Ruth Slack - Publications

Affiliations: 
Cellular and Molecular Medicine University of Ottawa, Ottawa, ON, Canada 
Area:
Neurogenesis - Neuronal cell death
Website:
http://www.med.uottawa.ca/ruthslack/

119 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Huang T, González YR, Qu D, Huang E, Safarpour F, Wang E, Joselin A, Im DS, Callaghan SM, Boonying W, Julian L, Dunwoodie SL, Slack RS, Park DS. The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors. The Journal of Biological Chemistry. PMID 30967472 DOI: 10.1074/jbc.RA119.007941  0.68
2019 Yang J, Kim KS, Iyirhiaro GO, Marcogliese PC, Callaghan SM, Qu D, Kim WJ, Slack RS, Park DS. DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress. Cell Death & Disease. 10: 135. PMID 30755590 DOI: 10.1038/s41419-019-1354-2  0.68
2019 Boonying W, Joselin A, Huang E, Qu D, Safarpour F, Iyirhiaro GO, Rodriguez Gonzalez Y, Callaghan SM, Slack RS, Figeys D, Chung YH, Park DS. Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP. Journal of Neurochemistry. PMID 30734931 DOI: 10.1111/jnc.14683  0.68
2018 Kim KS, Marcogliese PC, Yang J, Callaghan SM, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE, Park DS. Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29760073 DOI: 10.1073/pnas.1718946115  0.68
2018 Giguere N, Pacelli C, Saumure C, Bourque MJ, Matheoud D, Levesque D, Slack RS, Park DS, Trudeau LE. Comparative analysis of Parkinson's disease-associated genes reveals altered survival and bioenergetics of parkin-deficient dopamine neurons in mice. The Journal of Biological Chemistry. PMID 29700116 DOI: 10.1074/jbc.RA117.000499  0.68
2017 Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, ... ... Slack RS, et al. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death and Differentiation. PMID 29229998 DOI: 10.1038/s41418-017-0020-4  0.68
2017 Huang E, Qu D, Huang T, Rizzi N, Boonying W, Krolak D, Ciana P, Woulfe J, Klein C, Slack RS, Figeys D, Park DS. PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress. Nature Communications. 8: 1399. PMID 29123128 DOI: 10.1038/s41467-017-01435-1  0.68
2017 Iyirhiaro GO, Soon Im D, Boonying W, Callaghan SM, During MJ, Slack RS, Park DS. Cdc25A is a critical mediator of ischemic neuronal death in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28607169 DOI: 10.1523/JNEUROSCI.3017-16.2017  0.68
2017 Khacho M, Clark A, Svoboda DS, MacLaurin JG, Lagace DC, Park DS, Slack RS. Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis. Human Molecular Genetics. PMID 28595361 DOI: 10.1093/hmg/ddx217  0.68
2017 Marcogliese PC, Abuaish S, Kabbach G, Abdel-Messih E, Seang S, Li G, Slack RS, Emdadul Haque M, Venderova K, Park DS. LRRK2(I2020T) Functional Genetic Interactors that Modify Eye Degeneration and Dopaminergic Cell Loss in Drosophila. Human Molecular Genetics. PMID 28158614 DOI: 10.1093/hmg/ddx030  0.68
2016 Vandenbosch R, Clark A, Fong BC, Omais S, Jaafar C, Dugal-Tessier D, Dhaliwal J, Lagace DC, Park DS, Ghanem N, Slack RS. RB regulates the production and the survival of newborn neurons in the embryonic and adult dentate gyrus. Hippocampus. PMID 27325572 DOI: 10.1002/hipo.22613  0.68
2016 Khacho M, Clark A, Svoboda DS, Azzi J, MacLaurin JG, Meghaizel C, Sesaki H, Lagace DC, Germain M, Harper ME, Park DS, Slack RS. Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program. Cell Stem Cell. PMID 27237737 DOI: 10.1016/j.stem.2016.04.015  0.68
2015 Qu D, Hage A, Don-Carolis K, Huang E, Joselin A, Safarpour F, Marcogliese PC, Rousseaux MW, Hewitt SJ, Huang T, Im DS, Callaghan S, Dewar-Darch D, Figeys D, Slack RS, et al. Bag2 Mediated Regulation of Pink1 is Critical for Mitochondrial Translocation of Parkin and Neuronal Survival. The Journal of Biological Chemistry. PMID 26538564 DOI: 10.1074/jbc.M115.677815  0.68
2015 Svoboda D, Park DS, Slack RS. Role of the pRb family proteins in axon guidance and axon tract formation. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 47: 92. PMID 26531574 DOI: 10.1016/j.ijdevneu.2015.04.252  0.68
2015 Dugal-Tessier D, Vandenbosch R, Khacho M, Weijts B, Park DS, Leone G, de Bruin A, Slack RS. Absence of atypical E2f leads to ventriculomegaly. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 47: 14. PMID 26531370 DOI: 10.1016/j.ijdevneu.2015.04.048  0.68
2015 Antoun G, McMurray F, Thrush AB, Patten DA, Peixoto AC, Slack RS, McPherson R, Dent R, Harper ME. Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals. Diabetologia. 58: 2861-6. PMID 26404066 DOI: 10.1007/s00125-015-3772-8  0.68
2015 Pacelli C, Giguère N, Bourque MJ, Lévesque M, Slack RS, Trudeau LÉ. Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons. Current Biology : Cb. 25: 2349-60. PMID 26320949 DOI: 10.1016/j.cub.2015.07.050  0.68
2015 Jahani-Asl A, Huang E, Irrcher I, Rashidian J, Ishihara N, Lagace DC, Slack RS, Park DS. CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death. Human Molecular Genetics. 24: 4573-83. PMID 26002103 DOI: 10.1093/hmg/ddv188  0.68
2015 Julian LM, Liu Y, Pakenham CA, Dugal-Tessier D, Ruzhynsky V, Bae S, Tsai SY, Leone G, Slack RS, Blais A. Tissue-specific targeting of cell fate regulatory genes by E2f factors. Cell Death and Differentiation. PMID 25909886 DOI: 10.1038/cdd.2015.36  0.68
2015 Svoboda DS, Clark A, Park DS, Slack RS. Induction of protein deletion through in utero electroporation to define deficits in neuronal migration in transgenic models. Journal of Visualized Experiments : Jove. 51983. PMID 25650557 DOI: 10.3791/51983  0.68
2014 Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS. OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. The Embo Journal. 33: 2676-91. PMID 25298396 DOI: 10.15252/embj.201488349  0.68
2014 Parsanejad M, Bourquard N, Qu D, Zhang Y, Huang E, Rousseaux MW, Aleyasin H, Irrcher I, Callaghan S, Vaillant DC, Kim RH, Slack RS, Mak TW, Reddy ST, Figeys D, et al. DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. Plos One. 9: e106601. PMID 25210784 DOI: 10.1371/journal.pone.0106601  0.68
2014 Parsanejad M, Zhang Y, Qu D, Irrcher I, Rousseaux MW, Aleyasin H, Kamkar F, Callaghan S, Slack RS, Mak TW, Lee S, Figeys D, Park DS. Regulation of the VHL/HIF-1 pathway by DJ-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8043-50. PMID 24899725 DOI: 10.1523/JNEUROSCI.1244-13.2014  0.68
2014 Iyirhiaro GO, Zhang Y, Estey C, O'Hare MJ, Safarpour F, Parsanejad M, Wang S, Abdel-Messih E, Callaghan SM, During MJ, Slack RS, Park DS. Regulation of ischemic neuronal death by E2F4-p130 protein complexes. The Journal of Biological Chemistry. 289: 18202-13. PMID 24828495 DOI: 10.1074/jbc.M114.574145  0.68
2014 Khacho M, Tarabay M, Patten D, Khacho P, MacLaurin JG, Guadagno J, Bergeron R, Cregan SP, Harper ME, Park DS, Slack RS. Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival. Nature Communications. 5: 3550. PMID 24686499 DOI: 10.1038/ncomms4550  0.68
2013 Svoboda DS, Paquin A, Park DS, Slack RS. Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis. Developmental Biology. 384: 101-13. PMID 24056077 DOI: 10.1016/j.ydbio.2013.09.015  0.68
2013 Methot L, Hermann R, Tang Y, Lo R, Al-Jehani H, Jhas S, Svoboda D, Slack RS, Barker PA, Stifani S. Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis. Molecular and Cellular Biology. 33: 2797-808. PMID 23689134 DOI: 10.1128/MCB.01610-12  0.68
2013 Andrusiak MG, Vandenbosch R, Dick FA, Park DS, Slack RS. LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence. Cell Cycle (Georgetown, Tex.). 12: 1416-23. PMID 23574720 DOI: 10.4161/cc.24527  0.68
2013 Mount MP, Zhang Y, Amini M, Callaghan S, Kulczycki J, Mao Z, Slack RS, Anisman H, Park DS. Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The Journal of Biological Chemistry. 288: 14362-71. PMID 23536182 DOI: 10.1074/jbc.M112.439216  0.68
2013 Amini M, Ma CL, Farazifard R, Zhu G, Zhang Y, Vanderluit J, Zoltewicz JS, Hage F, Savitt JM, Lagace DC, Slack RS, Beique JC, Baudry M, Greer PA, Bergeron R, et al. Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 5773-84. PMID 23536090 DOI: 10.1523/JNEUROSCI.4247-12.2013  0.68
2013 Julian LM, Vandenbosch R, Pakenham CA, Andrusiak MG, Nguyen AP, McClellan KA, Svoboda DS, Lagace DC, Park DS, Leone G, Blais A, Slack RS. Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells. Cell Stem Cell. 12: 440-52. PMID 23499385 DOI: 10.1016/j.stem.2013.02.001  0.68
2013 Germain M, Nguyen AP, Khacho M, Patten DA, Screaton RA, Park DS, Slack RS. LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction. Human Molecular Genetics. 22: 952-62. PMID 23187960 DOI: 10.1093/hmg/dds500  0.68
2013 Rousseaux MWC, Marcogliese PC, Qu D, Hewitt SJ, Seang S, Kim RH, Slack RS, Schlossmacher MG, Lagace DC, Mak TW, Park DS. Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease (Proceedings of the National Academy of Sciences of the United States of America (2012) 109, 39 (15918-15923)) Proceedings of the National Academy of Sciences of the United States of America. 110: 11212. DOI: 10.1073/pnas.1310560110  0.68
2012 Andrusiak MG, Vandenbosch R, Park DS, Slack RS. The retinoblastoma protein is essential for survival of postmitotic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14809-14. PMID 23077065 DOI: 10.1523/JNEUROSCI.1912-12.2012  0.68
2012 Rousseaux MW, Marcogliese PC, Qu D, Hewitt SJ, Seang S, Kim RH, Slack RS, Schlossmacher MG, Lagace DC, Mak TW, Park DS. Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 109: 15918-23. PMID 23019375 DOI: 10.1073/pnas.1205102109  0.68
2012 Joselin AP, Hewitt SJ, Callaghan SM, Kim RH, Chung YH, Mak TW, Shen J, Slack RS, Park DS. ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Human Molecular Genetics. 21: 4888-903. PMID 22872702 DOI: 10.1093/hmg/dds325  0.68
2012 Ghanem N, Andrusiak MG, Svoboda D, Al Lafi SM, Julian LM, McClellan KA, De Repentigny Y, Kothary R, Ekker M, Blais A, Park DS, Slack RS. The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8219-30. PMID 22699903 DOI: 10.1523/JNEUROSCI.1344-12.2012  0.68
2012 Haque ME, Mount MP, Safarpour F, Abdel-Messih E, Callaghan S, Mazerolle C, Kitada T, Slack RS, Wallace V, Shen J, Anisman H, Park DS. Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. The Journal of Biological Chemistry. 287: 23162-70. PMID 22511790 DOI: 10.1074/jbc.M112.346437  0.68
2011 Lira A, Kulczycki J, Slack R, Anisman H, Park DS. Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss. The Journal of Biological Chemistry. 286: 28783-93. PMID 21693708 DOI: 10.1074/jbc.M111.244830  0.68
2011 Germain M, Slack RS. MCL-1 regulates the balance between autophagy and apoptosis. Autophagy. 7: 549-51. PMID 21412051 DOI: 10.4161/auto.7.5.15098  0.68
2011 Germain M, Nguyen AP, Le Grand JN, Arbour N, Vanderluit JL, Park DS, Opferman JT, Slack RS. MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. The Embo Journal. 30: 395-407. PMID 21139567 DOI: 10.1038/emboj.2010.327  0.68
2011 Andrusiak MG, McClellan KA, Dugal-Tessier D, Julian LM, Rodrigues SP, Park DS, Kennedy TE, Slack RS. Rb/E2F regulates expression of neogenin during neuronal migration. Molecular and Cellular Biology. 31: 238-47. PMID 21059867 DOI: 10.1128/MCB.00378-10  0.68
2011 Jahani-Asl A, Pilon-Larose K, Xu W, MacLaurin JG, Park DS, McBride HM, Slack RS. The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity. The Journal of Biological Chemistry. 286: 4772-82. PMID 21041314 DOI: 10.1074/jbc.M110.167155  0.68
2010 Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, ... ... Slack RS, et al. Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Human Molecular Genetics. 19: 3734-46. PMID 20639397 DOI: 10.1093/hmg/ddq288  0.68
2010 Huang E, Qu D, Zhang Y, Venderova K, Haque ME, Rousseaux MW, Slack RS, Woulfe JM, Park DS. The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death. Nature Cell Biology. 12: 563-71. PMID 20473298 DOI: 10.1038/ncb2058  0.68
2010 Patten DA, Germain M, Kelly MA, Slack RS. Reactive oxygen species: stuck in the middle of neurodegeneration. Journal of Alzheimer's Disease : Jad. 20: S357-67. PMID 20421690 DOI: 10.3233/JAD-2010-100498  0.68
2010 Biswas SC, Zhang Y, Iyirhiaro G, Willett RT, Rodriguez Gonzalez Y, Cregan SP, Slack RS, Park DS, Greene LA. Sertad1 plays an essential role in developmental and pathological neuron death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3973-82. PMID 20237268 DOI: 10.1523/JNEUROSCI.6421-09.2010  0.68
2010 Aleyasin H, Rousseaux MW, Marcogliese PC, Hewitt SJ, Irrcher I, Joselin AP, Parsanejad M, Kim RH, Rizzu P, Callaghan SM, Slack RS, Mak TW, Park DS. DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proceedings of the National Academy of Sciences of the United States of America. 107: 3186-91. PMID 20133695 DOI: 10.1073/pnas.0914876107  0.68
2010 Zhang Y, Parsanejad M, Huang E, Qu D, Aleyasin H, Rousseaux MW, Gonzalez YR, Cregan SP, Slack RS, Park DS. Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage. Journal of Neurochemistry. 112: 497-510. PMID 19895669 DOI: 10.1111/j.1471-4159.2009.06476.x  0.68
2010 Germain M, Slack RS. Dining in with BCL-2: new guests at the autophagy table. Clinical Science (London, England : 1979). 118: 173-81. PMID 19845510 DOI: 10.1042/CS20090310  0.68
2010 Jahani-Asl A, Germain M, Slack RS. Mitochondria: joining forces to thwart cell death. Biochimica Et Biophysica Acta. 1802: 162-6. PMID 19747972 DOI: 10.1016/j.bbadis.2009.09.006  0.68
2009 Rashidian J, Rousseaux MW, Venderova K, Qu D, Callaghan SM, Phillips M, Bland RJ, During MJ, Mao Z, Slack RS, Park DS. Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12497-505. PMID 19812325 DOI: 10.1523/JNEUROSCI.3892-09.2009  0.68
2009 Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS. Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Human Molecular Genetics. 18: 4390-404. PMID 19692353 DOI: 10.1093/hmg/ddp394  0.68
2009 McClellan KA, Vanderluit JL, Julian LM, Andrusiak MG, Dugal-Tessier D, Park DS, Slack RS. The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. Molecular and Cellular Biology. 29: 4701-13. PMID 19564414 DOI: 10.1128/MCB.01767-08  0.68
2009 Ruzhynsky VA, Furimsky M, Park DS, Wallace VA, Slack RS. E2F4 is required for early eye patterning. Developmental Neuroscience. 31: 238-46. PMID 19325228 DOI: 10.1159/000210186  0.68
2008 Arbour N, Vanderluit JL, Le Grand JN, Jahani-Asl A, Ruzhynsky VA, Cheung EC, Kelly MA, MacKenzie AE, Park DS, Opferman JT, Slack RS. Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6068-78. PMID 18550749 DOI: 10.1523/JNEUROSCI.4940-07.2008  0.68
2008 Jacobsen KX, Vanderluit JL, Slack RS, Albert PR. HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: essential role in developmental expression. Molecular and Cellular Neurosciences. 38: 349-58. PMID 18499474 DOI: 10.1016/j.mcn.2008.03.007  0.68
2008 Gonzalez YR, Zhang Y, Behzadpoor D, Cregan S, Bamforth S, Slack RS, Park DS. CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5559-69. PMID 18495890 DOI: 10.1523/JNEUROSCI.1014-08.2008  0.68
2008 Haque ME, Thomas KJ, D'Souza C, Callaghan S, Kitada T, Slack RS, Fraser P, Cookson MR, Tandon A, Park DS. Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proceedings of the National Academy of Sciences of the United States of America. 105: 1716-21. PMID 18218782 DOI: 10.1073/pnas.0705363105  0.68
2008 Iyirhiaro GO, Brust TB, Rashidian J, Galehdar Z, Osman A, Phillips M, Slack RS, Macvicar BA, Park DS. Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia. Journal of Neurochemistry. 105: 703-13. PMID 18205749 DOI: 10.1111/j.1471-4159.2007.05166.x  0.68
2008 Keramaris E, Ruzhynsky VA, Callaghan SM, Wong E, Davis RJ, Flavell R, Slack RS, Park DS. Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice. The Journal of Biological Chemistry. 283: 405-15. PMID 17984095 DOI: 10.1074/jbc.M701552200  0.68
2007 Aleyasin H, Rousseaux MW, Phillips M, Kim RH, Bland RJ, Callaghan S, Slack RS, During MJ, Mak TW, Park DS. The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Proceedings of the National Academy of Sciences of the United States of America. 104: 18748-53. PMID 18003894 DOI: 10.1073/pnas.0709379104  0.68
2007 McClellan KA, Slack RS. Specific in vivo roles for E2Fs in differentiation and development. Cell Cycle (Georgetown, Tex.). 6: 2917-27. PMID 17993781  0.68
2007 Jahani-Asl A, Slack RS. The phosphorylation state of Drp1 determines cell fate. Embo Reports. 8: 912-3. PMID 17906671 DOI: 10.1038/sj.embor.7401077  0.68
2007 Qu D, Rashidian J, Mount MP, Aleyasin H, Parsanejad M, Lira A, Haque E, Zhang Y, Callaghan S, Daigle M, Rousseaux MW, Slack RS, Albert PR, Vincent I, Woulfe JM, et al. Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron. 55: 37-52. PMID 17610816 DOI: 10.1016/j.neuron.2007.05.033  0.68
2007 Vanderluit JL, Wylie CA, McClellan KA, Ghanem N, Fortin A, Callaghan S, MacLaurin JG, Park DS, Slack RS. The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate. The Journal of Cell Biology. 178: 129-39. PMID 17591923 DOI: 10.1083/jcb.200703176  0.68
2007 Ruzhynsky VA, McClellan KA, Vanderluit JL, Jeong Y, Furimsky M, Park DS, Epstein DJ, Wallace VA, Slack RS. Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5926-35. PMID 17537963 DOI: 10.1523/JNEUROSCI.1538-07.2007  0.68
2007 Jahani-Asl A, Cheung EC, Neuspiel M, MacLaurin JG, Fortin A, Park DS, McBride HM, Slack RS. Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. The Journal of Biological Chemistry. 282: 23788-98. PMID 17537722 DOI: 10.1074/jbc.M703812200  0.68
2007 Cheung EC, McBride HM, Slack RS. Mitochondrial dynamics in the regulation of neuronal cell death. Apoptosis : An International Journal On Programmed Cell Death. 12: 979-92. PMID 17453163 DOI: 10.1007/s10495-007-0745-5  0.68
2007 McClellan KA, Ruzhynsky VA, Douda DN, Vanderluit JL, Ferguson KL, Chen D, Bremner R, Park DS, Leone G, Slack RS. Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Molecular and Cellular Biology. 27: 4825-43. PMID 17452454 DOI: 10.1128/MCB.02100-06  0.68
2007 Mount MP, Lira A, Grimes D, Smith PD, Faucher S, Slack R, Anisman H, Hayley S, Park DS. Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3328-37. PMID 17376993 DOI: 10.1523/JNEUROSCI.5321-06.2007  0.68
2007 Kennedy CR, Xiong H, Rahal S, Vanderluit J, Slack RS, Zhang Y, Guan Y, Breyer MD, Hébert RL. Urine concentrating defect in prostaglandin EP1-deficient mice. American Journal of Physiology. Renal Physiology. 292: F868-75. PMID 16885154 DOI: 10.1152/ajprenal.00183.2005  0.68
2007 Jahani-Asl A, Slack RS. Response by Arezu Jahani-Asl and Ruth S. Slack Embo Reports. 8: 1089-1090. DOI: 10.1038/sj.embor.7401119  0.68
2006 Zhang Y, Qu D, Morris EJ, O'Hare MJ, Callaghan SM, Slack RS, Geller HM, Park DS. The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8819-28. PMID 16928871 DOI: 10.1523/JNEUROSCI.2593-06.2006  0.68
2006 Cheung EC, Joza N, Steenaart NA, McClellan KA, Neuspiel M, McNamara S, MacLaurin JG, Rippstein P, Park DS, Shore GC, McBride HM, Penninger JM, Slack RS. Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. The Embo Journal. 25: 4061-73. PMID 16917506 DOI: 10.1038/sj.emboj.7601276  0.68
2006 McClellan KA, Slack RS. Novel functions for cell cycle genes in nervous system development. Cell Cycle (Georgetown, Tex.). 5: 1506-13. PMID 16861920  0.68
2006 Smith PD, Mount MP, Shree R, Callaghan S, Slack RS, Anisman H, Vincent I, Wang X, Mao Z, Park DS. Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 440-7. PMID 16407541 DOI: 10.1523/JNEUROSCI.2875-05.2006  0.68
2006 Crocker SJ, Hayley SP, Smith PD, Mount MP, Lamba WR, Callaghan SM, Slack RS, Park DS. Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase. Journal of Neurochemistry. 96: 489-99. PMID 16336220 DOI: 10.1111/j.1471-4159.2005.03568.x  0.68
2005 Ferguson KL, McClellan KA, Vanderluit JL, McIntosh WC, Schuurmans C, Polleux F, Slack RS. A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration. The Embo Journal. 24: 4381-91. PMID 16308563 DOI: 10.1038/sj.emboj.7600887  0.68
2005 O'Hare MJ, Kushwaha N, Zhang Y, Aleyasin H, Callaghan SM, Slack RS, Albert PR, Vincent I, Park DS. Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8954-66. PMID 16192386 DOI: 10.1523/JNEUROSCI.2899-05.2005  0.68
2005 Rashidian J, Iyirhiaro G, Aleyasin H, Rios M, Vincent I, Callaghan S, Bland RJ, Slack RS, During MJ, Park DS. Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 14080-5. PMID 16166266 DOI: 10.1073/pnas.0500099102  0.68
2005 Cheung EC, Melanson-Drapeau L, Cregan SP, Vanderluit JL, Ferguson KL, McIntosh WC, Park DS, Bennett SA, Slack RS. Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1324-34. PMID 15703386 DOI: 10.1523/JNEUROSCI.4261-04.2005  0.68
2005 Bérubé NG, Mangelsdorf M, Jagla M, Vanderluit J, Garrick D, Gibbons RJ, Higgs DR, Slack RS, Picketts DJ. The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. The Journal of Clinical Investigation. 115: 258-67. PMID 15668733 DOI: 10.1172/JCI22329  0.68
2005 Keramaris E, Vanderluit JL, Bahadori M, Mousavi K, Davis RJ, Flavell R, Slack RS, Park DS. c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. The Journal of Biological Chemistry. 280: 1132-41. PMID 15528206 DOI: 10.1074/jbc.M410127200  0.68
2004 Cregan SP, Arbour NA, Maclaurin JG, Callaghan SM, Fortin A, Cheung EC, Guberman DS, Park DS, Slack RS. p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10003-12. PMID 15525786 DOI: 10.1523/JNEUROSCI.2114-04.2004  0.68
2004 Cheung EC, Slack RS. Emerging role for ERK as a key regulator of neuronal apoptosis. Science's Stke : Signal Transduction Knowledge Environment. 2004: PE45. PMID 15383672 DOI: 10.1126/stke.2512004pe45  0.68
2004 Vanderluit JL, Ferguson KL, Nikoletopoulou V, Parker M, Ruzhynsky V, Alexson T, McNamara SM, Park DS, Rudnicki M, Slack RS. p107 regulates neural precursor cells in the mammalian brain. The Journal of Cell Biology. 166: 853-63. PMID 15353549 DOI: 10.1083/jcb.200403156  0.68
2004 Chen D, Livne-bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell. 5: 539-51. PMID 15193257 DOI: 10.1016/j.ccr.2004.05.025  0.68
2004 Fortin A, MacLaurin JG, Arbour N, Cregan SP, Kushwaha N, Callaghan SM, Park DS, Albert PR, Slack RS. The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1. The Journal of Biological Chemistry. 279: 28706-14. PMID 15105421 DOI: 10.1074/jbc.M400376200  0.68
2004 Cregan SP, Dawson VL, Slack RS. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene. 23: 2785-96. PMID 15077142 DOI: 10.1038/sj.onc.1207517  0.68
2004 Aleyasin H, Cregan SP, Iyirhiaro G, O'Hare MJ, Callaghan SM, Slack RS, Park DS. Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2963-73. PMID 15044535 DOI: 10.1523/JNEUROSCI.0155-04.2004  0.68
2004 Hayley S, Crocker SJ, Smith PD, Shree T, Jackson-Lewis V, Przedborski S, Mount M, Slack R, Anisman H, Park DS. Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2045-53. PMID 14985447 DOI: 10.1523/JNEUROSCI.4564-03.2004  0.68
2003 Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, Anisman H, Park DS. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 13650-5. PMID 14595022 DOI: 10.1073/pnas.2232515100  0.68
2003 Keramaris E, Hirao A, Slack RS, Mak TW, Park DS. Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage. The Journal of Biological Chemistry. 278: 37782-9. PMID 12857758 DOI: 10.1074/jbc.M304049200  0.68
2003 Ferguson KL, Slack RS. Growth factors: can they promote neurogenesis? Trends in Neurosciences. 26: 283-5. PMID 12798593 DOI: 10.1016/S0166-2236(03)00100-0  0.68
2003 Crocker SJ, Smith PD, Jackson-Lewis V, Lamba WR, Hayley SP, Grimm E, Callaghan SM, Slack RS, Melloni E, Przedborski S, Robertson GS, Anisman H, Merali Z, Park DS. Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4081-91. PMID 12764095  0.68
2003 Sedarous M, Keramaris E, O'Hare M, Melloni E, Slack RS, Elce JS, Greer PA, Park DS. Calpains mediate p53 activation and neuronal death evoked by DNA damage. The Journal of Biological Chemistry. 278: 26031-8. PMID 12721303 DOI: 10.1074/jbc.M302833200  0.68
2002 Fernando P, Kelly JF, Balazsi K, Slack RS, Megeney LA. Caspase 3 activity is required for skeletal muscle differentiation. Proceedings of the National Academy of Sciences of the United States of America. 99: 11025-30. PMID 12177420 DOI: 10.1073/pnas.162172899  0.68
2002 Cregan SP, Fortin A, MacLaurin JG, Callaghan SM, Cecconi F, Yu SW, Dawson TM, Dawson VL, Park DS, Kroemer G, Slack RS. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. The Journal of Cell Biology. 158: 507-17. PMID 12147675 DOI: 10.1083/jcb.200202130  0.68
2002 Ferguson KL, Vanderluit JL, Hébert JM, McIntosh WC, Tibbo E, MacLaurin JG, Park DS, Wallace VA, Vooijs M, McConnell SK, Slack RS. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. The Embo Journal. 21: 3337-46. PMID 12093735 DOI: 10.1093/emboj/cdf338  0.68
2002 Ghahremani MH, Keramaris E, Shree T, Xia Z, Davis RJ, Flavell R, Slack RS, Park DS. Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. The Journal of Biological Chemistry. 277: 35586-96. PMID 12091388 DOI: 10.1074/jbc.M204362200  0.68
2002 Maier JK, Lahoua Z, Gendron NH, Fetni R, Johnston A, Davoodi J, Rasper D, Roy S, Slack RS, Nicholson DW, MacKenzie AE. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2035-43. PMID 11896143  0.68
2002 Wang F, Corbett D, Osuga H, Osuga S, Ikeda JE, Slack RS, Hogan MJ, Hakim AM, Park DS. Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 171-82. PMID 11823715 DOI: 10.1097/00004647-200202000-00005  0.68
2001 Crocker SJ, Lamba WR, Smith PD, Callaghan SM, Slack RS, Anisman H, Park DS. c-Jun mediates axotomy-induced dopamine neuron death in vivo. Proceedings of the National Academy of Sciences of the United States of America. 98: 13385-90. PMID 11687617 DOI: 10.1073/pnas.231177098  0.68
2001 Fortin A, Cregan SP, MacLaurin JG, Kushwaha N, Hickman ES, Thompson CS, Hakim A, Albert PR, Cecconi F, Helin K, Park DS, Slack RS. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. The Journal of Cell Biology. 155: 207-16. PMID 11591730 DOI: 10.1083/jcb.200105137  0.68
2001 Simpson MT, MacLaurin JG, Xu D, Ferguson KL, Vanderluit JL, Davoli MA, Roy S, Nicholson DW, Robertson GS, Park DS, Slack RS. Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 7089-98. PMID 11549719  0.68
2001 Morris EJ, Keramaris E, Rideout HJ, Slack RS, Dyson NJ, Stefanis L, Park DS. Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5017-26. PMID 11438577  0.68
2001 Ferguson KL, Slack RS. The Rb pathway in neurogenesis. Neuroreport. 12: A55-62. PMID 11435948  0.68
2000 Osuga H, Osuga S, Wang F, Fetni R, Hogan MJ, Slack RS, Hakim AM, Ikeda JE, Park DS. Cyclin-dependent kinases as a therapeutic target for stroke. Proceedings of the National Academy of Sciences of the United States of America. 97: 10254-9. PMID 10944192 DOI: 10.1073/pnas.170144197  0.68
2000 Cregan SP, MacLaurin J, Gendron TF, Callaghan SM, Park DS, Parks RJ, Graham FL, Morley P, Slack RS. Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons. Gene Therapy. 7: 1200-9. PMID 10918488 DOI: 10.1038/sj.gt.3301208  0.68
2000 Ferguson KL, Callaghan SM, O'Hare MJ, Park DS, Slack RS. The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulation. The Journal of Biological Chemistry. 275: 33593-600. PMID 10915795 DOI: 10.1074/jbc.M004879200  0.68
2000 Hou ST, Callaghan D, Fournier MC, Hill I, Kang L, Massie B, Morley P, Murray C, Rasquinha I, Slack R, MacManus JP. The transcription factor E2F1 modulates apoptosis of neurons. Journal of Neurochemistry. 75: 91-100. PMID 10854251 DOI: 10.1046/j.1471-4159.2000.0750091.x  0.68
2000 O'Hare MJ, Hou ST, Morris EJ, Cregan SP, Xu Q, Slack RS, Park DS. Induction and modulation of cerebellar granule neuron death by E2F-1. The Journal of Biological Chemistry. 275: 25358-64. PMID 10851232 DOI: 10.1074/jbc.M001725200  0.68
2000 Keramaris E, Stefanis L, MacLaurin J, Harada N, Takaku K, Ishikawa T, Taketo MM, Robertson GS, Nicholson DW, Slack RS, Park DS. Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage. Molecular and Cellular Neurosciences. 15: 368-79. PMID 10845773 DOI: 10.1006/mcne.2000.0838  0.68
2000 Giovanni A, Keramaris E, Morris EJ, Hou ST, O'Hare M, Dyson N, Robertson GS, Slack RS, Park DS. E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3. The Journal of Biological Chemistry. 275: 11553-60. PMID 10766769 DOI: 10.1074/jbc.275.16.11553  0.68
1999 Cregan SP, MacLaurin JG, Craig CG, Robertson GS, Nicholson DW, Park DS, Slack RS. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7860-9. PMID 10479688  0.68
1999 Giovanni A, Wirtz-Brugger F, Keramaris E, Slack R, Park DS. Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death. The Journal of Biological Chemistry. 274: 19011-6. PMID 10383401 DOI: 10.1074/jbc.274.27.19011  0.68
1998 Gill RM, Slack R, Kiess M, Hamel PA. Regulation of expression and activity of distinct pRB, E2F, D-type cyclin, and CKI family members during terminal differentiation of P19 cells. Experimental Cell Research. 244: 157-70. PMID 9770359 DOI: 10.1006/excr.1998.4197  0.68
1996 Slack RS, Belliveau DJ, Rosenberg M, Atwal J, Lochmüller H, Aloyz R, Haghighi A, Lach B, Seth P, Cooper E, Miller FD. Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons. The Journal of Cell Biology. 135: 1085-96. PMID 8922388  0.68
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