Göran Klement - Related publications

Affiliations: 
AstraZeneca LP, Canóvanas, Canóvanas, Puerto Rico 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Hasan S, Megaro A, Cenciarini M, Coretti L, Botti FM, Imbrici P, Steinbusch HWM, Hunter T, Hunter G, Pessia M, D'Adamo MC. Electromechanical coupling of the Kv1.1 voltage-gated K channel is fine-tuned by the simplest amino acid residue in the S4-S5 linker. Pflugers Archiv : European Journal of Physiology. PMID 32577860 DOI: 10.1007/s00424-020-02414-0   
2020 Guan W, Stephens RF, Mourad O, Mehta A, Fux J, Spafford JD. Unique cysteine-enriched, D2L5 and D4L6 extracellular loops in Ca3 T-type channels alter the passage and block of monovalent and divalent ions. Scientific Reports. 10: 12404. PMID 32710088 DOI: 10.1038/s41598-020-69197-3   
2020 Cai S, Tuohy P, Ma C, Kitamura N, Gomez K, Zhou Y, Ran D, Bellampalli SS, Yu J, Luo S, Dorame A, Ngan Pham NY, Molnar G, Streicher JM, Patek M, et al. A modulator of the low-voltage activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies. Pain. PMID 32541387 DOI: 10.1097/j.pain.0000000000001955   
2020 Montandon GG, Cassoli JS, Peigneur S, Braga TV, Moreira Dos Santos D, Bittencourt Paiva AL, Ricardo de Moraes É, Kushmerick C, Borges MH, Richardson M, Monteiro de Castro Pimenta A, Kjeldsen F, Vasconcelos Diniz MR, Tytgat J, Elena de Lima M. GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels. Biochimie. PMID 32717411 DOI: 10.1016/j.biochi.2020.07.008   
2020 Montandon GG, Cassoli JS, Peigneur S, Braga TV, Moreira Dos Santos D, Bittencourt Paiva AL, Ricardo de Moraes É, Kushmerick C, Borges MH, Richardson M, Monteiro de Castro Pimenta A, Kjeldsen F, Vasconcelos Diniz MR, Tytgat J, Elena de Lima M. GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels. Biochimie. PMID 32717411 DOI: 10.1016/j.biochi.2020.07.008   
2020 Montandon GG, Cassoli JS, Peigneur S, Braga TV, Moreira Dos Santos D, Bittencourt Paiva AL, Ricardo de Moraes É, Kushmerick C, Borges MH, Richardson M, Monteiro de Castro Pimenta A, Kjeldsen F, Vasconcelos Diniz MR, Tytgat J, Elena de Lima M. GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels. Biochimie. PMID 32717411 DOI: 10.1016/j.biochi.2020.07.008   
2020 Thapak P, Vaidya B, Joshi HC, Singh JN, Sharma SS. Therapeutic Potential of Pharmacological Agents Targeting TRP Channels in CNS Disorders. Pharmacological Research. 105026. PMID 32562815 DOI: 10.1016/j.phrs.2020.105026   
2020 Chen X, Bründl M, Friesacher T, Stary-Weinzinger A. Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K Channel. Frontiers in Pharmacology. 11: 721. PMID 32499707 DOI: 10.3389/fphar.2020.00721   
2020 Fletcher-Taylor S, Thapa P, Sepela RJ, Kaakati R, Yarov-Yarovoy V, Sack JT, Cohen BE. Distinguishing Potassium Channel Resting State Conformations in Live Cells with Environment-Sensitive Fluorescence. Acs Chemical Neuroscience. PMID 32579336 DOI: 10.1021/acschemneuro.0c00276   
2020 Yang W, Wang Y, Guo J, He L, Zhou Y, Zheng H, Liu Z, Zhu P, Zhang XC. Cryo-EM structure of CLHM1 ion channel from Caenorhabditis elegans. Protein Science : a Publication of the Protein Society. PMID 32557855 DOI: 10.1002/pro.3904   
2020 Van Theemsche KM, Van de Sande DV, Snyders DJ, Labro AJ. Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K and Na Channels. Frontiers in Pharmacology. 11: 735. PMID 32499709 DOI: 10.3389/fphar.2020.00735   
2020 Guet-McCreight A, Skinner FK. Computationally going where experiments cannot: a dynamical assessment of dendritic ion channel currents during -like states. F1000research. 9: 180. PMID 32595950 DOI: 10.12688/f1000research.22584.2   
2020 Zhu W, Li T, Silva JR, Chen J. Conservation and divergence in NaChBac and Na1.7 pharmacology reveals novel drug interaction mechanisms. Scientific Reports. 10: 10730. PMID 32612253 DOI: 10.1038/s41598-020-67761-5   
2020 Ozekin YH, Isner T, Bates EA. Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development. Frontiers in Molecular Neuroscience. 13: 99. PMID 32581710 DOI: 10.3389/fnmol.2020.00099   
2020 Cardoso FC. Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. Biochemical Pharmacology. 114107. PMID 32579958 DOI: 10.1016/j.bcp.2020.114107   
2020 Zhou X, Xu Y, Wang G, Jia Y. Ionic channel blockage in stochastic Hodgkin-Huxley neuronal model driven by multiple oscillatory signals. Cognitive Neurodynamics. 14: 569-578. PMID 32655717 DOI: 10.1007/s11571-020-09593-7   
2020 Zhao Y, Ung PM, Zahoránszky-Kőhalmi G, Zakharov AV, Martinez NJ, Simeonov A, Glaaser IW, Rai G, Schlessinger A, Marugan JJ, Slesinger PA. Identification of a G-Protein-Independent Activator of GIRK Channels. Cell Reports. 31: 107770. PMID 32553165 DOI: 10.1016/j.celrep.2020.107770   
2020 Wang S, Cortes CJ. Interactions with PDZ proteins diversify voltage-gated calcium channel signaling. Journal of Neuroscience Research. PMID 32476168 DOI: 10.1002/jnr.24650   
2020 Pai VP, Cervera J, Mafe S, Willocq V, Lederer EK, Levin M. HCN2 Channel-Induced Rescue of Brain Teratogenesis Local and Long-Range Bioelectric Repair. Frontiers in Cellular Neuroscience. 14: 136. PMID 32528251 DOI: 10.3389/fncel.2020.00136   
2020 Liu N, Wu J, Chen Y, Zhao J. Channels that Cooperate with TRPV4 in the Brain. Journal of Molecular Neuroscience : Mn. PMID 32524421 DOI: 10.1007/s12031-020-01574-z   
2020 Burton MJ, Cresser-Brown J, Thomas M, Portolano N, Basran J, Freeman SL, Kwon H, Bottrill AR, Llansola-Portoles MJ, Pascal AA, Jukes-Jones R, Chernova T, Schmid R, Davies NW, Storey NM, et al. Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel. The Journal of Biological Chemistry. PMID 32723862 DOI: 10.1074/jbc.RA120.014150   
2020 Vickstrom CR, Liu X, Zhang Y, Mu L, Kelly TJ, Yan X, Hu MM, Snarrenberg ST, Liu QS. T-type calcium channels contribute to burst firing in a subpopulation of medial habenula neurons. Eneuro. PMID 32719103 DOI: 10.1523/ENEURO.0201-20.2020   
2020 Deng Z, Maksaev G, Schlegel AM, Zhang J, Rau M, Fitzpatrick JAJ, Haswell ES, Yuan P. Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance. Nature Communications. 11: 3690. PMID 32704140 DOI: 10.1038/s41467-020-17538-1   
2020 Morán-Zendejas R, Delgado-Ramírez M, Xu J, Valdés-Abadía B, Aréchiga-Figueroa IA, Cui M, Rodríguez-Menchaca AA. In vitro and in silico characterization of the inhibition of Kir4.1 channels by aminoglycoside antibiotics. British Journal of Pharmacology. PMID 32726456 DOI: 10.1111/bph.15214   
2020 Kim DH, Park WH, Oh HG, Jeon DC, Lim JM, Song KS. Two-Channel Graphene pH Sensor Using Semi-Ionic Fluorinated Graphene Reference Electrode. Sensors (Basel, Switzerland). 20. PMID 32731474 DOI: 10.3390/s20154184   
2020 Shi J, Wang H, Shi S, Yuan G, Jia Q, Shi S, Zhang X, Hu Y. Bibliometric analysis of calcium channel research (2010-2019). Channels (Austin, Tex.). 14: 193-202. PMID 32654583 DOI: 10.1080/19336950.2020.1788903   
2020 van der Horst J, Greenwood IA, Jepps TA. Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels. Frontiers in Physiology. 11: 727. PMID 32695022 DOI: 10.3389/fphys.2020.00727   
2020 Kwon Y, Haam CE, Byeon S, Choi SJ, Shin DH, Choi SK, Lee YH. Vasodilatory Effect of Extract in Rat Mesenteric Arteries. Molecules (Basel, Switzerland). 25. PMID 32664327 DOI: 10.3390/molecules25143160   
2020 Salvage SC, Huang CL, Jackson AP. Cell-Adhesion Properties of β-Subunits in the Regulation of Cardiomyocyte Sodium Channels. Biomolecules. 10. PMID 32630316 DOI: 10.3390/biom10070989   
2020 Weiss N, Zamponi GW. Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels. Cellular and Molecular Neurobiology. PMID 32514826 DOI: 10.1007/s10571-020-00894-3   
2020 Neumaier F, Alpdogan S, Hescheler J, Schneider T. Zn2+-induced changes in Cav2.3 channel function: An electrophysiological and modeling study. The Journal of General Physiology. 152. PMID 32559275 DOI: 10.1085/jgp.202012585   
2020 Li J, Maghera J, Lamothe SM, Marco EJ, Kurata HT. Heteromeric assembly of truncated neuronal Kv7 channels: implications for neurological disease and pharmacotherapy. Molecular Pharmacology. PMID 32580997 DOI: 10.1124/mol.120.119644   
2020 Zhang Q, Dou H, Rorsman P. 'Resistance is futile?' - paradoxical inhibitory effects of K channel closure in glucagon-secreting α-cells. The Journal of Physiology. PMID 32716554 DOI: 10.1113/JP279775   
2020 Thompson E, Eldstrom J, Fedida D. Hormonal Signaling Actions on Kv7.1 (KCNQ1) Channels. Annual Review of Pharmacology and Toxicology. PMID 32667860 DOI: 10.1146/annurev-pharmtox-010919-023645   
2020 Absalom NL, Liao VW, Chebib M. Ligand-gated ion channels in genetic disorders and the question of efficacy. The International Journal of Biochemistry & Cell Biology. 105806. PMID 32679079 DOI: 10.1016/j.biocel.2020.105806   
2020 Janicki Ł, Li H, Keller S, Mishra UK, Kudrawiec R. SiN/(Al,Ga)N interface barrier in N-polar III-nitride transistor structures studied by modulation spectroscopy. Scientific Reports. 10: 12099. PMID 32694529 DOI: 10.1038/s41598-020-68963-7   
2020 Tiwari SK, Bhat S, Mahato KK. Design and Fabrication of Low-cost Microfluidic Channel for Biomedical Application. Scientific Reports. 10: 9215. PMID 32514070 DOI: 10.1038/s41598-020-65995-x   
2020 Wadsworth PA, Singh AK, Nguyen N, Dvorak NM, Tapia CM, Russell WK, Stephan C, Laezza F. JAK2 regulates Nav1.6 channel function via FGF14 phosphorylation. Biochimica Et Biophysica Acta. Molecular Cell Research. 118786. PMID 32599005 DOI: 10.1016/j.bbamcr.2020.118786   
2020 Zamani M, Budde T, Bozorgi H. Intracerebroventricular administration of N-type calcium channel blocker ziconotide displays anticonvulsant, anxiolytic, and sedative effects in rats: A preclinical and pilot study. Epilepsy & Behavior : E&B. 111: 107251. PMID 32593873 DOI: 10.1016/j.yebeh.2020.107251   
2020 Sherikar AS, Bhatia MS, Dhavale RP. Identification and Investigation of Chalcone Derivatives as Calcium Channel Blockers: Pharmacophore modeling, Docking studies, In-vitro screening, and 3D-QSAR Analysis. Current Computer-Aided Drug Design. PMID 32664842 DOI: 10.2174/1573409916666200714143930   
2020 Lee SE, Kim DH, Son SM, Choi SY, You RY, Kim CH, Choi W, Kim HS, Lim YJ, Han JY, Kim HW, Yang IJ, Xu WX, Lee SJ, Kim YC, et al. Physiological function and molecular composition of ATP-sensitive K channels in human gastric smooth muscle. Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi. 56: 29-45. PMID 32581184 DOI: 10.1540/jsmr.56.29   
2020 Liu Y, Mikrani R, He Y, Faran Asraf Baig MM, Abbas M, Naveed M, Tang M, Zhang Q, Li C, Zhou X. TRPM8 channels: A review of distribution and clinical role. European Journal of Pharmacology. 173312. PMID 32610057 DOI: 10.1016/j.ejphar.2020.173312   
2020 Liu N, Yan F, Ma Q, Zhao J. Modulation of TRPV4 and BKCa for treatment of brain diseases. Bioorganic & Medicinal Chemistry. 28: 115609. PMID 32690264 DOI: 10.1016/j.bmc.2020.115609   
2020 Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A. Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and β4-peptide on human cardiac Nav1.5 sodium channel gating properties. Data in Brief. 31: 105844. PMID 32637473 DOI: 10.1016/j.dib.2020.105844   
2020 Clatot J, Neyroud N, Cox R, Souil C, Huang J, Guicheney P, Antzelevitch C. Inter-Regulation of K4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies. International Journal of Molecular Sciences. 21. PMID 32709127 DOI: 10.3390/ijms21145057   
2020 Nguyen HM, di Lucente J, Chen YJ, Cui Y, Ibrahim RH, Pennington MW, Jin LW, Maezawa I, Wulff H. Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia. Glia. PMID 32525239 DOI: 10.1002/glia.23847   
2020 Thorington GU, Hessinger DA. Activated L-Type Calcium Channels Inhibit Chemosensitized Nematocyst Discharge from Sea Anemone Tentacles. The Biological Bulletin. 238: 180-192. PMID 32597714 DOI: 10.1086/708947   
2020 Peters CH, Watkins AR, Poirier OL, Ruben PC. E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms. The Journal of General Physiology. 152. PMID 32569350 DOI: 10.1085/jgp.202012595   
2020 Xing YL, Sun H, Feng GH, Shen FR, Zhao J. Artificial Evolution Network: A Computational Perspective on the Expansibility of the Nervous System. Ieee Transactions On Neural Networks and Learning Systems. PMID 32584773 DOI: 10.1109/TNNLS.2020.3002556   
2020 Gigolaev AM, Kuzmenkov AI, Peigneur S, Tabakmakher VM, Pinheiro-Junior EL, Chugunov AO, Efremov RG, Tytgat J, Vassilevski AA. Tuning Scorpion Toxin Selectivity: Switching From K1.1 to K1.3. Frontiers in Pharmacology. 11: 1010. PMID 32733247 DOI: 10.3389/fphar.2020.01010