnas.92.26.12280 |
0.342 |
|
| 1995 |
Janovick JA, Jennes L, Conn PM. GH3 cells transfected with gonadotropin-releasing hormone (GnRH) receptor complementary deoxyribonucleic acid release secretogranin-II through a constitutive pathway after GnRH analog-regulated synthesis: evidence that secretory proteins do not contain a sequence that obligates processing through a secretory granule or by regulated secretion. Endocrinology. 136: 202-8. PMID 7828532 DOI: 10.1210/endo.136.1.7828532 |
0.391 |
|
| 1995 |
Guo CH, Janovick JA, Kuphal D, Conn PM. Transient transfection of GGH3-1' cells [GH3 cells stably transfected with the gonadotropin-releasing hormone (GnRH) receptor complementary deoxyribonucleic acid] with the carboxyl-terminal of beta-adrenergic receptor kinase 1 blocks prolactin release: evidence for a role of the G protein beta gamma-subunit complex in GnRH signal transduction. Endocrinology. 136: 3031-6. PMID 7789329 DOI: 10.1210/endo.136.7.7789329 |
0.328 |
|
| 1994 |
Kuphal D, Janovick JA, Kaiser UB, Chin WW, Conn PM. Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein. Endocrinology. 135: 315-20. PMID 8013367 DOI: 10.1210/Endo.135.1.8013367 |
0.537 |
|
| 1994 |
Jennes L, Conn PM. Gonadotropin-releasing hormone and its receptors in rat brain. Frontiers in Neuroendocrinology. 15: 51-77. PMID 7958169 DOI: 10.1006/frne.1994.1003 |
0.391 |
|
| 1994 |
Stanislaus D, Janovick JA, Jennes L, Kaiser UB, Chin WW, Conn PM. Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid. Endocrinology. 135: 2220-7. PMID 7956945 DOI: 10.1210/Endo.135.5.7956945 |
0.357 |
|
| 1994 |
Janovick JA, Conn PM. Gonadotropin-releasing hormone (GnRH)-receptor coupling to inositol phosphate and prolactin production in GH3 cells stably transfected with rat GnRH receptor complementary deoxyribonucleic acid. Endocrinology. 135: 2214-9. PMID 7956944 DOI: 10.1210/endo.135.5.7956944 |
0.318 |
|
| 1994 |
Kaiser UB, Katzenellenbogen RA, Conn PM, Chin WW. Evidence that signalling pathways by which thyrotropin-releasing hormone and gonadotropin-releasing hormone act are both common and distinct. Molecular Endocrinology (Baltimore, Md.). 8: 1038-48. PMID 7527898 DOI: 10.1210/Mend.8.8.7527898 |
0.456 |
|
| 1993 |
Hawes BE, Conn PM. Assessment of the role of G proteins and inositol phosphate production in the action of gonadotropin-releasing hormone. Clinical Chemistry. 39: 325-32. PMID 8432023 |
0.315 |
|
| 1993 |
Janovick JA, Conn PM. A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone. Endocrinology. 132: 2131-5. PMID 8386609 DOI: 10.1210/endo.132.5.8386609 |
0.306 |
|
| 1993 |
Hawes BE, Barnes S, Conn PM. Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: evidence for multiple guanyl nucleotide binding proteins in GnRH action. Endocrinology. 132: 2124-30. PMID 8386608 DOI: 10.1210/endo.132.5.8386608 |
0.426 |
|
| 1992 |
Hawes BE, Conn PM. Development of gonadotrope desensitization to gonadotropin-releasing hormone (GnRH) and recovery are not coupled to inositol phosphate production or GnRH receptor number. Endocrinology. 131: 2681-9. PMID 1332845 DOI: 10.1210/endo.131.6.1332845 |
0.325 |
|
| 1992 |
Hawes BE, Marzen JE, Waters SB, Conn PM. Sodium fluoride provokes gonadotrope desensitization to gonadotropin-releasing hormone (GnRH) and gonadotrope sensitization to A23187: evidence for multiple G proteins in GnRH action. Endocrinology. 130: 2465-75. PMID 1315244 DOI: 10.1210/endo.130.5.1315244 |
0.392 |
|
| 1992 |
Braden TD, Conn PM. Activin-A stimulates the synthesis of gonadotropin-releasing hormone receptors. Endocrinology. 130: 2101-5. PMID 1312442 DOI: 10.1210/endo.130.4.1312442 |
0.461 |
|
| 1991 |
Braden TD, Conn PM. The 1990 James A. F. Stevenson Memorial Lecture. Gonadotropin-releasing hormone and its actions. Canadian Journal of Physiology and Pharmacology. 69: 445-58. PMID 2059907 |
0.449 |
|
| 1991 |
Waters SB, Conn PM. Regulation of the pituitary gonadotrope by gonadotropin-releasing hormone: multiple intracellular effectors. The Chinese Journal of Physiology. 34: 1-26. PMID 1908369 |
0.36 |
|
| 1991 |
Braden TD, Bervig T, Conn PM. Protein kinase-C activation stimulates synthesis of gonadotropin-releasing hormone (GnRH) receptors, but does not mediate GnRH-stimulated receptor synthesis. Endocrinology. 129: 2486-90. PMID 1657576 DOI: 10.1210/endo-129-5-2486 |
0.468 |
|
| 1990 |
Jennes L, Janovick J, Braden T, Conn PM. Gonadotropin releasing hormone binding sites in rat hippocampus: Different structure/binding relationships compared to the anterior pituitary. Molecular and Cellular Neurosciences. 1: 121-7. PMID 19912761 DOI: 10.1016/1044-7431(90)90015-V |
0.364 |
|
| 1990 |
Andrews WV, Hansen JR, Janovick JA, Conn PM. Gonadotropin-releasing hormone modulation of protein kinase-C activity in perifused anterior pituitary cell cultures. Endocrinology. 127: 2393-9. PMID 2171914 DOI: 10.1210/endo-127-5-2393 |
0.331 |
|
| 1990 |
Braden TD, Farnworth PG, Burger HG, Conn PM. Regulation of the synthetic rate of gonadotropin-releasing hormone receptors in rat pituitary cell cultures by inhibin. Endocrinology. 127: 2387-92. PMID 2171913 DOI: 10.1210/endo-127-5-2387 |
0.487 |
|
| 1990 |
Braden TD, Conn PM. Altered rate of synthesis of gonadotropin-releasing hormone receptors: effects of homologous hormone appear independent of extracellular calcium. Endocrinology. 126: 2577-82. PMID 2158430 DOI: 10.1210/endo-126-5-2577 |
0.446 |
|
| 1989 |
Braden TD, Hawes BE, Conn PM. Synthesis of gonadotropin-releasing hormone receptors by gonadotrope cell cultures: both preexisting receptors and those unmasked by protein kinase-C activators show a similar synthetic rate. Endocrinology. 125: 1623-9. PMID 2547592 DOI: 10.1210/endo-125-3-1623 |
0.512 |
|
| 1989 |
Huckle WR, Hawes BE, Conn PM. Protein kinase C-mediated gonadotropin-releasing hormone receptor sequestration is associated with uncoupling of phosphoinositide hydrolysis. The Journal of Biological Chemistry. 264: 8619-26. PMID 2542281 |
0.42 |
|
| 1988 |
De Leeuw R, Conn PM, Van't Veer C, Goos HJ, Van Oordt PG. Characterization of the receptor for gonadotropin-releasing hormone in the pituitary of the African catfish,Clarias gariepinus. Fish Physiology and Biochemistry. 5: 99-107. PMID 24226622 DOI: 10.1007/BF01875646 |
0.416 |
|
| 1988 |
Hazum E, Conn PM. Molecular mechanism of gonadotropin releasing hormone (GnRH) action. I. The GnRH receptor. Endocrine Reviews. 9: 379-86. PMID 2851440 DOI: 10.1210/edrv-9-4-379 |
0.39 |
|
| 1988 |
Huckle WR, McArdle CA, Conn PM. Differential sensitivity of agonist- and antagonist-occupied gonadotropin-releasing hormone receptors to protein kinase C activators. A marker for receptor activation. The Journal of Biological Chemistry. 263: 3296-302. PMID 2830280 |
0.458 |
|
| 1987 |
Gorospe WC, Conn PM. Agents that decrease gonadotropin-releasing hormone (GnRH) receptor internalization do not inhibit GnRH-mediated gonadotrope desensitization. Endocrinology. 120: 222-9. PMID 3023028 DOI: 10.1210/endo-120-1-222 |
0.396 |
|
| 1987 |
McArdle CA, Gorospe WC, Huckle WR, Conn PM. Homologous down-regulation of gonadotropin-releasing hormone receptors and desensitization of gonadotropes: lack of dependence on protein kinase C. Molecular Endocrinology (Baltimore, Md.). 1: 420-9. PMID 2856305 DOI: 10.1210/mend-1-6-420 |
0.432 |
|
| 1987 |
Conn PM, Staley DD, Yasumoto T, Huckle WR, Janovick JA. Homologous desensitization with gonadotropin-releasing hormone (GnRH) also diminishes gonadotrope responsiveness to maitotoxin: a role for the GnRH receptor-regulated calcium ion channel in mediation of cellular desensitization. Molecular Endocrinology (Baltimore, Md.). 1: 154-9. PMID 2457798 DOI: 10.1210/mend-1-2-154 |
0.302 |
|
| 1986 |
Andrews WV, Staley DD, Huckle WR, Conn PM. Stimulation of luteinizing hormone (LH) release and phospholipid breakdown by guanosine triphosphate in permeabilized pituitary gonadotropes: antagonist action suggests association of a G protein and gonadotropin-releasing hormone receptor. Endocrinology. 119: 2537-46. PMID 3023016 DOI: 10.1210/endo-119-6-2537 |
0.393 |
|
| 1986 |
Jennes L, Coy D, Conn PM. Receptor-mediated uptake of GnRH agonist and antagonists by cultured gonadotropes: evidence for differential intracellular routing. Peptides. 7: 459-63. PMID 3022254 |
0.373 |
|
| 1986 |
Leiser J, Conn PM, Blum JJ. Interpretation of dose-response curves for luteinizing hormone release by gonadotropin-releasing hormone, related peptides, and leukotriene C4 according to a hormone/receptor/effector model. Proceedings of the National Academy of Sciences of the United States of America. 83: 5963-7. PMID 3016732 |
0.317 |
|
| 1986 |
Jennes L, Conn PM, Stumff WE. Synthesis and use of colloidal gold-coupled receptor ligands. Methods in Enzymology. 124: 36-47. PMID 3012251 |
0.322 |
|
| 1986 |
Conn PM, Staley D, Harris C, Andrews WV, Gorospe WC, McArdle CA, Huckle WR, Hansen J. Mechanism of action of gonadotropin releasing hormone. Annual Review of Physiology. 48: 495-513. PMID 3010823 DOI: 10.1146/annurev.ph.48.030186.002431 |
0.452 |
|
| 1985 |
Harris CE, Staley D, Conn PM. Diacylglycerols and protein kinase C. Potential amplifying mechanism for Ca2+-mediated gonadotropin-releasing hormone-stimulated luteinizing hormone release. Molecular Pharmacology. 27: 532-6. PMID 3157862 |
0.3 |
|
| 1985 |
Conn PM, Staley D, Jinnah H, Bates M. Molecular mechanism of gonadotropin releasing hormone action. Journal of Steroid Biochemistry. 23: 703-10. PMID 3001414 DOI: 10.1016/S0022-4731(85)80005-4 |
0.37 |
|
| 1985 |
Conn PM, Rogers DC, Seay SG, Jinnah H, Bates M, Luscher D. Regulation of gonadotropin release, GnRH receptors, and gonadotrope responsiveness: a role for GnRH receptor microaggregation. Journal of Cellular Biochemistry. 27: 13-21. PMID 2984221 DOI: 10.1002/jcb.240270103 |
0.477 |
|
| 1985 |
Jennes L, Bronson D, Stumpf WE, Conn PM. Evidence for an association between calmodulin and membrane patches containing gonadotropin-releasing hormone--receptor complexes in cultured gonadotropes. Cell and Tissue Research. 239: 311-5. PMID 2983896 DOI: 10.1007/BF00218009 |
0.387 |
|
| 1984 |
Conn PM, Rogers DC, Seay SG. Biphasic regulation of the gonadotropin-releasing hormone receptor by receptor microaggregation and intracellular Ca2+ levels. Molecular Pharmacology. 25: 51-5. PMID 6323952 |
0.428 |
|
| 1984 |
Jennes L, Stumpf WE, Conn PM. Receptor-mediated binding and uptake of GnRH agonist and antagonist by pituitary cells. Peptides. 5: 215-20. PMID 6091067 |
0.427 |
|
| 1983 |
Conn PM. Ligand dimerization: a technique for assessing receptor-receptor interactions. Methods in Enzymology. 103: 49-58. PMID 6321894 |
0.378 |
|
| 1983 |
Marian J, Conn PM. Subcellular localization of the receptor for gonadotropin-releasing hormone in pituitary and ovarian tissue. Endocrinology. 112: 104-12. PMID 6291912 DOI: 10.1210/endo-112-1-104 |
0.36 |
|
| 1982 |
Blum JJ, Conn PM. Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model. Proceedings of the National Academy of Sciences of the United States of America. 79: 7307-11. PMID 6296828 |
0.359 |
|
| 1982 |
Conn PM, Rogers DC, McNeil R. Potency enhancement of a GnRH agonist: GnRH-receptor microaggregation stimulates gonadotropin release. Endocrinology. 111: 335-7. PMID 6282571 DOI: 10.1210/endo-111-1-335 |
0.367 |
|
| 1982 |
Conn PM, Rogers DC, Stewart JM, Niedel J, Sheffield T. Conversion of a gonadotropin-releasing hormone antagonist to an agonist. Nature. 296: 653-5. PMID 6280058 |
0.312 |
|
| 1981 |
Conn PM, Hazum E. Luteinizing hormone release and gonadotropin-releasing hormone (GnRH) receptor internalization: independent actions of GnRH. Endocrinology. 109: 2040-5. PMID 6273126 DOI: 10.1210/endo-109-6-2040 |
0.35 |
|
| 1981 |
Marian J, Cooper RL, Conn PM. Regulation of the rat pituitary gonadotropin-releasing hormone receptor. Molecular Pharmacology. 19: 399-405. PMID 6267446 |
0.401 |
|
| 1980 |
Hazum E, Cuatrecasas P, Marian J, Conn PM. Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes. Proceedings of the National Academy of Sciences of the United States of America. 77: 6692-5. PMID 6256756 |
0.384 |
|
| 1980 |
Marian J, Conn PM. The calcium requirement in GnRH-stimulated LH release is not mediated through a specific action on receptor binding. Life Sciences. 27: 87-92. PMID 6249994 |
0.355 |
|
| 1979 |
Catt KJ, Harwood JP, Richert ND, Conn PM, Conti M, Dufau ML. Luteal desensitization: hormonal regulation of LH receptors, adenylate cyclase and steroidogenic responses in the luteal cell. Advances in Experimental Medicine and Biology. 112: 647-62. PMID 223402 DOI: 10.1007/978-1-4684-3474-3_72 |
0.435 |
|
| 1978 |
Harwood JP, Conti M, Conn PM, Dufau ML, Catt KJ. Receptor regulation and target cell responses: studies in the ovarian luteal cell. Molecular and Cellular Endocrinology. 11: 121-35. PMID 210062 |
0.311 |
|
| 1978 |
Conn PM, Conti M, Harwood JP, Dufau ML, Catt KJ. Internalisation of gonadotrophin--receptor complex in ovarian luteal cells. Nature. 274: 598-600. PMID 209335 |
0.334 |
|
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