T L. Steck - Publications

Affiliations: 
University of Chicago, Chicago, IL 
Area:
Pharmaceutical Chemistry, Organic Chemistry, Pharmacology, Microbiology Biology

97 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Steck TL, Ali Tabei SM, Lange Y. Estimating the Cholesterol Affinity of Integral Membrane Proteins from Experimental Data. Biochemistry. 63: 19-26. PMID 38099740 DOI: 10.1021/acs.biochem.3c00567  0.343
2023 Steck TL, Lange Y. Is reverse cholesterol transport regulated by active cholesterol? Journal of Lipid Research. 64: 100385. PMID 37169287 DOI: 10.1016/j.jlr.2023.100385  0.365
2023 Lange Y, Tabei SMA, Steck TL. A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding. Journal of Lipid Research. 100344. PMID 36791915 DOI: 10.1016/j.jlr.2023.100344  0.359
2021 Kerr D, Gong Z, Suwatthee T, Luoma A, Roy S, Scarpaci R, Hwang HL, Henderson JM, Cao KD, Bu W, Lin B, Tietjen GT, Steck TL, Adams EJ, Lee KYC. HOW TIM PROTEINS DIFFERENTIALLY EXPLOIT MEMBRANE FEATURES TO ATTAIN ROBUST TARGET SENSITIVITY. Biophysical Journal. PMID 34529946 DOI: 10.1016/j.bpj.2021.09.016  0.358
2021 Steck TL, Tabei SMA, Lange Y. A basic model for cell cholesterol homeostasis. Traffic (Copenhagen, Denmark). 22: 471-481. PMID 34528339 DOI: 10.1111/tra.12816  0.366
2020 Lange Y, Steck TL. Active Cholesterol 20 Years On. Traffic. 21: 662-674. PMID 32930466 DOI: 10.1111/Tra.12762  0.484
2018 Steck TL, Lange Y. Transverse distribution of plasma membrane bilayer cholesterol: Picking sides. Traffic (Copenhagen, Denmark). 19: 750-760. PMID 29896788 DOI: 10.1111/Tra.12586  0.476
2016 Lange Y, Steck TL. Active membrane cholesterol as a physiological effector. Chemistry and Physics of Lipids. PMID 26874289 DOI: 10.1016/J.Chemphyslip.2016.02.003  0.457
2016 Gong Z, Kerr D, Tietjen GT, Michael Henderson J, Luoma AM, Bu W, Cao KD, Luke Hwang H, Steck TL, Lin B, Adams EJ, Lee KYC. Mechanism of TIM1, TIM3, and TIM4 Binding to Lipid Membranes Biophysical Journal. 110: 592a. DOI: 10.1016/J.Bpj.2015.11.3159  0.445
2015 Gong Z, Tietjen GT, Kerr DH, Henderson JM, Cao KD, Posner NA, Steck TL, Adams EJ, Lee KYC. Establishing the Synergy of Forces Governing TIM3 Binding to Lipid Membranes Biophysical Journal. 108: 255a. DOI: 10.1016/J.Bpj.2014.11.1412  0.446
2014 Lange Y, Ye J, Steck TL. Essentially all excess fibroblast cholesterol moves from plasma membranes to intracellular compartments. Plos One. 9: e98482. PMID 25014655 DOI: 10.1371/Journal.Pone.0098482  0.495
2014 Tietjen GT, Gong Z, Chen CH, Vargas E, Crooks JE, Cao KD, Heffern CT, Henderson JM, Meron M, Lin B, Roux B, Schlossman ML, Steck TL, Lee KY, Adams EJ. Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4. Proceedings of the National Academy of Sciences of the United States of America. 111: E1463-72. PMID 24706780 DOI: 10.1016/J.Bpj.2013.11.149  0.421
2014 Lange Y, Ye J, Steck TL. Correction: Essentially all excess fibroblast cholesterol moves from plasma membranes to intracellular compartments (PLoS ONE (2014) 9, 7 (e98482) DOI: 10.1371/journal.pone.0098482) Plos One. 9. DOI: 10.1371/journal.pone.0106160  0.312
2013 Lange Y, Tabei SM, Ye J, Steck TL. Stability and stoichiometry of bilayer phospholipid-cholesterol complexes: relationship to cellular sterol distribution and homeostasis. Biochemistry. 52: 6950-9. PMID 24000774 DOI: 10.1021/Bi400862Q  0.416
2012 Steck TL, Lange Y. How slow is the transbilayer diffusion (flip-flop) of cholesterol? Biophysical Journal. 102: 945-6; author reply . PMID 22385866 DOI: 10.1016/J.Bpj.2011.10.059  0.393
2012 Lange Y, Ye J, Steck TL. Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. Plos One. 7: e30051. PMID 22276143 DOI: 10.1371/Journal.Pone.0030051  0.456
2010 Steck TL, Lange Y. Cell cholesterol homeostasis: mediation by active cholesterol. Trends in Cell Biology. 20: 680-7. PMID 20843692 DOI: 10.1016/J.Tcb.2010.08.007  0.448
2009 Lange Y, Ye J, Duban ME, Steck TL. Activation of membrane cholesterol by 63 amphipaths. Biochemistry. 48: 8505-15. PMID 19655814 DOI: 10.1021/Bi900951R  0.701
2009 Lange Y, Steck TL, Ye J, Lanier MH, Molugu V, Ory D. Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol. Journal of Lipid Research. 50: 1881-8. PMID 19401598 DOI: 10.1194/Jlr.M900116-Jlr200  0.415
2008 Lange Y, Steck TL. Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol. Progress in Lipid Research. 47: 319-32. PMID 18423408 DOI: 10.1016/J.Plipres.2008.03.001  0.493
2008 Lange Y, Ory DS, Ye J, Lanier MH, Hsu FF, Steck TL. Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. The Journal of Biological Chemistry. 283: 1445-55. PMID 18024962 DOI: 10.1074/Jbc.M706967200  0.396
2007 Ratajczak MK, Ko YT, Lange Y, Steck TL, Lee KY. Cholesterol displacement from membrane phospholipids by hexadecanol. Biophysical Journal. 93: 2038-47. PMID 17526582 DOI: 10.1529/Biophysj.107.109553  0.413
2007 Lange Y, Ye J, Steck TL. Scrambling of phospholipids activates red cell membrane cholesterol. Biochemistry. 46: 2233-8. PMID 17269796 DOI: 10.1021/Bi6023397  0.481
2005 Lange Y, Ye J, Steck TL. Activation of membrane cholesterol by displacement from phospholipids. The Journal of Biological Chemistry. 280: 36126-31. PMID 16129675 DOI: 10.1074/Jbc.M507149200  0.499
2004 Lange Y, Ye J, Steck TL. How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids. Proceedings of the National Academy of Sciences of the United States of America. 101: 11664-7. PMID 15289597 DOI: 10.1073/Pnas.0404766101  0.483
2002 Steck TL, Lange Y. SCAP, an ER sensor that regulates cell cholesterol. Developmental Cell. 3: 306-8. PMID 12361593 DOI: 10.1016/S1534-5807(02)00263-0  0.317
2002 Steck TL, Ye J, Lange Y. Probing red cell membrane cholesterol movement with cyclodextrin. Biophysical Journal. 83: 2118-25. PMID 12324429 DOI: 10.1016/S0006-3495(02)73972-6  0.461
2002 Lange Y, Ye J, Rigney M, Steck TL. Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts. Journal of Lipid Research. 43: 198-204. PMID 11861661  0.361
2002 Lange Y, Ye J, Steck TL. Effect of protein kinase C on endoplasmic reticulum cholesterol. Biochemical and Biophysical Research Communications. 290: 488-93. PMID 11779197 DOI: 10.1006/Bbrc.2001.6156  0.412
2000 Lange Y, Ye J, Rigney M, Steck T. Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles. The Journal of Biological Chemistry. 275: 17468-75. PMID 10751394 DOI: 10.1074/Jbc.M000875200  0.378
1999 Lange Y, Ye J, Rigney M, Steck TL. Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. Journal of Lipid Research. 40: 2264-70. PMID 10588952  0.362
1998 Lange Y, Steck TL. Four cholesterol-sensing proteins. Current Opinion in Structural Biology. 8: 435-9. PMID 9729733 DOI: 10.1016/S0959-440X(98)80119-X  0.302
1998 Lange Y, Ye J, Steck TL. Circulation of cholesterol between lysosomes and the plasma membrane. The Journal of Biological Chemistry. 273: 18915-22. PMID 9668068 DOI: 10.1074/Jbc.273.30.18915  0.478
1997 Sarkar S, Steck TL. An NADH-dependent disulfide reductase activity in the endoplasmic reticulum of Dictyostelium discoideum. Biochemical and Biophysical Research Communications. 234: 313-5. PMID 9177266 DOI: 10.1006/Bbrc.1997.6631  0.401
1997 Lange Y, Steck TL. Quantitation of the pool of cholesterol associated with acyl-CoA:cholesterol acyltransferase in human fibroblasts. The Journal of Biological Chemistry. 272: 13103-8. PMID 9148923 DOI: 10.1074/Jbc.272.20.13103  0.426
1996 Lange Y, Steck TL. The role of intracellular cholesterol transport in cholesterol homeostasis. Trends in Cell Biology. 6: 205-8. PMID 15157456 DOI: 10.1016/0962-8924(96)20016-9  0.491
1996 Khodadad JK, Waugh RE, Podolski JL, Josephs R, Steck TL. Remodeling the shape of the skeleton in the intact red cell. Biophysical Journal. 70: 1036-44. PMID 8789122 DOI: 10.1016/S0006-3495(96)79649-2  0.46
1994 Nolta KV, Steck TL. Isolation and initial characterization of the bipartite contractile vacuole complex from Dictyostelium discoideum. The Journal of Biological Chemistry. 269: 2225-33. PMID 8294479  0.321
1994 Nolta KV, Rodriguez-Paris JM, Steck TL. Analysis of successive endocytic compartments isolated from Dictyostelium discoideum by magnetic fractionation. Biochimica Et Biophysica Acta. 1224: 237-46. PMID 7981238 DOI: 10.1016/0167-4889(94)90196-1  0.394
1994 Lange Y, Steck TL. Cholesterol homeostasis. Modulation by amphiphiles. The Journal of Biological Chemistry. 269: 29371-4. PMID 7961912  0.38
1994 Temesvari L, Rodriguez-Paris J, Bush J, Steck TL, Cardelli J. Characterization of lysosomal membrane proteins of Dictyostelium discoideum. A complex population of acidic integral membrane glycoproteins, Rab GTP-binding proteins and vacuolar ATPase subunits. The Journal of Biological Chemistry. 269: 25719-27. PMID 7929276  0.341
1994 Steck TL, Lavasa M. A general method for plasma membrane isolation by colloidal gold density shift. Analytical Biochemistry. 223: 47-50. PMID 7695101 DOI: 10.1006/Abio.1994.1544  0.465
1993 Lange Y, Strebel F, Steck TL. Role of the plasma membrane in cholesterol esterification in rat hepatoma cells. The Journal of Biological Chemistry. 268: 13838-43. PMID 8314752  0.377
1991 Lange Y, Echevarria F, Steck TL. Movement of zymosterol, a precursor of cholesterol, among three membranes in human fibroblasts. The Journal of Biological Chemistry. 266: 21439-43. PMID 1939176  0.381
1989 Lange Y, Swaisgood MH, Ramos BV, Steck TL. Plasma membranes contain half the phospholipid and 90% of the cholesterol and sphingomyelin in cultured human fibroblasts. The Journal of Biological Chemistry. 264: 3786-93. PMID 2917977  0.407
1989 Waseem A, Steck TL. Protein associations with band 3 at cytoplasmic surface of human erythrocyte membrane. Methods in Enzymology. 173: 513-9. PMID 2779438 DOI: 10.1016/S0076-6879(89)73035-4  0.317
1989 Lieber MR, Steck TL. Hemolytic holes in human erythrocyte membrane ghosts. Methods in Enzymology. 173: 356-67. PMID 2779432 DOI: 10.1016/S0076-6879(89)73023-8  0.354
1989 Khodadad JK, Weinstein RS, Marsh LW, Steck TL. Shape determinants of McLeod acanthocytes. The Journal of Membrane Biology. 107: 213-8. PMID 2716045 DOI: 10.1007/Bf01871936  0.36
1989 Vertessy BG, Steck TL. Elasticity of the human red cell membrane skeleton. Effects of temperature and denaturants. Biophysical Journal. 55: 255-62. PMID 2713438 DOI: 10.1016/S0006-3495(89)82800-0  0.391
1989 Rogalski AA, Steck TL, Waseem A. Association of glyceraldehyde-3-phosphate dehydrogenase with the plasma membrane of the intact human red blood cell. The Journal of Biological Chemistry. 264: 6438-46. PMID 2649501  0.31
1989 Padh H, Lavasa M, Steck TL. Characterization of a vacuolar proton ATPase in Dictyostelium discoideum. Biochimica Et Biophysica Acta. 982: 271-8. PMID 2526657 DOI: 10.1016/0005-2736(89)90064-3  0.405
1989 Padh H, Lavasa M, Steck TL. Prelysosomal acidic vacuoles in Dictyostelium discoideum. The Journal of Cell Biology. 108: 865-74. PMID 2466039 DOI: 10.1083/Jcb.108.3.865  0.39
1988 Steck TL, Kezdy FJ, Lange Y. An activation-collision mechanism for cholesterol transfer between membranes. The Journal of Biological Chemistry. 263: 13023-31. PMID 3417649  0.306
1986 Shen BW, Josephs R, Steck TL. Ultrastructure of the intact skeleton of the human erythrocyte membrane. The Journal of Cell Biology. 102: 997-1006. PMID 2936753 DOI: 10.1083/Jcb.102.3.997  0.405
1985 Jenkins JD, Kezdy FJ, Steck TL. Mode of interaction of phosphofructokinase with the erythrocyte membrane. The Journal of Biological Chemistry. 260: 10426-33. PMID 3161879  0.327
1985 Lange Y, Steck TL. Cholesterol-rich intracellular membranes: a precursor to the plasma membrane. The Journal of Biological Chemistry. 260: 15592-7. PMID 2999124  0.411
1984 Lieber MR, Lange Y, Weinstein RS, Steck TL. Interaction of chlorpromazine with the human erythrocyte membrane. The Journal of Biological Chemistry. 259: 9225-34. PMID 6746647  0.341
1984 Lange Y, Steck TL. Mechanism of red blood cell acanthocytosis and echinocytosis in vivo. The Journal of Membrane Biology. 77: 153-9. PMID 6708089 DOI: 10.1007/Bf01925863  0.461
1984 Shen BW, Josephs R, Steck TL. Ultrastructure of unit fragments of the skeleton of the human erythrocyte membrane. The Journal of Cell Biology. 99: 810-21. PMID 6470041 DOI: 10.1083/Jcb.99.3.810  0.311
1984 Lange Y, Matthies H, Steck TL. Cholesterol oxidase susceptibility of the red cell membrane Bba - Biomembranes. 769: 551-562. PMID 6421320 DOI: 10.1016/0005-2736(84)90053-1  0.472
1984 Jenkins JD, Madden DP, Steck TL. Association of phosphofructokinase and aldolase with the membrane of the intact erythrocyte. The Journal of Biological Chemistry. 259: 9374-8. PMID 6235228  0.359
1982 Lange Y, Gough A, Steck TL. Role of the bilayer in the shape of the isolated erythrocyte membrane. The Journal of Membrane Biology. 69: 113-23. PMID 7131536 DOI: 10.1007/Bf01872271  0.477
1982 Lieber MR, Steck TL. A description of the holes in human erythrocyte membrane ghosts. The Journal of Biological Chemistry. 257: 11651-9. PMID 7118901  0.313
1982 Lange Y, Hadesman RA, Steck TL. Role of the reticulum in the stability and shape of the isolated human erythrocyte membrane. The Journal of Cell Biology. 92: 714-21. PMID 7085754 DOI: 10.1083/Jcb.92.3.714  0.447
1982 Tsai IH, Murthy SN, Steck TL. Effect of red cell membrane binding on the catalytic activity of glyceraldehyde-3-phosphate dehydrogenase. The Journal of Biological Chemistry. 257: 1438-42. PMID 7056725  0.312
1981 Lange Y, Dolde J, Steck TL. The rate of transmembrane movement of cholesterol in the human erythrocyte. The Journal of Biological Chemistry. 256: 5321-3. PMID 7240138  0.348
1980 Lange Y, Cutler HB, Steck TL. The effect of cholesterol and other intercalated amphipaths on the contour and stability of the isolated red cell membrane. The Journal of Biological Chemistry. 255: 9331-7. PMID 7410427  0.408
1980 Kliman HJ, Steck TL. Association of glyceraldehyde-3-phosphate dehydrogenase with the human red cell membrane. A kinetic analysis. The Journal of Biological Chemistry. 255: 6314-21. PMID 7391020  0.305
1980 England BJ, Gunn RB, Steck TL. An immunological study of band 3, the anion transport protein of the human red blood cell membrane. Biochimica Et Biophysica Acta. 623: 171-82. PMID 6769498 DOI: 10.1016/0005-2795(80)90019-7  0.381
1978 Weinstein RS, Khodadad JK, Steck TL. Fine structure of the band 3 protein in human red cell membranes: freeze-fracture studies. Journal of Supramolecular Structure. 8: 325-35. PMID 723268 DOI: 10.1002/Jss.400080310  0.423
1978 Weinstein RS, Khodadad JK, Steck TL. Ultrastructural characterization of proteins at the natural surfaces of the red cell membrane. Progress in Clinical and Biological Research. 21: 413-29. PMID 662900  0.309
1978 Steck TL, Koziarz JJ, Singh MK, Reddy G, Köhler H. Preparation and analysis of seven major, topographically defined fragments of band 3, the predominant transmembrane polypeptide of human erythrocyte membranes. Biochemistry. 17: 1216-22. PMID 656385 DOI: 10.1021/Bi00600A013  0.419
1978 Steck TL. The band 3 protein of the human red cell membrane: a review. Journal of Supramolecular Structure. 8: 311-24. PMID 364194 DOI: 10.1002/Jss.400080309  0.438
1977 Hainfeld JF, Steck TL. The sub-membrane reticulum of the human erythrocyte: a scanning electron microscope study. Journal of Supramolecular Structure. 6: 301-11. PMID 592817 DOI: 10.1002/Jss.400060303  0.392
1977 Rice WR, Steck TL. Pyruvate transport into inside-out vesicles isolated from human erythrocyte membranes. Biochimica Et Biophysica Acta. 468: 305-17. PMID 195608 DOI: 10.1016/0005-2736(77)90123-7  0.438
1977 Strapazon E, Steck TL. Interaction of the aldolase and the membrane of human erythrocytes. Biochemistry. 16: 2966-71. PMID 18166 DOI: 10.1021/Bi00632A025  0.459
1977 Steck TL. The Molecular Biology of Cell Membranes. Peter J. Quinn The Quarterly Review of Biology. 52: 403-404. DOI: 10.1086/410160  0.303
1976 Steck TL, Wackman N, Tarlov AR. The exchange of erythrocyte membrane phospholipids with rat liver extracts in vitro. Journal of Supramolecular Structure. 4: 169-80. PMID 1263508 DOI: 10.1002/Jss.400040204  0.403
1976 Holzwarth G, Yu J, Steck TL. Heterogeneity in the conformation of different protein fractions from the human erythrocyte membrane. Journal of Supramolecular Structure. 4: 161-8. PMID 1263507 DOI: 10.1002/Jss.400040203  0.39
1976 Strapazon E, Steck TL. Binding of rabbit muscle aldolase to band 3, the predominant polypeptide of the human erythrocyte membrane. Biochemistry. 15: 1421-4. PMID 1259946 DOI: 10.1021/Bi00652A011  0.455
1976 Steck TL, Ramos B, Strapazon E. Proteolytic dissection of band 3, the predominant transmembrane polypeptide of the human erythrocyte membrane. Biochemistry. 15: 1153-61. PMID 1252433 DOI: 10.1021/Bi00650A030  0.434
1976 Rice WR, Steck TL. Pyruvate flux into resealed ghosts from human erythrocytes. Biochimica Et Biophysica Acta. 433: 39-53. PMID 4147 DOI: 10.1016/0005-2736(76)90176-0  0.402
1975 Lorand L, Shishido R, Parameswaran KN, Steck TL. Modification of human erythrocyte ghosts with transglutaminase. Biochemical and Biophysical Research Communications. 67: 1158-66. PMID 1028 DOI: 10.1016/0006-291X(75)90795-0  0.368
1974 Steck TL, Dawson C. Topographical distribution of complex carbohydrates in the erythrocyte membrane Journal of Biological Chemistry. 249: 2135-2142. PMID 4818830  0.332
1974 Steck TL. The organization of proteins in the human red blood cell membrane. A review. The Journal of Cell Biology. 62: 1-19. PMID 4600883 DOI: 10.1083/Jcb.62.1.1  0.386
1974 Steck TL, Kant JA. [16] Preparation of impermeable ghosts and inside-out vesicles from human erythrocyte membranes Methods in Enzymology. 31: 172-180. PMID 4370662 DOI: 10.1016/0076-6879(74)31019-1  0.438
1973 Yu J, Fischman DA, Steck TL. Selective solubilization of proteins and phospholipids from red blood cell membranes by nonionic detergents Journal of Supramolecular and Cellular Biochemistry. 1: 233-248. PMID 4804838 DOI: 10.1002/Jss.400010308  0.483
1973 Steck TL, Yu J. Selective solubilization of proteins from red blood cell membranes by protein perturbants Journal of Supramolecular and Cellular Biochemistry. 1: 220-232. PMID 4804837 DOI: 10.1002/Jss.400010307  0.48
1973 Kant JA, Steck TL. Adenosine 3′,5′ monophosphate binds only to the inner surface of human erythrocyte membranes Biochemical and Biophysical Research Communications. 54: 116-122. PMID 4354937 DOI: 10.1016/0006-291X(73)90896-6  0.436
1973 Kant JA, Steck TL. Specificity in the association of glyceraldehyde 3 phosphate dehydrogenase with isolated human erythrocyte membranes Journal of Biological Chemistry. 248: 8457-8464. PMID 4148672  0.341
1972 Steck TL. Selective solubilization of red blood cell membrane proteins with guanidine hydrochloride Bba - Biomembranes. 255: 553-556. PMID 5057932 DOI: 10.1016/0005-2736(72)90158-7  0.448
1972 Steck TL. Cross-linking the major proteins of the isolated erythrocyte membrane Journal of Molecular Biology. 66. PMID 5038456 DOI: 10.1016/0022-2836(72)90481-0  0.418
1972 Kant JA, Steck TL. Cation-impermeable inside-out and right-side-out vesicles from human erythrocyte membranes Nature: New Biology. 240: 26-28. PMID 4508297 DOI: 10.1038/Newbio240026A0  0.441
1971 Fairbanks G, Steck TL, Wallach DFH. Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane Biochemistry. 10: 2606-2617. PMID 4326772 DOI: 10.1021/Bi00789A030  0.418
1971 Steck TL, Fairbanks G, Wallach DFH. Disposition of the major proteins in the isolated erythrocyte membrane. Proteolytic dissection Biochemistry. 10: 2617-2624. PMID 4104271 DOI: 10.1021/Bi00789A031  0.462
1970 Steck TL, Straus JH, Wallach DFH. A model for the behavior of vesicles in density gradients: Implications for fractionation Bba - Biomembranes. 203: 385-393. PMID 5523738 DOI: 10.1016/0005-2736(70)90179-3  0.369
1970 Steck TL, Weinstein RS, Straus JH, Wallach DFH. Inside-out red cell membrane vesicles: Preparation and purification Science. 168: 255-257. PMID 5418644 DOI: 10.1126/Science.168.3928.255  0.461
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