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Ashley I. Bush, Ph.D., D.P.M., M.B.,B.S. - Publications

Affiliations: 
Psychiatry Mental Health Research Institute, University of Melbourne, Parkville, Victoria, Australia 
Area:
Alzheimer's Disease, metals, zinc, copper, schizophrenia, bipolar disorder, ALS, neurodegeneration
Website:
http://connects.catalyst.harvard.edu/profiles/profile/person/32567

354 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Tamano H, Oneta N, Shioya A, Adlard PA, Bush AI, Takeda A. In vivo synaptic activity-independent co-uptakes of amyloid β and Zn into dentate granule cells in the normal brain. Scientific Reports. 9: 6498. PMID 31019269 DOI: 10.1038/s41598-019-43012-0  0.72
2019 Meiklejohn H, Mostaid MS, Luza S, Mancuso SG, Kang D, Atherton S, Rothmond DA, Weickert CS, Opazo CM, Pantelis C, Bush AI, Everall IP, Bousman CA. Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia. Journal of Psychiatric Research. 113: 51-57. PMID 30901725 DOI: 10.1016/j.jpsychires.2019.03.005  0.36
2019 Bousman CA, Luza S, Mancuso SG, Kang D, Opazo CM, Mostaid MS, Cropley V, McGorry P, Shannon Weickert C, Pantelis C, Bush AI, Everall IP. Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia. Scientific Reports. 9: 2307. PMID 30783160 DOI: 10.1038/s41598-019-38490-1  0.36
2019 Ashton NJ, Nevado-Holgado AJ, Barber IS, Lynham S, Gupta V, Chatterjee P, Goozee K, Hone E, Pedrini S, Blennow K, Schöll M, Zetterberg H, Ellis KA, Bush AI, Rowe CC, et al. A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's disease. Science Advances. 5: eaau7220. PMID 30775436 DOI: 10.1126/sciadv.aau7220  1
2019 McInerney MP, Pan Y, Volitakis I, Bush AI, Short JL, Nicolazzo JA. The effects of clioquinol on P-glycoprotein expression and biometal distribution in the mouse brain microvasculature. Journal of Pharmaceutical Sciences. PMID 30738852 DOI: 10.1016/j.xphs.2019.01.030  0.64
2019 Billings JL, Gordon SL, Rawling T, Doble PA, Bush AI, Adlard PA, Finkelstein DI, Hare DJ. L-DOPA modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease. Journal of Neurochemistry. PMID 30716176 DOI: 10.1111/jnc.14676  0.72
2019 Bray L, Volitakis I, Ayton S, Bush AI, Adlard PA. Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica? Nutrients. 11. PMID 30669644 DOI: 10.3390/nu11010206  0.72
2019 Tamano H, Suzuki H, Kobuchi S, Adlard PA, Bush AI, Takeda A. Difference in ability for extracellular Zn influx between human and rat amyloid β and its significance. Neurotoxicology. PMID 30664975 DOI: 10.1016/j.neuro.2019.01.005  0.72
2019 Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez MIG, Johannsen VA, Cook MJ, Crowston JG, Hill AF, Duce JA, Bush AI, Trounce IA. Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity. Molecular Neurobiology. PMID 30612335 DOI: 10.1007/s12035-018-1460-7  0.44
2018 Tamano H, Suzuki H, Murakami T, Fujii H, Adlard PA, Bush AI, Takeda A. Amyloid β-Induced Rapid Zn Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia. Molecular Neurobiology. PMID 30460616 DOI: 10.1007/s12035-018-1429-6  0.72
2018 Cardoso BR, Roberts BR, Malpas CB, Vivash L, Genc S, Saling MM, Desmond P, Steward C, Hicks RJ, Callahan J, Brodtmann A, Collins S, Macfarlane S, Corcoran NM, Hovens CM, ... ... Bush AI, et al. Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 30215171 DOI: 10.1007/s13311-018-0662-z  0.6
2018 Sedjahtera A, Gunawan L, Bray L, Hung LW, Parsons J, Okamura N, Villemagne VL, Yanai K, Liu XM, Chan J, Bush AI, Finkelstein DI, Barnham KJ, Cherny RA, Adlard PA. Targeting metals rescues the phenotype in an animal model of tauopathy. Metallomics : Integrated Biometal Science. PMID 30168573 DOI: 10.1039/c8mt00153g  0.8
2018 Venkataramani V, Doeppner TR, Willkommen D, Cahill CM, Xin Y, Ye G, Liu Y, Southon A, Aron A, Au-Yeung HY, Huang X, Lahiri DK, Wang F, Bush AI, Wulf GG, et al. Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin. Journal of Neurochemistry. PMID 30152072 DOI: 10.1111/jnc.14580  0.76
2018 Belaidi AA, Gunn AP, Wong BX, Ayton S, Appukuttan AT, Roberts BR, Duce JA, Bush AI. Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 30112699 DOI: 10.1007/s13311-018-0656-x  0.6
2018 Tamano H, Kubota M, Fujise Y, Shimaya R, Itoh R, Suzuki M, Adlard PA, Bush AI, Takeda A. Adrenergic β receptor activation in the basolateral amygdala, which is intracellular Zn-dependent, rescues amyloid β-induced attenuation of dentate gyrus LTP. Neurochemistry International. PMID 30030113 DOI: 10.1016/j.neuint.2018.07.005  0.72
2018 Beauchamp LC, Chan J, Hung LW, Padman BS, Vella LJ, Liu XM, Coleman B, Bush AI, Lazarou M, Hill AF, Jacobson L, Barnham KJ. Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease. Acta Neuropathologica Communications. 6: 57. PMID 29976255 DOI: 10.1186/s40478-018-0560-y  0.8
2018 Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, ... ... Bush AI, et al. Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease : Jad. 62: 965-992. PMID 29562546 DOI: 10.3233/JAD-171145  1
2018 Adlard PA, Bush AI. Metals and Alzheimer's Disease: How Far Have We Come in the Clinic? Journal of Alzheimer's Disease : Jad. 62: 1369-1379. PMID 29562528 DOI: 10.3233/JAD-170662  0.72
2018 McInerney MP, Volitakis I, Bush AI, Banks WA, Short JL, Nicolazzo JA. Ionophore and Biometal Modulation of P-glycoprotein Expression and Function in Human Brain Microvascular Endothelial Cells. Pharmaceutical Research. 35: 83. PMID 29508078 DOI: 10.1007/s11095-018-2377-6  0.64
2018 Takeda A, Tamano H, Hashimoto W, Kobuchi S, Suzuki H, Murakami T, Tempaku M, Koike Y, Adlard PA, Bush AI. Novel Defense by Metallothionein Induction Against Cognitive Decline: From Amyloid β-Induced Excess Znto Functional ZnDeficiency. Molecular Neurobiology. PMID 29460269 DOI: 10.1007/s12035-018-0948-5  0.72
2018 Porter T, Burnham SC, Doré V, Savage G, Bourgeat P, Begemann K, Milicic L, Ames D, Bush AI, Maruff P, Masters CL, Rowe CC, Rainey-Smith S, Martins RN, Groth D, et al. KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports. 8: 2034. PMID 29391469 DOI: 10.1038/s41598-018-20513-y  1
2018 Moreau C, Duce JA, Rascol O, Devedjian JC, Berg D, Dexter D, Cabantchik ZI, Bush AI, Devos D. Iron as a therapeutic target for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29380903 DOI: 10.1002/mds.27275  0.44
2017 Doecke JD, Rembach A, Villemagne VL, Varghese S, Rainey-Smith S, Sarros S, Evered LA, Fowler CJ, Pertile KK, Rumble RL, Trounson B, Taddei K, Laws SM, Macaulay SL, Bush AI, et al. Concordance Between Cerebrospinal Fluid Biomarkers with Alzheimer's Disease Pathology Between Three Independent Assay Platforms. Journal of Alzheimer's Disease : Jad. PMID 29171991 DOI: 10.3233/JAD-170128  1
2017 Pedrini S, Gupta VB, Hone E, Doecke J, O'Bryant S, James I, Bush AI, Rowe CC, Villemagne VL, Ames D, Masters CL, Martins RN. A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort. Scientific Reports. 7: 14057. PMID 29070909 DOI: 10.1038/s41598-017-14020-9  1
2017 Ayton S, James SA, Bush AI. Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease. Cell Chemical Biology. 24: 1192-1194. PMID 29053948 DOI: 10.1016/j.chembiol.2017.10.002  0.44
2017 Ayton S, Fazlollahi A, Bourgeat P, Raniga P, Ng A, Lim YY, Diouf I, Farquharson S, Fripp J, Ames D, Doecke J, Desmond P, Ordidge R, Masters CL, Rowe CC, ... ... Bush AI, et al. Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline. Brain : a Journal of Neurology. 140: 2112-2119. PMID 28899019 DOI: 10.1093/brain/awx137  1
2017 Masaldan S, Clatworthy SAS, Gamell C, Meggyesy PM, Rigopoulos AT, Haupt S, Haupt Y, Denoyer D, Adlard PA, Bush AI, Cater MA. Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis. Redox Biology. 14: 100-115. PMID 28888202 DOI: 10.1016/j.redox.2017.08.015  0.72
2017 Liu S, Shen Y, Shultz SR, Nguyen A, Hovens C, Adlard PA, Bush AI, Chan J, Kwan P, O'Brien TJ, Jones NC. Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice. Epilepsia. PMID 28710841 DOI: 10.1111/epi.13847  0.72
2017 Finkelstein DI, Billings JL, Adlard PA, Ayton S, Sedjahtera A, Masters CL, Wilkins S, Shackleford DM, Charman SA, Bal W, Zawisza IA, Kurowska E, Gundlach AL, Ma S, Bush AI, et al. The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease. Acta Neuropathologica Communications. 5: 53. PMID 28659169 DOI: 10.1186/s40478-017-0456-2  1
2017 Takeda A, Tamano H, Tempaku M, Sasaki M, Uematsu C, Sato S, Kanazawa H, Datki ZL, Adlard PA, Bush AI. Extracellular Zn(2+) is essential for amyloid β1-42-induced cognitive decline in the normal brain and its rescue. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28652412 DOI: 10.1523/JNEUROSCI.0954-17.2017  0.72
2017 Meng T, Cao Q, Lei P, Bush AI, Xiang Q, Su Z, He X, Rogers JT, Chiu IM, Zhang Q, Huang Y. Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway. Molecular Therapy. Nucleic Acids. 7: 439-452. PMID 28624220 DOI: 10.1016/j.omtn.2017.05.004  0.36
2017 Gupta VB, Hone E, Pedrini S, Doecke J, O'Bryant S, James I, Bush AI, Rowe CC, Villemagne VL, Ames D, Masters CL, Martins RN. Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort. Alzheimer's & Dementia (Amsterdam, Netherlands). 8: 60-72. PMID 28508031 DOI: 10.1016/j.dadm.2017.04.003  1
2017 Rita Cardoso B, Hare DJ, Lind M, McLean CA, Volitakis I, Laws SM, Masters CL, Bush AI, Roberts BR. The APOE ε4 allele is associated with lower selenium levels in the brain: implications in Alzheimer's disease. Acs Chemical Neuroscience. PMID 28453930 DOI: 10.1021/acschemneuro.7b00014  1
2017 Mukherjee S, Kapp EA, Lothian A, Roberts AM, Vasilev Y, Boughton B, Barnham KJ, Kok WM, Hutton CA, Masters CL, Bush A, Beckman JS, Dey SG, Roberts BR. Characterization and identification of dityrosine cross-linked peptides using tandem mass spectrometry. Analytical Chemistry. PMID 28453255 DOI: 10.1021/acs.analchem.7b00941  1
2017 Wang Y, Spincemaille P, Liu Z, Dimov A, Deh K, Li J, Zhang Y, Yao Y, Gillen KM, Wilman AH, Gupta A, Tsiouris AJ, Kovanlikaya I, Chiang GC, Weinsaft JW, ... ... Bush AI, et al. Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care. Journal of Magnetic Resonance Imaging : Jmri. PMID 28295954 DOI: 10.1002/jmri.25693  0.76
2017 Cardoso BR, Hare DJ, Bush AI, Li QX, Fowler CJ, Masters CL, Martins RN, Ganio K, Lothian A, Mukherjee S, Kapp EA, Roberts BR. Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Journal of Alzheimer's Disease : Jad. PMID 28222503 DOI: 10.3233/JAD-160622  1
2017 Hare DJ, Kysenius K, Paul B, Knauer B, Hutchinson RW, O'Connor C, Fryer F, Hennessey TP, Bush AI, Crouch PJ, Doble PA. Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS). Journal of Visualized Experiments : Jove. PMID 28190025 DOI: 10.3791/55042  0.48
2017 Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S. Ferroptosis and cell death mechanisms in Parkinson's disease. Neurochemistry International. PMID 28082232 DOI: 10.1016/j.neuint.2017.01.004  0.72
2017 Huuskonen MT, Tuo QZ, Loppi S, Dhungana H, Korhonen P, McInnes LE, Donnelly PS, Grubman A, Wojciechowski S, Lejavova K, Pomeshchik Y, Periviita L, Kosonen L, Giordano M, Walker FR, ... ... Bush AI, et al. The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28050710 DOI: 10.1007/s13311-016-0504-9  0.68
2016 Paul B, Hare DJ, Bishop DP, Paton C, Nguyen VT, Cole N, Niedwiecki MM, Andreozzi E, Vais A, Billings JL, Bray L, Bush AI, McColl G, Roberts BR, Adlard PA, et al. Correction: Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging. Chemical Science. 7: 6576. PMID 30123458 DOI: 10.1039/c6sc90060g  0.72
2016 Ayton S, Lei P, Mclean C, Bush AI, Finkelstein DI. Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson's substantia nigra. Signal Transduction and Targeted Therapy. 1: 16015. PMID 29263898 DOI: 10.1038/sigtrans.2016.15  0.44
2016 Lam LQ, Wong BX, Frugier T, Li QX, Collins SJ, Bush AI, Crack PJ, Duce JA. Oxidation of iron under physiologically relevant conditions in biological fluids from healthy and Alzheimer's disease subjects. Acs Chemical Neuroscience. PMID 28029772 DOI: 10.1021/acschemneuro.6b00411  0.72
2016 Roberts BR, Doecke JD, Rembach A, Yévenes LF, Fowler CJ, McLean CA, Lind M, Volitakis I, Masters CL, Bush AI, Hare DJ. Rubidium and potassium levels are altered in Alzheimer's disease brain and blood but not in cerebrospinal fluid. Acta Neuropathologica Communications. 4: 119. PMID 27842602 DOI: 10.1186/s40478-016-0390-8  1
2016 Shimoni O, Shi B, Adlard PA, Bush AI. Delivery of Fluorescent Nanoparticles to the Brain. Journal of Molecular Neuroscience : Mn. PMID 27660216 DOI: 10.1007/s12031-016-0833-5  0.72
2016 Burnham SC, Rowe CC, Baker D, Bush AI, Doecke JD, Faux NG, Laws SM, Martins RN, Maruff P, Macaulay SL, Rainey-Smith S, Savage G, Ames D, Masters CL, Wilson W, et al. Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up. Neurology. PMID 27534714 DOI: 10.1212/WNL.0000000000003094  1
2016 Scarr E, Udawela M, Greenough MA, Neo J, Suk Seo M, Money TT, Upadhyay A, Bush AI, Everall IP, Thomas EA, Dean B. Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia. Npj Schizophrenia. 2: 16002. PMID 27336053 DOI: 10.1038/npjschz.2016.2  0.48
2016 Gupta VB, Doecke JD, Hone E, Pedrini S, Laws SM, Thambisetty M, Bush AI, Rowe CC, Villemagne VL, Ames D, Masters CL, Macaulay SL, Rembach A, Rainey-Smith SR, Martins RN, et al. Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimer's & Dementia (Amsterdam, Netherlands). 3: 18-26. PMID 27239546 DOI: 10.1016/j.dadm.2015.12.001  1
2016 Hare DJ, Raven EP, Roberts BR, Bogeski M, Portbury SD, McLean CA, Masters CL, Connor JR, Bush AI, Crouch PJ, Doble PA. Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and grey matter iron distribution in Alzheimer's disease frontal cortex. Neuroimage. PMID 27233149 DOI: 10.1016/j.neuroimage.2016.05.057  1
2016 Yang PH, Zhu JX, Huang YD, Zhang XY, Lei P, Bush AI, Xiang Q, Su ZJ, Zhang QH. Human Basic Fibroblast Growth Factor Inhibits Tau Phosphorylation via the PI3K/Akt-GSK3β Signaling Pathway in a 6-Hydroxydopamine-Induced Model of Parkinson's Disease. Neuro-Degenerative Diseases. 16: 357-369. PMID 27228974 DOI: 10.1159/000445871  1
2016 James SA, Hare DJ, Jenkins NL, de Jonge MD, Bush AI, McColl G. Erratum: φXANES: In vivo imaging of metal-protein coordination environments. Scientific Reports. 6: 22684. PMID 26998588 DOI: 10.1038/srep22684  0.6
2016 Hare DJ, Faux NG, Roberts BR, Volitakis I, Martins RN, Bush AI. Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Metallomics : Integrated Biometal Science. PMID 26962965 DOI: 10.1039/c6mt00019c  1
2016 Hung YH, Walterfang M, Churilov L, Bray L, Jacobson LH, Barnham KJ, Jones NC, O'Brien TJ, Velakoulis D, Bush AI. Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 26942423 DOI: 10.1007/s13311-016-0427-5  1
2016 Xu H, Perreau VM, Dent KA, Bush AI, Finkelstein DI, Adlard PA. Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes. Journal of Alzheimer's Disease : Jad. PMID 26890748 DOI: 10.3233/JAD-150797  1
2016 James SA, Hare DJ, Jenkins NL, de Jonge MD, Bush AI, McColl G. φXANES: In vivo imaging of metal-protein coordination environments. Scientific Reports. 6: 20350. PMID 26861174 DOI: 10.1038/srep20350  0.6
2016 Manso Y, Comes G, López-Ramos JC, Belfiore M, Molinero A, Giralt M, Carrasco J, Adlard PA, Bush AI, Delgado-García JM, Hidalgo J. Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26836194 DOI: 10.3233/JAD-151025  0.72
2015 Paul B, Hare DJ, Bishop DP, Paton C, Nguyen VT, Cole N, Niedzwiecki MM, Andreozzi E, Vais A, Billings JL, Bray L, Bush AI, McColl G, Roberts BR, Adlard PA, et al. Correction: Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging. Chemical Science. 6: 6677. PMID 30123450 DOI: 10.1039/c5sc90051d  0.72
2015 Paul B, Hare DJ, Bishop DP, Paton C, Nguyen VT, Cole N, Niedwiecki MM, Andreozzi E, Vais A, Billings JL, Bray L, Bush AI, McColl G, Roberts BR, Adlard PA, et al. Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging. Chemical Science. 6: 5383-5393. PMID 29449912 DOI: 10.1039/c5sc02231b  0.72
2015 James SA, Roberts BR, Hare DJ, de Jonge MD, Birchall IE, Jenkins NL, Cherny RA, Bush AI, McColl G. Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans. Chemical Science. 6: 2952-2962. PMID 28706676 DOI: 10.1039/c5sc00233h  0.68
2015 Billings JL, Hare DJ, Nurjono M, Volitakis I, Cherny RA, Bush AI, Adlard PA, Finkelstein DI. Effects of neonatal iron feeding and chronic clioquinol administration on the parkinsonian human A53T transgenic mouse. Acs Chemical Neuroscience. PMID 26712118 DOI: 10.1021/acschemneuro.5b00305  0.72
2015 Gunn AP, Wong BX, Johanssen T, Griffith JC, Masters CL, Bush AI, Barnham KJ, Duce JA, Cherny RA. Amyloid-Beta Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization and Calcium-Influx in Neurons. The Journal of Biological Chemistry. PMID 26697885 DOI: 10.1074/jbc.M115.655183  1
2015 Dean OM, Mancuso SG, Bush AI, Copolov D, Do KQ, Cuénod M, Conus P, Rossell SL, Castle DJ, Berk M. Benefits of adjunctive N-acetylcysteine in a sub-group of clozapine-treated individuals diagnosed with schizophrenia. Psychiatry Research. PMID 26626948 DOI: 10.1016/j.psychres.2015.10.037  1
2015 Hare DJ, Jones MW, Wimmer VC, Jenkins NL, de Jonge MD, Bush AI, McColl G. High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans. Metallomics : Integrated Biometal Science. PMID 26567696 DOI: 10.1039/c5mt00288e  0.6
2015 Belaidi AA, Bush AI. Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics. Journal of Neurochemistry. PMID 26545340 DOI: 10.1111/jnc.13425  1
2015 Finkelstein DI, Hare DJ, Billings JL, Sedjahtera A, Nurjono M, Arthofer E, George S, Culvenor JG, Bush AI, Adlard PA. Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice. Acs Chemical Neuroscience. PMID 26481462 DOI: 10.1021/acschemneuro.5b00253  0.72
2015 Liang SH, Southon AG, Fraser BH, Krause-Heuer AM, Zhang B, Shoup TM, Lewis R, Volitakis I, Han Y, Greguric I, Bush AI, Vasdev N. Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer's Disease. Acs Medicinal Chemistry Letters. 6: 1025-9. PMID 26396692 DOI: 10.1021/acsmedchemlett.5b00281  1
2015 Li X, Lei P, Tuo Q, Ayton S, Li QX, Moon S, Volitakis I, Liu R, Masters CL, Finkelstein DI, Bush AI. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 862-73. PMID 26260389 DOI: 10.1007/s13311-015-0378-2  1
2015 Xu H, Gupta VB, Martins IJ, Martins RN, Fowler CJ, Bush AI, Finkelstein DI, Adlard PA. Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way. Neurobiology of Disease. PMID 26117305 DOI: 10.1016/j.nbd.2015.06.016  1
2015 Hare DJ, Arora M, Jenkins NL, Finkelstein DI, Doble PA, Bush AI. Is early-life iron exposure critical in neurodegeneration? Nature Reviews. Neurology. 11: 536-44. PMID 26100754 DOI: 10.1038/nrneurol.2015.100  0.48
2015 Cardoso BR, Roberts BR, Bush AI, Hare DJ. Selenium, selenoproteins and neurodegenerative diseases. Metallomics : Integrated Biometal Science. PMID 25996565 DOI: 10.1039/c5mt00075k  1
2015 Ayton S, Faux NG, Bush AI. Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nature Communications. 6: 6760. PMID 25988319 DOI: 10.1038/ncomms7760  1
2015 Chan J, Jones NC, Bush AI, O'Brien TJ, Kwan P. A mouse model of Alzheimer's disease displays increased susceptibility to kindling and seizure-associated death. Epilepsia. 56: e73-7. PMID 25879152 DOI: 10.1111/epi.12993  1
2015 Gupta VB, Wilson AC, Burnham S, Hone E, Pedrini S, Laws SM, Lim WL, Rembach A, Rainey-Smith S, Ames D, Cobiac L, Macaulay SL, Masters CL, Rowe CC, Bush AI, et al. Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research & Therapy. 7: 16. PMID 25859282 DOI: 10.1186/s13195-015-0105-6  1
2015 Lei P, Ayton S, Appukuttan AT, Volitakis I, Adlard PA, Finkelstein DI, Bush AI. Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse. Neurobiology of Disease. PMID 25796563 DOI: 10.1016/j.nbd.2015.03.015  1
2015 Ayton S, Lei P, Hare DJ, Duce JA, George JL, Adlard PA, McLean C, Rogers JT, Cherny RA, Finkelstein DI, Bush AI. Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3591-7. PMID 25716857 DOI: 10.1523/JNEUROSCI.3439-14.2015  1
2015 Berggren KL, Chen J, Fox J, Miller J, Dodds L, Dugas B, Vargas L, Lothian A, McAllum E, Volitakis I, Roberts B, Bush AI, Fox JH. Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease. Redox Biology. 4: 363-74. PMID 25703232 DOI: 10.1016/j.redox.2015.02.002  1
2015 Hare DJ, Doecke JD, Faux NG, Rembach A, Volitakis I, Fowler CJ, Grimm R, Doble PA, Cherny RA, Masters CL, Bush AI, Roberts BR. Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation. Acs Chemical Neuroscience. 6: 398-402. PMID 25588002 DOI: 10.1021/cn5003557  1
2015 Roberts BR, Hare DJ, McLean CA, Conquest A, Lind M, Li QX, Bush AI, Masters CL, Morganti-Kossmann MC, Frugier T. Traumatic brain injury induces elevation of Co in the human brain. Metallomics : Integrated Biometal Science. 7: 66-70. PMID 25424382 DOI: 10.1039/c4mt00258j  1
2015 Ayton S, Lei P, Bush AI. Biometals and their therapeutic implications in Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 109-20. PMID 25354461 DOI: 10.1007/s13311-014-0312-z  1
2015 Rapado-Castro M, Berk M, Venugopal K, Bush AI, Dodd S, Dean OM. Towards stage specific treatments: effects of duration of illness on therapeutic response to adjunctive treatment with N-acetyl cysteine in schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 57: 69-75. PMID 25315856 DOI: 10.1016/j.pnpbp.2014.10.002  1
2015 Robb E, Perez K, Hung LW, Masters CL, Barnham KJ, Cherny RA, Bush AI, Adlard PA, Finkelstein DI. High order W02-reactive stable oligomers of amyloid-β are produced in vivo and in vitro via dialysis and filtration of synthetic amyloid-β monomer. Journal of Alzheimer's Disease : Jad. 44: 69-78. PMID 25182735 DOI: 10.3233/JAD-132024  1
2015 Paul B, Hare DJ, Bishop DP, Paton C, Nguyen VT, Cole N, Niedwiecki MM, Andreozzi E, Vais A, Billings JL, Bray L, Bush AI, McColl G, Roberts BR, Adlard PA, et al. Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging Chemical Science. 6: 5383-5393. DOI: 10.1039/c5sc02231b  0.72
2015 James SA, Roberts BR, Hare DJ, De Jonge MD, Birchall IE, Jenkins NL, Cherny RA, Bush AI, McColl G. Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans Chemical Science. 6: 2952-2962. DOI: 10.1039/c5sc00233h  1
2015 Li X, Lei P, Tuo Q, Ayton S, Li QX, Moon S, Volitakis I, Liu R, Masters CL, Finkelstein DI, Bush AI. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau Neurotherapeutics. DOI: 10.1007/s13311-015-0378-2  1
2014 Adlard PA, Parncutt J, Lal V, James S, Hare D, Doble P, Finkelstein DI, Bush AI. Metal chaperones prevent zinc-mediated cognitive decline. Neurobiology of Disease. PMID 25549871 DOI: 10.1016/j.nbd.2014.12.012  1
2014 Takeda A, Nakamura M, Fujii H, Uematsu C, Minamino T, Adlard PA, Bush AI, Tamano H. Amyloid β-mediated Zn2+ influx into dentate granule cells transiently induces a short-term cognitive deficit. Plos One. 9: e115923. PMID 25536033 DOI: 10.1371/journal.pone.0115923  0.72
2014 Castro PA, Ramirez A, Sepúlveda FJ, Peters C, Fierro H, Waldron J, Luza S, Fuentealba J, Muñoz FJ, De Ferrari GV, Bush AI, Aguayo LG, Opazo CM. Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons. Frontiers in Aging Neuroscience. 6: 319. PMID 25520655 DOI: 10.3389/fnagi.2014.00319  1
2014 Wong BX, Tsatsanis A, Lim LQ, Adlard PA, Bush AI, Duce JA. β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin. Plos One. 9: e114174. PMID 25464026 DOI: 10.1371/journal.pone.0114174  1
2014 Adlard PA, Tran BA, Finkelstein DI, Desmond PM, Johnston LA, Bush AI, Egan GF. A review of β-amyloid neuroimaging in Alzheimer's disease. Frontiers in Neuroscience. 8: 327. PMID 25400539 DOI: 10.3389/fnins.2014.00327  1
2014 Brown BM, Bourgeat P, Peiffer JJ, Burnham S, Laws SM, Rainey-Smith SR, Bartrés-Faz D, Villemagne VL, Taddei K, Rembach A, Bush A, Ellis KA, Macaulay SL, Rowe CC, Ames D, et al. Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology. 83: 1345-52. PMID 25186863 DOI: 10.1212/WNL.0000000000000867  1
2014 Adlard PA, Li QX, McLean C, Masters CL, Bush AI, Fodero-Tavoletti M, Villemagne V, Barnham KJ. β-amyloid in biological samples: not all Aβ detection methods are created equal. Frontiers in Aging Neuroscience. 6: 203. PMID 25165449 DOI: 10.3389/fnagi.2014.00203  1
2014 Wong BX, Ayton S, Lam LQ, Lei P, Adlard PA, Bush AI, Duce JA. A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe(2+) under physiologically relevant conditions. Biochimica Et Biophysica Acta. 1840: 3299-310. PMID 25152357 DOI: 10.1016/j.bbagen.2014.08.006  1
2014 Yu M, Ryan TM, Ellis S, Bush AI, Triccas JA, Rutledge PJ, Todd MH. Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β. Metallomics : Integrated Biometal Science. 6: 1931-40. PMID 25132118 DOI: 10.1039/c4mt00122b  1
2014 Lei P, Ayton S, Moon S, Zhang Q, Volitakis I, Finkelstein DI, Bush AI. Motor and cognitive deficits in aged tau knockout mice in two background strains. Molecular Neurodegeneration. 9: 29. PMID 25124182 DOI: 10.1186/1750-1326-9-29  1
2014 Barnham KJ, Bush AI. Biological metals and metal-targeting compounds in major neurodegenerative diseases. Chemical Society Reviews. 43: 6727-49. PMID 25099276 DOI: 10.1039/c4cs00138a  1
2014 Ciccotosto GD, James SA, Altissimo M, Paterson D, Vogt S, Lai B, de Jonge MD, Howard DL, Bush AI, Cappai R. Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue. Metallomics : Integrated Biometal Science. 6: 1894-904. PMID 25098278 DOI: 10.1039/c4mt00176a  1
2014 Opazo CM, Greenough MA, Bush AI. Copper: from neurotransmission to neuroproteostasis. Frontiers in Aging Neuroscience. 6: 143. PMID 25071552 DOI: 10.3389/fnagi.2014.00143  1
2014 Lu Z, Marks E, Chen J, Moline J, Barrows L, Raisbeck M, Volitakis I, Cherny RA, Chopra V, Bush AI, Hersch S, Fox JH. Altered selenium status in Huntington's disease: neuroprotection by selenite in the N171-82Q mouse model. Neurobiology of Disease. 71: 34-42. PMID 25014023 DOI: 10.1016/j.nbd.2014.06.022  1
2014 Ayton S, Lei P, Adlard PA, Volitakis I, Cherny RA, Bush AI, Finkelstein DI. Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease. Molecular Neurodegeneration. 9: 27. PMID 25011704 DOI: 10.1186/1750-1326-9-27  1
2014 Berk M, Dean OM, Cotton SM, Jeavons S, Tanious M, Kohlmann K, Hewitt K, Moss K, Allwang C, Schapkaitz I, Robbins J, Cobb H, Ng F, Dodd S, Bush AI, et al. The efficacy of adjunctive N-acetylcysteine in major depressive disorder: a double-blind, randomized, placebo-controlled trial. The Journal of Clinical Psychiatry. 75: 628-36. PMID 25004186 DOI: 10.4088/JCP.13m08454  1
2014 Barnard ND, Bush AI, Ceccarelli A, Cooper J, de Jager CA, Erickson KI, Fraser G, Kesler S, Levin SM, Lucey B, Morris MC, Squitti R. Dietary and lifestyle guidelines for the prevention of Alzheimer's disease. Neurobiology of Aging. 35: S74-8. PMID 24913896 DOI: 10.1016/j.neurobiolaging.2014.03.033  1
2014 Rembach A, Watt AD, Wilson WJ, Rainey-Smith S, Ellis KA, Rowe CC, Villemagne VL, Macaulay SL, Bush AI, Martins RN, Ames D, Masters CL, Doecke JD. An increased neutrophil-lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation. Journal of Neuroimmunology. 273: 65-71. PMID 24907904 DOI: 10.1016/j.jneuroim.2014.05.005  1
2014 Roberts BR, Lim NK, McAllum EJ, Donnelly PS, Hare DJ, Doble PA, Turner BJ, Price KA, Lim SC, Paterson BM, Hickey JL, Rhoads TW, Williams JR, Kanninen KM, Hung LW, ... ... Bush AI, et al. Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8021-31. PMID 24899723 DOI: 10.1523/JNEUROSCI.4196-13.2014  1
2014 Wong BX, Hung YH, Bush AI, Duce JA. Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology. Frontiers in Aging Neuroscience. 6: 91. PMID 24860500 DOI: 10.3389/fnagi.2014.00091  1
2014 Moore EM, Mander AG, Ames D, Kotowicz MA, Carne RP, Brodaty H, Woodward M, Ellis KA, Bush AI, Faux NG, Watters DA. Response to comment on Moore et al. Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes care 2013;36:2981-2987. Diabetes Care. 37: e151. PMID 24855179 DOI: 10.2337/dc14-0278  0.6
2014 Rembach A, Hare DJ, Doecke JD, Burnham SC, Volitakis I, Fowler CJ, Cherny RA, McLean C, Grimm R, Martins R, Ames D, Masters CL, Bush AI, Roberts BR. Decreased serum zinc is an effect of ageing and not Alzheimer's disease. Metallomics : Integrated Biometal Science. 6: 1216-9. PMID 24676028 DOI: 10.1039/c4mt00060a  1
2014 Acevedo KM, Opazo CM, Norrish D, Challis LM, Li QX, White AR, Bush AI, Camakaris J. Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells. The Journal of Biological Chemistry. 289: 11007-19. PMID 24610780 DOI: 10.1074/jbc.M113.538710  1
2014 Ayton S, Zhang M, Roberts BR, Lam LQ, Lind M, McLean C, Bush AI, Frugier T, Crack PJ, Duce JA. Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron. Free Radical Biology & Medicine. 69: 331-7. PMID 24509156 DOI: 10.1016/j.freeradbiomed.2014.01.041  1
2014 Lim YY, Villemagne VL, Laws SM, Ames D, Pietrzak RH, Ellis KA, Harrington K, Bourgeat P, Bush AI, Martins RN, Masters CL, Rowe CC, Maruff P. Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's disease: a preliminary study. Plos One. 9: e86498. PMID 24475133 DOI: 10.1371/journal.pone.0086498  1
2014 Faux NG, Rembach A, Wiley J, Ellis KA, Ames D, Fowler CJ, Martins RN, Pertile KK, Rumble RL, Trounson B, Masters CL, Bush AI. An anemia of Alzheimer's disease. Molecular Psychiatry. 19: 1227-34. PMID 24419041 DOI: 10.1038/mp.2013.178  1
2014 Hung YH, Faux NG, Killilea DW, Yanjanin N, Firnkes S, Volitakis I, Ganio G, Walterfang M, Hastings C, Porter FD, Ory DS, Bush AI. Altered transition metal homeostasis in Niemann-Pick disease, type C1. Metallomics : Integrated Biometal Science. 6: 542-53. PMID 24343124 DOI: 10.1039/c3mt00308f  1
2014 Rembach A, Watt AD, Wilson WJ, Villemagne VL, Burnham SC, Ellis KA, Maruff P, Ames D, Rowe CC, Macaulay SL, Bush AI, Martins RN, Masters CL, Doecke JD. Plasma amyloid-β levels are significantly associated with a transition toward Alzheimer's disease as measured by cognitive decline and change in neocortical amyloid burden. Journal of Alzheimer's Disease : Jad. 40: 95-104. PMID 24334723 DOI: 10.3233/JAD-131802  1
2014 Adlard PA, Sedjahtera A, Gunawan L, Bray L, Hare D, Lear J, Doble P, Bush AI, Finkelstein DI, Cherny RA. A novel approach to rapidly prevent age-related cognitive decline. Aging Cell. 13: 351-9. PMID 24305557 DOI: 10.1111/acel.12178  1
2014 Ellis KA, Szoeke C, Bush AI, Darby D, Graham PL, Lautenschlager NT, Macaulay SL, Martins RN, Maruff P, Masters CL, McBride SJ, Pike KE, Rainey-Smith SR, Rembach A, Robertson J, et al. Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics / Ipa. 26: 543-54. PMID 24252258 DOI: 10.1017/S1041610213001956  1
2014 Moore EM, Ames D, Mander AG, Carne RP, Brodaty H, Woodward MC, Boundy K, Ellis KA, Bush AI, Faux NG, Martins RN, Masters CL, Rowe CC, Szoeke C, Watters DA. Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from three cohorts. Journal of Alzheimer's Disease : Jad. 39: 661-8. PMID 24246419 DOI: 10.3233/JAD-131265  1
2014 Squitti R, Simonelli I, Ventriglia M, Siotto M, Pasqualetti P, Rembach A, Doecke J, Bush AI. Meta-analysis of serum non-ceruloplasmin copper in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 38: 809-22. PMID 24072069 DOI: 10.3233/JAD-131247  1
2014 Burnham SC, Faux NG, Wilson W, Laws SM, Ames D, Bedo J, Bush AI, Doecke JD, Ellis KA, Head R, Jones G, Kiiveri H, Martins RN, Rembach A, Rowe CC, et al. A blood-based predictor for neocortical Aβ burden in Alzheimer's disease: results from the AIBL study. Molecular Psychiatry. 19: 519-26. PMID 23628985 DOI: 10.1038/mp.2013.40  1
2014 Rembach A, Faux NG, Watt AD, Pertile KK, Rumble RL, Trounson BO, Fowler CJ, Roberts BR, Perez KA, Li QX, Laws SM, Taddei K, Rainey-Smith S, Robertson JS, Vandijck M, ... ... Bush AI, et al. Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 53-61. PMID 23491263 DOI: 10.1016/j.jalz.2012.12.006  1
2014 Verdile G, Laws SM, Henley D, Ames D, Bush AI, Ellis KA, Faux NG, Gupta VB, Li QX, Masters CL, Pike KE, Rowe CC, Szoeke C, Taddei K, Villemagne VL, et al. Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry. 19: 69-75. PMID 23089633 DOI: 10.1038/mp.2012.147  1
2014 Hare DJ, George JL, Bray L, Volitakis I, Vais A, Ryan TM, Cherny RA, Bush AI, Masters CL, Adlard PA, Doble PA, Finkelstein DI. Errratum: The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue (Journal of Analytical Atomic Spectrometry (2013) DOI: 10.1039/C3JA50281C) Journal of Analytical Atomic Spectrometry. 29: 1726. DOI: 10.1039/C4JA90043J  1
2014 Hare DJ, Lei P, Ayton S, Roberts BR, Grimm R, George JL, Bishop DP, Beavis AD, Donovan SJ, McColl G, Volitakis I, Masters CL, Adlard PA, Cherny RA, Bush AI, et al. An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta Chemical Science. 5: 2160-2169. DOI: 10.1039/c3sc53461h  1
2014 Hare DJ, George JL, Bray L, Volitakis I, Vais A, Ryan TM, Cherny RA, Bush AI, Masters CL, Adlard PA, Doble PA, Finkelstein DI. The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue Journal of Analytical Atomic Spectrometry. 29: 565-570. DOI: 10.1039/c3ja50281c  1
2014 Hancock SM, Bush AI, Adlard PA. The clinical implications of impaired zinc signaling in the brain Zinc Signals in Cellular Functions and Disorders. 183-196. DOI: 10.1007/978-4-431-55114-0_9  1
2013 Maruff P, Lim YY, Darby D, Ellis KA, Pietrzak RH, Snyder PJ, Bush AI, Szoeke C, Schembri A, Ames D, Masters CL. Clinical utility of the cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer's disease. Bmc Psychology. 1: 30. PMID 25566378 DOI: 10.1186/2050-7283-1-30  1
2013 Squitti R, Hoogenraad T, Brewer G, Bush AI, Polimanti R. Copper status in Alzheimer's disease and other neurodegenerative disorders 2013. International Journal of Alzheimer's Disease. 2013: 838274. PMID 24455406 DOI: 10.1155/2013/838274  1
2013 Rembach A, Hare DJ, Lind M, Fowler CJ, Cherny RA, McLean C, Bush AI, Masters CL, Roberts BR. Decreased copper in Alzheimer's disease brain is predominantly in the soluble extractable fraction. International Journal of Alzheimer's Disease. 2013: 623241. PMID 24228186 DOI: 10.1155/2013/623241  1
2013 Chen J, Marks E, Lai B, Zhang Z, Duce JA, Lam LQ, Volitakis I, Bush AI, Hersch S, Fox JH. Iron accumulates in Huntington's disease neurons: protection by deferoxamine. Plos One. 8: e77023. PMID 24146952 DOI: 10.1371/journal.pone.0077023  1
2013 Hare DJ, Grubman A, Ryan TM, Lothian A, Liddell JR, Grimm R, Matsuda T, Doble PA, Cherny RA, Bush AI, White AR, Masters CL, Roberts BR. Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry. Metallomics : Integrated Biometal Science. 5: 1656-62. PMID 24132241 DOI: 10.1039/c3mt00227f  1
2013 Dean OM, Jeavons S, Malhi GS, Cotton SM, Tanious M, Kohlmann K, Hewitt K, Moss K, Allwang C, Schapkaitz I, Robbins J, Cobb H, Dodd S, Bush A, Berk M. Deserves a hearing? A case report of remitting tinnitus with N-acetyl cysteine. African Journal of Psychiatry. 16: 238, 240. PMID 24051561 DOI: http://dx.doi.org/10.4314/ajpsy.v16i4.31  1
2013 Geiser J, De Lisle RC, Finkelstein D, Adlard PA, Bush AI, Andrews GK. Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. Plos One. 8: e72543. PMID 24015258 DOI: 10.1371/journal.pone.0072543  1
2013 Moore EM, Mander AG, Ames D, Kotowicz MA, Carne RP, Brodaty H, Woodward M, Boundy K, Ellis KA, Bush AI, Faux NG, Martins R, Szoeke C, Rowe C, Watters DA, et al. Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care. 36: 2981-7. PMID 24009301 DOI: 10.2337/dc13-0229  1
2013 Hare D, Ayton S, Bush A, Lei P. A delicate balance: Iron metabolism and diseases of the brain. Frontiers in Aging Neuroscience. 5: 34. PMID 23874300 DOI: 10.3389/fnagi.2013.00034  1
2013 Lim YY, Villemagne VL, Laws SM, Ames D, Pietrzak RH, Ellis KA, Harrington KD, Bourgeat P, Salvado O, Darby D, Snyder PJ, Bush AI, Martins RN, Masters CL, Rowe CC, et al. BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of Aging. 34: 2457-64. PMID 23769397 DOI: 10.1016/j.neurobiolaging.2013.05.006  1
2013 Hung YH, Bush AI, La Fontaine S. Links between copper and cholesterol in Alzheimer's disease. Frontiers in Physiology. 4: 111. PMID 23720634 DOI: 10.3389/fphys.2013.00111  1
2013 Lim YY, Ellis KA, Harrington K, Kamer A, Pietrzak RH, Bush AI, Darby D, Martins RN, Masters CL, Rowe CC, Savage G, Szoeke C, Villemagne VL, Ames D, Maruff P. Cognitive consequences of high Aβ amyloid in mild cognitive impairment and healthy older adults: implications for early detection of Alzheimer's disease. Neuropsychology. 27: 322-32. PMID 23688214 DOI: 10.1037/a0032321  1
2013 Southon A, Greenough MA, Ganio G, Bush AI, Burke R, Camakaris J. Presenilin promotes dietary copper uptake. Plos One. 8: e62811. PMID 23667524 DOI: 10.1371/journal.pone.0062811  1
2013 Cater MA, Pearson HB, Wolyniec K, Klaver P, Bilandzic M, Paterson BM, Bush AI, Humbert PO, La Fontaine S, Donnelly PS, Haupt Y. Increasing intracellular bioavailable copper selectively targets prostate cancer cells. Acs Chemical Biology. 8: 1621-31. PMID 23656859 DOI: 10.1021/cb400198p  1
2013 Ayton S, George JL, Adlard PA, Bush AI, Cherny RA, Finkelstein DI. The effect of dopamine on MPTP-induced rotarod disability. Neuroscience Letters. 543: 105-9. PMID 23562518 DOI: 10.1016/j.neulet.2013.02.066  1
2013 Lim YY, Jaeger J, Harrington K, Ashwood T, Ellis KA, Stöffler A, Szoeke C, Lachovitzki R, Martins RN, Villemagne VL, Bush A, Masters CL, Rowe CC, Ames D, Darby D, et al. Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer's disease: results from the Australian Imaging, Biomarkers, and Lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists. 28: 320-30. PMID 23552802 DOI: 10.1093/arclin/act021  1
2013 Magalhães PV, Dean OM, Bush AI, Copolov DL, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M. A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania. The Australian and New Zealand Journal of Psychiatry. 47: 564-8. PMID 23493756 DOI: 10.1177/0004867413481631  1
2013 James SA, de Jonge MD, Howard DL, Bush AI, Paterson D, McColl G. Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans. Metallomics : Integrated Biometal Science. 5: 627-35. PMID 23459751 DOI: 10.1039/c3mt00010a  1
2013 Ayton S, Lei P, Duce JA, Wong BX, Sedjahtera A, Adlard PA, Bush AI, Finkelstein DI. Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease. Annals of Neurology. 73: 554-9. PMID 23424051 DOI: 10.1002/ana.23817  1
2013 Ellis KA, Lim YY, Harrington K, Ames D, Bush AI, Darby D, Martins RN, Masters CL, Rowe CC, Savage G, Szoeke C, Villemagne VL, Maruff P. Decline in cognitive function over 18 months in healthy older adults with high amyloid-β. Journal of Alzheimer's Disease : Jad. 34: 861-71. PMID 23302660 DOI: 10.3233/JAD-122170  1
2013 Rembach A, Doecke JD, Roberts BR, Watt AD, Faux NG, Volitakis I, Pertile KK, Rumble RL, Trounson BO, Fowler CJ, Wilson W, Ellis KA, Martins RN, Rowe CC, Villemagne VL, ... ... Bush AI, et al. Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 34: 171-82. PMID 23168449 DOI: 10.3233/JAD-121474  1
2013 Lim YY, Ellis KA, Harrington K, Pietrzak RH, Gale J, Ames D, Bush AI, Darby D, Martins RN, Masters CL, Rowe CC, Savage G, Szoeke C, Villemagne VL, Maruff P. Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-β: prodromal Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 33: 1167-76. PMID 23160011 DOI: 10.3233/JAD-121771  1
2013 Ayton S, Lei P, Bush AI. Metallostasis in Alzheimer's disease. Free Radical Biology & Medicine. 62: 76-89. PMID 23142767 DOI: 10.1016/j.freeradbiomed.2012.10.558  1
2013 Lim YY, Pietrzak RH, Ellis KA, Jaeger J, Harrington K, Ashwood T, Szoeke C, Martins RN, Bush AI, Masters CL, Rowe CC, Villemagne VL, Ames D, Darby D, Maruff P. Rapid decline in episodic memory in healthy older adults with high amyloid-β. Journal of Alzheimer's Disease : Jad. 33: 675-9. PMID 23001710 DOI: 10.3233/JAD-2012-121516  1
2013 Greenough MA, Camakaris J, Bush AI. Metal dyshomeostasis and oxidative stress in Alzheimer's disease. Neurochemistry International. 62: 540-55. PMID 22982299 DOI: 10.1016/j.neuint.2012.08.014  1
2013 Brown BM, Peiffer JJ, Taddei K, Lui JK, Laws SM, Gupta VB, Taddei T, Ward VK, Rodrigues MA, Burnham S, Rainey-Smith SR, Villemagne VL, Bush A, Ellis KA, Masters CL, et al. Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry. 18: 875-81. PMID 22889922 DOI: 10.1038/mp.2012.107  1
2013 Bush AI. The metal theory of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: S277-81. PMID 22635102 DOI: 10.3233/JAD-2012-129011  1
2013 Duce JA, Ayton S, Miller AA, Tsatsanis A, Lam LQ, Leone L, Corbin JE, Butzkueven H, Kilpatrick TJ, Rogers JT, Barnham KJ, Finkelstein DI, Bush AI. Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels. Molecular Psychiatry. 18: 245-54. PMID 22212595 DOI: 10.1038/mp.2011.168  1
2012 Cherny RA, Ayton S, Finkelstein DI, Bush AI, McColl G, Massa SM. PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease. Journal of Huntington's Disease. 1: 211-9. PMID 25063332 DOI: 10.3233/JHD-120029  1
2012 McColl G, Roberts BR, Pukala TL, Kenche VB, Roberts CM, Link CD, Ryan TM, Masters CL, Barnham KJ, Bush AI, Cherny RA. Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease. Molecular Neurodegeneration. 7: 57. PMID 23171715 DOI: 10.1186/1750-1326-7-57  1
2012 Dean OM, Bush AI, Copolov DL, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M. Effects of N-acetyl cysteine on cognitive function in bipolar disorder. Psychiatry and Clinical Neurosciences. 66: 514-7. PMID 23066769 DOI: 10.1111/j.1440-1819.2012.02392.x  1
2012 Berk M, Dean OM, Cotton SM, Gama CS, Kapczinski F, Fernandes B, Kohlmann K, Jeavons S, Hewitt K, Moss K, Allwang C, Schapkaitz I, Cobb H, Bush AI, Dodd S, et al. Maintenance N-acetyl cysteine treatment for bipolar disorder: a double-blind randomized placebo controlled trial. Bmc Medicine. 10: 91. PMID 22891797 DOI: 10.1186/1741-7015-10-91  1
2012 Doecke JD, Laws SM, Faux NG, Wilson W, Burnham SC, Lam CP, Mondal A, Bedo J, Bush AI, Brown B, De Ruyck K, Ellis KA, Fowler C, Gupta VB, Head R, et al. Blood-based protein biomarkers for diagnosis of Alzheimer disease. Archives of Neurology. 69: 1318-25. PMID 22801742 DOI: 10.1001/archneurol.2012.1282  1
2012 Manso Y, Carrasco J, Comes G, Adlard PA, Bush AI, Hidalgo J. Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease. Cellular and Molecular Life Sciences : Cmls. 69: 3665-81. PMID 22766972 DOI: 10.1007/s00018-012-1045-y  1
2012 Manso Y, Carrasco J, Comes G, Meloni G, Adlard PA, Bush AI, Vašák M, Hidalgo J. Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease. Cellular and Molecular Life Sciences : Cmls. 69: 3683-700. PMID 22722772 DOI: 10.1007/s00018-012-1047-9  1
2012 Dean OM, Bush AI, Berk M. Translating the Rosetta Stone of N-acetylcysteine. Biological Psychiatry. 71: 935-6. PMID 22579303 DOI: 10.1016/j.biopsych.2012.04.001  1
2012 Gunn AP, Roberts BR, Bush AI. Rapid generation of dityrosine cross-linked Aβ oligomers via Cu-redox cycling. Methods in Molecular Biology (Clifton, N.J.). 849: 3-10. PMID 22528079 DOI: 10.1007/978-1-61779-551-0_1  1
2012 Hung LW, Villemagne VL, Cheng L, Sherratt NA, Ayton S, White AR, Crouch PJ, Lim S, Leong SL, Wilkins S, George J, Roberts BR, Pham CL, Liu X, Chiu FC, ... ... Bush AI, et al. The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease. The Journal of Experimental Medicine. 209: 837-54. PMID 22473957 DOI: 10.1084/jem.20112285  1
2012 Gu BJ, Duce JA, Valova VA, Wong B, Bush AI, Petrou S, Wiley JS. P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. The Journal of Biological Chemistry. 287: 17318-30. PMID 22461619 DOI: 10.1074/jbc.M112.340885  1
2012 Adlard PA, Bush AI. Metal chaperones: a holistic approach to the treatment of Alzheimer's disease. Frontiers in Psychiatry. 3: 15. PMID 22403554 DOI: 10.3389/fpsyt.2012.00015  1
2012 McColl G, James SA, Mayo S, Howard DL, Ryan CG, Kirkham R, Moorhead GF, Paterson D, de Jonge MD, Bush AI. Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese. Plos One. 7: e32685. PMID 22393436 DOI: 10.1371/journal.pone.0032685  1
2012 Rosas HD, Chen YI, Doros G, Salat DH, Chen NK, Kwong KK, Bush A, Fox J, Hersch SM. Alterations in brain transition metals in Huntington disease: an evolving and intricate story. Archives of Neurology. 69: 887-93. PMID 22393169 DOI: 10.1001/archneurol.2011.2945  1
2012 Lei P, Ayton S, Finkelstein DI, Spoerri L, Ciccotosto GD, Wright DK, Wong BX, Adlard PA, Cherny RA, Lam LQ, Roberts BR, Volitakis I, Egan GF, McLean CA, Cappai R, ... ... Bush AI, et al. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nature Medicine. 18: 291-5. PMID 22286308 DOI: 10.1038/nm.2613  1
2012 Magalhães PV, Dean OM, Bush AI, Copolov DL, Weisinger D, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M. Systemic illness moderates the impact of N-acetyl cysteine in bipolar disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 37: 132-5. PMID 22212173 DOI: 10.1016/j.pnpbp.2011.11.011  1
2012 Roberts BR, Ryan TM, Bush AI, Masters CL, Duce JA. The role of metallobiology and amyloid-β peptides in Alzheimer's disease. Journal of Neurochemistry. 120: 149-66. PMID 22121980 DOI: 10.1111/j.1471-4159.2011.07500.x  1
2012 Li H, Evin G, Hill AF, Hung YH, Bush AI, Garner B. Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues. Clinical Science (London, England : 1979). 122: 409-19. PMID 22103431 DOI: 10.1042/CS20110257  1
2012 James SA, Volitakis I, Adlard PA, Duce JA, Masters CL, Cherny RA, Bush AI. Elevated labile Cu is associated with oxidative pathology in Alzheimer disease. Free Radical Biology & Medicine. 52: 298-302. PMID 22080049 DOI: 10.1016/j.freeradbiomed.2011.10.446  1
2012 Sona A, Zhang P, Ames D, Bush AI, Lautenschlager NT, Martins RN, Masters CL, Rowe CC, Szoeke C, Taddei K, Ellis KA. Predictors of rapid cognitive decline in Alzheimer's disease: results from the Australian imaging, biomarkers and lifestyle (AIBL) study of ageing. International Psychogeriatrics / Ipa. 24: 197-204. PMID 21749739 DOI: 10.1017/S1041610211001335  1
2011 Magalhães PV, Dean OM, Bush AI, Copolov DL, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M. N-acetylcysteine for major depressive episodes in bipolar disorder. Revista Brasileira De Psiquiatria (SãO Paulo, Brazil : 1999). 33: 374-8. PMID 22189927 DOI: 10.1590/S1516-44462011000400011  1
2011 Kaden D, Bush AI, Danzeisen R, Bayer TA, Multhaup G. Disturbed copper bioavailability in Alzheimer's disease. International Journal of Alzheimer's Disease. 2011: 345614. PMID 22145082 DOI: 10.4061/2011/345614  1
2011 Sensi SL, Paoletti P, Koh JY, Aizenman E, Bush AI, Hershfinkel M. The neurophysiology and pathology of brain zinc. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16076-85. PMID 22072659 DOI: 10.1523/JNEUROSCI.3454-11.2011  1
2011 Faux NG, Ellis KA, Porter L, Fowler CJ, Laws SM, Martins RN, Pertile KK, Rembach A, Rowe CC, Rumble RL, Szoeke C, Taddei K, Taddei T, Trounson BO, Villemagne VL, ... ... Bush AI, et al. Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study. Journal of Alzheimer's Disease : Jad. 27: 909-22. PMID 21891867 DOI: 10.3233/JAD-2011-110752  1
2011 Manso Y, Comes G, Hidalgo J, Bush AI, Adlard PA. Copper modulation as a therapy for Alzheimer's disease? International Journal of Alzheimer's Disease. 2011: 370345. PMID 21876828 DOI: 10.4061/2011/370345  1
2011 Crouch PJ, Savva MS, Hung LW, Donnelly PS, Mot AI, Parker SJ, Greenough MA, Volitakis I, Adlard PA, Cherny RA, Masters CL, Bush AI, Barnham KJ, White AR. The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity. Journal of Neurochemistry. 119: 220-30. PMID 21797865 DOI: 10.1111/j.1471-4159.2011.07402.x  1
2011 Berk M, Dean O, Cotton SM, Gama CS, Kapczinski F, Fernandes BS, Kohlmann K, Jeavons S, Hewitt K, Allwang C, Cobb H, Bush AI, Schapkaitz I, Dodd S, Malhi GS. The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial. Journal of Affective Disorders. 135: 389-94. PMID 21719110 DOI: 10.1016/j.jad.2011.06.005  1
2011 Lei P, Ayton S, Bush AI, Adlard PA. GSK-3 in Neurodegenerative Diseases. International Journal of Alzheimer's Disease. 2011: 189246. PMID 21629738 DOI: 10.4061/2011/189246  1
2011 Dean OM, van den Buuse M, Berk M, Copolov DL, Mavros C, Bush AI. N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder. Neuroscience Letters. 499: 149-53. PMID 21621586 DOI: 10.1016/j.neulet.2011.05.027  1
2011 Fox JH, Connor T, Stiles M, Kama J, Lu Z, Dorsey K, Lieberman G, Liebermann G, Sapp E, Cherny RA, Banks M, Volitakis I, DiFiglia M, Berezovska O, Bush AI, et al. Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein. The Journal of Biological Chemistry. 286: 18320-30. PMID 21454633 DOI: 10.1074/jbc.M110.199448  1
2011 Gupta VB, Laws SM, Villemagne VL, Ames D, Bush AI, Ellis KA, Lui JK, Masters C, Rowe CC, Szoeke C, Taddei K, Martins RN. Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging. Neurology. 76: 1091-8. PMID 21422459 DOI: 10.1212/WNL.0b013e318211c352  1
2011 Adlard PA, Bica L, White AR, Nurjono M, Filiz G, Crouch PJ, Donnelly PS, Cappai R, Finkelstein DI, Bush AI. Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. Plos One. 6: e17669. PMID 21412423 DOI: 10.1371/journal.pone.0017669  1
2011 Sittironnarit G, Ames D, Bush AI, Faux N, Flicker L, Foster J, Hilmer S, Lautenschlager NT, Maruff P, Masters CL, Martins RN, Rowe C, Szoeke C, Ellis KA. Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders. 31: 173-8. PMID 21389718 DOI: 10.1159/000325171  1
2011 Greenough MA, Volitakis I, Li QX, Laughton K, Evin G, Ho M, Dalziel AH, Camakaris J, Bush AI. Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity. The Journal of Biological Chemistry. 286: 9776-86. PMID 21239495 DOI: 10.1074/jbc.M110.163964  1
2011 Acevedo KM, Hung YH, Dalziel AH, Li QX, Laughton K, Wikhe K, Rembach A, Roberts B, Masters CL, Bush AI, Camakaris J. Copper promotes the trafficking of the amyloid precursor protein. The Journal of Biological Chemistry. 286: 8252-62. PMID 21177866 DOI: 10.1074/jbc.M110.128512  1
2011 Adlard PA, Bush AI. The plasma membrane redox system in Alzheimer's disease. Experimental Neurology. 228: 9-14. PMID 21168407 DOI: 10.1016/j.expneurol.2010.12.009  1
2011 Berk M, Munib A, Dean O, Malhi GS, Kohlmann K, Schapkaitz I, Jeavons S, Katz F, Anderson-Hunt M, Conus P, Hanna B, Otmar R, Ng F, Copolov DL, Bush AI. Qualitative methods in early-phase drug trials: broadening the scope of data and methods from an RCT of N-acetylcysteine in schizophrenia. The Journal of Clinical Psychiatry. 72: 909-13. PMID 20868637 DOI: 10.4088/JCP.09m05741yel  1
2011 Magalhães PV, Dean OM, Bush AI, Copolov DL, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M. N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial. Journal of Affective Disorders. 129: 317-20. PMID 20800897 DOI: 10.1016/j.jad.2010.08.001  1
2011 Duce JA, Bush AI, Adlard PA. Role of amyloid-β-metal interactions in Alzheimers disease Future Neurology. 6: 641-659. DOI: 10.2217/fnl.11.43  1
2011 Magalhães PV, Dean OM, Bush AI, Copolov DL, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M. Dimensions of improvement in a clinical trial of N-acetyl cysteine for bipolar disorder Acta Neuropsychiatrica. 23: 87-88. DOI: 10.1111/j.1601-5215.2011.00530.x  1
2011 Fox JH, Connor T, Stiles M, Kama J, Lu Z, Dorsey K, Lieberman G, Sapp E, Cherny RA, Banks M, Volitakis I, DiFiglia M, Berezovska O, Bush AI, Hersch SM. Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein (Journal of Biological Chemistry (2011) 286, (18320-18330)) Journal of Biological Chemistry. 286: 27068. DOI: 10.1074/jbc.A110.199448  1
2010 Norgate M, Southon A, Greenough M, Cater M, Farlow A, Batterham P, Bush AI, Subramaniam VN, Burke R, Camakaris J. Syntaxin 5 is required for copper homeostasis in Drosophila and mammals. Plos One. 5: e14303. PMID 21188142 DOI: 10.1371/journal.pone.0014303  1
2010 Hare DJ, George JL, Grimm R, Wilkins S, Adlard PA, Cherny RA, Bush AI, Finkelstein DI, Doble P. Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain. Metallomics : Integrated Biometal Science. 2: 745-53. PMID 21072366 DOI: 10.1039/c0mt00039f  1
2010 Choy KH, Dean O, Berk M, Bush AI, van den Buuse M. Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats. European Journal of Pharmacology. 649: 224-8. PMID 20868666 DOI: 10.1016/j.ejphar.2010.09.035  1
2010 Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, ... ... Bush AI, et al. Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 142: 857-67. PMID 20817278 DOI: 10.1016/j.cell.2010.08.014  1
2010 Dean O, Bush AI, Berk M, Copolov DL, van den Buuse M. Interaction of glutathione depletion and psychotropic drug treatment in prepulse inhibition in rats and mice. Pharmacology, Biochemistry, and Behavior. 97: 293-300. PMID 20816888 DOI: 10.1016/j.pbb.2010.08.013  1
2010 McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metabolism. 12: 260-72. PMID 20816092 DOI: 10.1016/j.cmet.2010.08.004  1
2010 Lei P, Ayton S, Finkelstein DI, Adlard PA, Masters CL, Bush AI. Tau protein: relevance to Parkinson's disease. The International Journal of Biochemistry & Cell Biology. 42: 1775-8. PMID 20678581 DOI: 10.1016/j.biocel.2010.07.016  1
2010 Zheng Z, White C, Lee J, Peterson TS, Bush AI, Sun GY, Weisman GA, Petris MJ. Altered microglial copper homeostasis in a mouse model of Alzheimer's disease. Journal of Neurochemistry. 114: 1630-8. PMID 20626553 DOI: 10.1111/j.1471-4159.2010.06888.x  1
2010 Lee JY, Cho E, Kim TY, Kim DK, Palmiter RD, Volitakis I, Kim JS, Bush AI, Koh JY. Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 23: 1085-95. PMID 20556483 DOI: 10.1007/s10534-010-9354-9  1
2010 Duce JA, Bush AI. Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics. Progress in Neurobiology. 92: 1-18. PMID 20444428 DOI: 10.1016/j.pneurobio.2010.04.003  1
2010 Lui JK, Laws SM, Li QX, Villemagne VL, Ames D, Brown B, Bush AI, De Ruyck K, Dromey J, Ellis KA, Faux NG, Foster J, Fowler C, Gupta V, Hudson P, et al. Plasma amyloid-beta as a biomarker in Alzheimer's disease: the AIBL study of aging. Journal of Alzheimer's Disease : Jad. 20: 1233-42. PMID 20413897 DOI: 10.3233/JAD-2010-090249  1
2010 Perreau VM, Orchard S, Adlard PA, Bellingham SA, Cappai R, Ciccotosto GD, Cowie TF, Crouch PJ, Duce JA, Evin G, Faux NG, Hill AF, Hung YH, James SA, Li QX, ... ... Bush AI, et al. A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease. Proteomics. 10: 2377-95. PMID 20391539 DOI: 10.1002/pmic.200900773  1
2010 Faux NG, Ritchie CW, Gunn A, Rembach A, Tsatsanis A, Bedo J, Harrison J, Lannfelt L, Blennow K, Zetterberg H, Ingelsson M, Masters CL, Tanzi RE, Cummings JL, Herd CM, ... Bush AI, et al. PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. Journal of Alzheimer's Disease : Jad. 20: 509-16. PMID 20164561 DOI: 10.3233/JAD-2010-1390  1
2010 Bush AI. Kalzium ist nicht alles. Neuron. 65: 143-4. PMID 20152120 DOI: 10.1016/j.neuron.2010.01.015  1
2010 Adlard PA, Parncutt JM, Finkelstein DI, Bush AI. Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1631-6. PMID 20130173 DOI: 10.1523/JNEUROSCI.5255-09.2010  1
2010 Boon WC, van den Buuse M, Wegener N, Martin S, Chua HK, Bush AI, Masters CL, Adlard PA, Li QX. Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Abeta-bearing fragment is associated with reduced NMDA receptor density. Behavioural Brain Research. 209: 27-35. PMID 20085783 DOI: 10.1016/j.bbr.2010.01.013  1
2010 Kishigami H, Nagano S, Bush AI, Sakoda S. Monomerized Cu, Zn-superoxide dismutase induces oxidative stress through aberrant Cu binding. Free Radical Biology & Medicine. 48: 945-52. PMID 20079423 DOI: 10.1016/j.freeradbiomed.2010.01.008  1
2010 Haeffner F, Barnham KJ, Bush AI, Brinck T. Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease: a DFT study. Journal of Molecular Modeling. 16: 1103-8. PMID 19924451 DOI: 10.1007/s00894-009-0619-6  1
2010 Baum L, Chan IH, Cheung SK, Goggins WB, Mok V, Lam L, Leung V, Hui E, Ng C, Woo J, Chiu HF, Zee BC, Cheng W, Chan MH, Szeto S, ... ... Bush AI, et al. Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 23: 173-9. PMID 19911117 DOI: 10.1007/s10534-009-9277-5  1
2010 Hung YH, Bush AI, Cherny RA. Copper in the brain and Alzheimer's disease. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 61-76. PMID 19862561 DOI: 10.1007/s00775-009-0600-y  1
2010 Finkelstein DI, Lynch T, Wilkins S, Cherny RA, Bush AI. Metals, Oxidative Stress, and Brain Biology Encyclopedia of Stress. 724-726. DOI: 10.1016/B978-012373947-6.00555-9  1
2010 Roberts BR, Bush AI. Role of Metals in Alzheimer Disease Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 543-558. DOI: 10.1002/9780470572702.ch24  1
2009 Bernardo M, Dodd S, Gama CS, Copolov DL, Dean O, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Bush AI, Berk M. Effects of N-acetylcysteine on substance use in bipolar disorder: A randomised placebo-controlled clinical trial. Acta Neuropsychiatrica. 21: 285-91. PMID 25384734 DOI: 10.1111/j.1601-5215.2009.00397.x  1
2009 Sensi SL, Paoletti P, Bush AI, Sekler I. Zinc in the physiology and pathology of the CNS. Nature Reviews. Neuroscience. 10: 780-91. PMID 19826435 DOI: 10.1038/nrn2734  1
2009 George JL, Mok S, Moses D, Wilkins S, Bush AI, Cherny RA, Finkelstein DI. Targeting the progression of Parkinson's disease. Current Neuropharmacology. 7: 9-36. PMID 19721815 DOI: 10.2174/157015909787602814  1
2009 Dean OM, van den Buuse M, Bush AI, Copolov DL, Ng F, Dodd S, Berk M. A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice. Current Medicinal Chemistry. 16: 2965-76. PMID 19689277 DOI: 10.2174/092986709788803060  1
2009 McColl G, Roberts BR, Gunn AP, Perez KA, Tew DJ, Masters CL, Barnham KJ, Cherny RA, Bush AI. The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42. The Journal of Biological Chemistry. 284: 22697-702. PMID 19574211 DOI: 10.1074/jbc.C109.028514  1
2009 Hung YH, Robb EL, Volitakis I, Ho M, Evin G, Li QX, Culvenor JG, Masters CL, Cherny RA, Bush AI. Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease. The Journal of Biological Chemistry. 284: 21899-907. PMID 19542222 DOI: 10.1074/jbc.M109.019521  1
2009 Adlard PA, James SA, Bush AI, Masters CL. beta-Amyloid as a molecular therapeutic target in Alzheimer's disease. Drugs of Today (Barcelona, Spain : 1998). 45: 293-304. PMID 19499094 DOI: 10.1358/dot.2009.45.4.1353853  1
2009 Smidt K, Jessen N, Petersen AB, Larsen A, Magnusson N, Jeppesen JB, Stoltenberg M, Culvenor JG, Tsatsanis A, Brock B, Schmitz O, Wogensen L, Bush AI, Rungby J. SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress. Plos One. 4: e5684. PMID 19492079 DOI: 10.1371/journal.pone.0005684  1
2009 Ellis KA, Bush AI, Darby D, De Fazio D, Foster J, Hudson P, Lautenschlager NT, Lenzo N, Martins RN, Maruff P, Masters C, Milner A, Pike K, Rowe C, Savage G, et al. The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. International Psychogeriatrics / Ipa. 21: 672-87. PMID 19470201 DOI: 10.1017/S1041610209009405  1
2009 Maynard CJ, Cappai R, Volitakis I, Laughton KM, Masters CL, Bush AI, Li QX. Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice. Cellular and Molecular Neurobiology. 29: 757-67. PMID 19381799 DOI: 10.1007/s10571-009-9401-7  1
2009 White C, Kambe T, Fulcher YG, Sachdev SW, Bush AI, Fritsche K, Lee J, Quinn TP, Petris MJ. Copper transport into the secretory pathway is regulated by oxygen in macrophages. Journal of Cell Science. 122: 1315-21. PMID 19351718 DOI: 10.1242/jcs.043216  1
2009 Minniti AN, Rebolledo DL, Grez PM, Fadic R, Aldunate R, Volitakis I, Cherny RA, Opazo C, Masters C, Bush AI, Inestrosa NC. Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification. Molecular Neurodegeneration. 4: 2. PMID 19126228 DOI: 10.1186/1750-1326-4-2  1
2009 Crouch PJ, Hung LW, Adlard PA, Cortes M, Lal V, Filiz G, Perez KA, Nurjono M, Caragounis A, Du T, Laughton K, Volitakis I, Bush AI, Li QX, Masters CL, et al. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 106: 381-6. PMID 19122148 DOI: 10.1073/pnas.0809057106  1
2009 Dean O, Bush AI, Berk M, Copolov DL, van den Buuse M. Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice. Behavioural Brain Research. 198: 258-62. PMID 19061918 DOI: 10.1016/j.bbr.2008.11.017  1
2009 Grasso G, Bush AI, D'Agata R, Rizzarelli E, Spoto G. Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme. European Biophysics Journal : Ebj. 38: 407-14. PMID 19048247 DOI: 10.1007/s00249-008-0384-y  1
2009 Biran Y, Masters CL, Barnham KJ, Bush AI, Adlard PA. Pharmacotherapeutic targets in Alzheimer's disease. Journal of Cellular and Molecular Medicine. 13: 61-86. PMID 19040415 DOI: 10.1111/j.1582-4934.2008.00595.x  1
2009 Strozyk D, Launer LJ, Adlard PA, Cherny RA, Tsatsanis A, Volitakis I, Blennow K, Petrovitch H, White LR, Bush AI. Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid. Neurobiology of Aging. 30: 1069-77. PMID 18068270 DOI: 10.1016/j.neurobiolaging.2007.10.012  1
2009 Hare D, Reedy B, Grimm R, Wilkins S, Volitakis I, George JL, Cherny RA, Bush AI, Finkelstein DI, Doble P. Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine induced Parkinsonism mouse models Metallomics. 1: 53-58. DOI: 10.1039/b816188g  1
2008 Rogers JT, Bush AI, Cho HH, Smith DH, Thomson AM, Friedlich AL, Lahiri DK, Leedman PJ, Huang X, Cahill CM. Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease. Biochemical Society Transactions. 36: 1282-7. PMID 19021541 DOI: 10.1042/BST0361282  1
2008 Bush AI. Drug development based on the metals hypothesis of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 15: 223-40. PMID 18953111  1
2008 Wu WH, Lei P, Liu Q, Hu J, Gunn AP, Chen MS, Rui YF, Su XY, Xie ZP, Zhao YF, Bush AI, Li YM. Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents. The Journal of Biological Chemistry. 283: 31657-64. PMID 18728006 DOI: 10.1074/jbc.M804722200  1
2008 Lannfelt L, Blennow K, Zetterberg H, Batsman S, Ames D, Harrison J, Masters CL, Targum S, Bush AI, Murdoch R, Wilson J, Ritchie CW. Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial. The Lancet. Neurology. 7: 779-86. PMID 18672400 DOI: 10.1016/S1474-4422(08)70167-4  1
2008 Bush AI, Tanzi RE. Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 421-32. PMID 18625454 DOI: 10.1016/j.nurt.2008.05.001  1
2008 Adlard PA, Cherny RA, Finkelstein DI, Gautier E, Robb E, Cortes M, Volitakis I, Liu X, Smith JP, Perez K, Laughton K, Li QX, Charman SA, Nicolazzo JA, Wilkins S, ... ... Bush AI, et al. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron. 59: 43-55. PMID 18614028 DOI: 10.1016/j.neuron.2008.06.018  1
2008 Berk M, Ng F, Dean O, Dodd S, Bush AI. Glutathione: a novel treatment target in psychiatry. Trends in Pharmacological Sciences. 29: 346-51. PMID 18538422 DOI: 10.1016/j.tips.2008.05.001  1
2008 Berk M, Copolov DL, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Bush AI. N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial. Biological Psychiatry. 64: 468-75. PMID 18534556 DOI: 10.1016/j.biopsych.2008.04.022  1
2008 Barnham KJ, Kenche VB, Ciccotosto GD, Smith DP, Tew DJ, Liu X, Perez K, Cranston GA, Johanssen TJ, Volitakis I, Bush AI, Masters CL, White AR, Smith JP, Cherny RA, et al. Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 6813-8. PMID 18463291 DOI: 10.1073/pnas.0800712105  1
2008 Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Judd F, Katz F, Katz P, Ording-Jespersen S, Little J, Conus P, Cuenod M, Do KQ, ... Bush AI, et al. N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial. Biological Psychiatry. 64: 361-8. PMID 18436195 DOI: 10.1016/j.biopsych.2008.03.004  1
2008 Du T, La Fontaine SL, Abdo M, Bellingham SA, Greenough M, Volitakis I, Cherny RA, Bush AI, Hudson PJ, Camakaris J, Mercer JF, Crouch PJ, Masters CL, Perreau VM, White AR. Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays. Proteomics. 8: 1819-31. PMID 18384105 DOI: 10.1002/pmic.200700895  1
2008 Barnham KJ, Bush AI. Metals in Alzheimer's and Parkinson's diseases. Current Opinion in Chemical Biology. 12: 222-8. PMID 18342639 DOI: 10.1016/j.cbpa.2008.02.019  1
2008 Cater MA, McInnes KT, Li QX, Volitakis I, La Fontaine S, Mercer JF, Bush AI. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms. The Biochemical Journal. 412: 141-52. PMID 18248325 DOI: 10.1042/BJ20080103  1
2008 Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 11: 851-76. PMID 18205981 DOI: 10.1017/S1461145707008401  1
2008 Colvin RA, Bush AI, Volitakis I, Fontaine CP, Thomas D, Kikuchi K, Holmes WR. Insights into Zn2+ homeostasis in neurons from experimental and modeling studies. American Journal of Physiology. Cell Physiology. 294: C726-42. PMID 18184873 DOI: 10.1152/ajpcell.00541.2007  1
2008 Lavoie S, Murray MM, Deppen P, Knyazeva MG, Berk M, Boulat O, Bovet P, Bush AI, Conus P, Copolov D, Fornari E, Meuli R, Solida A, Vianin P, Cuénod M, et al. Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2187-99. PMID 18004285 DOI: 10.1038/sj.npp.1301624  1
2008 Nagano S, Bush AI. Sensitive, selective, and irreversible inhibition of cyclooxygenase-2 activity by copper. Chemmedchem. 3: 223-5. PMID 18000939 DOI: 10.1002/cmdc.200700217  1
2008 Bush AI, Curtain CC. Twenty years of metallo-neurobiology: where to now? European Biophysics Journal : Ebj. 37: 241-5. PMID 17994233 DOI: 10.1007/s00249-007-0228-1  1
2008 Crouch PJ, Harding SM, White AR, Camakaris J, Bush AI, Masters CL. Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease. The International Journal of Biochemistry & Cell Biology. 40: 181-98. PMID 17804276 DOI: 10.1016/j.biocel.2007.07.013  1
2007 Stoltenberg M, Bush AI, Bach G, Smidt K, Larsen A, Rungby J, Lund S, Doering P, Danscher G. Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency. Neuroscience. 150: 357-69. PMID 17949919 DOI: 10.1016/j.neuroscience.2007.09.025  1
2007 Crouch PJ, Cimdins K, Duce JA, Bush AI, Trounce IA. Mitochondria in aging and Alzheimer's disease. Rejuvenation Research. 10: 349-57. PMID 17708691 DOI: 10.1089/rej.2007.0592  1
2007 Crouch PJ, White AR, Bush AI. The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease. The Febs Journal. 274: 3775-83. PMID 17617225 DOI: 10.1111/j.1742-4658.2007.05918.x  1
2007 Melov S, Adlard PA, Morten K, Johnson F, Golden TR, Hinerfeld D, Schilling B, Mavros C, Masters CL, Volitakis I, Li QX, Laughton K, Hubbard A, Cherny RA, Gibson B, ... Bush AI, et al. Mitochondrial oxidative stress causes hyperphosphorylation of tau. Plos One. 2: e536. PMID 17579710 DOI: 10.1371/journal.pone.0000536  1
2007 Watanabe S, Nagano S, Duce J, Kiaei M, Li QX, Tucker SM, Tiwari A, Brown RH, Beal MF, Hayward LJ, Culotta VC, Yoshihara S, Sakoda S, Bush AI. Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis. Free Radical Biology & Medicine. 42: 1534-42. PMID 17448900 DOI: 10.1016/j.freeradbiomed.2007.02.004  1
2007 Fox JH, Kama JA, Lieberman G, Chopra R, Dorsey K, Chopra V, Volitakis I, Cherny RA, Bush AI, Hersch S. Mechanisms of copper ion mediated Huntington's disease progression. Plos One. 2: e334. PMID 17396163 DOI: 10.1371/journal.pone.0000334  1
2007 Adlard PA, Bush AI. Metal ions and Alzheimer's disease Interaction Between Neurons and Glia in Aging and Disease. 333-361. DOI: 10.1007/978-0-387-70830-0_15  1
2007 Glabe C, Bush AI. Aβ structure and aggregation Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 113-131. DOI: 10.1007/978-0-387-35135-3_7  1
2006 Crouch PJ, Barnham KJ, Bush AI, White AR. Therapeutic treatments for Alzheimer's disease based on metal bioavailability. Drug News & Perspectives. 19: 469-74. PMID 17160147 DOI: 10.1358/dnp.2006.19.8.1021492  1
2006 Adlard PA, Bush AI. Metals and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 10: 145-63. PMID 17119284  1
2006 Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Current Alzheimer Research. 3: 221-7. PMID 16842099 DOI: 10.2174/156720506777632835  1
2006 Religa D, Strozyk D, Cherny RA, Volitakis I, Haroutunian V, Winblad B, Naslund J, Bush AI. Elevated cortical zinc in Alzheimer disease. Neurology. 67: 69-75. PMID 16832080 DOI: 10.1212/01.wnl.0000223644.08653.b5  1
2006 White AR, Barnham KJ, Bush AI. Metal homeostasis in Alzheimer's disease. Expert Review of Neurotherapeutics. 6: 711-22. PMID 16734519 DOI: 10.1586/14737175.6.5.711  0.8
2006 White AR, Du T, Laughton KM, Volitakis I, Sharples RA, Xilinas ME, Hoke DE, Holsinger RM, Evin G, Cherny RA, Hill AF, Barnham KJ, Li QX, Bush AI, Masters CL. Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. The Journal of Biological Chemistry. 281: 17670-80. PMID 16648635 DOI: 10.1074/jbc.M602487200  1
2006 Smith DP, Smith DG, Curtain CC, Boas JF, Pilbrow JR, Ciccotosto GD, Lau TL, Tew DJ, Perez K, Wade JD, Bush AI, Drew SC, Separovic F, Masters CL, Cappai R, et al. Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. The Journal of Biological Chemistry. 281: 15145-54. PMID 16595673 DOI: 10.1074/jbc.M600417200  1
2006 Maynard CJ, Cappai R, Volitakis I, Cherny RA, Masters CL, Li QX, Bush AI. Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology. Journal of Inorganic Biochemistry. 100: 952-62. PMID 16574231 DOI: 10.1016/j.jinorgbio.2006.02.010  1
2006 Opazo C, Luza S, Villemagne VL, Volitakis I, Rowe C, Barnham KJ, Strozyk D, Masters CL, Cherny RA, Bush AI. Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease. Aging Cell. 5: 69-79. PMID 16441845 DOI: 10.1111/j.1474-9726.2006.00196.x  1
2005 Haeffner F, Smith DG, Barnham KJ, Bush AI. Model studies of cholesterol and ascorbate oxidation by copper complexes: relevance to Alzheimer's disease beta-amyloid metallochemistry. Journal of Inorganic Biochemistry. 99: 2403-22. PMID 16271394 DOI: 10.1016/j.jinorgbio.2005.09.011  0.8
2005 Siddiq A, Ayoub IA, Chavez JC, Aminova L, Shah S, LaManna JC, Patton SM, Connor JR, Cherny RA, Volitakis I, Bush AI, Langsetmo I, Seeley T, Gunzler V, Ratan RR. Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. The Journal of Biological Chemistry. 280: 41732-43. PMID 16227210 DOI: 10.1074/jbc.M504963200  1
2005 Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. The Journal of Clinical Investigation. 115: 2556-63. PMID 16127459 DOI: 10.1172/JCI23610  1
2005 Maynard CJ, Bush AI, Masters CL, Cappai R, Li QX. Metals and amyloid-beta in Alzheimer's disease. International Journal of Experimental Pathology. 86: 147-59. PMID 15910549 DOI: 10.1111/j.0959-9673.2005.00434.x  1
2005 Frederickson CJ, Koh JY, Bush AI. The neurobiology of zinc in health and disease. Nature Reviews. Neuroscience. 6: 449-62. PMID 15891778 DOI: 10.1038/nrn1671  1
2005 Cuajungco MP, Frederickson CJ, Bush AI. Amyloid-beta metal interaction and metal chelation. Sub-Cellular Biochemistry. 38: 235-54. PMID 15709482  1
2005 Tickler AK, Smith DG, Ciccotosto GD, Tew DJ, Curtain CC, Carrington D, Masters CL, Bush AI, Cherny RA, Cappai R, Wade JD, Barnham KJ. Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity. The Journal of Biological Chemistry. 280: 13355-63. PMID 15668252 DOI: 10.1074/jbc.M414178200  1
2005 Ali FE, Separovic F, Barrow CJ, Cherny RA, Fraser F, Bush AI, Masters CL, Barnham KJ. Methionine regulates copper/hydrogen peroxide oxidation products of Abeta. Journal of Peptide Science : An Official Publication of the European Peptide Society. 11: 353-60. PMID 15635660 DOI: 10.1002/psc.626  1
2005 Melov S, Wolf N, Strozyk D, Doctrow SR, Bush AI. Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radical Biology & Medicine. 38: 258-61. PMID 15607908 DOI: 10.1016/j.freeradbiomed.2004.10.023  0.36
2004 Venti A, Giordano T, Eder P, Bush AI, Lahiri DK, Greig NH, Rogers JT. The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. Annals of the New York Academy of Sciences. 1035: 34-48. PMID 15681799 DOI: 10.1196/annals.1332.003  1
2004 Dedeoglu A, Cormier K, Payton S, Tseitlin KA, Kremsky JN, Lai L, Li X, Moir RD, Tanzi RE, Bush AI, Kowall NW, Rogers JT, Huang X. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Experimental Gerontology. 39: 1641-9. PMID 15582280 DOI: 10.1016/j.exger.2004.08.016  1
2004 Huang X, Atwood CS, Moir RD, Hartshorn MA, Tanzi RE, Bush AI. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 954-60. PMID 15578276 DOI: 10.1007/s00775-004-0602-8  1
2004 Ritchie CW, Bush AI, Masters CL. Metal-protein attenuating compounds and Alzheimer's disease. Expert Opinion On Investigational Drugs. 13: 1585-92. PMID 15566316 DOI: 10.1517/13543784.13.12.1585  1
2004 Kiaei M, Bush AI, Morrison BM, Morrison JH, Cherny RA, Volitakis I, Beal MF, Gordon JW. Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7945-50. PMID 15356208 DOI: 10.1523/JNEUROSCI.2000-04.2004  1
2004 Cerpa WF, Barría MI, Chacón MA, Suazo M, González M, Opazo C, Bush AI, Inestrosa NC. The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1701-3. PMID 15345692 DOI: 10.1096/fj.03-1349fje  1
2004 Ciccotosto GD, Tew D, Curtain CC, Smith D, Carrington D, Masters CL, Bush AI, Cherny RA, Cappai R, Barnham KJ. Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution. The Journal of Biological Chemistry. 279: 42528-34. PMID 15292164 DOI: 10.1074/jbc.M406465200  1
2004 Barnham KJ, Haeffner F, Ciccotosto GD, Curtain CC, Tew D, Mavros C, Beyreuther K, Carrington D, Masters CL, Cherny RA, Cappai R, Bush AI. Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1427-9. PMID 15231727 DOI: 10.1096/fj.04-1890fje  1
2004 Bush AI, Strozyk D. Serum copper: a biomarker for Alzheimer disease? Archives of Neurology. 61: 631-2. PMID 15148135 DOI: 10.1001/archneur.61.5.631  0.36
2004 Yao S, Cherny RA, Bush AI, Masters CL, Barnham KJ. Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR. Journal of Peptide Science : An Official Publication of the European Peptide Society. 10: 210-7. PMID 15119593 DOI: 10.1002/psc.539  1
2004 Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Annals of the New York Academy of Sciences. 1012: 153-63. PMID 15105262 DOI: 10.1196/annals.1306.012  1
2004 Friedlich AL, Lee JY, van Groen T, Cherny RA, Volitakis I, Cole TB, Palmiter RD, Koh JY, Bush AI. Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3453-9. PMID 15056725 DOI: 10.1523/JNEUROSCI.0297-04.2004  1
2004 Barnham KJ, Masters CL, Bush AI. Neurodegenerative diseases and oxidative stress. Nature Reviews. Drug Discovery. 3: 205-14. PMID 15031734 DOI: 10.1038/nrd1330  1
2004 White AR, Barnham KJ, Huang X, Voltakis I, Beyreuther K, Masters CL, Cherny RA, Bush AI, Cappai R. Iron inhibits neurotoxicity induced by trace copper and biological reductants. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 269-80. PMID 14758525 DOI: 10.1007/s00775-004-0521-8  1
2004 Nagano S, Huang X, Moir RD, Payton SM, Tanzi RE, Bush AI. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. The Journal of Biological Chemistry. 279: 14673-8. PMID 14724276 DOI: 10.1074/jbc.M313003200  1
2004 Atwood CS, Perry G, Zeng H, Kato Y, Jones WD, Ling KQ, Huang X, Moir RD, Wang D, Sayre LM, Smith MA, Chen SG, Bush AI. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta. Biochemistry. 43: 560-8. PMID 14717612 DOI: 10.1021/bi0358824  1
2004 Lee JY, Kim JH, Hong SH, Lee JY, Cherny RA, Bush AI, Palmiter RD, Koh JY. Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain. The Journal of Biological Chemistry. 279: 8602-7. PMID 14681234 DOI: 10.1074/jbc.M309730200  1
2003 Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, Kiers L, Cherny R, Li QX, Tammer A, Carrington D, Mavros C, Volitakis I, Xilinas M, Ames D, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Archives of Neurology. 60: 1685-91. PMID 14676042 DOI: 10.1001/archneur.60.12.1685  1
2003 Bush AI, Masters CL, Tanzi RE. Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection. Proceedings of the National Academy of Sciences of the United States of America. 100: 11193-4. PMID 14506299 DOI: 10.1073/pnas.2135061100  1
2003 Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, ... ... Bush AI, et al. Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation. The Journal of Biological Chemistry. 278: 42959-65. PMID 12925530 DOI: 10.1074/jbc.M305494200  1
2003 Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, Mavros C, Coccia JA, Faget KY, Fitch KA, Masters CL, Tanzi RE, Chylack LT, Bush AI. Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet. 361: 1258-65. PMID 12699953 DOI: 10.1016/S0140-6736(03)12981-9  1
2003 Kaur D, Yantiri F, Rajagopalan S, Kumar J, Mo JQ, Boonplueang R, Viswanath V, Jacobs R, Yang L, Beal MF, DiMonte D, Volitaskis I, Ellerby L, Cherny RA, Bush AI, et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron. 37: 899-909. PMID 12670420 DOI: 10.1016/S0896-6273(03)00126-0  1
2003 Curtain CC, Ali FE, Smith DG, Bush AI, Masters CL, Barnham KJ. Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid. The Journal of Biological Chemistry. 278: 2977-82. PMID 12435742 DOI: 10.1074/jbc.M205455200  1
2002 Maynard CJ, Cappai R, Volitakis I, Cherny RA, White AR, Beyreuther K, Masters CL, Bush AI, Li QX. Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron. The Journal of Biological Chemistry. 277: 44670-6. PMID 12215434 DOI: 10.1074/jbc.M204379200  1
2002 Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, et al. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. Journal of Molecular Neuroscience : Mn. 19: 77-82. PMID 12212798 DOI: 10.1007/s12031-002-0014-6  1
2002 Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, et al. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. The Journal of Biological Chemistry. 277: 45518-28. PMID 12198135 DOI: 10.1074/jbc.M207435200  1
2002 Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). The Journal of Biological Chemistry. 277: 40302-8. PMID 12192006 DOI: 10.1074/jbc.M206428200  1
2002 Bush AI, Tanzi RE. The galvanization of beta-amyloid in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 7317-9. PMID 12032279 DOI: 10.1073/pnas.122249699  1
2001 Frederickson CJ, Bush AI. Synaptically released zinc: physiological functions and pathological effects. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 14: 353-66. PMID 11831465 DOI: 10.1023/A:1012934207456  1
2001 Jobling MF, Huang X, Stewart LR, Barnham KJ, Curtain C, Volitakis I, Perugini M, White AR, Cherny RA, Masters CL, Barrow CJ, Collins SJ, Bush AI, Cappai R. Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126. Biochemistry. 40: 8073-84. PMID 11434776  1
2001 Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, ... ... Bush AI, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 30: 665-76. PMID 11430801 DOI: 10.1016/S0896-6273(01)00317-8  1
2001 Bush AI, Goldstein LE. Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts. Novartis Foundation Symposium. 235: 26-38; discussion 38. PMID 11280030  0.52
2001 Curtain CC, Ali F, Volitakis I, Cherny RA, Norton RS, Beyreuther K, Barrow CJ, Masters CL, Bush AI, Barnham KJ. Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. The Journal of Biological Chemistry. 276: 20466-73. PMID 11274207 DOI: 10.1074/jbc.M100175200  1
2001 White AR, Huang X, Jobling MF, Barrow CJ, Beyreuther K, Masters CL, Bush AI, Cappai R. Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. Journal of Neurochemistry. 76: 1509-20. PMID 11238735 DOI: 10.1046/j.1471-4159.2001.00178.x  1
2001 Rottkamp CA, Raina AK, Zhu X, Gaier E, Bush AI, Atwood CS, Chevion M, Perry G, Smith MA. Redox-active iron mediates amyloid-beta toxicity. Free Radical Biology & Medicine. 30: 447-50. PMID 11182300 DOI: 10.1016/S0891-5849(00)00494-9  1
2000 Bush AI, Atwood CS, Goldstein LE, Huang X, Rogers J. Could Abeta and AbetaPP be Antioxidants? Journal of Alzheimer's Disease : Jad. 2: 83-84. PMID 12214093  0.76
2000 Cuajungco MP, Fagét KY, Huang X, Tanzi RE, Bush AI. Metal chelation as a potential therapy for Alzheimer's disease. Annals of the New York Academy of Sciences. 920: 292-304. PMID 11193167  1
2000 Lynch T, Cherny RA, Bush AI. Oxidative processes in Alzheimer's disease: the role of abeta-metal interactions. Experimental Gerontology. 35: 445-51. PMID 10959032  0.68
2000 Andreassen OA, Dedeoglu A, Klivenyi P, Beal MF, Bush AI. N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. Neuroreport. 11: 2491-3. PMID 10943709  1
2000 Cherny RA, Barnham KJ, Lynch T, Volitakis I, Li QX, McLean CA, Multhaup G, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. Journal of Structural Biology. 130: 209-16. PMID 10940226 DOI: 10.1006/jsbi.2000.4285  1
2000 Atwood CS, Scarpa RC, Huang X, Moir RD, Jones WD, Fairlie DP, Tanzi RE, Bush AI. Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. Journal of Neurochemistry. 75: 1219-33. PMID 10936205 DOI: 10.1046/j.1471-4159.2000.0751219.x  1
2000 Atwood CS, Huang X, Khatri A, Scarpa RC, Kim YS, Moir RD, Tanzi RE, Roher AE, Bush AI. Copper catalyzed oxidation of Alzheimer Abeta. Cellular and Molecular Biology (Noisy-Le-Grand, France). 46: 777-83. PMID 10875439  1
2000 Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M, Lim JT, Faget KY, Muffat JA, Scarpa RC, Chylack LT, Bowden EF, Tanzi RE, Bush AI. 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry. 39: 7266-75. PMID 10852726 DOI: 10.1021/bi992997s  1
2000 Huang X, Cuajungco MP, Atwood CS, Moir RD, Tanzi RE, Bush AI. Alzheimer's disease, beta-amyloid protein and zinc. The Journal of Nutrition. 130: 1488S-92S. PMID 10801964  1
2000 Cuajungco MP, Goldstein LE, Nunomura A, Smith MA, Lim JT, Atwood CS, Huang X, Farrag YW, Perry G, Bush AI. Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc. The Journal of Biological Chemistry. 275: 19439-42. PMID 10801774 DOI: 10.1074/jbc.C000165200  1
1999 Cuajungco MP, Lees GJ, Kydd RR, Tanzi RE, Bush AI. Zinc and Alzheimer's Disease: An Update. Nutritional Neuroscience. 2: 191-208. PMID 27415572 DOI: 10.1080/1028415X.1999.11747277  1
1999 Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, ... ... Bush AI, et al. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. The Journal of Biological Chemistry. 274: 37111-6. PMID 10601271 DOI: 10.1074/jbc.274.52.37111  1
1999 McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Annals of Neurology. 46: 860-6. PMID 10589538 DOI: 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M  1
1999 White AR, Multhaup G, Maher F, Bellingham S, Camakaris J, Zheng H, Bush AI, Beyreuther K, Masters CL, Cappai R. The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9170-9. PMID 10531420  1
1999 White AR, Reyes R, Mercer JF, Camakaris J, Zheng H, Bush AI, Multhaup G, Beyreuther K, Masters CL, Cappai R. Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice. Brain Research. 842: 439-44. PMID 10526140  1
1999 Cherny RA, Legg JT, McLean CA, Fairlie DP, Huang X, Atwood CS, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. The Journal of Biological Chemistry. 274: 23223-8. PMID 10438495 DOI: 10.1074/jbc.274.33.23223  1
1999 Moir RD, Atwood CS, Huang X, Tanzi RE, Bush AI. Mounting evidence for the involvement of zinc and copper in Alzheimer's disease. European Journal of Clinical Investigation. 29: 569-70. PMID 10411660 DOI: 10.1046/j.1365-2362.1999.00472.x  1
1999 Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 38: 7609-16. PMID 10386999 DOI: 10.1021/bi990438f  1
1999 Li QX, Maynard C, Cappai R, McLean CA, Cherny RA, Lynch T, Culvenor JG, Trevaskis J, Tanner JE, Bailey KA, Czech C, Bush AI, Beyreuther K, Masters CL. Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice. Journal of Neurochemistry. 72: 2479-87. PMID 10349858 DOI: 10.1046/j.1471-4159.1999.0722479.x  1
1999 White AR, Bush AI, Beyreuther K, Masters CL, Cappai R. Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione. Journal of Neurochemistry. 72: 2092-8. PMID 10217289  1
1999 Moir RD, Atwood CS, Romano DM, Laurans MH, Huang X, Bush AI, Smith JD, Tanzi RE. Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations. Biochemistry. 38: 4595-603. PMID 10194381 DOI: 10.1021/bi982437d  1
1999 Atwood CS, Huang X, Moir RD, Tanzi RE, Bush AI. Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease. Metal Ions in Biological Systems. 36: 309-64. PMID 10093929  1
1998 Bush AI, Tanzi RE. Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery? Archives of Neurology. 55: 1179-80. PMID 9740110 DOI: 10.1001/archneur.55.9.1179  1
1998 Atwood CS, Moir RD, Huang X, Scarpa RC, Bacarra NM, Romano DM, Hartshorn MA, Tanzi RE, Bush AI. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. The Journal of Biological Chemistry. 273: 12817-26. PMID 9582309 DOI: 10.1074/jbc.273.21.12817  1
1998 Moir RD, Lynch T, Bush AI, Whyte S, Henry A, Portbury S, Multhaup G, Small DH, Tanzi RE, Beyreuther K, Masters CL. Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain. The Journal of Biological Chemistry. 273: 5013-9. PMID 9478949 DOI: 10.1074/jbc.273.9.5013  1
1997 Huang X, Atwood CS, Moir RD, Hartshorn MA, Vonsattel JP, Tanzi RE, Bush AI. Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors. The Journal of Biological Chemistry. 272: 26464-70. PMID 9334223 DOI: 10.1074/jbc.272.42.26464  1
1997 Aschner M, Cherian MG, Klaassen CD, Palmiter RD, Erickson JC, Bush AI. Metallothioneins in brain--the role in physiology and pathology. Toxicology and Applied Pharmacology. 142: 229-42. PMID 9070344 DOI: 10.1006/taap.1996.8054  1
1995 Bush AI, Moir RD, Rosenkranz KM, Tanzi RE. Response. Science (New York, N.Y.). 268: 1921-3. PMID 17797535 DOI: 10.1126/science.268.5219.1921  1
1995 Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 82: 331-40. PMID 7543026 DOI: 10.1016/0092-8674(95)90320-8  1
1994 Bush AI, Pettingell WH, Paradis MD, Tanzi RE. Modulation of A beta adhesiveness and secretase site cleavage by zinc. The Journal of Biological Chemistry. 269: 12152-8. PMID 8163520  1
1994 Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel JP, Gusella JF, Beyreuther K, Masters CL, Tanzi RE. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (New York, N.Y.). 265: 1464-7. PMID 8073293  1
1994 Li QX, Berndt MC, Bush AI, Rumble B, Mackenzie I, Friedhuber A, Beyreuther K, Masters CL. Membrane-associated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelet and brain: surface expression on the activated human platelet. Blood. 84: 133-42. PMID 8018913  1
1994 Multhaup G, Bush AI, Pollwein P, Masters CL. Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP). Febs Letters. 355: 151-4. PMID 7982489  1
1994 Bush AI, Pettingell WH, de Paradis M, Tanzi RE, Wasco W. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. The Journal of Biological Chemistry. 269: 26618-21. PMID 7929392  1
1994 Tanzi RE, Bush AI, Wasco W. Genetic studies of Alzheimer's disease: lessons learned and future imperatives. Neurobiology of Aging. 15: S145-8. PMID 7700440 DOI: 10.1016/0197-4580(94)90193-7  1
1993 Bush AI, Multhaup G, Moir RD, Williamson TG, Small DH, Rumble B, Pollwein P, Beyreuther K, Masters CL. A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. The Journal of Biological Chemistry. 268: 16109-12. PMID 8344894  1
1993 Bush AI, Beyreuther K, Masters CL. The beta A4 amyloid protein precursor in human circulation. Annals of the New York Academy of Sciences. 695: 175-82. PMID 8239279  1
1992 Bush AI, Whyte S, Thomas LD, Williamson TG, Van Tiggelen CJ, Currie J, Small DH, Moir RD, Li QX, Rumble B. An abnormality of plasma amyloid protein precursor in Alzheimer's disease. Annals of Neurology. 32: 57-65. PMID 1642473 DOI: 10.1002/ana.410320110  1
1992 Moir RD, Martins RN, Bush AI, Small DH, Milward EA, Rumble BA, Multhaup G, Beyreuther K, Masters CL. Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization. Journal of Neurochemistry. 59: 1490-8. PMID 1402900  1
1992 Bush AI, Beyreuther K, Masters CL. Beta A4 amyloid protein and its precursor in Alzheimer's disease. Pharmacology & Therapeutics. 56: 97-117. PMID 1297146  1
1991 Beyreuther K, Bush AI, Dyrks T, Hilbich C, König G, Mönning U, Multhaup G, Prior R, Rumble B, Schubert W. Mechanisms of amyloid deposition in Alzheimer's disease. Annals of the New York Academy of Sciences. 640: 129-39. PMID 1776729  1
1991 Small DH, Moir RD, Fuller SJ, Michaelson S, Bush AI, Li QX, Milward E, Hilbich C, Weidemann A, Beyreuther K. A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease. Biochemistry. 30: 10795-9. PMID 1718425  1
1990 Bush AI, Martins RN, Rumble B, Moir R, Fuller S, Milward E, Currie J, Ames D, Weidemann A, Fischer P. The amyloid precursor protein of Alzheimer's disease is released by human platelets. The Journal of Biological Chemistry. 265: 15977-83. PMID 2118534  0.6
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