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Claes Wahlestedt - Publications

Affiliations: 
Neuroscience Scripps Florida, Jupiter, FL, United States 
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34/342 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Dennison JL, Al-Ali H, Volmar CH, Brothers S, Watts J, Wahlestedt C, Lohse I. Functional Drug Screening of Small Molecule Inhibitors of Epigenetic Modifiers in Refractory AML Patients. Cancers. 14. PMID 36077629 DOI: 10.3390/cancers14174094  0.652
2022 Kemper C, Benham D, Brothers S, Wahlestedt C, Volmar CH, Bennett D, Hayward M. Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL ). Aaps Open. 8: 11. PMID 35789594 DOI: 10.1186/s41120-022-00058-1  0.605
2022 Dennison JL, Volmar CH, Modarresi F, Ke D, Wang J, Gravel E, Hammond-Vignini S, Li Z, Timmons JA, Lohse I, Hayward MA, Brothers SP, Wahlestedt C. Erratum to: JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model. Journal of Alzheimer's Disease : Jad. PMID 35723129 DOI: 10.3233/JAD-229006  0.597
2022 Dennison JL, Volmar CH, Ke D, Wang J, Gravel E, Hammond-Vignini S, Li Z, Timmons JA, Lohse I, Hayward MA, Brothers SP, Wahlestedt C. JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model. Journal of Alzheimer's Disease : Jad. PMID 35034905 DOI: 10.3233/JAD-215370  0.617
2022 Khalafi S, Zhu S, Khurana R, Lohse I, Giordano S, Corso S, Al-Ali H, Brothers SP, Wahlestedt C, Schürer S, El-Rifai W. A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer. Translational Oncology. 15: 101260. PMID 34735897 DOI: 10.1016/j.tranon.2021.101260  0.638
2020 Kuznetsoff JN, Owens DA, Lopez A, Rodriguez DA, Chee NT, Kurtenbach S, Bilbao D, Roberts ER, Volmar CH, Wahlestedt C, Brothers SP, Harbour JW. Dual screen for efficacy and toxicity identifies HDAC inhibitor with distinctive activity spectrum for BAP1-mutant uveal melanoma. Molecular Cancer Research : McR. PMID 33077485 DOI: 10.1158/1541-7786.MCR-20-0434  0.639
2019 Lohse I, Azzam DJ, Al-Ali H, Volmar CH, Brothers SP, Ince TA, Wahlestedt C. Ovarian Cancer Treatment Stratification Using Drug Sensitivity Testing. Anticancer Research. 39: 4023-4030. PMID 31366484 DOI: 10.21873/Anticanres.13558  0.621
2019 Mustafi S, Camarena V, Qureshi R, Yoon H, Volmar CH, Huff TC, Sant DW, Zheng L, Brothers SP, Wahlestedt C, Slingerland J, Wang G. Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer. Ebiomedicine. PMID 30975544 DOI: 10.1016/J.Ebiom.2019.04.006  0.602
2019 Bagheri A, Habibzadeh P, Razavipour SF, Volmar CH, Chee NT, Brothers SP, Wahlestedt C, Mowla SJ, Faghihi MA. HDAC Inhibitors Induce Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons. International Journal of Molecular Sciences. 20. PMID 30841499 DOI: 10.3390/ijms20051109  0.633
2018 Copsel SN, Lightbourn CO, Barreras H, Lohse I, Wolf D, Bader CS, Manov J, Kale BJ, Shah D, Brothers SP, Perez VL, Komanduri KV, Wahlestedt C, Levy RB. BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT. Frontiers in Immunology. 9: 3104. PMID 30733722 DOI: 10.3389/fimmu.2018.03104  0.63
2018 Lohse I, Statz-Geary K, Brothers SP, Wahlestedt C. Precision medicine in the treatment stratification of AML patients: challenges and progress. Oncotarget. 9: 37790-37797. PMID 30701032 DOI: 10.18632/oncotarget.26492  0.627
2018 Janczura KJ, Volmar CH, Sartor GC, Rao SJ, Ricciardi NR, Lambert G, Brothers SP, Wahlestedt C. Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model. Proceedings of the National Academy of Sciences of the United States of America. PMID 30397132 DOI: 10.1073/Pnas.1805436115  0.62
2018 Lohse I, Al-Ali H, Volmar CH, D Alvarez Trotta A, Brothers SP, Capobianco AJ, Wahlestedt C. Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma. Plos One. 13: e0203173. PMID 30212533 DOI: 10.1371/Journal.Pone.0203173  0.622
2018 Johnstone AL, O'Reilly JJ, Patel AJ, Guo Z, Andrade NS, Magistri M, Nathanson L, Esanov R, Miller BH, Turecki G, Brothers SP, Zeier Z, Wahlestedt C. Enhancer of Zeste 1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia. Neurobiology of Disease. PMID 30099093 DOI: 10.1016/J.Nbd.2018.08.005  0.596
2017 Mustafi S, Camarena V, Volmar CH, Huff TC, Sant DW, Brothers SP, Liu ZJ, Wahlestedt C, Wang G. Vitamin C sensitizes melanoma to BET inhibitors. Cancer Research. PMID 29180474 DOI: 10.1158/0008-5472.Can-17-2040  0.651
2017 Swords RT, Azzam D, Al-Ali H, Lohse I, Volmar CH, Watts JM, Perez A, Rodriguez A, Vargas F, Elias R, Vega F, Zelent A, Brothers SP, Abbasi T, Trent J, ... Wahlestedt C, et al. Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study. Leukemia Research. 64: 34-41. PMID 29175379 DOI: 10.1016/J.Leukres.2017.11.008  0.629
2017 Volmar CH, Salah-Uddin H, Janczura KJ, Halley P, Lambert G, Wodrich A, Manoah S, Patel NH, Sartor GC, Mehta N, Miles NTH, Desse S, Dorcius D, Cameron MD, Brothers SP, Wahlestedt C, et al. M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory. Proceedings of the National Academy of Sciences of the United States of America. 114: E9135-E9144. PMID 29073110 DOI: 10.1073/Pnas.1707544114  0.631
2017 Jones C, Barrera I, Brothers S, Ring R, Wahlestedt C. Oxytocin and social functioning. Dialogues in Clinical Neuroscience. 19: 193-201. PMID 28867943  0.586
2016 Aziz AM, Brothers S, Sartor G, Holm L, Heilig M, Wahlestedt C, Thorsell A. The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models. Psychopharmacology. PMID 27515665 DOI: 10.1016/J.Alcohol.2017.02.313  0.579
2016 Volmar CH, Wahlestedt C, Brothers SP. Orphan diseases: state of the drug discovery art. Wiener Medizinische Wochenschrift (1946). PMID 26819216 DOI: 10.1007/s10354-015-0423-0  0.613
2015 Sartor GC, Powell SK, Wiedner HJ, Wahlestedt C, Brothers SP. "Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice". Brain Research. PMID 26657743 DOI: 10.1016/J.Brainres.2015.11.044  0.597
2015 Sartor GC, Powell SK, Brothers SP, Wahlestedt C. Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15062-72. PMID 26558777 DOI: 10.1523/Jneurosci.0826-15.2015  0.609
2015 Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, Wahlestedt C, et al. Bromodomain inhibitors regulate the C9ORF72 locus in ALS. Experimental Neurology. 271: 241-50. PMID 26099177 DOI: 10.1016/J.Expneurol.2015.06.017  0.659
2015 Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, Wahlestedt C, et al. Bromodomain inhibitors regulate the C9ORF72 locus in ALS Experimental Neurology. 271: 241-250. DOI: 10.1016/j.expneurol.2015.06.017  0.596
2014 Carlsson SK, Brothers SP, Wahlestedt C. Emerging treatment strategies for glioblastoma multiforme. Embo Molecular Medicine. 6: 1359-70. PMID 25312641 DOI: 10.15252/Emmm.201302627  0.612
2014 Barrett E, Brothers S, Wahlestedt C, Beurel E. I-BET151 selectively regulates IL-6 production. Biochimica Et Biophysica Acta. 1842: 1549-55. PMID 24859008 DOI: 10.1016/J.Bbadis.2014.05.013  0.605
2014 Pastori C, Daniel M, Penas C, Volmar CH, Johnstone AL, Brothers SP, Graham RM, Allen B, Sarkaria JN, Komotar RJ, Wahlestedt C, Ayad NG. BET bromodomain proteins are required for glioblastoma cell proliferation. Epigenetics : Official Journal of the Dna Methylation Society. 9: 611-20. PMID 24496381 DOI: 10.4161/Epi.27906  0.638
2013 Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ. Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD. Science Translational Medicine. 5: 188ra73. PMID 23740899 DOI: 10.1126/Scitranslmed.3005656  0.588
2012 Mittapalli GK, Vellucci D, Yang J, Toussaint M, Brothers SP, Wahlestedt C, Roberts E. Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 22: 3916-20. PMID 22607676 DOI: 10.1016/J.Bmcl.2012.04.107  0.6
2012 Modarresi F, Faghihi MA, Lopez-Toledano MA, Fatemi RP, Magistri M, Brothers SP, van der Brug MP, Wahlestedt C. Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nature Biotechnology. 30: 453-9. PMID 22446693 DOI: 10.1038/Nbt.2158  0.632
2010 Brothers SP, Wahlestedt C. Therapeutic potential of neuropeptide Y (NPY) receptor ligands. Embo Molecular Medicine. 2: 429-39. PMID 20972986 DOI: 10.1002/Emmm.201000100  0.611
2010 Faghihi MA, Kocerha J, Modarresi F, Engström PG, Chalk AM, Brothers SP, Koesema E, St Laurent G, Wahlestedt C. RNAi screen indicates widespread biological function for human natural antisense transcripts. Plos One. 5. PMID 20957177 DOI: 10.1371/Journal.Pone.0013177  0.621
2010 Brothers SP, Saldanha SA, Spicer TP, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Molecular Pharmacology. 77: 46-57. PMID 19837904 DOI: 10.1124/Mol.109.058677  0.621
2008 Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C. A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. Plos One. 3: e1486. PMID 18213394 DOI: 10.1371/Journal.Pone.0001486  0.619
Low-probability matches (unlikely to be authored by this person)
2014 Johnstone S, Johhnsone A, Penas C, Stathias V, Brothers S, Ayad N, Wahlestedt C, Albert J. EG-04 * DEVELOPMENT OF HIGHLY POTENT, SELECTIVE BET BROMODOMAIN INHIBITORS THAT ARE CNS PENETRANT AND EFFECTIVE IN RODENT MODELS OF BRAIN CANCER Neuro-Oncology. 16: v75-v75. DOI: 10.1093/Neuonc/Nou254.4  0.273
2015 Pastori C, Kapranov P, Penas C, Peschansky V, Volmar CH, Sarkaria JN, Bregy A, Komotar R, St Laurent G, Ayad NG, Wahlestedt C. The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation. Proceedings of the National Academy of Sciences of the United States of America. 112: 8326-31. PMID 26111795 DOI: 10.1073/Pnas.1424220112  0.265
2018 Stathias V, Jermakowicz AM, Maloof ME, Forlin M, Walters W, Suter RK, Durante MA, Williams SL, Harbour JW, Volmar CH, Lyons NJ, Wahlestedt C, Graham RM, Ivan ME, Komotar RJ, et al. Drug and disease signature integration identifies synergistic combinations in glioblastoma. Nature Communications. 9: 5315. PMID 30552330 DOI: 10.1038/S41467-018-07659-Z  0.253
2014 Pastori C, Kapranov P, Penas C, Laurent GS, Ayad N, Wahlestedt C. EG-10 * LONG NON-CODING RNAs IN GLIOBLASTOMA Neuro-Oncology. 16: v77-v77. DOI: 10.1093/Neuonc/Nou254.10  0.25
2018 Sartor GC, Malvezzi AM, Kumar A, Andrade NS, Wiedner HJ, Vilca SJ, Janczura KJ, Bagheri A, Al-Ali H, Powell SK, Brown PT, Volmar CH, Foster TC, Zeier Z, Wahlestedt C. Enhancement of BDNF expression and memory by HDAC inhibition requires BET bromodomain reader proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30504275 DOI: 10.1523/Jneurosci.1604-18.2018  0.247
2023 Ricciardi NR, Modarresi F, Lohse I, Andrade NS, Newman IR, Brown JM, Borja C, Marples B, Wahlestedt CR, Volmar CH. Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer's Disease Models. Molecular Neurobiology. PMID 37171575 DOI: 10.1007/s12035-023-03373-0  0.238
2014 Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ. The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers. The Journal of Biological Chemistry. 289: 35494-502. PMID 25355313 DOI: 10.1074/Jbc.M114.595348  0.234
2015 Azzam D, Volmar C, Hassan A, Perez A, Watts JM, Vargas F, Elias R, Vega F, Zelent A, Cogle CR, Wahlestedt C, Swords RT. A Patient-Specific Ex Vivo Screening Platform for Personalized Acute Myeloid Leukemia (AML) Therapy Blood. 126: 1352-1352. DOI: 10.1182/Blood.V126.23.1352.1352  0.233
2016 Witt AE, Lee CW, Lee TI, Azzam DJ, Wang B, Caslini C, Petrocca F, Grosso J, Jones M, Cohick EB, Gropper AB, Wahlestedt C, Richardson AL, Shiekhattar R, Young RA, et al. Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer. Oncogene. PMID 27694895 DOI: 10.1038/Onc.2016.337  0.23
2013 Wahlestedt C. Targeting long non-coding RNA to therapeutically upregulate gene expression. Nature Reviews. Drug Discovery. 12: 433-46. PMID 23722346 DOI: 10.1038/nrd4018  0.229
2022 Timmons JA, Anighoro A, Brogan RJ, Stahl J, Wahlestedt C, Farquhar DG, Taylor-King J, Volmar CH, Kraus WE, Phillips SM. A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease. Elife. 11. PMID 35037854 DOI: 10.7554/eLife.68832  0.224
2020 Alvarez-Trotta A, Wang Z, Shersher E, Li B, Long J, Lohse I, Wahlestedt C, El-Rifai W, Robbins DJ, Capobianco AJ. The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling. Oncotarget. 11: 3174-3187. PMID 32913560 DOI: 10.18632/Oncotarget.27699  0.223
2015 Pedram Fatemi R, Salah-Uddin S, Modarresi F, Khoury N, Wahlestedt C, Faghihi MA. Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. Journal of Biomolecular Screening. 20: 1132-41. PMID 26173710 DOI: 10.1177/1087057115594187  0.222
2015 Yamanaka Y, Faghihi MA, Magistri M, Alvarez-Garcia O, Lotz M, Wahlestedt C. Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2. Cell Reports. 11: 967-76. PMID 25937287 DOI: 10.1016/J.Celrep.2015.04.011  0.221
2015 Swords RT, Brothers S, Ayad N, Perez A, Watts JM, Vargas F, Elias R, Rodriguez A, Johnstone S, Albert J, Collard J, Zelent A, Wahlestedt C. The BET Bromodomain Inhibitors EP11313 and EP11336 Have Potent Anti-Leukemic Activity in Acute Myeloid Leukemia (AML) and Augment the Effects of All-Trans-Retinoic Acid (AtRA) in Vitro Blood. 126: 2552-2552. DOI: 10.1182/Blood.V126.23.2552.2552  0.221
2018 Blokhin I, Khorkova O, Hsiao J, Wahlestedt C. Developments in lncRNA drug discovery: where are we heading? Expert Opinion On Drug Discovery. 1-13. PMID 30078338 DOI: 10.1080/17460441.2018.1501024  0.219
2023 Khorkova O, Stahl J, Joji A, Volmar CH, Wahlestedt C. Amplifying gene expression with RNA-targeted therapeutics. Nature Reviews. Drug Discovery. PMID 37253858 DOI: 10.1038/s41573-023-00704-7  0.215
2016 Peschansky VJ, Pastori C, Zeier Z, Wentzel K, Velmeshev D, Magistri M, Silva JP, Wahlestedt C. The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans. Molecular and Cellular Neurosciences. PMID 27001315 DOI: 10.1016/j.mcn.2016.03.008  0.214
2017 Yang H, Kurtenbach S, Guo Y, Lohse I, Durante MA, Li J, Li Z, Al-Ali H, Li L, Chen Z, Field MG, Zhang P, Chen S, Yamamoto S, Li Z, ... Wahlestedt C, et al. Gain-of-function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies. Blood. PMID 29113963 DOI: 10.1182/Blood-2017-06-789669  0.212
2017 Sartor GC, Powell SK, Velmeshev D, Lin DY, Magistri M, Wiedner HJ, Malvezzi AM, Andrade NS, Faghihi MA, Wahlestedt C. Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens. Molecular and Cellular Neurosciences. PMID 29055697 DOI: 10.1016/J.Mcn.2017.10.003  0.211
2023 Dennison J, Mendez A, Szeto A, Lohse I, Wahlestedt C, Volmar CH. Low-Dose Chidamide Treatment Displays Sex-Specific Differences in the 3xTg-AD Mouse. Biomolecules. 13. PMID 37759724 DOI: 10.3390/biom13091324  0.211
2006 Zhang HY, Du Q, Wahlestedt C, Liang Z. RNA Interference with chemically modified siRNA. Current Topics in Medicinal Chemistry. 6: 893-900. PMID 16787282 DOI: 10.2174/156802606777303676  0.208
2012 Sartor GC, St Laurent G, Wahlestedt C. The Emerging Role of Non-Coding RNAs in Drug Addiction. Frontiers in Genetics. 3: 106. PMID 22737160 DOI: 10.3389/Fgene.2012.00106  0.207
2014 Halley P, Kadakkuzha BM, Faghihi MA, Magistri M, Zeier Z, Khorkova O, Coito C, Hsiao J, Lawrence M, Wahlestedt C. Regulation of the apolipoprotein gene cluster by a long noncoding RNA. Cell Reports. 6: 222-30. PMID 24388749 DOI: 10.1016/J.Celrep.2013.12.015  0.206
2020 Spriano F, Gaudio E, Cascione L, Tarantelli C, Melle F, Motta G, Priebe V, Rinaldi A, Golino G, Mensah AA, Aresu L, Zucca E, Pileri S, Witcher M, Brown B, Wahlestedt C, et al. Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734. Blood Advances. 4: 4124-4135. PMID 32882003 DOI: 10.1182/Bloodadvances.2020001879  0.205
2019 Copsel S, Lightbourn CO, Barreras H, Lohse I, Wolf D, Bader CS, Manov J, Kale B, Shah D, Brothers S, Perez VL, Komanduri KV, Wahlestedt C, Levy RB. Identification of a BET Bromodomain Inhibitor That Enables Treg Function: A Combinatorial Strategy to Inhibit GVHD Biology of Blood and Marrow Transplantation. 25: S25-S26. DOI: 10.1016/J.Bbmt.2018.12.095  0.203
2021 Ramic M, Andrade NS, Rybin MJ, Esanov R, Wahlestedt C, Benatar M, Zeier Z. Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD. Brain Sciences. 11. PMID 34827542 DOI: 10.3390/brainsci11111543  0.203
2022 Khorkova O, Stahl J, Joji A, Volmar CH, Zeier Z, Wahlestedt C. Natural antisense transcripts as drug targets. Frontiers in Molecular Biosciences. 9: 978375. PMID 36250017 DOI: 10.3389/fmolb.2022.978375  0.201
1999 Wahlestedt C, Good L. Antisense oligonucleotides - the way forward. Current Opinion in Drug Discovery & Development. 2: 142-6. PMID 19649940  0.196
2013 Clarke J, Penas C, Pastori C, Komotar RJ, Bregy A, Shah AH, Wahlestedt C, Ayad NG. Epigenetic pathways and glioblastoma treatment. Epigenetics : Official Journal of the Dna Methylation Society. 8: 785-95. PMID 23807265 DOI: 10.4161/Epi.25440  0.196
1996 Weng G, Feinstein D, Reis D, Wahlestedt C. Neuropeptide Y receptor gene regulation in mouse adrenocortical Y-1 cells. Regulatory Peptides. 63: 53-6. PMID 8795089 DOI: 10.1016/0167-0115(96)00030-4  0.196
2012 Magistri M, Faghihi MA, St Laurent G, Wahlestedt C. Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts. Trends in Genetics : Tig. 28: 389-96. PMID 22541732 DOI: 10.1016/J.Tig.2012.03.013  0.195
2011 Modarresi F, Faghihi MA, Patel NS, Sahagan BG, Wahlestedt C, Lopez-Toledano MA. Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis. International Journal of Alzheimer's Disease. 2011: 929042. PMID 21785702 DOI: 10.4061/2011/929042  0.194
2013 Khorkova O, Hsiao J, Wahlestedt C. Oligonucleotides for upregulating gene expression. Pharmaceutical Patent Analyst. 2: 215-29. PMID 24237027 DOI: 10.4155/Ppa.13.4  0.192
2017 Esanov R, Cabrera GT, Andrade NS, Gendron TF, Brown RH, Benatar M, Wahlestedt C, Mueller C, Zeier Z. A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD. Molecular Neurodegeneration. 12: 46. PMID 28606110 DOI: 10.1186/S13024-017-0185-9  0.192
2014 Peschansky VJ, Wahlestedt C. Non-coding RNAs as direct and indirect modulators of epigenetic regulation. Epigenetics : Official Journal of the Dna Methylation Society. 9: 3-12. PMID 24739571 DOI: 10.4161/Epi.27473  0.191
2017 Khorkova O, Wahlestedt C. Oligonucleotide therapies for disorders of the nervous system. Nature Biotechnology. 35: 249-263. PMID 28244991 DOI: 10.1038/nbt.3784  0.19
1995 Fraser GL, Wahlestedt C. Section review: Biologicals & immunologicals: Applications of antisense technology to both basic and clinical Research Expert Opinion On Investigational Drugs. 4: 637-646. DOI: 10.1517/13543784.4.7.637  0.19
2012 Peschansky VJ, Liang Z, Wahlestedt C. RNAi joins the "Singles Club". Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2010-1. PMID 23131851 DOI: 10.1038/Mt.2012.218  0.188
2006 Wahlestedt C. Natural antisense and noncoding RNA transcripts as potential drug targets. Drug Discovery Today. 11: 503-8. PMID 16713901 DOI: 10.1016/J.Drudis.2006.04.013  0.188
2015 Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C. Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells. Frontiers in Genetics. 6: 263. PMID 26322075 DOI: 10.3389/Fgene.2015.00263  0.186
2016 Hsiao J, Yuan TY, Tsai MS, Lu CY, Lin YC, Lee ML, Lin SW, Chang FC, Liu Pimentel H, Olive C, Coito C, Shen G, Young M, Thorne T, Lawrence M, ... ... Wahlestedt C, et al. Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome Ebiomedicine. DOI: 10.1016/j.ebiom.2016.05.011  0.186
2023 Khorkova O, Stahl J, Joji A, Volmar CH, Zeier Z, Wahlestedt C. Long non-coding RNA-targeting therapeutics: discovery and development update. Expert Opinion On Drug Discovery. 1-19. PMID 37466388 DOI: 10.1080/17460441.2023.2236552  0.184
2005 Elmén J, Thonberg H, Ljungberg K, Frieden M, Westergaard M, Xu Y, Wahren B, Liang Z, Ørum H, Koch T, Wahlestedt C. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Research. 33: 439-47. PMID 15653644 DOI: 10.1093/Nar/Gki193  0.181
2023 Vilca SJ, Margetts AV, Fleites I, Wahlestedt C, Tuesta LM. Microglia contribute to methamphetamine reinforcement and reflect persistent transcriptional and morphological adaptations to the drug. Biorxiv : the Preprint Server For Biology. PMID 37961443 DOI: 10.1101/2023.10.19.563168  0.181
2008 Khalil AM, Wahlestedt C. Epigenetic mechanisms of gene regulation during mammalian spermatogenesis. Epigenetics : Official Journal of the Dna Methylation Society. 3: 21-8. PMID 18416029  0.181
2009 St Laurent G, Faghihi MA, Wahlestedt C. Non-coding RNA transcripts: sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease. Neuroscience Letters. 466: 81-8. PMID 19699259 DOI: 10.1016/J.Neulet.2009.08.032  0.178
2006 Larsson O, Perlman DM, Fan D, Reilly CS, Peterson M, Dahlgren C, Liang Z, Li S, Polunovsky VA, Wahlestedt C, Bitterman PB. Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure. Nucleic Acids Research. 34: 4375-86. PMID 16936314 DOI: 10.1093/Nar/Gkl558  0.175
2012 Pastori C, Wahlestedt C. Involvement of long noncoding RNAs in diseases affecting the central nervous system. Rna Biology. 9: 860-70. PMID 22699553 DOI: 10.4161/rna.20482  0.174
2008 Shan G, Li Y, Zhang J, Li W, Szulwach KE, Duan R, Faghihi MA, Khalil AM, Lu L, Paroo Z, Chan AW, Shi Z, Liu Q, Wahlestedt C, He C, et al. A small molecule enhances RNA interference and promotes microRNA processing. Nature Biotechnology. 26: 933-40. PMID 18641635 DOI: 10.1038/Nbt.1481  0.173
2020 Blokhin IO, Khorkova O, Saveanu RV, Wahlestedt C. Molecular mechanisms of psychiatric diseases. Neurobiology of Disease. 146: 105136. PMID 33080337 DOI: 10.1016/j.nbd.2020.105136  0.173
2008 Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, Kenny PJ, Wahlestedt C. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nature Medicine. 14: 723-30. PMID 18587408 DOI: 10.1038/Nm1784  0.173
2014 Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, Faghihi MA, Wahlestedt C, Troncoso JC, Pletnikova O, Perrone-Bizzozero N, et al. HuD regulates coding and noncoding RNA to induce APP→Aβ processing. Cell Reports. 7: 1401-9. PMID 24857657 DOI: 10.1016/J.Celrep.2014.04.050  0.173
2019 Timmons JA, Volmar CH, Crossland H, Phillips BE, Sood S, Janczura KJ, Törmäkangas T, Kujala UM, Kraus WE, Atherton PJ, Wahlestedt C. Longevity-related molecular pathways are subject to midlife "switch" in humans. Aging Cell. e12970. PMID 31168962 DOI: 10.1111/Acel.12970  0.172
2021 Khorkova O, Hsiao J, Wahlestedt C. Nucleic Acid-Based Therapeutics in Orphan Neurological Disorders: Recent Developments. Frontiers in Molecular Biosciences. 8: 643681. PMID 33996898 DOI: 10.3389/fmolb.2021.643681  0.172
2014 Pastori C, Peschansky VJ, Barbouth D, Mehta A, Silva JP, Wahlestedt C. Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. Human Genetics. 133: 59-67. PMID 24005575 DOI: 10.1007/S00439-013-1356-6  0.171
2005 Pang KC, Stephen S, Engström PG, Tajul-Arifin K, Chen W, Wahlestedt C, Lenhard B, Hayashizaki Y, Mattick JS. RNAdb--a comprehensive mammalian noncoding RNA database. Nucleic Acids Research. 33: D125-30. PMID 15608161 DOI: 10.1093/Nar/Gki089  0.171
2015 Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z. C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells. Experimental Neurology. PMID 26746986 DOI: 10.1016/J.Expneurol.2015.12.022  0.17
2015 Khorkova O, Hsiao J, Wahlestedt C. Basic biology and therapeutic implications of lncRNA Advanced Drug Delivery Reviews. 87: 15-24. DOI: 10.1016/j.addr.2015.05.012  0.169
2005 Chen M, Zhang L, Zhang HY, Xiong X, Wang B, Du Q, Lu B, Wahlestedt C, Liang Z. A universal plasmid library encoding all permutations of small interfering RNA. Proceedings of the National Academy of Sciences of the United States of America. 102: 2356-61. PMID 15695593 DOI: 10.1073/Pnas.0401549101  0.169
2016 Heilig M, Barbier E, Johnstone AL, Tapocik J, Meinhardt MW, Pfarr S, Wahlestedt CR, Sommer WH. Reprogramming of mPFC transcriptome and function in alcohol dependence. Genes, Brain, and Behavior. PMID 27657733 DOI: 10.1111/Gbb.12344  0.168
2023 McCartan R, Khorkova O, Volmar CH, Wahlestedt C. Nucleic acid-based therapeutics for the treatment of central nervous system disorders. Frontiers in Genetics. 14: 1250276. PMID 37662844 DOI: 10.3389/fgene.2023.1250276  0.167
2021 Van Booven D, Mengying Li, Sunil Rao J, Blokhin IO, Dayne Mayfield R, Barbier E, Heilig M, Wahlestedt C. Alcohol use disorder causes global changes in splicing in the human brain. Translational Psychiatry. 11: 2. PMID 33414398 DOI: 10.1038/s41398-020-01163-z  0.166
2000 Fraser GL, Holmgren J, Clarke PB, Wahlestedt C. Antisense inhibition of delta-opioid receptor gene function in vivo by peptide nucleic acids. Molecular Pharmacology. 57: 725-31. PMID 10727518  0.165
2005 Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, ... Wahlestedt C, et al. Antisense transcription in the mammalian transcriptome. Science (New York, N.Y.). 309: 1564-6. PMID 16141073 DOI: 10.1126/Science.1112009  0.165
2019 Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, Cabezas J, Lozano JJ, Van Booven D, Bell A, Cao S, Vernetti LA, Arab JP, Ventura-Cots M, Edmunds LR, ... Wahlestedt C, et al. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nature Communications. 10: 3126. PMID 31311938 DOI: 10.1038/S41467-019-11004-3  0.164
2020 Bagheri A, Razavipour SF, Wahlestedt C, Mowla SJ, Faghihi MA. A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons. Journal of Visualized Experiments : Jove. PMID 32831302 DOI: 10.3791/60955  0.163
2020 Wahlestedt C, Khorkova O. Direct Administration and Gene Modulation Using Antisense Oligonucleotides Within the CNS. Cellular and Molecular Neurobiology. PMID 32656646 DOI: 10.1007/S10571-020-00919-X  0.161
2007 Scheele C, Petrovic N, Faghihi MA, Lassmann T, Fredriksson K, Rooyackers O, Wahlestedt C, Good L, Timmons JA. The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. Bmc Genomics. 8: 74. PMID 17362513 DOI: 10.1186/1471-2164-8-74  0.161
2009 Faghihi MA, Wahlestedt C. Regulatory roles of natural antisense transcripts. Nature Reviews. Molecular Cell Biology. 10: 637-43. PMID 19638999 DOI: 10.1038/Nrm2738  0.161
2018 Wahlestedt C, Lohse I. PLX51107, a promising novel bromodomain and extra-terminal inhibitor in chronic lymphoid leukemia treatment Precision Cancer Medicine. 1: 14-14. DOI: 10.21037/pcm.2018.09.04  0.16
2013 Halley P, Khorkova O, Wahlestedt C. Natural antisense transcripts as therapeutic targets. Drug Discovery Today. Therapeutic Strategies. 10: e119-e125. PMID 25580147 DOI: 10.1016/j.ddstr.2013.03.001  0.158
2006 Frith MC, Wilming LG, Forrest A, Kawaji H, Tan SL, Wahlestedt C, Bajic VB, Kai C, Kawai J, Carninci P, Hayashizaki Y, Bailey TL, Huminiecki L. Pseudo-messenger RNA: phantoms of the transcriptome. Plos Genetics. 2: e23. PMID 16683022 DOI: 10.1371/Journal.Pgen.0020023  0.157
2023 Stokes T, Cen HH, Kapranov P, Gallagher IJ, Pitsillides AA, Volmar CH, Kraus WE, Johnson JD, Phillips SM, Wahlestedt C, Timmons JA. Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq. Advanced Genetics (Hoboken, N.J.). 4: 2200024. PMID 37288167 DOI: 10.1002/ggn2.202200024  0.157
2016 Esanov R, Andrade NS, Bennison S, Wahlestedt C, Zeier Z. The FMR1 promoter is selectively hydroxymethylated in primary neurons of Fragile X Syndrome patients. Human Molecular Genetics. PMID 27599747 DOI: 10.1093/hmg/ddw311  0.157
2006 Faghihi MA, Wahlestedt C. RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals. Genome Biology. 7: R38. PMID 16684369 DOI: 10.1186/Gb-2006-7-5-R38  0.155
2005 Chen M, Du Q, Zhang HY, Wahlestedt C, Liang Z. Vector-based siRNA delivery strategies for high-throughput screening of novel target genes. Journal of Rnai and Gene Silencing : An International Journal of Rna and Gene Targeting Research. 1: 5-11. PMID 19771198  0.155
2010 Silva JP, Wahlestedt C. Role of Sirtuin 1 in metabolic regulation. Drug Discovery Today. 15: 781-91. PMID 20621197 DOI: 10.1016/J.Drudis.2010.07.001  0.154
2023 Lalwani RC, Volmar CH, Wahlestedt C, Webster KA, Shehadeh LA. Contextualizing the Role of Osteopontin in the Inflammatory Responses of Alzheimer's Disease. Biomedicines. 11. PMID 38137453 DOI: 10.3390/biomedicines11123232  0.154
2014 Plotkin A, Volmar CH, Wahlestedt C, Ayad N, El-Ashry D. Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs. Breast Cancer Research and Treatment. 147: 249-63. PMID 25129342 DOI: 10.1007/S10549-014-3093-5  0.154
2015 Khorkova O, Hsiao J, Wahlestedt C. Basic biology and therapeutic implications of lncRNA. Advanced Drug Delivery Reviews. 87: 15-24. PMID 26024979 DOI: 10.1016/j.addr.2015.05.012  0.153
2018 Janczura KJ, Volmar CH, Wahlestedt C. Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue. Journal of Visualized Experiments : Jove. PMID 30582583 DOI: 10.3791/58648  0.153
2008 Dahlgren C, Zhang HY, Du Q, Grahn M, Norstedt G, Wahlestedt C, Liang Z. Analysis of siRNA specificity on targets with double-nucleotide mismatches. Nucleic Acids Research. 36: e53. PMID 18420656 DOI: 10.1093/Nar/Gkn190  0.153
2017 Wahlestedt C. Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 42: 374. PMID 27909334 DOI: 10.1038/npp.2016.203  0.151
1991 Heilig M, Edvinsson L, Wahlestedt C. Effects of intracerebroventricular D-myo-inositol-1,2,6-trisphosphate (PP56), a proposed neuropeptide Y (NPY) antagonist, on locomotor activity, food intake, central effects of NPY and NPY-receptor binding. European Journal of Pharmacology. 209: 27-32. PMID 1667639 DOI: 10.1016/0014-2999(91)90006-C  0.151
2019 Johnstone AL, Andrade NS, Barbier E, Khomtchouk BB, Rienas CA, Lowe K, Van Booven DJ, Domi E, Esanov R, Vilca S, Tapocik JD, Rodriguez K, Maryanski D, Keogh MC, Meinhardt MW, ... ... Wahlestedt C, et al. Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways. Addiction Biology. e12816. PMID 31373129 DOI: 10.1111/Adb.12816  0.151
2010 Lopez-Toledano MA, Ali Faghihi M, Patel NS, Wahlestedt C. Adult neurogenesis: a potential tool for early diagnosis in Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 20: 395-408. PMID 20164555 DOI: 10.3233/Jad-2010-1388  0.15
2004 Thonberg H, Schéele CC, Dahlgren C, Wahlestedt C. Characterization of RNA interference in rat PC12 cells: requirement of GERp95. Biochemical and Biophysical Research Communications. 318: 927-34. PMID 15147961 DOI: 10.1016/J.Bbrc.2004.04.119  0.149
2010 Faghihi MA, Zhang M, Huang J, Modarresi F, Van der Brug MP, Nalls MA, Cookson MR, St-Laurent G, Wahlestedt C. Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biology. 11: R56. PMID 20507594 DOI: 10.1186/Gb-2010-11-5-R56  0.148
2018 Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar CH, Josse AR, Slentz C, Wahlestedt C, Phillips SM, Phillips BE, Gallagher IJ, Kraus WE. A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease. Nucleic Acids Research. PMID 29986096 DOI: 10.1093/Nar/Gky570  0.148
2006 Dahlgren C, Wahlestedt C, Thonberg H. No induction of anti-viral responses in human cell lines HeLa and MCF-7 when transfecting with siRNA or siLNA. Biochemical and Biophysical Research Communications. 341: 1211-7. PMID 16476582 DOI: 10.1016/J.Bbrc.2006.01.085  0.148
2018 Tan SK, Pastori C, Penas C, Komotar RJ, Ivan ME, Wahlestedt C, Ayad NG. Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme. Molecular Cancer. 17: 74. PMID 29558959 DOI: 10.1186/S12943-018-0822-0  0.148
2005 Du Q, Thonberg H, Wang J, Wahlestedt C, Liang Z. A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Research. 33: 1671-7. PMID 15781493 DOI: 10.1093/Nar/Gki647  0.148
2014 Khorkova O, Myers AJ, Hsiao J, Wahlestedt C. Natural antisense transcripts. Human Molecular Genetics. 23: R54-63. PMID 24838284 DOI: 10.1093/Hmg/Ddu207  0.148
2008 Hong J, Wei N, Chalk A, Wang J, Song Y, Yi F, Qiao RP, Sonnhammer EL, Wahlestedt C, Liang Z, Du Q. Focusing on RISC assembly in mammalian cells. Biochemical and Biophysical Research Communications. 368: 703-8. PMID 18252196 DOI: 10.1016/J.Bbrc.2008.01.116  0.146
2002 Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, ... Wahlestedt C, et al. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 420: 563-73. PMID 12466851 DOI: 10.1038/Nature01266  0.144
2016 Laurent GS, Vyatkin Y, Antonets D, Ri M, Qi Y, Saik O, Shtokalo D, de Hoon MJ, Kawaji H, Itoh M, Lassmann T, Arner E, Forrest AR, Nicolas E, ... Wahlestedt C, et al. Functional annotation of the vlinc class of non-coding RNAs using systems biology approach. Nucleic Acids Research. PMID 27001520 DOI: 10.1093/Nar/Gkw162  0.144
2018 Cao H, Wahlestedt C, Kapranov P. Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls. Trends in Genetics : Tig. PMID 30017313 DOI: 10.1016/J.Tig.2018.06.002  0.143
2009 Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, ... Wahlestedt C, et al. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics. 41: 553-62. PMID 19377474 DOI: 10.1038/Ng.375  0.142
1993 Wahlestedt C, Pich EM, Koob GF, Yee F, Heilig M. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science (New York, N.Y.). 259: 528-31. PMID 8380941 DOI: 10.1126/Science.8380941  0.141
2019 Yan Y, Ma J, Wang D, Lin D, Pang X, Wang S, Zhao Y, Shi L, Xue H, Pan Y, Zhang J, Wahlestedt C, Giles FJ, Chen Y, Gleave ME, et al. The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer. Embo Molecular Medicine. e10659. PMID 31559706 DOI: 10.15252/Emmm.201910659  0.14
2000 Hoja MR, Wahlestedt C, Höög C. A visual intracellular classification strategy for uncharacterized human proteins. Experimental Cell Research. 259: 239-46. PMID 10942595 DOI: 10.1006/Excr.2000.4948  0.139
1993 Erlinge D, Edvinsson L, Brunkwall J, Yee F, Wahlestedt C. Human neuropeptide Y Y1 receptor antisense oligodeoxynucleotide specifically inhibits neuropeptide Y-evoked vasoconstriction. European Journal of Pharmacology. 240: 77-80. PMID 8405124 DOI: 10.1016/0014-2999(93)90548-V  0.139
2007 Timmons JA, Wennmalm K, Larsson O, Walden TB, Lassmann T, Petrovic N, Hamilton DL, Gimeno RE, Wahlestedt C, Baar K, Nedergaard J, Cannon B. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proceedings of the National Academy of Sciences of the United States of America. 104: 4401-6. PMID 17360536 DOI: 10.1073/Pnas.0610615104  0.139
2004 Larsson O, Scheele C, Liang Z, Moll J, Karlsson C, Wahlestedt C. Kinetics of senescence-associated changes of gene expression in an epithelial, temperature-sensitive SV40 large T antigen model. Cancer Research. 64: 482-9. PMID 14744760 DOI: 10.1158/0008-5472.Can-03-1872  0.139
2016 Magistri M, Velmeshev D, Makhmutova M, Patel P, Sartor GC, Volmar CH, Wahlestedt C, Faghihi MA. The BET-bromodomain inhibitor JQ1 reduces inflammation and tau phosphorylation at Ser396 in the brain of the 3xTg model of Alzheimer's disease. Current Alzheimer Research. PMID 27117003 DOI: 10.2174/1567205013666160427101832  0.138
2005 Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, ... Wahlestedt C, et al. The transcriptional landscape of the mammalian genome. Science (New York, N.Y.). 309: 1559-63. PMID 16141072 DOI: 10.1126/Science.1112014  0.138
2011 Clark MB, Amaral PP, Schlesinger FJ, Dinger ME, Taft RJ, Rinn JL, Ponting CP, Stadler PF, Morris KV, Morillon A, Rozowsky JS, Gerstein MB, Wahlestedt C, Hayashizaki Y, Carninci P, et al. The reality of pervasive transcription. Plos Biology. 9: e1000625; discussion. PMID 21765801 DOI: 10.1371/Journal.Pbio.1000625  0.137
2020 Volmar C, Dennison J, Ricciardi NR, Janczura KJ, Walker BR, Brown JM, Stahl J, Hayward MA, Brothers SP, Wahlestedt C. Benefits of a novel highly bioavailable resveratrol formulation, JOTROL, for Alzheimer’s disease Alzheimer's & Dementia. 16. DOI: 10.1002/alz.046267  0.136
2019 Khomtchouk BB, Koehler WC, Van Booven DJ, Wahlestedt C. Optimized functional annotation of ChIP-seq data F1000research. 8: 612. DOI: 10.12688/F1000Research.18966.1  0.136
2004 Du Q, Thonberg H, Zhang HY, Wahlestedt C, Liang Z. Validating siRNA using a reporter made from synthetic DNA oligonucleotides. Biochemical and Biophysical Research Communications. 325: 243-9. PMID 15522225 DOI: 10.1016/J.Bbrc.2004.09.222  0.136
1995 Weng G, Yee F, Michl P, Reis D, Wahlestedt C. Studies on neuropeptide Y receptors in a mouse adrenocortical cell line. Molecular Pharmacology. 48: 9-14. PMID 7623780  0.135
2015 Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C. Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells Frontiers in Genetics. 6. DOI: 10.3389/fgene.2015.00263  0.134
2000 Good L, Sandberg R, Larsson O, Nielsen PE, Wahlestedt C. Antisense PNA effects in Escherichia coli are limited by the outer-membrane LPS layer. Microbiology (Reading, England). 146: 2665-70. PMID 11021941 DOI: 10.1099/00221287-146-10-2665  0.134
2000 Vaz Gomes A, Wahlestedt C. Altered behaviour following RNA interference knockdown of a C. elegans G-protein coupled receptor by ingested double stranded RNA. European Journal of Pharmacology. 397: R3-5. PMID 10844141 DOI: 10.1016/S0014-2999(00)00251-X  0.134
1993 Jazin EE, Yoo H, Blomqvist AG, Yee F, Weng G, Walker MW, Salon J, Larhammar D, Wahlestedt C. A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells. Regulatory Peptides. 47: 247-58. PMID 8234909 DOI: 10.1016/0167-0115(93)90392-L  0.133
2023 Vilca S, Wahlestedt C, Izenwasser S, Gainetdinov RR, Pardo M. Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure. Biomolecules. 13. PMID 37509143 DOI: 10.3390/biom13071107  0.133
1993 Wahlestedt C, Reis DJ. Neuropeptide Y-related peptides and their receptors--are the receptors potential therapeutic drug targets? Annual Review of Pharmacology and Toxicology. 33: 309-52. PMID 8494343 DOI: 10.1146/annurev.pa.33.040193.001521  0.133
2017 Copsel S, Manov J, Lightbourn CO, Barreras H, Bader CS, Pfeiffer BJ, Shah D, Wolf D, Komanduri KV, Wahlestedt C, Levy RB. Epigenetic Regulation Together with Treg Expansion: A New Combinatorial Strategy for Application in Experimental Allogeneic HSCT Biology of Blood and Marrow Transplantation. 23: S363. DOI: 10.1016/J.Bbmt.2016.12.311  0.133
2016 Barbier E, Johnstone AL, Khomtchouk BB, Tapocik JD, Pitcairn C, Rehman F, Augier E, Borich A, Schank JR, Rienas CA, Van Booven DJ, Sun H, Nätt D, Wahlestedt C, Heilig M. Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2. Molecular Psychiatry. PMID 27573876 DOI: 10.1038/Mp.2016.131  0.133
2003 Isacson R, Kull B, Salmi P, Wahlestedt C. Lack of efficacy of 'naked' small interfering RNA applied directly to rat brain. Acta Physiologica Scandinavica. 179: 173-7. PMID 14510781 DOI: 10.1046/J.1365-201X.2003.01188.X  0.132
2021 Modarresi F, Pedram Fatemi R, Razavipour SF, Ricciardi N, Makhmutova M, Khoury N, Magistri M, Volmar CH, Wahlestedt C, Faghihi MA. A novel knockout mouse model of the noncoding antisense () gene displays increased endogenous Bdnf protein and improved memory function following exercise. Heliyon. 7: e07570. PMID 34377851 DOI: 10.1016/j.heliyon.2021.e07570  0.132
2018 Volmar C, Salah-Uddin H, Janczura KJ, Halley P, Lambert G, Wodrich A, Manoah S, Patel NH, Sartor GC, Mehta N, Miles NT, Desse S, Dorcius D, Cameron MD, Brothers SP, Wahlestedt C, et al. 112. Multipronged HDAC Strategy for Alzheimer’s Disease Biological Psychiatry. 83: S46. DOI: 10.1016/J.Biopsych.2018.02.130  0.131
2012 Wahlestedt CR. Abstract IA21: Long noncoding RNAs as drug targets Cancer Research. 72: IA21-IA21. DOI: 10.1158/1538-7445.NONRNA12-IA21  0.13
2017 Barbier E, Johnstone A, Khomtchouk B, Tapocik J, Pitcairn C, Rehman F, Augier E, Borich A, Schank J, Rienas C, Van Booven D, Sun H, Nätt D, Wahlestedt C, Heilig M. Epigenetic enzymes as a novel class of targets for disease-modifying pharmacotherapies in alcohol addiction Alcohol. 60: 209. DOI: 10.1016/J.Alcohol.2017.02.211  0.13
1992 Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlestedt C. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type Journal of Biological Chemistry. 267: 10935-10938. PMID 1317848  0.13
1996 Sun XY, Zhao XH, Erlinge D, Edvinsson L, Fallgren B, Wahlestedt C, Hedner T. Effects of phosphorothioated neuropeptide Y Y1-receptor antisense oligodeoxynucleotide in conscious rats and in human vessels. British Journal of Pharmacology. 118: 131-6. PMID 8733585  0.129
2004 Xu Y, Linde A, Larsson O, Thormeyer D, Elmen J, Wahlestedt C, Liang Z. Functional comparison of single- and double-stranded siRNAs in mammalian cells. Biochemical and Biophysical Research Communications. 316: 680-7. PMID 15033453 DOI: 10.1016/J.Bbrc.2004.02.100  0.128
2022 Kurani H, Razavipour SF, Harikumar KB, Dunworth M, Ewald AJ, Nasir A, Pearson G, van Booven D, Zhou Z, Azzam D, Wahlestedt C, Slingerland J. DOT1L is a novel cancer stem cell target for triple negative breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 35135840 DOI: 10.1158/1078-0432.CCR-21-1299  0.128
2004 Thonberg H, Dahlgren C, Wahlestedt C. Antisense-induced Fas mRNA degradation produces site-specific stable 3'-mRNA fragment by exonuclease cleavage at the complementary sequence. Oligonucleotides. 14: 221-6. PMID 15625917 DOI: 10.1089/oli.2004.14.221  0.127
2006 Engström PG, Suzuki H, Ninomiya N, Akalin A, Sessa L, Lavorgna G, Brozzi A, Luzi L, Tan SL, Yang L, Kunarso G, Ng EL, Batalov S, Wahlestedt C, Kai C, et al. Complex Loci in human and mouse genomes. Plos Genetics. 2: e47. PMID 16683030 DOI: 10.1371/Journal.Pgen.0020047  0.127
2016 Hossein-Nezhad A, Fatemi RP, Ahmad R, Peskind E, Zabeitian C, Hu SC, Shi M, Wahlestedt C, Zhang J, Faghihi MA. Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Diseases. Journal of Parkinson's Disease. PMID 26889637 DOI: 10.3233/Jpd-150737  0.126
2010 Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C, Vollaard NB, Nielsen S, Akerström T, MacDougald OA, Jansson E, Greenhaff PL, Tarnopolsky MA, ... Wahlestedt C, et al. Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. Journal of Applied Physiology (Bethesda, Md. : 1985). 108: 1487-96. PMID 20133430 DOI: 10.1152/Japplphysiol.01295.2009  0.126
1994 Standifer KM, Chien CC, Wahlestedt C, Brown GP, Pasternak GW. Selective loss of delta opioid analgesia and binding by antisense oligodeoxynucleotides to a delta opioid receptor. Neuron. 12: 805-10. PMID 8161452 DOI: 10.1016/0896-6273(94)90333-6  0.125
2004 Chalk AM, Wahlestedt C, Sonnhammer EL. Improved and automated prediction of effective siRNA. Biochemical and Biophysical Research Communications. 319: 264-74. PMID 15158471 DOI: 10.1016/J.Bbrc.2004.04.181  0.125
1990 Wahlestedt C, Grundemar L, HÃ¥kanson R, Heilig M, Shen GH, Zukowska-Grojec Z, Reis DJ. Neuropeptide Y receptor subtypes, Y1 and Y2. Annals of the New York Academy of Sciences. 611: 7-26. PMID 2174225 DOI: 10.1111/J.1749-6632.1990.Tb48918.X  0.125
1988 Heilig M, Wahlestedt C, Widerlöv E. Neuropeptide Y (NPY)-induced suppression of activity in the rat: evidence for NPY receptor heterogeneity and for interaction with alpha-adrenoceptors. European Journal of Pharmacology. 157: 205-13. PMID 2852114 DOI: 10.1016/0014-2999(88)90384-6  0.124
2015 Volmar CH, Wahlestedt C. Histone deacetylases (HDACs) and brain function Neuroepigenetics. 1: 20-27. DOI: 1016/j.nepig.2014.10.002  0.124
2015 Volmar C, Wahlestedt C. Histone deacetylases (HDACs) and brain function Neuroepigenetics. 1: 20-27. DOI: 10.1016/j.nepig.2014.10.002  0.124
2005 Mottagui-Tabar S, Faghihi MA, Mizuno Y, Engström PG, Lenhard B, Wasserman WW, Wahlestedt C. Identification of functional SNPs in the 5-prime flanking sequences of human genes. Bmc Genomics. 6: 18. PMID 15717931 DOI: 10.1186/1471-2164-6-18  0.123
2006 Carninci P, Sandelin A, Lenhard B, Katayama S, Shimokawa K, Ponjavic J, Semple CA, Taylor MS, Engström PG, Frith MC, Forrest AR, Alkema WB, Tan SL, Plessy C, Kodzius R, ... ... Wahlestedt C, et al. Genome-wide analysis of mammalian promoter architecture and evolution. Nature Genetics. 38: 626-35. PMID 16645617 DOI: 10.1038/Ng1789  0.122
2015 St Laurent G, Wahlestedt C, Kapranov P. The Landscape of long noncoding RNA classification. Trends in Genetics : Tig. 31: 239-51. PMID 25869999 DOI: 10.1016/J.Tig.2015.03.007  0.122
2000 Fraser GL, Pradhan AA, Clarke PB, Wahlestedt C. Supraspinal antinociceptive response to [D-Pen(2,5)]-enkephalin (DPDPE) is pharmacologically distinct from that to other delta-agonists in the rat. The Journal of Pharmacology and Experimental Therapeutics. 295: 1135-41. PMID 11082450  0.122
2010 Gallagher IJ, Scheele C, Keller P, Nielsen AR, Remenyi J, Fischer CP, Roder K, Babraj J, Wahlestedt C, Hutvagner G, Pedersen BK, Timmons JA. Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Medicine. 2: 9. PMID 20353613 DOI: 10.1186/Gm130  0.122
2005 Timmons JA, Larsson O, Jansson E, Fischer H, Gustafsson T, Greenhaff PL, Ridden J, Rachman J, Peyrard-Janvid M, Wahlestedt C, Sundberg CJ. Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 750-60. PMID 15857889 DOI: 10.1096/Fj.04-1980Com  0.122
1993 Larhammar D, Blomqvist AG, Wahlestedt C. The receptor revolution--multiplicity of G-protein-coupled receptors. Drug Design and Discovery. 9: 179-88. PMID 8400001  0.121
2006 Volmar C, Janczura KJ, Lambert G, Salah-Uddin H, Halley P, Sartor GC, Brothers SP, Wahlestedt C. P4-220: MULTIFACTORIAL EPIGENETIC STRATEGY FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1527-P1527. DOI: 10.1016/J.Jalz.2018.07.041  0.12
2020 Stokes T, Timmons JA, Crossland H, Tripp TR, Murphy K, McGlory C, Mitchell CJ, Oikawa SY, Morton RW, Phillips BE, Baker SK, Atherton PJ, Wahlestedt C, Phillips SM. Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States. Cell Reports. 32: 107980. PMID 32755574 DOI: 10.1016/J.Celrep.2020.107980  0.119
2018 Heilig M, Wahlestedt C, Barbier E, Johnstone A. 10. Epigenetic Enzymes as Novel Therapeutic Targets in Alcohol Addiction Biological Psychiatry. 83: S4. DOI: 10.1016/J.Biopsych.2018.02.027  0.119
2010 Hollander JA, Im HI, Amelio AL, Kocerha J, Bali P, Lu Q, Willoughby D, Wahlestedt C, Conkright MD, Kenny PJ. Striatal microRNA controls cocaine intake through CREB signalling. Nature. 466: 197-202. PMID 20613834 DOI: 10.1038/Nature09202  0.119
2009 Kocerha J, Kauppinen S, Wahlestedt C. microRNAs in CNS disorders. Neuromolecular Medicine. 11: 162-72. PMID 19536656 DOI: 10.1007/S12017-009-8066-1  0.119
2004 Faghihi MA, Mottagui-Tabar S, Wahlestedt C. Genetics of neurological disorders. Expert Review of Molecular Diagnostics. 4: 317-32. PMID 15137899 DOI: 10.1586/14737159.4.3.317  0.119
1989 Wahlestedt C, Ekman R, Widerlöv E. Neuropeptide Y (NPY) and the central nervous system: distribution effects and possible relationship to neurological and psychiatric disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 13: 31-54. PMID 2664885 DOI: 10.1016/0278-5846(89)90003-1  0.118
2004 Kemmer D, Faxén M, Hodges E, Lim J, Herzog E, Ljungström E, Lundmark A, Olsen MK, Podowski R, Sonnhammer EL, Nilsson P, Reimers M, Lenhard B, Roberds SL, Wahlestedt C, et al. Exploring the foundation of genomics: a northern blot reference set for the comparative analysis of transcript profiling technologies. Comparative and Functional Genomics. 5: 584-95. PMID 18629180 DOI: 10.1002/Cfg.443  0.117
2015 Gidlöf O, Sathanoori R, Magistri M, Faghihi MA, Wahlestedt C, Olde B, Erlinge D. Extracellular Uridine Triphosphate and Adenosine Triphosphate Attenuate Endothelial Inflammation through miR-22-Mediated ICAM-1 Inhibition. Journal of Vascular Research. 52: 71-80. PMID 26088024 DOI: 10.1159/000431367  0.117
1992 Wahlestedt C, Regunathan S, Reis DJ. Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY. Life Sciences. 50: PL7-12. PMID 1310131 DOI: 10.1016/0024-3205(92)90342-M  0.117
2005 Wennmalm K, Wahlestedt C, Larsson O. The expression signature of in vitro senescence resembles mouse but not human aging. Genome Biology. 6: R109. PMID 16420669 DOI: 10.1186/Gb-2005-6-13-R109  0.116
2008 Kemmer D, Podowski RM, Yusuf D, Brumm J, Cheung W, Wahlestedt C, Lenhard B, Wasserman WW. Gene characterization index: assessing the depth of gene annotation. Plos One. 3: e1440. PMID 18213364 DOI: 10.1371/Journal.Pone.0001440  0.116
2005 McCarthy S, Mottagui-Tabar S, Mizuno Y, Sennblad B, Hoffstedt J, Arner P, Wahlestedt C, Andersson B. Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin. Human Genetics. 117: 545-57. PMID 16021472 DOI: 10.1007/S00439-005-1328-6  0.116
2007 Scheele C, Nielsen AR, Walden TB, Sewell DA, Fischer CP, Brogan RJ, Petrovic N, Larsson O, Tesch PA, Wennmalm K, Hutchinson DS, Cannon B, Wahlestedt C, Pedersen BK, Timmons JA. Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration? Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3653-65. PMID 17567565 DOI: 10.1096/Fj.07-8520Com  0.116
2012 St Laurent G, Shtokalo D, Tackett MR, Yang Z, Eremina T, Wahlestedt C, Urcuqui-Inchima S, Seilheimer B, McCaffrey TA, Kapranov P. Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells. Bmc Genomics. 13: 504. PMID 23006825 DOI: 10.1186/1471-2164-13-504  0.115
2016 Gidlöf O, Johnstone AL, Bader K, Khomtchouk BB, O'Reilly JJ, Celik S, Van Booven DJ, Wahlestedt C, Metzler B, Erlinge D. Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation. Journal of the American Heart Association. 5. PMID 28007739 DOI: 10.1161/Jaha.116.004076  0.114
1992 Sundelin JB, Provvedini DM, Wahlestedt CR, Laurell H, Pohl JS, Peterson PA. Molecular cloning of the murine substance K and substance P receptor genes. European Journal of Biochemistry / Febs. 203: 625-31. PMID 1370937  0.114
2021 Dennison JL, Ricciardi NR, Lohse I, Volmar CH, Wahlestedt C. Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical Research. Journal of Alzheimer's Disease : Jad. PMID 33459720 DOI: 10.3233/JAD-201014  0.114
2003 Ahlqvist J, Isacson R, Wahlestedt C, Salmi P. Anti-cataleptic effects of clozapine, but not olanzapine and quetiapine, on SCH 23390- or raclopride-induced catalepsy in rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 13: 177-82. PMID 12729943 DOI: 10.1016/S0924-977X(03)00004-X  0.113
1994 Adner M, Erlinge D, Salford LG, Yee F, Wahlestedt C, Edvinsson L. Human endothelin ETA receptor antisense oligodeoxynucleotides inhibit endothelin-1 evoked vasoconstriction. European Journal of Pharmacology. 261: 281-4. PMID 7813549 DOI: 10.1016/0014-2999(94)90118-X  0.112
2005 Larsson O, Wahlestedt C, Timmons JA. Considerations when using the significance analysis of microarrays (SAM) algorithm. Bmc Bioinformatics. 6: 129. PMID 15921534 DOI: 10.1186/1471-2105-6-129  0.112
2015 Pastori C, Kapranov P, Penas C, Peschansky V, Volmar CH, Sarkaria JN, Bregy A, Komotar R, Laurent GS, Ayad NG, Wahlestedt C, Roberts TC. The bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation Proceedings of the National Academy of Sciences of the United States of America. 112: 8326-8331. DOI: 10.1073/pnas.1424220112  0.112
1994 Akabayashi A, Watanabe Y, Wahlestedt C, McEwen BS, Paez X, Leibowitz SF. Hypothalamic neuropeptide Y, its gene expression and receptor activity: relation to circulating corticosterone in adrenalectomized rats. Brain Research. 665: 201-12. PMID 7895055 DOI: 10.1016/0006-8993(94)91339-0  0.112
1989 Wahlestedt C, Ekman R, Heilig M, Widerlöv E. Effects of psychoactive drugs on delta sleep-inducing peptide concentrations in rat brain. European Journal of Pharmacology. 159: 285-9. PMID 2522052 DOI: 10.1016/0014-2999(89)90159-3  0.112
1991 Aicher SA, Springston M, Berger SB, Reis DJ, Wahlestedt C. Receptor-selective analogs demonstrate NPY/PYY receptor heterogeneity in rat brain. Neuroscience Letters. 130: 32-6. PMID 1660972 DOI: 10.1016/0304-3940(91)90220-N  0.112
1994 Nystedt S, Emilsson K, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proceedings of the National Academy of Sciences of the United States of America. 91: 9208-12. PMID 7937743 DOI: 10.1073/Pnas.91.20.9208  0.11
2017 Aziz AMA, Brothers S, Sartor G, Heilig M, Wahlestedt C, Thorsell A. The Nociceptin/Orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: Validation in rat models Alcohol. 60: 233. DOI: 10.1016/J.ALCOHOL.2017.02.313  0.11
2004 Isacson R, Kull B, Wahlestedt C, Salmi P. A 68930 and dihydrexidine inhibit locomotor activity and d-amphetamine-induced hyperactivity in rats: a role of inhibitory dopamine D(1/5) receptors in the prefrontal cortex? Neuroscience. 124: 33-42. PMID 14960337 DOI: 10.1016/j.neuroscience.2003.11.016  0.11
2004 Wahlestedt C, Brookes AJ, Mottagui-Tabar S. Lower rate of genomic variation identified in the trans-membrane domain of monoamine sub-class of Human G-Protein Coupled Receptors: the Human GPCR-DB Database. Bmc Genomics. 5: 91. PMID 15579207 DOI: 10.1186/1471-2164-5-91  0.11
2000 Wahlestedt C, Salmi P, Good L, Kela J, Johnsson T, Hökfelt T, Broberger C, Porreca F, Lai J, Ren K, Ossipov M, Koshkin A, Jakobsen N, Skouv J, Oerum H, et al. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proceedings of the National Academy of Sciences of the United States of America. 97: 5633-8. PMID 10805816 DOI: 10.1073/pnas.97.10.5633  0.11
2009 Kocerha J, Faghihi MA, Lopez-Toledano MA, Huang J, Ramsey AJ, Caron MG, Sales N, Willoughby D, Elmen J, Hansen HF, Orum H, Kauppinen S, Kenny PJ, Wahlestedt C. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 106: 3507-12. PMID 19196972 DOI: 10.1073/Pnas.0805854106  0.11
2001 Kashuba VI, Kvasha SM, Protopopov AI, Gizatullin RZ, Rynditch AV, Wahlestedt C, Wasserman WW, Zabarovsky ER. Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. Gene. 268: 115-22. PMID 11368907 DOI: 10.1016/S0378-1119(01)00423-1  0.109
1991 Shen GH, Grundemar L, Zukowska-Grojec Z, HÃ¥kanson R, Wahlestedt C. C-terminal neuropeptide Y fragments are mast cell-dependent vasodepressor agents. European Journal of Pharmacology. 204: 249-56. PMID 1723049 DOI: 10.1016/0014-2999(91)90849-L  0.109
2013 Ozomaro U, Wahlestedt C, Nemeroff CB. Personalized medicine in psychiatry: problems and promises. Bmc Medicine. 11: 132. PMID 23680237 DOI: 10.1186/1741-7015-11-132  0.108
1993 Franklin SO, Elliott K, Zhu YS, Wahlestedt C, Inturrisi CE. Quantitation of NMDA receptor (NMDAR1) mRNA levels in the adult and developing rat CNS. Brain Research. Molecular Brain Research. 19: 93-100. PMID 7689684 DOI: 10.1016/0169-328X(93)90153-G  0.108
2003 Thormeyer D, Ammerpohl O, Larsson O, Xu Y, Asinger A, Wahlestedt C, Liang Z. Characterization of lacZ complementation deletions using membrane receptor dimerization. Biotechniques. 34: 346-50, 352-5. PMID 12613257 DOI: 10.2144/03342Rr05  0.108
2018 Brothers S, Volmar C, Bodamer O, Hayward M, Wahlestedt C. Novel small molecule therapy development for MPS I Molecular Genetics and Metabolism. 123: S26. DOI: 10.1016/J.Ymgme.2017.12.043  0.106
2018 Zhu W, Wang H, Wei J, Sartor GC, Bao MM, Pierce CT, Wahlestedt CR, Dykxhoorn DM, Dong C. Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway. Hypertension (Dallas, Tex. : 1979). PMID 29483230 DOI: 10.1161/Hypertensionaha.117.10213  0.106
2000 Kashuba V, Protopopov A, Podowski R, Gizatullin R, Li J, Klein G, Wahlestedt C, Zabarovsky E. Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A). European Journal of Human Genetics : Ejhg. 8: 407-13. PMID 10878660 DOI: 10.1038/Sj.Ejhg.5200474  0.106
1993 Zukowska-Grojec Z, Pruszczyk P, Colton C, Yao J, Shen GH, Myers AK, Wahlestedt C. Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells. Peptides. 14: 263-8. PMID 8483806 DOI: 10.1016/0196-9781(93)90040-N  0.106
2000 Salmi P, Sproat BS, Ludwig J, Hale R, Avery N, Kela J, Wahlestedt C. Dopamine D(2) receptor ribozyme inhibits quinpirole-induced stereotypy in rats. European Journal of Pharmacology. 388: R1-2. PMID 10657555 DOI: 10.1016/S0014-2999(99)00866-3  0.105
2019 Cao H, Salazar-García L, Gao F, Wahlestedt T, Wu CL, Han X, Cai Y, Xu D, Wang F, Tang L, Ricciardi N, Cai D, Wang H, Chin MPS, Timmons JA, ... Wahlestedt C, et al. Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells. Nature Communications. 10: 5799. PMID 31862872 DOI: 10.1038/S41467-019-13602-7  0.104
2003 Kela J, Salmi P, Rimondini-Giorgini R, Heilig M, Wahlestedt C. Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties. Regulatory Peptides. 114: 109-14. PMID 12832098 DOI: 10.1016/S0167-0115(03)00114-9  0.102
2002 Kashuba VI, Protopopov AI, Kvasha SM, Gizatullin RZ, Wahlestedt C, Kisselev LL, Klein G, Zabarovsky ER. hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein. Gene. 283: 209-17. PMID 11867227 DOI: 10.1016/S0378-1119(01)00856-3  0.102
1998 Ahmad S, O'Donnell D, Payza K, Ducharme J, Ménard D, Brown W, Schmidt R, Wahlestedt C, Shen SH, Walker P. Cloning and evaluation of the role of rat GALR-2, a novel subtype of galanin receptor, in the control of pain perception. Annals of the New York Academy of Sciences. 863: 108-19. PMID 9928164 DOI: 10.1111/j.1749-6632.1998.tb10688.x  0.102
2003 Lenhard B, Wahlestedt C, Wasserman WW. GeneLynx mouse: integrated portal to the mouse genome. Genome Research. 13: 1501-4. PMID 12819149 DOI: 10.1101/Gr.951403  0.102
2020 Andrade NS, Ramic M, Esanov R, Liu W, Rybin MJ, Gaidosh G, Abdallah A, Del'Olio S, Huff TC, Chee NT, Anatha S, Gendron TF, Wahlestedt C, Zhang Y, Benatar M, et al. Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD. Molecular Neurodegeneration. 15: 13. PMID 32093728 DOI: 10.1186/S13024-020-00365-9  0.101
1987 Edvinsson L, Håkanson R, Wahlestedt C, Uddman R. Effects of neuropeptide Y on the cardiovascular system Trends in Pharmacological Sciences. 8: 231-235. DOI: 10.1016/0165-6147(87)90069-1  0.101
2016 Silva JP, Lambert G, van Booven D, Wahlestedt C. Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring. Genome Medicine. 8: 93. PMID 27609221 DOI: 10.1186/s13073-016-0348-2  0.101
2020 Blokhin I, Van Booven D, Mayfield D, Argemi J, Bataller R, Barbier E, Heilig M, Wahlestedt C. Genome-Wide Effects of Alcohol Use Disorder on Long Non-Coding RNAs and Splicing in Brain and Liver Biological Psychiatry. 87: S178-S179. DOI: 10.1016/J.Biopsych.2020.02.469  0.101
2020 Rybin MJ, Ramic M, Ricciardi NR, Kapranov P, Wahlestedt C, Zeier Z. Emerging Technologies for Genome-Wide Profiling of DNA Breakage. Frontiers in Genetics. 11: 610386. PMID 33584810 DOI: 10.3389/fgene.2020.610386  0.1
2001 Sollerbrant K, Elmén J, Wahlestedt C, Acker J, Leblois-Prehaud H, Latta-Mahieu M, Yeh P, Perricaudet M. A novel method using baculovirus-mediated gene transfer for production of recombinant adeno-associated virus vectors. The Journal of General Virology. 82: 2051-60. PMID 11514714 DOI: 10.1099/0022-1317-82-9-2051  0.1
2010 Miller BH, Wahlestedt C. MicroRNA dysregulation in psychiatric disease. Brain Research. 1338: 89-99. PMID 20303342 DOI: 10.1016/j.brainres.2010.03.035  0.1
1999 O'Donnell D, Ahmad S, Wahlestedt C, Walker P. Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: distinct distribution from GALR1. The Journal of Comparative Neurology. 409: 469-81. PMID 10379831 DOI: 10.1002/(Sici)1096-9861(19990705)409:3<469::Aid-Cne10>3.0.Co;2-Q  0.1
2008 Franks PW, Scheele C, Loos RJ, Nielsen AR, Finucane FM, Wahlestedt C, Pedersen BK, Wareham NJ, Timmons JA. Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3135-45. PMID 18495756 DOI: 10.1096/Fj.08-107086  0.1
2003 Josephson A, Trifunovski A, Schéele C, Widenfalk J, Wahlestedt C, Brené S, Olson L, Spenger C. Activity-induced and developmental downregulation of the Nogo receptor. Cell and Tissue Research. 311: 333-42. PMID 12658441 DOI: 10.1007/s00441-002-0695-8  0.099
1991 Wahlestedt C. Strategies to detect heterologously expressed tachykinin receptors in Xenopus Oocytes. Annals of the New York Academy of Sciences. 632: 116-22. PMID 1719860  0.099
1992 Grundemar L, Jonas SE, Mörner N, Högestätt ED, Wahlestedt C, HÃ¥kanson R. Characterization of vascular neuropeptide Y receptors. British Journal of Pharmacology. 105: 45-50. PMID 1317737 DOI: 10.1111/J.1476-5381.1992.Tb14208.X  0.099
1996 Valiquette M, Vu HK, Yue SY, Wahlestedt C, Walker P. Involvement of Trp-284, Val-296, and Val-297 of the human delta-opioid receptor in binding of delta-selective ligands. The Journal of Biological Chemistry. 271: 18789-96. PMID 8702536 DOI: 10.1074/jbc.271.31.18789  0.099
1999 Eriksson A, Wahlestedt C, Nordqvist K. Isolation of sex-specific cDNAs from fetal mouse brain using mRNA differential display and representational difference analysis. Brain Research. Molecular Brain Research. 74: 91-7. PMID 10640679 DOI: 10.1016/S0169-328X(99)00265-X  0.098
2003 Xu Y, Zhang HY, Thormeyer D, Larsson O, Du Q, Elmén J, Wahlestedt C, Liang Z. Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the luciferase mRNAs. Biochemical and Biophysical Research Communications. 306: 712-7. PMID 12810077 DOI: 10.1016/S0006-291X(03)01024-6  0.097
1982 Ekström J, Wahlestedt C. Supersensitivity to substance P and physalaemin in rat salivary glands after denervation or decentralization. Acta Physiologica Scandinavica. 115: 437-46. PMID 6184951 DOI: 10.1111/J.1748-1716.1982.Tb07102.X  0.096
2002 Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proceedings of the National Academy of Sciences of the United States of America. 99: 2344-9. PMID 11782534 DOI: 10.1073/Pnas.022438099  0.096
2006 Fredman D, Sawyer SL, Strömqvist L, Mottagui-Tabar S, Kidd KK, Wahlestedt C, Chanock SJ, Brookes AJ. Nonsynonymous SNPs: validation characteristics, derived allele frequency patterns, and suggestive evidence for natural selection. Human Mutation. 27: 173-86. PMID 16429399 DOI: 10.1002/Humu.20289  0.096
2004 Heilig M, Zachrisson O, Thorsell A, Ehnvall A, Mottagui-Tabar S, Sjögren M, Asberg M, Ekman R, Wahlestedt C, Agren H. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. Journal of Psychiatric Research. 38: 113-21. PMID 14757324 DOI: 10.1016/S0022-3956(03)00101-8  0.095
1993 Grundemar L, Wahlestedt C, Wang ZY. Neuropeptide Y suppresses the neurogenic inflammatory response in the rabbit eye; mode of action. Regulatory Peptides. 43: 57-64. PMID 8381238 DOI: 10.1016/0167-0115(93)90407-Y  0.095
2005 Ding B, Kull B, Liu Z, Mottagui-Tabar S, Thonberg H, Gu HF, Brookes AJ, Grundemar L, Karlsson C, Hamsten A, Arner P, Ostenson CG, Efendic S, Monné M, von Heijne G, ... ... Wahlestedt C, et al. Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function. Regulatory Peptides. 127: 45-53. PMID 15680469 DOI: 10.1016/J.Regpep.2004.10.011  0.095
1988 Cox HM, Cuthbert AW, HÃ¥kanson R, Wahlestedt C. The effect of neuropeptide Y and peptide YY on electrogenic ion transport in rat intestinal epithelia. The Journal of Physiology. 398: 65-80. PMID 3392683 DOI: 10.1113/Jphysiol.1988.Sp017029  0.095
1994 Akabayashi A, Wahlestedt C, Alexander JT, Leibowitz SF. Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion. Brain Research. Molecular Brain Research. 21: 55-61. PMID 8164522 DOI: 10.1016/0169-328X(94)90377-8  0.095
2012 Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Edbauer D, Kleiman RJ, Wahlestedt C. MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. Proceedings of the National Academy of Sciences of the United States of America. 109: 3125-30. PMID 22315408 DOI: 10.1073/Pnas.1113793109  0.093
1995 Erlinge D, You J, Wahlestedt C, Edvinsson L. Characterisation of an ATP receptor mediating mitogenesis in vascular smooth muscle cells. European Journal of Pharmacology. 289: 135-49. PMID 7781705 DOI: 10.1016/0922-4106(95)90178-7  0.093
1997 Emilsson K, Wahlestedt C, Sun MK, Nystedt S, Owman C, Sundelin J. Vascular effects of proteinase-activated receptor 2 agonist peptide. Journal of Vascular Research. 34: 267-72. PMID 9256086 DOI: 10.1159/000159233  0.093
1986 Wahlestedt C, HÃ¥kanson R. Effects of neuropeptide Y (NPY) at the sympathetic neuroeffector junction. Can pre- and postjunctional receptors be distinguished? Medical Biology. 64: 85-8. PMID 3018392  0.093
1993 Erlinge D, Yoo H, Edvinsson L, Reis DJ, Wahlestedt C. Mitogenic effects of ATP on vascular smooth muscle cells vs. other growth factors and sympathetic cotransmitters. The American Journal of Physiology. 265: H1089-97. PMID 7694483 DOI: 10.1152/Ajpheart.1993.265.4.H1089  0.092
2016 Khomtchouk BB, Hennessy JR, Wahlestedt C. MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps. Bmc Bioinformatics. 17: 390. PMID 27659774 DOI: 10.1186/S12859-016-1260-X  0.092
1988 Widerlöv E, Lindström LH, Wahlestedt C, Ekman R. Neuropeptide Y and peptide YY as possible cerebrospinal fluid markers for major depression and schizophrenia, respectively. Journal of Psychiatric Research. 22: 69-79. PMID 3397912 DOI: 10.1016/0022-3956(88)90030-1  0.091
1988 Widerlöv E, Heilig M, Ekman R, Wahlestedt C. Possible relationship between neuropeptide Y (NPY) and major depression – evidence from human and animal studies Nordisk Psykiatrisk Tidsskrift. 42: 131-137. DOI: 10.3109/08039488809103218  0.091
1988 Heilig M, Wahlestedt C, Ekman R, Widerlöv E. Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain. European Journal of Pharmacology. 147: 465-7. PMID 2967771 DOI: 10.1016/0014-2999(88)90182-3  0.091
2004 Mottagui-Tabar S, McCarthy S, Reinemund J, Andersson B, Wahlestedt C, Heilig M. Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors. Alcohol and Alcoholism (Oxford, Oxfordshire). 39: 380-5. PMID 15304380 DOI: 10.1093/Alcalc/Agh086  0.09
1990 Wahlestedt C, Blendy JA, Kellar KJ, Heilig M, Widerlöv E, Ekman R. Electroconvulsive shocks increase the concentration of neocortical and hippocampal neuropeptide Y (NPY)-like immunoreactivity in the rat. Brain Research. 507: 65-8. PMID 2302581 DOI: 10.1016/0006-8993(90)90523-E  0.09
2005 Mottagui-Tabar S, Prince JA, Wahlestedt C, Zhu G, Goldman D, Heilig M. A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. Alcoholism, Clinical and Experimental Research. 29: 702-7. PMID 15897713 DOI: 10.1097/01.Alc.0000164365.04961.B1  0.09
1996 Sun X, You J, Hedner T, Erlinge D, Fellström B, Yoo H, Wahlestedt C, Edvinsson L. alpha-Trinositol: a functional (non-receptor) neuropeptide Y antagonist in vasculature. The Journal of Pharmacy and Pharmacology. 48: 77-84. PMID 8722501 DOI: 10.1111/J.2042-7158.1996.Tb05882.X  0.089
1990 Heilig M, Vècséi L, Wahlestedt C, Alling C, Widerlöv E. Effects of centrally administered neuropeptide Y (NPY) and NPY13-36 on the brain monoaminergic systems of the rat. Journal of Neural Transmission. General Section. 79: 193-208. PMID 2297403 DOI: 10.1007/Bf01245130  0.089
1990 Wahlestedt C, HÃ¥kanson R, Vaz CA, Zukowska-Grojec Z. Norepinephrine and neuropeptide Y: vasoconstrictor cooperation in vivo and in vitro. The American Journal of Physiology. 258: R736-42. PMID 1969241 DOI: 10.1152/Ajpregu.1990.258.3.R736  0.089
1991 Grundemar L, Wahlestedt C, Reis DJ. Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem. The Journal of Pharmacology and Experimental Therapeutics. 258: 633-8. PMID 1678015  0.089
1995 Sun XY, Edvinsson L, Yoo H, Wahlestedt C, Hedner T. Effects of some novel D-myo-inositol-phosphate derivatives on binding and sympathetic transmission. Journal of Cardiovascular Pharmacology. 25: 696-704. PMID 7630147  0.089
1986 Wahlestedt C, Yanaihara N, HÃ¥kanson R. Evidence for different pre-and post-junctional receptors for neuropeptide Y and related peptides. Regulatory Peptides. 13: 307-18. PMID 3010387 DOI: 10.1016/0167-0115(86)90048-0  0.088
2002 Li J, Protopopov A, Wang F, Senchenko V, Petushkov V, Vorontsova O, Petrenko L, Zabarovska V, Muravenko O, Braga E, Kisselev L, Lerman MI, Kashuba V, Klein G, Ernberg I, ... Wahlestedt C, et al. NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes. Proceedings of the National Academy of Sciences of the United States of America. 99: 10724-9. PMID 12149436 DOI: 10.1073/Pnas.132271699  0.087
1992 Wahlestedt C, Reis DJ, Yoo H, Adamsson M, Andersson D, Edvinsson L. A novel inositol phosphate selectively inhibits vasoconstriction evoked by the sympathetic co-transmitters neuropeptide Y (NPY) and adenosine triphosphate (ATP). Neuroscience Letters. 143: 123-6. PMID 1436655 DOI: 10.1016/0304-3940(92)90247-5  0.087
2016 Esanov R, Andrade NS, Bennison S, Wahlestedt C, Zeier Z. The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients. Human Molecular Genetics. 25: 4870-4880. PMID 28173181 DOI: 10.1093/hmg/ddw311  0.086
2003 Salmi P, Kela J, Arvidsson U, Wahlestedt C. Functional interactions between delta- and mu-opioid receptors in rat thermoregulation. European Journal of Pharmacology. 458: 101-6. PMID 12498912 DOI: 10.1016/S0014-2999(02)02736-X  0.086
2010 Sonntag KC, Wahlestedt C. RNA mechanisms in CNS systems and disorders. Brain Research. 1338: 1-2. PMID 20380824 DOI: 10.1016/j.brainres.2010.04.007  0.086
1997 Pepin MC, Yue SY, Roberts E, Wahlestedt C, Walker P. Novel "restoration of function" mutagenesis strategy to identify amino acids of the delta-opioid receptor involved in ligand binding. The Journal of Biological Chemistry. 272: 9260-7. PMID 9083060 DOI: 10.1074/jbc.272.14.9260  0.085
2002 Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, ... Wahlestedt C, et al. NotI flanking sequences: a tool for gene discovery and verification of the human genome. Nucleic Acids Research. 30: 3163-70. PMID 12136098 DOI: 10.1093/Nar/Gkf428  0.084
1987 Larsson LT, Malmfors G, Wahlestedt C, Leander S, HÃ¥kanson R. Hirschsprung's disease: a comparison of the nervous control of ganglionic and aganglionic smooth muscle in vitro. Journal of Pediatric Surgery. 22: 431-5. PMID 3585666  0.083
2004 Elmén J, Zhang HY, Zuber B, Ljungberg K, Wahren B, Wahlestedt C, Liang Z. Locked nucleic acid containing antisense oligonucleotides enhance inhibition of HIV-1 genome dimerization and inhibit virus replication. Febs Letters. 578: 285-90. PMID 15589834 DOI: 10.1016/J.Febslet.2004.11.015  0.082
1993 Wahlestedt C, Golanov E, Yamamoto S, Yee F, Ericson H, Yoo H, Inturrisi CE, Reis DJ. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature. 363: 260-3. PMID 8487863 DOI: 10.1038/363260A0  0.081
2001 Li J, Wang F, Kashuba V, Wahlestedt C, Zabarovsky ER. Cloning of deleted sequences (CODE): A genomic subtraction method for enriching and cloning deleted sequences. Biotechniques. 31: 788, 790, 792-3. PMID 11680709 DOI: 10.2144/01314St05  0.078
1994 Wahlestedt C. Antisense oligonucleotide strategies in neuropharmacology. Trends in Pharmacological Sciences. 15: 42-6. PMID 8165722 DOI: 10.1016/0165-6147(94)90107-4  0.078
1991 Wahlestedt C, Karoum F, Jaskiw G, Wyatt RJ, Larhammar D, Ekman R, Reis DJ. Cocaine-induced reduction of brain neuropeptide Y synthesis dependent on medial prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 88: 2078-82. PMID 2006146 DOI: 10.1073/Pnas.88.6.2078  0.077
2000 Zabarovsky ER, Gizatullin R, Podowski RM, Zabarovska VV, Xie L, Muravenko OV, Kozyrev S, Petrenko L, Skobeleva N, Li J, Protopopov A, Kashuba V, Ernberg I, Winberg G, Wahlestedt C. NotI clones in the analysis of the human genome. Nucleic Acids Research. 28: 1635-9. PMID 10710430 DOI: 10.1093/Nar/28.7.1635  0.076
1992 Regunathan S, Reis DJ, Wahlestedt C. Specific binding of inositol hexakisphosphate (phytic acid) to adrenal chromaffin cell membranes and effects on calcium-dependent catecholamine release. Biochemical Pharmacology. 43: 1331-6. PMID 1562283 DOI: 10.1016/0006-2952(92)90510-P  0.076
2008 Huang J, Young B, Pletcher MT, Heilig M, Wahlestedt C. Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence. Addiction Biology. 13: 88-94. PMID 18269382 DOI: 10.1111/J.1369-1600.2007.00089.X  0.076
2017 Khomtchouk BB, Hennessy JR, Wahlestedt C. shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics. Plos One. 12: e0176334. PMID 28493881 DOI: 10.1371/journal.pone.0176334  0.075
1985 Bynke G, Wahlestedt C, Beding B, HÃ¥kanson R. Pupillary supersensitivity to substance P following prolonged treatment with tetrodotoxin or substance P antagonists. European Journal of Pharmacology. 108: 217-23. PMID 2580717  0.074
2000 Protopopov A, Kashuba V, Podowski R, Gizatullin R, Sonnhammer E, Wahlestedt C, Zabarovsky ER. Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization. Cytogenetics and Cell Genetics. 88: 312-3. PMID 10828617 DOI: 10.1159/000015516  0.072
2013 Gidlöf O, van der Brug M, Ohman J, Gilje P, Olde B, Wahlestedt C, Erlinge D. Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression. Blood. 121: 3908-17, S1-26. PMID 23493781 DOI: 10.1182/Blood-2012-10-461798  0.071
2010 van der Brug MP, Wahlestedt C. Navigating genomic maps of cancer cells. Nature Biotechnology. 28: 241-2. PMID 20212487 DOI: 10.1038/nbt0310-241  0.07
2000 Zabarovska V, Li J, Muravenko O, Fedorova L, Braga E, Ernberg I, Wahlestedt C, Klein G, Zabarovsky ER. CIS--cloning of identical sequences between two complex genomes. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 8: 77-84. PMID 10730592 DOI: 10.1023/A:1009243606611  0.07
2003 Zhu G, Pollak L, Mottagui-Tabar S, Wahlestedt C, Taubman J, Virkkunen M, Goldman D, Heilig M. NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations. Alcoholism, Clinical and Experimental Research. 27: 19-24. PMID 12544000 DOI: 10.1111/J.1530-0277.2003.Tb02715.X  0.07
1984 Wahlestedt C, Bynke G, HÃ¥kanson R. Pupillary constriction by bradykinin and capsaicin: mode of action. European Journal of Pharmacology. 106: 577-83. PMID 6083873 DOI: 10.1016/0014-2999(84)90061-X  0.069
2006 Timmons JA, Norrbom J, Schéele C, Thonberg H, Wahlestedt C, Tesch P. Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes. Genomics. 87: 165-72. PMID 16326070 DOI: 10.1016/J.Ygeno.2005.09.007  0.068
2003 Zhang HY, Mao J, Zhou D, Xu Y, Thonberg H, Liang Z, Wahlestedt C. mRNA accessible site tagging (MAST): a novel high throughput method for selecting effective antisense oligonucleotides. Nucleic Acids Research. 31: e72. PMID 12853649  0.068
1990 Grundemar L, Wahlestedt C, Shen GH, Zukowska-Grojec Z, HÃ¥kanson R. Biphasic blood pressure response to neuropeptide Y in anesthetized rats. European Journal of Pharmacology. 179: 83-7. PMID 2364989  0.067
2001 Cao R, Brakenhielm E, Wahlestedt C, Thyberg J, Cao Y. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proceedings of the National Academy of Sciences of the United States of America. 98: 6390-5. PMID 11344271 DOI: 10.1073/Pnas.101564798  0.066
1994 Yee F, Ericson H, Reis DJ, Wahlestedt C. Cellular uptake of intracerebroventricularly administered biotin- or digoxigenin-labeled antisense oligodeoxynucleotides in the rat. Cellular and Molecular Neurobiology. 14: 475-86. PMID 7621508 DOI: 10.1007/Bf02088832  0.066
1990 Brooker G, Seki T, Croll D, Wahlestedt C. Calcium wave evoked by activation of endogenous or exogenously expressed receptors in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 87: 2813-7. PMID 2157216  0.065
2002 Zabarovska VI, Gizatullin RZ, Al-Amin AN, Podowski R, Protopopov AI, Löfdahl S, Wahlestedt C, Winberg G, Kashuba VI, Ernberg I, Zabarovsky ER. A new approach to genome mapping and sequencing: slalom libraries. Nucleic Acids Research. 30: E6. PMID 11788732 DOI: 10.1093/Nar/30.2.E6  0.065
2003 Eriksson A, Cao R, Roy J, Tritsaris K, Wahlestedt C, Dissing S, Thyberg J, Cao Y. Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability. Circulation. 107: 1532-8. PMID 12654612 DOI: 10.1161/01.CIR.0000055324.34758.32  0.064
2014 Khomtchouk BB, Van Booven DJ, Wahlestedt C. HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline. Source Code For Biology and Medicine. 9: 30. PMID 25550709 DOI: 10.1186/S13029-014-0030-2  0.064
2016 Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, Gallinat J, Giedd J, Grayson DR, Heinrichs M, Kahn R, Krebs MO, Leboyer M, Lewis D, Marin O, ... ... Wahlestedt C, et al. Altering the course of schizophrenia: progress and perspectives. Nature Reviews. Drug Discovery. PMID 26939910 DOI: 10.1038/Nrd.2016.28  0.064
1985 Wahlestedt C, Edvinsson L, Ekblad E, HÃ¥kanson R. Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction: mode of action. The Journal of Pharmacology and Experimental Therapeutics. 234: 735-41. PMID 3928874  0.063
1985 Ekblad E, Wahlestedt C, HÃ¥kanson R, Sundler F, Watanabe T, Wada H. Is histamine a neurotransmitter in the gut? Evidence from histidine decarboxylase immunocytochemistry. Acta Physiologica Scandinavica. 123: 225-7. PMID 2858961 DOI: 10.1111/J.1748-1716.1985.Tb07582.X  0.063
2004 Gu HF, Abulaiti A, Ostenson CG, Humphreys K, Wahlestedt C, Brookes AJ, Efendic S. Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians. Diabetes. 53: S31-5. PMID 14749263 DOI: 10.2337/Diabetes.53.2007.S31  0.062
1985 Ekblad E, HÃ¥kanson R, Sundler F, Wahlestedt C. Galanin: neuromodulatory and direct contractile effects on smooth muscle preparations. British Journal of Pharmacology. 86: 241-6. PMID 2413937 DOI: 10.1111/J.1476-5381.1985.Tb09455.X  0.062
1991 Grundemar L, Wahlestedt C, Reis DJ. Long-lasting inhibition of the cardiovascular responses to glutamate and the baroreceptor reflex elicited by neuropeptide Y injected into the nucleus tractus solitarius of the rat. Neuroscience Letters. 122: 135-9. PMID 1676143 DOI: 10.1016/0304-3940(91)90211-B  0.061
1987 Kannisto P, HÃ¥kanson R, Owman C, Schmidt G, Wahlestedt C. GABA suppresses stimulation-induced release of [3H]-noradrenaline from sympathetic nerve fibres in bovine ovarian follicles. Journal of Autonomic Pharmacology. 7: 339-47. PMID 3127396 DOI: 10.1111/J.1474-8673.1987.Tb00162.X  0.061
1994 Yoo H, Fallgren B, Lindahl A, Wahlestedt C. Characterization of specific binding sites for alpha-trinositol (D-myo-inositol 1,2,6-trisphosphate) in rat tissues. European Journal of Pharmacology. 268: 55-63. PMID 7925612 DOI: 10.1016/0922-4106(94)90119-8  0.06
1992 Sun MK, Wahlestedt C, Reis DJ. Inositol hexakisphosphate excites rat medullary sympathoexcitatory neurons in vivo. European Journal of Pharmacology. 215: 9-16. PMID 1516653 DOI: 10.1016/0014-2999(92)90601-Y  0.06
1987 Wahlestedt C, Wohlfart B, HÃ¥kanson R. Effects of neuropeptide Y (NPY) on isolated guinea-pig heart. Acta Physiologica Scandinavica. 129: 459-63. PMID 3591369 DOI: 10.1111/J.1365-201X.1987.Tb10618.X  0.06
1999 Kashuba VI, Gizatullin RZ, Protopopov AI, Li J, Vorobieva NV, Fedorova L, Zabarovska VI, Muravenko OV, Kost-Alimova M, Domninsky DA, Kiss C, Allikmets R, Zakharyev VM, Braga EA, Sumegi J, ... ... Wahlestedt C, et al. Analysis of NotI linking clones isolated from human chromosome 3 specific libraries. Gene. 239: 259-71. PMID 10548727 DOI: 10.1016/S0378-1119(99)00411-4  0.059
1986 HÃ¥kanson R, Wahlestedt C, Ekblad E, Edvinsson L, Sundler F. Neuropeptide Y: coexistence with noradrenaline. Functional implications. Progress in Brain Research. 68: 279-87. PMID 3550891  0.059
2007 St Laurent G, Wahlestedt C. Noncoding RNAs: couplers of analog and digital information in nervous system function? Trends in Neurosciences. 30: 612-21. PMID 17996312 DOI: 10.1016/j.tins.2007.10.002  0.058
2023 Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, Cabezas J, Lozano JJ, Van Booven D, Bell A, Cao S, Vernetti LA, Arab JP, Ventura-Cots M, Edmunds LR, ... ... Wahlestedt C, et al. Author Correction: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nature Communications. 14: 757. PMID 36765087 DOI: 10.1038/s41467-023-36548-3  0.057
2002 Larsson O, Thormeyer D, Asinger A, Wihlén B, Wahlestedt C, Liang Z. Quantitative codon optimisation of DNA libraries encoding sub-random peptides: design and characterisation of a novel library encoding transmembrane domain peptides. Nucleic Acids Research. 30: e133. PMID 12466565 DOI: 10.1093/Nar/Gnf133  0.057
2007 Carninci P, Sandelin A, Lenhard B, Katayama S, Shimokawa K, Ponjavic J, Semple CAM, Taylor MS, Engström G PG, Frith MC, Forrest ARR, Alkema WB, Tan SL, Plessy C, Kodzius R, ... ... Wahlestedt C, et al. Erratum: Corrigendum: Genome-wide analysis of mammalian promoter architecture and evolution Nature Genetics. 39: 1174-1174. DOI: 10.1038/Ng0907-1174B  0.056
1987 HÃ¥kanson R, Beding B, Ekman R, Heilig M, Wahlestedt C, Sundler F. Multiple tachykinin pools in sensory nerve fibres in the rabbit iris. Neuroscience. 21: 943-50. PMID 2442656 DOI: 10.1016/0306-4522(87)90049-2  0.055
1987 Wahlestedt C, Skagerberg G, Ekman R, Heilig M, Sundler F, HÃ¥kanson R. Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Research. 417: 33-8. PMID 3040184 DOI: 10.1016/0006-8993(87)90176-4  0.055
1983 HÃ¥kanson R, Wahlestedt C, Westlin L, Vallgren S, Sundler F. Neuronal histamine in the gut wall releasable by gastrin and cholecystokinin. Neuroscience Letters. 42: 305-10. PMID 6320074 DOI: 10.1016/0304-3940(83)90279-3  0.054
2000 Li J, Wang F, Zabarovska V, Wahlestedt C, Zabarovsky ER. Cloning of polymorphisms (COP): enrichment of polymorphic sequences from complex genomes. Nucleic Acids Research. 28: e1. PMID 10606669 DOI: 10.1093/Nar/28.2.E1  0.054
2002 Ding B, Bertilsson L, Wahlestedt C. The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population. Journal of Clinical Pharmacy and Therapeutics. 27: 211-2. PMID 12081635 DOI: 10.1046/j.1365-2710.2002.00409.x  0.054
1985 Wahlestedt C, Bynke G, Beding B, von Leithner P, HÃ¥kanson R. Neurogenic mechanisms in control of the rabbit iris sphincter muscle. European Journal of Pharmacology. 117: 303-9. PMID 3865781 DOI: 10.1016/0014-2999(85)90003-2  0.054
1986 Ekman R, Wahlestedt C, Böttcher G, Sundler F, HÃ¥kanson R, Panula P. Peptide YY-like immunoreactivity in the central nervous system of the rat. Regulatory Peptides. 16: 157-68. PMID 3544089 DOI: 10.1016/0167-0115(86)90059-5  0.053
1993 Zukowska-Grojec Z, Golczynska M, Shen GH, Torres-Duarte A, Haass M, Wahlestedt C, Myers AK. Modulation of vascular function by neuropeptide Y during development of hypertension in spontaneously hypertensive rats. Pediatric Nephrology (Berlin, Germany). 7: 845-52. PMID 7907499 DOI: 10.1007/Bf01213372  0.053
1990 Wahlestedt C, Karoum F, Jaskiw G, Larhammar D, Ekman D, Reis D. Lesion of medial prefrontal cortex prevents cocaine-induced reduction of forebrain neuropeptide Y synthesis European Journal of Pharmacology. 183: 655. DOI: 10.1016/0014-2999(90)92441-K  0.053
2001 Schrimpf SP, Langen H, Gomes AV, Wahlestedt C. A two-dimensional protein map of Caenorhabditis elegans. Electrophoresis. 22: 1224-32. PMID 11358149 DOI: 10.1002/1522-2683()22:6<1224::AID-ELPS1224>3.0.CO;2-I  0.05
2007 Timmons JA, Scheele C, Wahlestedt C. Do mitochondria provide a common link between diabetes and Parkinson's disease? Practical Diabetes International. 24: 337-339. DOI: 10.1002/Pdi.1136  0.049
1986 Wahlestedt C, Beding B, Ekman R, Oksala O, Stjernschantz J, HÃ¥kanson R. Calcitonin gene-related peptide in the eye: release by sensory nerve stimulation and effects associated with neurogenic inflammation. Regulatory Peptides. 16: 107-15. PMID 2433715  0.047
1990 GRUNDEMAR L, WAHLESTEDT C, SHEN GH, ZUKOWSKA-GROJEC Z, HÅKANSON R. High Doses of Neuropeptide Y Reduce Blood Pressure in Anesthetized Rats Annals of the New York Academy of Sciences. 611: 415-417. DOI: 10.1111/J.1749-6632.1990.Tb48969.X  0.047
1984 Edvinsson L, Ekblad E, HÃ¥kanson R, Wahlestedt C. Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. British Journal of Pharmacology. 83: 519-25. PMID 6593107 DOI: 10.1111/J.1476-5381.1984.Tb16516.X  0.044
1990 Häppölä O, Wahlestedt C, Ekman R, Soinila S, Panula P, HÃ¥kanson R. Peptide YY-like immunoreactivity in sympathetic neurons of the rat. Neuroscience. 39: 225-30. PMID 2089278 DOI: 10.1016/0306-4522(90)90235-V  0.044
1985 Edvinsson L, HÃ¥kanson R, Steen S, Sundler F, Uddman R, Wahlestedt C. Innervation of human omental arteries and veins and vasomotor response to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide. Regulatory Peptides. 12: 67-79. PMID 2416012 DOI: 10.1016/0167-0115(85)90188-0  0.041
1992 Sun MK, Wahlestedt C, Reis DJ. Action of externally applied ATP on rat reticulospinal vasomotor neurons. European Journal of Pharmacology. 224: 93-6. PMID 1451746 DOI: 10.1016/0014-2999(92)94824-F  0.038
1998 Wahlestedt C. Reward for persistence in substance P research. Science (New York, N.Y.). 281: 1624-5. PMID 9767028 DOI: 10.1126/science.281.5383.1624  0.037
2001 Wahlestedt C. Using genomics to understand the nervous system Drug Discovery Today. 6: S81-S85.  0.037
1986 Sundler F, HÃ¥kanson R, Ekblad E, Uddman R, Wahlestedt C. Neuropeptide Y in the peripheral adrenergic and enteric nervous systems. International Review of Cytology. 102: 243-69. PMID 3533828  0.035
1984 Ekblad E, Edvinsson L, Wahlestedt C, Uddman R, HÃ¥kanson R, Sundler F. Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. Regulatory Peptides. 8: 225-35. PMID 6379758  0.035
1985 Wahlestedt C, Skagerberg G, HÃ¥kanson R, Sundler F, Wada H, Watanabe T. Spinal projections of hypothalamic histidine decarboxylase-immunoreactive neurones. Agents and Actions. 16: 231-3. PMID 4013912 DOI: 10.1007/Bf01983147  0.029
2016 Khomtchouk BB, Weitz E, Karp PD, Wahlestedt C. How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications. Briefings in Bioinformatics. PMID 28040748 DOI: 10.1093/bib/bbw130  0.027
1990 MYERS AK, FARHAT MY, SHEN GH, DEBINSKI W, WAHLESTEDT C, ZUKOWSKA-GROJEC Z. Platelets as a Source and Site of Action for Neuropeptide Y Annals of the New York Academy of Sciences. 611: 408-411. DOI: 10.1111/j.1749-6632.1990.tb48967.x  0.02
2003 Wahlestedt C. Array of possibilities. Pharmacogenetics. 13: 1. PMID 12544506 DOI: 10.1097/00008571-200301000-00001  0.016
2017 Khomtchouk BB, Weitz E, Karp PD, Wahlestedt C. How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications. Briefings in Bioinformatics. PMID 28334156 DOI: 10.1093/bib/bbx016  0.014
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