Stephen J. Tucker - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
Area:
Ion Channel Biophysics

124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lynch CI, Klesse G, Rao S, Tucker SJ, Sansom MSP. Water Nanoconfined in a Hydrophobic Pore: Molecular Dynamics Simulations of Transmembrane Protein 175 and the Influence of Water Models. Acs Nano. PMID 34784172 DOI: 10.1021/acsnano.1c06443  0.46
2021 Conrad LJ, Proks P, Tucker SJ. Effects of ionic strength on gating and permeation of TREK-2 K2P channels. Plos One. 16: e0258275. PMID 34618865 DOI: 10.1371/journal.pone.0258275  0.397
2021 Proks P, Schewe M, Conrad LJ, Rao S, Rathje K, Rödström KEJ, Carpenter EP, Baukrowitz T, Tucker SJ. Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate. The Journal of General Physiology. 153. PMID 34032848 DOI: 10.1085/jgp.202012812  0.731
2021 Sachse G, Haythorne E, Hill T, Proks P, Joynson R, Terrón-Expósito R, Bentley L, Tucker SJ, Cox RD, Ashcroft FM. The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion. Diabetes. PMID 33568422 DOI: 10.2337/db20-0691  0.443
2021 Rao S, Klesse G, Lynch CI, Tucker SJ, Sansom MSP. Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions. The Journal of Physical Chemistry. B. PMID 33439645 DOI: 10.1021/acs.jpcb.0c09285  0.555
2020 Klesse G, Tucker SJ, Sansom MSP. Electric Field Induced Wetting of a Hydrophobic Gate in a Model Nanopore Based on the 5-HT Receptor Channel. Acs Nano. PMID 32673478 DOI: 10.1021/Acsnano.0C04387  0.403
2020 Rödström KEJ, Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, ... ... Tucker SJ, et al. A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature. PMID 32499642 DOI: 10.1038/S41586-020-2250-8  0.366
2020 Imbrici P, Nematian-Ardestani E, Hasan S, Pessia M, Tucker SJ, D'Adamo MC. Altered functional properties of a missense variant in the TRESK K channel (KCNK18) associated with migraine and intellectual disability. Pflugers Archiv : European Journal of Physiology. PMID 32394190 DOI: 10.1007/S00424-020-02382-5  0.35
2020 Klesse G, Rao S, Tucker SJ, Sansom MSP. Induced Polarization in MD Simulations of the 5HT3 Receptor Channel. Journal of the American Chemical Society. PMID 32336093 DOI: 10.1021/Jacs.0C02394  0.436
2020 Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H. Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins. Nature Structural & Molecular Biology. PMID 32066965 DOI: 10.1038/S41594-020-0396-6  0.635
2020 Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H. Structure and assembly of calcium homeostasis modulator proteins. Nature Structural & Molecular Biology. PMID 31988524 DOI: 10.1038/s41594-019-0369-9  0.74
2020 Rao S, Klesse G, Tucker SJ, Sansom MS. Annotating Ion Channel Pores: Structures, Hydrophobicity and the Threshold for Permeation Biophysical Journal. 118: 272a. DOI: 10.1016/J.Bpj.2019.11.1565  0.359
2019 Nematian-Ardestani E, Abd-Wahab MF, Chatelain FC, Sun H, Schewe M, Baukrowitz T, Tucker SJ. Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ Channel. The Journal of Biological Chemistry. PMID 31806709 DOI: 10.1074/Jbc.Ra119.010612  0.722
2019 Rao S, Klesse G, Stansfeld PJ, Tucker SJ, Sansom MSP. A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates. Proceedings of the National Academy of Sciences of the United States of America. PMID 31235590 DOI: 10.1073/Pnas.1902702116  0.53
2019 Klesse G, Rao S, Sansom MSP, Tucker SJ. CHAP: A Versatile Tool for the Structural and Functional Annotation of Ion Channel Pores. Journal of Molecular Biology. PMID 31220459 DOI: 10.1016/J.Jmb.2019.06.003  0.531
2019 Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, ... ... Tucker SJ, et al. A pharmacological master key mechanism that unlocks the selectivity filter gate in K channels. Science (New York, N.Y.). 363: 875-880. PMID 30792303 DOI: 10.1126/Science.Aav0569  0.721
2019 Schewe M, Sun H, Mackenzie A, Pike ACW, Schulz F, Constantin C, Kiper AK, Conrad LJ, Gonzalez W, Groot BLd, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T. A Pharmacological Masterkey Mechanism to Unlock the Selectivity Filter Gate in K+ Channels Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1635  0.602
2019 Rao S, Klesse G, Stansfeld PJ, Tucker SJ, Sansom MS. Functional Annotation of Ion Channel Structures: Predicting Pore Solvation States Based on Local Radius and Hydrophobicity Biophysical Journal. 116: 241a. DOI: 10.1016/J.Bpj.2018.11.1321  0.359
2018 Rao S, Lynch CI, Klesse G, Oakley GE, Stansfeld PJ, Tucker SJ, Sansom MSP. Water and hydrophobic gates in ion channels and nanopores. Faraday Discussions. PMID 29969132 DOI: 10.1039/C8Fd00013A  0.53
2018 Rao S, Klesse G, Tucker SJ, Sansom MS. Hydrophobic Gating: Examination of Recent Ion Channel Structures Biophysical Journal. 114: 134a. DOI: 10.1016/J.Bpj.2017.11.762  0.359
2018 Klesse G, Rao S, Stansfeld PJ, Sansom MS, Tucker SJ. A Newly Available Tool for Functional Annotation of Ion Channel Structures Based on Molecular Dynamics Simulations Biophysical Journal. 114: 134a. DOI: 10.1016/J.Bpj.2017.11.761  0.359
2017 Clausen MV, Jarerattanachat V, Carpenter EP, Sansom MSP, Tucker SJ. Asymmetric mechanosensitivity in a eukaryotic ion channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923939 DOI: 10.1073/Pnas.1708990114  0.531
2017 Nematian-Ardestani E, Jarerattanachat V, Aryal P, Sansom MSP, Tucker SJ. The Effects of Stretch Activation on Ionic Selectivity of the TREK-2 K2P K(+) Channel. Channels (Austin, Tex.). 0. PMID 28723241 DOI: 10.1080/19336950.2017.1356955  0.736
2017 Lacin E, Aryal P, Glaaser IW, Bodhinathan K, Tsai E, Marsh N, Tucker SJ, Sansom MSP, Slesinger PA. Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel. The Journal of General Physiology. PMID 28720589 DOI: 10.1085/Jgp.201711801  0.837
2017 Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike AC, Carpenter EP, Baukrowitz T, Sansom MS, Tucker SJ. Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure (London, England : 1993). PMID 28392258 DOI: 10.1016/J.Str.2017.03.006  0.819
2017 Rao S, Klesse G, Stansfeld PJ, Tucker SJ, Sansom MS. A BEST Example of Channel Structure Annotation by Molecular Simulation. Channels (Austin, Tex.). 0. PMID 28319451 DOI: 10.1080/19336950.2017.1306163  0.553
2017 Jarerattanachat V, Clausen MV, Aryal P, Carpenter EP, Sansom MS, Tucker SJ. Structural and Functional Response of a Mechanosensitive K2P K + Channel to Asymmetric Membrane Tension Biophysical Journal. 112: 545a. DOI: 10.1016/J.Bpj.2016.11.2945  0.653
2017 Klesse G, Trick J, Chelvaniththilan S, Aryal P, Wallace J, Tucker S, Sansom MSP. Hydrophobic Gating and Functional Annotation of Ion Channel Structures by Molecular Dynamics Simulations Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.2233  0.653
2017 Clausen MV, Jarerattanachat V, Ang J, Carpenter L, Tucker S. TREK-2 Has an Asymmetrical Response to Force Changes in the Membrane Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1688  0.338
2017 Tucker SJ. Structural Mechanisms of Mechanosensitivity in the TREK-2 K2P Potassium Channel Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.073  0.394
2016 Trick JL, Chelvaniththilan S, Klesse G, Aryal P, Wallace EJ, Tucker SJ, Sansom MS. Functional Annotation of Ion Channel Structures by Molecular Simulation. Structure (London, England : 1993). PMID 27866853 DOI: 10.1016/J.Str.2016.10.005  0.725
2016 Sadler EE, Kapanidis AN, Tucker SJ. Solution-Based Single-Molecule FRET Studies of K(+) Channel Gating in a Lipid Bilayer. Biophysical Journal. 110: 2663-70. PMID 27332124 DOI: 10.1016/J.Bpj.2016.05.020  0.346
2016 McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. The Journal of General Physiology. 147: 497-505. PMID 27241700 DOI: 10.1085/Jgp.201611601  0.831
2016 Reed AP, Bucci G, Abd-Wahab F, Tucker SJ. Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy. Plos One. 11: e0156456. PMID 27228168 DOI: 10.1371/Journal.Pone.0156456  0.37
2016 Schewe M, Nematian-Ardestani E, Sun H, Musinszki M, Cordeiro S, Bucci G, de Groot BL, Tucker SJ, Rapedius M, Baukrowitz T. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels. Cell. 164: 937-49. PMID 26919430 DOI: 10.1016/J.Cell.2016.02.002  0.72
2016 McClenaghan C, Schewe M, Baukrowitz T, Tucker SJ. Polymodal Gating of the TREK-2 K2P Potassium Channel Involves Structurally Distinct Open States Biophysical Journal. 110: 607. DOI: 10.1016/J.Bpj.2015.11.3241  0.843
2016 Aryal P, Jarerattanachat V, Tucker SJ, Sansom MS. Bilayer-Mediated Structural Transitions in the TREK-2 Mechanosensitive K2P Channel Biophysical Journal. 110: 348a. DOI: 10.1016/J.Bpj.2015.11.1874  0.764
2016 Schewe M, Nematian-Ardestani E, Sun H, Musinszki M, Cordeiro S, Bucci G, Groot BLd, Tucker SJ, Rapedius M, Baukrowitz T. A non-canonical voltage sensor controls gating in K2P K+ channels. Biophysical Journal. 110: 937-949. DOI: 10.1016/J.Bpj.2015.11.1502  0.72
2015 Zubcevic L, Wang S, Bavro VN, Lee SJ, Nichols CG, Tucker SJ. Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels. Scientific Reports. 5: 15305. PMID 26470642 DOI: 10.1038/Srep15305  0.786
2015 Beale JH, Parker JL, Samsudin F, Barrett AL, Senan A, Bird LE, Scott D, Owens RJ, Sansom MS, Tucker SJ, Meredith D, Fowler PW, Newstead S. Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport. Structure (London, England : 1993). 23: 1889-99. PMID 26320580 DOI: 10.1016/J.Str.2015.07.016  0.356
2015 Trick JL, Aryal P, Tucker SJ, Sansom MS. Molecular simulation studies of hydrophobic gating in nanopores and ion channels. Biochemical Society Transactions. 43: 146-50. PMID 25849908 DOI: 10.1042/Bst20140256  0.736
2015 Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, ... ... Tucker SJ, et al. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science (New York, N.Y.). 347: 1256-9. PMID 25766236 DOI: 10.1126/Science.1261512  0.84
2015 Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ. Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel. Channels (Austin, Tex.). 9: 44-9. PMID 25487004 DOI: 10.4161/19336950.2014.981987  0.704
2015 Aryal P, Sansom MS, Tucker SJ. Hydrophobic gating in ion channels. Journal of Molecular Biology. 427: 121-30. PMID 25106689 DOI: 10.1016/J.Jmb.2014.07.030  0.723
2015 Beale JH, Parker JL, Samsudin F, Barrett AL, Senan A, Bird LE, Scott D, Owens RJ, Sansom MSP, Tucker SJ, Meredith D, Fowler PW, Newstead S. Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport Structure. DOI: 10.1016/j.str.2015.07.016  0.359
2015 Aryal P, Tucker SJ, Sansom MS. Understanding the Dynamics of K2P Channels in Complex Lipid Bilayers Biophysical Journal. 108: 436a-437a. DOI: 10.1016/J.Bpj.2014.11.2384  0.761
2015 Schewe M, Nematian-Ardestani E, Linke T, Benndorf K, Tucker SJ, Rapedius M, Baukrowitz T. Sensing the Electrochemical K+ Gradient: The Voltage Gating Mechanism in K2P Potassium Channels Biophysical Journal. 108: 427. DOI: 10.1016/J.Bpj.2014.11.2338  0.727
2014 Fowler PW, Bollepalli MK, Rapedius M, Nematian-Ardestani E, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. Insights into the structural nature of the transition state in the Kir channel gating pathway. Channels (Austin, Tex.). 8: 551-5. PMID 25483285 DOI: 10.4161/19336950.2014.962371  0.706
2014 Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ. A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel. Nature Communications. 5: 4377. PMID 25001086 DOI: 10.1038/Ncomms5377  0.756
2014 Bollepalli MK, Fowler PW, Rapedius M, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. State-dependent network connectivity determines gating in a K+ channel. Structure (London, England : 1993). 22: 1037-46. PMID 24980796 DOI: 10.1016/J.Str.2014.04.018  0.762
2014 Veale EL, Al-Moubarak E, Bajaria N, Omoto K, Cao L, Tucker SJ, Stevens EB, Mathie A. Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels. Molecular Pharmacology. 85: 671-81. PMID 24509840 DOI: 10.1124/Mol.113.091199  0.334
2014 Zubcevic L, Bavro VN, Muniz JR, Schmidt MR, Wang S, De Zorzi R, Venien-Bryan C, Sansom MS, Nichols CG, Tucker SJ. Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains. The Journal of Biological Chemistry. 289: 143-51. PMID 24257749 DOI: 10.1074/Jbc.M113.501833  0.813
2014 Pike A, Dong Y, Mackenzie A, McClenaghan C, Mukhopadhyay S, Burgess-Brown N, Tucker S, Carpenter E. Structures of the human two-pore domain potassium channels TREK-1 and TREK-2 Acta Crystallographica Section A. 70. DOI: 10.1107/S2053273314085106  0.683
2014 Bollepalli MK, Fowler PW, Rapedius M, Shang L, Sansom MSP, Tucker SJ, Baukrowitz T. Structural and Thermodynamic Characterization of the Gating Pathway in a K+ Channel Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.888  0.76
2014 Schewe M, Rapedius M, Nematian-Ardestani E, Linke T, Benndorf K, Tucker SJ, Baukrowitz T. A Novel Mechanism of Voltage Sensing and Gating in K2P Potassium Channels Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.4109  0.722
2013 Schmidt MR, Stansfeld PJ, Tucker SJ, Sansom MS. Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel. Biochemistry. 52: 279-81. PMID 23270460 DOI: 10.1021/Bi301350S  0.423
2013 Schmidt MR, Aryal P, Tucker SJ, Sansom MS. K2P and Kir K+ Channels in Physiological Bilayers Biophysical Journal. 104: 132a. DOI: 10.1016/J.Bpj.2012.11.754  0.748
2012 Rapedius M, Schmidt MR, Sharma C, Stansfeld PJ, Sansom MS, Baukrowitz T, Tucker SJ. State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels (Austin, Tex.). 6: 473-8. PMID 22991046 DOI: 10.4161/Chan.22153  0.738
2012 Andres-Enguix I, Shang L, Stansfeld PJ, Morahan JM, Sansom MS, Lafrenière RG, Roy B, Griffiths LR, Rouleau GA, Ebers GC, Cader ZM, Tucker SJ. Functional analysis of missense variants in the TRESK (KCNK18) K channel. Scientific Reports. 2: 237. PMID 22355750 DOI: 10.1038/Srep00237  0.51
2012 Bavro VN, De Zorzi R, Schmidt MR, Muniz JR, Zubcevic L, Sansom MS, Vénien-Bryan C, Tucker SJ. Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating. Nature Structural & Molecular Biology. 19: 158-63. PMID 22231399 DOI: 10.1038/Nsmb.2208  0.8
2012 Rapedius M, Piechotta PL, Stansfeld PJ, Bollepalli MK, Ehrlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T. Structural and Mechanistic Insights into Gating of K2P Channels Biophysical Journal. 102: 121a. DOI: 10.1016/J.Bpj.2011.11.678  0.772
2012 Zorzi RD, Nicholson WV, Tucker SJ, Vénien-Bryan C. Comparison of the Structure of a Bacterial Potassium Channel in Both 2D and 3D Crystals Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2929  0.357
2012 Bavro VN, De Zorzi R, Schmidt MR, Muniz JR, Zubcevic L, Sansom MS, Venien-Bryan C, Tucker SJ. Crystal Structure of a Prokaryotic Kir Channel in an Open Conformation Biophysical Journal. 102: 536a. DOI: 10.1016/J.Bpj.2011.11.2928  0.802
2011 Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Ehrlich G, Erhlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T. The pore structure and gating mechanism of K2P channels. The Embo Journal. 30: 3607-19. PMID 21822218 DOI: 10.1038/Emboj.2011.268  0.774
2011 Leptihn S, Thompson JR, Ellory JC, Tucker SJ, Wallace MI. In vitro reconstitution of eukaryotic ion channels using droplet interface bilayers. Journal of the American Chemical Society. 133: 9370-5. PMID 21591742 DOI: 10.1021/Ja200128N  0.34
2011 Schmidt MR, Stansfeld PJ, Rapedius M, Baukrowitz T, Tucker SJ, Sansom MS. PIP2-Binding to an Open State Model of Kir1.1 Probed by Multiscale Biomolecular Simulations Biophysical Journal. 100: 431a. DOI: 10.1016/J.Bpj.2010.12.2547  0.746
2011 Sharma C, Bollepalli MK, Baukrowitz T, Tucker SJ. Identification of Gating Mutations in the Trek-1 k2p Potassium Channel by Functional Complementation in K+ uptake Deficient Yeast Biophysical Journal. 100: 279a-280a. DOI: 10.1016/J.Bpj.2010.12.1734  0.718
2011 Andres-Enguix I, Shang L, Stansfeld P, Sansom MS, Cader MZ, Tucker SJ. Functional Analysis of Mutations in the TRESK K2P Potassium Channel Associated with ‘migraine with Aura’ Biophysical Journal. 100: 279a. DOI: 10.1016/J.Bpj.2010.12.1733  0.489
2010 Paynter JJ, Andres-Enguix I, Fowler PW, Tottey S, Cheng W, Enkvetchakul D, Bavro VN, Kusakabe Y, Sansom MS, Robinson NJ, Nichols CG, Tucker SJ. Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains. The Journal of Biological Chemistry. 285: 40754-61. PMID 20876570 DOI: 10.1074/Jbc.M110.175687  0.562
2010 Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, ... ... Tucker SJ, et al. A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. Nature Medicine. 16: 1157-60. PMID 20871611 DOI: 10.1038/Nm.2216  0.336
2010 Paynter JJ, Shang L, Bollepalli MK, Baukrowitz T, Tucker SJ. Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels. Channels (Austin, Tex.). 4: 390-7. PMID 20699659 DOI: 10.4161/Chan.4.5.13006  0.676
2010 Gupta S, Bavro VN, D'Mello R, Tucker SJ, Vénien-Bryan C, Chance MR. Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry. Structure (London, England : 1993). 18: 839-46. PMID 20637420 DOI: 10.1016/J.Str.2010.04.012  0.392
2010 Bollepalli MK, Fowler P, Rapedius M, Xie M, Shang L, Fritzenschaft H, Sansom M, Tucker SJ, Baukrowitz T. A Structural Model of a Kir Channel in the Open State Derived from Mutagenic Scanning of the Pore Gating Energetics Biophysical Journal. 98: 697a. DOI: 10.1016/J.Bpj.2009.12.3825  0.735
2010 Gupta S, D'Mello R, Chance MR, Bavro VN, Venien-Bryan C, Tucker SJ. Radiolytic Footprinting Reveals Conformational Changes During Potassium Channel Gating Biophysical Journal. 98: 696a. DOI: 10.1016/J.Bpj.2009.12.3819  0.39
2010 Piechotta PL, Stansfeld PJ, Bollepalli MK, Rapedius M, Andres-Enguix I, Shang L, Fritzenschaft H, Sansom MS, Tucker S, Baukrowitz T. TREK Channel Pore Probed by Cysteine Scanning Mutagenesis and Structural Modelling Biophysical Journal. 98: 327a. DOI: 10.1016/J.Bpj.2009.12.1773  0.754
2009 Shang L, Ranson SV, Tucker SJ. Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis. Biochemical and Biophysical Research Communications. 388: 501-5. PMID 19665991 DOI: 10.1016/J.Bbrc.2009.08.032  0.376
2009 Imbrici P, Grottesi A, D'Adamo MC, Mannucci R, Tucker SJ, Pessia M. Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties. Channels (Austin, Tex.). 3: 39-45. PMID 19202350 DOI: 10.4161/chan.3.1.7548  0.411
2009 Rapedius M, Bollepalli MK, Tucker SJ, Baukrowitz T. State-dependent Cysteine Modification during pH and PIP2 Gating in Kir Channels Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.2379  0.682
2009 Bollepalli MK, Rapedius M, Fowler P, Xie M, Shang L, Fritzenschaft H, Sansom MS, Tucker SJ, Baukrowitz T. Gating Sensitive Residues In The Pore Of An Inwardly Rectifying Potassium (Kir) Channel Biophysical Journal. 96: 462a. DOI: 10.1016/J.Bpj.2008.12.2378  0.75
2008 Imbrici P, Gualandi F, D'Adamo MC, Masieri MT, Cudia P, De Grandis D, Mannucci R, Nicoletti I, Tucker SJ, Ferlini A, Pessia M. A novel KCNA1 mutation identified in an Italian family affected by episodic ataxia type 1 Neuroscience. 157: 577-587. PMID 18926884 DOI: 10.1016/J.Neuroscience.2008.09.022  0.333
2008 Paynter JJ, Sarkies P, Andres-Enguix I, Tucker SJ. Genetic selection of activatory mutations in KcsA. Channels (Austin, Tex.). 2: 413-8. PMID 18797191 DOI: 10.4161/Chan.2.6.6874  0.355
2008 Tucker SJ, Baukrowitz T. How highly charged anionic lipids bind and regulate ion channels. The Journal of General Physiology. 131: 431-8. PMID 18411329 DOI: 10.1085/Jgp.200709936  0.706
2008 Shang L, Tucker SJ. Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels. European Biophysics Journal : Ebj. 37: 165-71. PMID 17657484 DOI: 10.1007/S00249-007-0206-7  0.396
2007 Rapedius M, Paynter JJ, Fowler PW, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing. Channels (Austin, Tex.). 1: 327-30. PMID 18690035 DOI: 10.4161/Chan.5176  0.741
2007 Rapedius M, Fowler PW, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. H bonding at the helix-bundle crossing controls gating in Kir potassium channels. Neuron. 55: 602-14. PMID 17698013 DOI: 10.1016/J.Neuron.2007.07.026  0.756
2007 Haider S, Khalid S, Tucker SJ, Ashcroft FM, Sansom MS. Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study. Biochemistry. 46: 3643-52. PMID 17326663 DOI: 10.1021/Bi062210F  0.649
2006 Rapedius M, Haider S, Browne KF, Shang L, Sansom MS, Baukrowitz T, Tucker SJ. Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel. Embo Reports. 7: 611-6. PMID 16641935 DOI: 10.1038/Sj.Embor.7400678  0.706
2006 Sun S, Gan JH, Paynter JJ, Tucker SJ. Cloning and functional characterization of a superfamily of microbial inwardly rectifying potassium channels. Physiological Genomics. 26: 1-7. PMID 16595742 DOI: 10.1152/Physiolgenomics.00026.2006  0.319
2005 Rapedius M, Soom M, Shumilina E, Schulze D, Schönherr R, Kirsch C, Lang F, Tucker SJ, Baukrowitz T. Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels. The Journal of Biological Chemistry. 280: 30760-7. PMID 15980413 DOI: 10.1074/Jbc.M503503200  0.689
2003 Casamassima M, D'Adamo MC, Pessia M, Tucker SJ. Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels. The Journal of Biological Chemistry. 278: 43533-40. PMID 12923169 DOI: 10.1074/Jbc.M306596200  0.405
2002 Konstas AA, Dabrowski M, Korbmacher C, Tucker SJ. Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel. The Journal of Biological Chemistry. 277: 21346-51. PMID 11927600 DOI: 10.1074/Jbc.M202005200  0.409
2001 Jones PA, Tucker SJ, Ashcroft FM. Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. Febs Letters. 508: 85-9. PMID 11707273 DOI: 10.1016/S0014-5793(01)03023-X  0.542
2001 Pessia M, Imbrici P, Cristina D'Adamo M, Salvatore L, Tucker SJ. Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1 Journal of Physiology. 532: 359-367. PMID 11306656 DOI: 10.1111/J.1469-7793.2001.0359F.X  0.352
2000 Imbrici P, Tucker SJ, D'Adamo MC, Pessia M. Role of receptor protein tyrosine phosphatase α (RPTPα) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels Pflugers Archiv European Journal of Physiology. 441: 257-262. PMID 11211111 DOI: 10.1007/S004240000406  0.312
2000 Gribble FM, Loussouarn G, Tucker SJ, Zhao C, Nichols CG, Ashcroft FM. A novel method for measurement of submembrane ATP concentration. The Journal of Biological Chemistry. 275: 30046-9. PMID 10866996 DOI: 10.1074/Jbc.M001010200  0.609
2000 Tanabe K, Tucker SJ, Ashcroft FM, Proks P, Kioka N, Amachi T, Ueda K. Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide. Biochemical and Biophysical Research Communications. 272: 316-9. PMID 10833411 DOI: 10.1006/Bbrc.2000.2780  0.484
2000 Tucker SJ, Imbrici P, Salvatore L, D'Adamo MC, Pessia M. pH Dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia Journal of Biological Chemistry. 275: 16404-16407. PMID 10764726 DOI: 10.1074/Jbc.C000127200  0.325
1999 Matsuo M, Tucker SJ, Ashcroft FM, Amachi T, Ueda K. NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1. Febs Letters. 458: 292-4. PMID 10570926 DOI: 10.1016/S0014-5793(99)01170-9  0.487
1999 Tucker SJ, Ashcroft FM. Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. The Journal of Biological Chemistry. 274: 33393-7. PMID 10559219 DOI: 10.1074/Jbc.274.47.33393  0.558
1999 Reimann F, Ryder TJ, Tucker SJ, Ashcroft FM. The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP. The Journal of Physiology. 520: 661-9. PMID 10545134 DOI: 10.1111/J.1469-7793.1999.00661.X  0.547
1999 Reimann F, Tucker SJ, Proks P, Ashcroft FM. Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor. The Journal of Physiology. 518: 325-36. PMID 10381582 DOI: 10.1111/J.1469-7793.1999.0325P.X  0.555
1999 Baukrowitz T, Tucker SJ, Schulte U, Benndorf K, Ruppersberg JP, Fakler B. Inward rectification in K(ATP) channels: A pH switch in the pore Embo Journal. 18: 847-853. PMID 10022827 DOI: 10.1093/Emboj/18.4.847  0.692
1999 Tanabe K, Tucker SJ, Matsuo M, Proks P, Ashcroft FM, Seino S, Amachi T, Ueda K. Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP. The Journal of Biological Chemistry. 274: 3931-3. PMID 9933580 DOI: 10.1074/Jbc.274.7.3931  0.508
1999 Proks P, Gribble FM, Adhikari R, Tucker SJ, Ashcroft FM. Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP. The Journal of Physiology. 514: 19-25. PMID 9831713 DOI: 10.1111/J.1469-7793.1999.019Af.X  0.668
1998 Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP, Fakler B. PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science (New York, N.Y.). 282: 1141-4. PMID 9804555 DOI: 10.1126/Science.282.5391.1141  0.678
1998 Gribble FM, Tucker SJ, Seino S, Ashcroft FM. Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels. Diabetes. 47: 1412-8. PMID 9726229 DOI: 10.2337/Diabetes.47.9.1412  0.657
1998 Trapp S, Proks P, Tucker SJ, Ashcroft FM. Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP. The Journal of General Physiology. 112: 333-49. PMID 9725893 DOI: 10.1085/Jgp.112.3.333  0.591
1998 Trapp S, Tucker SJ, Ashcroft FM. Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification. The Journal of General Physiology. 112: 325-32. PMID 9725892 DOI: 10.1085/Jgp.112.3.325  0.585
1998 Tucker SJ, Ashcroft FM. A touching case of channel regulation: the ATP-sensitive K+ channel. Current Opinion in Neurobiology. 8: 316-20. PMID 9687347 DOI: 10.1016/S0959-4388(98)80055-X  0.575
1998 Tucker SJ, Gribble FM, Proks P, Trapp S, Ryder TJ, Haug T, Reimann F, Ashcroft FM. Molecular determinants of KATP channel inhibition by ATP. The Embo Journal. 17: 3290-6. PMID 9628866 DOI: 10.1093/Emboj/17.12.3290  0.677
1998 Gribble FM, Tucker SJ, Haug T, Ashcroft FM. MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit. Proceedings of the National Academy of Sciences of the United States of America. 95: 7185-90. PMID 9618560 DOI: 10.1073/Pnas.95.12.7185  0.698
1998 Singer TD, Tucker SJ, Marshall WS, Higgins CF. A divergent CFTR homologue: highly regulated salt transport in the euryhaline teleost F. heteroclitus. The American Journal of Physiology. 274: C715-23. PMID 9530103 DOI: 10.1152/Ajpcell.1998.274.3.C715  0.456
1997 Gribble FM, Tucker SJ, Ashcroft FM. The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation. The Journal of Physiology. 504: 35-45. PMID 9350615 DOI: 10.1111/J.1469-7793.1997.00035.X  0.674
1997 Trapp S, Tucker SJ, Ashcroft FM. Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits. Proceedings of the National Academy of Sciences of the United States of America. 94: 8872-7. PMID 9238070 DOI: 10.1073/Pnas.94.16.8872  0.551
1997 Tucker SJ, Gribble FM, Zhao C, Trapp S, Ashcroft FM. Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor. Nature. 387: 179-83. PMID 9144288 DOI: 10.1038/387179A0  0.682
1997 Gribble FM, Tucker SJ, Ashcroft FM. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. The Embo Journal. 16: 1145-52. PMID 9135131 DOI: 10.1093/Emboj/16.6.1145  0.665
1996 Lagrutta AA, Bond CT, Xia XM, Pessia M, Tucker S, Adelman JP. Inward rectifier potassium channels: Cloning, expression and structure-function studies Japanese Heart Journal. 37: 651-660. PMID 8973378 DOI: 10.1536/Ihj.37.651  0.557
1996 Tucker SJ, Pessia M, Adelman JP. Muscarine-gated K+ channel: Subunit stoichiometry and structural domains essential for G protein stimulation American Journal of Physiology - Heart and Circulatory Physiology. 271: H379-H385. PMID 8760196 DOI: 10.1152/Ajpheart.1996.271.1.H379  0.567
1996 Tucker SJ, Pessia M, Moorhouse AJ, Gribble F, Ashcroft FM, Maylie J, Adelman JP. Heteromeric channel formation and Ca2+-free media reduce the toxic effect of the weaver K(ir), 3.2 allele Febs Letters. 390: 253-257. PMID 8706871 DOI: 10.1016/0014-5793(96)00635-7  0.735
1996 Pessia M, Tucker SJ, Lee K, Bond CT, Adelman JP. Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels Embo Journal. 15: 2980-2987. PMID 8670799 DOI: 10.1002/J.1460-2075.1996.Tb00661.X  0.543
1996 Tucker SJ, Bond CT, Herson P, Pessia M, Adelman JP. Inhibitory interactions between two inward rectifier K+ channel subunits mediated by the transmembrane domains Journal of Biological Chemistry. 271: 5866-5870. PMID 8621458 DOI: 10.1074/Jbc.271.10.5866  0.62
1995 Sakura H, Bond C, Warren-Perry M, Horsley S, Kearney L, Tucker S, Adelman J, Turner R, Ashcroft FM. Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit. Febs Letters. 367: 193-7. PMID 7796919 DOI: 10.1016/0014-5793(95)00498-X  0.597
1995 Tucker SJ, James MR, Adelman JP. Assignment of KATP-1, the Cardiac ATP-Sensitive Potassium Channel Gene (KCNJ5), to Human Chromosome 11q24 Genomics. 28: 127-128. PMID 7590741 DOI: 10.1006/Geno.1995.1121  0.474
1992 Tucker SJ, Tannahill D, Higgins CF. Identification and developmental expression of the Xenopus laevis cystic fibrosis transmembrane conductance regulator gene. Human Molecular Genetics. 1: 77-82. PMID 1284470 DOI: 10.1093/Hmg/1.2.77  0.454
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