Konrad Beyreuther, Dr.rer.nat.1968 - Publications

Affiliations: 
Molecular Biology University of Heidelberg, Heidelberg, Baden-Württemberg, Germany 
Area:
Alzheimer and other neurodegenerative diseases
Website:
http://www.zmbh.uni-heidelberg.de/Beyreuther/index.html

276 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Rupp C, Beyreuther K, Maurer K, Kins S. A presenilin 1 mutation in the first case of Alzheimer's disease: revisited. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 869-72. PMID 25130656 DOI: 10.1016/j.jalz.2014.06.005  0.96
2011 Masters CL, Beyreuther K. Amyloid-β Production Neurodegeneration: the Molecular Pathology of Dementia and Movement Disorders: Second Edition. 92-96. DOI: 10.1002/9781444341256.ch11  0.96
2009 Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S. APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14534-44. PMID 19923287 DOI: 10.1523/JNEUROSCI.1546-09.2009  0.96
2009 Lv J, Jia H, Jiang Y, Ruan Y, Liu Z, Yue W, Beyreuther K, Tu P, Zhang D. Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro. Acta Physiologica (Oxford, England). 196: 419-25. PMID 19208093 DOI: 10.1111/j.1748-1716.2009.01961.x  0.52
2008 Wun KS, Miles LA, Crespi GA, Wycherley K, Ascher DB, Barnham KJ, Cappai R, Beyreuther K, Masters CL, Parker MW, McKinstry WJ. Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 438-41. PMID 18453721 DOI: 10.1107/S1744309108011718  1
2008 Grimm MO, Grimm HS, Tomic I, Beyreuther K, Hartmann T, Bergmann C. Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels. The Journal of Biological Chemistry. 283: 11302-11. PMID 18308724 DOI: 10.1074/jbc.M801520200  0.4
2008 Miles LA, Wun KS, Crespi GA, Fodero-Tavoletti MT, Galatis D, Bagley CJ, Beyreuther K, Masters CL, Cappai R, McKinstry WJ, Barnham KJ, Parker MW. Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. Journal of Molecular Biology. 377: 181-92. PMID 18237744 DOI: 10.1016/j.jmb.2007.12.036  1
2007 Back S, Haas P, Tschäpe JA, Gruebl T, Kirsch J, Müller U, Beyreuther K, Kins S. beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment. Journal of Neuroscience Research. 85: 2580-90. PMID 17335075 DOI: 10.1002/jnr.21239  0.96
2007 Rusu P, Jansen A, Soba P, Kirsch J, Löwer A, Merdes G, Kuan YH, Jung A, Beyreuther K, Kjaerulff O, Kins S. Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity. The European Journal of Neuroscience. 25: 1079-86. PMID 17331204 DOI: 10.1111/j.1460-9568.2007.05341.x  0.96
2007 Beyreuther K, Biesalski HK, Fernstrom JD, Grimm P, Hammes WP, Heinemann U, Kempski O, Stehle P, Steinhart H, Walker R. Consensus meeting: monosodium glutamate - an update. European Journal of Clinical Nutrition. 61: 304-13. PMID 16957679 DOI: 10.1038/sj.ejcn.1602526  0.96
2006 Kuan YH, Gruebl T, Soba P, Eggert S, Nesic I, Back S, Kirsch J, Beyreuther K, Kins S. PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2. The Journal of Biological Chemistry. 281: 40114-23. PMID 17050537 DOI: 10.1074/jbc.M605407200  0.96
2006 Masters CL, Beyreuther K. Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway. Brain : a Journal of Neurology. 129: 2823-39. PMID 17012295 DOI: 10.1093/brain/awl251  1
2006 Liu Z, Ruan Y, Yue W, Zhu Z, Hartmann T, Beyreuther K, Zhang D. GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons. Neuroscience Letters. 407: 59-63. PMID 16949204 DOI: 10.1016/j.neulet.2006.08.005  0.52
2006 Masters CL, Beyreuther K. Pathways to the discovery of the Abeta amyloid of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 9: 155-61. PMID 16914854  1
2006 Kwak YD, Brannen CL, Qu T, Kim HM, Dong X, Soba P, Majumdar A, Kaplan A, Beyreuther K, Sugaya K. Amyloid precursor protein regulates differentiation of human neural stem cells. Stem Cells and Development. 15: 381-9. PMID 16846375 DOI: 10.1089/scd.2006.15.381  0.96
2006 Barnham KJ, Cappai R, Beyreuther K, Masters CL, Hill AF. Delineating common molecular mechanisms in Alzheimer's and prion diseases. Trends in Biochemical Sciences. 31: 465-72. PMID 16820299 DOI: 10.1016/j.tibs.2006.06.006  0.96
2006 Masters CL, Beyreuther K. Pathways to the discovery of the Aß amyloid of Alzheimer's disease Alzheimer's Disease: a Century of Scientific and Clinical Research. 155-161.  1
2005 Yavich L, Oksman M, Tanila H, Kerokoski P, Hiltunen M, van Groen T, Puoliväli J, Männistö PT, García-Horsman A, MacDonald E, Beyreuther K, Hartmann T, Jäkälä P. Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein. Neurobiology of Disease. 20: 303-13. PMID 16242637 DOI: 10.1016/j.nbd.2005.03.010  0.4
2005 Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Löwer A, Langer A, Merdes G, Paro R, Masters CL, Müller U, Kins S, Beyreuther K. Homo- and heterodimerization of APP family members promotes intercellular adhesion. The Embo Journal. 24: 3624-34. PMID 16193067 DOI: 10.1038/sj.emboj.7600824  0.96
2005 Masters CL, Beyreuther K. The neuropathology of Alzheimer's disease in the year 2005 Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. 433-440. DOI: 10.1017/CBO9780511544873.030  1
2004 Merdes G, Soba P, Loewer A, Bilic MV, Beyreuther K, Paro R. Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. The Embo Journal. 23: 4082-95. PMID 15385958 DOI: 10.1038/sj.emboj.7600413  0.96
2004 Jia H, Jiang Y, Ruan Y, Zhang Y, Ma X, Zhang J, Beyreuther K, Tu P, Zhang D. Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells. Neuroscience Letters. 367: 123-8. PMID 15308312 DOI: 10.1016/j.neulet.2004.05.093  0.52
2004 Barnham KJ, Haeffner F, Ciccotosto GD, Curtain CC, Tew D, Mavros C, Beyreuther K, Carrington D, Masters CL, Cherny RA, Cappai R, Bush AI. Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1427-9. PMID 15231727 DOI: 10.1096/fj.04-1890fje  1
2004 George AJ, Holsinger RM, McLean CA, Laughton KM, Beyreuther K, Evin G, Masters CL, Li QX. APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease. Neurobiology of Disease. 16: 124-32. PMID 15207269 DOI: 10.1016/j.nbd.2004.01.009  0.96
2004 Loewer A, Soba P, Beyreuther K, Paro R, Merdes G. Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development. Embo Reports. 5: 405-11. PMID 15105831 DOI: 10.1038/sj.embor.7400122  0.96
2004 Zha Q, Ruan Y, Hartmann T, Beyreuther K, Zhang D. GM1 ganglioside regulates the proteolysis of amyloid precursor protein. Molecular Psychiatry. 9: 946-52. PMID 15052275 DOI: 10.1038/sj.mp.4001509  0.52
2004 Eggert S, Paliga K, Soba P, Evin G, Masters CL, Weidemann A, Beyreuther K. The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation. The Journal of Biological Chemistry. 279: 18146-56. PMID 14970212 DOI: 10.1074/jbc.M311601200  0.96
2004 White AR, Barnham KJ, Huang X, Voltakis I, Beyreuther K, Masters CL, Cherny RA, Bush AI, Cappai R. Iron inhibits neurotoxicity induced by trace copper and biological reductants. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 269-80. PMID 14758525 DOI: 10.1007/s00775-004-0521-8  1
2004 Fassbender K, Walter S, Kühl S, Landmann R, Ishii K, Bertsch T, Stalder AK, Muehlhauser F, Liu Y, Ulmer AJ, Rivest S, Lentschat A, Gulbins E, Jucker M, Staufenbiel M, ... ... Beyreuther K, et al. The LPS receptor (CD14) links innate immunity with Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 203-5. PMID 14597556 DOI: 10.1096/fj.03-0364fje  0.96
2003 Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, Kiers L, Cherny R, Li QX, Tammer A, Carrington D, Mavros C, Volitakis I, Xilinas M, Ames D, ... ... Beyreuther K, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Archives of Neurology. 60: 1685-91. PMID 14676042 DOI: 10.1001/archneur.60.12.1685  0.96
2003 Schmechel A, Zentgraf H, Scheuermann S, Fritz G, Pipkorn R, Reed J, Beyreuther K, Bayer TA, Multhaup G. Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies. The Journal of Biological Chemistry. 278: 35317-24. PMID 12840025 DOI: 10.1074/jbc.M303547200  0.64
2003 Rutten BP, Wirths O, Van de Berg WD, Lichtenthaler SF, Vehoff J, Steinbusch HW, Korr H, Beyreuther K, Multhaup G, Bayer TA, Schmitz C. No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment. Neurobiology of Disease. 12: 110-20. PMID 12667466 DOI: 10.1016/S0969-9961(02)00015-3  0.64
2003 White AR, Maher F, Brazier MW, Jobling MF, Thyer J, Stewart LR, Thompson A, Gibson R, Masters CL, Multhaup G, Beyreuther K, Barrow CJ, Collins SJ, Cappai R. Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation. Brain Research. 966: 231-44. PMID 12618346 DOI: 10.1016/S0006-8993(02)04173-2  0.96
2003 Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R. Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. The Journal of Biological Chemistry. 278: 17401-7. PMID 12611883 DOI: 10.1074/jbc.M300629200  0.96
2003 Gamliel A, Teicher C, Hartmann T, Beyreuther K, Stein R. Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines. Neuroscience. 117: 19-28. PMID 12605888 DOI: 10.1016/S0306-4522(02)00830-8  0.4
2003 Grimm HS, Beher D, Lichtenthaler SF, Shearman MS, Beyreuther K, Hartmann T. gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta. The Journal of Biological Chemistry. 278: 13077-85. PMID 12556458 DOI: 10.1074/jbc.M210380200  0.52
2003 Sernee MF, Evin G, Culvenor JG, Villadangos JA, Beyreuther K, Masters CL, Cappai R. Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage. European Journal of Biochemistry / Febs. 270: 495-506. PMID 12542699 DOI: 10.1046/j.1432-1033.2003.03405.x  1
2003 Grziwa B, Grimm MO, Masters CL, Beyreuther K, Hartmann T, Lichtenthaler SF. The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted. The Journal of Biological Chemistry. 278: 6803-8. PMID 12454010 DOI: 10.1074/jbc.M210047200  1
2002 Khalil Z, Poliviou H, Maynard CJ, Beyreuther K, Masters CL, Li QX. Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid Abeta protein. Journal of Alzheimer's Disease : Jad. 4: 467-78. PMID 12515898  1
2002 Li QX, Campbell BC, McLean CA, Thyagarajan D, Gai WP, Kapsa RM, Beyreuther K, Masters CL, Culvenor JG. Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects. Journal of Alzheimer's Disease : Jad. 4: 309-15. PMID 12446933  0.96
2002 Maynard CJ, Cappai R, Volitakis I, Cherny RA, White AR, Beyreuther K, Masters CL, Bush AI, Li QX. Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron. The Journal of Biological Chemistry. 277: 44670-6. PMID 12215434 DOI: 10.1074/jbc.M204379200  1
2002 Simons M, Schwärzler F, Lütjohann D, von Bergmann K, Beyreuther K, Dichgans J, Wormstall H, Hartmann T, Schulz JB. Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial. Annals of Neurology. 52: 346-50. PMID 12205648 DOI: 10.1002/ana.10292  0.96
2002 Wirths O, Multhaup G, Czech C, Feldmann N, Blanchard V, Tremp G, Beyreuther K, Pradier L, Bayer TA. Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice. Brain Pathology (Zurich, Switzerland). 12: 275-86. PMID 12146796  0.68
2002 Simons A, Ruppert T, Schmidt C, Schlicksupp A, Pipkorn R, Reed J, Masters CL, White AR, Cappai R, Beyreuther K, Bayer TA, Multhaup G. Evidence for a copper-binding superfamily of the amyloid precursor protein. Biochemistry. 41: 9310-20. PMID 12135352 DOI: 10.1021/bi0258647  0.96
2002 Holsinger RM, McLean CA, Beyreuther K, Masters CL, Evin G. Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Annals of Neurology. 51: 783-6. PMID 12112088 DOI: 10.1002/ana.10208  0.96
2002 Lütjohann D, Brzezinka A, Barth E, Abramowski D, Staufenbiel M, von Bergmann K, Beyreuther K, Multhaup G, Bayer TA. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. Journal of Lipid Research. 43: 1078-85. PMID 12091492 DOI: 10.1194/jlr.M200071-JLR200  0.64
2002 Mok SS, Turner BJ, Beyreuther K, Masters CL, Barrow CJ, Small DH. Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine. European Journal of Biochemistry / Febs. 269: 3014-22. PMID 12071966 DOI: 10.1046/j.1432-1033.2002.02976.x  0.96
2002 Fodero LR, Sáez-Valero J, McLean CA, Martins RN, Beyreuther K, Masters CL, Robertson TA, Small DH. Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition. Journal of Neurochemistry. 81: 441-8. PMID 12065653 DOI: 10.1046/j.1471-4159.2002.00902.x  0.96
2002 Hamilton JA, Whitty G, White AR, Jobling MF, Thompson A, Barrow CJ, Cappai R, Beyreuther K, Masters CL. Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF). Brain Research. 940: 49-54. PMID 12020874 DOI: 10.1016/S0006-8993(02)02589-1  1
2002 Evin G, Smith MJ, Tziotis A, McLean C, Canterford L, Sharples RA, Cappai R, Weidemann A, Beyreuther K, Cotton RG, Masters CL, Culvenor JG. Alternative transcripts of presenilin-1 associated with frontotemporal dementia. Neuroreport. 13: 917-21. PMID 11997713  1
2002 Schönknecht P, Lütjohann D, Pantel J, Bardenheuer H, Hartmann T, von Bergmann K, Beyreuther K, Schröder J. Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls. Neuroscience Letters. 324: 83-5. PMID 11983301 DOI: 10.1016/S0304-3940(02)00164-7  0.4
2002 Evin G, Smith MJ, Tziotis A, McLean C, Canterford L, Sharples RA, Cappai R, Weidemann A, Beyreuther K, Cotton RG, Masters CL, Culvenor JG. Alternative transcripts of presenilin-1 associated with frontotemporal dementia. Neuroreport. 13: 719-23. PMID 11973477  1
2002 Runz H, Rietdorf J, Tomic I, de Bernard M, Beyreuther K, Pepperkok R, Hartmann T. Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1679-89. PMID 11880497  0.4
2002 Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, Baier G, Masters CL, Beyreuther K, Evin G. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry. 41: 2825-35. PMID 11851430 DOI: 10.1021/bi015794o  1
2002 Gamliel A, Teicher C, Michaelson DM, Pradier L, Hartmann T, Beyreuther K, Stein R. Increased expression of presenilin 2 inhibits protein synthesis. Molecular and Cellular Neurosciences. 19: 111-24. PMID 11817902 DOI: 10.1006/mcne.2001.1068  0.4
2002 Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K. The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain. Proceedings of the National Academy of Sciences of the United States of America. 99: 1365-70. PMID 11805291 DOI: 10.1073/pnas.032395699  1
2002 White AR, Multhaup G, Galatis D, McKinstry WJ, Parker MW, Pipkorn R, Beyreuther K, Masters CL, Cappai R. Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 365-76. PMID 11784781  1
2002 Beyreuther K, Biesalski HK, Dingermann T, Kretzschmar H, Multhaup G, Tatzelt J, Wolfram G. Hohenheim Consensus talks on bovine spongiform encephalopathy (BSE) | Hohenheimer konsensusgespräch "BSE" Aktuelle Ernahrungsmedizin. 27: 304-314. DOI: 10.1055/s-2002-34028  0.64
2001 Masters CL, Beyreuther K. Henryk M. Wisniewski and the amyloid theory of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 3: 83-86. PMID 12214076  1
2001 McLean CA, Beyreuther K, Masters CL. Amyloid Abeta levels in Alzheimer's disease - A diagnostic tool and the key to understanding the natural history of Abeta? Journal of Alzheimer's Disease : Jad. 3: 305-312. PMID 12214051  1
2001 Wirths O, Multhaup G, Czech C, Blanchard V, Tremp G, Pradier L, Beyreuther K, Bayer TA. Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neuroscience Letters. 316: 145-8. PMID 11744223 DOI: 10.1016/S0304-3940(01)02399-0  0.68
2001 Nunan J, Shearman MS, Checler F, Cappai R, Evin G, Beyreuther K, Masters CL, Small DH. The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase. European Journal of Biochemistry / Febs. 268: 5329-36. PMID 11606195 DOI: 10.1046/j.0014-2956.2001.02465.x  0.96
2001 Stewart LR, White AR, Jobling MF, Needham BE, Maher F, Thyer J, Beyreuther K, Masters CL, Collins SJ, Cappai R. Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126. Journal of Neuroscience Research. 65: 565-72. PMID 11550224 DOI: 10.1002/jnr.1186  1
2001 Evin G, Sharples RA, Weidemann A, Reinhard FB, Carbone V, Culvenor JG, Holsinger RM, Sernee MF, Beyreuther K, Masters CL. Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease. Biochemistry. 40: 8359-68. PMID 11444983 DOI: 10.1021/bi002770t  1
2001 Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, Beher D, Bayer TA, Beyreuther K, Multhaup G. Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. The Journal of Biological Chemistry. 276: 33923-9. PMID 11438549 DOI: 10.1074/jbc.M105410200  0.64
2001 Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 30: 665-76. PMID 11430801 DOI: 10.1016/S0896-6273(01)00317-8  0.96
2001 Jayasena UL, Gribble SK, McKenzie A, Beyreuther K, Masters CL, Underwood JR. Identification of structural variations in the carboxyl terminus of Alzheimer's disease-associated beta A4[1-42] amyloid using a monoclonal antibody. Clinical and Experimental Immunology. 124: 297-305. PMID 11422208 DOI: 10.1046/j.1365-2249.2001.01209.x  1
2001 Wirths O, Multhaup G, Czech C, Blanchard V, Moussaoui S, Tremp G, Pradier L, Beyreuther K, Bayer TA. Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neuroscience Letters. 306: 116-20. PMID 11403971 DOI: 10.1016/S0304-3940(01)01876-6  0.68
2001 Masters CL, Beyreuther K. The Worster-Drought syndrome and other syndromes of dementia with spastic paraparesis: the paradox of molecular pathology. Journal of Neuropathology and Experimental Neurology. 60: 317-9. PMID 11305866  1
2001 White AR, Guirguis R, Brazier MW, Jobling MF, Hill AF, Beyreuther K, Barrow CJ, Masters CL, Collins SJ, Cappai R. Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons. Neurobiology of Disease. 8: 299-316. PMID 11300725 DOI: 10.1006/nbdi.2001.0386  0.96
2001 Fassbender K, Simons M, Bergmann C, Stroick M, Lutjohann D, Keller P, Runz H, Kuhl S, Bertsch T, von Bergmann K, Hennerici M, Beyreuther K, Hartmann T. Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 98: 5856-61. PMID 11296263 DOI: 10.1073/pnas.081620098  0.4
2001 Curtain CC, Ali F, Volitakis I, Cherny RA, Norton RS, Beyreuther K, Barrow CJ, Masters CL, Bush AI, Barnham KJ. Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. The Journal of Biological Chemistry. 276: 20466-73. PMID 11274207 DOI: 10.1074/jbc.M100175200  1
2001 White AR, Huang X, Jobling MF, Barrow CJ, Beyreuther K, Masters CL, Bush AI, Cappai R. Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. Journal of Neurochemistry. 76: 1509-20. PMID 11238735 DOI: 10.1046/j.1471-4159.2001.00178.x  1
2001 Campbell BC, McLean CA, Culvenor JG, Gai WP, Blumbergs PC, Jäkälä P, Beyreuther K, Masters CL, Li QX. The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease. Journal of Neurochemistry. 76: 87-96. PMID 11145981 DOI: 10.1046/j.1471-4159.2001.00021.x  0.96
2001 Bayer TA, Wirths O, Majtényi K, Hartmann T, Multhaup G, Beyreuther K, Czech C. Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport. Brain Pathology (Zurich, Switzerland). 11: 1-11. PMID 11145195  0.68
2001 McLean CA, Beyreuther K, Masters CL. Amyloid Aβ levels in Alzheimer's disease - A diagnostic tool and the key to understanding the natural history of Aβ? Journal of Alzheimer's Disease. 3: 305-312.  0.96
2000 Weidemann A, Paliga K, Dürrwang U, Reinhard F, Zhang D, Sandbrink R, Evin G, Masters CL, Beyreuther K. Interaction of the Presenilins with the Amyloid Precursor Protein (APP). Methods in Molecular Medicine. 32: 333-44. PMID 21318530 DOI: 10.1385/1-59259-195-7:333  1
2000 Wirths O, Weickert S, Majtenyi K, Havas L, Kahle PJ, Okochi M, Haass C, Multhaup G, Beyreuther K, Bayer TA. Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques. Neuroreport. 11: 3737-41. PMID 11117482  0.64
2000 Schonknecht P, Pantel J, Werle E, Hartmann T, Essig M, Baudendistel K, Beyreuther K, Schroder J. [Cerebrospinal fluid protein tau levels in the differential diagnosis of Alzheimer's disease]. Fortschritte Der Neurologie-Psychiatrie. 68: 439-46. PMID 11103680 DOI: 10.1055/s-2000-7732  0.4
2000 Leloup C, Michaelson DM, Fisher A, Hartmann T, Beyreuther K, Stein R. M1 muscarinic receptors block caspase activation by phosphoinositide 3-kinase- and MAPK/ERK-independent pathways. Cell Death and Differentiation. 7: 825-33. PMID 11042677 DOI: 10.1038/sj.cdd.4400713  0.4
2000 Jensen M, Hartmann T, Engvall B, Wang R, Uljon SN, Sennvik K, Näslund J, Muehlhauser F, Nordstedt C, Beyreuther K, Lannfelt L. Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems. Molecular Medicine (Cambridge, Mass.). 6: 291-302. PMID 10949910  0.96
2000 Cherny RA, Barnham KJ, Lynch T, Volitakis I, Li QX, McLean CA, Multhaup G, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. Journal of Structural Biology. 130: 209-16. PMID 10940226 DOI: 10.1006/jsbi.2000.4285  0.96
2000 Mok SS, Clippingdale AB, Beyreuther K, Masters CL, Barrow CJ, Small DH. A beta peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture. Journal of Neuroscience Research. 61: 449-57. PMID 10931532 DOI: 10.1002/1097-4547(20000815)61:4<449::AID-JNR12>3.0.CO;2-N  0.96
2000 Ishii K, Muelhauser F, Liebl U, Picard M, Kühl S, Penke B, Bayer T, Wiessler M, Hennerici M, Beyreuther K, Hartmann T, Fassbender K. Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 1485-9. PMID 10928982  0.4
2000 Borchardt T, Schmidt C, Camarkis J, Cappai R, Masters CL, Beyreuther K, Multhaup G. Differential effects of zinc on amyloid precursor protein (APP) processing in copper-resistant variants of cultured Chinese hamster ovary cells. Cellular and Molecular Biology (Noisy-Le-Grand, France). 46: 785-95. PMID 10875440  1
2000 Campbell BC, Li QX, Culvenor JG, Jäkälä P, Cappai R, Beyreuther K, Masters CL, McLean CA. Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies. Neurobiology of Disease. 7: 192-200. PMID 10860784 DOI: 10.1006/nbdi.2000.0286  0.96
2000 Smith MJ, Humphrey KE, Cappai R, Beyreuther K, Masters CL, Cotton RG. Correct heteroduplex formation for mutation detection analysis. Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology. 5: 67-73. PMID 10837092 DOI: 10.1054/MODI00500067  1
2000 Emilien G, Beyreuther K, Masters CL, Maloteaux JM. Prospects for pharmacological intervention in Alzheimer disease. Archives of Neurology. 57: 454-9. PMID 10768617  1
2000 Culvenor JG, Evin G, Cooney MA, Wardan H, Sharples RA, Maher F, Reed G, Diehlmann A, Weidemann A, Beyreuther K, Masters CL. Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells. Experimental Cell Research. 255: 192-206. PMID 10694435 DOI: 10.1006/excr.1999.4791  0.96
2000 Postuma RB, He W, Nunan J, Beyreuther K, Masters CL, Barrow CJ, Small DH. Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures. Journal of Neurochemistry. 74: 1122-30. PMID 10693944  0.96
2000 Emilien G, Maloteaux JM, Beyreuther K, Masters CL. Alzheimer disease: mouse models pave the way for therapeutic opportunities. Archives of Neurology. 57: 176-81. PMID 10681074  1
2000 Coulson EJ, Paliga K, Beyreuther K, Masters CL. What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochemistry International. 36: 175-84. PMID 10676850  1
2000 Evin G, Le Brocque D, Culvenor JG, Galatis D, Weidemann A, Beyreuther K, Masters CL, Cappai R. Presenilin I expression in yeast lowers secretion of the amyloid precursor protein. Neuroreport. 11: 405-8. PMID 10674495  1
2000 Hashimoto M, Takenouchi T, Mallory M, Masliah E, Culvenor JG, McLean CA, Campbell BCV, Masters CL, Li QX, Jakala P, Hartmann T, Beyreuther K. The role of NAC in amyloidogenesis in Alzheimer's disease [2] (multiple letters) American Journal of Pathology. 156: 734-736. PMID 10667911  0.96
2000 Kwok JB, Li QX, Hallupp M, Whyte S, Ames D, Beyreuther K, Masters CL, Schofield PR. Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis. Annals of Neurology. 47: 249-53. PMID 10665499 DOI: 10.1002/1531-8249(200002)47:2<249::AID-ANA18>3.0.CO;2-8  0.96
2000 Bergsdorf C, Paliga K, Kreger S, Masters CL, Beyreuther K. Identification of cis-elements regulating exon 15 splicing of the amyloid precursor protein pre-mRNA. The Journal of Biological Chemistry. 275: 2046-56. PMID 10636908  1
2000 Masters CL, Beyreuther K. Genomic neurology. Archives of Neurology. 57: 53. PMID 10634436  1
1999 Small DH, Clarris HL, Williamson TG, Reed G, Key B, Mok SS, Beyreuther K, Masters CL, Nurcombe V. Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 1: 275-85. PMID 12214125  0.96
1999 McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Annals of Neurology. 46: 860-6. PMID 10589538 DOI: 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M  0.96
1999 Bayer TA, Cappai R, Masters CL, Beyreuther K, Multhaup G. It all sticks together--the APP-related family of proteins and Alzheimer's disease. Molecular Psychiatry. 4: 524-8. PMID 10578233  1
1999 Borchardt T, Camakaris J, Cappai R, Masters CL, Beyreuther K, Multhaup G. Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion. The Biochemical Journal. 344: 461-7. PMID 10567229  1
1999 Caswell MD, Mok SS, Henry A, Cappai R, Klug G, Beyreuther K, Masters CL, Small DH. The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons. European Journal of Biochemistry / Febs. 266: 509-16. PMID 10561592 DOI: 10.1046/j.1432-1327.1999.00886.x  0.96
1999 White AR, Collins SJ, Maher F, Jobling MF, Stewart LR, Thyer JM, Beyreuther K, Masters CL, Cappai R. Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity. The American Journal of Pathology. 155: 1723-30. PMID 10550328 DOI: 10.1016/S0002-9440(10)65487-9  1
1999 Li QX, Fuller SJ, Beyreuther K, Masters CL. The amyloid precursor protein of Alzheimer disease in human brain and blood. Journal of Leukocyte Biology. 66: 567-74. PMID 10534110  0.96
1999 White AR, Multhaup G, Maher F, Bellingham S, Camakaris J, Zheng H, Bush AI, Beyreuther K, Masters CL, Cappai R. The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9170-9. PMID 10531420  1
1999 White AR, Reyes R, Mercer JF, Camakaris J, Zheng H, Bush AI, Multhaup G, Beyreuther K, Masters CL, Cappai R. Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice. Brain Research. 842: 439-44. PMID 10526140  1
1999 Culvenor JG, McLean CA, Cutt S, Campbell BC, Maher F, Jäkälä P, Hartmann T, Beyreuther K, Masters CL, Li QX. Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid. The American Journal of Pathology. 155: 1173-81. PMID 10514400  0.96
1999 Bayer TA, Jäkälä P, Hartmann T, Egensperger R, Buslei R, Falkai P, Beyreuther K. Neural expression profile of alpha-synuclein in developing human cortex. Neuroreport. 10: 2799-803. PMID 10511443  0.64
1999 Jobling MF, Stewart LR, White AR, McLean C, Friedhuber A, Maher F, Beyreuther K, Masters CL, Barrow CJ, Collins SJ, Cappai R. The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126. Journal of Neurochemistry. 73: 1557-65. PMID 10501201  1
1999 Ren RF, Lah JJ, Diehlmann A, Kim ES, Hawver DB, Levey AI, Beyreuther K, Flanders KC. Differential effects of transforming growth factor-beta(s) and glial cell line-derived neurotrophic factor on gene expression of presenilin-1 in human post-mitotic neurons and astrocytes. Neuroscience. 93: 1041-9. PMID 10473269 DOI: 10.1016/S0306-4522(99)00215-8  0.96
1999 Bayer TA, Jäkälä P, Hartmann T, Havas L, McLean C, Culvenor JG, Li QX, Masters CL, Falkai P, Beyreuther K. Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores. Neuroscience Letters. 266: 213-6. PMID 10465711  1
1999 Masters CL, Beyreuther K. Amyloid Nomenclature Committee. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 6: 151-2. PMID 10439124  0.96
1999 Cherny RA, Legg JT, McLean CA, Fairlie DP, Huang X, Atwood CS, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. The Journal of Biological Chemistry. 274: 23223-8. PMID 10438495 DOI: 10.1074/jbc.274.33.23223  0.96
1999 Lichtenthaler SF, Multhaup G, Masters CL, Beyreuther K. A novel substrate for analyzing Alzheimer's disease gamma-secretase. Febs Letters. 453: 288-92. PMID 10405162  1
1999 Christie G, Markwell RE, Gray CW, Smith L, Godfrey F, Mansfield F, Wadsworth H, King R, McLaughlin M, Cooper DG, Ward RV, Howlett DR, Hartmann T, Lichtenthaler SF, Beyreuther K, et al. Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome. Journal of Neurochemistry. 73: 195-204. PMID 10386971 DOI: 10.1046/j.1471-4159.1999.0730195.x  0.96
1999 Li QX, Maynard C, Cappai R, McLean CA, Cherny RA, Lynch T, Culvenor JG, Trevaskis J, Tanner JE, Bailey KA, Czech C, Bush AI, Beyreuther K, Masters CL. Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice. Journal of Neurochemistry. 72: 2479-87. PMID 10349858 DOI: 10.1046/j.1471-4159.1999.0722479.x  0.96
1999 Diehlmann A, Ida N, Weggen S, Grünberg J, Haass C, Masters CL, Bayer TA, Beyreuther K. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. Journal of Neuroscience Research. 56: 405-19. PMID 10340748 DOI: 10.1002/(SICI)1097-4547(19990515)56:4<405::AID-JNR8>3.0.CO;2-F  0.96
1999 White AR, Bush AI, Beyreuther K, Masters CL, Cappai R. Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione. Journal of Neurochemistry. 72: 2092-8. PMID 10217289  1
1999 Storey E, Katz M, Brickman Y, Beyreuther K, Masters CL. Amyloid precursor protein of Alzheimer's disease: evidence for a stable, full-length, trans-membrane pool in primary neuronal cultures. The European Journal of Neuroscience. 11: 1779-88. PMID 10215930  1
1999 Jensen M, Schröder J, Blomberg M, Engvall B, Pantel J, Ida N, Basun H, Wahlund LO, Werle E, Jauss M, Beyreuther K, Lannfelt L, Hartmann T. Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression. Annals of Neurology. 45: 504-11. PMID 10211475 DOI: 10.1002/1531-8249(199904)45:4<504::AID-ANA12>3.0.CO;2-9  0.96
1999 Smith MJ, Gardner RJ, Knight MA, Forrest SM, Beyreuther K, Storey E, McLean CA, Cotton RG, Cappal R, Masters CL. Early-onset Alzheimer's disease caused by a novel mutation at codon 219 of the presenilin-1 gene. Neuroreport. 10: 503-7. PMID 10208579  0.96
1999 Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nature Structural Biology. 6: 327-31. PMID 10201399 DOI: 10.1038/7562  1
1999 Beher D, Elle C, Underwood J, Davis JB, Ward R, Karran E, Masters CL, Beyreuther K, Multhaup G. Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain. Journal of Neurochemistry. 72: 1564-73. PMID 10098862  1
1999 Connop BP, Thies RL, Beyreuther K, Ida N, Reiner PB. Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. Journal of Neurochemistry. 72: 1457-65. PMID 10098849 DOI: 10.1046/j.1471-4159.1999.721457.x  0.96
1999 Multhaup G, Hesse L, Borchardt T, Ruppert T, Cappai R, Masters CL, Beyreuther K. Autoxidation of amyloid precursor protein and formation of reactive oxygen species. Advances in Experimental Medicine and Biology. 448: 183-92. PMID 10079826  0.96
1999 Cappai R, Stewart L, Jobling MF, Thyer JM, White AR, Beyreuther K, Collins SJ, Masters CL, Barrow CJ. Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: implications for the mechanism of prion formation. Biochemistry. 38: 3280-4. PMID 10079070 DOI: 10.1021/bi982328z  1
1999 Lichtenthaler SF, Wang R, Grimm H, Uljon SN, Masters CL, Beyreuther K. Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 96: 3053-8. PMID 10077635 DOI: 10.1073/pnas.96.6.3053  0.96
1999 Egensperger R, Weggen S, Ida N, Multhaup G, Schnabel R, Beyreuther K, Bayer TA. Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease. Acta Neuropathologica. 97: 113-8. PMID 9928821 DOI: 10.1007/s004010050963  0.96
1999 Cappai R, Mok SS, Galatis D, Tucker DF, Henry A, Beyreuther K, Small DH, Masters CL. Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth. Febs Letters. 442: 95-8. PMID 9923612 DOI: 10.1016/S0014-5793(98)01635-4  0.96
1998 Zhang D, Ruan Y, Beyreuther K. [Effect of ganglioside GM1 on the metabolism of Alzheimer amyloid beta-protein precursor]. Zhonghua Yi Xue Za Zhi. 78: 179-82. PMID 10923524  0.52
1998 Tesco G, Kim TW, Diehlmann A, Beyreuther K, Tanzi RE. Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. The Journal of Biological Chemistry. 273: 33909-14. PMID 9852041  0.52
1998 Weggen S, Diehlmann A, Buslei R, Beyreuther K, Bayer TA. Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain. Neuroreport. 9: 3279-83. PMID 9831464  0.96
1998 Henry A, Li QX, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Cappai R. Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein. British Journal of Haematology. 103: 402-15. PMID 9827912  1
1998 Fossgreen A, Brückner B, Czech C, Masters CL, Beyreuther K, Paro R. Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype. Proceedings of the National Academy of Sciences of the United States of America. 95: 13703-8. PMID 9811864 DOI: 10.1073/pnas.95.23.13703  0.96
1998 Le Brocque D, Henry A, Cappai R, Li QX, Tanner JE, Galatis D, Gray C, Holmes S, Underwood JR, Beyreuther K, Masters CL, Evin G. Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products. Biochemistry. 37: 14958-65. PMID 9778373 DOI: 10.1021/bi981063l  0.96
1998 White AR, Zheng H, Galatis D, Maher F, Hesse L, Multhaup G, Beyreuther K, Masters CL, Cappai R. Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 6207-17. PMID 9698314  1
1998 Culvenor JG, Henry A, Hartmann T, Evin G, Galatis D, Friedhuber A, Jayasena UL, Underwood JR, Beyreuther K, Masters CL, Cappai R. Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 5: 79-89. PMID 9686302  1
1998 Sberna G, Sáez-Valero J, Li QX, Czech C, Beyreuther K, Masters CL, McLean CA, Small DH. Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the beta-amyloid protein precursor of Alzheimer's disease. Journal of Neurochemistry. 71: 723-31. PMID 9681463  0.96
1998 Postuma RB, Martins RN, Cappai R, Beyreuther K, Masters CL, Strickland DK, Mok SS, Small DH. Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture. Febs Letters. 428: 13-6. PMID 9645465 DOI: 10.1016/S0014-5793(98)00475-X  0.96
1998 Rondot S, Anthony KG, Dübel S, Ida N, Wiemann S, Beyreuther K, Frost LS, Little M, Breitling F. Epitopes fused to F-pilin are incorporated into functional recombinant pili. Journal of Molecular Biology. 279: 589-603. PMID 9641980 DOI: 10.1006/jmbi.1998.1773  0.96
1998 Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 95: 6460-4. PMID 9600988 DOI: 10.1073/pnas.95.11.6460  0.96
1998 Hass S, Fresser F, Köchl S, Beyreuther K, Utermann G, Baier G. Physical interaction of ApoE with amyloid precursor protein independent of the amyloid Abeta region in vitro. The Journal of Biological Chemistry. 273: 13892-7. PMID 9593736  0.36
1998 Multhaup G, Ruppert T, Schlicksupp A, Hesse L, Bill E, Pipkorn R, Masters CL, Beyreuther K. Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide. Biochemistry. 37: 7224-30. PMID 9585534 DOI: 10.1021/bi980022m  0.96
1998 Li QX, Whyte S, Tanner JE, Evin G, Beyreuther K, Masters CL. Secretion of Alzheimer's disease Abeta amyloid peptide by activated human platelets. Laboratory Investigation; a Journal of Technical Methods and Pathology. 78: 461-9. PMID 9564890  0.96
1998 Hock C, Golombowski S, Müller-Spahn F, Naser W, Beyreuther K, Mönning U, Schenk D, Vigo-Pelfrey C, Bush AM, Moir R, Tanzi RE, Growdon JH, Nitsch RM. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity. European Neurology. 39: 111-8. PMID 9520072 DOI: 10.1159/000007917  0.96
1998 Masters CL, Beyreuther K. Alzheimer's disease. Bmj (Clinical Research Ed.). 316: 446-8. PMID 9492674  1
1998 Moir RD, Lynch T, Bush AI, Whyte S, Henry A, Portbury S, Multhaup G, Small DH, Tanzi RE, Beyreuther K, Masters CL. Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain. The Journal of Biological Chemistry. 273: 5013-9. PMID 9478949 DOI: 10.1074/jbc.273.9.5013  0.96
1997 Bayer TA, Paliga K, Weggen S, Wiestler OD, Beyreuther K, Multhaup G. Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease. Acta Neuropathologica. 94: 519-24. PMID 9444352 DOI: 10.1007/s004010050745  0.96
1997 Paliga K, Peraus G, Kreger S, Dürrwang U, Hesse L, Multhaup G, Masters CL, Beyreuther K, Weidemann A. Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. European Journal of Biochemistry / Febs. 250: 354-63. PMID 9428684  1
1997 Schröder J, Pantel J, Ida N, Essig M, Hartmann T, Knopp MV, Schad LR, Sandbrink R, Sauer H, Masters CL, Beyreuther K. Cerebral changes and cerebrospinal fluid beta-amyloid in Alzheimer's disease: a study with quantitative magnetic resonance imaging. Molecular Psychiatry. 2: 505-7. PMID 9399697  0.96
1997 Lichtenthaler SF, Ida N, Multhaup G, Masters CL, Beyreuther K. Mutations in the transmembrane domain of APP altering gamma-secretase specificity. Biochemistry. 36: 15396-403. PMID 9398269 DOI: 10.1021/bi971071m  0.96
1997 Mills J, Laurent Charest D, Lam F, Beyreuther K, Ida N, Pelech SL, Reiner PB. Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 9415-22. PMID 9390997  0.96
1997 Coulson EJ, Barrett GL, Storey E, Bartlett PF, Beyreuther K, Masters CL. Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata. Brain Research. 770: 72-80. PMID 9372205 DOI: 10.1016/S0006-8993(97)00757-9  0.96
1997 Mok SS, Sberna G, Heffernan D, Cappai R, Galatis D, Clarris HJ, Sawyer WH, Beyreuther K, Masters CL, Small DH. Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease. Febs Letters. 415: 303-7. PMID 9357988 DOI: 10.1016/S0014-5793(97)01146-0  0.96
1997 Beyreuther K, Masters CL. Alzheimer's disease. The ins and outs of amyloid-beta. Nature. 389: 677-8. PMID 9338775 DOI: 10.1038/39479  1
1997 Multhaup G, Ruppert T, Schlicksupp A, Hesse L, Beher D, Masters CL, Beyreuther K. Reactive oxygen species and Alzheimer's disease. Biochemical Pharmacology. 54: 533-9. PMID 9337068 DOI: 10.1016/S0006-2952(97)00062-2  0.96
1997 Culvenor JG, Maher F, Evin G, Malchiodi-Albedi F, Cappai R, Underwood JR, Davis JB, Karran EH, Roberts GW, Beyreuther K, Masters CL. Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment. Journal of Neuroscience Research. 49: 719-31. PMID 9335259 DOI: 10.1002/(SICI)1097-4547(19970915)49:6<719::AID-JNR6>3.0.CO;2-A  1
1997 McLean CA, Beyreuther K, Masters CL. Commentary on the consensus recommendations for the post mortem diagnosis of Alzheimer's disease. Neurobiology of Aging. 18: S89-90. PMID 9330993 DOI: 10.1016/S0197-4580(97)00061-4  0.96
1997 Peraus GC, Masters CL, Beyreuther K. Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7714-24. PMID 9315893  1
1997 Hartmann T, Bieger SC, Brühl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K. Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nature Medicine. 3: 1016-20. PMID 9288729 DOI: 10.1038/nm0997-1016  0.96
1997 Sberna G, Sáez-Valero J, Beyreuther K, Masters CL, Small DH. The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells. Journal of Neurochemistry. 69: 1177-84. PMID 9282941  0.96
1997 Masters CL, Beyreuther K. Spongiform encephalopathies. Tracking turncoat prion proteins. Nature. 388: 228-9. PMID 9230425 DOI: 10.1038/40752  1
1997 Henry A, Masters CL, Beyreuther K, Cappai R. Expression of human amyloid precursor protein ectodomains in Pichia pastoris: analysis of culture conditions, purification, and characterization. Protein Expression and Purification. 10: 283-91. PMID 9226725 DOI: 10.1006/prep.1997.0748  1
1997 Czech C, Delaère P, Macq AF, Reibaud M, Dreisler S, Touchet N, Schombert B, Mazadier M, Mercken L, Theisen M, Pradier L, Octave JN, Beyreuther K, Tremp G. Proteolytical processing of mutated human amyloid precursor protein in transgenic mice. Brain Research. Molecular Brain Research. 47: 108-16. PMID 9221907  0.68
1997 Beyreuther K, Masters CL. Serpents on the road to dementia and death. Accumulating evidence from several studies points to the normal function of presenilin 1 and suggests how the mutant protein contributes to deposition of amyloid plaques in Alzheimer's disease. Nature Medicine. 3: 723-5. PMID 9212094  1
1997 Tienari PJ, Ida N, Ikonen E, Simons M, Weidemann A, Multhaup G, Masters CL, Dotti CG, Beyreuther K. Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 94: 4125-30. PMID 9108116 DOI: 10.1073/pnas.94.8.4125  0.96
1997 Weidemann A, Paliga K, Dürrwang U, Czech C, Evin G, Masters CL, Beyreuther K. Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein. Nature Medicine. 3: 328-32. PMID 9055862  1
1997 Clarris HJ, Cappai R, Heffernan D, Beyreuther K, Masters CL, Small DH. Identification of heparin-binding domains in the amyloid precursor protein of Alzheimer's disease by deletion mutagenesis and peptide mapping. Journal of Neurochemistry. 68: 1164-72. PMID 9048763  0.96
1997 Whyte S, Wilson N, Currie J, Maruff P, Malone V, Shafiq-Antonacci R, Tyler P, Derry KL, Underwood J, Li QX, Beyreuther K, Masters CL. Collection and normal levels of the amyloid precursor protein in plasma. Annals of Neurology. 41: 121-4. PMID 9005877 DOI: 10.1002/ana.410410122  1
1997 Sandbrink R, Mönning U, Masters CL, Beyreuther K. Expression of the APP gene family in brain cells, brain development and aging. Gerontology. 43: 119-31. PMID 8996834  1
1997 Mok SS, Evin G, Li QX, Smith AI, Beyreuther K, Masters CL, Small DH. A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments. Biochemistry. 36: 156-63. PMID 8993329 DOI: 10.1021/bi961848w  0.96
1997 Drache B, Diehl GE, Beyreuther K, Perlmutter LS, König G. Bcl-xl-specific antibody labels activated microglia associated with Alzheimer's disease and other pathological states. Journal of Neuroscience Research. 47: 98-108. PMID 8981243 DOI: 10.1002/(SICI)1097-4547(19970101)47:1<98::AID-JNR11>3.0.CO;2-6  0.96
1996 Tienari PJ, De Strooper B, Ikonen E, Ida N, Simons M, Masters CL, Dotti CG, Beyreuther K. Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease. Cold Spring Harbor Symposia On Quantitative Biology. 61: 575-85. PMID 9246484  0.96
1996 Sandbrink R, Beyreuther K. Unraveling the molecular pathway of Alzheimer's disease: research about presenilins gathers momentum. Molecular Psychiatry. 1: 438-44. PMID 9154244  0.72
1996 Sandbrink R, Hartmann T, Masters CL, Beyreuther K. Genes contributing to Alzheimer's disease. Molecular Psychiatry. 1: 27-40. PMID 9118312  1
1996 Förstl H, Sattel H, Sarochan M, Besthom C, Czech C, Daniel S, Geiger-Kabisch C, Hentschel F, Zerfass R, Beyreuther K. [Alzheimer dementia and normal aging. Clinical, neuroradiologic, neurophysiologic and molecular biology follow-up data]. Der Nervenarzt. 67: 730-8. PMID 8992370  0.68
1996 Williamson TG, Mok SS, Henry A, Cappai R, Lander AD, Nurcombe V, Beyreuther K, Masters CL, Small DH. Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth. The Journal of Biological Chemistry. 271: 31215-21. PMID 8940123 DOI: 10.1074/jbc.271.49.31215  0.96
1996 Beyreuther K, Multhaup G, Masters CL. Alzheimer's disease: genesis of amyloid. Ciba Foundation Symposium. 199: 119-27; discussion 1. PMID 8915607  1
1996 Storey E, Beyreuther K, Masters CL. Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components. Brain Research. 735: 217-31. PMID 8911660  1
1996 Storey E, Spurck T, Pickett-Heaps J, Beyreuther K, Masters CL. The amyloid precursor protein of Alzheimer's disease is found on the surface of static but not activity motile portions of neurites. Brain Research. 735: 59-66. PMID 8905170  1
1996 Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C, Hartmann T, Ida N, Multhaup G, Masters CL, Van Leuven F, Beyreuther K, Dotti CG. The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein. The Embo Journal. 15: 5218-29. PMID 8895567  0.96
1996 Sarochan M, Förstl H, Sattel H, Zerfass R, Czech C, Beyreuther K. Apolipoprotein E genotype does not promote the clinical progression of manifest Alzheimer's disease. Dementia (Basel, Switzerland). 7: 120. PMID 8866687  0.68
1996 Thilmann P, Ernst C, Czech C, Kaumeier S, Beyreuther K, Förstl H. Low apolipoprotein E4 allelic frequency in Alzheimer's disease and functional psychiatric disorders. Dementia (Basel, Switzerland). 7: 118-9. PMID 8866686  0.68
1996 Beyreuther K, Masters CL. Alzheimer's disease. Tangle disentanglement. Nature. 383: 476-7. PMID 8849716 DOI: 10.1038/383476a0  1
1996 Ida N, Masters CL, Beyreuther K. Rapid cellular uptake of Alzheimer amyloid betaA4 peptide by cultured human neuroblastoma cells. Febs Letters. 394: 174-8. PMID 8843158 DOI: 10.1016/0014-5793(96)00948-9  0.96
1996 Bayer TA, Fossgreen A, Czech C, Beyreuther K, Wiestler OD. Plaque formation in brain transplants exposed to human beta-amyloid precursor protein 695. Acta Neuropathologica. 92: 130-7. PMID 8841658  0.68
1996 Ida N, Hartmann T, Pantel J, Schröder J, Zerfass R, Förstl H, Sandbrink R, Masters CL, Beyreuther K. Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. The Journal of Biological Chemistry. 271: 22908-14. PMID 8798471 DOI: 10.1074/jbc.271.37.22908  0.96
1996 Sandbrink R, Zhang D, Schaeffer S, Masters CL, Bauer J, Förstl H, Beyreuther K. Missense mutations of the PS-1/S182 gene in German early-onset Alzheimer's disease patients. Annals of Neurology. 40: 265-6. PMID 8773614 DOI: 10.1002/ana.410400225  1
1996 Hartmann T, Bergsdorf C, Sandbrink R, Tienari PJ, Multhaup G, Ida N, Bieger S, Dyrks T, Weidemann A, Masters CL, Beyreuther K. Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing. The Journal of Biological Chemistry. 271: 13208-14. PMID 8662794 DOI: 10.1074/jbc.271.22.13208  0.96
1996 Beyreuther K, Multhaup G, Mönning U, Sandbrink R, Beher D, Hesse L, Small DH, Masters CL. Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines. Annals of the New York Academy of Sciences. 777: 74-6. PMID 8624129  0.96
1996 Small DH, Williamson T, Reed G, Clarris H, Beyreuther K, Masters CL, Nurcombe V. The role of heparan sulfate proteoglycans in the pathogenesis of Alzheimer's disease. Annals of the New York Academy of Sciences. 777: 316-21. PMID 8624106  0.96
1996 Sandbrink R, Masters CL, Beyreuther K. APP gene family. Alternative splicing generates functionally related isoforms. Annals of the New York Academy of Sciences. 777: 281-7. PMID 8624099  1
1996 Multhaup G, Schlicksupp A, Hesse L, Beher D, Ruppert T, Masters CL, Beyreuther K. The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) Science (New York, N.Y.). 271: 1406-9. PMID 8596911  0.96
1996 Simons M, de Strooper B, Multhaup G, Tienari PJ, Dotti CG, Beyreuther K. Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 899-908. PMID 8558258  0.96
1995 Evin G, Beyreuther K, Masters CL. A synthetic substrate assay for the gamma-secretase of the beta-A4 amyloid of Alzheimer's disease. Journal of Peptide Science : An Official Publication of the European Peptide Society. 1: 132-9. PMID 9222990 DOI: 10.1002/psc.310010205  1
1995 Urmoneit B, Reinsch C, Turner J, Czech C, Beyreuther K, Dyrks T. Inhibition of beta A4 production by specific modulation of beta-secretase activity. Journal of Molecular Neuroscience : Mn. 6: 23-32. PMID 8562317 DOI: 10.1007/BF02736756  0.68
1995 LePage RN, Fosang AJ, Fuller SJ, Murphy G, Evin G, Beyreuther K, Masters CL, Small DH. Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease. Febs Letters. 377: 267-70. PMID 8543065 DOI: 10.1016/0014-5793(95)01358-X  0.96
1995 Fuller SJ, Storey E, Li QX, Smith AI, Beyreuther K, Masters CL. Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein. Biochemistry. 34: 8091-8. PMID 7794922  0.96
1995 Li QX, Evin G, Small DH, Multhaup G, Beyreuther K, Masters CL. Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets. The Journal of Biological Chemistry. 270: 14140-7. PMID 7775475 DOI: 10.1074/jbc.270.23.14140  0.96
1995 Masters CL, Beyreuther K. Molecular neuropathology of Alzheimer's disease. Arzneimittel-Forschung. 45: 410-2. PMID 7763335  1
1995 Förstl H, Hentschel F, Sattel H, Geiger-Kabisch C, Besthorn C, Czech C, Mönning U, Beyreuther K. Age-associated memory impairment and early Alzheimer's disease. Only time will tell the difference. Arzneimittel-Forschung. 45: 394-7. PMID 7763332  0.72
1995 Beyreuther K, Masters CL. Neurodegeneration and dementia. Alzheimer's disease as a model. Arzneimittel-Forschung. 45: 347-50. PMID 7763324  1
1995 Mönning U, Sandbrink R, Weidemann A, Banati RB, Masters CL, Beyreuther K. Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells. The Journal of Biological Chemistry. 270: 7104-10. PMID 7706247 DOI: 10.1074/jbc.270.13.7104  0.96
1995 Simons M, Ikonen E, Tienari PJ, Cid-Arregui A, Mönning U, Beyreuther K, Dotti CG. Intracellular routing of human amyloid protein precursor: axonal delivery followed by transport to the dendrites. Journal of Neuroscience Research. 41: 121-8. PMID 7674373 DOI: 10.1002/jnr.490410114  0.96
1995 Zhan SS, Sandbrink R, Beyreuther K, Schmitt HP. APP with Kunitz type protease inhibitor domain (KPI) correlates with neuritic plaque density but not with cortical synaptophysin immunoreactivity in Alzheimer's disease and non-demented aged subjects: a multifactorial analysis. Clinical Neuropathology. 14: 142-9. PMID 7671455  0.72
1995 Eckert A, Förstl H, Hartmann H, Czech C, Mönning U, Beyreuther K, Müller WE. The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease. Neuroreport. 6: 1199-202. PMID 7662907  0.72
1995 Simons M, Tienari PJ, Dotti CG, Beyreuther K. Two-dimensional gel mapping of the processing of the human amyloid precursor protein in rat hippocampal neurons. Febs Letters. 368: 363-6. PMID 7628638 DOI: 10.1016/0014-5793(95)00654-R  0.96
1995 Beer J, Masters CL, Beyreuther K. Cells from peripheral tissues that exhibit high APP expression are characterized by their high membrane fusion activity. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 4: 51-9. PMID 7600184  1
1995 Williamson TG, Nurcombe V, Beyreuther K, Masters CL, Small DH. Affinity purification of proteoglycans that bind to the amyloid protein precursor of Alzheimer's disease. Journal of Neurochemistry. 65: 2201-8. PMID 7595508  0.96
1995 Sticht H, Bayer P, Willbold D, Dames S, Hilbich C, Beyreuther K, Frank RW, Rösch P. Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease. European Journal of Biochemistry / Febs. 233: 293-8. PMID 7588758  0.96
1995 De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG. Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. The Embo Journal. 14: 4932-8. PMID 7588622  0.96
1995 Evin G, Cappai R, Li QX, Culvenor JG, Small DH, Beyreuther K, Masters CL. Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta A4 amyloid: possible involvement of cathepsin D. Biochemistry. 34: 14185-92. PMID 7578016  1
1995 Meyer-Franke A, Tropak MB, Roder JC, Fischer P, Beyreuther K, Probstmeier R, Schachner M. Functional topography of myelin-associated glycoprotein. II. Mapping of domains on molecular fragments. Journal of Neuroscience Research. 41: 311-23. PMID 7563224 DOI: 10.1002/jnr.490410304  0.96
1995 Culvenor JG, Friedhuber A, Fuller SJ, Beyreuther K, Masters CL. Expression of the amyloid precursor protein of Alzheimer's disease on the surface of transfected HeLa cells. Experimental Cell Research. 220: 474-81. PMID 7556457 DOI: 10.1006/excr.1995.1339  1
1995 Clarris HJ, Key B, Beyreuther K, Masters CL, Small DH. Expression of the amyloid protein precursor of Alzheimer's disease in the developing rat olfactory system. Brain Research. Developmental Brain Research. 88: 87-95. PMID 7493410 DOI: 10.1016/0165-3806(95)00083-P  0.96
1994 Sandbrink R, Masters CL, Beyreuther K. APP gene family: unique age-associated changes in splicing of Alzheimer's betaA4-amyloid protein precursor. Neurobiology of Disease. 1: 13-24. PMID 9216982 DOI: 10.1006/nbdi.1994.0003  1
1994 Sandbrink R, Masters CL, Beyreuther K. Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. The Journal of Biological Chemistry. 269: 1510-7. PMID 8288617  1
1994 Sandbrink R, Masters CL, Beyreuther K. Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins. The Journal of Biological Chemistry. 269: 14227-34. PMID 8188705  1
1994 Czech C, Förstl H, Hentschel F, Mönning U, Besthorn C, Geiger-Kabisch C, Sattel H, Masters C, Beyreuther K. Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change. European Archives of Psychiatry and Clinical Neuroscience. 243: 291-2. PMID 8172944  0.72
1994 Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K, Masters CL. A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 2117-27. PMID 8158260  0.96
1994 Mönning U, Sandbrink R, Banati RB, Masters CL, Beyreuther K. Transforming growth factor beta mediates increase of mature transmembrane amyloid precursor protein in microglial cells. Febs Letters. 342: 267-72. PMID 8150082 DOI: 10.1016/0014-5793(94)80514-8  0.96
1994 Masters CL, Beyreuther K. Alzheimer's disease: a clearer definition of the genetic components. The Medical Journal of Australia. 160: 243-4. PMID 8107621  1
1994 Sandbrink R, Masters CL, Beyreuther K. Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues. Biochimica Et Biophysica Acta. 1219: 167-70. PMID 8086458  1
1994 Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel JP, Gusella JF, Beyreuther K, Masters CL, Tanzi RE. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (New York, N.Y.). 265: 1464-7. PMID 8073293  1
1994 Dyrks T, Mönning U, Beyreuther K, Turner J. Amyloid precursor protein secretion and beta A4 amyloid generation are not mutually exclusive. Febs Letters. 349: 210-4. PMID 8050568  0.72
1994 Beyreuther K, Masters CL. Neurobiology. Catching the culprit prion. Nature. 370: 419-20. PMID 8047160 DOI: 10.1038/370419a0  1
1994 Li QX, Berndt MC, Bush AI, Rumble B, Mackenzie I, Friedhuber A, Beyreuther K, Masters CL. Membrane-associated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelet and brain: surface expression on the activated human platelet. Blood. 84: 133-42. PMID 8018913  1
1994 Clarris HJ, Nurcombe V, Small DH, Beyreuther K, Masters CL. Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants. Journal of Neuroscience Research. 38: 248-58. PMID 7932862 DOI: 10.1002/jnr.490380303  0.96
1994 Czech C, Masters C, Beyreuther K. Alzheimer's disease and transgenic mice. Journal of Neural Transmission. Supplementum. 44: 219-30. PMID 7897394  0.68
1994 Förstl H, Czech C, Sattel H, Geiger-Kabisch C, Besthorn C, Kreger S, Mönning U, Hartmann T, Masters C, Beyreuther K. [Apolipoprotein E and Alzheimer dementia. Personal results and brief literature review]. Der Nervenarzt. 65: 780-6. PMID 7816155  0.72
1994 Banati RB, Gehrmann J, Mönning U, Czech C, Beyreuther K, Kreutzberg GW. Amyloid precursor protein (APP) as a microglial acute phase protein. Neuropathology and Applied Neurobiology. 20: 194-5. PMID 7521020  0.96
1993 Dyrks T, Dyrks E, Masters CL, Beyreuther K. Amyloidogenicity of rodent and human beta A4 sequences. Febs Letters. 324: 231-6. PMID 8508926  1
1993 Multhaup G, Masters CL, Beyreuther K. A molecular approach to Alzheimer's disease. Biological Chemistry Hoppe-Seyler. 374: 1-8. PMID 8439394  1
1993 Bush AI, Multhaup G, Moir RD, Williamson TG, Small DH, Rumble B, Pollwein P, Beyreuther K, Masters CL. A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. The Journal of Biological Chemistry. 268: 16109-12. PMID 8344894  0.96
1993 Seelig A, Multhaup G, Pesold-Hurt B, Beyreuther K, Kloetzel PM. Drosophila proteasome Dm25 subunit substitutes the mouse MC3 subunit in hybrid proteasomes. The N-terminal domain is essential for subunit incorporation. The Journal of Biological Chemistry. 268: 25561-7. PMID 8244993  0.96
1993 Dyrks T, Dyrks E, Mönning U, Urmoneit B, Turner J, Beyreuther K. Generation of beta A4 from the amyloid protein precursor and fragments thereof. Febs Letters. 335: 89-93. PMID 8243673  0.72
1993 Beyreuther K, Pollwein P, Multhaup G, Mönning U, König G, Dyrks T, Schubert W, Masters CL. Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome. Annals of the New York Academy of Sciences. 695: 91-102. PMID 8239320  1
1993 Sandbrink R, Banati R, Masters CL, Beyreuther K, König G. Expression of L-APP mRNA in brain cells. Annals of the New York Academy of Sciences. 695: 183-9. PMID 8239280 DOI: 10.1111/j.1749-6632.1993.tb23049.x  0.96
1993 Bush AI, Beyreuther K, Masters CL. The beta A4 amyloid protein precursor in human circulation. Annals of the New York Academy of Sciences. 695: 175-82. PMID 8239279  1
1993 Small DH, Nurcombe V, Clarris H, Beyreuther K, Masters CL. The role of extracellular matrix in the processing of the amyloid protein precursor of Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 169-74. PMID 8239278 DOI: 10.1111/j.1749-6632.1993.tb23047.x  0.96
1993 Guiroy DC, Mellini M, Miyazaki M, Hilbich C, Safar J, Garruto RM, Yanagihara R, Beyreuther K, Gajdusek DC. Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4- to 4.5-kilodalton protein which is immunoreactive to anti-amyloid beta/A4-protein antibodies. Acta Neuropathologica. 86: 265-74. PMID 8213085 DOI: 10.1007/BF00304141  0.96
1993 Dichgans M, Mönning U, König G, Sandbrink R, Masters CL, Beyreuther K. APP expression in primary neuronal cell cultures from P6 mice during in vitro differentiation. Dementia (Basel, Switzerland). 4: 301-7. PMID 8136892  1
1993 Schubert W, Masters CL, Beyreuther K. APP+ T lymphocytes selectively sorted to endomysial tubes in polymyositis displace NCAM-expressing muscle fibers. European Journal of Cell Biology. 62: 333-42. PMID 7925489  1
1993 Czech C, Mönning V, Tienari PJ, Hartmann T, Masters C, Beyreuther K, Förstl H. Apolipoprotein E-epsilon 4 allele and Alzheimer's disease. Lancet. 342: 1309. PMID 7901624  0.68
1993 Gearing M, Wilson RW, Unger ER, Shelton ER, Chan HW, Masters CL, Beyreuther K, Mirra SS. Amyloid precursor protein (APP) in the striatum in Alzheimer's disease: an immunohistochemical study. Journal of Neuropathology and Experimental Neurology. 52: 22-30. PMID 7678853  0.96
1993 Banati RB, Gehrmann J, Czech C, Mönning U, Jones LL, König G, Beyreuther K, Kreutzberg GW. Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia. Glia. 9: 199-210. PMID 7507467 DOI: 10.1002/glia.440090305  0.96
1993 Hilbich C, Mönning U, Grund C, Masters CL, Beyreuther K. Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11. The Journal of Biological Chemistry. 268: 26571-7. PMID 7504673  1
1992 Pollwein P, Masters CL, Beyreuther K. The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter. Nucleic Acids Research. 20: 63-8. PMID 1738605  1
1992 Milward EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, Beyreuther K, Masters CL. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron. 9: 129-37. PMID 1632967 DOI: 10.1016/0896-6273(92)90228-6  0.96
1992 König G, Mönning U, Czech C, Prior R, Banati R, Schreiter-Gasser U, Bauer J, Masters CL, Beyreuther K. Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells. The Journal of Biological Chemistry. 267: 10804-9. PMID 1587857  1
1992 Dyrks T, Dyrks E, Hartmann T, Masters C, Beyreuther K. Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation. The Journal of Biological Chemistry. 267: 18210-7. PMID 1517249  0.56
1992 Dyrks T, Dyrks E, Masters C, Beyreuther K. Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate. Febs Letters. 309: 20-4. PMID 1511741  0.56
1992 Hilbich C, Kisters-Woike B, Reed J, Masters CL, Beyreuther K. Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. Journal of Molecular Biology. 228: 460-73. PMID 1453457  1
1992 Mönning U, König G, Banati RB, Mechler H, Czech C, Gehrmann J, Schreiter-Gasser U, Masters CL, Beyreuther K. Alzheimer beta A4-amyloid protein precursor in immunocompetent cells. The Journal of Biological Chemistry. 267: 23950-6. PMID 1429732  0.96
1992 Beyreuther K, Dyrks T, Hilbich C, Mönning U, König G, Multhaup G, Pollwein P, Masters CL. Amyloid precursor protein (APP) and beta A4 amyloid in Alzheimer's disease and Down syndrome. Progress in Clinical and Biological Research. 379: 159-82. PMID 1409743  1
1992 Moir RD, Martins RN, Bush AI, Small DH, Milward EA, Rumble BA, Multhaup G, Beyreuther K, Masters CL. Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization. Journal of Neurochemistry. 59: 1490-8. PMID 1402900  0.96
1992 Prior P, Schmitt B, Grenningloh G, Pribilla I, Multhaup G, Beyreuther K, Maulet Y, Werner P, Langosch D, Kirsch J. Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Neuron. 8: 1161-70. PMID 1319186  0.64
1992 Bush AI, Beyreuther K, Masters CL. Beta A4 amyloid protein and its precursor in Alzheimer's disease. Pharmacology & Therapeutics. 56: 97-117. PMID 1297146  1
1992 Small DH, Nurcombe V, Moir R, Michaelson S, Monard D, Beyreuther K, Masters CL. Association and release of the amyloid protein precursor of Alzheimer's disease from chick brain extracellular matrix. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4143-50. PMID 1279136  0.96
1991 Hilbich C, Kisters-Woike B, Reed J, Masters CL, Beyreuther K. Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease. Journal of Molecular Biology. 218: 149-63. PMID 2002499  1
1991 Martin JJ, Gheuens J, Bruyland M, Cras P, Vandenberghe A, Masters CL, Beyreuther K, Dom R, Ceuterick C, Lübke U. Early-onset Alzheimer's disease in 2 large Belgian families. Neurology. 41: 62-8. PMID 1985297  0.96
1991 Hilbich C, Kisters-Woike B, Reed J, Masters CL, Beyreuther K. Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4. European Journal of Biochemistry / Febs. 201: 61-9. PMID 1915378  1
1991 Martin LJ, Sisodia SS, Koo EH, Cork LC, Dellovade TL, Weidemann A, Beyreuther K, Masters C, Price DL. Amyloid precursor protein in aged nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America. 88: 1461-5. PMID 1899927  0.68
1991 Richards SJ, Waters JJ, Beyreuther K, Masters CL, Wischik CM, Sparkman DR, White CL, Abraham CR, Dunnett SB. Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology. The Embo Journal. 10: 297-303. PMID 1899372  0.96
1991 König G, Salbaum JM, Wiestler O, Lang W, Schmitt HP, Masters CL, Beyreuther K. Alternative splicing of the beta A4 amyloid gene of Alzheimer's disease in cortex of control and Alzheimer's disease patients. Brain Research. Molecular Brain Research. 9: 259-62. PMID 1851528  1
1991 Martins RN, Robinson PJ, Chleboun JO, Beyreuther K, Masters CL. The molecular pathology of amyloid deposition in Alzheimer's disease. Molecular Neurobiology. 5: 389-98. PMID 1823142  1
1991 Schubert W, Prior R, Weidemann A, Dircksen H, Multhaup G, Masters CL, Beyreuther K. Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites. Brain Research. 563: 184-94. PMID 1786532  1
1991 Beyreuther K, Bush AI, Dyrks T, Hilbich C, König G, Mönning U, Multhaup G, Prior R, Rumble B, Schubert W. Mechanisms of amyloid deposition in Alzheimer's disease. Annals of the New York Academy of Sciences. 640: 129-39. PMID 1776729  0.96
1991 Small DH, Moir RD, Fuller SJ, Michaelson S, Bush AI, Li QX, Milward E, Hilbich C, Weidemann A, Beyreuther K. A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease. Biochemistry. 30: 10795-9. PMID 1718425  0.96
1991 Ganter U, Strauss S, Jonas U, Weidemann A, Beyreuther K, Volk B, Berger M, Bauer J. Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells. Potential significance for the processing of Alzheimer beta-amyloid precursor protein. Febs Letters. 282: 127-31. PMID 1709116  0.68
1991 Gajdusek DC, Beyreuther K, Brown P, Cork LC, Cunningham DD, Frangione B, Gibbs CJ, Goldfarb LG, Goldgaber D, Hsiao KK. Regulation and genetic control of brain amyloid. FESN Study Group. Brain Research. Brain Research Reviews. 16: 83-114. PMID 1677826 DOI: 10.1016/0165-0173(91)90021-Y  0.96
1991 Kitamoto T, Muramoto T, Hilbich C, Beyreuther K, Tateishi J. N-terminal sequence of prion protein is also integrated into kuru plaques in patients with Gerstmann-Sträussler syndrome. Brain Research. 545: 319-21. PMID 1677605  0.64
1991 Prior R, Mönning U, Schreiter-Gasser U, Weidemann A, Blennow K, Gottfries CG, Masters CL, Beyreuther K. Quantitative changes in the amyloid beta A4 precursor protein in Alzheimer cerebrospinal fluid. Neuroscience Letters. 124: 69-73. PMID 1677459  1
1991 Beyreuther K, Masters CL. Amyloid precursor protein (APP) and beta A4 amyloid in the etiology of Alzheimer's disease: precursor-product relationships in the derangement of neuronal function. Brain Pathology (Zurich, Switzerland). 1: 241-51. PMID 1669714  1
1991 Masters CL, Beyreuther K. Alzheimer's disease: molecular basis of structural lesions. Brain Pathology (Zurich, Switzerland). 1: 226-7. PMID 1669713  1
1990 Mönning U, König G, Prior R, Mechler H, Schreiter-Gasser U, Masters CL, Beyreuther K. Synthesis and secretion of Alzheimer amyloid beta A4 precursor protein by stimulated human peripheral blood leucocytes. Febs Letters. 277: 261-6. PMID 2125277  1
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