Christopher W. Cowan, Ph.D. - Publications

Affiliations: 
McLean Hospital Harvard Medical School, Boston, MA, United States 

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Penrod RD, Kumar J, Smith LN, McCalley D, Nentwig T, Hughes B, Barry G, Glover K, Taniguchi M, Cowan CW. Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) regulates anxiety- and novelty-related behaviors. Genes, Brain, and Behavior. e12561. PMID 30761730 DOI: 10.1111/gbb.12561  0.76
2018 Anderson EM, Sun H, Guzman D, Taniguchi M, Cowan CW, Maze I, Nestler EJ, Self DW. Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30587852 DOI: 10.1038/s41386-018-0305-4  0.76
2018 Anderson EM, Penrod RD, Barry SM, Hughes BW, Taniguchi M, Cowan CW. It's a complex issue: Emerging connections between epigenetic regulators in drug addiction. The European Journal of Neuroscience. PMID 30251397 DOI: 10.1111/ejn.14170  0.76
2018 Penrod RD, Anderson EM, Cowan CW. Any Way You Splice It: New Molecular Mechanisms of Cocaine-Induced Alternative Gene Expression. Biological Psychiatry. PMID 29941147 DOI: 10.1016/j.biopsych.2018.06.004  0.76
2017 Li X, Carreria MB, Witonsky KR, Zeric T, Lofaro OM, Bossert JM, Zhang J, Surjono F, Richie CT, Harvey BK, Son H, Cowan CW, Nestler EJ, Shaham Y. Role of Dorsal Striatum Histone Deacetylase 5 in Incubation of Methamphetamine Craving. Biological Psychiatry. PMID 29397902 DOI: 10.1016/j.biopsych.2017.12.008  0.44
2017 Guzman D, Carreira MB, Friedman AK, Adachi M, Neve RL, Monteggia LM, Han MH, Cowan CW, Self DW. Inactivation of NMDA Receptors in the Ventral Tegmental Area During Cocaine Self-Administration Prevents GluA1 Up-Regulation but with Paradoxical Increases in Cocaine-Seeking Behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29196318 DOI: 10.1523/JNEUROSCI.2828-16.2017  0.44
2017 Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, ... ... Cowan CW, et al. HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. Neuron. 96: 130-144.e6. PMID 28957664 DOI: 10.1016/j.neuron.2017.09.015  0.76
2017 Anderson EM, Wissman AM, Chemplanikal J, Buzin N, Guzman D, Larson EB, Neve RL, Nestler EJ, Cowan CW, Self DW. BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors. Proceedings of the National Academy of Sciences of the United States of America. PMID 28808012 DOI: 10.1073/pnas.1702441114  0.76
2017 Penrod RD, Carreira MB, Taniguchi M, Kumar J, Maddox SA, Cowan CW. Novel role and regulation of HDAC4 in cocaine-related behaviors. Addiction Biology. PMID 28635037 DOI: 10.1111/adb.12522  0.76
2016 Smith LN, Penrod RD, Taniguchi M, Cowan CW. Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice. Journal of Visualized Experiments : Jove. PMID 26967472 DOI: 10.3791/53107  1
2015 Penrod RD, Wells AM, Carlezon WA, Cowan CW. Use of Adeno-Associated and Herpes Simplex Viral Vectors for In Vivo Neuronal Expression in Mice. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. 73: 4.37.1-4.37.31. PMID 26426386 DOI: 10.1002/0471142301.ns0437s73  0.76
2015 Robichaux MA, Chenaux G, Ho HH, Soskis MJ, Greenberg ME, Henkemeyer M, Cowan CW. EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure. Developmental Neurobiology. PMID 26148571 DOI: 10.1002/dneu.22323  0.76
2015 Robichaux MA, Chenaux G, Ho HYH, Soskis MJ, Greenberg ME, Henkemeyer M, Cowan CW. EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure Developmental Neurobiology. DOI: 10.1002/dneu.22323  1
2014 Smith LN, Jedynak JP, Fontenot MR, Hale CF, Dietz KC, Taniguchi M, Thomas FS, Zirlin BC, Birnbaum SG, Huber KM, Thomas MJ, Cowan CW. Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration. Neuron. 82: 645-58. PMID 24811383 DOI: 10.1016/j.neuron.2014.03.028  1
2014 Robichaux MA, Chenaux G, Ho HY, Soskis MJ, Dravis C, Kwan KY, Šestan N, Greenberg ME, Henkemeyer M, Cowan CW. EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding. Proceedings of the National Academy of Sciences of the United States of America. 111: 2188-93. PMID 24453220 DOI: 10.1073/pnas.1324215111  1
2014 Robichaux MA, Cowan CW. Signaling mechanisms of axon guidance and early synaptogenesis. Current Topics in Behavioral Neurosciences. 16: 19-48. PMID 24318963 DOI: 10.1007/7854_2013_255  1
2013 Smith LN, Cowan CW. Striking a balance in fragile X. Nature Medicine. 19: 1370-1. PMID 24202383 DOI: 10.1038/nm.3383  1
2013 Zang T, Maksimova MA, Cowan CW, Bassel-Duby R, Olson EN, Huber KM. Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Molecular and Cellular Neurosciences. 56: 39-49. PMID 23511190 DOI: 10.1016/j.mcn.2013.03.002  1
2013 Rothenfluh A, Cowan CW. Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin'? Current Opinion in Neurobiology. 23: 507-12. PMID 23428655 DOI: 10.1016/j.conb.2013.01.027  1
2013 Srivastava N, Robichaux MA, Chenaux G, Henkemeyer M, Cowan CW. EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak. Molecular and Cellular Neurosciences. 52: 106-16. PMID 23147113 DOI: 10.1016/j.mcn.2012.11.003  1
2012 Tsai NP, Wilkerson JR, Guo W, Maksimova MA, DeMartino GN, Cowan CW, Huber KM. Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 151: 1581-94. PMID 23260144 DOI: 10.1016/j.cell.2012.11.040  1
2012 Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nature Neuroscience. 15: 1645-54. PMID 23143520 DOI: 10.1038/nn.3249  0.76
2012 Wang Y, He H, Srivastava N, Vikarunnessa S, Chen YB, Jiang J, Cowan CW, Zhang X. Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization. Science Signaling. 5: ra6. PMID 22253263 DOI: 10.1126/scisignal.2002636  1
2012 Taniguchi M, Carreira MB, Smith LN, Zirlin BC, Neve RL, Cowan CW. Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron. 73: 108-20. PMID 22243750 DOI: 10.1016/j.neuron.2011.10.032  1
2012 Wang Y, He H, Srivastava N, Vikarunnessa S, Chen YB, Jiang J, Cowan CW, Zhang X. Plexins are gtpase-activating proteins for rap and are activated by induced dimerization (Science Signaling (2012) 5, (er2)) Science Signaling. 5. DOI: 10.1126/scisignal.5215er2  1
2011 Hale CF, Dietz KC, Varela JA, Wood CB, Zirlin BC, Leverich LS, Greene RW, Cowan CW. Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12426-36. PMID 21880903 DOI: 10.1523/JNEUROSCI.0685-11.2011  1
2010 Shen K, Cowan CW. Guidance molecules in synapse formation and plasticity. Cold Spring Harbor Perspectives in Biology. 2: a001842. PMID 20452946 DOI: 10.1101/cshperspect.a001842  1
2010 Pfeiffer BE, Zang T, Wilkerson JR, Taniguchi M, Maksimova MA, Smith LN, Cowan CW, Huber KM. Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron. 66: 191-7. PMID 20434996 DOI: 10.1016/j.neuron.2010.03.017  1
2008 Meyer DA, Richer E, Benkovic SA, Hayashi K, Kansy JW, Hale CF, Moy LY, Kim Y, O'Callaghan JP, Tsai LH, Greengard P, Nairn AC, Cowan CW, Miller DB, Antich P, et al. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proceedings of the National Academy of Sciences of the United States of America. 105: 18561-6. PMID 19017804 DOI: 10.1073/pnas.0806078105  1
2008 Cowan CW, Taniguchi M, Hale CF. Regulation of synaptic connectivity with chronic cocaine. The American Journal of Psychiatry. 165: 1393. PMID 18981071 DOI: 10.1176/appi.ajp.2008.08101465  1
2008 Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A, Russo SJ, Sikder D, Dewey CM, Davis MM, Greengard P, Nairn AC, Nestler EJ, Cowan CW. Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron. 59: 621-33. PMID 18760698 DOI: 10.1016/j.neuron.2008.06.020  1
2006 Hunter SG, Zhuang G, Brantley-Sieders D, Swat W, Cowan CW, Chen J. Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Molecular and Cellular Biology. 26: 4830-42. PMID 16782872 DOI: 10.1128/MCB.02215-05  1
2006 Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science (New York, N.Y.). 311: 1008-12. PMID 16484497 DOI: 10.1126/science.1122511  1
2005 Sturla LM, Cowan CW, Guenther L, Castellino RC, Kim JY, Pomeroy SL. A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death. Cancer Research. 65: 5683-9. PMID 15994942 DOI: 10.1158/0008-5472.CAN-04-2283  1
2005 Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 46: 205-17. PMID 15848800 DOI: 10.1016/j.neuron.2005.03.019  1
2005 Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, et al. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 46: 191-204. PMID 15848799 DOI: 10.1016/j.neuron.2005.01.030  1
2002 Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW, Dikkes P, Korsmeyer SJ, Greenberg ME. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Developmental Cell. 3: 631-43. PMID 12431371 DOI: 10.1016/S1534-5807(02)00326-X  1
2002 Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron. 34: 221-33. PMID 11970864 DOI: 10.1016/S0896-6273(02)00655-4  1
2001 He W, Melia TJ, Cowan CW, Wensel TG. Dependence of RGS9-1 membrane attachment on its C-terminal tail. The Journal of Biological Chemistry. 276: 48961-6. PMID 11677233 DOI: 10.1074/jbc.M107428200  1
2001 Griffith EC, Cowan CW, Greenberg ME. REST acts through multiple deacetylase complexes. Neuron. 31: 339-40. PMID 11516389 DOI: 10.1016/S0896-6273(01)00386-5  1
2001 Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. The Journal of Biological Chemistry. 276: 22287-95. PMID 11292825 DOI: 10.1074/jbc.M011539200  1
2001 Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature. 409: 1071-7. PMID 11234020 DOI: 10.1038/35059138  1
2001 Cowan CW, He W, Wensel TG. RGS proteins: lessons from the RGS9 subfamily. Progress in Nucleic Acid Research and Molecular Biology. 65: 341-59. PMID 11008492  1
2000 He F, Seryshev AB, Cowan CW, Wensel TG. Multiple zinc binding sites in retinal rod cGMP phosphodiesterase, PDE6alpha beta. The Journal of Biological Chemistry. 275: 20572-7. PMID 10787404 DOI: 10.1074/jbc.M000440200  1
2000 Cowan CW, Wensel TG, Arshavsky VY. Enzymology of GTPase acceleration in phototransduction. Methods in Enzymology. 315: 524-38. PMID 10736724  1
1999 Rahman Z, Gold SJ, Potenza MN, Cowan CW, Ni YG, He W, Wensel TG, Nestler EJ. Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2016-26. PMID 10066255  1
1998 Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proceedings of the National Academy of Sciences of the United States of America. 95: 5351-6. PMID 9560279 DOI: 10.1073/pnas.95.9.5351  1
1998 He W, Cowan CW, Wensel TG. RGS9, a GTPase accelerator for phototransduction. Neuron. 20: 95-102. PMID 9459445 DOI: 10.1016/S0896-6273(00)80437-7  1
1997 Melia TJ, Cowan CW, Angleson JK, Wensel TG. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin. Biophysical Journal. 73: 3182-91. PMID 9414230 DOI: 10.1016/S0006-3495(97)78344-9  1
1997 He W, Cowan CW, Wense TG. Retinal-specific expression of rgs9, a gap for heterotrimeric g proteins Investigative Ophthalmology and Visual Science. 38: S477.  1
1996 Cowan CW, Angleson JK, Wensel TG. Solubilization and partial purification of Gtα-GAP from rod outer segment membranes Investigative Ophthalmology and Visual Science. 37: S809.  1
1996 Wensel TG, Seryshev A, Cowan CW. Zinc and retinal cGMP phosphodiesterase Investigative Ophthalmology and Visual Science. 37: S239.  1
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