Stephen J. Haggarty - Publications

Harvard Medical School, Boston, MA, United States 
neuroplasticity, chromatin, neural stem cells

161 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Bai P, Lan Y, Patnaik D, Wang H, Liu Y, Chen Z, Yuan G, Afshar S, Striar R, Zagaroli JS, Tocci DR, Langan AG, Haggarty SJ, Wang C. Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins. Journal of Medicinal Chemistry. PMID 34549949 DOI: 10.1021/acs.jmedchem.1c01323  1
2021 Cheng C, Reis SA, Adams ET, Fass DM, Angus SP, Stuhlmiller TJ, Richardson J, Olafson H, Wang ET, Patnaik D, Beauchamp RL, Feldman DA, Silva MC, Sur M, Johnson GL, ... ... Haggarty SJ, et al. High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy. Scientific Reports. 11: 17029. PMID 34426604 DOI: 10.1038/s41598-021-96227-5  1
2021 Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, ... ... Haggarty SJ, et al. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell. PMID 34314701 DOI: 10.1016/j.cell.2021.07.003  1
2021 Walczyk Mooradally A, Holborn J, Singh K, Tyler M, Patnaik D, Wesseling H, Brandon NJ, Steen J, Graether SP, Haggarty SJ, Lalonde J. Phosphorylation-Dependent control of arc protein by TNIK. Journal of Neurochemistry. PMID 34077555 DOI: 10.1111/jnc.15440  1
2021 Patnaik D, Pao PC, Zhao WN, Silva MC, Hylton NK, Chindavong PS, Pan L, Tsai LH, Haggarty SJ. Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration. Acs Chemical Neuroscience. PMID 33417763 DOI: 10.1021/acschemneuro.0c00308  1
2020 Silva MC, Haggarty SJ. Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. International Journal of Molecular Sciences. 21. PMID 33255694 DOI: 10.3390/ijms21238948  1
2020 Saundh SL, Patnaik D, Gagné S, Bishop JA, Lipsit S, Amat S, Pujari N, Nambisan AK, Bigsby R, Murphy M, Tsai LH, Haggarty SJ, Leung AK. Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein. Acs Chemical Neuroscience. PMID 33253521 DOI: 10.1021/acschemneuro.0c00380  1
2020 Weninger S, Sperling B, Alexander R, Ivarsson M, Menzies FM, Powchik P, Weber CJ, Altar CA, Crystal RG, Haggarty SJ, Loring J, Bain LJ, Carrillo MC. Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 6: e12090. PMID 33083513 DOI: 10.1002/trc2.12090  0.01
2020 Kovalenko M, Erdin S, Andrew MA, St Claire J, Shaughnessey M, Hubert L, Neto JL, Stortchevoi A, Fass DM, Mouro Pinto R, Haggarty SJ, Wilson JH, Talkowski ME, Wheeler VC. Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice. Elife. 9. PMID 32990597 DOI: 10.7554/eLife.55911  1
2020 Haggarty SJ, Karmacharya R, Perlis RH. Advances toward precision medicine for bipolar disorder: mechanisms & molecules. Molecular Psychiatry. PMID 32636474 DOI: 10.1038/S41380-020-0831-4  1
2020 Silva MC, Nandi GA, Tentarelli S, Gurrell IK, Jamier T, Lucente D, Dickerson BC, Brown DG, Brandon NJ, Haggarty SJ. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nature Communications. 11: 3258. PMID 32591533 DOI: 10.1038/S41467-020-16984-1  1
2020 Pao PC, Patnaik D, Watson LA, Gao F, Pan L, Wang J, Adaikkan C, Penney J, Cam HP, Huang WC, Pantano L, Lee A, Nott A, Phan TX, Gjoneska E, ... ... Haggarty SJ, et al. HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. Nature Communications. 11: 2484. PMID 32424276 DOI: 10.1038/S41467-020-16361-Y  1
2020 Bai P, Lu X, Lan Y, Chen Z, Patnaik D, Fiedler S, Striar R, Haggarty SJ, Wang C. Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins. Nuclear Medicine and Biology. 84: 96-101. PMID 32320910 DOI: 10.1016/J.Nucmedbio.2020.04.003  1
2020 Zhao WN, Tobe BTD, Udeshi ND, Xuan LL, Pernia CD, Zolg DP, Roberts AJ, Mani D, Blumenthal SR, Kurtser I, Patnaik D, Gaisina I, Bishop J, Sheridan SD, Lalonde J, ... ... Haggarty SJ, et al. Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion. Translational Psychiatry. 10: 76. PMID 32094324 DOI: 10.1038/S41398-020-0753-6  1
2020 Zimmerman AJ, Hafez AK, Amoah SK, Rodriguez BA, Dell'Orco M, Lozano E, Hartley BJ, Alural B, Lalonde J, Chander P, Webster MJ, Perlis RH, Brennand KJ, Haggarty SJ, Weick J, et al. A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. Molecular Psychiatry. PMID 31988434 DOI: 10.1038/S41380-020-0653-4  1
2020 Martin P, Wagh V, Reis SA, Erdin S, Beauchamp RL, Shaikh G, Talkowski M, Thiele E, Sheridan SD, Haggarty SJ, Ramesh V. TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling. Molecular Autism. 11: 2. PMID 31921404 DOI: 10.1186/S13229-019-0311-3  1
2019 Zaldivar-Diez J, Li L, Garcia AM, Zhao W, Medina-Menendez C, Haggarty SJ, Gil C, Morales AV, Martínez A. BENZOTHIAZOLE-BASED LRRK2 INHIBITORS AS WNT ENHANCERS AND PROMOTERS OF OLIGODENDROCYTIC FATE. Journal of Medicinal Chemistry. PMID 31825616 DOI: 10.1021/Acs.Jmedchem.9B01752  1
2019 Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF. Response to: X-linked miR-506 family miRNAs promote FMRP expression in mouse spermatogonia. Embo Reports. e49354. PMID 31808609 DOI: 10.15252/Embr.201949354  1
2019 Petcherski A, Chandrachud U, Butz ES, Klein MC, Zhao WN, Reis SA, Haggarty SJ, Ruonala MO, Cotman SL. An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration. Cells. 8. PMID 31783699 DOI: 10.3390/Cells8121531  1
2019 Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, ... ... Haggarty SJ, et al. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. PMID 31631020 DOI: 10.1016/J.Stemcr.2019.09.006  1
2019 Bai P, Wey HY, Patnaik D, Lu X, Lan Y, Rokka J, Stephanie F, Haggarty SJ, Wang C. Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging. Chemical Communications (Cambridge, England). PMID 31599282 DOI: 10.1039/C9Cc06734E  1
2019 Bernard-Gauthier V, Mossine AV, Knight A, Patnaik D, Zhao W, Cheng C, Krishnan HS, Xuan LL, Chindavong PS, Reis SA, Chen JM, Shao X, Stauff J, Arteaga J, Sherman PS, ... ... Haggarty SJ, et al. Structural Basis for Achieving GSK-3 Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery. Journal of Medicinal Chemistry. PMID 31535859 DOI: 10.1021/Acs.Jmedchem.9B01030  1
2019 Moreno-Yruela C, Fass DM, Cheng C, Herz J, Olsen CA, Haggarty SJ. Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression. Acs Chemical Neuroscience. PMID 31330099 DOI: 10.1021/Acschemneuro.9B00281  1
2019 Zhao WN, Hylton NK, Wang J, Chindavong PS, Alural B, Kurtser I, Subramanian A, Mazitschek R, Perlis RH, Haggarty SJ. Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA). Molecular and Cellular Neurosciences. PMID 31202891 DOI: 10.1016/J.Mcn.2019.06.006  1
2019 Read J, Collie IT, Nguyen-McCarty M, Lucaj C, Robinson J, Conway L, Mukherjee J, McCall E, Donohoe G, Flavell E, Peciak K, Warwicker J, Dix C, Van den Hoven BG, Madin A, ... ... Haggarty SJ, et al. Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase. Bioorganic & Medicinal Chemistry Letters. PMID 31153805 DOI: 10.1016/J.Bmcl.2019.05.032  1
2019 Lago SG, Tomasik J, van Rees GF, Steeb H, Cox DA, Rustogi N, Ramsey JM, Bishop JA, Petryshen T, Haggarty SJ, Vázquez-Bourgon J, Papiol S, Suarez-Pinilla P, Crespo-Facorro B, van Beveren NJ, et al. Drug discovery for psychiatric disorders using high-content single-cell screening of signaling network responses ex vivo. Science Advances. 5: eaau9093. PMID 31086815 DOI: 10.1126/Sciadv.Aau9093  0.01
2019 McDermott M, Wang J, Zhao WN, Sheridan SD, Szolovits P, Kohane I, Haggarty SJ, Perlis RH. Deep Learning Benchmarks on L1000 Gene Expression Data. Ieee/Acm Transactions On Computational Biology and Bioinformatics. PMID 30990190 DOI: 10.1109/Tcbb.2019.2910061  1
2019 Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, ... ... Haggarty SJ, et al. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Science Translational Medicine. 11. PMID 30918111 DOI: 10.1126/Scitranslmed.Aat3005  1
2019 Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 8. PMID 30907729 DOI: 10.7554/Elife.45457  1
2019 Silva MC, Haggarty SJ. Human pluripotent stem cell-derived models and drug screening in CNS precision medicine. Annals of the New York Academy of Sciences. PMID 30875083 DOI: 10.1111/Nyas.14012  1
2019 Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang H, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ. Author response: Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models Elife. DOI: 10.7554/Elife.45457.037  1
2019 Weick J, Rodriguez B, Amoah S, DellOrco M, Hafez A, Hartley B, Brennand K, Haggarty S, Perrone-Bizzozero N, Mellios N. Dysregulated In Psychiatric Disorders Circular RNAs Interact With Rna Binding Proteins To Regulate Synaptic Plasticity European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.06.035  1
2019 Weick J, Zimmerman A, Amoah S, Rodriguez B, DellOrco M, Hafez A, Chander P, Alural B, Hartley B, Lalonde J, Chen J, Webster M, Perlis R, Haggarty S, Brennand K, et al. F163. A Psychiatric Disease-Related Circular RNA Controls Neuronal Function and Cognition Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.700  1
2019 Amoah S, Rodriguez B, Yellowhair T, Logothetis C, Floruta C, Alural B, Lelonde J, Sheridan S, Perlis R, Haggarty S, Sellgren C, Weick J, Webster M, Jantzie L, Mellios N. T123. A Psychosis-Altered Glial-Produced miRNA Downregulates Neuronal Gene Expression via Exosomes Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.446  1
2018 Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF. A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1. Embo Reports. PMID 30573526 DOI: 10.15252/Embr.201846566  1
2018 Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, ... ... Haggarty SJ, et al. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. The Journal of Clinical Investigation. PMID 30530989 DOI: 10.1172/Jci123743  1
2018 Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, Grossman M, Van Deerlin VM, Trojanowski JQ, et al. Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nature Medicine. PMID 30510257 DOI: 10.1038/S41591-018-0223-3  1
2018 Lin X, Duan X, Jacobs C, Ullmann J, Chan CY, Chen S, Cheng SH, Zhao WN, Poduri A, Wang X, Haggarty SJ, Shi P. High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology. Nature Communications. 9: 5142. PMID 30510233 DOI: 10.1038/S41467-018-07289-5  1
2018 Garza JC, Qi X, Gjeluci K, Leussis MP, Basu H, Reis SA, Zhao WN, Piguel NH, Penzes P, Haggarty SJ, Martens GJ, Poelmans G, Petryshen TL. Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling. Translational Psychiatry. 8: 135. PMID 30046097 DOI: 10.1038/S41398-018-0182-Y  1
2018 Angus SP, Oblinger JL, Stuhlmiller TJ, DeSouza PA, Beauchamp RL, Witt L, Chen X, Jordan JT, Gilbert TSK, Stemmer-Rachamimov A, Gusella JF, Plotkin SR, Haggarty SJ, Chang LS, Johnson GL, et al. EPH receptor signaling as a novel therapeutic target in NF2-deficient meningioma. Neuro-Oncology. PMID 29982664 DOI: 10.1093/Neuonc/Noy046  1
2018 Zhao WN, Ghosh B, Tyler M, Lalonde J, Joseph NF, Kosaric N, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ. Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory. Acs Chemical Neuroscience. PMID 29932631 DOI: 10.1021/Acschemneuro.8B00116  1
2018 Allaway R, Angus SP, Beauchamp RL, Blakeley JO, Bott M, Burns SS, Carlstedt A, Chang LS, Chen X, Clapp DW, Desouza PA, Erdin S, Fernandez-Valle C, Guinney J, ... ... Haggarty SJ, et al. Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2. Plos One. 13: e0197350. PMID 29897904 DOI: 10.1371/Journal.Pone.0197350  1
2018 Nehme R, Zuccaro E, Ghosh SD, Li C, Sherwood JL, Pietilainen O, Barrett LE, Limone F, Worringer KA, Kommineni S, Zang Y, Cacchiarelli D, Meissner A, Adolfsson R, Haggarty S, et al. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Reports. 23: 2509-2523. PMID 29791859 DOI: 10.1016/J.Celrep.2018.04.066  0.01
2018 Mellios N, Feldman DA, Sheridan SD, Ip JPK, Kwok S, Amoah SK, Rosen B, Rodriguez BA, Crawford B, Swaminathan R, Chou S, Li Y, Ziats M, Ernst C, Jaenisch R, ... Haggarty SJ, et al. Human cerebral organoids reveal deficits in neurogenesis and neuronal migration in MeCP2-deficient neural progenitors. Molecular Psychiatry. 23: 791. PMID 29565043 DOI: 10.1038/Mp.2018.5  1
2017 Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, Gould J, Davis JF, Tubelli AA, Asiedu JK, Lahr DL, Hirschman JE, Liu Z, Donahue M, Julian B, ... ... Haggarty SJ, et al. A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell. 171: 1437-1452.e17. PMID 29195078 DOI: 10.1016/J.Cell.2017.10.049  1
2017 Lalonde J, Reis SA, Sivakumaran S, Holland CS, Wesseling H, Sauld JF, Alural B, Zhao WN, Steen JA, Haggarty SJ. Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability. Nature Communications. 8: 1659. PMID 29162813 DOI: 10.1038/S41467-017-01750-7  1
2017 Strebl MG, Campbell AJ, Zhao WN, Schroeder FA, Riley MM, Chindavong PS, Morin TM, Haggarty SJ, Wagner FF, Ritter T, Hooker JM. HDAC6 Brain Mapping with [(18)F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination. Acs Central Science. 3: 1006-1014. PMID 28979942 DOI: 10.1021/Acscentsci.7B00274  1
2017 Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. The Journal of Biological Chemistry. PMID 28972160 DOI: 10.1074/Jbc.M117.815126  1
2017 Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, ... Haggarty SJ, et al. Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28912154 DOI: 10.1523/Jneurosci.0621-17.2017  1
2017 Hennig KM, Fass DM, Zhao WN, Sheridan SD, Fu T, Erdin S, Stortchevoi A, Lucente D, Cody JD, Sweetser D, Gusella JF, Talkowski ME, Haggarty SJ. WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4. Molecular Neuropsychiatry. 3: 53-71. PMID 28879201 DOI: 10.1159/000475666  1
2017 She A, Kurtser I, Reis SA, Hennig K, Lai J, Lang A, Zhao WN, Mazitschek R, Dickerson BC, Herz J, Haggarty SJ. Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia. Cell Chemical Biology. PMID 28712747 DOI: 10.1016/J.Chembiol.2017.06.010  1
2017 Iaconelli J, Lalonde J, Watmuff B, Liu B, Mazitschek R, Haggarty SJ, Karmacharya R. Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells. Acs Chemical Biology. PMID 28628306 DOI: 10.1021/Acschembio.6B01014  1
2017 Tyler MW, Zaldivar-Diez J, Haggarty SJ. Correction to "Classics in Chemical Neuroscience: Haloperidol". Acs Chemical Neuroscience. PMID 28510417 DOI: 10.1021/Acschemneuro.7B00172  1
2017 Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, ... ... Haggarty SJ, et al. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28500272 DOI: 10.1073/Pnas.1700111114  0.36
2017 Mellios N, Feldman DA, Sheridan SD, Ip JPK, Kwok S, Amoah SK, Rosen B, Rodriguez BA, Crawford B, Swaminathan R, Chou S, Li Y, Ziats M, Ernst C, Jaenisch R, ... Haggarty SJ, et al. MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling. Molecular Psychiatry. PMID 28439102 DOI: 10.1038/Mp.2017.86  1
2017 Tyler MW, Yourish HB, Ionescu DF, Haggarty SJ. Classics in Chemical Neuroscience: Ketamine. Acs Chemical Neuroscience. PMID 28418641 DOI: 10.1021/Acschemneuro.7B00074  1
2017 Hu K, Patnaik D, Collier TL, Lee KN, Gao H, Swoyer MR, Rotstein BH, Krishnan HS, Liang SH, Wang J, Yan Z, Hooker JM, Vasdev N, Haggarty SJ, Ngai MY. Development of [(18)F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging. Acs Medicinal Chemistry Letters. 8: 287-292. PMID 28337318 DOI: 10.1021/Acsmedchemlett.6B00405  1
2017 Tyler MW, Zaldivar-Diez J, Haggarty SJ. Classics in Chemical Neuroscience: Haloperidol. Acs Chemical Neuroscience. PMID 28170220 DOI: 10.1021/Acschemneuro.7B00018  1
2017 Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ. Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. Current Protocols in Human Genetics. 92: 21.8.1-21.8.21. PMID 28075486 DOI: 10.1002/Cphg.33  1
2016 Wang Y, Wach JY, Sheehan P, Zhong C, Zhan C, Harris R, Almo SC, Bishop J, Haggarty SJ, Ramek A, Berry KN, O'Herin C, Koehler AN, Hung AW, Young DW. Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β. Acs Medicinal Chemistry Letters. 7: 852-6. PMID 27660690 DOI: 10.1021/Acsmedchemlett.6B00230  1
2016 Ricq EL, Hooker JM, Haggarty SJ. Activity-Dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch. The Journal of Biological Chemistry. PMID 27634040 DOI: 10.1074/Jbc.M116.734426  1
2016 Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, ... ... Haggarty SJ, et al. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. PMID 27594585 DOI: 10.1016/J.Stemcr.2016.08.001  1
2016 Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Insights into neuroepigenetics through human histone deacetylase PET imaging. Science Translational Medicine. 8: 351ra106. PMID 27510902 DOI: 10.1126/Scitranslmed.Aaf7551  1
2016 Ricq EL, Hooker JM, Haggarty SJ. Toward Development of Epigenetic Drugs for CNS Disorders: Modulating Neuroplasticity via H3K4 Methylation. Psychiatry and Clinical Neurosciences. PMID 27485392 DOI: 10.1111/Pcn.12426  1
2016 Kim MJ, Biag J, Fass DM, Lewis MC, Zhang Q, Fleishman M, Gangwar SP, Machius M, Fromer M, Purcell SM, McCarroll SA, Rudenko G, Premont RT, Scolnick EM, Haggarty SJ. Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. Molecular Psychiatry. PMID 27457813 DOI: 10.1038/Mp.2016.98  1
2016 Wagner FF, Weïwer M, Steinbacher S, Schomburg A, Reinemer P, Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M, Müller P, Jefson MR, Fass DM, ... Haggarty SJ, et al. Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorganic & Medicinal Chemistry. PMID 27377864 DOI: 10.1016/J.Bmc.2016.06.040  1
2016 Liang SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P, Plummer MS, Para KS, Conn EL, Lopresti-Morrow L, Lanyon LF, Cook JM, Richter KE, Nolan CE, ... ... Haggarty SJ, et al. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angewandte Chemie (International Ed. in English). PMID 27355874 DOI: 10.1002/Anie.201603797  1
2016 Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J, Patnaik D, Barker D, Walpita D, Campbell AJ, Nguyen S, Lewis M, Ross L, Weiwer M, An WF, ... ... Haggarty SJ, et al. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-wide Selectivity and their Functional Effects. Acs Chemical Biology. PMID 27128528 DOI: 10.1021/Acschembio.6B00306  1
2016 Alural B, Genc S, Haggarty SJ. Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 27072377 DOI: 10.1016/J.Pnpbp.2016.03.010  1
2016 Karmacharya R, Haggarty SJ. Stem cell models of neuropsychiatric disorders. Molecular and Cellular Neurosciences. PMID 27013423 DOI: 10.1016/J.Mcn.2016.03.007  1
2016 Reis SA, Ghosh B, Hendricks JA, Szantai-Kis DM, Törk L, Ross KN, Lamb J, Read-Button W, Zheng B, Wang H, Salthouse C, Haggarty SJ, Mazitschek R. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nature Chemical Biology. PMID 26974814 DOI: 10.1038/Nchembio.2042  1
2016 Haggarty SJ, Silva MC, Cross A, Brandon NJ, Perlis RH. Advancing Drug Discovery for Neuropsychiatric Disorders Using Patient-Specific Stem Cell Models. Molecular and Cellular Neurosciences. PMID 26826498 DOI: 10.1016/J.Mcn.2016.01.011  1
2016 Ghosh B, Zhao WN, Reis SA, Patnaik D, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ. Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation. Bioorganic & Medicinal Chemistry Letters. PMID 26804233 DOI: 10.1016/J.Bmcl.2016.01.022  1
2015 Beauchamp RL, James MF, DeSouza PA, Wagh V, Zhao WN, Jordan JT, Stemmer-Rachamimov A, Plotkin SR, Gusella JF, Haggarty SJ, Ramesh V. A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas. Oncotarget. 6: 16981-97. PMID 26219339 DOI: 10.18632/Oncotarget.4858  1
2015 Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, Sur M, Haggarty SJ. Noncoding RNAs connect genetic risk factors to the neurodevelopmental basis of bipolar disorder. Molecular Psychiatry. 20: 548. PMID 25921437 DOI: 10.1038/Mp.2015.51  1
2015 Chandrachud U, Walker MW, Simas AM, Heetveld S, Petcherski A, Klein M, Oh H, Wolf P, Zhao WN, Norton S, Haggarty SJ, Lloyd-Evans E, Cotman SL. Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function. The Journal of Biological Chemistry. 290: 14361-80. PMID 25878248 DOI: 10.1074/Jbc.M114.621706  1
2015 Haggarty SJ. Epigenetic diagnostics for neuropsychiatric disorders: Above the genome. Neurology. 84: 1618-9. PMID 25809306 DOI: 10.1212/Wnl.0000000000001505  0.01
2015 Madison JM, Zhou F, Nigam A, Hussain A, Barker DD, Nehme R, van der Ven K, Hsu J, Wolf P, Fleishman M, O'Dushlaine C, Rose S, Chambert K, Lau FH, Ahfeldt T, ... ... Haggarty SJ, et al. Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities. Molecular Psychiatry. 20: 703-17. PMID 25733313 DOI: 10.1038/Mp.2015.7  1
2015 Wagner FF, Zhang YL, Fass DM, Joseph N, Gale JP, Weïwer M, McCarren P, Fisher SL, Kaya T, Zhao WN, Reis SA, Hennig KM, Thomas M, Lemercier BC, Lewis MC, ... ... Haggarty SJ, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chemical Science (Royal Society of Chemistry : 2010). 6: 804-815. PMID 25642316 DOI: 10.1039/C4Sc02130D  1
2015 Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, Sur M, Haggarty SJ. Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder. Molecular Psychiatry. 20: 573-84. PMID 25623948 DOI: 10.1038/Mp.2014.176  1
2015 Iaconelli J, Huang JH, Berkovitch SS, Chattopadhyay S, Mazitschek R, Schreiber SL, Haggarty SJ, Karmacharya R. HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells. Acs Chemical Biology. 10: 883-90. PMID 25546293 DOI: 10.1021/Cb500838R  1
2015 Beauchamp RL, James MF, DeSouza PA, Wagh V, Zhao WN, Jordan JT, Stemmer-Rachamimov A, Plotkin SR, Gusella JF, Haggarty SJ, Ramesh V. A high-throughput kinome screen reveals serum/glucocorticoidregulated kinase 1 as a therapeutic target for NF2-deficient meningiomas Oncotarget. 6: 16981-16997.  1
2014 Sugathan A, Biagioli M, Golzio C, Erdin S, Blumenthal I, Manavalan P, Ragavendran A, Brand H, Lucente D, Miles J, Sheridan SD, Stortchevoi A, Kellis M, Haggarty SJ, Katsanis N, et al. CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors. Proceedings of the National Academy of Sciences of the United States of America. 111: E4468-77. PMID 25294932 DOI: 10.1073/Pnas.1405266111  1
2014 Wang C, Schroeder FA, Wey HY, Borra R, Wagner FF, Reis S, Kim SW, Holson EB, Haggarty SJ, Hooker JM. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. Journal of Medicinal Chemistry. 57: 7999-8009. PMID 25203558 DOI: 10.1021/Jm500872P  1
2014 Schroeder FA, Wang C, Van de Bittner GC, Neelamegam R, Takakura WR, Karunakaran A, Wey HY, Reis SA, Gale J, Zhang YL, Holson EB, Haggarty SJ, Hooker JM. PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. Acs Chemical Neuroscience. 5: 1055-62. PMID 25188794 DOI: 10.1021/Cn500162J  1
2014 Wang JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, Perlis RH. Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. Translational Psychiatry. 4: e428. PMID 25158003 DOI: 10.1038/Tp.2014.72  1
2014 Mellios N, Woodson J, Garcia RI, Crawford B, Sharma J, Sheridan SD, Haggarty SJ, Sur M. β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome. Proceedings of the National Academy of Sciences of the United States of America. 111: 9947-52. PMID 24958851 DOI: 10.1073/Pnas.1309426111  1
2014 Seo YJ, Kang Y, Muench L, Reid A, Caesar S, Jean L, Wagner F, Holson E, Haggarty SJ, Weiss P, King P, Carter P, Volkow ND, Fowler JS, Hooker JM, et al. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. Acs Chemical Neuroscience. 5: 588-96. PMID 24780082 DOI: 10.1021/Cn500021P  1
2014 Wawer MJ, Jaramillo DE, Dan?ík V, Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, Clemons PA. Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles. Journal of Biomolecular Screening. 19: 738-748. PMID 24710340 DOI: 10.1177/1087057114530783  1
2014 Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kähler A, Duncan L, Stahl E, Genovese G, Fernández E, Collins MO, ... ... Haggarty SJ, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 506: 185-90. PMID 24463508 DOI: 10.1038/Nature12975  1
2014 Gräff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun J, Neve RL, Mach RH, ... Haggarty SJ, et al. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell. 156: 261-76. PMID 24439381 DOI: 10.1016/J.Cell.2013.12.020  1
2014 Lojewski X, Staropoli JF, Biswas-Legrand S, Simas AM, Haliw L, Selig MK, Coppel SH, Goss KA, Petcherski A, Chandrachud U, Sheridan SD, Lucente D, Sims KB, Gusella JF, Sondhi D, ... ... Haggarty SJ, et al. Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway. Human Molecular Genetics. 23: 2005-22. PMID 24271013 DOI: 10.1093/Hmg/Ddt596  1
2014 Minami J, Suzuki R, Mazitschek R, Gorgun G, Ghosh B, Cirstea D, Hu Y, Mimura N, Ohguchi H, Cottini F, Jakubikova J, Munshi NC, Haggarty SJ, Richardson PG, Hideshima T, et al. Histone deacetylase 3 as a novel therapeutic target in multiple myeloma. Leukemia. 28: 680-9. PMID 23913134 DOI: 10.1038/Leu.2013.231  1
2014 Haggarty SJ, Perlis RH. Translation: screening for novel therapeutics with disease-relevant cell types derived from human stem cell models. Biological Psychiatry. 75: 952-60. PMID 23876186 DOI: 10.1016/J.Biopsych.2013.05.028  1
2014 Fass DM, Schroeder FA, Perlis RH, Haggarty SJ. Epigenetic mechanisms in mood disorders: targeting neuroplasticity. Neuroscience. 264: 112-30. PMID 23376737 DOI: 10.1016/J.Neuroscience.2013.01.041  1
2014 Haggarty SJ. Wnt Signaling in Dementia Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. 411-420. DOI: 10.1002/9781118444122.ch31  0.01
2014 Haggarty SJ, Singh K, Perlis RH, Karmacharya R. Neuropsychiatric Disease-Associated Genetic Variation in the Wnt Pathway Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. 393-409. DOI: 10.1002/9781118444122.ch30  1
2014 Haggarty SJ, Singh K, Perlis RH, Karmacharya R. Wnt Signaling in Mood and Psychotic Disorders Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. 379-391. DOI: 10.1002/9781118444122.ch29  1
2013 Wang C, Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y, Neelamegam R, Schroeder FA, Holson EB, Haggarty SJ, Hooker JM. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. American Journal of Nuclear Medicine and Molecular Imaging. 4: 29-38. PMID 24380043  1
2013 Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, ... Haggarty SJ, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. Plos One. 8: e71323. PMID 23967191 DOI: 10.1371/Journal.Pone.0071323  1
2013 Schroeder FA, Chonde DB, Riley MM, Moseley CK, Granda ML, Wilson CM, Wagner FF, Zhang YL, Gale J, Holson EB, Haggarty SJ, Hooker JM. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neuroscience Letters. 550: 119-24. PMID 23810801 DOI: 10.1016/J.Neulet.2013.06.016  1
2013 Wang Y, Zhang YL, Hennig K, Gale JP, Hong Y, Cha A, Riley M, Wagner F, Haggarty SJ, Holson E, Hooker J. Class I HDAC imaging using [ (3)H]CI-994 autoradiography. Epigenetics : Official Journal of the Dna Methylation Society. 8: 756-64. PMID 23803584 DOI: 10.4161/Epi.25202  1
2013 Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nature Neuroscience. 16: 434-40. PMID 23475113 DOI: 10.1038/Nn.3354  1
2013 Shah RR, Koniski A, Shinde M, Blythe SA, Fass DM, Haggarty SJ, Palis J, Klein PS. Regulation of primitive hematopoiesis by class I histone deacetylases. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 242: 108-21. PMID 23184530 DOI: 10.1002/Dvdy.23906  1
2013 Rueckert EH, Barker D, Ruderfer D, Bergen SE, O'Dushlaine C, Luce CJ, Sheridan SD, Theriault KM, Chambert K, Moran J, Purcell SM, Madison JM, Haggarty SJ, Sklar P. Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder. Molecular Psychiatry. 18: 922-9. PMID 22850628 DOI: 10.1038/Mp.2012.104  1
2013 Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology. 64: 81-96. PMID 22771460 DOI: 10.1016/J.Neuropharm.2012.06.043  1
2013 Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang Y, Hennig KM, Gale J, Zhao W, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, ... Haggarty SJ, et al. Chromatin immunoprecipitation (ChIP) of nucleus accumbens from Cpd-60 treated mice. Plos One. DOI: 10.1371/Journal.Pone.0071323.G005  1
2013 Nott A, Fass DM, Haggarty SJ, Tsai LH. HDAC Inhibitors as Novel Therapeutics in Aging and Alzheimer's Disease Epigenetic Regulation in the Nervous System. 225-248. DOI: 10.1016/B978-0-12-391494-1.00008-2  1
2012 Talkowski ME, Maussion G, Crapper L, Rosenfeld JA, Blumenthal I, Hanscom C, Chiang C, Lindgren A, Pereira S, Ruderfer D, Diallo AB, Lopez JP, Turecki G, Chen ES, Gigek C, ... ... Haggarty SJ, et al. Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities. American Journal of Human Genetics. 91: 1128-34. PMID 23217328 DOI: 10.1016/J.Ajhg.2012.10.016  1
2012 Zhao WN, Cheng C, Theriault KM, Sheridan SD, Tsai LH, Haggarty SJ. A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors. Journal of Biomolecular Screening. 17: 1252-63. PMID 22923789 DOI: 10.1177/1087057112456876  1
2012 Anguera MC, Sadreyev R, Zhang Z, Szanto A, Payer B, Sheridan SD, Kwok S, Haggarty SJ, Sur M, Alvarez J, Gimelbrant A, Mitalipova M, Kirby JE, Lee JT. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell. 11: 75-90. PMID 22770242 DOI: 10.1016/J.Stem.2012.03.008  1
2012 Neelamegam R, Ricq EL, Malvaez M, Patnaik D, Norton S, Carlin SM, Hill IT, Wood MA, Haggarty SJ, Hooker JM. Brain-penetrant LSD1 inhibitors can block memory consolidation. Acs Chemical Neuroscience. 3: 120-128. PMID 22754608 DOI: 10.1021/Cn200104Y  1
2012 Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature. 483: 222-6. PMID 22388814 DOI: 10.1038/Nature10849  1
2012 Hewitt KJ, Shamis Y, Knight E, Smith A, Maione A, Alt-Holland A, Sheridan SD, Haggarty SJ, Garlick JA. PDGFRβ expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation. Journal of Cell Science. 125: 2276-87. PMID 22344267 DOI: 10.1242/Jcs.099192  1
2011 Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, et al. Advancing drug discovery for schizophrenia. Annals of the New York Academy of Sciences. 1236: 30-43. PMID 22032400 DOI: 10.1111/J.1749-6632.2011.06216.X  1
2011 Shi P, Scott MA, Ghosh B, Wan D, Wissner-Gross Z, Mazitschek R, Haggarty SJ, Yanik MF. Synapse microarray identification of small molecules that enhance synaptogenesis. Nature Communications. 2: 510. PMID 22027590 DOI: 10.1038/Ncomms1518  1
2011 Sheridan SD, Theriault KM, Reis SA, Zhou F, Madison JM, Daheron L, Loring JF, Haggarty SJ. Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. Plos One. 6: e26203. PMID 22022567 DOI: 10.1371/Journal.Pone.0026203  1
2011 Habibi E, Masoudi-Nejad A, Abdolmaleky HM, Haggarty SJ. Emerging roles of epigenetic mechanisms in Parkinson's disease. Functional & Integrative Genomics. 11: 523-37. PMID 21892731 DOI: 10.1007/S10142-011-0246-Z  0.01
2011 Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ. AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chemistry & Biology. 18: 891-906. PMID 21802010 DOI: 10.1016/J.Chembiol.2011.03.017  1
2011 Wilson AJ, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, Schreiber SL, Khabele D. The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biology & Therapy. 12: 484-93. PMID 21738006 DOI: 10.4161/Cbt.12.6.15956  1
2011 Haggarty SJ, Tsai LH. Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiology of Learning and Memory. 96: 41-52. PMID 21545841 DOI: 10.1016/J.Nlm.2011.04.009  1
2011 Reis SA, Thompson MN, Lee JM, Fossale E, Kim HH, Liao JK, Moskowitz MA, Shaw SY, Dong L, Haggarty SJ, MacDonald ME, Seong IS. Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis. Human Molecular Genetics. 20: 2344-55. PMID 21447599 DOI: 10.1093/Hmg/Ddr127  1
2011 Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, ... Haggarty SJ, et al. AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1397-411. PMID 21389981 DOI: 10.1038/Npp.2011.24  1
2010 Fass DM, Shah R, Ghosh B, Hennig K, Norton S, Zhao WN, Reis SA, Klein PS, Mazitschek R, Maglathlin RL, Lewis TA, Haggarty SJ. Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. Acs Medicinal Chemistry Letters. 2: 39-42. PMID 21874153 DOI: 10.1021/Ml1001954  1
2010 Biechele TL, Camp ND, Fass DM, Kulikauskas RM, Robin NC, White BD, Taraska CM, Moore EC, Muster J, Karmacharya R, Haggarty SJ, Chien AJ, Moon RT. Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma. Chemistry & Biology. 17: 1177-82. PMID 21095567 DOI: 10.1016/J.Chembiol.2010.08.012  1
2010 Marcaurelle LA, Comer E, Dandapani S, Duvall JR, Gerard B, Kesavan S, Lee MD, Liu H, Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A, Ryba TD, Suh BC, ... ... Haggarty SJ, et al. An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors. Journal of the American Chemical Society. 132: 16962-76. PMID 21067169 DOI: 10.1021/Ja105119R  1
2010 Samara C, Rohde CB, Gilleland CL, Norton S, Haggarty SJ, Yanik MF. Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration. Proceedings of the National Academy of Sciences of the United States of America. 107: 18342-7. PMID 20937901 DOI: 10.1073/Pnas.1005372107  1
2010 Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, et al. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 12617-22. PMID 20616024 DOI: 10.1073/Pnas.1006774107  1
2010 Kuai L, Wang X, Madison JM, Schreiber SL, Scolnick EM, Haggarty SJ. Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling. Acs Chemical Neuroscience. 1: 325-342. PMID 20495671 DOI: 10.1021/Cn900046A  1
2010 Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. Chemical phylogenetics of histone deacetylases. Nature Chemical Biology. 6: 238-243. PMID 20139990 DOI: 10.1038/Nchembio.313  1
2010 Kokel D, Bryan J, Laggner C, White R, Cheung CY, Mateus R, Healey D, Kim S, Werdich AA, Haggarty SJ, Macrae CA, Shoichet B, Peterson RT. Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nature Chemical Biology. 6: 231-237. PMID 20081854 DOI: 10.1038/Nchembio.307  1
2010 Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, Schier AF. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science (New York, N.Y.). 327: 348-51. PMID 20075256 DOI: 10.1126/Science.1183090  1
2010 Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, et al. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (New York, N.Y.). 327: 213-6. PMID 20056891 DOI: 10.1126/Science.1179438  1
2010 Kilgore M, Miller CA, Fass DM, Hennig KM, Haggarty SJ, Sweatt JD, Rumbaugh G. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 870-80. PMID 20010553 DOI: 10.1038/Npp.2009.197  1
2009 Rohde CB, Gilleland C, Samara C, Norton S, Haggarty S, Yanik MF. Microfluidic in vivo screen identifies compounds enhancing neuronal regeneration. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 5950-2. PMID 19965065 DOI: 10.1109/IEMBS.2009.5334771  1
2009 Covington HE, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, Berton O, Fass DM, Renthal W, Rush AJ, Wu EY, Ghose S, Krishnan V, Russo SJ, Tamminga C, Haggarty SJ, et al. Antidepressant actions of histone deacetylase inhibitors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11451-60. PMID 19759294 DOI: 10.1523/Jneurosci.1758-09.2009  1
2009 James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT. Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Science Signaling. 2: ra25. PMID 19471023 DOI: 10.1126/Scisignal.2000230  1
2009 Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 459: 55-60. PMID 19424149 DOI: 10.1038/Nature07925  1
2009 Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 136: 1017-31. PMID 19303846 DOI: 10.1016/J.Cell.2008.12.044  1
2008 Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, et al. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron. 60: 803-17. PMID 19081376 DOI: 10.1016/J.Neuron.2008.10.015  1
2008 Haggarty SJ, Schreiber SL. Forward Chemical Genetics Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 299-354. DOI: 10.1002/9783527619375.ch6  1
2007 Renthal W, Maze I, Krishnan V, Covington HE, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, et al. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron. 56: 517-29. PMID 17988634 DOI: 10.1016/J.Neuron.2007.09.032  1
2007 Schmitz K, Haggarty SJ, McPherson OM, Clardy J, Koehler AN. Detecting binding interactions using microarrays of natural product extracts. Journal of the American Chemical Society. 129: 11346-7. PMID 17718493 DOI: 10.1021/Ja073965S  0.48
2006 Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, N.Y.). 313: 1929-35. PMID 17008526 DOI: 10.1126/Science.1132939  1
2006 Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL. Revealing complex traits with small molecules and naturally recombinant yeast strains. Chemistry & Biology. 13: 319-27. PMID 16638537 DOI: 10.1016/J.Chembiol.2006.01.010  1
2005 Forman JJ, Clemons PA, Schreiber SL, Haggarty SJ. SpectralNET--an application for spectral graph analysis and visualization. Bmc Bioinformatics. 6: 260. PMID 16236170 DOI: 10.1186/1471-2105-6-260  1
2005 Haggarty SJ. The principle of complementarity: chemical versus biological space. Current Opinion in Chemical Biology. 9: 296-303. PMID 15939332 DOI: 10.1016/J.Cbpa.2005.04.006  0.01
2004 Haggarty SJ, Clemons PA, Wong JC, Schreiber SL. Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors. Combinatorial Chemistry & High Throughput Screening. 7: 669-76. PMID 15578929 DOI: 10.2174/1386207043328319  1
2004 Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proceedings of the National Academy of Sciences of the United States of America. 101: 16594-9. PMID 15539461 DOI: 10.1073/Pnas.0407117101  1
2004 Wagner BK, Haggarty SJ, Clemons PA. Chemical genomics: probing protein function using small molecules. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 4: 313-20. PMID 15462609 DOI: 10.2165/00129785-200404050-00004  1
2003 Haggarty SJ, Koeller KM, Kau TR, Silver PA, Roberge M, Schreiber SL. Small molecule modulation of the human chromatid decatenation checkpoint. Chemistry & Biology. 10: 1267-79. PMID 14700634 DOI: 10.1016/J.Chembiol.2003.11.014  1
2003 Haggarty SJ, Clemons PA, Schreiber SL. Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations. Journal of the American Chemical Society. 125: 10543-5. PMID 12940736 DOI: 10.1021/Ja035413P  1
2003 Koeller KM, Haggarty SJ, Perkins BD, Leykin I, Wong JC, Kao MC, Schreiber SL. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chemistry & Biology. 10: 397-410. PMID 12770822 DOI: 10.1016/S1074-5521(03)00093-0  1
2003 Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chemistry & Biology. 10: 383-96. PMID 12770821 DOI: 10.1016/S1074-5521(03)00095-4  1
2003 Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proceedings of the National Academy of Sciences of the United States of America. 100: 4389-94. PMID 12677000 DOI: 10.1073/Pnas.0430973100  1
2000 Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chemistry & Biology. 7: 275-86. PMID 10780927 DOI: 10.1016/S1074-5521(00)00101-0  1
2000 Haggarty SJ, Ramalho-Santos M. Will cell alliance breed bureaucracy and leave contributors out? Nature. 403: 591. PMID 10688171 DOI: 10.1038/35001228  1
2000 Rotella DP, Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small-molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen Chemtracts. 13: 256-258.  1
1999 Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science (New York, N.Y.). 286: 971-4. PMID 10542155 DOI: 10.1126/Science.286.5441.971  1
1999 Stockwell BR, Haggarty SJ, Schreiber SL. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chemistry & Biology. 6: 71-83. PMID 10021420 DOI: 10.1016/S1074-5521(99)80004-0  1
1998 Roberge M, Berlinck RG, Xu L, Anderson HJ, Lim LY, Curman D, Stringer CM, Friend SH, Davies P, Vincent I, Haggarty SJ, Kelly MT, Britton R, Piers E, Andersen RJ. High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide. Cancer Research. 58: 5701-6. PMID 9865726  1
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