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Thomas S. Hnasko, PhD - Publications

Affiliations: 
2000-2006 Neurobiology & Behavior Graduate Program University of Washington, Seattle, Seattle, WA 
 2006-2011 Physiology University of California, San Francisco, San Francisco, CA 
 2012- Neurosciences University of California, San Diego, La Jolla, CA 
Area:
neurotransmitters, dopamine, glutamate, vesicular transporters, synaptic physiology, addiction
Website:
hnaskolab.ucsd.edu
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59/64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Warlow SM, Singhal SM, Hollon NG, Faget L, Dowlat DS, Zell V, Hunker AC, Zweifel LS, Hnasko TS. Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release. Neuron. PMID 38086374 DOI: 10.1016/j.neuron.2023.11.002  0.853
2023 Buck SA, Rubin SA, Kunkhyen T, Treiber CD, Xue X, Fenno LE, Mabry SJ, Sundar VR, Yang Z, Shah D, Ketchesin KD, Becker-Krail DD, Vasylieva I, Smith MC, Weisel FJ, ... ... Hnasko TS, et al. Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration. Biorxiv : the Preprint Server For Biology. PMID 37873436 DOI: 10.1101/2023.10.02.560584  0.486
2023 Faget L, Oriol L, Lee WC, Sargent C, Ramanathan D, Hnasko TS. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. Biorxiv : the Preprint Server For Biology. PMID 37502884 DOI: 10.1101/2023.07.12.548750  0.844
2023 Singhal SM, Zell V, Faget L, Slosky LM, Barak LS, Caron MG, Pinkerton AB, Hnasko TS. Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens. Neuropharmacology. 109544. PMID 37055008 DOI: 10.1016/j.neuropharm.2023.109544  0.837
2022 Barnes SA, Dillon DG, Young JW, Thomas ML, Faget L, Yoo JH, Der-Avakian A, Hnasko TS, Geyer MA, Ramanathan DS. Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making. Cerebral Cortex (New York, N.Y. : 1991). PMID 36472411 DOI: 10.1093/cercor/bhac459  0.801
2021 Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain : a Journal of Neurology. PMID 35258081 DOI: 10.1093/brain/awab373  0.812
2021 Souter EA, Chen YC, Zell V, Lallai V, Steinkellner T, Conrad WS, Wisden W, Harris KD, Fowler CD, Hnasko TS. Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration. Eneuro. PMID 34876472 DOI: 10.1523/ENEURO.0481-21.2021  0.777
2021 Maimon R, Chillon-Marinas C, Snethlage CE, Singhal SM, McAlonis-Downes M, Ling K, Rigo F, Bennett CF, Da Cruz S, Hnasko TS, Muotri AR, Cleveland DW. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nature Neuroscience. PMID 34083786 DOI: 10.1038/s41593-021-00864-y  0.424
2021 Buck SA, Steinkellner T, Aslanoglou D, Villeneuve M, Bhatte SH, Childers VC, Rubin SA, De Miranda BR, O'Leary EI, Neureiter EG, Fogle KJ, Palladino MJ, Logan RW, Glausier JR, Fish KN, ... ... Hnasko TS, et al. Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration. Aging Cell. e13365. PMID 33909313 DOI: 10.1111/acel.13365  0.797
2021 Farrell MR, Esteban JSD, Faget L, Floresco SB, Hnasko TS, Mahler SV. Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 41: 4500-4513. PMID 33837052 DOI: 10.1523/JNEUROSCI.2039-20.2021  0.818
2021 Renteria R, Cazares C, Baltz ET, Schreiner DC, Yalcinbas EA, Steinkellner T, Hnasko TS, Gremel CM. Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure. Elife. 10. PMID 33729155 DOI: 10.7554/eLife.67065  0.719
2021 Steinkellner T, Madany M, Haberl MG, Zell V, Li C, Hu J, Mackey M, Ramachandra R, Adams S, Ellisman MH, Hnasko TS, Boassa D. Genetic Probe for Visualizing Glutamatergic Synapses and Vesicles by 3D Electron Microscopy. Acs Chemical Neuroscience. PMID 33522227 DOI: 10.1021/acschemneuro.0c00643  0.797
2020 Zell V, Steinkellner T, Hollon NG, Warlow SM, Souter E, Faget L, Hunker AC, Jin X, Zweifel LS, Hnasko TS. VTA Glutamate Neuron Activity Drives Positive Reinforcement Absent Dopamine Co-release. Neuron. PMID 32610039 DOI: 10.1016/J.Neuron.2020.06.011  0.797
2020 Khom S, Steinkellner T, Hnasko TS, Roberto M. Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala. Science Advances. 6: eaaz1050. PMID 32206720 DOI: 10.1126/Sciadv.Aaz1050  0.686
2020 Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, ... ... Hnasko TS, et al. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metabolism. PMID 32142669 DOI: 10.1016/J.Cmet.2020.02.010  0.506
2019 Farrell MR, Ruiz CM, Castillo E, Faget L, Khanbijian C, Liu S, Schoch H, Rojas G, Huerta MY, Hnasko TS, Mahler SV. Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31476762 DOI: 10.1038/S41386-019-0507-4  0.752
2019 Steinkellner T, Yoo JH, Hnasko TS. Differential expression of VGLUT2 in mouse mesopontine cholinergic neurons. Eneuro. PMID 31366590 DOI: 10.1523/ENEURO.0161-19.2019  0.85
2019 Romoli B, Lozada AF, Sandoval IM, Manfredsson FP, Hnasko TS, Berg DK, Dulcis D. Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption. Biological Psychiatry. PMID 31202491 DOI: 10.1016/J.Biopsych.2019.04.019  0.448
2019 Bimpisidis Z, König N, Stagkourakis S, Zell V, Vlcek B, Dumas S, Giros B, Broberger C, Hnasko TS, Wallén-Mackenzie Å. The NeuroD6 subtype of VTA neurons contributes to psychostimulant sensitization and behavioral reinforcement. Eneuro. PMID 31097625 DOI: 10.1523/ENEURO.0066-19.2019  0.86
2018 Faget L, Zell V, Souter E, McPherson A, Ressler R, Gutierrez-Reed N, Yoo JH, Dulcis D, Hnasko TS. Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum. Nature Communications. 9: 849. PMID 29487284 DOI: 10.1038/S41467-018-03125-Y  0.799
2018 Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA, Lu W. Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular Psychiatry. PMID 29459796 DOI: 10.1038/mp.2018.3  0.469
2018 Steinkellner T, Zell V, Farino ZJ, Sonders MS, Villeneuve M, Freyberg RJ, Przedborski S, Lu W, Freyberg Z, Hnasko TS. Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. The Journal of Clinical Investigation. PMID 29337309 DOI: 10.1172/Jci95795  0.855
2017 Fife KH, Gutierrez-Reed NA, Zell V, Bailly J, Lewis CM, Aron AR, Hnasko TS. Causal role for the subthalamic nucleus in interrupting behavior. Elife. 6. PMID 28742497 DOI: 10.7554/Elife.27689  0.818
2017 Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, ... ... Hnasko TS, et al. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metabolism. 25: 975. PMID 28380385 DOI: 10.1016/J.Cmet.2017.03.001  0.835
2017 Wang DV, Viereckel T, Zell V, Konradsson-Geuken Å, Broker CJ, Talishinsky A, Yoo JH, Galinato MH, Arvidsson E, Kesner AJ, Hnasko TS, Wallén-Mackenzie Å, Ikemoto S. Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation. Cell Reports. 18: 2584-2591. PMID 28297663 DOI: 10.1016/J.Celrep.2017.02.062  0.873
2017 Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA, Lu W. Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular Psychiatry. PMID 28194005 DOI: 10.1038/Mp.2017.7  0.612
2017 Yoo JH, Zell V, Wu J, Punta C, Ramajayam N, Shen X, Faget L, Lilascharoen V, Lim BK, Hnasko TS. Activation of Pedunculopontine Glutamate Neurons Is Reinforcing. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 38-46. PMID 28053028 DOI: 10.1523/Jneurosci.3082-16.2016  0.864
2017 Fife KH, Gutierrez-Reed NA, Zell V, Bailly J, Lewis CM, Aron AR, Hnasko TS. Author response: Causal role for the subthalamic nucleus in interrupting behavior Elife. DOI: 10.7554/Elife.27689.016  0.786
2016 Berland C, Cansell C, Hnasko TS, Magnan C, Luquet S. Dietary triglycerides as signaling molecules that influence reward and motivation. Current Opinion in Behavioral Sciences. 9: 126-135. PMID 28191490 DOI: 10.1016/J.Cobeha.2016.03.005  0.396
2016 Yoo JH, Zell V, Gutierrez-Reed N, Wu J, Ressler R, Shenasa MA, Johnson AB, Fife KH, Faget L, Hnasko TS. Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement. Nature Communications. 7: 13697. PMID 27976722 DOI: 10.1038/Ncomms13697  0.851
2016 Soden ME, Miller SM, Burgeno LM, Phillips PE, Hnasko TS, Zweifel LS. Genetic Isolation of Hypothalamic Neurons that Regulate Context-Specific Male Social Behavior. Cell Reports. PMID 27346361 DOI: 10.1016/J.Celrep.2016.05.067  0.71
2016 Faget L, Osakada F, Duan J, Ressler R, Johnson AB, Proudfoot JA, Yoo JH, Callaway EM, Hnasko TS. Afferent Inputs to Neurotransmitter-Defined Cell Types in the Ventral Tegmental Area. Cell Reports. PMID 27292633 DOI: 10.1016/J.Celrep.2016.05.057  0.86
2015 Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA. Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output. Molecular Metabolism. 4: 857-866. PMID 26629409 DOI: 10.1016/J.Molmet.2015.09.001  0.527
2015 Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, ... ... Hnasko TS, et al. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metabolism. PMID 26278050 DOI: 10.1016/J.Cmet.2015.07.011  0.835
2015 Faget L, Hnasko TS. Tyramide Signal Amplification for Immunofluorescent Enhancement. Methods in Molecular Biology (Clifton, N.J.). 1318: 161-72. PMID 26160574 DOI: 10.1007/978-1-4939-2742-5_16  0.715
2014 Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 14304-17. PMID 25339743 DOI: 10.1523/Jneurosci.0930-14.2014  0.561
2014 Trudeau LE, Hnasko TS, Wallén-Mackenzie A, Morales M, Rayport S, Sulzer D. The multilingual nature of dopamine neurons. Progress in Brain Research. 211: 141-64. PMID 24968779 DOI: 10.1016/B978-0-444-63425-2.00006-4  0.655
2014 Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, ... Hnasko TS, et al. Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Molecular Psychiatry. 19: 1095-105. PMID 24732670 DOI: 10.1038/Mp.2014.31  0.37
2013 Delwig A, Majumdar S, Ahern K, LaVail MM, Edwards R, Hnasko TS, Copenhagen DR. Glutamatergic neurotransmission from melanopsin retinal ganglion cells is required for neonatal photoaversion but not adult pupillary light reflex. Plos One. 8: e83974. PMID 24391855 DOI: 10.1371/Journal.Pone.0083974  0.462
2013 Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron. 79: 970-86. PMID 24012009 DOI: 10.1016/J.Neuron.2013.06.043  0.566
2012 Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH. Ventral tegmental area glutamate neurons: electrophysiological properties and projections. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15076-85. PMID 23100428 DOI: 10.1523/Jneurosci.3128-12.2012  0.747
2012 Hnasko TS, Edwards RH. Neurotransmitter corelease: mechanism and physiological role. Annual Review of Physiology. 74: 225-43. PMID 22054239 DOI: 10.1146/Annurev-Physiol-020911-153315  0.599
2011 Talpalar AE, Endo T, Löw P, Borgius L, Hägglund M, Dougherty KJ, Ryge J, Hnasko TS, Kiehn O. Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord. Neuron. 71: 1071-84. PMID 21943604 DOI: 10.1016/J.Neuron.2011.07.011  0.361
2011 Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH. Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. Nature Neuroscience. 14: 1285-92. PMID 21874016 DOI: 10.1038/Nn.2898  0.465
2011 Koch SM, Dela Cruz CG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM. Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron. 71: 235-42. PMID 21791283 DOI: 10.1016/J.Neuron.2011.05.045  0.462
2010 Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proceedings of the National Academy of Sciences of the United States of America. 107: 22296-301. PMID 21135246 DOI: 10.1073/Pnas.1013413108  0.531
2010 Stuber GD, Hnasko TS, Britt JP, Edwards RH, Bonci A. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8229-33. PMID 20554874 DOI: 10.1523/Jneurosci.1754-10.2010  0.726
2010 Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron. 65: 643-56. PMID 20223200 DOI: 10.1016/J.Neuron.2010.02.012  0.759
2009 Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proceedings of the National Academy of Sciences of the United States of America. 106: 19168-73. PMID 19864633 DOI: 10.1073/Pnas.0910705106  0.568
2007 Hnasko TS, Sotak BN, Palmiter RD. Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12484-8. PMID 18003826 DOI: 10.1523/Jneurosci.3133-07.2007  0.584
2007 Hnasko TS, Hnasko RM, Sotak BN, Kapur RP, Palmiter RD. Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia. Neuroendocrinology. 86: 48-57. PMID 17622754 DOI: 10.1159/000105242  0.594
2007 Robinson S, Rainwater AJ, Hnasko TS, Palmiter RD. Viral restoration of dopamine signaling to the dorsal striatum restores instrumental conditioning to dopamine-deficient mice. Psychopharmacology. 191: 567-78. PMID 17093978 DOI: 10.1007/S00213-006-0579-9  0.661
2006 Hnasko TS, Edwards RH. Synaptic vesicles: half full or half empty? Neuron. 51: 523-4. PMID 16950150 DOI: 10.1016/J.Neuron.2006.08.019  0.507
2006 Hnasko TS, Perez FA, Scouras AD, Stoll EA, Gale SD, Luquet S, Phillips PE, Kremer EJ, Palmiter RD. Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proceedings of the National Academy of Sciences of the United States of America. 103: 8858-63. PMID 16723393 DOI: 10.1073/Pnas.0603081103  0.619
2005 Hnasko TS, Sotak BN, Palmiter RD. Morphine reward in dopamine-deficient mice. Nature. 438: 854-7. PMID 16341013 DOI: 10.1038/Nature04172  0.56
2005 Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science (New York, N.Y.). 310: 683-5. PMID 16254186 DOI: 10.1126/Science.1115524  0.658
2005 Sotak BN, Hnasko TS, Robinson S, Kremer EJ, Palmiter RD. Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding. Brain Research. 1061: 88-96. PMID 16226228 DOI: 10.1016/J.Brainres.2005.08.053  0.721
2004 Hnasko TS, Szczypka MS, Alaynick WA, During MJ, Palmiter RD. A role for dopamine in feeding responses produced by orexigenic agents. Brain Research. 1023: 309-18. PMID 15374756 DOI: 10.1016/J.Brainres.2004.07.051  0.549
2003 Heusner CL, Hnasko TS, Szczypka MS, Liu Y, During MJ, Palmiter RD. Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine. Brain Research. 980: 266-74. PMID 12867267 DOI: 10.1016/S0006-8993(03)02986-X  0.819
Low-probability matches (unlikely to be authored by this person)
2016 Berland C, Cansell C, Hnasko TS, Magnan C, Luquet S. Dietary triglycerides as signaling molecules that influence reward and motivation Current Opinion in Behavioral Sciences. 9: 126-135. DOI: 10.1016/j.cobeha.2016.03.005  0.276
2013 Bui TV, Akay T, Loubani O, Hnasko TS, Jessell TM, Brownstone RM. Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior. Neuron. 78: 191-204. PMID 23583114 DOI: 10.1016/J.Neuron.2013.02.007  0.271
2015 Hnasko TS, Hnasko RM. The Western Blot. Methods in Molecular Biology (Clifton, N.J.). 1318: 87-96. PMID 26160567 DOI: 10.1007/978-1-4939-2742-5_9  0.201
2020 Heston J, Friedman A, Baqai M, Bavafa N, Aron AR, Hnasko TS. Activation of subthalamic nucleus stop circuit disrupts cognitive performance. Eneuro. PMID 32887694 DOI: 10.1523/ENEURO.0159-20.2020  0.185
2023 Tranter MM, Faget L, Hnasko TS, Powell SB, Dillon DG, Barnes SA. Postnatal Phencyclidine-Induced Deficits in Decision Making Are Ameliorated by Optogenetic Inhibition of Ventromedial Orbitofrontal Cortical Glutamate Neurons. Biological Psychiatry Global Open Science. 4: 264-274. PMID 38298783 DOI: 10.1016/j.bpsgos.2023.08.002  0.12
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