Kristoffer Sahlholm - Publications

Affiliations: 
Karolinska Institute, Stockholm, Sweden 

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Stepniewski TM, Mancini A, Ågren R, Torrens-Fontanals M, Semache M, Bouvier M, Sahlholm K, Breton B, Selent J. Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome. Chemical Science. 12: 10990-11003. PMID 34522296 DOI: 10.1039/d1sc00749a  1
2021 López-Cano M, Font J, Aso E, Sahlholm K, Cabré G, Giraldo J, De Koninck Y, Hernando J, Llebaria A, Fernández-Dueñas V, Ciruela F. Remote local photoactivation of morphine produces analgesia without opioid-related adverse effects. British Journal of Pharmacology. PMID 34363210 DOI: 10.1111/bph.15645  1
2021 Betari N, Teigen K, Sahlholm K, Haavik J. Synthetic corticosteroids as tryptophan hydroxylase stabilizers. Future Medicinal Chemistry. PMID 34251270 DOI: 10.4155/fmc-2021-0068  1
2021 Ågren R, Stepniewski TM, Zeberg H, Selent J, Sahlholm K. Dopamine D Receptor Agonist Binding Kinetics-Role of a Conserved Serine Residue. International Journal of Molecular Sciences. 22. PMID 33920848 DOI: 10.3390/ijms22084078  1
2021 Hsieh CJ, Riad A, Lee JY, Sahlholm K, Xu K, Luedtke RR, Mach RH. Interaction of Ligands for PET with the Dopamine D3 Receptor: In Silico and In Vitro Methods. Biomolecules. 11. PMID 33918451 DOI: 10.3390/biom11040529  1
2021 Paucar M, Ågren R, Li T, Lissmats S, Bergendal Å, Weinberg J, Nilsson D, Savichetva I, Sahlholm K, Nilsson J, Svenningsson P. V374A KCND3 Pathogenic Variant Associated With Paroxysmal Ataxia Exacerbations. Neurology. Genetics. 7: e546. PMID 33575485 DOI: 10.1212/NXG.0000000000000546  1
2020 Betari N, Sahlholm K, Morató X, Godoy-Marín H, Jáuregui O, Teigen K, Ciruela F, Haavik J. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- and Investigations. Frontiers in Pharmacology. 11: 593416. PMID 33324221 DOI: 10.3389/fphar.2020.593416  1
2020 Ågren R, Sahlholm K. Voltage-Dependent Dopamine Potency at D-Like Dopamine Receptors. Frontiers in Pharmacology. 11: 581151. PMID 33117177 DOI: 10.3389/fphar.2020.581151  1
2020 Valle-León M, Callado LF, Aso E, Cajiao-Manrique MM, Sahlholm K, López-Cano M, Soler C, Altafaj X, Watanabe M, Ferré S, Fernández-Dueñas V, Menchón JM, Ciruela F. Decreased striatal adenosine A-dopamine D receptor heteromerization in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 33010795 DOI: 10.1038/s41386-020-00872-9  1
2020 Ågren R, Zeberg H, Maciej Stępniewski T, Free RB, Reilly SW, Luedtke RR, Århem P, Ciruela F, Sibley DR, Mach RH, Selent J, Nilsson J, Sahlholm K. A ligand with two modes of interaction with the dopamine D2 receptor - An induced-fit mechanism of insurmountable antagonism. Acs Chemical Neuroscience. PMID 32865974 DOI: 10.1021/Acschemneuro.0C00477  1
2020 Betari N, Sahlholm K, Ishizuka Y, Teigen K, Haavik J. Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis. Future Medicinal Chemistry. PMID 32752885 DOI: 10.4155/fmc-2020-0127  1
2020 Zeberg H, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, Hevers W, Robinson HPC, Kelso J, Pääbo S. A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans. Current Biology : Cb. PMID 32707058 DOI: 10.1016/J.Cub.2020.06.045  1
2019 Reilly SW, Riad AA, Hsieh CJ, Sahlholm K, Jacome DA, Griffin S, Taylor M, Weng CC, Xu K, Kirschner N, Luedtke RR, Parry C, Malhotra S, Karanicolas J, Mach RH. Leveraging a Low Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity Across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs). Journal of Medicinal Chemistry. PMID 31021617 DOI: 10.1021/Acs.Jmedchem.9B00412  1
2018 Sahlholm K, Valle-León M, Fernández-Dueñas V, Ciruela F. Dopamine receptor heteromers: biasing antipsychotics. Future Medicinal Chemistry. PMID 30518245 DOI: 10.4155/Fmc-2018-0335  1
2018 Zeberg H, Sahlholm K. Antipsychotics with similar association kinetics at dopamine D receptors differ in extrapyramidal side-effects. Nature Communications. 9: 3577. PMID 30177830 DOI: 10.1038/S41467-018-04489-X  1
2018 Ågren R, Århem P, Nilsson J, Sahlholm K. The beta-arrestin-biased dopamine D2 receptor ligand, UNC9994, is a partial agonist at G-protein-mediated potassium channel activation. The International Journal of Neuropsychopharmacology. PMID 29986044 DOI: 10.1093/Ijnp/Pyy059  1
2018 Sahlholm K, Valle-Leon M, Taura J, Fernandez-Duenas V, Ciruela F. Effects of the Dopamine Stabilizer, Pridopidine, on Basal and Phencyclidine-Induced Locomotion: Role of Dopamine D2 and Sigma-1 Receptors. Cns & Neurological Disorders Drug Targets. PMID 29952269 DOI: 10.2174/1871527317666180627103337  1
2018 Sahlholm K, Valle-León M, Fernández-Dueñas V, Ciruela F. Pridopidine Reverses Phencyclidine-Induced Memory Impairment. Frontiers in Pharmacology. 9: 338. PMID 29692729 DOI: 10.3389/Fphar.2018.00338  1
2018 Ågren R, Sahlholm K, Nilsson J, Århem P. Point mutation of a conserved aspartate, D69, in the muscarinic M2 receptor does not modify voltage-sensitive agonist potency. Biochemical and Biophysical Research Communications. PMID 29305262 DOI: 10.1016/J.Bbrc.2018.01.005  1
2017 Reilly SW, Griffin S, Taylor M, Sahlholm K, Weng CC, Xu K, Jacome DA, Luedtke RR, Mach RH. Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores. Journal of Medicinal Chemistry. PMID 29125762 DOI: 10.1021/Acs.Jmedchem.7B01248  1
2017 Taura J, Valle-León M, Sahlholm K, Watanabe M, Van Craenenbroeck K, Fernández-Dueñas V, Ferré S, Ciruela F. Behavioral control by striatal A2A -dopamine D2 receptor heteromers. Genes, Brain, and Behavior. PMID 29053217 DOI: 10.1111/Gbb.12432  1
2017 Sahlholm K, Gómez-Soler M, Valle-León M, López-Cano M, Taura JJ, Ciruela F, Fernández-Dueñas V. Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression. Molecular Neurobiology. PMID 28779351 DOI: 10.1007/S12035-017-0696-Y  1
2017 Sahlholm K, Ielacqua GD, Xu J, Jones LA, Schlegel F, Mach RH, Rudin M, Schroeter A. The role of beta-arrestin2 in shaping fMRI BOLD responses to dopaminergic stimulation. Psychopharmacology. PMID 28382543 DOI: 10.1007/S00213-017-4609-6  1
2016 Sahlholm K, Zeberg H, Nilsson J, Ögren SO, Fuxe K, Århem P. The fast-off hypothesis revisited: A functional kinetic study of antipsychotic antagonism of the dopamine D2 receptor. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 26811292 DOI: 10.1016/J.Euroneuro.2016.01.001  1
2015 Soto-Cerrato V, Manuel-Manresa P, Hernando E, Calabuig-Fariñas S, Martinez-Romero A, Fernandez Dueñas V, Sahlholm K, Knopfel T, Garcia-Valverde M, Rodilla AM, Jantus-Lewintre E, Farras R, Ciruela F, Perez-Tomas R, Quesada R. Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane that Triggers Differentiation and Cell Death in Cancer Stem Cells. Journal of the American Chemical Society. PMID 26632983 DOI: 10.1021/Jacs.5B09970  1
2015 Lyu C, Mulder J, Barde S, Sahlholm K, Zeberg H, Nilsson J, Århem P, Hökfelt T, Fried K, Shi TJ. G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy. Molecular Pain. 11: 44. PMID 26199148 DOI: 10.1186/S12990-015-0044-Z  1
2015 Sahlholm K, Sijbesma JW, Maas B, Kwizera C, Marcellino D, Ramakrishnan NK, Dierckx RA, Elsinga PH, van Waarde A. Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses. Psychopharmacology. 232: 3443-53. PMID 26159455 DOI: 10.1007/S00213-015-3997-8  1
2015 Sahlholm K, Liao F, Holtzman DM, Xu J, Mach RH. Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice. Biochemical and Biophysical Research Communications. 460: 439-45. PMID 25796326 DOI: 10.1016/J.Bbrc.2015.03.052  1
2014 Sahlholm K, Marcellino D, Nilsson J, Ögren SO, Fuxe K, Ã…rhem P. Typical and atypical antipsychotics do not differ markedly in their reversibility of antagonism of the dopamine D2 receptor. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 149-55. PMID 24074141 DOI: 10.1017/S1461145713000801  1
2013 Sahlholm K, Ã…rhem P, Fuxe K, Marcellino D. The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor. Molecular Psychiatry. 18: 12-4. PMID 22349783 DOI: 10.1038/Mp.2012.3  1
2012 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. Voltage sensitivities and deactivation kinetics of histamine H₃ and Hâ‚„ receptors. Biochimica Et Biophysica Acta. 1818: 3081-9. PMID 22885137 DOI: 10.1016/J.Bbamem.2012.07.027  1
2011 Sahlholm K. The role of RGS protein in agonist-dependent relaxation of GIRK currents in Xenopus oocytes. Biochemical and Biophysical Research Communications. 415: 509-14. PMID 22068057 DOI: 10.1016/J.Bbrc.2011.10.106  1
2011 Sahlholm K, Barchad-Avitzur O, Marcellino D, Gómez-Soler M, Fuxe K, Ciruela F, Arhem P. Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands. Neuropharmacology. 61: 937-49. PMID 21752340 DOI: 10.1016/J.Neuropharm.2011.06.022  1
2010 Ciruela F, Fernández-Dueñas V, Sahlholm K, Fernández-Alacid L, Nicolau JC, Watanabe M, Luján R. Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits. The European Journal of Neuroscience. 32: 1265-77. PMID 20846323 DOI: 10.1111/J.1460-9568.2010.07356.X  1
2010 Marcellino D, Navarro G, Sahlholm K, Nilsson J, Agnati LF, Canela EI, Lluís C, Ã…rhem P, Franco R, Fuxe K. Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer. Biochemical and Biophysical Research Communications. 394: 988-92. PMID 20307491 DOI: 10.1016/J.Bbrc.2010.03.104  1
2009 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Århem P. Differential Voltage-sensitivities Of Agonists At The Dopamine D2S Receptor Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.1986  1
2008 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Arhem P. Voltage-sensitivity at the human dopamine D2S receptor is agonist-specific. Biochemical and Biophysical Research Communications. 377: 1216-21. PMID 18983826 DOI: 10.1016/J.Bbrc.2008.10.117  1
2008 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Arhem P. Differential voltage-sensitivity of D2-like dopamine receptors. Biochemical and Biophysical Research Communications. 374: 496-501. PMID 18652803 DOI: 10.1016/J.Bbrc.2008.07.052  1
2008 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. Electrophysiology-based analysis of human histamine H(4) receptor pharmacology using GIRK channel coupling in Xenopus oocytes. European Journal of Pharmacology. 591: 52-8. PMID 18582456 DOI: 10.1016/J.Ejphar.2008.06.029  1
2008 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. Voltage-dependence of the human dopamine D2 receptor. Synapse (New York, N.Y.). 62: 476-80. PMID 18361445 DOI: 10.1002/Syn.20509  1
2008 Århem P, Sahlholm K, Nilsson J. Mechanisms of Anaesthesia: A Role for Voltage-Gated K Channels? Anaesthesia Science. 117-127. DOI: 10.1002/9780470755297.ch9  1
2007 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes. European Journal of Pharmacology. 567: 206-10. PMID 17537431 DOI: 10.1016/J.Ejphar.2007.04.032  1
2007 Lönn E, Sahlholm K, Maimaiti R, Abdukarim K, Andersson R. A traditional society in change encounters HIV/AIDS: knowledge, attitudes, and risk behavior among students in northwestern China. Aids Patient Care and Stds. 21: 48-56. PMID 17263657 DOI: 10.1089/apc.2006.0063  1
2005 Persson AS, Klement G, Almgren M, Sahlholm K, Nilsson J, Petersson S, Arhem P, Schalling M, Lavebratt C. A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interaction. Bmc Neuroscience. 6: 65. PMID 16305740 DOI: 10.1186/1471-2202-6-65  1
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