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Elias Aizenman, Ph.D. - Publications

1989- Neurobiology University of Pittsburgh, Pittsburgh, PA, United States 
Zinc, Potassium Channels, Apoptosis, Redox, NMDA, TOPA

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gale JR, Hartnett-Scott K, Ross MM, Rosenberg PA, Aizenman E. Copper induces neuron-sparing, ferredoxin 1-independent astrocyte toxicity mediated by oxidative stress. Journal of Neurochemistry. PMID 37702109 DOI: 10.1111/jnc.15961  0.801
2023 Ross MM, Aizenman E. GluA1-Shank3 interaction decreases in response to chronic neuronal depolarization. Neuroscience Letters. 809: 137305. PMID 37210067 DOI: 10.1016/j.neulet.2023.137305  0.809
2023 Ross MM, Hernandez-Espinosa DR, Aizenman E. Neurodevelopmental Consequences of Dietary Zinc Deficiency: A Status Report. Biological Trace Element Research. PMID 36964812 DOI: 10.1007/s12011-023-03630-2  0.762
2023 Hernandez-Espinosa DR, Gale JR, Scrabis MG, Aizenman E. Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity. Journal of Neurochemistry. PMID 36625847 DOI: 10.1111/jnc.15760  0.751
2022 Krall R, Gale JR, Ross MM, Tzounopoulos T, Aizenman E. Intracellular zinc signaling influences NMDA receptor function by enhancing the interaction of ZnT1 with GluN2A. Neuroscience Letters. 136896. PMID 36202195 DOI: 10.1016/j.neulet.2022.136896  0.814
2022 Bogdanovic M, Asraf H, Gottesman N, Sekler I, Aizenman E, Hershfinkel M. The ZIP3 zinc transporter is localized to mossy fiber terminals and is required for kainate-induced degeneration of CA3 neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35169020 DOI: 10.1523/JNEUROSCI.0908-21.2022  0.708
2022 Asraf H, Bogdanovic M, Gottesman N, Sekler I, Aizenman E, Hershfinkel M. SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons. Iscience. 25: 103751. PMID 35118363 DOI: 10.1016/j.isci.2022.103751  0.672
2022 Gottesman N, Asraf H, Bogdanovic M, Sekler I, Tzounopoulos T, Aizenman E, Hershfinkel M. ZnT1 is a neuronal Zn/Ca exchanger. Cell Calcium. 101: 102505. PMID 34871934 DOI: 10.1016/j.ceca.2021.102505  0.794
2021 Gale JR, Kosobucki GJ, Hartnett-Scott KA, Aizenman E. Imprecision in Precision Medicine: Differential Response of a Disease-Linked GluN2A Mutant to NMDA Channel Blockers. Frontiers in Pharmacology. 12: 773455. PMID 34776984 DOI: 10.3389/fphar.2021.773455  0.799
2021 Liu HY, Gale JR, Reynolds IJ, Weiss JH, Aizenman E. The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction. Biomedicines. 9. PMID 33946782 DOI: 10.3390/biomedicines9050489  0.793
2021 Krall RF, Tzounopoulos T, Aizenman E. The Function and Regulation of Zinc in the Brain. Neuroscience. PMID 33460731 DOI: 10.1016/j.neuroscience.2021.01.010  0.793
2020 Krall RF, Moutal A, Phillips MB, Asraf H, Johnson JW, Khanna R, Hershfinkel M, Aizenman E, Tzounopoulos T. Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1. Science Advances. 6. PMID 32937457 DOI: 10.1126/Sciadv.Abb1515  0.797
2020 Schulien AJ, Yeh CY, Orange BN, Pav OJ, Hopkins MP, Moutal A, Khanna R, Sun D, Justice JA, Aizenman E. Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels. Science Advances. 6. PMID 32937450 DOI: 10.1126/Sciadv.Aaz8110  0.794
2020 Yeh CY, Schulien AJ, Molyneaux BJ, Aizenman E. Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection. International Journal of Molecular Sciences. 21. PMID 32854248 DOI: 10.3390/Ijms21176107  0.77
2020 Aizenman E, Loring RH, Reynolds IJ, Rosenberg PA. The Redox Biology of Excitotoxic Processes: The NMDA Receptor, TOPA Quinone, and the Oxidative Liberation of Intracellular Zinc. Frontiers in Neuroscience. 14: 778. PMID 32792905 DOI: 10.3389/Fnins.2020.00778  0.84
2019 XiangWei W, Kannan V, Xu Y, Kosobucki GJ, Schulien AJ, Kusumoto H, Moufawad El Achkar C, Bhattacharya S, Lesca G, Nguyen S, Helbig KL, Cuisset JM, Fenger CD, Marjanovic D, Schuler E, ... ... Aizenman E, et al. Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy. Brain : a Journal of Neurology. PMID 31504254 DOI: 10.1093/Brain/Awz232  0.828
2019 Yeh CY, Ye Z, Moutal A, Gaur S, Henton AM, Kouvaros S, Saloman JL, Hartnett-Scott KA, Tzounopoulos T, Khanna R, Aizenman E, Camacho CJ. Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant. Proceedings of the National Academy of Sciences of the United States of America. PMID 31308225 DOI: 10.1073/Pnas.1903401116  0.765
2018 Justice JA, Manjooran DT, Yeh CY, Hartnett-Scott KA, Schulien AJ, Kosobucki GJ, Mammen S, Palladino MJ, Aizenman E. Molecular neuroprotection induced by zinc-dependent expression of hepatitis C-derived protein NS5A targeting Kv2.1 potassium channels. The Journal of Pharmacology and Experimental Therapeutics. PMID 30190339 DOI: 10.1124/Jpet.118.252338  0.824
2017 Yeh CY, Bulas AM, Moutal A, Saloman JL, Hartnett KA, Anderson CT, Tzounopoulos T, Sun D, Khanna R, Aizenman E. Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28483976 DOI: 10.1523/Jneurosci.3811-16.2017  0.764
2017 Justice JA, Schulien AJ, He K, Hartnett KA, Aizenman E, Shah NH. Disruption of KV2.1 somato-dendritic clusters prevents the apoptogenic increase of potassium currents. Neuroscience. PMID 28461216 DOI: 10.1016/J.Neuroscience.2017.04.034  0.811
2017 Ogden KK, Chen W, Swanger SA, McDaniel MJ, Fan LZ, Hu C, Tankovic A, Kusumoto H, Kosobucki GJ, Schulien AJ, Su Z, Pecha J, Bhattacharya S, Petrovski S, Cohen AE, ... Aizenman E, et al. Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology. Plos Genetics. 13: e1006536. PMID 28095420 DOI: 10.1371/Journal.Pgen.1006536  0.828
2016 Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W, Schulien AJ, Chiavacci R, Tankovic A, Naase C, Brueckner F, von Stülpnagel-Steinbeis C, Hu C, ... ... Aizenman E, et al. GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers. American Journal of Human Genetics. PMID 27616483 DOI: 10.1016/J.Ajhg.2016.07.013  0.815
2016 Kumar M, Reed N, Liu R, Aizenman E, Wipf P, Tzounopoulos T. Synthesis and Evaluation of Potent KCNQ2/3-specific Channel Activators. Molecular Pharmacology. PMID 27005699 DOI: 10.1124/Mol.115.103200  0.696
2016 Schulien AJ, Justice JA, Maio RD, Wills ZP, Shah NH, Aizenman E. Zn(2+) -Induced Ca(2+) release via ryanodine receptors triggers calcineurin-dependent redistribution of cortical neuronal Kv2.1 K(+) channels. The Journal of Physiology. PMID 26939666 DOI: 10.1113/Jp272117  0.834
2015 Clemens K, Yeh CY, Aizenman E. Critical role of Casein kinase 2 in hepatitis C NS5A-mediated inhibition of Kv2.1 K(+) channel function. Neuroscience Letters. 609: 48-52. PMID 26472706 DOI: 10.1016/J.Neulet.2015.10.021  0.393
2015 Ganay T, Asraf H, Aizenman E, Bogdanovic M, Sekler I, Hershfinkel M. Regulation of neuronal pH by the metabotropic Zn(2+) -sensing Gq-coupled receptor, mZnR/GPR39. Journal of Neurochemistry. PMID 26375174 DOI: 10.1111/Jnc.13367  0.709
2015 Hershfinkel M, Ford D, Kelleher S, Aizenman E. Seashells by the zinc shore: a meeting report of the International Society for Zinc Biology, Asilomar, CA 2014. Metallomics : Integrated Biometal Science. 7: 1299-304. PMID 26225429 DOI: 10.1039/C5Mt90029H  0.613
2015 He K, McCord MC, Hartnett KA, Aizenman E. Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels. Plos One. 10: e0129498. PMID 26115091 DOI: 10.1371/Journal.Pone.0129498  0.738
2015 Gilad D, Shorer S, Ketzef M, Friedman A, Sekler I, Aizenman E, Hershfinkel M. Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures. Neurobiology of Disease. PMID 25562657 DOI: 10.1016/J.Nbd.2014.12.020  0.686
2014 McCord MC, Kullmann PH, He K, Hartnett KA, Horn JP, Lotan I, Aizenman E. Syntaxin-binding domain of Kv2.1 is essential for the expression of apoptotic K+ currents. The Journal of Physiology. 592: 3511-21. PMID 24928958 DOI: 10.1113/Jphysiol.2014.276964  0.755
2014 McCord MC, Aizenman E. The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease. Frontiers in Aging Neuroscience. 6: 77. PMID 24860495 DOI: 10.3389/Fnagi.2014.00077  0.695
2014 Shah NH, Schulien AJ, Clemens K, Aizenman TD, Hageman TM, Wills ZP, Aizenman E. Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4326-31. PMID 24647953 DOI: 10.1523/Jneurosci.5184-13.2014  0.819
2014 Shah NH, Aizenman E. Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration. Translational Stroke Research. 5: 38-58. PMID 24323720 DOI: 10.1007/S12975-013-0297-7  0.428
2014 Hara H, Aizenman E. Oxidative stress and neuronal zinc signaling Zinc Signals in Cellular Functions and Disorders. 55-87. DOI: 10.1007/978-4-431-55114-0_4  0.45
2013 McCord MC, Aizenman E. Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents. Proceedings of the National Academy of Sciences of the United States of America. 110: 13988-93. PMID 23918396 DOI: 10.1073/Pnas.1306238110  0.713
2013 Perez-Rosello T, Anderson CT, Schopfer FJ, Zhao Y, Gilad D, Salvatore SR, Freeman BA, Hershfinkel M, Aizenman E, Tzounopoulos T. Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9259-72. PMID 23719795 DOI: 10.1523/Jneurosci.0237-13.2013  0.774
2013 Petr GT, Bakradze E, Frederick NM, Wang J, Armsen W, Aizenman E, Rosenberg PA. Glutamate transporter expression and function in a striatal neuronal model of Huntington's disease. Neurochemistry International. 62: 973-81. PMID 23507328 DOI: 10.1016/J.Neuint.2013.02.026  0.552
2012 Nguyen TD, Wirblich C, Aizenman E, Schnell MJ, Strick PL, Kandler K. Targeted single-neuron infection with rabies virus for transneuronal multisynaptic tracing. Journal of Neuroscience Methods. 209: 367-70. PMID 22749814 DOI: 10.1016/J.Jneumeth.2012.06.019  0.345
2012 Norris CA, He K, Springer MG, Hartnett KA, Horn JP, Aizenman E. Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8865-70. PMID 22745487 DOI: 10.1523/Jneurosci.0937-12.2012  0.687
2012 Saadi RA, He K, Hartnett KA, Kandler K, Hershfinkel M, Aizenman E. SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro. Neuroscience. 210: 38-46. PMID 22441041 DOI: 10.1016/J.Neuroscience.2012.03.001  0.647
2012 Redman P, Knoch M, Aizenman E. A Zinc—Potassium Continuum in Neuronal Apoptosis Free Radical Biology and Medicine. 53: 97-115. DOI: 10.1007/978-1-60327-579-8_6  0.824
2011 Sensi SL, Paoletti P, Koh JY, Aizenman E, Bush AI, Hershfinkel M. The neurophysiology and pathology of brain zinc. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16076-85. PMID 22072659 DOI: 10.1523/Jneurosci.3454-11.2011  0.671
2011 Chorin E, Vinograd O, Fleidervish I, Gilad D, Herrmann S, Sekler I, Aizenman E, Hershfinkel M. Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12916-26. PMID 21900570 DOI: 10.1523/Jneurosci.2205-11.2011  0.726
2011 Hara H, Nakamura Y, Ninomiya M, Mochizuki R, Kamiya T, Aizenman E, Koketsu M, Adachi T. Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives on LPS-induced NO production in microglia. Bioorganic & Medicinal Chemistry. 19: 5559-68. PMID 21856162 DOI: 10.1016/J.Bmc.2011.07.036  0.459
2011 Aras MA, Aizenman E. Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons. Antioxidants & Redox Signaling. 15: 2249-63. PMID 20849376 DOI: 10.1089/Ars.2010.3607  0.678
2010 Aizenman E, McCord MC, Saadi RA, Hartnett KA, He K. Complex role of zinc in methamphetamine toxicity in vitro. Neuroscience. 171: 31-9. PMID 20801194 DOI: 10.1016/J.Neuroscience.2010.08.049  0.767
2010 Hershfinkel M, Aizenman E, Andrews G, Sekler I. Zinc bells rang in Jerusalem! Science Signaling. 3: mr2. PMID 20606213 DOI: 10.1126/Scisignal.3129Mr2  0.643
2010 He K, Aizenman E. ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity. Journal of Neurochemistry. 114: 452-61. PMID 20412391 DOI: 10.1111/J.1471-4159.2010.06762.X  0.577
2009 Aras MA, Saadi RA, Aizenman E. Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia. The European Journal of Neuroscience. 30: 2250-7. PMID 20092568 DOI: 10.1111/J.1460-9568.2009.07026.X  0.679
2009 Redman PT, Hartnett KA, Aras MA, Levitan ES, Aizenman E. Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling. The Journal of Physiology. 587: 4393-404. PMID 19622611 DOI: 10.1113/Jphysiol.2009.176321  0.819
2009 Aras MA, Hara H, Hartnett KA, Kandler K, Aizenman E. Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning. Journal of Neurochemistry. 110: 106-17. PMID 19453299 DOI: 10.1111/J.1471-4159.2009.06106.X  0.737
2009 Hershfinkel M, Kandler K, Knoch ME, Dagan-Rabin M, Aras MA, Abramovitch-Dahan C, Sekler I, Aizenman E. Intracellular zinc inhibits KCC2 transporter activity. Nature Neuroscience. 12: 725-7. PMID 19430470 DOI: 10.1038/Nn.2316  0.812
2009 Eisenman LN, Shu HJ, Wang C, Aizenman E, Covey DF, Zorumski CF, Mennerick S. NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue. The Journal of Physiology. 587: 2937-47. PMID 19403611 DOI: 10.1113/Jphysiol.2009.172700  0.43
2008 Ho Y, Samarasinghe R, Knoch ME, Lewis M, Aizenman E, DeFranco DB. Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death. Molecular Pharmacology. 74: 1141-51. PMID 18635668 DOI: 10.1124/Mol.108.049064  0.807
2008 Aras MA, Hartnett KA, Aizenman E. Assessment of cell viability in primary neuronal cultures. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 7.18. PMID 18633999 DOI: 10.1002/0471142301.Ns0718S44  0.652
2008 Knoch ME, Hartnett KA, Hara H, Kandler K, Aizenman E. Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surge. Glia. 56: 89-96. PMID 17955552 DOI: 10.1002/Glia.20592  0.766
2007 Zhang Y, Aizenman E, DeFranco DB, Rosenberg PA. Intracellular zinc release, 12-lipoxygenase activation and MAPK dependent neuronal and oligodendroglial death. Molecular Medicine (Cambridge, Mass.). 13: 350-5. PMID 17622306 DOI: 10.2119/2007-00042.Zhang  0.633
2007 Redman PT, He K, Hartnett KA, Jefferson BS, Hu L, Rosenberg PA, Levitan ES, Aizenman E. Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1. Proceedings of the National Academy of Sciences of the United States of America. 104: 3568-73. PMID 17360683 DOI: 10.1073/Pnas.0610159104  0.804
2006 Redman PT, Jefferson BS, Ziegler CB, Mortensen OV, Torres GE, Levitan ES, Aizenman E. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. 143: 1-6. PMID 17027171 DOI: 10.1016/J.Neuroscience.2006.08.039  0.808
2006 He K, Huang J, Lagenaur CF, Aizenman E. Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons. The Journal of Pharmacology and Experimental Therapeutics. 317: 1320-9. PMID 16547166 DOI: 10.1124/Jpet.106.103044  0.572
2006 Pal SK, Takimoto K, Aizenman E, Levitan ES. Apoptotic surface delivery of K+ channels. Cell Death and Differentiation. 13: 661-7. PMID 16273079 DOI: 10.1038/Sj.Cdd.4401792  0.724
2005 Aras MA, Aizenman E. Obligatory role of ASK1 in the apoptotic surge of K+ currents. Neuroscience Letters. 387: 136-40. PMID 16006035 DOI: 10.1016/J.Neulet.2005.06.024  0.659
2005 Lee H, Chen CX, Liu YJ, Aizenman E, Kandler K. KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses. The European Journal of Neuroscience. 21: 2593-9. PMID 15932617 DOI: 10.1111/J.1460-9568.2005.04084.X  0.361
2005 Land PW, Aizenman E. Zinc accumulation after target loss: an early event in retrograde degeneration of thalamic neurons. The European Journal of Neuroscience. 21: 647-57. PMID 15733083 DOI: 10.1111/J.1460-9568.2005.03903.X  0.438
2004 Zhang Y, Wang H, Li J, Jimenez DA, Levitan ES, Aizenman E, Rosenberg PA. Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10616-27. PMID 15564577 DOI: 10.1523/Jneurosci.2469-04.2004  0.732
2004 Herin GA, Aizenman E. Amino terminal domain regulation of NMDA receptor function. European Journal of Pharmacology. 500: 101-11. PMID 15464024 DOI: 10.1016/J.Ejphar.2004.07.015  0.826
2004 Hara H, Aizenman E. A molecular technique for detecting the liberation of intracellular zinc in cultured neurons. Journal of Neuroscience Methods. 137: 175-80. PMID 15262058 DOI: 10.1016/J.Jneumeth.2004.02.018  0.597
2004 Lu Y, Li Y, Herin GA, Aizenman E, Epstein PM, Rosenberg PA. Elevation of intracellular cAMP evokes activity-dependent release of adenosine in cultured rat forebrain neurons. The European Journal of Neuroscience. 19: 2669-81. PMID 15147301 DOI: 10.1111/J.0953-816X.2004.03396.X  0.831
2004 Pal S, He K, Aizenman E. Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link? Pflã¼Gers Archiv : European Journal of Physiology. 448: 296-303. PMID 15024658 DOI: 10.1007/S00424-004-1256-7  0.682
2004 Zaks-Makhina E, Kim Y, Aizenman E, Levitan ES. Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast. Molecular Pharmacology. 65: 214-9. PMID 14722253 DOI: 10.1124/Mol.65.1.214  0.602
2003 Pal S, Hartnett KA, Nerbonne JM, Levitan ES, Aizenman E. Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4798-802. PMID 12832499 DOI: 10.1523/Jneurosci.23-12-04798.2003  0.728
2003 Leszkiewicz DN, Aizenman E. Reversible modulation of GABA(A) receptor-mediated currents by light is dependent on the redox state of the receptor. The European Journal of Neuroscience. 17: 2077-83. PMID 12786974 DOI: 10.1046/J.1460-9568.2003.02656.X  0.801
2003 McLaughlin B, Hartnett KA, Erhardt JA, Legos JJ, White RF, Barone FC, Aizenman E. Caspase 3 activation is essential for neuroprotection in preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 100: 715-20. PMID 12522260 DOI: 10.1073/Pnas.0232966100  0.599
2002 Leszkiewicz DN, McLaughlin BA, Aizenman E. Protein kinases and light: unlikely partners in a receptor localization puzzle. Physiology & Behavior. 77: 533-6. PMID 12526995 DOI: 10.1016/S0031-9384(02)00911-3  0.834
2002 Leszkiewicz D, Aizenman E. A role for the redox site in the modulation of the NMDA receptor by light. The Journal of Physiology. 545: 435-40. PMID 12456823 DOI: 10.1113/Jphysiol.2002.032755  0.819
2002 Du S, McLaughlin B, Pal S, Aizenman E. In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7408-16. PMID 12196562 DOI: 10.1523/Jneurosci.22-17-07408.2002  0.671
2002 Legos JJ, McLaughlin B, Skaper SD, Strijbos PJ, Parsons AA, Aizenman E, Herin GA, Barone FC, Erhardt JA. The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury. European Journal of Pharmacology. 447: 37-42. PMID 12106800 DOI: 10.1016/S0014-2999(02)01890-3  0.816
2002 Aizenman E, Sanguinetti MC. Channels gone bad. Reflections from a Tapas bar. Neuron. 34: 679-83. PMID 12062016 DOI: 10.1016/S0896-6273(02)00728-6  0.331
2002 Santos S, Aizenman E. Functional expression of muscle-type nicotinic acetylcholine receptors in rat forebrain neurons in vitro. Methods and Findings in Experimental and Clinical Pharmacology. 24: 63-6. PMID 12040883 DOI: 10.1358/Mf.2002.24.2.677127  0.458
2001 Herin GA, Du S, Aizenman E. The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site. Journal of Neurochemistry. 78: 1307-14. PMID 11579139 DOI: 10.1046/J.1471-4159.2001.00517.X  0.853
2001 McLaughlin B, Pal S, Tran MP, Parsons AA, Barone FC, Erhardt JA, Aizenman E. p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3303-11. PMID 11331359 DOI: 10.1523/Jneurosci.21-10-03303.2001  0.61
2000 Sinor JD, Du S, Venneti S, Blitzblau RC, Leszkiewicz DN, Rosenberg PA, Aizenman E. NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 8831-7. PMID 11102491 DOI: 10.1523/Jneurosci.20-23-08831.2000  0.84
2000 Aizenman E, Sinor JD, Brimecombe JC, Herin GA. Alterations of N-methyl-D-aspartate receptor properties after chemical ischemia. The Journal of Pharmacology and Experimental Therapeutics. 295: 572-7. PMID 11046090  0.838
2000 Aizenman E, Stout AK, Hartnett KA, Dineley KE, McLaughlin B, Reynolds IJ. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. Journal of Neurochemistry. 75: 1878-88. PMID 11032877 DOI: 10.1046/J.1471-4159.2000.0751878.X  0.803
2000 Leszkiewicz DN, Kandler K, Aizenman E. Enhancement of NMDA receptor-mediated currents by light in rat neurones in vitro. The Journal of Physiology. 524: 365-74. PMID 10766918 DOI: 10.1111/J.1469-7793.2000.T01-1-00365.X  0.842
2000 Sanchez RM, Wang C, Gardner G, Orlando L, Tauck DL, Rosenberg PA, Aizenman E, Jensen FE. Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2409-17. PMID 10704515 DOI: 10.1523/Jneurosci.20-06-02409.2000  0.724
2000 Li-Smerin Y, Aizenman E, Johnson JW. Inhibition by intracellular Mg(2+) of recombinant N-methyl-D-aspartate receptors expressed in Chinese hamster ovary cells. The Journal of Pharmacology and Experimental Therapeutics. 292: 1104-10. PMID 10688629  0.42
1999 Brimecombe JC, Potthoff WK, Aizenman E. A critical role of the N-methyl-D-aspartate (NMDA) receptor subunit (NR) 2A in the expression of redox sensitivity of NR1/NR2A recombinant NMDA receptors. The Journal of Pharmacology and Experimental Therapeutics. 291: 785-92. PMID 10525101  0.82
1999 Aizenman E, Potthoff WK. Lack of interaction between nitric oxide and the redox modulatory site of the NMDA receptor. British Journal of Pharmacology. 126: 296-300. PMID 10051148 DOI: 10.1038/Sj.Bjp.0702295  0.516
1998 Aizenman E, Brimecombe JC, Potthoff WK, Rosenberg PA. Why is the role of nitric oxide in NMDA receptor function and dysfunction so controversial? Progress in Brain Research. 118: 53-71. PMID 9932434 DOI: 10.1016/S0079-6123(08)63200-8  0.837
1998 Wang GJ, Chung HJ, Schnuer J, Lea E, Robinson MB, Potthoff WK, Aizenman E, Rosenberg PA. Dihydrokainate-sensitive neuronal glutamate transport is required for protection of rat cortical neurons in culture against synaptically released glutamate. The European Journal of Neuroscience. 10: 2523-31. PMID 9767383 DOI: 10.1046/J.1460-9568.1998.00256.X  0.674
1998 Arden SR, Sinor JD, Potthoff WK, Aizenman E. Subunit-specific interactions of cyanide with the N-methyl-D-aspartate receptor. The Journal of Biological Chemistry. 273: 21505-11. PMID 9705279 DOI: 10.1074/Jbc.273.34.21505  0.836
1998 Brimecombe JC, Gallagher MJ, Lynch DR, Aizenman E. An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors. The Journal of Pharmacology and Experimental Therapeutics. 286: 627-34. PMID 9694913  0.833
1998 Hoyt KR, Arden SR, Aizenman E, Reynolds IJ. Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons. Molecular Pharmacology. 53: 742-9. PMID 9547366 DOI: 10.1124/Mol.53.4.742  0.814
1997 Brimecombe JC, Boeckman FA, Aizenman E. Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors. Proceedings of the National Academy of Sciences of the United States of America. 94: 11019-24. PMID 9380752 DOI: 10.1073/Pnas.94.20.11019  0.821
1997 Scanlon JM, Aizenman E, Reynolds IJ. Effects of pyrroloquinoline quinone on glutamate-induced production of reactive oxygen species in neurons. European Journal of Pharmacology. 326: 67-74. PMID 9178657 DOI: 10.1016/S0014-2999(97)00137-4  0.768
1997 Blanpied TA, Boeckman FA, Aizenman E, Johnson JW. Trapping channel block of NMDA-activated responses by amantadine and memantine. Journal of Neurophysiology. 77: 309-23. PMID 9120573 DOI: 10.1152/Jn.1997.77.1.309  0.844
1997 Hartnett KA, Stout AK, Rajdev S, Rosenberg PA, Reynolds IJ, Aizenman E. NMDA receptor-mediated neurotoxicity: a paradoxical requirement for extracellular Mg2+ in Na+/Ca2+-free solutions in rat cortical neurons in vitro. Journal of Neurochemistry. 68: 1836-45. PMID 9109508 DOI: 10.1046/J.1471-4159.1997.68051836.X  0.819
1997 Sinor JD, Boeckman FA, Aizenman E. Intrinsic redox properties of N-methyl-D-aspartate receptor can determine the developmental expression of excitotoxicity in rat cortical neurons in vitro. Brain Research. 747: 297-303. PMID 9046005 DOI: 10.1016/S0006-8993(96)01237-1  0.848
1996 Boeckman FA, Aizenman E. Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits. The Journal of Pharmacology and Experimental Therapeutics. 279: 515-23. PMID 8930153  0.831
1995 Newcomer TA, Rosenberg PA, Aizenman E. Iron-mediated oxidation of 3,4-dihydroxyphenylalanine to an excitotoxin. Journal of Neurochemistry. 64: 1742-8. PMID 7891103 DOI: 10.1046/J.1471-4159.1995.64041742.X  0.816
1995 Newcomer TA, Rosenberg PA, Aizenman E. TOPA quinone, a kainate-like agonist and excitotoxin is generated by a catecholaminergic cell line. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 3172-7. PMID 7722654 DOI: 10.1523/Jneurosci.15-04-03172.1995  0.8
1995 Aizenman E. Modulation of N-methyl-D-aspartate receptors by hydroxyl radicals in rat cortical neurons in vitro. Neuroscience Letters. 189: 57-9. PMID 7603627 DOI: 10.1016/0304-3940(95)11442-Y  0.438
1994 Boeckman FA, Aizenman E. Stable transfection of the NR1 subunit in Chinese hamster ovary cells fails to produce a functional N-methyl-D-aspartate receptor. Neuroscience Letters. 173: 189-92. PMID 7936412 DOI: 10.1016/0304-3940(94)90180-5  0.822
1994 Speliotes EK, Hartnett KA, Blitzblau RC, Aizenman E, Rosenberg PA. Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA. Journal of Neurochemistry. 63: 879-85. PMID 7914224 DOI: 10.1046/J.1471-4159.1994.63030879.X  0.658
1994 Jensen FE, Gardner GJ, Williams AP, Gallop PM, Aizenman E, Rosenberg PA. The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury. Neuroscience. 62: 399-406. PMID 7830887 DOI: 10.1016/0306-4522(94)90375-1  0.553
1994 Aizenman E, Jensen FE, Gallop PM, Rosenberg PA, Tang LH. Further evidence that pyrroloquinoline quinone interacts with the N-methyl-D-aspartate receptor redox site in rat cortical neurons in vitro. Neuroscience Letters. 168: 189-92. PMID 7518062 DOI: 10.1016/0304-3940(94)90447-2  0.679
1993 Reynolds IJ, Zeleski DM, Rothermund KD, Hartnett KA, Tidwell R, Aizenman E. Studies on the effects of several pentamidine analogues on the NMDA receptor. European Journal of Pharmacology. 244: 175-9. PMID 8432312 DOI: 10.1016/0922-4106(93)90023-3  0.753
1993 Newcomer TA, Palmer AM, Rosenberg PA, Aizenman E. Nonenzymatic conversion of 3,4-dihydroxyphenylalanine to 2,4,5-trihydroxyphenylalanine and 2,4,5-trihydroxyphenylalanine quinone in physiological solutions. Journal of Neurochemistry. 61: 911-20. PMID 8360690 DOI: 10.1111/J.1471-4159.1993.Tb03602.X  0.776
1993 Tang LH, Aizenman E. Long-lasting modification of the N-methyl-D-aspartate receptor channel by a voltage-dependent sulfhydryl redox process. Molecular Pharmacology. 44: 473-8. PMID 8355671  0.386
1993 Tang LH, Aizenman E. Allosteric modulation of the NMDA receptor by dihydrolipoic and lipoic acid in rat cortical neurons in vitro. Neuron. 11: 857-63. PMID 8240809 DOI: 10.1016/0896-6273(93)90115-8  0.518
1993 Tang LH, Aizenman E. The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro. The Journal of Physiology. 465: 303-23. PMID 7693919 DOI: 10.1113/Jphysiol.1993.Sp019678  0.501
1992 Aizenman E, Reynolds IJ. Modulation of NMDA excitotoxicity by redox reagents. Annals of the New York Academy of Sciences. 648: 125-31. PMID 1637042 DOI: 10.1111/J.1749-6632.1992.Tb24530.X  0.735
1992 Reynolds IJ, Aizenman E. Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 970-5. PMID 1532027 DOI: 10.1523/Jneurosci.12-03-00970.1992  0.786
1992 Aizenman E, Hartnett KA. The action of CGS-19755 on the redox enhancement of NMDA toxicity in rat cortical neurons in vitro. Brain Research. 585: 28-34. PMID 1511311 DOI: 10.1016/0006-8993(92)91187-J  0.527
1992 Hoyt KR, Tang LH, Aizenman E, Reynolds IJ. Nitric oxide modulates NMDA-induced increases in intracellular Ca2+ in cultured rat forebrain neurons. Brain Research. 592: 310-6. PMID 1450920 DOI: 10.1016/0006-8993(92)91690-G  0.759
1992 Aizenman E, Boeckman FA, Rosenberg PA. Glutathione prevents 2,4,5-trihydroxyphenylalanine excitotoxicity by maintaining it in a reduced, non-active form. Neuroscience Letters. 144: 233-6. PMID 1436708 DOI: 10.1016/0304-3940(92)90757-X  0.834
1992 Aizenman E, Hartnett KA, Zhong C, Gallop PM, Rosenberg PA. Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl-D-aspartate receptor redox modulatory site. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 2362-9. PMID 1318959 DOI: 10.1523/Jneurosci.12-06-02362.1992  0.686
1991 Schulz DW, Loring RH, Aizenman E, Zigmond RE. Autoradiographic localization of putative nicotinic receptors in the rat brain using 125I-neuronal bungarotoxin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 287-97. PMID 1986068 DOI: 10.1523/Jneurosci.11-01-00287.1991  0.641
1991 Gilbert KR, Aizenman E, Reynolds IJ. Oxidized glutathione modulates N-methyl-D-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons. Neuroscience Letters. 133: 11-4. PMID 1838798 DOI: 10.1016/0304-3940(91)90045-U  0.78
1991 Aizenman E, Tang LH, Reynolds IJ. Effects of nicotinic agonists on the NMDA receptor. Brain Research. 551: 355-7. PMID 1833030 DOI: 10.1016/0006-8993(91)90958-X  0.728
1991 Rosenberg PA, Loring R, Xie Y, Zaleskas V, Aizenman E. 2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin. Proceedings of the National Academy of Sciences of the United States of America. 88: 4865-9. PMID 1675790 DOI: 10.1073/Pnas.88.11.4865  0.758
1991 Sucher NJ, Aizenman E, Lipton SA. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 966-71. PMID 1672708 DOI: 10.1523/Jneurosci.11-04-00966.1991  0.64
1990 Aizenman E, Loring RH, Lipton SA. Blockade of nicotinic responses in rat retinal ganglion cells by neuronal bungarotoxin. Brain Research. 517: 209-14. PMID 2375991 DOI: 10.1016/0006-8993(90)91028-F  0.691
1990 Reynolds IJ, Rush EA, Aizenman E. Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes. British Journal of Pharmacology. 101: 178-82. PMID 2149291 DOI: 10.1111/J.1476-5381.1990.Tb12109.X  0.765
1990 Aizenman E, Hartnett KA, Reynolds IJ. Oxygen free radicals regulate NMDA receptor function via a redox modulatory site. Neuron. 5: 841-6. PMID 2148489 DOI: 10.1016/0896-6273(90)90343-E  0.771
1990 Aizenman E, White WF, Loring RH, Rosenberg PA. A 3,4-dihydroxyphenylalanine oxidation product is a non-N-methyl-D-aspartate glutamatergic agonist in rat cortical neurons. Neuroscience Letters. 116: 168-71. PMID 1979663 DOI: 10.1016/0304-3940(90)90404-W  0.783
1989 Loring RH, Aizenman E, Lipton SA, Zigmond RE. Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 2423-31. PMID 2746336 DOI: 10.1523/Jneurosci.09-07-02423.1989  0.712
1989 Aizenman E, Lipton SA, Loring RH. Selective modulation of NMDA responses by reduction and oxidation. Neuron. 2: 1257-63. PMID 2696504 DOI: 10.1016/0896-6273(89)90310-3  0.778
1989 Aizenman E, Karschin A, Lipton SA. Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro. European Journal of Pharmacology. 174: 9-22. PMID 2575535 DOI: 10.1016/0014-2999(89)90868-6  0.53
1989 Rosenberg PA, Aizenman E. Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex. Neuroscience Letters. 103: 162-8. PMID 2570387 DOI: 10.1016/0304-3940(89)90569-7  0.621
1988 Lipton SA, Frosch MP, Phillips MD, Tauck DL, Aizenman E. Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture. Science (New York, N.Y.). 239: 1293-6. PMID 3344435 DOI: 10.1126/Science.3344435  0.525
1988 Hahn JS, Aizenman E, Lipton SA. Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801. Proceedings of the National Academy of Sciences of the United States of America. 85: 6556-60. PMID 2901101 DOI: 10.1073/Pnas.85.17.6556  0.628
1988 Aizenman E, Frosch MP, Lipton SA. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. The Journal of Physiology. 396: 75-91. PMID 2842491 DOI: 10.1113/Jphysiol.1988.Sp016951  0.587
1988 Karschin A, Aizenman E, Lipton SA. The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2895-906. PMID 2842467 DOI: 10.1523/Jneurosci.08-08-02895.1988  0.631
1987 Lipton SA, Aizenman E, Loring RH. Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells. Pflã¼Gers Archiv : European Journal of Physiology. 410: 37-43. PMID 3684508 DOI: 10.1007/Bf00581893  0.709
1986 Aizenman E, Bierkamper GG, Stanley EF. Botulinum toxin prevents stimulus-induced backfiring produced by neostigmine in the mouse phrenic nerve-diaphragm. The Journal of Physiology. 372: 395-404. PMID 3014126 DOI: 10.1113/Jphysiol.1986.Sp016015  0.776
1985 Millington WR, Aizenman E, Bierkamper GG, Zarbin MA, Kuhar MJ. Axonal transport of alpha-bungarotoxin binding sites in rat sciatic nerve. Brain Research. 340: 269-76. PMID 4027653 DOI: 10.1016/0006-8993(85)90923-0  0.711
1985 Aizenman E, Stanley EF, Bierkamper GG. Axonally transported alpha-bungarotoxin binding sites as a putative mechanism for motor nerve backfiring. Proceedings of the Western Pharmacology Society. 28: 201-4. PMID 2415985  0.74
1984 Bierkamper GG, Aizenman E. Cholinergic agonist and antagonist interactions on the putative nicotinic cholinoceptor of motor neurons. Proceedings of the Western Pharmacology Society. 27: 353-6. PMID 6494174  0.714
1984 Bierkamper GG, Aizenman E, Millington WR. Neuromuscular function and organotin compounds. Neurotoxicology. 5: 245-65. PMID 6095143  0.686
1984 Carlson KE, Price CH, Aizenman E. Selective retrograde axonal transport of free glycine in identified neurons of Aplysia. Cellular and Molecular Neurobiology. 4: 231-47. PMID 6084551 DOI: 10.1007/Bf00733587  0.627
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