Keith A. Sharkey - Publications

Affiliations: 
Hotchkiss Brain Institute University of Calgary, Calgary, Alberta, Canada 
Area:
Enteric nervous system, endocannabinoids, intestinal inflammation

277 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Cluny NL, Nyuyki KD, Almishri W, Griffin L, Lee BH, Hirota SA, Pittman QJ, Swain MG, Sharkey KA. Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior. Journal of Neuroinflammation. 19: 73. PMID 35379260 DOI: 10.1186/s12974-022-02431-z  0.774
2022 Vicentini FA, Szamosi JC, Rossi L, Griffin L, Nieves K, Bihan D, Lewis IA, Pittman QJ, Swain MG, Surette MG, Hirota SA, Sharkey KA. Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation. Brain, Behavior, and Immunity. 102: 266-278. PMID 35259427 DOI: 10.1016/j.bbi.2022.03.001  0.635
2021 Vecchiarelli HA, Aukema RJ, Hume C, Chiang V, Morena M, Keenan CM, Nastase AS, Lee FS, Pittman QJ, Sharkey KA, Hill MN. Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice. Frontiers in Cellular Neuroscience. 15: 764706. PMID 34916909 DOI: 10.3389/fncel.2021.764706  0.618
2021 Vicentini FA, Mathews AJ, Pittman QJ, Swain MG, Sharkey KA, Hirota SA. Behavioural adaptations after antibiotic treatment in male mice are reversed by activation of the aryl hydrocarbon receptor. Brain, Behavior, and Immunity. PMID 34461234 DOI: 10.1016/j.bbi.2021.08.228  0.623
2021 Acharjee S, Gordon PMK, Lee BH, Read J, Workentine ML, Sharkey KA, Pittman QJ. Characterization of microglial transcriptomes in the brain and spinal cord of mice in early and late experimental autoimmune encephalomyelitis using a RiboTag strategy. Scientific Reports. 11: 14319. PMID 34253764 DOI: 10.1038/s41598-021-93590-1  0.575
2021 Vecchiarelli HA, Morena M, Keenan CM, Chiang V, Tan K, Qiao M, Leitl K, Santori A, Pittman QJ, Sharkey KA, Hill MN. Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 33452437 DOI: 10.1038/s41386-020-00939-7  0.628
2020 Lopes F, Vicentini FA, Cluny NL, Mathews AJ, Lee BH, Almishri WA, Griffin L, Gonçalves W, Pinho V, McKay DM, Hirota SA, Swain MG, Pittman QJ, Sharkey KA. Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis. Brain, Behavior, and Immunity. PMID 32592863 DOI: 10.1016/J.Bbi.2020.06.023  0.77
2020 van Tilburg Bernardes E, Pettersen VK, Gutierrez MW, Laforest-Lapointe I, Jendzjowsky NG, Cavin JB, Vicentini FA, Keenan CM, Ramay HR, Samara J, MacNaughton WK, Wilson RJA, Kelly MM, McCoy KD, Sharkey KA, et al. Intestinal fungi are causally implicated in microbiome assembly and immune development in mice. Nature Communications. 11: 2577. PMID 32444671 DOI: 10.1038/S41467-020-16431-1  0.326
2020 Esquerre N, Basso L, Defaye M, Vicentini FA, Cluny N, Bihan D, Hirota SA, Schick A, Jijon HB, Lewis IA, Geuking MB, Sharkey KA, Altier C, Nasser Y. COLITIS-INDUCED MICROBIAL PERTURBATION PROMOTES POST-INFLAMMATORY VISCERAL HYPERSENSITIVITY. Cellular and Molecular Gastroenterology and Hepatology. PMID 32289500 DOI: 10.1016/J.Jcmgh.2020.04.003  0.795
2020 Matisz CE, Vicentini FA, Hirota SA, Sharkey KA, Gruber AJ. Behavioral adaptations in a relapsing mouse model of colitis. Physiology & Behavior. 216: 112802. PMID 31931038 DOI: 10.1016/J.Physbeh.2020.112802  0.315
2020 Vicentini F, Griffin L, Keenan C, Cavin J, Nieves K, Hirota SA, Sharkey KA. A37 ENTERIC MICROBIOTA CONTRIBUTE TO BEHAVIORAL ALTERATIONS OBSERVED IN MICE WITH COLITIS Journal of the Canadian Association of Gastroenterology. 3: 44-45. DOI: 10.1096/Fasebj.2020.34.S1.05739  0.353
2019 Cavin JB, Cuddihey H, MacNaughton WK, Sharkey KA. Acute regulation of intestinal ion transport and permeability in response to luminal nutrients: the role of the enteric nervous system. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31709828 DOI: 10.1152/Ajpgi.00186.2019  0.319
2019 Wang SJ, Sharkey KA, McKay DM, Wang A, Wallace L. A162 EXPULSION OF THE TAPEWORM HYMENOLEPIS DIMINUTA FROM MICE OCCURS INDEPENDENT OF SEROTONERIC SIGNALLING Journal of the Canadian Association of Gastroenterology. 2: 321-322. DOI: 10.1093/JCAG/GWZ006.161  0.362
2019 Rajeev S, Wang SJ, Wallace L, Sharkey KA, McKay DM. A161 INFECTION WITH THE TAPEWORM HYMENOLEPIS DIMINUTA EVOKES A MASSIVE, BUT DELAYED INCREASE IN TUFT CELLS IN THE MURINE INTESTINE Journal of the Canadian Association of Gastroenterology. 2: 320-320. DOI: 10.1093/JCAG/GWZ006.160  0.375
2019 Esquerre N, Basso L, Vicentini F, Cluny NL, Lewis I, Sharkey KA, Altier C, Nasser Y. A52 ANTIBIOTICS WORSEN VISCERAL BUT NOT SOMATIC HYPERALGESIA IN A MOUSE MODEL OF POST-INFLAMMATORY EXPERIMENTAL COLITIS. Journal of the Canadian Association of Gastroenterology. 2: 103-104. DOI: 10.1093/jcag/gwz006.051  0.776
2019 Esquerre N, Basso L, Vicentini F, Cluny N, Lewis I, Sharkey KA, Altier C, Nasser Y. Sa1907 – Antibiotics Worsen Visceral But Not Somatic Hyperalgesia in a Mouse Model of Post-Inflammatory Experimental Colitis Gastroenterology. 156: S-448. DOI: 10.1016/S0016-5085(19)37973-9  0.782
2018 Acharjee S, Verbeek M, Daniel Gomez C, Bisht K, Lee B, Benoit L, Sharkey KA, Benediktsson A, Tremblay ME, Pittman QJ. Reduced microglial activity and enhanced glutamate transmission in the basolateral amygdala in early CNS autoimmunity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30185466 DOI: 10.1523/Jneurosci.0398-18.2018  0.664
2018 Wang SJ, Sharkey KA, McKay DM. Modulation of the immune response by helminths: a role for serotonin? Bioscience Reports. 38. PMID 30177522 DOI: 10.1042/Bsr20180027  0.488
2018 Matisz CE, Geuking MB, Lopes F, Petri B, Wang A, Sharkey KA, McKay DM. Helminth Antigen-Conditioned Dendritic Cells Generate Anti-Inflammatory CD4 T Cells Independent of Antigen Presentation via MHC II. The American Journal of Pathology. PMID 30121255 DOI: 10.1016/J.Ajpath.2018.07.008  0.472
2018 Sharkey KA, Beck PL, McKay DM. Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium. Nature Reviews. Gastroenterology & Hepatology. PMID 30069036 DOI: 10.1038/S41575-018-0051-4  0.503
2018 Lavoie B, Roberts JA, Haag MM, Spohn SN, Margolis KG, Sharkey KA, Lian JB, Mawe GM. GUT-DERIVED Serotonin CONTRIBUTES to Bone Deficits in Colitis. Pharmacological Research. PMID 30030171 DOI: 10.1016/J.Phrs.2018.07.018  0.55
2018 Camara-Lemarroy CR, Metz L, Meddings JB, Sharkey KA, Wee Yong V. The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics. Brain : a Journal of Neurology. PMID 29860380 DOI: 10.1093/Brain/Awy131  0.332
2018 Nyuyki KD, Cluny NL, Swain MG, Sharkey KA, Pittman QJ. Altered Brain Excitability and Increased Anxiety in Mice With Experimental Colitis: Consideration of Hyperalgesia and Sex Differences. Frontiers in Behavioral Neuroscience. 12: 58. PMID 29670513 DOI: 10.3389/Fnbeh.2018.00058  0.789
2018 MacEachern SJ, Keenan CM, Papakonstantinou E, Sharkey KA, Patel BA. Alterations in melatonin and serotonin signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis. British Journal of Pharmacology. PMID 29447434 DOI: 10.1111/Bph.14163  0.625
2018 Vicentini F, Pittman Q, Swain M, Hirota SA, Sharkey KA. A286 MICROBIOTA DEPLETION IN ADULTHOOD ALTERS MOUSE BEHAVIOR WITH POTENTIAL INVOLVEMENT OF MICROBIAL-METABOLITE SENSOR IN THE BRAIN Journal of the Canadian Association of Gastroenterology. 1: 412-412. DOI: 10.1093/JCAG/GWY009.286  0.571
2018 Vicentini F, Cluny N, Griffin L, Pittman Q, Swain M, Hirota SA, Sharkey KA. A134 ANALYSIS OF POTENTIAL MICROBIAL-METABOLITE SENSORS IN THE BRAIN DURING EXPERIMENTAL COLITIS Journal of the Canadian Association of Gastroenterology. 1: 233-234. DOI: 10.1093/jcag/gwy008.135  0.759
2018 Esquerre N, Basso L, Vicentini F, Cluny N, Sharkey KA, Altier C, Nasser Y. Su1962 - Antibiotics Worsen Visceral but not Somatic Hyperalgesia in a Mouse Model of Post-Inflammatory IBD Gastroenterology. 154: S-647-S-648. DOI: 10.1016/S0016-5085(18)32308-4  0.785
2017 Bashashati M, Moossavi S, Cremon C, Barbaro MR, Moraveji S, Talmon G, Rezaei N, Hughes PA, Bian ZX, Choi CH, Lee OY, Coëffier M, Chang L, Ohman L, Schmulson MJ, ... ... Sharkey KA, et al. Colonic immune cells in irritable bowel syndrome: A systematic review and meta-analysis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. PMID 28851005 DOI: 10.1111/Nmo.13192  0.554
2017 Rademakers G, Vaes N, Schonkeren S, Koch A, Sharkey KA, Melotte V. The role of enteric neurons in the development and progression of colorectal cancer. Biochimica Et Biophysica Acta. PMID 28847715 DOI: 10.1016/J.Bbcan.2017.08.003  0.336
2017 Matisz CE, Faz-López B, Thomson E, Al Rajabi A, Lopes F, Terrazas LI, Wang A, Sharkey KA, McKay DM. Suppression of colitis by adoptive transfer of helminth antigen-treated dendritic cells requires interleukin-4 receptor-α signaling. Scientific Reports. 7: 40631. PMID 28094779 DOI: 10.1038/Srep40631  0.45
2016 Spohn SN, Bianco F, Scott RB, Keenan CM, Linton AA, O'Neill CH, Bonora E, Dicay M, Lavoie B, Wilcox RL, MacNaughton WK, De Giorgio R, Sharkey KA, Mawe GM. Protective Actions of Epithelial 5-hydroxytryptamine 4 Receptors in Normal and Inflamed Colon. Gastroenterology. PMID 27480173 DOI: 10.1053/J.Gastro.2016.07.032  0.617
2016 Krohn RM, Parsons SA, Fichna J, Patel KD, Yates RM, Sharkey KA, Storr MA. Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment. Journal of Inflammation (London, England). 13: 21. PMID 27418880 DOI: 10.1186/S12950-016-0129-0  0.511
2016 Mawe GM, Sharkey KA. The Intrinsic Reflex Circuitry of the Inflamed Colon. Advances in Experimental Medicine and Biology. 891: 153-157. PMID 27379643 DOI: 10.1007/978-3-319-27592-5_15  0.592
2016 Sharkey KA, Wiley JW. Getting into the weed: the role of the endocannabinoid system in the brain-gut axis. Gastroenterology. PMID 27133395 DOI: 10.1053/J.Gastro.2016.04.015  0.342
2016 Miller KA, Keenan CM, Martin GR, Jirik FR, Sharkey KA, Wieser ME. The expression levels of cellular prion protein affect copper isotopic shifts in the organs of mice Journal of Analytical Atomic Spectrometry. 31: 2015-2022. DOI: 10.1039/C6Ja00195E  0.489
2015 Trautmann SM, Sharkey KA. The Endocannabinoid System and Its Role in Regulating the Intrinsic Neural Circuitry of the Gastrointestinal Tract. International Review of Neurobiology. 125: 85-126. PMID 26638765 DOI: 10.1016/Bs.Irn.2015.10.002  0.387
2015 Cluny NL, Keenan CM, Reimer RA, Le Foll B, Sharkey KA. Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ9-Tetrahydrocannabinol. Plos One. 10: e0144270. PMID 26633823 DOI: 10.1371/Journal.Pone.0144270  0.744
2015 Sticht MA, Limebeer CL, Rafla BR, Abdullah RA, Poklis JL, Ho W, Niphakis MJ, Cravatt BF, Sharkey KA, Lichtman AH, Parker LA. Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex. Neuropharmacology. PMID 26541329 DOI: 10.1016/J.Neuropharm.2015.10.039  0.362
2015 Matisz CE, Leung G, Reyes JL, Wang A, Sharkey KA, McKay DM. Adoptive transfer of helminth antigen-pulsed dendritic cells protects against the development of experimental colitis in mice. European Journal of Immunology. PMID 26332354 DOI: 10.1002/Eji.201545579  0.464
2015 Fichna J, Poole DP, Veldhuis N, MacEachern SJ, Saur D, Zakrzewski PK, Cygankiewicz AI, Mokrowiecka A, Małecka-Panas E, Krajewska WM, Liedtke W, Steinhoff MS, Timmermans JP, Bunnett NW, Sharkey KA, et al. Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. Journal of Molecular Medicine (Berlin, Germany). PMID 26330151 DOI: 10.1007/s00109-015-1336-5  0.71
2015 Lopes F, Graepel R, Reyes JL, Wang A, Petri B, McDougall JJ, Sharkey KA, McKay DM. Involvement of mast cells in α7 nicotinic receptor agonist-exacerbation of complete Freund's adjuvant-induced mono-arthritis in mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26314943 DOI: 10.1002/Art.39411  0.492
2015 MacEachern SJ, Patel BA, Keenan CM, Dicay M, Chapman K, McCafferty DM, Savidge TC, Beck PL, MacNaughton WK, Sharkey KA. Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis. Gastroenterology. 149: 445-455.e3. PMID 25865048 DOI: 10.1053/J.Gastro.2015.04.007  0.615
2015 Cluny NL, Eller LK, Keenan CM, Reimer RA, Sharkey KA. Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet-induced obese rats. Obesity (Silver Spring, Md.). 23: 769-78. PMID 25820256 DOI: 10.1002/Oby.21017  0.725
2015 Riazi K, Galic MA, Kentner AC, Reid AY, Sharkey KA, Pittman QJ. Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4942-52. PMID 25810524 DOI: 10.1523/Jneurosci.4485-14.2015  0.653
2015 Bashashati M, Nasser Y, Keenan CM, Ho W, Piscitelli F, Nalli M, Mackie K, Storr MA, Di Marzo V, Sharkey KA. Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation. British Journal of Pharmacology. 172: 3099-111. PMID 25684407 DOI: 10.1111/Bph.13114  0.759
2015 Bashashati M, Habibi HR, Keshavarzian A, Schmulson M, Sharkey KA. Intestinal microbiota: a regulator of intestinal inflammation and cardiac ischemia? Current Drug Targets. 16: 199-208. PMID 25601328 DOI: 10.2174/1389450116666150120104012  0.54
2015 Martin GR, Sharkey KA, Jirik FR. Orally administered indomethacin acutely reduces cellular prion protein in the small intestine and modestly increases survival of mice exposed to infectious prions. Scandinavian Journal of Gastroenterology. 50: 542-9. PMID 25599123 DOI: 10.3109/00365521.2014.1003400  0.482
2015 Keenan CM, Storr MA, Thakur GA, Wood JT, Wager-Miller J, Straiker A, Eno MR, Nikas SP, Bashashati M, Hu H, Mackie K, Makriyannis A, Sharkey KA. AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner. British Journal of Pharmacology. 172: 2406-18. PMID 25572435 DOI: 10.1111/Bph.13069  0.69
2015 Li W, Baraboi ED, Cluny NL, Roy MC, Samson P, Biertho L, Sharkey KA, Richard D. Malabsorption plays a major role in the effects of the biliopancreatic diversion with duodenal switch on energy metabolism in rats. Surgery For Obesity and Related Diseases : Official Journal of the American Society For Bariatric Surgery. 11: 356-66. PMID 25553888 DOI: 10.1016/J.Soard.2014.07.020  0.712
2015 Bashashati M, Rezaei N, Quigley EM, Schmulson MJ, Sharkey KA. Mo2042 TNFα in Irritable Bowel Syndrome (IBS): From Gene Polymorphisms to Circulating Levels Gastroenterology. 148: S-777. DOI: 10.1016/S0016-5085(15)32651-2  0.532
2015 Bashashati M, Keenan CM, Burkhardt W, Hermanson DJ, Kingsley PJ, Patel S, Marnett L, Sharkey KA. 386 Endocannabinoid-Mediated Effects of Substrate-Selective COX-2 Inhibitors on Gastrointestinal Motility in the Mouse Gastroenterology. 148: S-80. DOI: 10.1016/S0016-5085(15)30280-8  0.561
2014 Fichna J, Bawa M, Thakur GA, Tichkule R, Makriyannis A, McCafferty DM, Sharkey KA, Storr M. Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors. Plos One. 9: e109115. PMID 25275313 DOI: 10.1371/Journal.Pone.0109115  0.576
2014 Sharkey KA, Mawe GM. Neurohormonal signalling in the gastrointestinal tract: new frontiers. The Journal of Physiology. 592: 2923-5. PMID 24928959 DOI: 10.1113/Jphysiol.2014.275487  0.514
2014 Bashashati M, Rezaei N, Shafieyoun A, McKernan DP, Chang L, Öhman L, Quigley EM, Schmulson M, Sharkey KA, Simrén M. Cytokine imbalance in irritable bowel syndrome: a systematic review and meta-analysis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 26: 1036-48. PMID 24796536 DOI: 10.1111/Nmo.12358  0.556
2014 Sharkey KA, Savidge TC. Reprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Autonomic Neuroscience : Basic & Clinical. 182: 70-82. PMID 24674836 DOI: 10.1016/J.Autneu.2014.03.004  0.305
2014 Ahmed AS, Dai L, Ho W, Ferguson AV, Sharkey KA. The subfornical organ: a novel site of action of cholecystokinin. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 306: R363-73. PMID 24430886 DOI: 10.1152/Ajpregu.00462.2013  0.594
2014 Sharkey KA, Savidge TC. Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Autonomic Neuroscience : Basic & Clinical. 181: 94-106. PMID 24412639 DOI: 10.1016/J.Autneu.2013.12.006  0.305
2014 Sharkey KA, Darmani NA, Parker LA. Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. European Journal of Pharmacology. 722: 134-46. PMID 24184696 DOI: 10.1016/J.Ejphar.2013.09.068  0.319
2014 Bashashati M, Ho W, Mackie K, Hollenberg MD, Sharkey KA. Sa2055 Alpha/Beta Hydrolase Domain 6 (ABHD6), A Novel Endocannabinoid Hydrolytic Enzyme, Regulates Contractility in the Mouse Intestine Gastroenterology. 146: S-365. DOI: 10.1016/S0016-5085(14)61322-6  0.631
2014 Spohn SN, Lavoie B, MacEachern S, Roberts JA, Wilcox R, Sharkey KA, Mawe GM. 415 Intraluminal 5-HT4 Agonist Treatment Improves DSS Colitis in Mice Gastroenterology. 146: S-89. DOI: 10.1016/S0016-5085(14)60323-1  0.695
2014 Lavoie B, Roberts JA, Sharkey KA, Lian JB, Mawe GM. 195 Gut-Derived Serotonin Decreases Bone Density in the DSS Model of Colitis in Mice Gastroenterology. 146: S-51. DOI: 10.1016/S0016-5085(14)60178-5  0.529
2013 Cluny NL, Baraboi ED, Mackie K, Burdyga G, Richard D, Dockray GJ, Sharkey KA. High fat diet and body weight have different effects on cannabinoid CB(1) receptor expression in rat nodose ganglia. Autonomic Neuroscience : Basic & Clinical. 179: 122-30. PMID 24145047 DOI: 10.1016/J.Autneu.2013.09.015  0.795
2013 Duncan M, Galic MA, Wang A, Chambers AP, McCafferty DM, McKay DM, Sharkey KA, Pittman QJ. Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 305: R224-31. PMID 23739343 DOI: 10.1152/Ajpregu.00104.2013  0.794
2013 Roberts JA, Durnin L, Sharkey KA, Mutafova-Yambolieva VN, Mawe GM. Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon. The Journal of Physiology. 591: 3725-37. PMID 23732648 DOI: 10.1113/Jphysiol.2013.254136  0.566
2013 Li K, Fichna J, Schicho R, Saur D, Bashashati M, Mackie K, Li Y, Zimmer A, Göke B, Sharkey KA, Storr M. A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. Neuropharmacology. 71: 255-63. PMID 23603203 DOI: 10.1016/J.Neuropharm.2013.03.029  0.75
2013 Graepel R, Leung G, Wang A, Villemaire M, Jirik FR, Sharkey KA, McDougall JJ, McKay DM. Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta. International Journal For Parasitology. 43: 593-601. PMID 23583716 DOI: 10.1016/J.Ijpara.2013.02.006  0.482
2013 Seyfried F, Li JV, Miras AD, Cluny NL, Lannoo M, Fenske WK, Sharkey KA, Nicholson JK, le Roux CW, Holmes E. Urinary phenotyping indicates weight loss-independent metabolic effects of Roux-en-Y gastric bypass in mice. Journal of Proteome Research. 12: 1245-53. PMID 23336719 DOI: 10.1021/Pr300909V  0.733
2013 Bashashati M, Rezaei N, Shafieyoun A, Samii L, Sharkey KA. Mo2034 Reduced Expression of Colonic Mucosal IL-10 mRNA in Irritable Bowel Syndrome: A Meta-Analysis Gastroenterology. 144: S-723. DOI: 10.1016/S0016-5085(13)62686-4  0.553
2012 Roberts JA, Lukewich MK, Sharkey KA, Furness JB, Mawe GM, Lomax AE. The roles of purinergic signaling during gastrointestinal inflammation. Current Opinion in Pharmacology. 12: 659-66. PMID 23063457 DOI: 10.1016/J.Coph.2012.09.011  0.731
2012 Hu H, Ho W, Mackie K, Pittman QJ, Sharkey KA. Brain CB₁ receptor expression following lipopolysaccharide-induced inflammation. Neuroscience. 227: 211-22. PMID 23041513 DOI: 10.1016/J.Neuroscience.2012.09.067  0.721
2012 Bashashati M, Rezaei N, Bashashati H, Shafieyoun A, Daryani NE, Sharkey KA, Storr M. Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta-analysis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 24: 1102-e566. PMID 22897390 DOI: 10.1111/J.1365-2982.2012.01990.X  0.63
2012 de Heuvel E, Wallace L, Sharkey KA, Sigalet DL. Glucagon-like peptide 2 induces vasoactive intestinal polypeptide expression in enteric neurons via phophatidylinositol 3-kinase-γ signaling. American Journal of Physiology. Endocrinology and Metabolism. 303: E994-1005. PMID 22895780 DOI: 10.1152/Ajpendo.00291.2012  0.35
2012 Gulbransen BD, Sharkey KA. Novel functional roles for enteric glia in the gastrointestinal tract. Nature Reviews. Gastroenterology & Hepatology. 9: 625-32. PMID 22890111 DOI: 10.1038/Nrgastro.2012.138  0.675
2012 Martin GR, Alvarez AL, Bashashati M, Keenan CM, Jirik FR, Sharkey KA. Endogenous cellular prion protein regulates contractility of the mouse ileum. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 24: e412-24. PMID 22762267 DOI: 10.1111/J.1365-2982.2012.01970.X  0.72
2012 Gulbransen BD, Bashashati M, Hirota SA, Gui X, Roberts JA, MacDonald JA, Muruve DA, McKay DM, Beck PL, Mawe GM, Thompson RJ, Sharkey KA. Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis. Nature Medicine. 18: 600-4. PMID 22426419 DOI: 10.1038/Nm.2679  0.804
2012 Cluny NL, Reimer RA, Sharkey KA. Cannabinoid signalling regulates inflammation and energy balance: the importance of the brain-gut axis. Brain, Behavior, and Immunity. 26: 691-8. PMID 22269477 DOI: 10.1016/J.Bbi.2012.01.004  0.744
2012 Hons IM, Storr MA, Mackie K, Lutz B, Pittman QJ, Mawe GM, Sharkey KA. Plasticity of mouse enteric synapses mediated through endocannabinoid and purinergic signaling. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 24: e113-24. PMID 22235973 DOI: 10.1111/J.1365-2982.2011.01860.X  0.786
2012 Hoffman JM, Tyler K, MacEachern SJ, Balemba OB, Johnson AC, Brooks EM, Zhao H, Swain GM, Moses PL, Galligan JJ, Sharkey KA, Greenwood-Van Meerveld B, Mawe GM. Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity. Gastroenterology. 142: 844-854.e4. PMID 22226658 DOI: 10.1053/J.Gastro.2011.12.041  0.697
2012 Bashashati M, Rezaei N, Andrews CN, Chen CQ, Daryani NE, Sharkey KA, Storr MA. Cytokines and irritable bowel syndrome: where do we stand? Cytokine. 57: 201-9. PMID 22178716 DOI: 10.1016/J.Cyto.2011.11.019  0.655
2012 Sharkey KA, Mawe GM. Neurogastroenterology in 2011: Emerging concepts in neurogastroenterology and motility. Nature Reviews. Gastroenterology & Hepatology. 9: 74-6. PMID 22158381 DOI: 10.1038/Nrgastro.2011.247  0.532
2012 Bashashati M, Storr MA, Nikas SP, Wood JT, Godlewski G, Liu J, Ho W, Keenan CM, Zhang H, Alapafuja SO, Cravatt BF, Lutz B, Mackie K, Kunos G, Patel KD, ... ... Sharkey KA, et al. Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice. British Journal of Pharmacology. 165: 1556-71. PMID 21883147 DOI: 10.1111/J.1476-5381.2011.01644.X  0.793
2012 Bashashati M, Rezaei N, Bashashati H, Shafieyoun A, Daryani NE, Sharkey KA, Storr M. Tu1427 Interleukin-10 and TGF-1 Anti-Inflammatory Cytokine Gene Polymorphisms are Involved in the Pathophysiology of Irritable Bowel Syndrome: A Meta-Analysis Gastroenterology. 142: S-830. DOI: 10.1016/S0016-5085(12)63221-1  0.635
2012 Hoffman JM, Tyler KR, MacEachern S, Balemba OB, Johnson AC, Brooks EM, Zhao H, Swain GM, Moses PL, Galligan J, Sharkey KA, Meerveld BG, Mawe GM. Sa1429 Activation of 5-HT4 Receptors in the Colonic Mucosa Elicits 5-HT Release, Goblet Cell Degranulation and Chloride Secretion, While Accelerating Propulsive Motility and Attenuating Visceral Hypersensitivity Gastroenterology. 142: S-303. DOI: 10.1016/S0016-5085(12)61136-6  0.7
2012 Gulbransen BD, Bashashati M, Hirota SA, Roberts JA, Beck PL, MacDonald JA, Muruve D, McKay DM, Mawe GM, Thompson RJ, Sharkey KA. 635 Activating Neuronal P2X7-Pannexin−1 Mediates Inflammation-Induced Enteric Neuron Death Gastroenterology. 142: S-126. DOI: 10.1016/S0016-5085(12)60475-2  0.79
2012 MacEachern S, Patel B, MacNaughton WK, Sharkey KA. 179 Enteric Glia Mediate Nicotinic-Stimulated Epithelial Ion Transport in Mouse Colon Revealed by Acute Glial Metabolic Inhibition Gastroenterology. 142: S-44. DOI: 10.1016/S0016-5085(12)60168-1  0.605
2011 Martin GR, Keenan CM, Sharkey KA, Jirik FR. Endogenous prion protein attenuates experimentally induced colitis. The American Journal of Pathology. 179: 2290-301. PMID 21924230 DOI: 10.1016/J.Ajpath.2011.07.025  0.537
2011 Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M. The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Inflammatory Bowel Diseases. 17: 1651-64. PMID 21744421 DOI: 10.1002/Ibd.21538  0.732
2011 Matisz CE, McDougall JJ, Sharkey KA, McKay DM. Helminth parasites and the modulation of joint inflammation. Journal of Parasitology Research. 2011: 942616. PMID 21584243 DOI: 10.1155/2011/942616  0.456
2011 MacEachern SJ, Patel BA, McKay DM, Sharkey KA. Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus. The Journal of Physiology. 589: 3333-48. PMID 21558161 DOI: 10.1113/Jphysiol.2011.207902  0.698
2011 Hoffman JM, McKnight ND, Sharkey KA, Mawe GM. The relationship between inflammation-induced neuronal excitability and disrupted motor activity in the guinea pig distal colon. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 23: 673-e279. PMID 21426440 DOI: 10.1111/J.1365-2982.2011.01702.X  0.597
2011 Lavoie EG, Gulbransen BD, Martín-Satué M, Aliagas E, Sharkey KA, Sévigny J. Ectonucleotidases in the digestive system: focus on NTPDase3 localization. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G608-20. PMID 21233276 DOI: 10.1152/Ajpgi.00207.2010  0.678
2011 Cluny NL, Chambers AP, Vemuri VK, Wood JT, Eller LK, Freni C, Reimer RA, Makriyannis A, Sharkey KA. The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat. Pharmacology, Biochemistry, and Behavior. 97: 537-43. PMID 21056053 DOI: 10.1016/J.Pbb.2010.10.013  0.791
2011 Shi M, Wang A, Prescott D, Waterhouse CC, Zhang S, McDougall JJ, Sharkey KA, McKay DM. Infection with an intestinal helminth parasite reduces Freund's complete adjuvant-induced monoarthritis in mice. Arthritis and Rheumatism. 63: 434-44. PMID 20967852 DOI: 10.1002/Art.30098  0.476
2011 Duncan M, Thomas A, Cluny N, Patel A, Patel K, Lutz B, Piomelli D, Alexander S, Sharkey K. Distribution and function of monoacylglycerol lipase in the gastrointestinal tract (vol 295, pg G1255, 2008) American Journal of Physiology-Gastrointestinal and Liver Physiology. 301. DOI: 10.1152/Ajpgi.Zh3-5964-Corr.2011  0.744
2011 de Heuvel E, Wallace L, Sharkey KA, Sigalet DL. Glucagon-Like Peptide 2 Induces Neuronal Proliferation via an Activation Dependent, but cAMP Independent Pathway Gastroenterology. 140: S-197. DOI: 10.1016/S0016-5085(11)60796-8  0.304
2011 Bashashati M, Hu H, Keenan CM, Cravatt BF, Sharkey KA. N-Acylphosphatidylethanolamines as Novel Regulators of Gastrointestinal Motility in the Mouse Gastroenterology. 140: S-100. DOI: 10.1016/S0016-5085(11)60407-1  0.587
2010 Cluny NL, Vemuri VK, Chambers AP, Limebeer CL, Bedard H, Wood JT, Lutz B, Zimmer A, Parker LA, Makriyannis A, Sharkey KA. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents. British Journal of Pharmacology. 161: 629-42. PMID 20880401 DOI: 10.1111/J.1476-5381.2010.00908.X  0.799
2010 Sigalet DL, Wallace L, De Heuval E, Sharkey KA. The effects of glucagon-like peptide 2 on enteric neurons in intestinal inflammation. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 22: 1318-e350. PMID 20718942 DOI: 10.1111/J.1365-2982.2010.01585.X  0.394
2010 Cluny NL, Keenan CM, Duncan M, Fox A, Lutz B, Sharkey KA. Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice. The Journal of Pharmacology and Experimental Therapeutics. 334: 973-80. PMID 20571060 DOI: 10.1124/Jpet.110.169946  0.8
2010 Klompus M, Ho W, Sharkey KA, McKay DM. Antisecretory effects of neuropeptide Y in the mouse colon are region-specific and are lost in DSS-induced colitis. Regulatory Peptides. 165: 138-45. PMID 20561896 DOI: 10.1016/J.Regpep.2010.05.014  0.793
2010 Gulbransen BD, Bains JS, Sharkey KA. Enteric glia are targets of the sympathetic innervation of the myenteric plexus in the guinea pig distal colon. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6801-9. PMID 20463242 DOI: 10.1523/Jneurosci.0603-10.2010  0.757
2010 Hyland NP, Rybicka JM, Ho W, Pittman QJ, Macnaughton WK, Sharkey KA. Adaptation of intestinal secretomotor function and nutrient absorption in response to diet-induced obesity. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 22: 602-e171. PMID 20426798 DOI: 10.1111/J.1365-2982.2010.01504.X  0.757
2010 Storr MA, Bashashati M, Hirota C, Vemuri VK, Keenan CM, Duncan M, Lutz B, Mackie K, Makriyannis A, Macnaughton WK, Sharkey KA. Differential effects of CB(1) neutral antagonists and inverse agonists on gastrointestinal motility in mice. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 22: 787-96, e223. PMID 20180825 DOI: 10.1111/J.1365-2982.2010.01478.X  0.783
2010 Patel KD, Davison JS, Pittman QJ, Sharkey KA. Cannabinoid CB(2) receptors in health and disease. Current Medicinal Chemistry. 17: 1393-410. PMID 20166925 DOI: 10.2174/092986710790980041  0.729
2010 Izzo AA, Sharkey KA. Cannabinoids and the gut: new developments and emerging concepts. Pharmacology & Therapeutics. 126: 21-38. PMID 20117132 DOI: 10.1016/J.Pharmthera.2009.12.005  0.381
2010 Strong DS, Cornbrooks CF, Roberts JA, Hoffman JM, Sharkey KA, Mawe GM. Purinergic neuromuscular transmission is selectively attenuated in ulcerated regions of inflamed guinea pig distal colon. The Journal of Physiology. 588: 847-59. PMID 20064853 DOI: 10.1113/Jphysiol.2009.185082  0.595
2010 Bueter M, Löwenstein C, Olbers T, Wang M, Cluny NL, Bloom SR, Sharkey KA, Lutz TA, le Roux CW. Gastric bypass increases energy expenditure in rats. Gastroenterology. 138: 1845-53. PMID 19931268 DOI: 10.1053/J.Gastro.2009.11.012  0.725
2010 Lomax AE, Sharkey KA, Furness JB. The participation of the sympathetic innervation of the gastrointestinal tract in disease states. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 22: 7-18. PMID 19686308 DOI: 10.1111/J.1365-2982.2009.01381.X  0.648
2010 Hoffman JM, McKnight ND, Brooks EM, Strong DS, Cornbrooks CF, Sharkey KA, Mawe GM. T2057 Increased Myenteric Neuronal Activity Contributes to Dysmotility in the Inflamed Guinea Pig Distal Colon Gastroenterology. 138: S-622-S-623. DOI: 10.1016/S0016-5085(10)62870-3  0.569
2010 Roberts JA, Strong DS, Hoffman JM, Cornbrooks CF, Sharkey KA, Mawe GM. T2056 Purinergic Inhibitory Junction Potentials are Selectively Attenuated in Regions of Disrupted Motility in the Inflamed Guinea Pig Distal Colon Gastroenterology. 138: S-622. DOI: 10.1016/S0016-5085(10)62869-7  0.534
2010 Martin GR, Keenan CM, Sharkey KA, Jirik F. S1735 Over-Expression of the Endogenous Prion Protein (PrpC) Attenuates Experimentally-Induced Colitis Gastroenterology. 138: S-263. DOI: 10.1016/S0016-5085(10)61205-X  0.518
2010 Martin GR, Bashashati M, Keenan CM, MacNaughton WK, Jirik F, Sharkey KA. 724 The Functional Role of Cellular Prion Protein in the Enteric Nervous System Gastroenterology. 138: S-97. DOI: 10.1016/S0016-5085(10)60445-3  0.633
2009 Hyland NP, Chambers AP, Keenan CM, Pittman QJ, Sharkey KA. Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental colitis? American Journal of Physiology. Gastrointestinal and Liver Physiology. 297: G869-77. PMID 20501435 DOI: 10.1152/Ajpgi.00164.2009  0.798
2009 Fichna J, Schicho R, Andrews CN, Bashashati M, Klompus M, McKay DM, Sharkey KA, Zjawiony JK, Janecka A, Storr MA. Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating kappa-opioid and cannabinoid receptors. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 21: 1326-e128. PMID 19650775 DOI: 10.1111/J.1365-2982.2009.01369.X  0.796
2009 Storr MA, Keenan CM, Zhang H, Patel KD, Makriyannis A, Sharkey KA. Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis. Inflammatory Bowel Diseases. 15: 1678-85. PMID 19408320 DOI: 10.1002/Ibd.20960  0.565
2009 Mawe GM, Strong DS, Sharkey KA. Plasticity of enteric nerve functions in the inflamed and postinflamed gut. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 21: 481-91. PMID 19368664 DOI: 10.1111/J.1365-2982.2009.01291.X  0.609
2009 Gulbransen BD, Sharkey KA. Purinergic neuron-to-glia signaling in the enteric nervous system. Gastroenterology. 136: 1349-58. PMID 19250649 DOI: 10.1053/J.Gastro.2008.12.058  0.694
2009 Hons IM, Burda JE, Grider JR, Mawe GM, Sharkey KA. Alterations to enteric neural signaling underlie secretory abnormalities of the ileum in experimental colitis in the guinea pig. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G717-26. PMID 19221017 DOI: 10.1152/Ajpgi.90472.2008  0.804
2009 Cluny NL, Keenan CM, Lutz B, Piomelli D, Sharkey KA. The identification of peroxisome proliferator-activated receptor alpha-independent effects of oleoylethanolamide on intestinal transit in mice. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 21: 420-9. PMID 19140957 DOI: 10.1016/S0016-5085(08)61141-5  0.777
2009 Kunos G, Osei-Hyiaman D, Bátkai S, Sharkey KA, Makriyannis A. Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? Trends in Pharmacological Sciences. 30: 1-7. PMID 19042036 DOI: 10.1016/J.Tips.2008.10.001  0.327
2009 Smith PM, Chambers AP, Price CJ, Ho W, Hopf C, Sharkey KA, Ferguson AV. The subfornical organ: a central nervous system site for actions of circulating leptin. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R512-20. PMID 19020290 DOI: 10.1152/Ajpregu.90858.2008  0.767
2009 Storr M, Bashashati M, Vemuri K, Alapafuja S, Ho W, Keenan CM, Kunos G, Makriyannis A, Davison JS, Sharkey KA. W1697 Regional Specificity of Fatty Acid Amide Hydrolase (FAAH) Inhibition On Contractility in the Mouse Intestine: Endotoxin Upregulation of Faah Sensitivity in the Ileum Gastroenterology. 136: A-719. DOI: 10.1016/S0016-5085(09)63320-5  0.718
2009 Klompus M, Sharkey KA, McKay DM. W1655 Neuropeptide Y Regulates Epithelial Ion Transport in the Mouse Colon in a Region-Specific Manner: Anti-Secretory Actions Are Lost in Colitis Gastroenterology. 136: A-711. DOI: 10.1016/S0016-5085(09)63279-0  0.775
2009 Hons IM, Lutz B, Sharkey KA. 28 Cannabinoids Are Retrograde Transmitters in the Myenteric Plexus Gastroenterology. 136: A-3-A-4. DOI: 10.1016/S0016-5085(09)60019-6  0.778
2008 Riazi K, Galic MA, Kuzmiski JB, Ho W, Sharkey KA, Pittman QJ. Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation. Proceedings of the National Academy of Sciences of the United States of America. 105: 17151-6. PMID 18955701 DOI: 10.1073/Pnas.0806682105  0.666
2008 Duncan M, Thomas AD, Cluny NL, Patel A, Patel KD, Lutz B, Piomelli D, Alexander SP, Sharkey KA. Distribution and function of monoacylglycerol lipase in the gastrointestinal tract. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G1255-65. PMID 18948437 DOI: 10.1152/Ajpgi.90500.2008  0.795
2008 Storr MA, Yüce B, Andrews CN, Sharkey KA. The role of the endocannabinoid system in the pathophysiology and treatment of irritable bowel syndrome. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 20: 857-68. PMID 18710476 DOI: 10.1111/J.1365-2982.2008.01175.X  0.531
2008 Aulí M, Nasser Y, Ho W, Burgueño JF, Keenan CM, Romero C, Sharkey KA, Fernández E. Neuromuscular changes in a rat model of colitis. Autonomic Neuroscience : Basic & Clinical. 141: 10-21. PMID 18534920 DOI: 10.1016/J.Autneu.2008.04.005  0.642
2008 Storr MA, Keenan CM, Emmerdinger D, Zhang H, Yüce B, Sibaev A, Massa F, Buckley NE, Lutz B, Göke B, Brand S, Patel KD, Sharkey KA. Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors. Journal of Molecular Medicine (Berlin, Germany). 86: 925-36. PMID 18493729 DOI: 10.1007/S00109-008-0359-6  0.54
2008 Duncan M, Mouihate A, Mackie K, Keenan CM, Buckley NE, Davison JS, Patel KD, Pittman QJ, Sharkey KA. Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G78-G87. PMID 18483180 DOI: 10.1152/Ajpgi.90285.2008  0.812
2008 Miller MJ, Reuter BK, Wallace JL, Sharkey KA. A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. Journal of Translational Medicine. 6: 3. PMID 18205911 DOI: 10.1186/1479-5876-6-3  0.351
2008 Wright KL, Duncan M, Sharkey KA. Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation. British Journal of Pharmacology. 153: 263-70. PMID 17906675 DOI: 10.1038/sj.bjp.0707486  0.507
2008 Ferguson AV, Sharkey KA. How satiety factors reach CNS appetite centers Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 8: 286-291. DOI: 10.2174/187152208787169143  0.534
2008 Duncan M, Thomas AD, Patel KD, Piomelli D, Sharkey KA. W1350 the Distribution and Function of Monoacylglycerol Lipase, An Endogenous Cannabinoid Inactivation Enzyme, in the Enteric Nervous System Gastroenterology. 134: A-686. DOI: 10.1016/S0016-5085(08)63200-X  0.464
2008 Wallace LE, Sharkey KA, Sigalet D. T1378 GLP-2 Treatment Protects Against Neuronal Loss and Enhances the Expression of VIP in the Submucosal Plexus in TNBS Colitis Gastroenterology. 134: A-542. DOI: 10.1016/S0016-5085(08)62532-9  0.308
2008 Hons IM, Keenan CM, Storr M, Lutz B, Sharkey KA. M1239 Alterations in Synaptic Transmission in the Enteric Nervous System and Correlation to Motility Defects in CB1 Receptor-Deficient Mice Gastroenterology. 134: A-368. DOI: 10.1016/S0016-5085(08)61715-1  0.782
2008 Storr M, Keenan CM, Zhang H, Patel KD, Sharkey KA. S1737 Drugs Inhibiting Endocannabinoid Degradation Protect Against Experimental Colitis in Mice Gastroenterology. 134: A-260. DOI: 10.1016/S0016-5085(08)61208-1  0.463
2007 Krauter EM, Strong DS, Brooks EM, Linden DR, Sharkey KA, Mawe GM. Changes in colonic motility and the electrophysiological properties of myenteric neurons persist following recovery from trinitrobenzene sulfonic acid colitis in the guinea pig. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 19: 990-1000. PMID 17973636 DOI: 10.1111/J.1365-2982.2007.00986.X  0.568
2007 Chambers AP, Vemuri VK, Peng Y, Wood JT, Olszewska T, Pittman QJ, Makriyannis A, Sharkey KA. A neutral CB1 receptor antagonist reduces weight gain in rat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R2185-93. PMID 17959701 DOI: 10.1152/Ajpregu.00663.2007  0.776
2007 Storr MA, Sharkey KA. The endocannabinoid system and gut-brain signalling. Current Opinion in Pharmacology. 7: 575-82. PMID 17904903 DOI: 10.1016/j.coph.2007.08.008  0.485
2007 O'Hara JR, Sharkey KA. Proliferative capacity of enterochromaffin cells in guinea-pigs with experimental ileitis. Cell and Tissue Research. 329: 433-41. PMID 17508220 DOI: 10.1007/s00441-007-0430-6  0.44
2007 Hyland NP, Pittman QJ, Sharkey KA. Peptide YY containing enteroendocrine cells and peripheral tissue sensitivity to PYY and PYY(3-36) are maintained in diet-induced obese and diet-resistant rats. Peptides. 28: 1185-90. PMID 17475366 DOI: 10.1016/J.Peptides.2007.03.011  0.749
2007 Sharkey KA, Cristino L, Oland LD, Van Sickle MD, Starowicz K, Pittman QJ, Guglielmotti V, Davison JS, Di Marzo V. Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret. The European Journal of Neuroscience. 25: 2773-82. PMID 17459108 DOI: 10.1111/J.1460-9568.2007.05521.X  0.797
2007 Nasser Y, Keenan CM, Ma AC, McCafferty DM, Sharkey KA. Expression of a functional metabotropic glutamate receptor 5 on enteric glia is altered in states of inflammation. Glia. 55: 859-72. PMID 17405149 DOI: 10.1002/Glia.20507  0.606
2007 Sigalet DL, Wallace LE, Holst JJ, Martin GR, Kaji T, Tanaka H, Sharkey KA. Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2. American Journal of Physiology. Gastrointestinal and Liver Physiology. 293: G211-21. PMID 17395898 DOI: 10.1152/Ajpgi.00530.2006  0.54
2007 Krauter EM, Linden DR, Sharkey KA, Mawe GM. Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation. The Journal of Physiology. 581: 787-800. PMID 17363386 DOI: 10.1113/Jphysiol.2007.128082  0.516
2007 Lomax AE, O'Hara JR, Hyland NP, Mawe GM, Sharkey KA. Persistent alterations to enteric neural signaling in the guinea pig colon following the resolution of colitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G482-91. PMID 17008554 DOI: 10.1152/Ajpgi.00355.2006  0.815
2007 Spencer SJ, Hyland NP, Sharkey KA, Pittman QJ. Neonatal immune challenge exacerbates experimental colitis in adult rats: potential role for TNF-alpha. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 292: R308-15. PMID 16973935 DOI: 10.1152/Ajpregu.00398.2006  0.757
2007 O'Hara JR, Lomax AE, Mawe GM, Sharkey KA. Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon. Gut. 56: 186-94. PMID 16931576 DOI: 10.1136/Gut.2006.102780  0.762
2007 Mawe GM, Strong DS, Krauter EM, Sharkey KA. The enteric nervous system: Inflammation-induced changes in neuronal function and related changes in motility Nihon Heikatsukingakkaizassi. 11: J1-J51. DOI: 10.1540/HEIKATSUKINZASHI.11.J1  0.525
2007 Auli M, Nasser Y, Ho W, Keenan C, Burgueño J, Romero C, Sharkey K, Fernandez E. P167 CHARACTERIZATION OF THE NEUROCHEMICAL AND NEUROMUSCULAR ADAPTIONS IN A RAT MODEL OF ULCERATIVE COLITIS Journal of Crohn's and Colitis Supplements. 1: 46. DOI: 10.1016/S1873-9954(07)70179-9  0.546
2006 Sharkey KA. From fat to full: peripheral and central mechanisms controlling food intake and energy balance: view from the chair. Obesity (Silver Spring, Md.). 14: 239S-241S. PMID 17021374 DOI: 10.1038/Oby.2006.316  0.318
2006 Fry M, Smith PM, Hoyda TD, Duncan M, Ahima RS, Sharkey KA, Ferguson AV. Area postrema neurons are modulated by the adipocyte hormone adiponectin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9695-702. PMID 16988040 DOI: 10.1523/Jneurosci.2014-06.2006  0.672
2006 Nasser Y, Fernandez E, Keenan CM, Ho W, Oland LD, Tibbles LA, Schemann M, MacNaughton WK, Rühl A, Sharkey KA. Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function. American Journal of Physiology. Gastrointestinal and Liver Physiology. 291: G912-27. PMID 16798727 DOI: 10.1152/Ajpgi.00067.2006  0.673
2006 Lomax AE, Linden DR, Mawe GM, Sharkey KA. Effects of gastrointestinal inflammation on enteroendocrine cells and enteric neural reflex circuits. Autonomic Neuroscience : Basic & Clinical. 126: 250-7. PMID 16616704 DOI: 10.1016/J.Autneu.2006.02.015  0.703
2006 O'Hara JR, Skinn AC, MacNaughton WK, Sherman PM, Sharkey KA. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cellular Microbiology. 8: 646-60. PMID 16548890 DOI: 10.1111/J.1462-5822.2005.00657.X  0.515
2006 Nasser Y, Ho W, Sharkey KA. Distribution of adrenergic receptors in the enteric nervous system of the guinea pig, mouse, and rat. The Journal of Comparative Neurology. 495: 529-53. PMID 16498685 DOI: 10.1002/Cne.20898  0.625
2006 Davies GA, Bryant AR, Reynolds JD, Jirik FR, Sharkey KA. Prion diseases and the gastrointestinal tract. Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. 20: 18-24. PMID 16432555 DOI: 10.1155/2006/184528  0.303
2006 Sharkey KA. Visceral sensation and colitis: inflammation and hypersensitivity do not always go hand in hand. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 18: 87-90. PMID 16420286 DOI: 10.1111/J.1365-2982.2005.00743.X  0.341
2006 Chambers AP, Koopmans HS, Pittman QJ, Sharkey KA. AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion. British Journal of Pharmacology. 147: 109-16. PMID 16258524 DOI: 10.1038/Sj.Bjp.0706439  0.78
2005 Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N, Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD, Sharkey KA. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (New York, N.Y.). 310: 329-32. PMID 16224028 DOI: 10.1126/Science.1115740  0.798
2005 Duncan M, Davison JS, Sharkey KA. Review article: endocannabinoids and their receptors in the enteric nervous system. Alimentary Pharmacology & Therapeutics. 22: 667-83. PMID 16197488 DOI: 10.1111/J.1365-2036.2005.02648.X  0.653
2005 Linden DR, Couvrette JM, Ciolino A, McQuoid C, Blaszyk H, Sharkey KA, Mawe GM. Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 17: 751-60. PMID 16185315 DOI: 10.1111/J.1365-2982.2005.00703.X  0.578
2005 Linden DR, Foley KF, McQuoid C, Simpson J, Sharkey KA, Mawe GM. Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 17: 565-74. PMID 16078946 DOI: 10.1111/J.1365-2982.2005.00673.X  0.506
2005 Natah SS, Mouihate A, Pittman QJ, Sharkey KA. Disruption of the blood-brain barrier during TNBS colitis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 17: 433-46. PMID 15916631 DOI: 10.1111/J.1365-2982.2005.00654.X  0.786
2005 Sharkey KA, Pittman QJ. Central and peripheral signaling mechanisms involved in endocannabinoid regulation of feeding: a perspective on the munchies. Science's Stke : Signal Transduction Knowledge Environment. 2005: pe15. PMID 15798103 DOI: 10.1126/Stke.2772005Pe15  0.61
2005 Lomax AE, Mawe GM, Sharkey KA. Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis in guinea-pig. The Journal of Physiology. 564: 863-75. PMID 15774518 DOI: 10.1113/Jphysiol.2005.084285  0.67
2005 Lomax AE, Fernández E, Sharkey KA. Plasticity of the enteric nervous system during intestinal inflammation. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 17: 4-15. PMID 15670258 DOI: 10.1111/j.1365-2982.2004.00607.x  0.537
2005 Buresi MC, Vergnolle N, Sharkey KA, Keenan CM, Andrade-Gordon P, Cirino G, Cirillo D, Hollenberg MD, MacNaughton WK. Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro. American Journal of Physiology. Gastrointestinal and Liver Physiology. 288: G337-45. PMID 15345469 DOI: 10.1152/Ajpgi.00112.2004  0.301
2004 Chambers AP, Sharkey KA, Koopmans HS. Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat. Physiology & Behavior. 82: 863-9. PMID 15451651 DOI: 10.1016/J.Physbeh.2004.07.004  0.77
2004 Sharkey KA, Nasser Y, Ruhl A. Enteric glia. Gut. 53: 1390. PMID 15306610  0.551
2004 Natah SS, Konttinen YT, Enattah NS, Ashammakhi N, Sharkey KA, Häyrinen-Immonen R. Recurrent aphthous ulcers today: a review of the growing knowledge. International Journal of Oral and Maxillofacial Surgery. 33: 221-34. PMID 15287304 DOI: 10.1006/ijom.2002.0446  0.713
2004 Hirasawa M, Schwab Y, Natah S, Hillard CJ, Mackie K, Sharkey KA, Pittman QJ. Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain. The Journal of Physiology. 559: 611-24. PMID 15254151 DOI: 10.1113/Jphysiol.2004.066159  0.803
2004 Mathison R, Ho W, Pittman QJ, Davison JS, Sharkey KA. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. British Journal of Pharmacology. 142: 1247-54. PMID 15249429 DOI: 10.1038/Sj.Bjp.0705889  0.734
2004 O'Hara JR, Ho W, Linden DR, Mawe GM, Sharkey KA. Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G998-1007. PMID 15231483 DOI: 10.1152/Ajpgi.00090.2004  0.652
2004 De Giorgio R, Guerrini S, Barbara G, Stanghellini V, De Ponti F, Corinaldesi R, Moses PL, Sharkey KA, Mawe GM. Inflammatory neuropathies of the enteric nervous system. Gastroenterology. 126: 1872-83. PMID 15188182 DOI: 10.1053/J.Gastro.2004.02.024  0.59
2004 Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology. 126: 1657-64. PMID 15188158 DOI: 10.1053/J.Gastro.2004.03.013  0.553
2004 Green CL, Ho W, Sharkey KA, McKay DM. Dextran sodium sulfate-induced colitis reveals nicotinic modulation of ion transport via iNOS-derived NO. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G706-14. PMID 15087277 DOI: 10.1152/Ajpgi.00076.2004  0.542
2004 Rühl A, Nasser Y, Sharkey KA. Enteric glia. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 16: 44-9. PMID 15066004 DOI: 10.1111/j.1743-3150.2004.00474.x  0.634
2004 Linden DR, Sharkey KA, Ho W, Mawe GM. Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon. The Journal of Physiology. 557: 191-205. PMID 15020692 DOI: 10.1113/Jphysiol.2004.062174  0.604
2004 Sayani FA, Keenan CM, Van Sickle MD, Amundson KR, Parr EJ, Mathison RD, MacNaughton WK, Braun JE, Sharkey KA. The expression and role of Fas ligand in intestinal inflammation. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 16: 61-74. PMID 14764206 DOI: 10.1046/J.1365-2982.2003.00457.X  0.8
2004 MacNaughton WK, Van Sickle MD, Keenan CM, Cushing K, Mackie K, Sharkey KA. Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves. American Journal of Physiology. Gastrointestinal and Liver Physiology. 286: G863-71. PMID 14701723 DOI: 10.1152/Ajpgi.00482.2003  0.798
2003 Lomax AE, Sharkey KA, Giles WR. Neuropeptide y modulates L-type Ca2+ current during heart development. Circulation Research. 93: 891-2. PMID 14615491 DOI: 10.1161/01.Res.0000103310.15593.C5  0.504
2003 Tjwa ET, Bradley JM, Keenan CM, Kroese AB, Sharkey KA. Interleukin-1beta activates specific populations of enteric neurons and enteric glia in the guinea pig ileum and colon. American Journal of Physiology. Gastrointestinal and Liver Physiology. 285: G1268-76. PMID 12881225 DOI: 10.1152/Ajpgi.00073.2003  0.314
2003 Van Sickle MD, Oland LD, Mackie K, Davison JS, Sharkey KA. Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets. American Journal of Physiology. Gastrointestinal and Liver Physiology. 285: G566-76. PMID 12791597 DOI: 10.1152/Ajpgi.00113.2003  0.798
2003 Moses PL, Ellis LM, Anees MR, Ho W, Rothstein RI, Meddings JB, Sharkey KA, Mawe GM. Antineuronal antibodies in idiopathic achalasia and gastro-oesophageal reflux disease. Gut. 52: 629-36. PMID 12692044 DOI: 10.1136/Gut.52.5.629  0.546
2003 Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 285: G207-16. PMID 12646422 DOI: 10.1152/Ajpgi.00488.2002  0.543
2003 Boissé L, Van Sickle MD, Sharkey KA, Pittman QJ. Compromised neuroimmune status in rats with experimental colitis. The Journal of Physiology. 548: 929-39. PMID 12640019 DOI: 10.1111/J.1469-7793.2003.00929.X  0.781
2003 Linden DR, Sharkey KA, Mawe GM. Enhanced excitability of myenteric AH neurones in the inflamed guinea-pig distal colon. The Journal of Physiology. 547: 589-601. PMID 12562910 DOI: 10.1113/Jphysiol.2002.035147  0.588
2003 Moses PL, Coates MD, Mahoney CR, Sampson JE, Linden DR, Chen JJ, Newton EB, Sharkey KA, Crowell MD, Gershon MD, Mawe GM. KEY ELEMENTS OF SEROTONIN SIGNALING ARE ALTERED IN IBD AND IBS: SUPPORT FOR A MOLECULAR BASIS OF THE IRRITABLE BOWEL SYNDROME American Journal of Gastroenterology. 98: S262-S263. DOI: 10.1111/j.1572-0241.2003.08529.x  0.478
2003 Oland LD, Davison JS, Sharkey KA. Endocannabinoids inhibit emesis in the ferret Gastroenterology. 124: A669. DOI: 10.1016/S0016-5085(03)83389-9  0.497
2003 Natah S, Sharkey KA. Effect of TNBS-induced colitis on the permeability of the blood-brain barrier in the rat Gastroenterology. 124: A668. DOI: 10.1016/S0016-5085(03)83384-X  0.734
2003 Nasser Y, Orton S, Ho W, Sharkey KA. The distribution of alpha 2A adrenergic receptors in the enteric nervous system of the rat, mouse and guinea pig Gastroenterology. 124: A348. DOI: 10.1016/S0016-5085(03)81757-2  0.605
2003 Macnaughton WK, Cushing K, Van Sickle MD, Keenan CM, Mackie K, Sharkey KA. Cannabinoid CB1 receptor distribution and function in neurally mediated chloride secretion in the guinea pig ileum Gastroenterology. 124: A342. DOI: 10.1016/S0016-5085(03)81726-2  0.534
2003 O'Hara JR, Ho W, Mawe GM, Sharkey KA. Serotonin content of the intestinal mucosa is altered in TNBS-induced ileitis in the guinea pig Gastroenterology. 124: A341. DOI: 10.1016/S0016-5085(03)81720-1  0.672
2003 Coates MD, Moses PL, Mahoney CR, Linden DR, Vecchio JA, Ferrentino N, Zubarik RS, Crowell MD, Sharkey KA, Mawe GM. Serotonin signaling in the mucosa of the human colon Gastroenterology. 124: A341. DOI: 10.1016/S0016-5085(03)81719-5  0.531
2003 Green C, Ho W, Sharkey K, McKay D. Activation of colonic nicotinic cholinergic receptors modulates ion transport via iNOS-derived nitric oxide Gastroenterology. 124: A310-A311. DOI: 10.1016/S0016-5085(03)81565-2  0.48
2003 Keenan CM, Esfandyari T, Sieghart W, Sharkey KA. Localization of a functional GABA-A receptor in the guinea pig myenteric plexus Gastroenterology. 124: A136. DOI: 10.1016/S0016-5085(03)80674-1  0.647
2003 Assen LM, Ran I, Pittman QJ, Sharkey KA. Central autonomic activation in TNBS-induced colitis Gastroenterology. 124: A116. DOI: 10.1016/S0016-5085(03)80572-3  0.634
2002 Sharkey KA, Mawe GM. Neuroimmune and epithelial interactions in intestinal inflammation. Current Opinion in Pharmacology. 2: 669-77. PMID 12482729 DOI: 10.1016/S1471-4892(02)00215-1  0.592
2002 Manning BP, Sharkey KA, Mawe GM. Effects of PGE2 in guinea pig colonic myenteric ganglia. American Journal of Physiology. Gastrointestinal and Liver Physiology. 283: G1388-97. PMID 12388206 DOI: 10.1152/Ajpgi.00141.2002  0.61
2002 Song D, Liu H, Sharkey KA, Lee SS. Hyperdynamic circulation in portal-hypertensive rats is dependent on central c-fos gene expression. Hepatology (Baltimore, Md.). 35: 159-66. PMID 11786972 DOI: 10.1053/Jhep.2002.30417  0.315
2001 Van Sickle MD, Oland LD, Ho W, Hillard CJ, Mackie K, Davison JS, Sharkey KA. Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret. Gastroenterology. 121: 767-74. PMID 11606489 DOI: 10.1053/Gast.2001.28466  0.801
2001 Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL. Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nature Medicine. 7: 821-6. PMID 11433347 DOI: 10.1038/89945  0.383
2001 Zochodne DW, Cheng C, Miampamba M, Hargreaves K, Sharkey KA. Peptide accumulations in proximal endbulbs of transected axons. Brain Research. 902: 40-50. PMID 11376593 DOI: 10.1016/S0006-8993(01)02310-1  0.692
2001 Miampamba M, Yang H, Sharkey KA, Taché Y. Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats. American Journal of Physiology. Gastrointestinal and Liver Physiology. 280: G979-91. PMID 11292608 DOI: 10.1152/Ajpgi.2001.280.5.G979  0.739
2001 Song D, Sharkey KA, Breitman DR, Zhang Y, Lee SS. Disordered central cardiovascular regulation in portal hypertensive and cirrhotic rats. American Journal of Physiology. Gastrointestinal and Liver Physiology. 280: G420-30. PMID 11171624 DOI: 10.1152/Ajpgi.2001.280.3.G420  0.313
2001 Sharkey KA, Kroese AB. Consequences of intestinal inflammation on the enteric nervous system: neuronal activation induced by inflammatory mediators. The Anatomical Record. 262: 79-90. PMID 11146431 DOI: 10.1002/1097-0185(20010101)262:1<79::Aid-Ar1013>3.0.Co;2-K  0.389
2000 Barnett K, Bell CJ, McKnight W, Dicay M, Sharkey KA, Wallace JL. Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach. American Journal of Physiology. Gastrointestinal and Liver Physiology. 279: G1292-7. PMID 11093953 DOI: 10.1152/Ajpgi.2000.279.6.G1292  0.317
2000 Scott RB, Tan DT, Sharkey KA. Effect of splanchnectomy on jejunal motility and fos expression in brain stem after intestinal anaphylaxis in rat. American Journal of Physiology. Gastrointestinal and Liver Physiology. 279: G990-7. PMID 11052996 DOI: 10.1152/Ajpgi.2000.279.5.G990  0.358
2000 Esfandyari T, Macnaughton WK, Quirion R, St Pierre S, Junien JL, Sharkey KA. A novel receptor for calcitonin gene-related peptide (CGRP) mediates secretion in the rat colon: implications for secretory function in colitis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 1439-46. PMID 10877837 DOI: 10.1096/Fasebj.14.10.1439  0.669
2000 Moses PL, Ellis LM, Anees MR, Rothstein RI, Wood KM, Moses MC, Meddings JB, Ho W, Sharkey KA, Mawe GM. Serum from patients with achalasia contains antibodies directed against enteric, sympathetic, sensory and spinal neurons Gastroenterology. 118: A1190. DOI: 10.1016/S0016-5085(00)80589-2  0.531
1999 Miampamba M, Sharkey KA. c-Fos expression in the myenteric plexus, spinal cord and brainstem following injection of formalin in the rat colonic wall. Journal of the Autonomic Nervous System. 77: 140-51. PMID 10580296 DOI: 10.1016/S0165-1838(99)00048-X  0.725
1999 McCafferty DM, Miampamba M, Sihota E, Sharkey KA, Kubes P. Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice. Gut. 45: 864-73. PMID 10562585  0.704
1999 McKay DM, Lu J, Jedrzkiewicz S, Ho W, Sharkey KA. Nitric oxide participates in the recovery of normal jejunal epithelial ion transport following exposure to the superantigen, Staphylococcus aureus enterotoxin B. Journal of Immunology (Baltimore, Md. : 1950). 163: 4519-26. PMID 10510395  0.411
1999 Vergnolle N, Hollenberg MD, Sharkey KA, Wallace JL. Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. British Journal of Pharmacology. 127: 1083-90. PMID 10455252 DOI: 10.1038/Sj.Bjp.0702634  0.337
1999 Miampamba M, Sharkey KA. Temporal distribution of neuronal and inducible nitric oxide synthase and nitrotyrosine during colitis in rats. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 11: 193-206. PMID 10354344 DOI: 10.1046/j.1365-2982.1999.00150.x  0.725
1999 Lomax AE, Sharkey KA, Bertrand PP, Low AM, Bornstein JC, Furness JB. Correlation of morphology, electrophysiology and chemistry of neurons in the myenteric plexus of the guinea-pig distal colon. Journal of the Autonomic Nervous System. 76: 45-61. PMID 10323306 DOI: 10.1016/S0165-1838(99)00008-9  0.623
1999 Sharkey KA, Parr EJ, Keenan CM. Immediate-early gene expression in the inferior mesenteric ganglion and colonic myenteric plexus of the guinea pig. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2755-64. PMID 10087087 DOI: 10.1523/Jneurosci.19-07-02755.1999  0.582
1998 Scott RB, Tan DTM, Miampamba M, Sharkey KA. Anaphylaxis-induced alterations in intestinal motility: role of extrinsic neural pathways. American Journal of Physiology. Gastrointestinal and Liver Physiology. 275: G812-G821. PMID 29591798 DOI: 10.1152/ajpgi.1998.275.4.G812  0.71
1998 Palmer JM, Wong-Riley M, Sharkey KA. Functional alterations in jejunal myenteric neurons during inflammation in nematode-infected guinea pigs. The American Journal of Physiology. 275: G922-35. PMID 9815020 DOI: 10.1152/Ajpgi.1998.275.5.G922  0.348
1998 Scott RB, Tan DT, Miampamba M, Sharkey KA. Anaphylaxis-induced alterations in intestinal motility: role of extrinsic neural pathways. The American Journal of Physiology. 275: G812-21. PMID 9756513 DOI: 10.1152/Ajpgi.1998.275.4.G812  0.729
1998 Sharkey KA, Lomax AE, Bertrand PP, Furness JB. Electrophysiology, shape, and chemistry of neurons that project from guinea pig colon to inferior mesenteric ganglia. Gastroenterology. 115: 909-18. PMID 9753494 DOI: 10.1016/S0016-5085(98)70263-X  0.592
1998 Miampamba M, Sharkey KA. Distribution of calcitonin gene-related peptide, somatostatin, substance P and vasoactive intestinal polypeptide in experimental colitis in rats. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 10: 315-29. PMID 9697106 DOI: 10.1046/j.1365-2982.1998.00111.x  0.702
1998 Wallace JL, Bak A, McKnight W, Asfaha S, Sharkey KA, MacNaughton WK. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity. Gastroenterology. 115: 101-9. PMID 9649464 DOI: 10.1016/S0016-5085(98)70370-1  0.333
1998 Singh J, Sharkey KA, Lea RW, Williams RM. Effects of neuropeptides on serotonin release and protein and peroxidase secretion in the isolated rat lacrimal gland. Advances in Experimental Medicine and Biology. 438: 145-51. PMID 9634878 DOI: 10.1007/978-1-4615-5359-5_20  0.325
1998 Miampamba M, Parr EJ, McCafferty DM, Wallace JL, Sharkey KA. Effect of intracolonic benzalkonium chloride on trinitrobenzene sulphonic acid-induced colitis in the rat. Alimentary Pharmacology & Therapeutics. 12: 219-28. PMID 9570256 DOI: 10.1046/j.1365-2036.1998.00311.x  0.767
1998 Wallace JL, McCafferty DM, Sharkey KA. Lack of beneficial effect of a tachykinin receptor antagonist in experimental colitis. Regulatory Peptides. 73: 95-101. PMID 9533813 DOI: 10.1016/S0167-0115(97)01064-1  0.386
1998 Bates SL, Sharkey KA, Meddings JB. Vagal involvement in dietary regulation of nutrient transport. The American Journal of Physiology. 274: G552-60. PMID 9530157 DOI: 10.1152/Ajpgi.1998.274.3.G552  0.303
1998 Miampamba M, Sharkey K. Expression of fos in the myenteric plexus and brainstem following acute colonic inflammation in the rat Gastroenterology. 114: A803. DOI: 10.1016/S0016-5085(98)83277-0  0.701
1998 Keenan C, Furness J, Sharkey K. Microtubule associated protein-2 occurs in specific enteric neurons of the guinea pig ileum Gastroenterology. 114: A775. DOI: 10.1016/S0016-5085(98)83170-3  0.468
1998 Esfandyari T, MacNaughton W, Quirion R, Pierre S, Sharkey K. The role of calcitonin gene-related peptide (CGRP) in colonic inflammation and secretion in the rat Gastroenterology. 114: A367. DOI: 10.1016/S0016-5085(98)81487-X  0.651
1998 Wallace JL, Bak A, McKnight W, Asfaha S, Sharkey KA, MacNaughton WK. An important contribution of cyclooxygenase-1 to inflammatory responses in rats and mice: Implications for gi toxicity Gastroenterology. 114: A327. DOI: 10.1016/S0016-5085(98)81326-7  0.339
1997 Dekkers JA, Kroese AB, Keenan CM, MacNaughton WK, Sharkey KA. Prostaglandin E2 activation of VIP secretomotor neurons in the guinea pig ileum. Journal of the Autonomic Nervous System. 66: 131-7. PMID 9406116 DOI: 10.1016/S0165-1838(97)00079-9  0.344
1997 Parr EJ, Myles EB, Hanani M, Seror D, Riabowol KT, Sharkey KA. Immunoreactivity for the Fas ligand in the mammalian enteric nervous system. Cell and Tissue Research. 290: 21-9. PMID 9377638 DOI: 10.1007/S004410050903  0.596
1997 Hickey MJ, Sharkey KA, Sihota EG, Reinhardt PH, Macmicking JD, Nathan C, Kubes P. Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 11: 955-64. PMID 9337148 DOI: 10.1096/Fasebj.11.12.9337148  0.318
1997 Bradley JS, Parr EJ, Sharkey KA. Effects of inflammation on cell proliferation in the myenteric plexus of the guinea-pig ileum. Cell and Tissue Research. 289: 455-61. PMID 9232824 DOI: 10.1007/S004410050891  0.567
1997 Parr EJ, Sharkey KA. Multiple mechanisms contribute to myenteric plexus ablation induced by benzalkonium chloride in the guinea-pig ileum. Cell and Tissue Research. 289: 253-64. PMID 9211828 DOI: 10.1007/S004410050872  0.588
1997 McCafferty DM, Wallace JL, Sharkey KA. Effects of chemical sympathectomy and sensory nerve ablation on experimental colitis in the rat. The American Journal of Physiology. 272: G272-80. PMID 9124351 DOI: 10.1152/Ajpgi.1997.272.2.G272  0.315
1997 Miampamba M, Tan DT, Oliver MR, Sharkey KA, Scott RB. Intestinal anaphylaxis induces Fos immunoreactivity in myenteric plexus of rat small intestine. The American Journal of Physiology. 272: G181-9. PMID 9038892 DOI: 10.1152/Ajpgi.1997.272.1.G181  0.733
1997 Krowicki ZK, Sharkey KA, Serron SC, Nathan NA, Hornby PJ. Distribution of nitric oxide synthase in rat dorsal vagal complex and effects of microinjection of nitric oxide compounds upon gastric motor function. The Journal of Comparative Neurology. 377: 49-69. PMID 8986872 DOI: 10.1002/(Sici)1096-9861(19970106)377:1<49::Aid-Cne6>3.0.Co;2-J  0.332
1996 Williams RM, Bauce L, Lea RW, Singh J, Sharkey KA. Secretion and serotonin release in the isolated rat lacrimal gland: the effects of substance P and calcitonin gene-related peptide. Journal of the Autonomic Nervous System. 61: 37-42. PMID 8912252 DOI: 10.1016/0165-1838(96)00031-8  0.304
1996 Jennings LJ, Salido GM, Pariente JA, Davison JS, Singh J, Sharkey KA. Control of exocrine secretion in the guinea-pig pancreas by histamine H3 receptors. Canadian Journal of Physiology and Pharmacology. 74: 744-52. PMID 8909787 DOI: 10.1139/cjpp-74-6-744  0.482
1996 Reuter BK, Asfaha S, Buret A, Sharkey KA, Wallace JL. Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2. The Journal of Clinical Investigation. 98: 2076-85. PMID 8903327 DOI: 10.1172/Jci119013  0.334
1996 Boissonade FM, Davison JS, Egizii R, Lucier GE, Sharkey KA. The dorsal vagal complex of the ferret: anatomical and immunohistochemical studies. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 8: 255-72. PMID 8878086 DOI: 10.1111/J.1365-2982.1996.Tb00265.X  0.531
1996 Parr EJ, Sharkey KA. Immunohistochemically-defined subtypes of neurons in the inferior mesenteric ganglion of the guinea-pig. Journal of the Autonomic Nervous System. 59: 140-50. PMID 8832520 DOI: 10.1016/0165-1838(96)00017-3  0.58
1996 Sharkey KA, Parr EJ. The Enteric Nervous System in Intestinal Inflammation Canadian Journal of Gastroenterology & Hepatology. 10: 335-341. DOI: 10.1007/978-94-009-0371-5_15  0.339
1996 Sharkey KA, Parr EJ. The enteric nervous system in intestinal inflammation | Le systeme nerveux enterique dans l'inflammation intestinale Canadian Journal of Gastroenterology. 10: 335-341.  0.504
1995 Jennings LJ, Salido GM, Pozo MJ, Davison JS, Sharkey KA, Lea RW, Singh J. The source and action of histamine in the isolated guinea-pig gallbladder. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 44: 447-53. PMID 8564521 DOI: 10.1007/Bf01757702  0.561
1995 Ferraz JG, McKnight W, Sharkey KA, Wallace JL. Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis. Gastroenterology. 108: 1183-91. PMID 7698587 DOI: 10.1016/0016-5085(95)90218-X  0.323
1994 Parr EJ, Gibson AW, Sharkey KA. c-Myc antigens in the mammalian enteric nervous system. Neuroscience. 58: 807-16. PMID 8190258 DOI: 10.1016/0306-4522(94)90458-8  0.554
1994 Williams RM, Singh J, Sharkey KA. Innervation and mast cells of the rat exorbital lacrimal gland: the effects of age. Journal of the Autonomic Nervous System. 47: 95-108. PMID 8188988 DOI: 10.1016/0165-1838(94)90070-1  0.303
1994 Boissonade FM, Sharkey KA, Davison JS. Fos expression in ferret dorsal vagal complex after peripheral emetic stimuli. The American Journal of Physiology. 266: R1118-26. PMID 8184953 DOI: 10.1152/Ajpregu.1994.266.4.R1118  0.553
1994 McCafferty DM, Sharkey KA, Wallace JL. Beneficial effects of local or systemic lidocaine in experimental colitis. The American Journal of Physiology. 266: G560-7. PMID 8178994 DOI: 10.1152/Ajpgi.1994.266.4.G560  0.391
1994 Parr EJ, Sharkey KA. The use of constitutive nuclear oncoproteins to count neurons in the enteric nervous system of the guinea pig. Cell and Tissue Research. 277: 325-31. PMID 8082123 DOI: 10.1007/Bf00327780  0.567
1994 Parr EJ, Sharkey KA. c-Fos- and JunB-immunoreactivities in the enteric nervous system of the guinea-pig ileum. Neuroreport. 5: 1657-61. PMID 7819542 DOI: 10.1097/00001756-199408150-00029  0.58
1994 MacNaughton WK, Leach KE, Prud'homme-Lalonde L, Ho W, Sharkey KA. Ionizing radiation reduces neurally evoked electrolyte transport in rat ileum through a mast cell-dependent mechanism. Gastroenterology. 106: 324-35. PMID 7507872 DOI: 10.1016/0016-5085(94)90589-4  0.334
1993 Parr EJ, Davison SN, Davison JS, Sharkey KA. The origin and distribution of neurons with projections passing through the inferior mesenteric ganglion of the guinea-pig. Journal of the Autonomic Nervous System. 44: 91-9. PMID 7693790 DOI: 10.1016/0165-1838(93)90021-L  0.672
1993 Pauletzki JG, Sharkey KA, Davison JS, Bomzon A, Shaffer EA. Involvement of L-arginine-nitric oxide pathways in neural relaxation of the sphincter of Oddi. European Journal of Pharmacology. 232: 263-70. PMID 7682181 DOI: 10.1016/0014-2999(93)90783-E  0.508
1992 Sharkey KA, Sutherland LR, Davison JS, Zwiers H, Gill MJ, Church DL. Peptides in the gastrointestinal tract in human immunodeficiency virus infection. The GI/HIV Study Group of the University of Calgary. Gastroenterology. 103: 18-28. PMID 1535325 DOI: 10.1016/0016-5085(92)91090-Q  0.501
1992 Harrington K, Bomzon A, Sharkey KA, Davison JS, Shaffer EA. Differential sensitivities of the sphincter of Oddi and gallbladder to cholecystokinin in the guinea pig: their role in transsphincteric bile flow. Canadian Journal of Physiology and Pharmacology. 70: 1336-41. PMID 1362689 DOI: 10.1139/Y92-187  0.531
1991 Sharkey KA, Gall DG, MacNaughton WK. Distribution and function of brain natriuretic peptide in the stomach and small intestine of the rat. Regulatory Peptides. 34: 61-70. PMID 1857779 DOI: 10.1016/0167-0115(91)90225-6  0.347
1991 Davison JS, McIntosh C, Sharkey KA. Evidence that vasoactive intestinal peptide (VIP) is an inhibitory transmitter in the ferret gastric corpus. Proceedings of the Western Pharmacology Society. 34: 417-9. PMID 1686329  0.47
1991 Sharkey KA, Oland LD, Kirk DR, Davison JS. Capsaicin-sensitive vagal stimulation-induced gastric acid secretion in the rat: evidence for cholinergic vagal afferents. British Journal of Pharmacology. 103: 1997-2003. PMID 1680518 DOI: 10.1111/J.1476-5381.1991.Tb12366.X  0.537
1990 Sharkey KA, Coggins PJ, Tetzlaff W, Zwiers H, Bisby MA, Davision JS. Distribution of growth-associated protein, B-50 (GAP-43) in the mammalian enteric nervous system. Neuroscience. 38: 13-20. PMID 2147742 DOI: 10.1016/0306-4522(90)90370-J  0.313
1989 Sharkey KA, Sobrino JA, Cervero F, Varro A, Dockray GJ. Visceral and somatic afferent origin of calcitonin gene-related peptide immunoreactivity in the lower thoracic spinal cord of the rat. Neuroscience. 32: 169-79. PMID 2586748 DOI: 10.1016/0306-4522(89)90116-4  0.592
1989 Sharkey KA, Mathison R, Sharif MN, Davison JS. The effects of streptozotocin-induced diabetes on the peptidergic innervation and function of the rat parotid gland. Journal of the Autonomic Nervous System. 27: 127-37. PMID 2476475 DOI: 10.1016/0165-1838(89)90094-5  0.526
1988 Cervero F, Sharkey KA. An electrophysiological and anatomical study of intestinal afferent fibres in the rat. The Journal of Physiology. 401: 381-97. PMID 3171991  0.498
1988 Davison J, Sharkey K, Egizii R, Lucier G. Distribution of neuropeptides in ferret brainstem areas activated by abdominal vagal stimulation Regulatory Peptides. 22: 399. DOI: 10.1016/0167-0115(88)90141-3  0.51
1987 Sharkey KA, Sobrino JA, Cervero F. Evidence for a visceral afferent origin of substance P-like immunoreactivity in lamina V of the rat thoracic spinal cord. Neuroscience. 22: 1077-83. PMID 2446196 DOI: 10.1016/0306-4522(87)92982-4  0.485
1986 Dockray GJ, Sharkey KA. Neurochemistry of visceral afferent neurones. Progress in Brain Research. 67: 133-48. PMID 3823469 DOI: 10.1016/S0079-6123(08)62760-0  0.434
1986 Sharkey KA, Cervero F. An in vitro method for recording single unit afferent activity from mesenteric nerves innervating isolated segments of rat ileum. Journal of Neuroscience Methods. 16: 149-56. PMID 3724230 DOI: 10.1016/0165-0270(86)90047-6  0.498
1985 Dockray GJ, Desmond H, Gayton RJ, Jonsson AC, Raybould H, Sharkey KA, Varro A, Williams RG. Cholecystokinin and gastrin forms in the nervous system. Annals of the New York Academy of Sciences. 448: 32-43. PMID 3861124  0.429
1985 Cervero F, Sharkey KA. More than just gut feelings about visceral sensation Trends in Neurosciences. 8: 188-190. DOI: 10.1016/0166-2236(85)90075-X  0.504
1984 Sharkey KA, Williams RG, Dockray GJ. Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing. Gastroenterology. 87: 914-21. PMID 6205934 DOI: 10.1016/0016-5085(84)90088-X  0.432
1983 Sharkey KA, Williams RG, Schultzberg M, Dockray GJ. Sensory substance P-innervation of the urinary bladder: possible site of action of capsaicin in causing urine retention in rats. Neuroscience. 10: 861-8. PMID 6196685 DOI: 10.1016/0306-4522(83)90223-3  0.433
1982 Sharkey K, Williams R, Schultzberg M, Dockray G. Sensory substance P (SP) innervation of the rat urinary bladder: Possible site of action of capsaicin in causing urine retention Regulatory Peptides. 4: 377. DOI: 10.1016/0167-0115(82)90191-4  0.411
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