Paul J. Lucassen - Publications

SILS-CNS University of Amsterdam, Amsterdam, Netherlands 
Neurogenesis, stress, depression, Alzheimer

229 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kaiser A, Reneman L, Lucassen PJ, de Vries TJ, Schrantee A, Kaag AM. Targeting working memory to modify emotional reactivity in adult attention deficit hyperactivity disorder: a functional magnetic resonance imaging study. Brain Imaging and Behavior. PMID 34524649 DOI: 10.1007/s11682-021-00532-6  1
2021 Lesuis SL, Brosens N, Immerzeel N, van der Loo RJ, Mitrić M, Bielefeld P, Fitzsimons CP, Lucassen PJ, Kushner SA, van den Oever MC, Krugers HJ. Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population. Biological Psychiatry. 90: 494-504. PMID 34503674 DOI: 10.1016/j.biopsych.2021.04.010  1
2021 Kotah JM, Hoeijmakers L, Nutma E, Lucassen PJ, Korosi A. Early-life stress does not alter spatial memory performance, hippocampal neurogenesis, neuroinflammation, or telomere length in 20-month-old male mice. Neurobiology of Stress. 15: 100379. PMID 34430678 DOI: 10.1016/j.ynstr.2021.100379  1
2021 Du Preez A, Lefèvre-Arbogast S, Houghton V, de Lucia C, Low DY, Helmer C, Féart C, Delcourt C, Proust-Lima C, Pallàs M, Ruigrok SR, Altendorfer B, González-Domínguez R, Sánchez-Pla A, Urpi-Sardà M, ... ... Lucassen PJ, et al. The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34402599 DOI: 10.1002/alz.12428  1
2021 Ruigrok SR, Stöberl N, Yam KY, de Lucia C, Lucassen PJ, Thuret S, Korosi A. Modulation of the Hypothalamic Nutrient Sensing Pathways by Sex and Early-Life Stress. Frontiers in Neuroscience. 15: 695367. PMID 34366778 DOI: 10.3389/fnins.2021.695367  1
2021 Homberg JR, Adan RAH, Alenina N, Asiminas A, Bader M, Beckers T, Begg DP, Blokland A, Burger ME, van Dijk G, Eisel ULM, Elgersma Y, Englitz B, Fernandez-Ruiz A, Fitzsimons CP, ... ... Lucassen PJ, et al. The continued need for animals to advance brain research. Neuron. 109: 2374-2379. PMID 34352213 DOI: 10.1016/j.neuron.2021.07.015  1
2021 Swaab DF, Buijs RM, Kreier F, Lucassen PJ, Salehi A. Preface. Handbook of Clinical Neurology. 182: ix-xi. PMID 34266616 DOI: 10.1016/B978-0-12-819973-2.09997-4  1
2021 Swaab DF, Buijs RM, Kreier F, Lucassen PJ, Salehi A. Introduction: The human hypothalamus and neuropsychiatric disorders. Handbook of Clinical Neurology. 182: 1-5. PMID 34266586 DOI: 10.1016/B978-0-12-819973-2.00001-0  1
2021 Swaab DF, Buijs RM, Lucassen PJ, Salehi A, Kreier F. Introduction: The human hypothalamus and neuroendocrine disorders. Handbook of Clinical Neurology. 181: 1-5. PMID 34238450 DOI: 10.1016/B978-0-12-820683-6.00001-4  1
2021 Swaab DF, Kreier F, Lucassen PJ, Salehi A, Buijs RM. Preface. Handbook of Clinical Neurology. 179: ix-xi. PMID 34225988 DOI: 10.1016/B978-0-12-819975-6.09987-8  1
2021 Swaab DF, Buijs RM, Kreier F, Lucassen PJ, Salehi A. Introduction: The anterior hypothalamus. Handbook of Clinical Neurology. 179: 3-5. PMID 34225970 DOI: 10.1016/B978-0-12-819975-6.00014-5  1
2021 Sharif A, Fitzsimons CP, Lucassen PJ. Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology. Handbook of Clinical Neurology. 179: 125-140. PMID 34225958 DOI: 10.1016/B978-0-12-819975-6.00006-6  1
2021 Swaab DF, Kreier F, Lucassen PJ, Salehi A, Buijs RM. Introduction: The middle and posterior hypothalamus. Handbook of Clinical Neurology. 180: 1-4. PMID 34225923 DOI: 10.1016/B978-0-12-820107-7.00001-X  1
2021 Sanguino-Gómez J, Buurstede JC, Abiega O, Fitzsimons CP, Lucassen PJ, Eggen BJ, Lesuis SL, Meijer OC, Krugers HJ. An emerging role for microglia in stress-effects on memory. The European Journal of Neuroscience. PMID 33724565 DOI: 10.1111/ejn.15188  1
2021 Lefèvre-Arbogast S, Hejblum BP, Helmer C, Klose C, Manach C, Low DY, Urpi-Sarda M, Andres-Lacueva C, González-Domínguez R, Aigner L, Altendorfer B, Lucassen PJ, Ruigrok SR, De Lucia C, Du Preez A, et al. Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study. Ebiomedicine. 64: 103216. PMID 33508744 DOI: 10.1016/j.ebiom.2021.103216  1
2021 Ruigrok SR, Abbink MR, Geertsema J, Kuindersma JE, Stöberl N, van der Beek EM, Lucassen PJ, Schipper L, Korosi A. Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers. Nutrients. 13. PMID 33498469 DOI: 10.3390/nu13020288  1
2021 Bielefeld P, Abbink MR, Davidson AR, Reijner N, Abiega O, Lucassen PJ, Korosi A, Fitzsimons CP. Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus. Stress (Amsterdam, Netherlands). 1-15. PMID 33494651 DOI: 10.1080/10253890.2021.1879787  1
2020 Hu P, Maita I, Phan ML, Gu E, Kwok C, Dieterich A, Gergues MM, Yohn CN, Wang Y, Zhou JN, Qi XR, Swaab DF, Pang ZP, Lucassen PJ, Roepke TA, et al. Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis. Translational Psychiatry. 10: 396. PMID 33177511 DOI: 10.1038/s41398-020-01070-3  1
2020 Genzel L, Adan R, Berns A, van den Beucken JJJP, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, van Dam AM, Deen PMT, van Dijk KW, ... ... Lucassen PJ, et al. How the COVID-19 pandemic highlights the necessity of animal research. Current Biology : Cb. 30: 4328. PMID 33142090 DOI: 10.1016/j.cub.2020.10.033  1
2020 Houghton V, Du Preez A, Lefèvre-Arbogast S, de Lucia C, Low DY, Urpi-Sarda M, Ruigrok SR, Altendorfer B, González-Domínguez R, Andres-Lacueva C, Aigner L, Lucassen PJ, Korosi A, Samieri C, Manach C, et al. Caffeine Compromises Proliferation of Human Hippocampal Progenitor Cells. Frontiers in Cell and Developmental Biology. 8: 806. PMID 33015033 DOI: 10.3389/Fcell.2020.00806  1
2020 Genzel L, Adan R, Berns A, van den Beucken J, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, Dam AV, Deen PMT, van Dijk KW, ... ... Lucassen PJ, et al. How the COVID-19 pandemic highlights the necessity of animal research. Current Biology : Cb. 30: R1014-R1018. PMID 32961149 DOI: 10.1016/J.Cub.2020.08.030  1
2020 D'Alessio L, Mesarosova L, Anink JJ, Kochen S, Solís P, Oddo S, Konopka H, Iyer AM, Mühlebner A, Lucassen PJ, Aronica E, van Vliet EA. Reduced expression of the glucocorticoid receptor in the hippocampus of patients with drug-resistant temporal lobe epilepsy and comorbid depression. Epilepsia. PMID 32652588 DOI: 10.1111/Epi.16598  1
2020 Solleveld MM, Schrantee A, Homberg JR, Lucassen PJ, Reneman L. The influence of age-of-onset of antidepressant use on the acute CBF response to a citalopram challenge; a pharmacological MRI study. Psychiatry Research. Neuroimaging. 303: 111126. PMID 32592855 DOI: 10.1016/J.Pscychresns.2020.111126  1
2020 Zhang L, Verwer RWH, Lucassen PJ, Huitinga I, Swaab DF. Sex difference in glia gene expression in the dorsolateral prefrontal cortex in bipolar disorder: Relation to psychotic features. Journal of Psychiatric Research. 125: 66-74. PMID 32208195 DOI: 10.1016/J.Jpsychires.2020.03.003  1
2020 Abbink MR, Kotah JM, Hoeijmakers L, Mak A, Yvon-Durocher G, van der Gaag B, Lucassen PJ, Korosi A. Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure. Journal of Neuroinflammation. 17: 91. PMID 32197653 DOI: 10.1186/S12974-020-01762-Z  1
2020 Solleveld MM, Schrantee A, Baek HK, Bottelier MA, Tamminga HGH, Bouziane C, Stoffelsen R, Lucassen PJ, Van Someren EJW, Rijsman RM, Reneman L. Effects of 16 Weeks of Methylphenidate Treatment on Actigraph-Assessed Sleep Measures in Medication-Naive Children With ADHD. Frontiers in Psychiatry. 11: 82. PMID 32184743 DOI: 10.3389/Fpsyt.2020.00082  1
2020 Abbink MR, Schipper L, Naninck EFG, de Vos CMH, Meier R, van der Beek EM, Lucassen PJ, Korosi A. The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes. Nutrients. 12. PMID 32098348 DOI: 10.3390/Nu12020570  1
2020 Hu P, van Dam AM, Wang Y, Lucassen PJ, Zhou JN. Retinoic Acid and Depressive Disorders: Evidence and Possible Neurobiological Mechanisms. Neuroscience and Biobehavioral Reviews. PMID 32070693 DOI: 10.1016/J.Neubiorev.2020.02.013  1
2020 Hu P, Liu J, Maita I, Kwok C, Gu E, Gergues MM, Kelada F, Phan M, Zhou JN, Swaab DF, Pang Z, Lucassen PJ, Roepke TA, Samuels BA. Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32054675 DOI: 10.1523/Jneurosci.2410-19.2020  1
2020 Lucassen P, Kempermann G. Decision letter: Phylogenetic variation in cortical layer II immature neuron reservoir of mammals Elife. DOI: 10.7554/Elife.55456.Sa1  1
2020 Krugers H, Lesuis S, Xiong H, Loo Rvd, Kushner S, Lucassen P, oever MVd. Glucocorticoids Promote Fear Generalization by Altering Memory Encoding Neuronal Ensembles Biological Psychiatry. 87. DOI: 10.1016/J.Biopsych.2020.02.101  1
2019 Lucassen PJ, van Dam AM, Kandel P, Bielefeld P, Korosi A, Fitzsimons CP, Maletic-Savatic M. The orphan nuclear receptor TLX: an emerging master regulator of cross-talk between microglia and neural precursor cells. Health Psychology and Behavioral Medicine. 3: NS20180208. PMID 32271856 DOI: 10.1042/NS20180208  1
2019 Lucassen PJ, Fitzsimons CP, Salta E, Maletic-Savatic M. Adult neurogenesis, human after all (again): classic, optimized, and future approaches. Behavioural Brain Research. 112458. PMID 31899214 DOI: 10.1016/J.Bbr.2019.112458  1
2019 Zhang L, Verwer RWH, Lucassen PJ, Huitinga I, Swaab DF. Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide. Journal of Psychiatric Research. 121: 31-38. PMID 31739114 DOI: 10.1016/J.Jpsychires.2019.11.002  1
2019 Lesuis SL, Timmermans W, Lucassen PJ, Hoogenraad CC, Krugers HJ. Glucocorticoid and β-adrenergic regulation of hippocampal dendritic spines. Journal of Neuroendocrinology. PMID 31715030 DOI: 10.1111/Jne.12811  1
2019 Kompier NF, Keysers C, Gazzola V, Lucassen PJ, Krugers HJ. Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators. Frontiers in Behavioral Neuroscience. 13: 143. PMID 31404254 DOI: 10.3389/Fnbeh.2019.00143  1
2019 Lesuis SL, Lucassen PJ, Krugers HJ. Early life stress amplifies fear responses and hippocampal synaptic potentiation in the APPswe/PS1dE9 Alzheimer mouse model. Neuroscience. PMID 31302265 DOI: 10.1016/J.Neuroscience.2019.07.012  1
2019 Zhao J, Lucassen PJ, Swaab DF. Suicide Is a Confounder in Postmortem Studies on Depression. Biological Psychiatry. PMID 31227102 DOI: 10.1016/J.Biopsych.2019.04.015  1
2019 Schouten M, Bielefeld P, Garcia-Corzo L, Passchier EMJ, Gradari S, Jungenitz T, Pons-Espinal M, Gebara E, Martín-Suárez S, Lucassen PJ, De Vries HE, Trejo JL, Schwarzacher SW, De Pietri Tonelli D, Toni N, et al. Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain. Molecular Psychiatry. PMID 31222184 DOI: 10.1038/S41380-019-0440-2  1
2019 Low DY, Lefèvre-Arbogast S, González-Domínguez R, Urpi-Sarda M, Micheau P, Petera M, Centeno D, Durand S, Pujos-Guillot E, Korosi A, Lucassen PJ, Aigner L, Proust-Lima C, Hejblum BP, Helmer C, et al. Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort. Molecular Nutrition & Food Research. e1900177. PMID 31218777 DOI: 10.1002/Mnfr.201900177  1
2019 Bielefeld P, Durá I, Danielewicz J, Lucassen PJ, Baekelandt V, Abrous DN, Encinas JM, Fitzsimons CP. Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies. Behavioural Brain Research. 372: 112032. PMID 31199935 DOI: 10.1016/J.Bbr.2019.112032  1
2019 Schrantee A, Solleveld MM, Schwantje H, Bruin WB, Mutsaerts HM, Adriaanse SM, Lucassen P, Booij J, Reneman L. Dose-dependent effects of the selective serotonin reuptake inhibitor citalopram: A combined SPECT and phMRI study. Journal of Psychopharmacology (Oxford, England). 269881119836229. PMID 30887865 DOI: 10.1177/0269881119836229  1
2019 Bielefeld P, Schouten M, Meijer GM, Breuk MJ, Geijtenbeek K, Karayel S, Tiaglik A, Vuuregge AH, Willems RAL, Witkamp D, Lucassen PJ, Encinas JM, Fitzsimons CP. Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures. Frontiers in Molecular Neuroscience. 12: 31. PMID 30837840 DOI: 10.3389/Fnmol.2019.00031  1
2019 Lesuis SL, Kaplick P, Lucassen PJ, Krugers HJ. Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice. Neuropharmacology. PMID 30794835 DOI: 10.1016/J.Neuropharm.2019.02.023  1
2019 Yam KY, Schipper L, Reemst K, Ruigrok SR, Abbink MR, Hoeijmakers L, Naninck EFG, Zarekiani P, Oosting A, Van der Beek EM, Lucassen PJ, Korosi A. Increasing availability of ω-3 fatty acid in the early-life diet prevents the early-life stress-induced cognitive impairments without affecting metabolic alterations. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802297R. PMID 30673509 DOI: 10.1096/Fj.201802297R  1
2019 Lesuis SL, Lucassen PJ, Krugers HJ. Early life stress impairs fear conditioning memory and synaptic plasticity; a potential role for GluN2B. Neuropharmacology. PMID 30641077 DOI: 10.1016/J.Neuropharm.2019.01.010  1
2019 Lucassen PJ, Toni N, Kempermann G, Frisen J, Gage FH, Swaab DF. Limits to human neurogenesis-really? Molecular Psychiatry. PMID 30617274 DOI: 10.1038/S41380-018-0337-5  1
2019 Lefèvre-Arbogast S, Low DY, González-Domínguez R, Urpi-Sarda M, Micheau P, Petera M, Centeno D, Durand S, Pujos-Guillot E, Korosi A, Lucassen PJ, Aigner L, Proust-Lima C, Hejblum BP, Helmer C, et al. Untargeted Metabolomics In A Prospective Cohort To Identify Diet-Related Metabolites Associated With Age-Related Cognitive Decline Alzheimers & Dementia. 15: 234. DOI: 10.1016/J.Jalz.2019.06.036  1
2019 Krugers H, Lesuis SL, Lucassen PJ. S.21.04 Early life experiences, amyloid pathology and cognitive function European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.961  1
2019 Ruigrok S, Yam KY, Abbink MR, Kroon J, Fleur SEL, Lucassen PJ, Korosi A. Programming of metabolic functions by early-life stress: Relevance for vulnerability to obesity European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.776  1
2019 Reemst K, Hoeijmakers L, Yam KY, Beek EMVd, Schipper L, Oosting A, Dam AV, Lucassen PJ, Korosi A. Early-life stress affects microglia, possible modulation by dietary fatty acids European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.772  1
2018 Gao S, Zhang T, Jin L, Liang D, Fan G, Song Y, Lucassen PJ, Yu R, Swaab DF. CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model. Cerebral Cortex (New York, N.Y. : 1991). PMID 30307500 DOI: 10.1093/Cercor/Bhy254  1
2018 Lesuis SL, Hoeijmakers L, Korosi A, de Rooij SR, Swaab DF, Kessels HW, Lucassen PJ, Krugers HJ. Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimer's Research & Therapy. 10: 95. PMID 30227888 DOI: 10.1186/S13195-018-0422-7  1
2018 Lesuis SL, Catsburg LAE, Lucassen PJ, Krugers HJ. Effects of corticosterone on mild auditory fear conditioning and extinction; role of sex and training paradigm. Learning & Memory (Cold Spring Harbor, N.Y.). 25: 544-549. PMID 30224557 DOI: 10.1101/Lm.047811.118  1
2018 Meerhoff GF, Vester SM, Hesseling P, Klaassen SD, Cornelissen AS, Lucassen PJ, Joosen MJA. Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar. Neurotoxicology. 68: 167-176. PMID 30130561 DOI: 10.1016/J.Neuro.2018.08.005  1
2018 Motta-Teixeira LC, Machado-Nils AV, Battagello DS, Diniz GB, Andrade-Silva J, Silva-Junior S, Matos RA, do Amaral FG, Xavier GF, Bittencourt JC, Reiter RJ, Lucassen PJ, Korosi A, Cipolla-Neto J. The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior. Hormones and Behavior. PMID 30114430 DOI: 10.1016/J.Yhbeh.2018.08.006  1
2018 Schrantee A, Lucassen PJ, Booij J, Reneman L. Serotonin transporter occupancy by the SSRI citalopram predicts default-mode network connectivity. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 30082141 DOI: 10.1016/J.Euroneuro.2018.07.099  1
2018 Hoeijmakers L, Lesuis SL, Krugers H, Lucassen PJ, Korosi A. A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress. Neurobiology of Stress. 8: 172-185. PMID 29888312 DOI: 10.1016/J.Ynstr.2018.02.003  1
2018 Zhao J, Verwer RWH, Gao SF, Qi XR, Lucassen PJ, Kessels HW, Swaab DF. Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide. Journal of Psychiatric Research. 102: 261-274. PMID 29753198 DOI: 10.1016/J.Jpsychires.2018.04.020  1
2018 Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, ... ... Lucassen PJ, et al. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. PMID 29681514 DOI: 10.1016/J.Stem.2018.04.004  1
2018 Hoeijmakers L, Amelianchik A, Verhaag F, Kotah J, Lucassen PJ, Korosi A. Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice. Frontiers in Aging Neuroscience. 10: 61. PMID 29563870 DOI: 10.3389/Fnagi.2018.00061  1
2018 Lesuis SL, Weggen S, Baches S, Lucassen PJ, Krugers HJ. Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice. Translational Psychiatry. 8: 53. PMID 29491368 DOI: 10.1038/S41398-018-0101-2  1
2018 van Campen JS, Hessel EVS, Bohmbach K, Rizzi G, Lucassen PJ, Lakshmi Turimella S, Umeoka EHL, Meerhoff GF, Braun KPJ, de Graan PNE, Joëls M. Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice. Frontiers in Endocrinology. 9: 3. PMID 29434572 DOI: 10.3389/Fendo.2018.00003  1
2017 Hoeijmakers L, Meerhoff GF, de Vries JW, Ruigrok SR, van Dam AM, van Leuven F, Korosi A, Lucassen PJ. The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. Neurobiology of Aging. 61: 112-123. PMID 29059594 DOI: 10.1016/J.Neurobiolaging.2017.09.013  1
2017 Yam KY, Ruigrok SR, Ziko I, De Luca SN, Lucassen PJ, Spencer SJ, Korosi A. Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner. Psychoneuroendocrinology. 86: 73-77. PMID 28917185 DOI: 10.1016/J.Psyneuen.2017.09.006  1
2017 Solleveld MM, Schrantee A, Puts NAJ, Reneman L, Lucassen PJ. Age-dependent, lasting effects of methylphenidate on the GABAergic system of ADHD patients. Neuroimage. Clinical. 15: 812-818. PMID 28725548 DOI: 10.1016/J.Nicl.2017.06.003  1
2017 Walker CD, Bath KG, Joels M, Korosi A, Larauche M, Lucassen PJ, Morris MJ, Raineki C, Roth TL, Sullivan RM, Taché Y, Baram TZ. Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress (Amsterdam, Netherlands). 1-63. PMID 28617197 DOI: 10.1080/10253890.2017.1343296  1
2017 Lesuis SL, van Hoek BACE, Lucassen PJ, Krugers HJ. Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age. Neurobiology of Learning and Memory. 144: 27-35. PMID 28579367 DOI: 10.1016/J.Nlm.2017.05.016  1
2017 Bielefeld P, Schouten M, Lucassen PJ, Fitzsimons CP. Transcription factor oscillations in neural stem cells: Implications for accurate control of gene expression. Neurogenesis (Austin, Tex.). 4: e1262934. PMID 28321433 DOI: 10.1080/23262133.2016.1262934  1
2017 Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J, Freret T, Boulouard M, Desfosses E, Galineau L, Gozzi A, Dauphin F, Gsell W, ... ... Lucassen PJ, et al. Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. Plos One. 12: e0172776. PMID 28241065 DOI: 10.1371/Journal.Pone.0172776  1
2017 Krugers HJ, Arp JM, Xiong H, Kanatsou S, Lesuis SL, Korosi A, Joels M, Lucassen PJ. Early life adversity: Lasting consequences for emotional learning. Neurobiology of Stress. 6: 14-21. PMID 28229105 DOI: 10.1016/J.Ynstr.2016.11.005  1
2017 Yam KY, Naninck EFG, Abbink MR, Fleur SEl, Schipper L, Beukel JCvd, Grefhorst A, Oosting A, Beek EMvd, Lucassen PJ, Korosi A. Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice. Psychoneuroendocrinology. 77: 186-195. PMID 28088658 DOI: 10.1016/J.Psyneuen.2016.12.012  1
2017 Lucassen PJ, Lesuis SL, Weggen S, Baches S, Krugers HJ. Early Life Stress Accelerates Amyloid Pathology And Cognitive Decline In Appswe/Ps1De9 Mice, But Can Be Rescued By Briefly Blocking Glucocorticoid Receptors At Middle Age Alzheimers & Dementia. 13: 1479. DOI: 10.1016/J.Jalz.2017.07.555  1
2016 Hoeijmakers L, Ruigrok SR, Amelianchik A, Ivan D, Dam AV, Lucassen PJ, Korosi A. Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model. Brain, Behavior, and Immunity. PMID 28027926 DOI: 10.1016/J.Bbi.2016.12.023  1
2016 Reemst K, Noctor SC, Lucassen PJ, Hol EM. The Indispensable Roles of Microglia and Astrocytes during Brain Development. Frontiers in Human Neuroscience. 10: 566. PMID 27877121 DOI: 10.3389/Fnhum.2016.00566  1
2016 Naninck EF, Oosterink JE, Yam KY, de Vries LP, Schierbeek H, van Goudoever JB, Verkaik-Schakel RN, Plantinga JA, Plosch T, Lucassen PJ, Korosi A. Early micronutrient supplementation protects against early stress-induced cognitive impairments. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27770020 DOI: 10.1096/Fj.201600834R  1
2016 Hoeijmakers L, Heinen Y, van Dam AM, Lucassen PJ, Korosi A. Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics? Frontiers in Human Neuroscience. 10: 398. PMID 27555812 DOI: 10.3389/Fnhum.2016.00398  1
2016 Schouten M, Bielefeld P, Fratantoni SA, Hubens CJ, Piersma SR, Pham TV, Voskuyl RA, Lucassen PJ, Jimenez CR, Fitzsimons CP. Multi-omics profile of the mouse dentate gyrus after kainic acid-induced status epilepticus. Scientific Data. 3: 160068. PMID 27529540 DOI: 10.1038/Sdata.2016.68  1
2016 Kandola A, Hendrikse J, Lucassen PJ, Yücel M. Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment. Frontiers in Human Neuroscience. 10: 373. PMID 27524962 DOI: 10.3389/Fnhum.2016.00373  0.01
2016 Schrantee A, Tamminga HG, Bouziane C, Bottelier MA, Bron EE, Mutsaerts HM, Zwinderman AH, Groote IR, Rombouts SA, Lindauer RJ, Klein S, Niessen WJ, Opmeer BC, Boer F, Lucassen PJ, et al. Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial. Jama Psychiatry. PMID 27487479 DOI: 10.1001/Jamapsychiatry.2016.1572  1
2016 Zhao J, Verwer RW, van Wamelen DJ, Qi XR, Gao SF, Lucassen PJ, Swaab DF. Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide. Journal of Psychiatric Research. 82: 8-15. PMID 27450072 DOI: 10.1016/J.Jpsychires.2016.06.017  1
2016 Lesuis SL, Maurin H, Borghgraef P, Lucassen PJ, Van Leuven F, Krugers HJ. Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease. Oncotarget. PMID 27259247 DOI: 10.18632/Oncotarget.9776  1
2016 Fitzsimons CP, Herbert J, Schouten M, Meijer OC, Lucassen PJ, Lightman S. Circadian and Ultradian Glucocorticoid Rhythmicity: Implications for the Effects of Glucocorticoids on Neural Stem Cells and Adult Hippocampal Neurogenesis. Frontiers in Neuroendocrinology. PMID 27234350 DOI: 10.1016/J.Yfrne.2016.05.001  1
2016 Hu P, Wang Y, Liu J, Meng FT, Qi XR, Chen L, van Dam AM, Joëls M, Lucassen PJ, Zhou JN. Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior. Hippocampus. PMID 26860546 DOI: 10.1002/Hipo.22574  1
2015 Bolijn S, Lucassen PJ. How the Body Talks to the Brain; Peripheral Mediators of Physical Activity-Induced Proliferation in the Adult Hippocampus. Brain Plasticity (Amsterdam, Netherlands). 1: 5-27. PMID 29765833 DOI: 10.3233/BPL-150020  0.01
2015 Herbert J, Lucassen PJ. Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis - what do we need to know? Frontiers in Neuroendocrinology. PMID 26746105 DOI: 10.1016/J.Yfrne.2015.12.001  1
2015 Kanatsou S, Fearey BC, Kuil LE, Lucassen PJ, Harris AP, Seckl JR, Krugers H, Joels M. Correction: Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. Plos One. 10: e0145706. PMID 26684195 DOI: 10.1371/Journal.Pone.0145706  1
2015 Kanatsou S, Fearey BC, Kuil LE, Lucassen PJ, Harris AP, Seckl JR, Krugers H, Joels M. Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. Plos One. 10: e0142012. PMID 26600250 DOI: 10.1371/Journal.Pone.0142012  1
2015 Yam KY, Schipper L, Naninck EF, la Fleur SE, Oosting A, van der Beek EM, Lucassen PJ, Korosi A. Involvement of fat metabolism in the early-life stress induced cognitive impairments. Psychoneuroendocrinology. 61: 34. PMID 26383369 DOI: 10.1016/J.Psyneuen.2015.07.481  1
2015 Lucassen PJ, Oomen CA, Naninck EF, Fitzsimons CP, van Dam AM, Czeh B, Korosi A. Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation. Cold Spring Harbor Perspectives in Biology. 7. PMID 26330520 DOI: 10.1101/Cshperspect.A021303  1
2015 Loi M, Mossink JC, Meerhoff GF, Den Blaauwen JL, Lucassen PJ, Joëls M. Effects of early-life stress on cognitive function and hippocampal structure in female rodents. Neuroscience. PMID 26297897 DOI: 10.1016/J.Neuroscience.2015.08.024  1
2015 Klomp A, Václavů L, Meerhoff GF, Reneman L, Lucassen PJ. Correction: Effects of Chronic Fluoxetine Treatment on Neurogenesis and Tryptophan Hydroxylase Expression in Adolescent and Adult Rats. Plos One. 10: e0135876. PMID 26295703 DOI: 10.1371/journal.pone.0135876  1
2015 Yam KY, Naninck EF, Schmidt MV, Lucassen PJ, Korosi A. Early-life adversity programs emotional functions and the neuroendocrine stress system: the contribution of nutrition, metabolic hormones and epigenetic mechanisms. Stress (Amsterdam, Netherlands). 18: 328-42. PMID 26260665 DOI: 10.3109/10253890.2015.1064890  1
2015 Schouten M, Fratantoni SA, Hubens CJ, Piersma SR, Pham TV, Bielefeld P, Voskuyl RA, Lucassen PJ, Jimenez CR, Fitzsimons CP. MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. Scientific Reports. 5: 12448. PMID 26207921 DOI: 10.1038/Srep12448  1
2015 Oosterink JE, Naninck EF, Korosi A, Lucassen PJ, van Goudoever JB, Schierbeek H. Accurate measurement of the essential micronutrients methionine, homocysteine, vitamins B6, B12, B9 and their metabolites in plasma, brain and maternal milk of mice using LC/MS ion trap analysis. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 998: 106-13. PMID 26197436 DOI: 10.1016/J.Jchromb.2015.07.008  1
2015 van der Marel K, Bouet V, Meerhoff GF, Freret T, Boulouard M, Dauphin F, Klomp A, Lucassen PJ, Homberg JR, Dijkhuizen RM, Reneman L. Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis. Neuroscience. PMID 25934041 DOI: 10.1016/J.Neuroscience.2015.04.044  1
2015 Doorn KJ, Brevé JJ, Drukarch B, Boddeke HW, Huitinga I, Lucassen PJ, van Dam AM. Brain region-specific gene expression profiles in freshly isolated rat microglia. Frontiers in Cellular Neuroscience. 9: 84. PMID 25814934 DOI: 10.3389/Fncel.2015.00084  1
2015 Schrantee A, Václav? L, Heijtel DF, Caan MW, Gsell W, Lucassen PJ, Nederveen AJ, Booij J, Reneman L. Dopaminergic system dysfunction in recreational dexamphetamine users. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1172-80. PMID 25394786 DOI: 10.1038/Npp.2014.301  1
2015 Naninck EF, Hoeijmakers L, Kakava-Georgiadou N, Meesters A, Lazic SE, Lucassen PJ, Korosi A. Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice. Hippocampus. 25: 309-28. PMID 25269685 DOI: 10.1002/Hipo.22374  1
2014 Hoeijmakers L, Lucassen PJ, Korosi A. The interplay of early-life stress, nutrition, and immune activation programs adult hippocampal structure and function. Frontiers in Molecular Neuroscience. 7: 103. PMID 25620909 DOI: 10.3389/Fnmol.2014.00103  1
2014 Kuipers SD, Bramham CR, Cameron HA, Fitzsimons CP, Korosi A, Lucassen PJ. Environmental control of adult neurogenesis: from hippocampal homeostasis to behavior and disease. Neural Plasticity. 2014: 808643. PMID 25580306 DOI: 10.1155/2014/808643  1
2014 Marlatt MW, Bauer J, Aronica E, van Haastert ES, Hoozemans JJ, Joels M, Lucassen PJ. Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plasticity. 2014: 693851. PMID 25215243 DOI: 10.1155/2014/693851  1
2014 Doorn KJ, Drukarch B, van Dam AM, Lucassen PJ. Hippocampal proliferation is increased in presymptomatic Parkinson's disease and due to microglia. Neural Plasticity. 2014: 959154. PMID 25197578 DOI: 10.1155/2014/959154  1
2014 Doorn KJ, Moors T, Drukarch B, van de Berg WDj, Lucassen PJ, van Dam AM. Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta Neuropathologica Communications. 2: 90. PMID 25099483 DOI: 10.1186/S40478-014-0090-1  1
2014 Fitzsimons CP, van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, van den Hurk M, Boks MP, Biojone C, Joca S, Steinbusch HW, Lunnon K, Mastroeni DF, Mill J, Lucassen PJ, et al. Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Molecular Neurodegeneration. 9: 25. PMID 24964731 DOI: 10.1186/1750-1326-9-25  1
2014 Boekhoorn K, van Dis V, Goedknegt E, Sobel A, Lucassen PJ, Hoogenraad CC. The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Developmental Neurobiology. 74: 1226-42. PMID 24909416 DOI: 10.1002/Dneu.22200  1
2014 Klomp A, Václav? L, Meerhoff GF, Reneman L, Lucassen PJ. Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats. Plos One. 9: e97603. PMID 24827731 DOI: 10.1371/Journal.Pone.0097603  1
2014 Hoeijmakers L, Harbich D, Schmid B, Lucassen PJ, Wagner KV, Schmidt MV, Hartmann J. Depletion of FKBP51 in female mice shapes HPA axis activity. Plos One. 9: e95796. PMID 24759731 DOI: 10.1371/Journal.Pone.0095796  1
2014 Loi M, Koricka S, Lucassen PJ, Joëls M. Age- and sex-dependent effects of early life stress on hippocampal neurogenesis. Frontiers in Endocrinology. 5: 13. PMID 24600436 DOI: 10.3389/Fendo.2014.00013  1
2014 Bielefeld P, van Vliet EA, Gorter JA, Lucassen PJ, Fitzsimons CP. Different subsets of newborn granule cells: a possible role in epileptogenesis? The European Journal of Neuroscience. 39: 1-11. PMID 24387591 DOI: 10.1111/Ejn.12387  1
2014 Lucassen PJ, Pruessner J, Sousa N, Almeida OF, Van Dam AM, Rajkowska G, Swaab DF, Czéh B. Neuropathology of stress. Acta Neuropathologica. 127: 109-35. PMID 24318124 DOI: 10.1007/S00401-013-1223-5  1
2014 Doorn KJ, Goudriaan A, Blits-Huizinga C, Bol JG, Rozemuller AJ, Hoogland PV, Lucassen PJ, Drukarch B, van de Berg WD, van Dam AM. Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients. Brain Pathology (Zurich, Switzerland). 24: 152-65. PMID 24033473 DOI: 10.1111/Bpa.12088  1
2014 van der Marel K, Klomp A, Meerhoff GF, Schipper P, Lucassen PJ, Homberg JR, Dijkhuizen RM, Reneman L. Long-term oral methylphenidate treatment in adolescent and adult rats: differential effects on brain morphology and function. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 263-73. PMID 23851400 DOI: 10.1038/Npp.2013.169  1
2014 Wang Q, Verweij EW, Krugers HJ, Joels M, Swaab DF, Lucassen PJ. Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure & Function. 219: 1615-26. PMID 23748930 DOI: 10.1007/S00429-013-0589-4  1
2013 Hu P, Liu J, Zhao J, Qi XR, Qi CC, Lucassen PJ, Zhou JN. All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation. Translational Psychiatry. 3: e336. PMID 24346134 DOI: 10.1038/tp.2013.98  1
2013 Lucassen PJ, Naninck EF, van Goudoever JB, Fitzsimons C, Joels M, Korosi A. Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics. Trends in Neurosciences. 36: 621-31. PMID 23998452 DOI: 10.1016/J.Tins.2013.08.002  1
2013 Marlatt MW, Potter MC, Bayer TA, van Praag H, Lucassen PJ. Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer's disease. Current Topics in Behavioral Neurosciences. 15: 313-40. PMID 23670818 DOI: 10.1007/7854_2012_237  1
2013 Zalachoras I, Houtman R, Atucha E, Devos R, Tijssen AM, Hu P, Lockey PM, Datson NA, Belanoff JK, Lucassen PJ, Joëls M, de Kloet ER, Roozendaal B, Hunt H, Meijer OC. Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator. Proceedings of the National Academy of Sciences of the United States of America. 110: 7910-5. PMID 23613579 DOI: 10.1073/Pnas.1219411110  1
2013 Wang Q, Van Heerikhuize J, Aronica E, Kawata M, Seress L, Joels M, Swaab DF, Lucassen PJ. Glucocorticoid receptor protein expression in human hippocampus; stability with age. Neurobiology of Aging. 34: 1662-73. PMID 23290588 DOI: 10.1016/J.Neurobiolaging.2012.11.019  1
2013 Qi XR, Kamphuis W, Wang S, Wang Q, Lucassen PJ, Zhou JN, Swaab DF. Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients. Psychoneuroendocrinology. 38: 863-70. PMID 23137715 DOI: 10.1016/J.Psyneuen.2012.09.014  1
2013 Fitzsimons CP, van Hooijdonk LW, Schouten M, Zalachoras I, Brinks V, Zheng T, Schouten TG, Saaltink DJ, Dijkmans T, Steindler DA, Verhaagen J, Verbeek FJ, Lucassen PJ, de Kloet ER, Meijer OC, et al. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Molecular Psychiatry. 18: 993-1005. PMID 22925833 DOI: 10.1038/Mp.2012.123  1
2013 Lucassen PJ, Fitzsimons CP, Korosi A, Joels M, Belzung C, Abrous DN. Stressing new neurons into depression? Molecular Psychiatry. 18: 396-7. PMID 22547116 DOI: 10.1038/Mp.2012.39  1
2012 Lucassen PJ. Chemotherapy modulates specific aspects of cognition parallel to neurogenesis (commentary on Nokia et al.). The European Journal of Neuroscience. 36: 3519-20. PMID 23205775 DOI: 10.1111/Ejn.12056  1
2012 Hu P, Oomen C, van Dam AM, Wester J, Zhou JN, Joëls M, Lucassen PJ. A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation. Plos One. 7: e46224. PMID 23049985 DOI: 10.1371/Journal.Pone.0046224  1
2012 Claessens SE, Belanoff JK, Kanatsou S, Lucassen PJ, Champagne DL, de Kloet ER. Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: towards a rescue strategy. Brain Research. 1482: 1-12. PMID 22985498 DOI: 10.1016/J.Brainres.2012.08.017  1
2012 Doorn KJ, Lucassen PJ, Boddeke HW, Prins M, Berendse HW, Drukarch B, van Dam AM. Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease. Progress in Neurobiology. 98: 222-38. PMID 22732265 DOI: 10.1016/J.Pneurobio.2012.06.005  1
2012 Saaltink DJ, HÃ¥vik B, Verissimo CS, Lucassen PJ, Vreugdenhil E. Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis. The Journal of Comparative Neurology. 520: 2805-23. PMID 22605579 DOI: 10.1002/Cne.23144  1
2012 Schouten M, Buijink MR, Lucassen PJ, Fitzsimons CP. New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs. Frontiers in Neuroscience. 6: 25. PMID 22363255 DOI: 10.3389/Fnins.2012.00025  1
2012 Marlatt MW, Potter MC, Lucassen PJ, van Praag H. Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice. Developmental Neurobiology. 72: 943-52. PMID 22252978 DOI: 10.1002/Dneu.22009  1
2012 Krugers HJ, Oomen CA, Gumbs M, Li M, Velzing EH, Joels M, Lucassen PJ. Maternal deprivation and dendritic complexity in the basolateral amygdala. Neuropharmacology. 62: 534-7. PMID 21964522 DOI: 10.1016/J.Neuropharm.2011.09.022  1
2012 Wang Q, Joels M, Swaab DF, Lucassen PJ. Hippocampal GR expression is increased in elderly depressed females. Neuropharmacology. 62: 527-33. PMID 21945289 DOI: 10.1016/J.Neuropharm.2011.09.014  1
2012 Korosi A, Naninck EF, Oomen CA, Schouten M, Krugers H, Fitzsimons C, Lucassen PJ. Early-life stress mediated modulation of adult neurogenesis and behavior. Behavioural Brain Research. 227: 400-9. PMID 21821065 DOI: 10.1016/J.Bbr.2011.07.037  1
2012 Datson NA, Speksnijder N, Mayer JL, Steenbergen PJ, Korobko O, Goeman J, de Kloet ER, Joëls M, Lucassen PJ. The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus. Hippocampus. 22: 359-71. PMID 21184481 DOI: 10.1002/Hipo.20905  1
2012 Fitzsimons CP, Vreugdenhil E, Lucassen PJ. Inhibition of adult neurogenesis through ERK5 knockdown impairs complex hippocampus-dependent spatial memory tasks Future Neurology. 7: 531-535. DOI: 10.2217/Fnl.12.55  1
2011 Xiao AW, He J, Wang Q, Luo Y, Sun Y, Zhou YP, Guan Y, Lucassen PJ, Dai JP. The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease. Neuroscience Bulletin. 27: 287-99. PMID 21934724 DOI: 10.1007/S12264-011-1736-7  1
2011 Novati A, Hulshof HJ, Koolhaas JM, Lucassen PJ, Meerlo P. Chronic sleep restriction causes a decrease in hippocampal volume in adolescent rats, which is not explained by changes in glucocorticoid levels or neurogenesis. Neuroscience. 190: 145-55. PMID 21718758 DOI: 10.1016/J.Neuroscience.2011.06.027  1
2011 Marlatt MW, Philippens I, Manders E, Czéh B, Joels M, Krugers H, Lucassen PJ. Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Experimental Neurology. 230: 291-301. PMID 21605555 DOI: 10.1016/J.Expneurol.2011.05.008  1
2011 Van Bokhoven P, Oomen CA, Hoogendijk WJ, Smit AB, Lucassen PJ, Spijker S. Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment. The European Journal of Neuroscience. 33: 1833-40. PMID 21488984 DOI: 10.1111/J.1460-9568.2011.07668.X  1
2011 Naninck EF, Lucassen PJ, Bakker J. Sex differences in adolescent depression: do sex hormones determine vulnerability? Journal of Neuroendocrinology. 23: 383-92. PMID 21418338 DOI: 10.1111/J.1365-2826.2011.02125.X  1
2011 Lemmens MA, Sierksma AS, Rutten BP, Dennissen F, Steinbusch HW, Lucassen PJ, Schmitz C. Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease. Brain Structure & Function. 216: 227-37. PMID 21409417 DOI: 10.1007/S00429-011-0305-1  1
2011 Eendebak RJ, Lucassen PJ, Fitzsimons CP. Nuclear receptors and microRNAs: Who regulates the regulators in neural stem cells? Febs Letters. 585: 717-22. PMID 21295033 DOI: 10.1016/J.Febslet.2011.01.039  1
2011 Bruel-Jungerman E, Lucassen PJ, Francis F. Cholinergic influences on cortical development and adult neurogenesis. Behavioural Brain Research. 221: 379-88. PMID 21272598 DOI: 10.1016/J.Bbr.2011.01.021  1
2011 van Tijn P, Kamphuis W, Marlatt MW, Hol EM, Lucassen PJ. Presenilin mouse and zebrafish models for dementia: focus on neurogenesis. Progress in Neurobiology. 93: 149-64. PMID 21056616 DOI: 10.1016/J.Pneurobio.2010.10.008  1
2011 Oomen CA, Soeters H, Audureau N, Vermunt L, van Hasselt FN, Manders EM, Joëls M, Krugers H, Lucassen PJ. Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats. Psychopharmacology. 214: 249-60. PMID 20589492 DOI: 10.1007/S00213-010-1922-8  1
2011 Lucassen PJ, Fitzsimons CP, Vreugdenhil E, Hu P, Oomen C, Revsin Y, Joëls M, de Kloet ER. Regulation of Structural Plasticity and Neurogenesis during Stress and Diabetes; Protective Effects of Glucocorticoid Receptor Antagonists Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis. 103-120. DOI: 10.1002/9783527633968.ch6  1
2010 Krugers HJ, Lucassen PJ, Karst H, Joëls M. Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment. Frontiers in Synaptic Neuroscience. 2: 24. PMID 21423510 DOI: 10.3389/Fnsyn.2010.00024  1
2010 Oomen CA, Soeters H, Audureau N, Vermunt L, van Hasselt FN, Manders EM, Joëls M, Lucassen PJ, Krugers H. Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6635-45. PMID 20463226 DOI: 10.1523/Jneurosci.0247-10.2010  1
2010 Marlatt MW, Lucassen PJ, van Praag H. Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. Brain Research. 1341: 93-9. PMID 20381469 DOI: 10.1016/J.Brainres.2010.03.086  1
2010 Christensen DZ, Schneider-Axmann T, Lucassen PJ, Bayer TA, Wirths O. Accumulation of intraneuronal Abeta correlates with ApoE4 genotype. Acta Neuropathologica. 119: 555-66. PMID 20217101 DOI: 10.1007/S00401-010-0666-1  1
2010 Lucassen PJ, Stumpel MW, Wang Q, Aronica E. Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology. 58: 940-9. PMID 20138063 DOI: 10.1016/J.Neuropharm.2010.01.012  1
2010 Marlatt MW, Lucassen PJ. Neurogenesis and Alzheimer's disease: Biology and pathophysiology in mice and men. Current Alzheimer Research. 7: 113-25. PMID 19860727 DOI: 10.2174/156720510790691362  1
2010 Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen PJ, Multhaup G, Brody DL, Esparza T, Ingelsson M, Kalimo H, Lannfelt L, Bayer TA. Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 85-96. PMID 19823761 DOI: 10.1007/S00702-009-0314-X  1
2010 Lucassen PJ, Meerlo P, Naylor AS, van Dam AM, Dayer AG, Fuchs E, Oomen CA, Czéh B. Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 20: 1-17. PMID 19748235 DOI: 10.1016/J.Euroneuro.2009.08.003  1
2009 Boer K, Lucassen PJ, Spliet WG, Vreugdenhil E, van Rijen PC, Troost D, Jansen FE, Aronica E. Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers. Epilepsia. 50: 2629-37. PMID 19583781 DOI: 10.1111/J.1528-1167.2009.02191.X  1
2009 Lucassen PJ, Scheper W, Van Someren EJ. Adult neurogenesis and the unfolded protein response; new cellular and molecular avenues in sleep research. Sleep Medicine Reviews. 13: 183-6. PMID 19345123 DOI: 10.1016/J.Smrv.2008.12.004  1
2009 Joëls M, Krugers HJ, Lucassen PJ, Karst H. Corticosteroid effects on cellular physiology of limbic cells. Brain Research. 1293: 91-100. PMID 19332034 DOI: 10.1016/J.Brainres.2009.03.036  1
2009 Oomen CA, Girardi CE, Cahyadi R, Verbeek EC, Krugers H, Joëls M, Lucassen PJ. Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. Plos One. 4: e3675. PMID 19180242 DOI: 10.1371/Journal.Pone.0003675  1
2009 Joosen MJ, Jousma E, van den Boom TM, Kuijpers WC, Smit AB, Lucassen PJ, van Helden HP. Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology. 30: 72-80. PMID 19100287 DOI: 10.1016/J.Neuro.2008.11.010  1
2009 Lucassen PJ, Bosch OJ, Jousma E, Krömer SA, Andrew R, Seckl JR, Neumann ID. Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2. The European Journal of Neuroscience. 29: 97-103. PMID 19032587 DOI: 10.1111/J.1460-9568.2008.06543.X  1
2009 Marlatt MW, Hoozemans JJ, Veerhuis R, Lucassen PJ. Alzheimer’s disease and adult neurogenesis—Are endogenous stem cells part of the solution? Us Neurology. 5: 12-14. DOI: 10.17925/Usn.2009.05.01.12  1
2009 Lucassen PJ, Marlatt M, Bauer J, Wouda J, Hoozemans JJM. Coordinated evaluation of astrogliosis, microglial activation and proliferation in the Alzheimer hippocampus in relation to cognitive status and amyloid pathology Alzheimers & Dementia. 5: 312. DOI: 10.1016/J.Jalz.2009.04.487  1
2008 Marlatt MW, Lucassen PJ, Perry G, Smith MA, Zhu X. Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. Journal of Alzheimer's Disease : Jad. 15: 199-210. PMID 18953109 DOI: 10.3233/Jad-2008-15206  1
2008 Boekhoorn K, Sarabdjitsingh A, Kommerie H, de Punder K, Schouten T, Lucassen PJ, Vreugdenhil E. Doublecortin (DCX) and doublecortin-like (DCL) are differentially expressed in the early but not late stages of murine neocortical development. The Journal of Comparative Neurology. 507: 1639-52. PMID 18231966 DOI: 10.1002/Cne.21646  1
2008 Thompson A, Boekhoorn K, Van Dam AM, Lucassen PJ. Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence? Genes, Brain, and Behavior. 7: 28-42. PMID 18184368 DOI: 10.1111/J.1601-183X.2007.00379.X  1
2008 Simic G, Mladinov M, Seso Simic D, Jovanov Milosevic N, Islam A, Pajtak A, Barisic N, Sertic J, Lucassen PJ, Hof PR, Kruslin B. Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy. Acta Neuropathologica. 115: 313-26. PMID 18075747 DOI: 10.1007/S00401-007-0327-1  1
2008 Lucassen PJ, Oomen CA, Dam Av, Czéh B. 18 Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammation Cold Spring Harbor Monograph Archive. 52: 363-395. DOI: 10.1101/087969784.52.363  1
2007 Verwer RW, Sluiter AA, Balesar RA, Baayen JC, Noske DP, Dirven CM, Wouda J, van Dam AM, Lucassen PJ, Swaab DF. Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin. Brain : a Journal of Neurology. 130: 3321-35. PMID 18055496 DOI: 10.1093/Brain/Awm264  1
2007 Oomen CA, Mayer JL, de Kloet ER, Joëls M, Lucassen PJ. Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress. The European Journal of Neuroscience. 26: 3395-401. PMID 18052970 DOI: 10.1111/J.1460-9568.2007.05972.X  1
2007 Kuhn HG, Cooper-Kuhn CM, Boekhoorn K, Lucassen PJ. Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant? European Archives of Psychiatry and Clinical Neuroscience. 257: 281-9. PMID 17639447 DOI: 10.1007/S00406-007-0732-4  1
2007 Veenema AH, de Kloet ER, de Wilde MC, Roelofs AJ, Kawata M, Buwalda B, Neumann ID, Koolhaas JM, Lucassen PJ. Differential effects of stress on adult hippocampal cell proliferation in low and high aggressive mice. Journal of Neuroendocrinology. 19: 489-98. PMID 17561881 DOI: 10.1111/J.1365-2826.2007.01555.X  1
2007 Joëls M, Karst H, Krugers HJ, Lucassen PJ. Chronic stress: implications for neuronal morphology, function and neurogenesis. Frontiers in Neuroendocrinology. 28: 72-96. PMID 17544065 DOI: 10.1016/J.Yfrne.2007.04.001  1
2007 Czéh B, Lucassen PJ. What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated? European Archives of Psychiatry and Clinical Neuroscience. 257: 250-60. PMID 17401728 DOI: 10.1007/S00406-007-0728-0  1
2007 Sennvik K, Boekhoorn K, Lasrado R, Terwel D, Verhaeghe S, Korr H, Schmitz C, Tomiyama T, Mori H, Krugers H, Joels M, Ramakers GJ, Lucassen PJ, Van Leuven F. Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2149-61. PMID 17341679 DOI: 10.1096/Fj.06-7735Com  1
2007 Vreugdenhil E, Kolk SM, Boekhoorn K, Fitzsimons CP, Schaaf M, Schouten T, Sarabdjitsingh A, Sibug R, Lucassen PJ. Doublecortin-like, a microtubule-associated protein expressed in radial glia, is crucial for neuronal precursor division and radial process stability. The European Journal of Neuroscience. 25: 635-48. PMID 17313568 DOI: 10.1111/J.1460-9568.2007.05318.X  1
2007 Krugers HJ, van der Linden S, van Olst E, Alfarez DN, Maslam S, Lucassen PJ, Joëls M. Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats. Synapse (New York, N.Y.). 61: 221-30. PMID 17230550 DOI: 10.1002/Syn.20359  1
2006 Lucassen PJ, Heine VM, Muller MB, van der Beek EM, Wiegant VM, De Kloet ER, Joels M, Fuchs E, Swaab DF, Czeh B. Stress, depression and hippocampal apoptosis. Cns & Neurological Disorders Drug Targets. 5: 531-46. PMID 17073656 DOI: 10.2174/187152706778559273  1
2006 Mayer JL, Klumpers L, Maslam S, de Kloet ER, Joëls M, Lucassen PJ. Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis. Journal of Neuroendocrinology. 18: 629-31. PMID 16867184 DOI: 10.1111/J.1365-2826.2006.01455.X  1
2006 Boekhoorn K, Joels M, Lucassen PJ. Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiology of Disease. 24: 1-14. PMID 16814555 DOI: 10.1016/J.Nbd.2006.04.017  1
2006 Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O, Ramakers GJ, de Vos K, Krugers H, Tomiyama T, Mori H, Joels M, van Leuven F, Lucassen PJ. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3514-23. PMID 16571759 DOI: 10.1523/Jneurosci.5425-05.2006  1
2006 Rodríguez-Contreras A, de Lange RP, Lucassen PJ, Borst JG. Branching of calyceal afferents during postnatal development in the rat auditory brainstem. The Journal of Comparative Neurology. 496: 214-28. PMID 16538676 DOI: 10.1002/Cne.20918  1
2006 Sennvik K, Boekhoorn K, Lasrado R, Terwel D, Verhaeghe S, Joëls M, Lucassen P, Leuven FV. P1-015: Tau-4R suppresses precursor proliferation and promotes neuronal differentiation in the hippocampus of humanized tau knock-in/knock-out mice Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.390  1
2005 Swaab DF, Bao AM, Lucassen PJ. The stress system in the human brain in depression and neurodegeneration. Ageing Research Reviews. 4: 141-94. PMID 15996533 DOI: 10.1016/J.Arr.2005.03.003  1
2005 Heine VM, Zareno J, Maslam S, Joëls M, Lucassen PJ. Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression. The European Journal of Neuroscience. 21: 1304-14. PMID 15813940 DOI: 10.1111/J.1460-9568.2005.03951.X  1
2005 Lucassen PJ. Handbook of Clinical Neurology, Third Series. Part I: Nuclei of the Human Hypothalamus Journal of Neuropathology and Experimental Neurology. 64: 260-261. DOI: 10.1093/Jnen/64.3.260-B  0.01
2004 Joëls M, Karst H, Alfarez D, Heine VM, Qin Y, van Riel E, Verkuyl M, Lucassen PJ, Krugers HJ. Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus. Stress (Amsterdam, Netherlands). 7: 221-31. PMID 16019587 DOI: 10.1080/10253890500070005  1
2004 Nair SM, Karst H, Dumas T, Phillips R, Sapolsky RM, Rumpff-van Essen L, Maslam S, Lucassen PJ, Joëls M. Gene expression profiles associated with survival of individual rat dentate cells after endogenous corticosteroid deprivation. The European Journal of Neuroscience. 20: 3233-43. PMID 15610156 DOI: 10.1111/J.1460-9568.2004.03819.X  1
2004 Fuchs E, Czéh B, Kole MH, Michaelis T, Lucassen PJ. Alterations of neuroplasticity in depression: the hippocampus and beyond. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 14: S481-90. PMID 15550346 DOI: 10.1016/J.Euroneuro.2004.09.002  1
2004 Heine VM, Maslam S, Joëls M, Lucassen PJ. Increased P27KIP1 protein expression in the dentate gyrus of chronically stressed rats indicates G1 arrest involvement. Neuroscience. 129: 593-601. PMID 15541881 DOI: 10.1016/J.Neuroscience.2004.07.048  1
2004 van der Beek EM, Wiegant VM, Schouten WG, van Eerdenburg FJ, Loijens LW, van der Plas C, Benning MA, de Vries H, de Kloet ER, Lucassen PJ. Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levels. Hippocampus. 14: 688-700. PMID 15318328 DOI: 10.1002/Hipo.10213  1
2004 Heine VM, Maslam S, Joëls M, Lucassen PJ. Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation. Neurobiology of Aging. 25: 361-75. PMID 15123342 DOI: 10.1016/S0197-4580(03)00090-3  1
2004 Lucassen PJ, Fuchs E, Czéh B. Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex. Biological Psychiatry. 55: 789-96. PMID 15050859 DOI: 10.1016/J.Biopsych.2003.12.014  1
2004 Heine VM, Maslam S, Zareno J, Joëls M, Lucassen PJ. Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible. The European Journal of Neuroscience. 19: 131-44. PMID 14750971 DOI: 10.1046/J.1460-9568.2003.03100.X  1
2003 Qin Y, Heine VM, Karst H, Lucassen PJ, Joëls M. Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissue. Journal of Neuroscience Methods. 131: 205-11. PMID 14659840 DOI: 10.1016/J.Jneumeth.2003.08.010  1
2003 DeRijk RH, Schaaf M, Stam FJ, de Jong IE, Swaab DF, Ravid R, Vreugdenhil E, Cidlowski JA, de Kloet ER, Lucassen PJ. Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry. Brain Research. Molecular Brain Research. 116: 17-26. PMID 12941457 DOI: 10.1016/S0169-328X(03)00209-2  1
2003 Gorter JA, Gonçalves Pereira PM, van Vliet EA, Aronica E, Lopes da Silva FH, Lucassen PJ. Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. Epilepsia. 44: 647-58. PMID 12752463 DOI: 10.1046/J.1528-1157.2003.53902.X  1
2002 Grootendorst J, Kempes MM, Lucassen PJ, Dalm S, de Kloet ER, Oitzl MS. Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J mice. Brain Research. 953: 281-5. PMID 12384263 DOI: 10.1016/S0006-8993(02)03399-1  1
2001 Müller MB, Lucassen PJ, Yassouridis A, Hoogendijk WJ, Holsboer F, Swaab DF. Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus. The European Journal of Neuroscience. 14: 1603-12. PMID 11860455 DOI: 10.1046/J.0953-816X.2001.01784.X  1
2001 Lucassen PJ, Vollmann-Honsdorf GK, Gleisberg M, Czéh B, De Kloet ER, Fuchs E. Chronic psychosocial stress differentially affects apoptosis in hippocampal subregions and cortex of the adult tree shrew. The European Journal of Neuroscience. 14: 161-6. PMID 11488960 DOI: 10.1046/J.0953-816X.2001.01629.X  1
2001 Fuchs E, Flügge G, Ohl F, Lucassen P, Vollmann-Honsdorf GK, Michaelis T. Psychosocial stress, glucocorticoids, and structural alterations in the tree shrew hippocampus. Physiology & Behavior. 73: 285-91. PMID 11438353 DOI: 10.1016/S0031-9384(01)00497-8  1
2001 Karssen AM, Meijer OC, van der Sandt IC, Lucassen PJ, de Lange EC, de Boer AG, de Kloet ER. Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain. Endocrinology. 142: 2686-94. PMID 11356720 DOI: 10.1210/Endo.142.6.8213  1
2001 Lucassen PJ, Müller MB, Holsboer F, Bauer J, Holtrop A, Wouda J, Hoogendijk WJ, De Kloet ER, Swaab DF. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. The American Journal of Pathology. 158: 453-68. PMID 11159183 DOI: 10.1016/S0002-9440(10)63988-0  1
2000 Lucassen PJ. Presenilins and Cellular Damage; A Link through Amyloid? Journal of Alzheimer's Disease : Jad. 2: 61-67. PMID 12536168 DOI: 10.3233/Jad-2000-2108  1
2000 Simic G, Lucassen PJ, Krsnik Z, Kruslin B, Kostovic I, Winblad B, Bogdanovi. nNOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease. Experimental Neurology. 165: 12-26. PMID 10964481 DOI: 10.1006/Exnr.2000.7448  1
2000 Simic G, Seso-Simic D, Lucassen PJ, Islam A, Krsnik Z, Cviko A, Jelasic D, Barisic N, Winblad B, Kostovic I, Kruslin B. Ultrastructural analysis and TUNEL demonstrate motor neuron apoptosis in Werdnig-Hoffmann disease. Journal of Neuropathology and Experimental Neurology. 59: 398-407. PMID 10888370 DOI: 10.1093/Jnen/59.5.398  1
1999 Eriksson C, Van Dam AM, Lucassen PJ, Bol JG, Winblad B, Schultzberg M. Immunohistochemical localization of interleukin-1beta, interleukin-1 receptor antagonist and interleukin-1beta converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid. Neuroscience. 93: 915-30. PMID 10473257 DOI: 10.1016/S0306-4522(99)00178-5  1
1999 Engels BM, Lucassen PJ, de Kloet ER, Vreugdenhil E. Regional distribution of a novel calcium/calmodulin-dependent protein kinase mRNA in the rat brain. Brain Research. 835: 365-8. PMID 10415397 DOI: 10.1016/S0006-8993(99)01636-4  1
1999 Vincent VA, De Groot CJ, Lucassen PJ, Portegies P, Troost D, Tilders FJ, Van Dam AM. Nitric oxide synthase expression and apoptotic cell death in brains of AIDS and AIDS dementia patients. Aids (London, England). 13: 317-26. PMID 10199221 DOI: 10.1097/00002030-199902250-00003  1
1998 Swaab DF, Lucassen PJ, Salehi A, Scherder EJ, van Someren EJ, Verwer RW. Reduced neuronal activity and reactivation in Alzheimer's disease. Progress in Brain Research. 117: 343-77. PMID 9932420 DOI: 10.1016/S0079-6123(08)64027-3  1
1998 Perry G, Nunomura A, Lucassen P, Lassmann H, Smith MA. Apoptosis and Alzheimer's disease. Science (New York, N.Y.). 282: 1268-9. PMID 9867630 DOI: 10.1126/Science.282.5392.1265H  1
1998 Lucassen PJ, van Someren EJ, Swaab DF. [Are active neurons a better defense against aging in Alzheimer's disease?]. Tijdschrift Voor Gerontologie En Geriatrie. 29: 177-84. PMID 9746932  1
1997 Lucassen PJ, Tilders FJ, Salehi A, Swaab DF. Neuropeptides vasopressin (AVP), oxytocin (OXT) and corticotropin-releasing hormone (CRH) in the human hypothalamus: activity changes in aging, Alzheimer's disease and depression. Aging (Milan, Italy). 9: 48-50. PMID 9358882 DOI: 10.1007/Bf03339703  1
1997 Lucassen PJ, Chung WC, Kamphorst W, Swaab DF. DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology. Journal of Neuropathology and Experimental Neurology. 56: 887-900. PMID 9258259 DOI: 10.1097/00005072-199708000-00007  1
1997 Williams A, Lucassen PJ, Ritchie D, Bruce M. PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie. Experimental Neurology. 144: 433-8. PMID 9168844 DOI: 10.1006/Exnr.1997.6424  1
1997 Lucassen PJ, Van Heerikhuize JJ, Guldenaar SE, Pool CW, Hofman MA, Swaab DF. Unchanged amounts of vasopressin mRNA in the supraoptic and paraventricular nucleus during aging and in Alzheimer's disease. Journal of Neuroendocrinology. 9: 297-305. PMID 9147293 DOI: 10.1046/J.1365-2826.1997.T01-1-00583.X  1
1997 Oitzl MS, Mulder M, Lucassen PJ, Havekes LM, Grootendorst J, de Kloet ER. Severe learning deficits in apolipoprotein E-knockout mice in a water maze task. Brain Research. 752: 189-96. PMID 9106456 DOI: 10.1016/S0006-8993(96)01448-5  1
1996 Te Koppele JM, Lucassen PJ, Sakkee AN, Van Asten JG, Ravid R, Swaab DF, Van Bezooijen CF. 8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer's disease. Neurobiology of Aging. 17: 819-26. PMID 9363791 DOI: 10.1016/S0197-4580(96)00165-0  1
1996 Hoogendijk WJ, van Someren EJ, Mirmiran M, Hofman MA, Lucassen PJ, Zhou JN, Swaab DF. Circadian rhythm-related behavioral disturbances and structural hypothalamic changes in Alzheimer's disease. International Psychogeriatrics / Ipa. 8: 245-52; discussion 2. PMID 9154571 DOI: 10.1017/S1041610297003426  1
1996 Lucassen PJ, Goudsmit E, Pool CW, Mengod G, Palacios JM, Raadsheer FC, Guldenaar SE, Swaab DF. In situ hybridization for vasopressin mRNA in the human supraoptic and paraventricular nucleus; quantitative aspects of formalin-fixed paraffin-embedded tissue sections as compared to cryostat sections. Journal of Neuroscience Methods. 64: 133. PMID 8869492  1
1995 Lucassen PJ, Hofman MA, Swaab DF. Increased light intensity prevents the age related loss of vasopressin-expressing neurons in the rat suprachiasmatic nucleus. Brain Research. 693: 261-6. PMID 8653418 DOI: 10.1016/0006-8993(95)00933-H  1
1995 Lucassen PJ, Williams A, Chung WC, Fraser H. Detection of apoptosis in murine scrapie. Neuroscience Letters. 198: 185-8. PMID 8552317 DOI: 10.1016/0304-3940(95)11995-9  1
1995 Raadsheer FC, van Heerikhuize JJ, Lucassen PJ, Hoogendijk WJ, Tilders FJ, Swaab DF. Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. The American Journal of Psychiatry. 152: 1372-6. PMID 7653697 DOI: 10.1176/Ajp.152.9.1372  1
1995 Lucassen PJ, Goudsmit E, Pool CW, Mengod G, Palacios JM, Raadsheer FC, Guldenaar SE, Swaab DF. In situ hybridization for vasopressin mRNA in the human supraoptic and paraventricular nucleus; quantitative aspects of formalin-fixed paraffin-embedded tissue sections as compared to cryostat sections. Journal of Neuroscience Methods. 57: 221-30. PMID 7609586 DOI: 10.1016/0165-0270(94)00152-7  1
1995 Lucassen PJ, Chung WC, Vermeulen JP, Van Lookeren Campagne M, Van Dierendonck JH, Swaab DF. Microwave-enhanced in situ end-labeling of fragmented DNA: parametric studies in relation to postmortem delay and fixation of rat and human brain. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 43: 1163-71. PMID 7560899 DOI: 10.1177/43.11.7560899  1
1995 van Lookeren Campagne M, Lucassen PJ, Vermeulen JP, Balázs R. NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain. The European Journal of Neuroscience. 7: 1627-40. PMID 7551189 DOI: 10.1111/J.1460-9568.1995.Tb01158.X  1
1994 Salehi A, Lucassen PJ, Pool CW, Gonatas NK, Ravid R, Swaab DF. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience. 59: 871-80. PMID 8058125 DOI: 10.1016/0306-4522(94)90291-7  1
1994 Swaab DF, Hofman MA, Lucassen PJ, Salehi A, Uylings HB. Neuronal atrophy, not cell death, is the main hallmark of Alzheimer's disease. Neurobiology of Aging. 15: 369-71; discussion 3. PMID 7936066 DOI: 10.1016/0197-4580(94)90037-X  1
1994 Lucassen PJ, Salehi A, Pool CW, Gonatas NK, Swaab DF. Activation of vasopressin neurons in aging and Alzheimer's disease. Journal of Neuroendocrinology. 6: 673-9. PMID 7894470 DOI: 10.1111/J.1365-2826.1994.Tb00634.X  1
1993 Swaab DF, Hofman MA, Lucassen PJ, Purba JS, Raadsheer FC, Van de Nes JA. Functional neuroanatomy and neuropathology of the human hypothalamus. Anatomy and Embryology. 187: 317-30. PMID 8512084 DOI: 10.1007/Bf00185889  1
1993 Lucassen PJ, Ravid R, Gonatas NK, Swaab DF. Activation of the human supraoptic and paraventricular nucleus neurons with aging and in Alzheimer's disease as judged from increasing size of the Golgi apparatus. Brain Research. 632: 105-13. PMID 8149218 DOI: 10.1016/0006-8993(93)91144-H  1
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