Paul Marshall Mathews - Publications

Psychiatry New York University School of Medicine, New York, NY, United States 
Alzheimer's disease, APP metabolism, endocytosis

90 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mathews PM, Levy E. Exosome Production Is Key to Neuronal Endosomal Pathway Integrity in Neurodegenerative Diseases. Frontiers in Neuroscience. 13: 1347. PMID 31911768 DOI: 10.3389/fnins.2019.01347  0.52
2018 Peng KY, Pérez-González R, Alldred MJ, Goulbourne CN, Morales-Corraliza J, Saito M, Saito M, Ginsberg SD, Mathews PM, Levy E. Apolipoprotein E4 genotype compromises brain exosome production. Brain : a Journal of Neurology. PMID 30496349 DOI: 10.1093/brain/awy289  0.52
2018 East BS, Fleming G, Peng K, Olofsson JK, Levy E, Mathews PM, Wilson DA. Human apolipoprotein E genotype differentially affects olfactory behavior and sensory physiology in mice. Neuroscience. PMID 29678753 DOI: 10.1016/j.neuroscience.2018.04.009  0.52
2017 Nuriel T, Peng KY, Ashok A, Dillman AA, Figueroa HY, Apuzzo J, Ambat J, Levy E, Cookson MR, Mathews PM, Duff KE. The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo. Frontiers in Neuroscience. 11: 702. PMID 29311783 DOI: 10.3389/fnins.2017.00702  0.52
2017 Cabrera E, Mathews P, Mezhericher E, Beach TG, Deng J, Neubert TA, Rostagno A, Ghiso J. Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition. Biochimica Et Biophysica Acta. PMID 28711595 DOI: 10.1016/j.bbadis.2017.07.005  0.36
2016 Peng KY, Mathews PM, Levy E, Wilson DA. Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments. Neuroscience. PMID 28003161 DOI: 10.1016/j.neuroscience.2016.12.004  0.52
2016 Mathews PM, Levy E. Cystatin C in aging and in Alzheimer's disease. Ageing Research Reviews. PMID 27333827 DOI: 10.1016/j.arr.2016.06.003  0.52
2016 Morales-Corraliza J, Wong H, Mazzella MJ, Che S, Lee SH, Petkova E, Wagner JD, Hemby SE, Ginsberg SD, Mathews PM. Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 4248-58. PMID 27076423 DOI: 10.1523/JNEUROSCI.4640-14.2016  1
2016 Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiology of Aging. 39: 90-98. PMID 26923405 DOI: 10.1016/j.neurobiolaging.2015.11.013  1
2015 Mahler J, Morales-Corraliza J, Stolz J, Skodras A, Radde R, Duma CC, Eisele YS, Mazzella MJ, Wong H, Klunk WE, Nilsson KP, Staufenbiel M, Mathews PM, Jucker M, Wegenast-Braun BM. Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice. Neurobiology of Aging. 36: 2241-7. PMID 25911278 DOI: 10.1016/j.neurobiolaging.2015.03.011  1
2015 Schafer MJ, Alldred MJ, Lee SH, Calhoun ME, Petkova E, Mathews PM, Ginsberg SD. Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice. Neurobiology of Aging. 36: 1293-302. PMID 25556162 DOI: 10.1016/j.neurobiolaging.2014.10.043  1
2015 Duffy AM, Morales-Corraliza J, Bermudez-Hernandez KM, Schaner MJ, Magagna-Poveda A, Mathews PM, Scharfman HE. Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age. Neurobiology of Aging. 36: 134-48. PMID 25109765 DOI: 10.1016/j.neurobiolaging.2014.07.001  1
2013 Jeon AH, Böhm C, Chen F, Huo H, Ruan X, Ren CH, Ho K, Qamar S, Mathews PM, Fraser PE, Mount HT, St George-Hyslop P, Schmitt-Ulms G. Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. The Journal of Biological Chemistry. 288: 15352-66. PMID 23589300 DOI: 10.1074/jbc.M112.441840  1
2013 Choi JH, Kaur G, Mazzella MJ, Morales-Corraliza J, Levy E, Mathews PM. Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice. Journal of Alzheimer's Disease : Jad. 34: 691-700. PMID 23254640 DOI: 10.3233/JAD-122143  1
2013 Wesson DW, Morales-Corraliza J, Mazzella MJ, Wilson DA, Mathews PM. Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model. Behavioural Brain Research. 237: 96-102. PMID 23000537 DOI: 10.1016/j.bbr.2012.09.019  1
2013 Papon MA, El Khoury NB, Marcouiller F, Julien C, Morin F, Bretteville A, Petry FR, Gaudreau S, Amrani A, Mathews PM, Hébert SS, Planel E. Deregulation of protein phosphatase 2A and hyperphosphorylation of Ï„ protein following onset of diabetes in NOD mice. Diabetes. 62: 609-17. PMID 22961084 DOI: 10.2337/db12-0187  1
2013 Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM. Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiology of Aging. 34: 137-45. PMID 22608241 DOI: 10.1016/j.neurobiolaging.2012.04.007  1
2012 Schmidt SD, Mazzella MJ, Nixon RA, Mathews PM. Aβ measurement by enzyme-linked immunosorbent assay. Methods in Molecular Biology (Clifton, N.J.). 849: 507-27. PMID 22528112 DOI: 10.1007/978-1-61779-551-0_34  1
2012 Schmidt SD, Nixon RA, Mathews PM. Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ. Methods in Molecular Biology (Clifton, N.J.). 849: 493-506. PMID 22528111 DOI: 10.1007/978-1-61779-551-0_33  1
2012 Dumanis SB, Chamberlain KA, Jin Sohn Y, Jin Lee Y, Guénette SY, Suzuki T, Mathews PM, Pak DTs, Rebeck GW, Suh YH, Park HS, Hoe HS. FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Molecular Neurodegeneration. 7: 9. PMID 22429478 DOI: 10.1186/1750-1326-7-9  1
2012 Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA, Mathews PM. Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiology of Aging. 33: 1125.e9-18. PMID 22206846 DOI: 10.1016/j.neurobiolaging.2011.11.023  1
2011 Restituito S, Khatri L, Ninan I, Mathews PM, Liu X, Weinberg RJ, Ziff EB. Synaptic autoregulation by metalloproteases and γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12083-93. PMID 21865451 DOI: 10.1523/JNEUROSCI.2513-11.2011  1
2011 Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Mathews PM, et al. Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy. 7: 788-9. PMID 21464620 DOI: 10.4161/auto.7.7.15596  1
2011 Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, Mathews PM, Saftig P, Sandhoff K, Walter J. Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1837-49. PMID 21289194 DOI: 10.1523/JNEUROSCI.2954-10.2011  1
2011 Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Mathews PM, et al. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain : a Journal of Neurology. 134: 258-77. PMID 21186265 DOI: 10.1093/brain/awq341  1
2011 Delay C, Calon F, Mathews P, Hébert SS. Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function Molecular Neurodegeneration. 6. DOI: 10.1186/1750-1326-6-70  1
2010 Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, et al. Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 7969-74. PMID 20385796 DOI: 10.1073/pnas.1001056107  0.4
2010 Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proceedings of the National Academy of Sciences of the United States of America. 107: 1630-5. PMID 20080541 DOI: 10.1073/pnas.0908953107  1
2010 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia Neuroforum. 16: 164-167.  1
2009 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience. 12: 1361-3. PMID 19838177 DOI: 10.1038/nn.2432  1
2009 Morales-Corraliza J, Mazzella MJ, Berger JD, Diaz NS, Choi JH, Levy E, Matsuoka Y, Planel E, Mathews PM. In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice. Plos One. 4: e7134. PMID 19771166 DOI: 10.1371/journal.pone.0007134  1
2009 Choi JH, Berger JD, Mazzella MJ, Morales-Corraliza J, Cataldo AM, Nixon RA, Ginsberg SD, Levy E, Mathews PM. Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. Journal of Neurochemistry. 110: 1818-27. PMID 19619138 DOI: 10.1111/j.1471-4159.2009.06277.x  1
2009 Mi W, Jung SS, Yu H, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E. Complexes of amyloid-beta and cystatin C in the human central nervous system. Journal of Alzheimer's Disease : Jad. 18: 273-80. PMID 19584436 DOI: 10.3233/JAD-2009-1147  1
2009 Bernardo A, Harrison FE, McCord M, Zhao J, Bruchey A, Davies SS, Jackson Roberts L, Mathews PM, Matsuoka Y, Ariga T, Yu RK, Thompson R, McDonald MP. Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice. Neurobiology of Aging. 30: 1777-91. PMID 18258340 DOI: 10.1016/j.neurobiolaging.2007.12.022  1
2008 Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 118: 2796-807. PMID 18596919 DOI: 10.1172/JCI34254  1
2008 Cataldo AM, Mathews PM, Boiteau AB, Hassinger LC, Peterhoff CM, Jiang Y, Mullaney K, Neve RL, Gruenberg J, Nixon RA. Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. The American Journal of Pathology. 173: 370-84. PMID 18535180 DOI: 10.2353/ajpath.2008.071053  1
2008 Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, Bagshaw R, Mathews PM, Fraser PE, Westaway D, St George-Hyslop P, Schmitt-Ulms G. The in vivo brain interactome of the amyloid precursor protein. Molecular & Cellular Proteomics : McP. 7: 15-34. PMID 17934213 DOI: 10.1074/mcp.M700077-MCP200  1
2007 Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nature Genetics. 39: 1440-2. PMID 18026100 DOI: 10.1038/ng.2007.29  1
2007 Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. Journal of Neurochemistry. 102: 619-26. PMID 17630980 DOI: 10.1111/j.1471-4159.2007.04587.x  1
2007 Elder GA, Cho JY, English DF, Franciosi S, Schmeidler J, Sosa MA, Gasperi RD, Fisher EA, Mathews PM, Haroutunian V, Buxbaum JD. Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor. Journal of Neurochemistry. 102: 1220-31. PMID 17472705 DOI: 10.1111/j.1471-4159.2007.04614.x  1
2007 Dorval V, Mazzella MJ, Mathews PM, Hay RT, Fraser PE. Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins. The Biochemical Journal. 404: 309-16. PMID 17346237 DOI: 10.1042/BJ20061451  1
2006 Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima-Ando K, Iijima K, Mathews PM, Itohara S, Gandy S, Suzuki T. Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. Plos One. 1: e51. PMID 17183681 DOI: 10.1371/journal.pone.0000051  1
2006 Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. The Journal of Clinical Investigation. 116: 3060-9. PMID 17080199 DOI: 10.1172/JCI27341  1
2006 Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (New York, N.Y.). 313: 1781-4. PMID 16990547 DOI: 10.1126/science.1131864  1
2006 Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. Embo Reports. 7: 940-6. PMID 16906128 DOI: 10.1038/sj.embor.7400784  1
2006 Tate BA, Mathews PM. Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment. Science of Aging Knowledge Environment : Sage Ke. 2006: re2. PMID 16807486 DOI: 10.1126/sageke.2006.10.re2  1
2005 Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, et al. Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. The Journal of Cell Biology. 171: 87-98. PMID 16203860 DOI: 10.1083/jcb.200505082  1
2005 Schmidt SD, Nixon RA, Mathews PM. ELISA method for measurement of amyloid-beta levels. Methods in Molecular Biology (Clifton, N.J.). 299: 279-97. PMID 15980612 DOI: 10.1385/1-59259-874-9:279  1
2005 Schmidt SD, Jiang Y, Nixon RA, Mathews PM. Tissue processing prior to protein analysis and amyloid-beta quantitation. Methods in Molecular Biology (Clifton, N.J.). 299: 267-78. PMID 15980611  1
2005 Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, et al. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proceedings of the National Academy of Sciences of the United States of America. 102: 8972-7. PMID 15951428 DOI: 10.1073/pnas.0500940102  1
2004 Carter TL, Verdile G, Groth D, Bogush A, Thomas S, Shen P, Fraser PE, Mathews P, Nixon RA, Ehrlich ME, Kwok JB, St George-Hyslop P, Schofield P, Li Y, Yang A, et al. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Disease and Associated Disorders. 18: 261-3. PMID 15592142  1
2004 Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T. A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. The American Journal of Pathology. 165: 937-48. PMID 15331417  1
2004 Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. Journal of Neuropathology and Experimental Neurology. 63: 821-30. PMID 15330337  1
2004 Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai T, Katayama T, Schmidt SD, Mathews PM, Schmitt-Ulms G, Fraser PE, St George-Hyslop P. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. The Journal of Biological Chemistry. 279: 46455-63. PMID 15322109 DOI: 10.1074/jbc.M406289200  1
2004 Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman ML, Staufenbiel M, Mathews PM, Jucker M. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nature Neuroscience. 7: 954-60. PMID 15311281 DOI: 10.1038/nn1302  1
2004 Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, ... ... Mathews PM, et al. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of Neurochemistry. 90: 1011-8. PMID 15287908 DOI: 10.1111/j.1471-4159.2004.02532.x  1
2004 Lacombe P, Mathews PM, Schmidt SD, Breidert T, Heneka MT, Landreth GE, Feinstein DL, Galea E. Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised. Journal of Neuroinflammation. 1: 11. PMID 15285804 DOI: 10.1186/1742-2094-1-11  1
2004 Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V, Schmidt SD, Nixon RA, Frangione B, Levy E. Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiology of Aging. 25: 1033-43. PMID 15212828 DOI: 10.1016/j.neurobiolaging.2003.11.006  1
2004 Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O. Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Annals of Neurology. 55: 801-14. PMID 15174014 DOI: 10.1002/ana.20101  1
2004 Pastorino L, Ikin AF, Lamprianou S, Vacaresse N, Revelli JP, Platt K, Paganetti P, Mathews PM, Harroch S, Buxbaum JD. BACE (beta-secretase) modulates the processing of APLP2 in vivo. Molecular and Cellular Neurosciences. 25: 642-9. PMID 15080893 DOI: 10.1016/j.mcn.2003.12.013  1
2004 Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Näslund J. Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis. The Journal of Biological Chemistry. 279: 23925-32. PMID 15051718 DOI: 10.1074/jbc.M401277200  1
2004 Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. Journal of Neurochemistry. 89: 44-53. PMID 15030388 DOI: 10.1046/j.1471-4159.2003.02298.x  1
2004 Verdile G, Groth D, Mathews PM, St George-Hyslop P, Fraser PE, Ramabhadran TV, Kwok JB, Schofield PR, Carter T, Gandy S, Martins RN. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells. Molecular Psychiatry. 9: 594-602. PMID 14993906 DOI: 10.1038/  1
2004 Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD, Nixon RA, Levy E. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide. Journal of Molecular Neuroscience : Mn. 22: 13-8. PMID 14742906 DOI: 10.1385/JMN:22:1-2:13  1
2003 Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, et al. In vivo reduction of amyloid-beta by a mutant copper transporter. Proceedings of the National Academy of Sciences of the United States of America. 100: 14193-8. PMID 14617772 DOI: 10.1073/pnas.2332851100  1
2003 Mathews PM, Nixon RA. Setback for an Alzheimer's disease vaccine: lessons learned. Neurology. 61: 7-8. PMID 12847147 DOI: 10.1212/WNL.61.1.7  1
2003 Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5645-9. PMID 12843267  1
2003 Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. The Journal of Biological Chemistry. 278: 31261-8. PMID 12761223 DOI: 10.1074/jbc.M304122200  1
2003 Meyer-Luehmann M, Stalder M, Herzig MC, Kaeser SA, Kohler E, Pfeifer M, Boncristiano S, Mathews PM, Mercken M, Abramowski D, Staufenbiel M, Jucker M. Extracellular amyloid formation and associated pathology in neural grafts. Nature Neuroscience. 6: 370-7. PMID 12598899 DOI: 10.1038/nn1022  1
2003 Atwood CS, Perry G, Smith MA. Cerebral hemorrhage and amyloid-beta. Science (New York, N.Y.). 299: 1014; author reply 1. PMID 12586924 DOI: 10.1126/science.299.5609.1014a  1
2002 Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews PM, Jucker M. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science (New York, N.Y.). 298: 1379. PMID 12434053 DOI: 10.1126/science.1078259  1
2002 Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, et al. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proceedings of the National Academy of Sciences of the United States of America. 99: 14452-7. PMID 12388777 DOI: 10.1073/pnas.222413999  1
2002 Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA. Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments. The Journal of Biological Chemistry. 277: 36415-24. PMID 12087104 DOI: 10.1074/jbc.M205208200  1
2002 Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, et al. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. The Journal of Biological Chemistry. 277: 28135-42. PMID 12032140 DOI: 10.1074/jbc.M110871200  1
2002 Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, Levesque G, Yu G, Nishimura M, Mathews P, Schmidt SD, Mercken M, Bergeron C, Westaway D, St George-Hyslop P. Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP. Neurobiology of Aging. 23: 187-94. PMID 11804702 DOI: 10.1016/S0197-4580(01)00267-6  1
2002 Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis. The Journal of Biological Chemistry. 277: 5299-307. PMID 11551970 DOI: 10.1074/jbc.M108161200  1
2001 Nixon RA, Mathews PM, Cataldo AM. The neuronal endosomal-lysosomal system in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 3: 97-107. PMID 12214078  1
2000 Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408: 979-82. PMID 11140685 DOI: 10.1038/35050110  1
2000 Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, et al. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine (Cambridge, Mass.). 6: 878-91. PMID 11126202  1
2000 Nixon RA, Cataldo AM, Mathews PM. The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochemical Research. 25: 1161-72. PMID 11059790  1
1999 Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657  1
1998 Chen PX, Mathews PM, Good PJ, Rossier BC, Geering K. Unusual degradation of alpha-beta complexes in Xenopus oocytes by beta-subunits of Xenopus gastric H-K-ATPase. The American Journal of Physiology. 275: C139-45. PMID 9688844  1
1997 Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grünberg J, Mathews P, Nixon R, Dotti C, Haass C. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. Journal of Neurochemistry. 69: 2432-40. PMID 9375676  1
1996 Beggah A, Mathews P, Beguin P, Geering K. Degradation and endoplasmic reticulum retention of unassembled α- and β-subunits of Na,K-ATPase correlate with interaction of BiP Journal of Biological Chemistry. 271: 20895-20902. PMID 8702846 DOI: 10.1074/jbc.271.34.20895  1
1995 Mathews PM, Claeys D, Jaisser F, Geering K, Horisberger JD, Kraehenbuhl JP, Rossier BC. Primary structure and functional expression of the mouse and frog alpha-subunit of the gastric H(+)-K(+)-ATPase. The American Journal of Physiology. 268: C1207-14. PMID 7762614  1
1995 Modyanov NN, Mathews PM, Grishin AV, Beguin P, Beggah AT, Rossier BC, Horisberger JD, Geering K. Human ATP1AL1 gene encodes a ouabain-sensitive H-K-ATPase. The American Journal of Physiology. 269: C992-7. PMID 7485470 DOI: 10.1152/AJPCELL.1995.269.4.C992  1
1994 Beguin P, Beggah AT, Chibalin AV, Burgener-Kairuz P, Jaisser F, Mathews PM, Rossier BC, Cotecchia S, Geering K. Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation. The Journal of Biological Chemistry. 269: 24437-45. PMID 7929106  1
1993 Geering K, Jaunin P, Jaisser F, Mérillat AM, Horisberger JD, Mathews PM, Lemas V, Fambrough DM, Rossier BC. Mutation of a conserved proline residue in the beta-subunit ectodomain prevents Na(+)-K(+)-ATPase oligomerization. The American Journal of Physiology. 265: C1169-74. PMID 8238307  1
1993 Geerling K, Jaunin P, Jaisser F, Merillat AM, Horisberger JD, Mathews PM, Lemas V, Fambrough DM, Rossier BC. Mutation of a conserved proline residue in the beta-subunit ectodomain prevents Na+-K+-ATPase oligomerization Am.J.Physiol.. 265: C1169-C1174.  1
1992 Mathews PM, Martinie JB, Fambrough DM. The pathway and targeting signal for delivery of the integral membrane glycoprotein LEP100 to lysosomes. The Journal of Cell Biology. 118: 1027-40. PMID 1512288  1
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