| Year |
Citation |
Score |
| 2023 |
Zheng C, Javitch JA, Lambert NA, Donthamsetti P, Gurevich VV. In-Cell Arrestin-Receptor Interaction Assays. Current Protocols. 3: e890. PMID 37787634 DOI: 10.1002/cpz1.890 |
0.529 |
|
| 2023 |
Chancey JH, Kellendonk C, Javitch JA, Lovinger DM. Dopaminergic D2 receptor modulation of striatal cholinergic interneurons contributes to sequence learning. Biorxiv : the Preprint Server For Biology. PMID 37693570 DOI: 10.1101/2023.08.28.554807 |
0.596 |
|
| 2023 |
Serafini RA, Estill M, Pekarskaya EA, Sakloth F, Shen L, Javitch JA, Zachariou V. Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 37474762 DOI: 10.1038/s41386-023-01645-w |
0.77 |
|
| 2023 |
Jobin ML, De Smedt-Peyrusse V, Ducrocq F, Baccouch R, Oummadi A, Pedersen MH, Medel-Lacruz B, Angelo MF, Villette S, Van Delft P, Fouillen L, Mongrand S, Selent J, Tolentino-Cortez T, Barreda-Gómez G, ... ... Javitch JA, et al. Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. Molecular Psychiatry. PMID 36604603 DOI: 10.1038/s41380-022-01928-6 |
0.315 |
|
| 2022 |
Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, ... ... Javitch JA, et al. GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell. PMID 35483373 DOI: 10.1016/j.cell.2022.03.042 |
0.523 |
|
| 2022 |
Karam CS, Williams BL, Morozova I, Yuan Q, Panarsky R, Zhang Y, Hodgkinson CA, Goldman D, Kalachikov S, Javitch JA. Functional Genomic Analysis of Amphetamine Sensitivity in . Frontiers in Psychiatry. 13: 831597. PMID 35250674 DOI: 10.3389/fpsyt.2022.831597 |
0.783 |
|
| 2021 |
Pekarskaya EA, Holt ES, Gingrich JA, Ansorge MS, Javitch JA, Canetta SE. Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine. Scientific Reports. 11: 22852. PMID 34819526 DOI: 10.1038/s41598-021-02074-9 |
0.768 |
|
| 2021 |
Gallo EF, Greenwald J, Yeisley J, Teboul E, Martyniuk KM, Villarin JM, Li Y, Javitch JA, Balsam PD, Kellendonk C. Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning. Molecular Psychiatry. PMID 34789847 DOI: 10.1038/s41380-021-01364-y |
0.807 |
|
| 2021 |
Perry-Hauser NA, Asher WB, Hauge Pedersen M, Javitch JA. Assays for detecting arrestin interaction with GPCRs. Methods in Cell Biology. 166: 43-65. PMID 34752339 DOI: 10.1016/bs.mcb.2021.06.007 |
0.783 |
|
| 2021 |
Han J, Andreu V, Langreck C, Pekarskaya EA, Grinnell SG, Allain F, Magalong V, Pintar J, Kieffer BL, Harris AZ, Javitch JA, Hen R, Nautiyal KM. Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34593976 DOI: 10.1038/s41386-021-01192-2 |
0.778 |
|
| 2021 |
de Jong JO, Llapashtica C, Genestine M, Strauss K, Provenzano F, Sun Y, Zhu H, Cortese GP, Brundu F, Brigatti KW, Corneo B, Migliori B, Tomer R, Kushner SA, Kellendonk C, ... Javitch JA, et al. Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder. Nature Communications. 12: 4087. PMID 34471112 DOI: 10.1038/s41467-021-24358-4 |
0.545 |
|
| 2021 |
Simpson EH, Gallo EF, Balsam PD, Javitch JA, Kellendonk C. How changes in dopamine D2 receptor levels alter striatal circuit function and motivation. Molecular Psychiatry. PMID 34385603 DOI: 10.1038/s41380-021-01253-4 |
0.82 |
|
| 2021 |
Karam CS, Williams BL, Jones SK, Javitch JA. The Role of the Dopamine Transporter in the Effects of Amphetamine on Sleep and Sleep Architecture in Drosophila. Neurochemical Research. PMID 33630236 DOI: 10.1007/s11064-021-03275-4 |
0.779 |
|
| 2021 |
Uprety R, Che T, Zaidi SA, Grinnell SG, Varga BR, Faouzi A, Slocum ST, Allaoa A, Varadi A, Nelson M, Bernhard SM, Kulko E, LeRouzic V, Eans SO, Simons CA, ... ... Javitch JA, et al. Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site. Elife. 10. PMID 33555255 DOI: 10.7554/eLife.56519 |
0.794 |
|
| 2020 |
Guthrie D, Klein Herenbrink C, Lycas M, Ku T, Bonifazi A, DeVree B, Mathiasen S, Javitch J, Grimm JB, Lavis LD, Gether U, Newman AH. Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter. Acs Chemical Neuroscience. PMID 32926777 DOI: 10.1021/Acschemneuro.0C00397 |
0.402 |
|
| 2020 |
Okashah N, Wright SC, Kawakami K, Mathiasen S, Zhou J, Lu S, Javitch JA, Inoue A, Bouvier M, Lambert NA. Agonist-induced formation of unproductive receptor-G complexes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32817560 DOI: 10.1073/Pnas.2003787117 |
0.326 |
|
| 2020 |
Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA. G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. Nature Chemical Biology. PMID 32778842 DOI: 10.1038/S41589-020-0617-7 |
0.387 |
|
| 2020 |
Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, ... ... Javitch JA, et al. Structure of human GABA receptor in an inactive state. Nature. PMID 32581365 DOI: 10.1038/S41586-020-2452-0 |
0.347 |
|
| 2020 |
Fulton MG, Loch MT, Rodriguez AL, Lin X, Javitch JA, Conn PJ, Niswender CM, Lindsley CW. Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu heterodimeric receptor results in a compound with mGlu homodimer selectivity. Bioorganic & Medicinal Chemistry Letters. 127212. PMID 32371100 DOI: 10.1016/J.Bmcl.2020.127212 |
0.363 |
|
| 2020 |
Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, ... ... Javitch JA, et al. Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells. Science Advances. 6: eaay9572. PMID 32270040 DOI: 10.1126/Sciadv.Aay9572 |
0.608 |
|
| 2020 |
Patel M, Manning JJ, Finlay DB, Javitch JA, Banister SD, Grimsey NL, Glass M. Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists. Biochemical Pharmacology. 113871. PMID 32088263 DOI: 10.1016/J.Bcp.2020.113871 |
0.39 |
|
| 2020 |
Gotfryd K, Boesen T, Mortensen JS, Khelashvili G, Quick M, Terry DS, Missel JW, LeVine MV, Gourdon P, Blanchard SC, Javitch JA, Weinstein H, Loland CJ, Nissen P, Gether U. X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature Communications. 11: 1005. PMID 32081981 DOI: 10.1038/S41467-020-14735-W |
0.312 |
|
| 2020 |
Lane JR, Abramyan AM, Adhikari P, Keen AC, Lee KH, Sanchez J, Verma RK, Lim HD, Yano H, Javitch JA, Shi L. Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism. Elife. 9. PMID 31985399 DOI: 10.7554/Elife.52189 |
0.609 |
|
| 2020 |
Zhu Y, Dwork AJ, Trifilieff P, Javitch JA. Detection of G Protein-Coupled Receptor Complexes in Postmortem Human Brain by Proximity Ligation Assay. Current Protocols in Neuroscience. 91: e86. PMID 31943888 DOI: 10.1002/Cpns.86 |
0.338 |
|
| 2020 |
Lane JR, Abramyan AM, Adhikari P, Keen AC, Lee K, Sanchez J, Verma RK, Lim HD, Yano H, Javitch JA, Shi L. Author response: Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism Elife. DOI: 10.7554/Elife.52189.Sa2 |
0.6 |
|
| 2019 |
Welch AC, Zhang J, Lyu J, McMurray MS, Javitch JA, Kellendonk C, Dulawa SC. Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice. Molecular Psychiatry. PMID 31863019 DOI: 10.1038/S41380-019-0633-8 |
0.614 |
|
| 2019 |
Zhu Y, Mészáros J, Walle R, Fan R, Sun Z, Dwork AJ, Trifilieff P, Javitch JA. Detecting G protein-coupled receptor complexes in postmortem human brain with proximity ligation assay and a Bayesian classifier. Biotechniques. PMID 31859535 DOI: 10.2144/Btn-2019-0083 |
0.39 |
|
| 2019 |
Fitzgerald GA, Terry DS, Warren AL, Quick M, Javitch JA, Blanchard SC. Quantifying secondary transport at single-molecule resolution. Nature. 575: 528-534. PMID 31723269 DOI: 10.1038/S41586-019-1747-5 |
0.324 |
|
| 2019 |
Finlay DB, Manning JJ, Ibsen MS, Macdonald CE, Patel M, Javitch JA, Banister SD, Glass M. Do toxic synthetic cannabinoid receptor agonists have signature in vitro activity profiles? A case study of AMB-FUBINACA. Acs Chemical Neuroscience. PMID 31513380 DOI: 10.1021/Acschemneuro.9B00429 |
0.389 |
|
| 2019 |
Klein Herenbrink C, Verma R, Lim HD, Kopinathan A, Keen A, Shonberg J, Draper-Joyce CJ, Scammells PJ, Christopoulos A, Javitch JA, Capuano B, Shi L, Lane JR. Molecular determinants of the intrinsic efficacy of the antipsychotic aripiprazole. Acs Chemical Biology. PMID 31339684 DOI: 10.1021/Acschembio.9B00342 |
0.418 |
|
| 2019 |
LeVine MV, Terry DS, Khelashvili G, Siegel ZS, Quick M, Javitch JA, Blanchard SC, Weinstein H. The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31324743 DOI: 10.1073/Pnas.1903020116 |
0.347 |
|
| 2019 |
Donthamsetti PC, Broichhagen J, Vyklicky V, Stanley C, Fu Z, Visel M, Levitz JL, Javitch JA, Trauner D, Isacoff EY. Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor. Journal of the American Chemical Society. PMID 31291105 DOI: 10.1021/Jacs.9B02895 |
0.379 |
|
| 2019 |
Kruegel AC, Uprety R, Grinnell SG, Langreck C, Pekarskaya EA, Le Rouzic V, Ansonoff M, Gassaway MM, Pintar JE, Pasternak GW, Javitch JA, Majumdar S, Sames D. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. Acs Central Science. 5: 992-1001. PMID 31263758 DOI: 10.1021/Acscentsci.9B00141 |
0.77 |
|
| 2019 |
Karam CS, Jones SK, Javitch JA. Come Fly with Me: an overview of dopamine receptors in Drosophila melanogaster. Basic & Clinical Pharmacology & Toxicology. PMID 31219669 DOI: 10.1111/Bcpt.13277 |
0.431 |
|
| 2019 |
Ibsen MS, Finlay DB, Patel M, Javitch JA, Glass M, Grimsey NL. Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence. Frontiers in Pharmacology. 10: 350. PMID 31024316 DOI: 10.3389/Fphar.2019.00350 |
0.398 |
|
| 2019 |
Schrader JM, Irving CM, Octeau JC, Christian JA, Aballo TJ, Kareemo DJ, Conti J, Camberg JL, Lane JR, Javitch JA, Kovoor A. The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell-surface. The Journal of Biological Chemistry. PMID 30670597 DOI: 10.1074/Jbc.Ra118.004682 |
0.477 |
|
| 2019 |
Farino ZJ, Morgenstern TJ, Maffei A, Quick M, De Solis AJ, Wiriyasermkul P, Freyberg RJ, Aslanoglou D, Sorisio D, Inbar BP, Free RB, Donthamsetti P, Mosharov EV, Kellendonk C, Schwartz GJ, ... ... Javitch JA, et al. New roles for dopamine D and D receptors in pancreatic beta cell insulin secretion. Molecular Psychiatry. PMID 30626912 DOI: 10.1038/S41380-018-0344-6 |
0.809 |
|
| 2019 |
Freyberg Z, Farino Z, Morgenstern T, Maffei A, Quick M, De Solis A, Wiriyasermkul P, Freyberg R, Aslanoglou D, Sorisio D, Inbar B, Free RB, Donthamsetti P, Mosharov E, Kellendonk C, ... ... Javitch J, et al. 50. New Roles for Peripheral Dopamine D2-Like Receptors in Antipsychotic Drug-Induced Metabolic Dysfunction Biological Psychiatry. 85: S21. DOI: 10.1016/J.Biopsych.2019.03.064 |
0.781 |
|
| 2018 |
Sykes DA, Lane JR, Szabo M, Capuano B, Javitch JA, Charlton SJ. Reply to 'Antipsychotics with similar association kinetics at dopamine D receptors differ in extrapyramidal side-effects'. Nature Communications. 9: 3568. PMID 30177696 DOI: 10.1038/S41467-018-05678-4 |
0.445 |
|
| 2018 |
Donthamsetti P, Gallo EF, Buck DC, Stahl EL, Zhu Y, Lane JR, Bohn LM, Neve KA, Kellendonk C, Javitch JA. Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation. Molecular Psychiatry. PMID 30120413 DOI: 10.1038/S41380-018-0212-4 |
0.827 |
|
| 2018 |
Quick M, Abramyan AM, Wiriyasermkul P, Weinstein H, Shi L, Javitch JA. The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites. Proceedings of the National Academy of Sciences of the United States of America. PMID 30082383 DOI: 10.1073/Pnas.1717444115 |
0.704 |
|
| 2018 |
Yano H, Cai NS, Javitch JA, Ferré S. Luciferase complementation based-detection of G-protein-coupled receptor activity. Biotechniques. 65: 9-14. PMID 30014734 DOI: 10.2144/Btn-2018-0039 |
0.543 |
|
| 2018 |
Abramyan AM, Quick M, Xue C, Javitch JA, Shi L. Exploring substrate binding in the extracellular vestibule of MhsT by atomistic simulations and Markov models. Journal of Chemical Information and Modeling. PMID 29851339 DOI: 10.1021/Acs.Jcim.8B00175 |
0.317 |
|
| 2018 |
Marcott PF, Gong S, Donthamsetti P, Grinnell SG, Nelson MN, Newman AH, Birnbaumer L, Martemyanov KA, Javitch JA, Ford CP. Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens. Neuron. PMID 29656874 DOI: 10.1016/J.Neuron.2018.03.038 |
0.806 |
|
| 2018 |
Gallo EF, Meszaros J, Sherman JD, Chohan MO, Teboul E, Choi CS, Moore H, Javitch JA, Kellendonk C. Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum. Nature Communications. 9: 1086. PMID 29540712 DOI: 10.1038/S41467-018-03272-2 |
0.808 |
|
| 2018 |
Karam CS, Javitch JA. Phosphorylation of the Amino Terminus of the Dopamine Transporter: Regulatory Mechanisms and Implications for Amphetamine Action. Advances in Pharmacology (San Diego, Calif.). 82: 205-234. PMID 29413521 DOI: 10.1016/Bs.Apha.2017.09.002 |
0.459 |
|
| 2018 |
Yano H, Cai NS, Xu M, Verma RK, Rea W, Hoffman AF, Shi L, Javitch JA, Bonci A, Ferré S. Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor. Nature Communications. 9: 486. PMID 29402888 DOI: 10.1038/S41467-017-02606-W |
0.637 |
|
| 2018 |
Draper-Joyce CJ, Verma RK, Michino M, Shonberg J, Kopinathan A, Klein Herenbrink C, Scammells PJ, Capuano B, Abramyan AM, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR. The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions. Scientific Reports. 8: 1208. PMID 29352161 DOI: 10.1038/S41598-018-19642-1 |
0.425 |
|
| 2018 |
Verma RK, Abramyan AM, Michino M, Free RB, Sibley DR, Javitch JA, Lane JR, Shi L. The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors. Plos Computational Biology. 14: e1005948. PMID 29337986 DOI: 10.1371/Journal.Pcbi.1005948 |
0.364 |
|
| 2018 |
Terry DS, Kolster RA, Quick M, LeVine MV, Khelashvili G, Zhou Z, Weinstein H, Javitch JA, Blanchard SC. A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport. Nature Communications. 9: 230. PMID 29335402 DOI: 10.1038/S41467-017-02202-Y |
0.352 |
|
| 2018 |
Draper-Joyce CJ, Michino M, Verma RK, Herenbrink CK, Shonberg J, Kopinathan A, Scammells PJ, Capuano B, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR. The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor. Biochemical Pharmacology. PMID 29325769 DOI: 10.1016/J.Bcp.2018.01.002 |
0.408 |
|
| 2017 |
Donthamsetti P, Winter N, Schönberger M, Levitz J, Stanley C, Javitch JA, Isacoff EY, Trauner D. Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist. Journal of the American Chemical Society. PMID 29166564 DOI: 10.1021/Jacs.7B07659 |
0.441 |
|
| 2017 |
Clark AM, Leroy F, Martyniuk KM, Feng W, McManus E, Bailey MR, Javitch JA, Balsam PD, Kellendonk C. Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization. Eneuro. 4. PMID 29071300 DOI: 10.1523/ENEURO.0227-17.2017 |
0.652 |
|
| 2017 |
Yano H, Provasi D, Cai NS, Filizola M, Ferre S, Javitch JA. Development of novel biosensors to study receptor-mediated activation of Gs and Golf. The Journal of Biological Chemistry. PMID 29042444 DOI: 10.1074/Jbc.M117.800698 |
0.617 |
|
| 2017 |
Sykes DA, Moore H, Stott L, Holliday N, Javitch JA, Lane JR, Charlton SJ. Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors. Nature Communications. 8: 763. PMID 28970469 DOI: 10.1038/S41467-017-00716-Z |
0.42 |
|
| 2017 |
Aguilar JI, Dunn M, Mingote S, Karam CS, Farino ZJ, Sonders MS, Choi SJ, Grygoruk A, Zhang Y, Cela C, Choi BJ, Flores J, Freyberg RJ, McCabe BD, Mosharov EV, ... ... Javitch JA, et al. Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT. Neuron. PMID 28823729 DOI: 10.1016/J.Neuron.2017.07.038 |
0.687 |
|
| 2017 |
Gregorio GG, Masureel M, Hilger D, Terry DS, Juette M, Zhao H, Zhou Z, Perez-Aguilar JM, Hauge M, Mathiasen S, Javitch JA, Weinstein H, Kobilka BK, Blanchard SC. Single-molecule analysis of ligand efficacy in β2AR-G-protein activation. Nature. PMID 28607487 DOI: 10.1038/Nature22354 |
0.362 |
|
| 2017 |
Karam CS, Sen N, Javitch JA. Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter. Journal of Chemical Neuroanatomy. PMID 28571709 DOI: 10.1016/J.Jchemneu.2017.05.003 |
0.392 |
|
| 2017 |
Stolzenberg S, Li Z, Quick M, Malinauskaite L, Nissen P, Weinstein H, Javitch JA, Shi L. The Role of TM5 in Na2 Release and the Conformational Transition of Neurotransmitter:Sodium Symporters toward the Inward-Open State. The Journal of Biological Chemistry. PMID 28320858 DOI: 10.1074/Jbc.M116.757153 |
0.329 |
|
| 2017 |
Samuels BA, Nautiyal KM, Kruegel AC, Levinstein MR, Magalong VM, Gassaway MM, Grinnell SG, Han J, Ansonoff MA, Pintar JE, Javitch JA, Sames D, Hen R. The Behavioral Effects of the Antidepressant Tianeptine Require the Mu Opioid Receptor. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28303899 DOI: 10.1038/Npp.2017.60 |
0.779 |
|
| 2017 |
Rives ML, Javitch JA, Wickenden AD. Potentiating SLC Transporter Activity: Emerging Drug Discovery Opportunities. Biochemical Pharmacology. PMID 28214518 DOI: 10.1016/J.Bcp.2017.02.010 |
0.353 |
|
| 2016 |
Michino M, Boateng CA, Donthamsetti P, Yano H, Bakare OM, Bonifazi A, Ellenberger MP, Keck TM, Kumar V, Zhu C, Verma R, Deschamps JR, Javitch JA, Newman AH, Shi L. Towards understanding the structural basis of partial agonism at the dopamine D3 receptor. Journal of Medicinal Chemistry. PMID 27983845 DOI: 10.1021/Acs.Jmedchem.6B01148 |
0.631 |
|
| 2016 |
Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H. Conformational dynamics on the extracellular side of LeuT controlled by Na+ and K+ ions and the protonation state of E290. The Journal of Biological Chemistry. PMID 27474737 DOI: 10.1074/Jbc.M116.731455 |
0.302 |
|
| 2016 |
Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ. Development and antiparkinsonian activity of VU0418506, a selective positive allosteric modulator of metabotropic glutamate receptor 4 homomers without activity at mGlu2/4 heteromers. Acs Chemical Neuroscience. PMID 27441572 DOI: 10.1021/Acschemneuro.6B00036 |
0.384 |
|
| 2016 |
Kruegel AC, Gassaway MM, Kapoor A, Váradi A, Majumdar S, Filizola M, Javitch JA, Sames D. Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators. Journal of the American Chemical Society. PMID 27192616 DOI: 10.1021/Jacs.6B00360 |
0.378 |
|
| 2016 |
Zou MF, Keck TM, Kumar V, Donthamsetti P, Michino M, Burzynski C, Schweppe C, Bonifazi A, Free RB, Sibley DR, Janowsky A, Shi L, Javitch JA, Newman AH. Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. Journal of Medicinal Chemistry. PMID 27035329 DOI: 10.1021/Acs.Jmedchem.5B01612 |
0.401 |
|
| 2016 |
Klein Herenbrink C, Sykes DA, Donthamsetti P, Canals M, Coudrat T, Shonberg J, Scammells PJ, Capuano B, Sexton PM, Charlton SJ, Javitch JA, Christopoulos A, Lane JR. The role of kinetic context in apparent biased agonism at GPCRs. Nature Communications. 7: 10842. PMID 26905976 DOI: 10.1038/Ncomms10842 |
0.417 |
|
| 2016 |
Freyberg Z, Sonders MS, Aguilar JI, Hiranita T, Karam CS, Flores J, Pizzo AB, Zhang Y, Farino ZJ, Chen A, Martin CA, Kopajtic TA, Fei H, Hu G, Lin YY, ... ... Javitch JA, et al. Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain. Nature Communications. 7: 10652. PMID 26879809 DOI: 10.1038/Ncomms10652 |
0.704 |
|
| 2016 |
Farino ZJ, Morgenstern TJ, Vallaghe J, Gregor N, Donthamsetti P, Harris PE, Pierre N, Freyberg R, Charrier-Savournin F, Javitch JA, Freyberg Z. Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence. Plos One. 11: e0148684. PMID 26849707 DOI: 10.1371/Journal.Pone.0148684 |
0.643 |
|
| 2016 |
LeVine MV, Khelashvili G, Shi L, Quick M, Javitch JA, Weinstein H. The role of annular lipids in the functional properties of leucine transporter LeuT proteomicelles. Biochemistry. PMID 26811944 DOI: 10.1021/Acs.Biochem.5B01268 |
0.32 |
|
| 2015 |
Billesbølle CB, Krüger MB, Shi L, Quick M, Li Z, Stolzenberg S, Kniazeff J, Gotfryd K, Mortensen JS, Javitch JA, Weinstein H, Loland CJ, Gether U. Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter. The Journal of Biological Chemistry. PMID 26363074 DOI: 10.1074/Jbc.M115.677658 |
0.348 |
|
| 2015 |
Donthamsetti P, Quejada JR, Javitch JA, Gurevich VV, Lambert NA. Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. 70: 2.14.1-2.14.14. PMID 26331887 DOI: 10.1002/0471141755.Ph0214S70 |
0.575 |
|
| 2015 |
Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH. High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice. Journal of Medicinal Chemistry. 58: 6195-213. PMID 26203768 DOI: 10.1021/Acs.Jmedchem.5B00776 |
0.42 |
|
| 2015 |
Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L. Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. The Journal of Biological Chemistry. 290: 13992-4003. PMID 25869126 DOI: 10.1074/Jbc.M114.625343 |
0.37 |
|
| 2015 |
Bellot M, Galandrin S, Boularan C, Matthies HJ, Despas F, Denis C, Javitch J, Mazères S, Sanni SJ, Pons V, Seguelas MH, Hansen JL, Pathak A, Galli A, Sénard JM, et al. Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling. Nature Chemical Biology. 11: 271-9. PMID 25706338 DOI: 10.1038/Nchembio.1766 |
0.376 |
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| 2015 |
Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C. Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1609-18. PMID 25578797 DOI: 10.1038/Npp.2015.11 |
0.778 |
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| 2015 |
Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JA. Evidence against dopamine D1/D2 receptor heteromers. Molecular Psychiatry. PMID 25560761 DOI: 10.1038/Mp.2014.166 |
0.746 |
|
| 2015 |
Biezonski DK, Trifilieff P, Meszaros J, Javitch JA, Kellendonk C. Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse. The Journal of Comparative Neurology. 523: 1175-89. PMID 25556545 DOI: 10.1002/Cne.23730 |
0.672 |
|
| 2015 |
Michino M, Beuming T, Donthamsetti P, Newman AH, Javitch JA, Shi L. What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands? Pharmacological Reviews. 67: 198-213. PMID 25527701 DOI: 10.1124/Pr.114.009944 |
0.38 |
|
| 2015 |
Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH. High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice Journal of Medicinal Chemistry. 58: 6195-6213. DOI: 10.1021/acs.jmedchem.5b00776 |
0.306 |
|
| 2015 |
LeVine MV, Khelashvili G, Shi L, Quick M, Javitch J, Weinstein H. The Role of Annular Lipids in the Mechanism of Membrane Protein Solubilization and Formation of Functionally Competent Proteomicelles Biophysical Journal. 108: 461a. DOI: 10.1016/J.Bpj.2014.11.2517 |
0.305 |
|
| 2015 |
Michino M, Draper-Joyce CJ, Donthamsetti P, Javitch JA, Lane JR, Shi L. Structural Basis for the Allosteric Pharmacology of SB269652 in Dopamine D2 Receptor Biophysical Journal. 108: 416a. DOI: 10.1016/J.Bpj.2014.11.2279 |
0.441 |
|
| 2015 |
Li Z, Stolzenberg S, Quick M, Malinauskaite L, Nissen P, Weinstein H, Javitch JA, Shi L. A Key Role for TM5 in the Na+-Coupled Alternating-Access Mechanism Revealed by Computational Analysis of the MhsT Structures Biophysical Journal. 108: 29a. DOI: 10.1016/J.Bpj.2014.11.182 |
0.341 |
|
| 2014 |
Clayton CC, Donthamsetti P, Lambert NA, Javitch JA, Neve KA. Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor. The Journal of Biological Chemistry. 289: 33663-75. PMID 25336643 DOI: 10.1074/Jbc.M114.605378 |
0.425 |
|
| 2014 |
Malinauskaite L, Quick M, Reinhard L, Lyons JA, Yano H, Javitch JA, Nissen P. A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters. Nature Structural & Molecular Biology. 21: 1006-12. PMID 25282149 DOI: 10.1038/Nsmb.2894 |
0.554 |
|
| 2014 |
Gaskill PJ, Yano HH, Kalpana GV, Javitch JA, Berman JW. Dopamine receptor activation increases HIV entry into primary human macrophages. Plos One. 9: e108232. PMID 25268786 DOI: 10.1371/Journal.Pone.0108232 |
0.601 |
|
| 2014 |
Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B, Sexton PM, Javitch JA, Christopoulos A. A new mechanism of allostery in a G protein-coupled receptor dimer. Nature Chemical Biology. 10: 745-52. PMID 25108820 DOI: 10.1038/Nchembio.1593 |
0.444 |
|
| 2014 |
Hamilton PJ, Belovich AN, Khelashvili G, Saunders C, Erreger K, Javitch JA, Sitte HH, Weinstein H, Matthies HJ, Galli A. PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein. Nature Chemical Biology. 10: 582-9. PMID 24880859 DOI: 10.1038/Nchembio.1545 |
0.41 |
|
| 2014 |
Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, ... ... Javitch JA, et al. Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor. Molecular Pharmacology. 86: 96-105. PMID 24755247 DOI: 10.1124/Mol.113.090563 |
0.456 |
|
| 2014 |
Kazmier K, Sharma S, Quick M, Islam SM, Roux B, Weinstein H, Javitch JA, McHaourab HS. Conformational dynamics of ligand-dependent alternating access in LeuT. Nature Structural & Molecular Biology. 21: 472-9. PMID 24747939 DOI: 10.1038/Nsmb.2816 |
0.325 |
|
| 2014 |
Dehnes Y, Shan J, Beuming T, Shi L, Weinstein H, Javitch JA. Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry International. 73: 4-15. PMID 24576496 DOI: 10.1016/J.Neuint.2014.02.003 |
0.413 |
|
| 2014 |
White KL, Scopton AP, Rives ML, Bikbulatov RV, Polepally PR, Brown PJ, Kenakin T, Javitch JA, Zjawiony JK, Roth BL. Identification of novel functionally selective κ-opioid receptor scaffolds. Molecular Pharmacology. 85: 83-90. PMID 24113749 DOI: 10.1124/Mol.113.089649 |
0.382 |
|
| 2014 |
Pizzo AB, Karam CS, Zhang Y, Ma CL, McCabe BD, Javitch JA. Amphetamine-induced behavior requires CaMKII-dependent dopamine transporter phosphorylation. Molecular Psychiatry. 19: 279-81. PMID 23508128 DOI: 10.1038/Mp.2013.29 |
0.407 |
|
| 2013 |
Michino M, Donthamsetti P, Beuming T, Banala A, Duan L, Roux T, Han Y, Trinquet E, Newman AH, Javitch JA, Shi L. A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors. Molecular Pharmacology. 84: 854-64. PMID 24061855 DOI: 10.1124/Mol.113.087833 |
0.468 |
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| 2013 |
Gavalas A, Lan TH, Liu Q, Corrêa IR, Javitch JA, Lambert NA. Segregation of family A G protein-coupled receptor protomers in the plasma membrane. Molecular Pharmacology. 84: 346-52. PMID 23778362 DOI: 10.1124/Mol.113.086868 |
0.352 |
|
| 2013 |
Trifilieff P, Feng B, Urizar E, Winiger V, Ward RD, Taylor KM, Martinez D, Moore H, Balsam PD, Simpson EH, Javitch JA. Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation. Molecular Psychiatry. 18: 1025-33. PMID 23711983 DOI: 10.1038/Mp.2013.57 |
0.422 |
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| 2013 |
Kantcheva AK, Quick M, Shi L, Winther AM, Stolzenberg S, Weinstein H, Javitch JA, Nissen P. Chloride binding site of neurotransmitter sodium symporters. Proceedings of the National Academy of Sciences of the United States of America. 110: 8489-94. PMID 23641004 DOI: 10.1073/Pnas.1221279110 |
0.316 |
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| 2013 |
Rives ML, Javitch JA. Sensing conformational changes in metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 110: 5742-3. PMID 23542381 DOI: 10.1073/Pnas.1303736110 |
0.388 |
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| 2013 |
Negri A, Rives ML, Caspers MJ, Prisinzano TE, Javitch JA, Filizola M. Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening. Journal of Chemical Information and Modeling. 53: 521-6. PMID 23461591 DOI: 10.1021/Ci400019T |
0.405 |
|
| 2013 |
Pizzo AB, Karam CS, Zhang Y, Yano H, Freyberg RJ, Karam DS, Freyberg Z, Yamamoto A, McCabe BD, Javitch JA. The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila. Molecular Psychiatry. 18: 824-33. PMID 22710269 DOI: 10.1038/Mp.2012.82 |
0.76 |
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| 2013 |
Khelashvili G, LeVine MV, Shi L, Quick M, Javitch JA, Weinstein H. Like Fish Out of Water: Membrane Proteins in Detergent Micelles Biophysical Journal. 104: 113a. DOI: 10.1016/J.Bpj.2012.11.656 |
0.307 |
|
| 2013 |
Newman AH, Banala AK, Donthamsetti P, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Drug Design for Addiction - Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 181-182. DOI: 10.1016/B978-0-12-800044-1.00163-X |
0.304 |
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| 2013 |
Yano H, Provasi D, Filizola M, Javitch J. Towards Better Understanding of G(s) Coupling in Catecholamine Receptors Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 89-90. DOI: 10.1016/B978-0-12-800044-1.00076-3 |
0.495 |
|
| 2012 |
Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel RL, Harris PE. Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro. Molecular Endocrinology (Baltimore, Md.). 26: 1757-72. PMID 22915827 DOI: 10.1210/Me.2012-1101 |
0.64 |
|
| 2012 |
Rives ML, Rossillo M, Liu-Chen LY, Javitch JA. 6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment. The Journal of Biological Chemistry. 287: 27050-4. PMID 22736766 DOI: 10.1074/Jbc.C112.387332 |
0.414 |
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| 2012 |
Geng Y, Xiong D, Mosyak L, Malito DL, Kniazeff J, Chen Y, Burmakina S, Quick M, Bush M, Javitch JA, Pin JP, Fan QR. Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2. Nature Neuroscience. 15: 970-8. PMID 22660477 DOI: 10.1038/Nn.3133 |
0.351 |
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| 2012 |
Newman AH, Beuming T, Banala AK, Donthamsetti P, Pongetti K, LaBounty A, Levy B, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. Journal of Medicinal Chemistry. 55: 6689-99. PMID 22632094 DOI: 10.1021/Jm300482H |
0.419 |
|
| 2012 |
Conrad KL, Davis AR, Silberman Y, Sheffler DJ, Shields AD, Saleh SA, Sen N, Matthies HJ, Javitch JA, Lindsley CW, Winder DG. Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2253-66. PMID 22617356 DOI: 10.1038/Npp.2012.76 |
0.387 |
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| 2012 |
Quick M, Shi L, Zehnpfennig B, Weinstein H, Javitch JA. Experimental conditions can obscure the second high-affinity site in LeuT. Nature Structural & Molecular Biology. 19: 207-11. PMID 22245968 DOI: 10.1038/Nsmb.2197 |
0.317 |
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| 2012 |
Skinbjerg M, Sibley DR, Javitch JA, Abi-Dargham A. Imaging the high-affinity state of the dopamine D2 receptor in vivo: fact or fiction? Biochemical Pharmacology. 83: 193-8. PMID 21945484 DOI: 10.1016/J.Bcp.2011.09.008 |
0.406 |
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| 2012 |
Sharma S, Stein RA, Quick M, Stolzenberg S, Shi L, Weinstein H, Javitch JA, Mchaourab HS. Conformational Dynamics in the Transport Cycle of Leucine Transporter on the Extracellular-Side Biophysical Journal. 102: 606a. DOI: 10.1016/J.Bpj.2011.11.3304 |
0.348 |
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| 2012 |
Kazmier K, Quick M, Shi L, Weinstein H, Javitch JA, Mchaourab HS. Structure, Dynamics, and Mechanism of the Leucine Transporter Studied by Double Electron Electron Resonance Spectroscopy Biophysical Journal. 102: 606a. DOI: 10.1016/J.Bpj.2011.11.3303 |
0.354 |
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| 2011 |
Rappold PM, Cui M, Chesser AS, Tibbett J, Grima JC, Duan L, Sen N, Javitch JA, Tieu K. Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3. Proceedings of the National Academy of Sciences of the United States of America. 108: 20766-71. PMID 22143804 DOI: 10.1073/Pnas.1115141108 |
0.419 |
|
| 2011 |
Allen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, ... ... Javitch JA, et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proceedings of the National Academy of Sciences of the United States of America. 108: 18488-93. PMID 22025698 DOI: 10.1073/Pnas.1104807108 |
0.393 |
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| 2011 |
Trifilieff P, Rives ML, Urizar E, Piskorowski RA, Vishwasrao HD, Castrillon J, Schmauss C, Slättman M, Gullberg M, Javitch JA. Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum. Biotechniques. 51: 111-8. PMID 21806555 DOI: 10.2144/000113719 |
0.44 |
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| 2011 |
Urizar E, Yano H, Kolster R, Galés C, Lambert N, Javitch JA. CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Nature Chemical Biology. 7: 624-30. PMID 21785426 DOI: 10.1038/Nchembio.623 |
0.636 |
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| 2011 |
Zhao Y, Terry DS, Shi L, Quick M, Weinstein H, Blanchard SC, Javitch JA. Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature. 474: 109-13. PMID 21516104 DOI: 10.1038/Nature09971 |
0.392 |
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| 2011 |
Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson WA, Javitch JA, Rajashankar KR, Zhou M. Crystal structure of a phosphorylation-coupled saccharide transporter. Nature. 473: 50-4. PMID 21471968 DOI: 10.1038/Nature09939 |
0.332 |
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| 2011 |
Cremona ML, Matthies HJ, Pau K, Bowton E, Speed N, Lute BJ, Anderson M, Sen N, Robertson SD, Vaughan RA, Rothman JE, Galli A, Javitch JA, Yamamoto A. Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nature Neuroscience. 14: 469-77. PMID 21399631 DOI: 10.1038/Nn.2781 |
0.415 |
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| 2011 |
Shan J, Javitch JA, Shi L, Weinstein H. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. Plos One. 6: e16350. PMID 21298009 DOI: 10.1371/Journal.Pone.0016350 |
0.39 |
|
| 2011 |
Johnston JM, Aburi M, Provasi D, Bortolato A, Urizar E, Lambert NA, Javitch JA, Filizola M. Making structural sense of dimerization interfaces of delta opioid receptor homodimers. Biochemistry. 50: 1682-90. PMID 21261298 DOI: 10.1021/Bi101474V |
0.356 |
|
| 2011 |
Slifstein M, Suckow RF, Javitch JA, Cooper T, Lieberman J, Abi-Dargham A. Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [11C] NNC112 and [11C] raclopride. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 293-304. PMID 20571519 DOI: 10.1038/Jcbfm.2010.91 |
0.305 |
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| 2011 |
Lyon GJ, Abi-Dargham A, Moore H, Lieberman JA, Javitch JA, Sulzer D. Presynaptic regulation of dopamine transmission in schizophrenia. Schizophrenia Bulletin. 37: 108-17. PMID 19525353 DOI: 10.1093/Schbul/Sbp010 |
0.375 |
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| 2011 |
Sibley D, Hazelwood L, Roof R, Free R, Han Y, Javitch J. Membrane lipid rafts are required for D2 dopamine receptor signaling European Psychiatry. 26: 910-910. DOI: 10.1016/S0924-9338(11)72615-3 |
0.32 |
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| 2010 |
Speed NK, Matthies HJ, Kennedy JP, Vaughan RA, Javitch JA, Russo SJ, Lindsley CW, Niswender K, Galli A. Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression. Acs Chemical Neuroscience. 1: 476-81. PMID 22778840 DOI: 10.1021/Cn100031T |
0.397 |
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| 2010 |
Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC. Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (New York, N.Y.). 330: 1091-5. PMID 21097933 DOI: 10.1126/Science.1197410 |
0.476 |
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| 2010 |
Silvano E, Millan MJ, Mannoury la Cour C, Han Y, Duan L, Griffin SA, Luedtke RR, Aloisi G, Rossi M, Zazzeroni F, Javitch JA, Maggio R. The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors. Molecular Pharmacology. 78: 925-34. PMID 20702763 DOI: 10.1124/Mol.110.065755 |
0.443 |
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| 2010 |
Zhang P, Cyriac G, Kopajtic T, Zhao Y, Javitch JA, Katz JL, Newman AH. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of Medicinal Chemistry. 53: 6112-21. PMID 20672825 DOI: 10.1021/Jm1005034 |
0.395 |
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| 2010 |
Gkountelias K, Papadokostaki M, Javitch JA, Liapakis G. Exploring the binding site crevice of a family B G protein-coupled receptor, the type 1 corticotropin releasing factor receptor. Molecular Pharmacology. 78: 785-93. PMID 20664003 DOI: 10.1124/Mol.110.065474 |
0.373 |
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| 2010 |
Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, et al. Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nature Chemical Biology. 6: 587-94. PMID 20622858 DOI: 10.1038/Nchembio.396 |
0.383 |
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| 2010 |
Karam CS, Ballon JS, Bivens NM, Freyberg Z, Girgis RR, Lizardi-Ortiz JE, Markx S, Lieberman JA, Javitch JA. Signaling pathways in schizophrenia: emerging targets and therapeutic strategies. Trends in Pharmacological Sciences. 31: 381-90. PMID 20579747 DOI: 10.1016/J.Tips.2010.05.004 |
0.653 |
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| 2010 |
Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS. Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nature Structural & Molecular Biology. 17: 822-9. PMID 20562855 DOI: 10.1038/Nsmb.1854 |
0.327 |
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| 2010 |
Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, et al. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (Oxford, England). 26: 1804-5. PMID 20501551 DOI: 10.1093/Bioinformatics/Btq264 |
0.319 |
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| 2010 |
Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA. Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature. 465: 188-93. PMID 20463731 DOI: 10.1038/Nature09057 |
0.361 |
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| 2010 |
Bowton E, Saunders C, Erreger K, Sakrikar D, Matthies HJ, Sen N, Jessen T, Colbran RJ, Caron MG, Javitch JA, Blakely RD, Galli A. Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6048-57. PMID 20427663 DOI: 10.1523/Jneurosci.5094-09.2010 |
0.423 |
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| 2010 |
Zhao Y, Quick M, Shi L, Mehler EL, Weinstein H, Javitch JA. Substrate-dependent proton antiport in neurotransmitter:sodium symporters. Nature Chemical Biology. 6: 109-16. PMID 20081826 DOI: 10.1038/Nchembio.284 |
0.331 |
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| 2010 |
Guo N, Guo W, Kralikova M, Jiang M, Schieren I, Narendran R, Slifstein M, Abi-Dargham A, Laruelle M, Javitch JA, Rayport S. Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracers. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 806-17. PMID 19956086 DOI: 10.1038/Npp.2009.189 |
0.45 |
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| 2010 |
Freyberg Z, Ferrando SJ, Javitch JA. Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. The American Journal of Psychiatry. 167: 388-96. PMID 19917593 DOI: 10.1176/Appi.Ajp.2009.08121873 |
0.644 |
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| 2009 |
Namkung Y, Dipace C, Urizar E, Javitch JA, Sibley DR. G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation. The Journal of Biological Chemistry. 284: 34103-15. PMID 19815545 DOI: 10.1074/Jbc.M109.055707 |
0.438 |
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| 2009 |
Sohy D, Yano H, de Nadai P, Urizar E, Guillabert A, Javitch JA, Parmentier M, Springael JY. Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists. The Journal of Biological Chemistry. 284: 31270-9. PMID 19758998 DOI: 10.1074/Jbc.M109.054809 |
0.605 |
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| 2009 |
Gaskill PJ, Calderon TM, Luers AJ, Eugenin EA, Javitch JA, Berman JW. Human immunodeficiency virus (HIV) infection of human macrophages is increased by dopamine: a bridge between HIV-associated neurologic disorders and drug abuse. The American Journal of Pathology. 175: 1148-59. PMID 19661443 DOI: 10.2353/Ajpath.2009.081067 |
0.326 |
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| 2009 |
Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nature Chemical Biology. 5: 688-95. PMID 19648932 DOI: 10.1038/Nchembio.199 |
0.43 |
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| 2009 |
Fontana AC, Sonders MS, Pereira-Junior OS, Knight M, Javitch JA, Rodrigues V, Amara SG, Mortensen OV. Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin. European Journal of Pharmacology. 616: 48-57. PMID 19549517 DOI: 10.1016/J.Ejphar.2009.06.023 |
0.357 |
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| 2009 |
Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N, Przedborski S, Tieu K. The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. 106: 8043-8. PMID 19416912 DOI: 10.1073/Pnas.0900358106 |
0.378 |
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| 2009 |
Namkung Y, Dipace C, Javitch JA, Sibley DR. G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor. The Journal of Biological Chemistry. 284: 15038-51. PMID 19332542 DOI: 10.1074/Jbc.M900388200 |
0.432 |
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| 2009 |
Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA. Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proceedings of the National Academy of Sciences of the United States of America. 106: 5563-8. PMID 19307590 DOI: 10.1073/Pnas.0811322106 |
0.305 |
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| 2009 |
Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin JP, Volkow ND, et al. Building a new conceptual framework for receptor heteromers. Nature Chemical Biology. 5: 131-4. PMID 19219011 DOI: 10.1038/Nchembio0309-131 |
0.338 |
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| 2009 |
Guptaroy B, Zhang M, Bowton E, Binda F, Shi L, Weinstein H, Galli A, Javitch JA, Neubig RR, Gnegy ME. A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation. Molecular Pharmacology. 75: 514-24. PMID 19098122 DOI: 10.1124/Mol.108.048744 |
0.444 |
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| 2009 |
Goodwin JS, Larson GA, Swant J, Sen N, Javitch JA, Zahniser NR, De Felice LJ, Khoshbouei H. Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo. The Journal of Biological Chemistry. 284: 2978-89. PMID 19047053 DOI: 10.1074/Jbc.M805298200 |
0.427 |
|
| 2009 |
Bortolato A, Aburi M, Urizar E, Javitch JA, Filizola M. Modern Molecular Models and Simulations of Opioid Receptor Dimers Biophysical Journal. 96: 677a. DOI: 10.1016/J.Bpj.2008.12.3578 |
0.411 |
|
| 2009 |
Javitch JA. Asymmetrical function of dopamine D2 receptor dimers Biophysical Journal. 96: 373a. DOI: 10.1016/J.Bpj.2008.12.2803 |
0.442 |
|
| 2009 |
Claxton D, Quick M, Shi L, Chung L, Zhao Y, Weinstein H, Javitch JA, Mchaourab HS. Conformational Cycle Of A Bacterial Homolog Of Human Neurotransmitter Sodium Symporters Biophysical Journal. 96: 195a. DOI: 10.1016/J.Bpj.2008.12.1046 |
0.341 |
|
| 2008 |
Guo W, Urizar E, Kralikova M, Mobarec JC, Shi L, Filizola M, Javitch JA. Dopamine D2 receptors form higher order oligomers at physiological expression levels. The Embo Journal. 27: 2293-304. PMID 18668123 DOI: 10.1038/Emboj.2008.153 |
0.755 |
|
| 2008 |
Binda F, Dipace C, Bowton E, Robertson SD, Lute BJ, Fog JU, Zhang M, Sen N, Colbran RJ, Gnegy ME, Gether U, Javitch JA, Erreger K, Galli A. Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Molecular Pharmacology. 74: 1101-8. PMID 18617632 DOI: 10.1124/Mol.108.048447 |
0.441 |
|
| 2008 |
Shi L, Quick M, Zhao Y, Weinstein H, Javitch JA. The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Molecular Cell. 30: 667-77. PMID 18570870 DOI: 10.1016/J.Molcel.2008.05.008 |
0.33 |
|
| 2008 |
Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature Neuroscience. 11: 780-9. PMID 18568020 DOI: 10.1038/Nn.2146 |
0.382 |
|
| 2008 |
Lute BJ, Khoshbouei H, Saunders C, Sen N, Lin RZ, Javitch JA, Galli A. PI3K signaling supports amphetamine-induced dopamine efflux. Biochemical and Biophysical Research Communications. 372: 656-61. PMID 18510945 DOI: 10.1016/J.Bbrc.2008.05.091 |
0.429 |
|
| 2008 |
Klewe IV, Nielsen SM, Tarpø L, Urizar E, Dipace C, Javitch JA, Gether U, Egebjerg J, Christensen KV. Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling. Neuropharmacology. 54: 1215-22. PMID 18455202 DOI: 10.1016/J.Neuropharm.2008.03.015 |
0.464 |
|
| 2008 |
Kniazeff J, Shi L, Loland CJ, Javitch JA, Weinstein H, Gether U. An intracellular interaction network regulates conformational transitions in the dopamine transporter. The Journal of Biological Chemistry. 283: 17691-701. PMID 18426798 DOI: 10.1074/Jbc.M800475200 |
0.385 |
|
| 2008 |
Erreger K, Grewer C, Javitch JA, Galli A. Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 976-89. PMID 18216205 DOI: 10.1523/Jneurosci.2796-07.2008 |
0.371 |
|
| 2008 |
Laruelle M, Guo N, Guo W, Jiang M, Schieren I, Abi-Dargham A, Javitch J, Rayport S. Impact of dopamine D2 receptor internalization on binding parameters of D2 PET radiotracers Neuroimage. 41: T36. DOI: 10.1016/J.Neuroimage.2008.04.210 |
0.389 |
|
| 2007 |
Zapata A, Kivell B, Han Y, Javitch JA, Bolan EA, Kuraguntla D, Jaligam V, Oz M, Jayanthi LD, Samuvel DJ, Ramamoorthy S, Shippenberg TS. Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. The Journal of Biological Chemistry. 282: 35842-54. PMID 17923483 DOI: 10.1074/Jbc.M611758200 |
0.502 |
|
| 2007 |
Zomot E, Bendahan A, Quick M, Zhao Y, Javitch JA, Kanner BI. Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature. 449: 726-30. PMID 17704762 DOI: 10.1038/Nature06133 |
0.357 |
|
| 2007 |
Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. Bmc Bioinformatics. 8: 177. PMID 17537266 DOI: 10.1186/1471-2105-8-177 |
0.305 |
|
| 2007 |
Quick M, Javitch JA. Monitoring the function of membrane transport proteins in detergent-solubilized form. Proceedings of the National Academy of Sciences of the United States of America. 104: 3603-8. PMID 17360689 DOI: 10.1073/Pnas.0609573104 |
0.333 |
|
| 2007 |
Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacological Reviews. 59: 5-13. PMID 17329545 DOI: 10.1124/Pr.59.1.5 |
0.355 |
|
| 2007 |
Bolan EA, Kivell B, Jaligam V, Oz M, Jayanthi LD, Han Y, Sen N, Urizar E, Gomes I, Devi LA, Ramamoorthy S, Javitch JA, Zapata A, Shippenberg TS. D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism. Molecular Pharmacology. 71: 1222-32. PMID 17267664 DOI: 10.1124/Mol.106.027763 |
0.409 |
|
| 2007 |
Wei Y, Williams JM, Dipace C, Sung U, Javitch JA, Galli A, Saunders C. Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism. Molecular Pharmacology. 71: 835-42. PMID 17164407 DOI: 10.1124/Mol.106.026351 |
0.392 |
|
| 2007 |
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 320: 1-13. PMID 16803859 DOI: 10.1124/Jpet.106.104463 |
0.421 |
|
| 2006 |
Fog JU, Khoshbouei H, Holy M, Owens WA, Vaegter CB, Sen N, Nikandrova Y, Bowton E, McMahon DG, Colbran RJ, Daws LC, Sitte HH, Javitch JA, Galli A, Gether U. Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron. 51: 417-29. PMID 16908408 DOI: 10.1016/J.Neuron.2006.06.028 |
0.439 |
|
| 2006 |
Beuming T, Shi L, Javitch JA, Weinstein H. A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Molecular Pharmacology. 70: 1630-42. PMID 16880288 DOI: 10.1124/Mol.106.026120 |
0.312 |
|
| 2006 |
Quick M, Yano H, Goldberg NR, Duan L, Beuming T, Shi L, Weinstein H, Javitch JA. State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. The Journal of Biological Chemistry. 281: 26444-54. PMID 16798738 DOI: 10.1074/Jbc.M602438200 |
0.769 |
|
| 2006 |
Shi L, Javitch JA. A role for information collection, management, and integration in structure-function studies of G-protein coupled receptors. Current Pharmaceutical Design. 12: 1771-83. PMID 16712487 DOI: 10.2174/138161206776873707 |
0.312 |
|
| 2006 |
Kahlig KM, Lute BJ, Wei Y, Loland CJ, Gether U, Javitch JA, Galli A. Regulation of dopamine transporter trafficking by intracellular amphetamine. Molecular Pharmacology. 70: 542-8. PMID 16684900 DOI: 10.1124/Mol.106.023952 |
0.453 |
|
| 2006 |
Jiang M, Guo W, Scheiren I, Narendran R, Javitch J, Rayport S, Laruelle M. Agonist-mediated internalization of dopamine D2 receptors does not appear to mediate the decrease in benzamides binding potential observed after dopamine surge Neuroimage. 31. DOI: 10.1016/J.Neuroimage.2006.04.022 |
0.48 |
|
| 2005 |
Guo W, Shi L, Filizola M, Weinstein H, Javitch JA. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proceedings of the National Academy of Sciences of the United States of America. 102: 17495-500. PMID 16301531 DOI: 10.1073/Pnas.0508950102 |
0.402 |
|
| 2005 |
Sen N, Shi L, Beuming T, Weinstein H, Javitch JA. A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding. Neuropharmacology. 49: 780-90. PMID 16216288 DOI: 10.1016/J.Neuropharm.2005.08.014 |
0.397 |
|
| 2005 |
Kniazeff J, Loland CJ, Goldberg N, Quick M, Das S, Sitte HH, Javitch JA, Gether U. Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8. Neuropharmacology. 49: 715-23. PMID 16129457 DOI: 10.1016/J.Neuropharm.2005.07.003 |
0.72 |
|
| 2005 |
Sonders MS, Quick M, Javitch JA. How did the neurotransmitter cross the bilayer? A closer view. Current Opinion in Neurobiology. 15: 296-304. PMID 15919190 DOI: 10.1016/J.Conb.2005.05.009 |
0.318 |
|
| 2005 |
Garcia BG, Wei Y, Moron JA, Lin RZ, Javitch JA, Galli A. Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Molecular Pharmacology. 68: 102-9. PMID 15795321 DOI: 10.1124/Mol.104.009092 |
0.375 |
|
| 2005 |
Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA, Galli A. Amphetamine induces dopamine efflux through a dopamine transporter channel. Proceedings of the National Academy of Sciences of the United States of America. 102: 3495-500. PMID 15728379 DOI: 10.1073/Pnas.0407737102 |
0.406 |
|
| 2004 |
Javitch JA. The ants go marching two by two: oligomeric structure of G-protein-coupled receptors. Molecular Pharmacology. 66: 1077-82. PMID 15319448 DOI: 10.1124/Mol.104.006320 |
0.353 |
|
| 2004 |
Bjerggaard C, Fog JU, Hastrup H, Madsen K, Loland CJ, Javitch JA, Gether U. Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7024-36. PMID 15295038 DOI: 10.1523/Jneurosci.1863-04.2004 |
0.347 |
|
| 2004 |
Gnegy ME, Khoshbouei H, Berg KA, Javitch JA, Clarke WP, Zhang M, Galli A. Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter. Molecular Pharmacology. 66: 137-43. PMID 15213305 DOI: 10.1124/Mol.66.1.137 |
0.398 |
|
| 2004 |
Liapakis G, Chan WC, Papadokostaki M, Javitch JA. Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor. Molecular Pharmacology. 65: 1181-90. PMID 15102946 DOI: 10.1124/Mol.65.5.1181 |
0.348 |
|
| 2004 |
Khoshbouei H, Sen N, Guptaroy B, Johnson L', Lund D, Gnegy ME, Galli A, Javitch JA. N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. Plos Biology. 2: E78. PMID 15024426 DOI: 10.1371/Journal.Pbio.0020078 |
0.417 |
|
| 2004 |
Sitte HH, Farhan H, Javitch JA. Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking. Molecular Interventions. 4: 38-47. PMID 14993475 DOI: 10.1124/Mi.4.1.38 |
0.322 |
|
| 2004 |
Shi L, Javitch JA. The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice. Proceedings of the National Academy of Sciences of the United States of America. 101: 440-5. PMID 14704269 DOI: 10.1073/Pnas.2237265100 |
0.404 |
|
| 2004 |
Kahlig KM, Javitch JA, Galli A. Amphetamine regulation of dopamine transport. Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier. The Journal of Biological Chemistry. 279: 8966-75. PMID 14699142 DOI: 10.1074/Jbc.M303976200 |
0.399 |
|
| 2004 |
Loland CJ, Grånäs C, Javitch JA, Gether U. Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding. The Journal of Biological Chemistry. 279: 3228-38. PMID 14597628 DOI: 10.1074/Jbc.M304755200 |
0.389 |
|
| 2003 |
Goldberg NR, Beuming T, Soyer OS, Goldstein RA, Weinstein H, Javitch JA. Probing conformational changes in neurotransmitter transporters: a structural context. European Journal of Pharmacology. 479: 3-12. PMID 14612133 DOI: 10.1016/J.Ejphar.2003.08.052 |
0.702 |
|
| 2003 |
Hastrup H, Sen N, Javitch JA. The human dopamine transporter forms a tetramer in the plasma membrane: cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs. The Journal of Biological Chemistry. 278: 45045-8. PMID 14519759 DOI: 10.1074/Jbc.C300349200 |
0.35 |
|
| 2003 |
Morón JA, Zakharova I, Ferrer JV, Merrill GA, Hope B, Lafer EM, Lin ZC, Wang JB, Javitch JA, Galli A, Shippenberg TS. Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8480-8. PMID 13679416 DOI: 10.1523/Jneurosci.23-24-08480.2003 |
0.761 |
|
| 2003 |
Park S, Geddes TJ, Javitch JA, Kuhn DM. Dopamine prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide: is nitrotyrosine formation an early step in dopamine neuronal damage? The Journal of Biological Chemistry. 278: 28736-42. PMID 12771134 DOI: 10.1074/Jbc.M304362200 |
0.386 |
|
| 2003 |
Androutsellis-Theotokis A, Goldberg NR, Ueda K, Beppu T, Beckman ML, Das S, Javitch JA, Rudnick G. Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters. The Journal of Biological Chemistry. 278: 12703-9. PMID 12569103 DOI: 10.1074/Jbc.M206563200 |
0.693 |
|
| 2003 |
Khoshbouei H, Wang H, Lechleiter JD, Javitch JA, Galli A. Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism. The Journal of Biological Chemistry. 278: 12070-7. PMID 12556446 DOI: 10.1074/Jbc.M212815200 |
0.419 |
|
| 2003 |
Guo W, Shi L, Javitch JA. The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. The Journal of Biological Chemistry. 278: 4385-8. PMID 12496294 DOI: 10.1074/Jbc.C200679200 |
0.425 |
|
| 2003 |
Granas C, Ferrer J, Loland CJ, Javitch JA, Gether U. N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization. The Journal of Biological Chemistry. 278: 4990-5000. PMID 12464618 DOI: 10.1074/Jbc.M205058200 |
0.761 |
|
| 2002 |
Shi L, Liapakis G, Xu R, Guarnieri F, Ballesteros JA, Javitch JA. Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. The Journal of Biological Chemistry. 277: 40989-96. PMID 12167654 DOI: 10.1074/Jbc.M206801200 |
0.376 |
|
| 2002 |
Norgaard-Nielsen K, Norregaard L, Hastrup H, Javitch JA, Gether U. Zn(2+) site engineering at the oligomeric interface of the dopamine transporter. Febs Letters. 524: 87-91. PMID 12135746 DOI: 10.1016/S0014-5793(02)03008-9 |
0.417 |
|
| 2002 |
Carvelli L, Morón JA, Kahlig KM, Ferrer JV, Sen N, Lechleiter JD, Leeb-Lundberg LM, Merrill G, Lafer EM, Ballou LM, Shippenberg TS, Javitch JA, Lin RZ, Galli A. PI 3-kinase regulation of dopamine uptake. Journal of Neurochemistry. 81: 859-69. PMID 12065645 DOI: 10.1046/J.1471-4159.2002.00892.X |
0.765 |
|
| 2002 |
Park SU, Ferrer JV, Javitch JA, Kuhn DM. Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4399-405. PMID 12040046 DOI: 10.1523/Jneurosci.22-11-04399.2002 |
0.762 |
|
| 2002 |
Daws LC, Callaghan PD, Morón JA, Kahlig KM, Shippenberg TS, Javitch JA, Galli A. Cocaine increases dopamine uptake and cell surface expression of dopamine transporters. Biochemical and Biophysical Research Communications. 290: 1545-50. PMID 11820798 DOI: 10.1006/Bbrc.2002.6384 |
0.395 |
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| 2002 |
Shi L, Javitch JA. The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop. Annual Review of Pharmacology and Toxicology. 42: 437-67. PMID 11807179 DOI: 10.1146/Annurev.Pharmtox.42.091101.144224 |
0.382 |
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| 2002 |
Javitch JA, Shi L, Liapakis G. Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors. Methods in Enzymology. 343: 137-56. PMID 11665562 DOI: 10.1016/S0076-6879(02)43131-X |
0.381 |
|
| 2001 |
Liapakis G, Simpson MM, Javitch JA. The substituted-cysteine accessibility method (SCAM) to elucidate membrane protein structure. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 4.15. PMID 18428478 DOI: 10.1002/0471142301.Ns0415S08 |
0.333 |
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| 2001 |
Shi L, Simpson MM, Ballesteros JA, Javitch JA. The first transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle. Biochemistry. 40: 12339-48. PMID 11591153 DOI: 10.1021/Bi011204A |
0.431 |
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| 2001 |
Hastrup H, Karlin A, Javitch JA. Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment. Proceedings of the National Academy of Sciences of the United States of America. 98: 10055-60. PMID 11526230 DOI: 10.1073/Pnas.181344298 |
0.594 |
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| 2001 |
Xu W, Li J, Chen C, Huang P, Weinstein H, Javitch JA, Shi L, de Riel JK, Liu-Chen LY. Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors. Biochemistry. 40: 8018-29. PMID 11434771 DOI: 10.1021/Bi002490D |
0.414 |
|
| 2001 |
Newman AH, Zou MF, Ferrer JV, Javitch JA. [3H]MFZ 2-12: a novel radioligand for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 11: 1659-61. PMID 11425531 DOI: 10.1016/S0960-894X(01)00271-2 |
0.746 |
|
| 2001 |
Ballesteros JA, Shi L, Javitch JA. Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors. Molecular Pharmacology. 60: 1-19. PMID 11408595 DOI: 10.1124/Mol.60.1.1 |
0.378 |
|
| 2001 |
Reith ME, Berfield JL, Wang LC, Ferrer JV, Javitch JA. The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter. The Journal of Biological Chemistry. 276: 29012-8. PMID 11395483 DOI: 10.1074/Jbc.M011785200 |
0.741 |
|
| 2001 |
Ballesteros JA, Jensen AD, Liapakis G, Rasmussen SG, Shi L, Gether U, Javitch JA. Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. The Journal of Biological Chemistry. 276: 29171-7. PMID 11375997 DOI: 10.1074/Jbc.M103747200 |
0.38 |
|
| 2001 |
Wilson J, Lin H, Fu D, Javitch JA, Strange PG. Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation. Journal of Neurochemistry. 77: 493-504. PMID 11299312 DOI: 10.1046/J.1471-4159.2001.00233.X |
0.471 |
|
| 2001 |
Whitehead RE, Ferrer JV, Javitch JA, Justice JB. Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter. Journal of Neurochemistry. 76: 1242-51. PMID 11181843 DOI: 10.1046/J.1471-4159.2001.00125.X |
0.738 |
|
| 2000 |
Liapakis G, Ballesteros JA, Papachristou S, Chan WC, Chen X, Javitch JA. The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor. The Journal of Biological Chemistry. 275: 37779-88. PMID 10964911 DOI: 10.1074/Jbc.M002092200 |
0.374 |
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| 2000 |
Saunders C, Ferrer JV, Shi L, Chen J, Merrill G, Lamb ME, Leeb-Lundberg LM, Carvelli L, Javitch JA, Galli A. Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proceedings of the National Academy of Sciences of the United States of America. 97: 6850-5. PMID 10823899 DOI: 10.1073/Pnas.110035297 |
0.764 |
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| 2000 |
Chen N, Ferrer JV, Javitch JA, Justice JB. Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter. The Journal of Biological Chemistry. 275: 1608-14. PMID 10636852 DOI: 10.1074/Jbc.275.3.1608 |
0.749 |
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| 1999 |
Simpson MM, Ballesteros JA, Chiappa V, Chen J, Suehiro M, Hartman DS, Godel T, Snyder LA, Sakmar TP, Javitch JA. Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments. Molecular Pharmacology. 56: 1116-26. PMID 10570038 DOI: 10.1124/Mol.56.6.1116 |
0.401 |
|
| 1999 |
Marjamäki A, Frang H, Pihlavisto M, Hoffrén AM, Salminen T, Johnson MS, Kallio J, Javitch JA, Scheinin M. Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor. The Journal of Biological Chemistry. 274: 21867-72. PMID 10419505 DOI: 10.1074/Jbc.274.31.21867 |
0.353 |
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| 1999 |
Javitch JA, Ballesteros JA, Chen J, Chiappa V, Simpson MM. Electrostatic and aromatic microdomains within the binding-site crevice of the D2 receptor: contributions of the second membrane-spanning segment. Biochemistry. 38: 7961-8. PMID 10387039 DOI: 10.1021/Bi9905314 |
0.374 |
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| 1999 |
Rasmussen SG, Jensen AD, Liapakis G, Ghanouni P, Javitch JA, Gether U. Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6. Molecular Pharmacology. 56: 175-84. PMID 10385699 DOI: 10.1124/Mol.56.1.175 |
0.391 |
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| 1998 |
Javitch JA. Probing structure of neurotransmitter transporters by substituted-cysteine accessibility method. Methods in Enzymology. 296: 331-46. PMID 9779459 DOI: 10.1016/S0076-6879(98)96025-6 |
0.38 |
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| 1998 |
Ferrer JV, Javitch JA. Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. 95: 9238-43. PMID 9689064 DOI: 10.1073/Pnas.95.16.9238 |
0.75 |
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| 1998 |
Javitch JA, Ballesteros JA, Weinstein H, Chen J. A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice. Biochemistry. 37: 998-1006. PMID 9454590 DOI: 10.1021/Bi972241Y |
0.383 |
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| 1998 |
Javitch JA. Mapping the binding-site crevice of the D2 receptor. Advances in Pharmacology (San Diego, Calif.). 42: 412-5. PMID 9327927 DOI: 10.1016/S1054-3589(08)60776-0 |
0.405 |
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| 1997 |
Javitch JA, Fu D, Liapakis G, Chen J. Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment. The Journal of Biological Chemistry. 272: 18546-9. PMID 9228019 DOI: 10.1074/Jbc.272.30.18546 |
0.378 |
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| 1996 |
Fu D, Ballesteros JA, Weinstein H, Chen J, Javitch JA. Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice. Biochemistry. 35: 11278-85. PMID 8784181 DOI: 10.1021/Bi960928X |
0.403 |
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| 1996 |
Javitch J, Fu D, Chen J. Differentiating dopamine D2 ligands by their sensitivities to modification of Cys118 Biological Psychiatry. 39: 630-631. DOI: 10.1016/0006-3223(96)84386-1 |
0.381 |
|
| 1995 |
Javitch JA, Fu D, Chen J. Residues in the fifth membrane-spanning segment of the dopamine D2 receptor exposed in the binding-site crevice. Biochemistry. 34: 16433-9. PMID 8845371 DOI: 10.1021/Bi00050A026 |
0.369 |
|
| 1995 |
Javitch JA, Fu D, Chen J, Karlin A. Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method. Neuron. 14: 825-31. PMID 7718244 DOI: 10.1016/0896-6273(95)90226-0 |
0.628 |
|
| 1994 |
Javitch JA, Kaback J, Li X, Karlin A. Expression and characterization of human dopamine D2 receptor in baculovirus-infected insect cells. Journal of Receptor Research. 14: 99-117. PMID 8182575 DOI: 10.3109/10799899409066999 |
0.59 |
|
| 1994 |
Javitch JA, Li X, Kaback J, Karlin A. A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice. Proceedings of the National Academy of Sciences of the United States of America. 91: 10355-9. PMID 7937955 DOI: 10.1073/Pnas.91.22.10355 |
0.633 |
|
| 1993 |
Parsons B, Stanley M, Javitch J. Differential visualization of dopamine D2 and D3 receptors in rat brain. European Journal of Pharmacology. 234: 269-72. PMID 8097723 DOI: 10.1016/0014-2999(93)90963-I |
0.394 |
|
| 1985 |
Javitch JA, Strittmatter SM, Snyder SH. Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 1513-21. PMID 4009243 |
0.521 |
|
| 1985 |
Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings of the National Academy of Sciences of the United States of America. 82: 2173-7. PMID 3872460 DOI: 10.1073/Pnas.82.7.2173 |
0.638 |
|
| 1985 |
Uhl GR, Javitch JA, Snyder SH. Normal MPTP binding in parkinsonian substantial nigra: evidence for extraneuronal toxin conversion in human brain. Lancet. 1: 956-7. PMID 2859415 DOI: 10.1016/S0140-6736(85)91729-5 |
0.464 |
|
| 1985 |
Javitch J, Strittmatter S, Snyder S. Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography The Journal of Neuroscience. 5: 1513-1521. DOI: 10.1523/Jneurosci.05-06-01513.1985 |
0.627 |
|
| 1984 |
Javitch JA, Uhl GR, Snyder SH. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: characterization and localization of receptor binding sites in rat and human brain. Proceedings of the National Academy of Sciences of the United States of America. 81: 4591-5. PMID 6611553 DOI: 10.1073/Pnas.81.14.4591 |
0.471 |
|
| 1984 |
Javitch JA, Snyder SH. Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP. European Journal of Pharmacology. 106: 455-6. PMID 6335692 DOI: 10.1016/0014-2999(84)90740-4 |
0.483 |
|
| 1984 |
Strittmatter SM, Lo MM, Javitch JA, Snyder SH. Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway. Proceedings of the National Academy of Sciences of the United States of America. 81: 1599-603. PMID 6324207 DOI: 10.1073/Pnas.81.5.1599 |
0.59 |
|
| 1983 |
Javitch JA, Blaustein RO, Snyder SH. [3H]mazindol binding associated with neuronal dopamine uptake sites in corpus striatum membranes. European Journal of Pharmacology. 90: 461-2. PMID 6884434 DOI: 10.1016/0014-2999(83)90574-5 |
0.486 |
|
| 1983 |
Lee CM, Javitch JA, Snyder SH. Recognition sites for norepinephrine uptake: regulation by neurotransmitter. Science (New York, N.Y.). 220: 626-9. PMID 6301013 DOI: 10.1126/Science.6301013 |
0.434 |
|
| 1982 |
Lee CM, Javitch JA, Snyder SH. Characterization of [3H]desipramine binding associated with neuronal norepinephrine uptake sites in rat brain membranes The Journal of Neuroscience. 2: 1515-1525. DOI: 10.1523/Jneurosci.02-10-01515.1982 |
0.445 |
|
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