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Khalid Iqbal, PhD - Publications

Affiliations: 
Neurochemistry New York State Institute for Basic Research in Disabilities, NY, United States 
Area:
http://www.biomedexperts.com/Profile.bme/1727176/Khalid_Iqbal
Website:
http://www.omr.state.ny.us/ws/ws_ibr_resources.jsp
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Year Citation  Score
2023 Iqbal K. Tau and Alzheimer's disease: Past, present and future. Cytoskeleton (Hoboken, N.J.). 81: 116-121. PMID 38126608 DOI: 10.1002/cm.21822  0.488
2023 Basheer N, Smolek T, Hassan I, Liu F, Iqbal K, Zilka N, Novak P. Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer's disease? From preclinical studies to the clinical trials. Molecular Psychiatry. PMID 37264120 DOI: 10.1038/s41380-023-02113-z  0.385
2023 Liu F, Wu R, Jin N, Chu D, Gu J, Tung YC, Hu Z, Gong CX, Iqbal K. Two simple assays for assessing the seeding activity of proteopathic tau. Frontiers in Aging Neuroscience. 15: 1073774. PMID 37091523 DOI: 10.3389/fnagi.2023.1073774  0.428
2023 Li L, Miao J, Jiang Y, Dai CL, Iqbal K, Liu F, Chu D. Passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xTg-AD mice. Experimental Neurology. 114337. PMID 36717015 DOI: 10.1016/j.expneurol.2023.114337  0.417
2022 Dai CL, Liu F, Iqbal K, Gong CX. Gut Microbiota and Immunotherapy for Alzheimer's Disease. International Journal of Molecular Sciences. 23. PMID 36499564 DOI: 10.3390/ijms232315230  0.309
2022 Baazaoui N, Iqbal K. Alzheimer's Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound. Biomolecules. 12. PMID 36291618 DOI: 10.3390/biom12101409  0.36
2022 Li L, Miao J, Chu D, Jin N, Tung YC, Dai CL, Hu W, Gong CX, Iqbal K, Liu F. Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation. Cns Neuroscience & Therapeutics. PMID 36114722 DOI: 10.1111/cns.13970  0.45
2022 Jin N, Gu J, Wu R, Chu D, Tung YC, Wegiel J, Wisniewski T, Gong CX, Iqbal K, Liu F. Tau seeding activity in various regions of down syndrome brain assessed by two novel assays. Acta Neuropathologica Communications. 10: 132. PMID 36064460 DOI: 10.1186/s40478-022-01436-2  0.429
2022 Hu W, Dai CL, Niu J, Iqbal K. Heightened Tameness and Accelerated Handling-Habituation in 3×Tg-AD Mice on a B6;129 Genetic Background. Journal of Alzheimer's Disease Reports. 6: 245-255. PMID 35719714 DOI: 10.3233/ADR-220007  0.34
2021 Niu J, Iqbal K, Liu F, Hu W. Rats Display Sexual Dimorphism in Phosphorylation of Brain Tau with Age. Journal of Alzheimer's Disease : Jad. PMID 34092647 DOI: 10.3233/JAD-210341  0.301
2021 Pan D, Gu JH, Zhang J, Hu Y, Liu F, Iqbal K, Cekic N, Vocadlo DJ, Dai CL, Gong CX. Thiamme2-G, A Novel O-GlcNAcase Inhibitor, Reduces Tau Hyperphosphorylation and Rescues Cognitive Impairment in Mice. Journal of Alzheimer's Disease : Jad. PMID 33814439 DOI: 10.3233/JAD-201450  0.43
2021 Li L, Shi R, Gu J, Tung YC, Zhou Y, Zhou D, Wu R, Chu D, Jin N, Deng K, Xu J, Gong CX, Iqbal K, Liu F. Alzheimer's disease brain contains tau fractions with differential prion-like activities. Acta Neuropathologica Communications. 9: 28. PMID 33597014 DOI: 10.1186/s40478-021-01127-4  0.428
2021 Wu R, Gu J, Zhou D, Tung YC, Jin N, Chu D, Hu W, Wegiel J, Gong CX, Iqbal K, Liu F. Seeding-Competent Tau in Gray Matter Versus White Matter of Alzheimer's Disease Brain. Journal of Alzheimer's Disease : Jad. PMID 33459649 DOI: 10.3233/JAD-201290  0.411
2020 Wei W, Wang Y, Liu Y, Dai CL, Tung YC, Liu F, Iqbal K. Prenatal to early postnatal neurotrophic treatment prevents Alzheimer-like behavior and pathology in mice. Alzheimer's Research & Therapy. 12: 102. PMID 32854771 DOI: 10.1186/S13195-020-00666-7  0.426
2020 Gu J, Xu W, Jin N, Li L, Zhou Y, Chu D, Gong CX, Iqbal K, Liu F. Truncation of tau selectively facilitates its pathological activities. The Journal of Biological Chemistry. PMID 32737201 DOI: 10.1074/Jbc.Ra120.012587  0.547
2020 Zhao Y, Qian R, Zhang J, Liu F, Iqbal K, Dai CL, Gong CX. Young blood plasma reduces Alzheimer's disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice. Alzheimer's Research & Therapy. 12: 70. PMID 32513253 DOI: 10.1186/S13195-020-00639-W  0.401
2020 Jiang Y, Li L, Dai CL, Zhou R, Gong CX, Iqbal K, Gu JH, Liu F. Effect of Peripheral Insulin Administration on Phosphorylation of Tau in the Brain. Journal of Alzheimer's Disease : Jad. PMID 32417781 DOI: 10.3233/Jad-200147  0.486
2020 Zhou R, Hu W, Dai CL, Gong CX, Iqbal K, Zhu D, Liu F. Expression of Microtubule Associated Protein Tau in Mouse Pancreatic Islets Is Restricted to Autonomic Nerve Fibers. Journal of Alzheimer's Disease : Jad. PMID 32417779 DOI: 10.3233/Jad-200101  0.515
2019 Liu Y, Wei W, Baazaoui N, Liu F, Iqbal K. Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice. Frontiers in Aging Neuroscience. 11: 309. PMID 31803044 DOI: 10.3389/Fnagi.2019.00309  0.376
2019 Iqbal K, Liu F, Gong C, Dai C, Hu W. Why delay in effective treatment for Alzheimer's disease and related conditions. Progress in Molecular Biology and Translational Science. 168: 243-256. PMID 31699318 DOI: 10.1016/bs.pmbts.2019.08.002  0.388
2019 Gu J, Hu W, Tan X, Qu S, Chu D, Gong CX, Iqbal K, Liu F. Elevation of Casein kinase 1ε is associated with TDP-43 and tau pathologies in Alzheimer's disease. Brain Pathology (Zurich, Switzerland). PMID 31376192 DOI: 10.1111/bpa.12775  0.505
2019 Yu Q, Dai CL, Zhang Y, Chen Y, Wu Z, Iqbal K, Liu F, Gong CX. Intranasal Insulin Increases Synaptic Protein Expression and Prevents Anesthesia-Induced Cognitive Deficits Through mTOR-eEF2 Pathway. Journal of Alzheimer's Disease : Jad. PMID 31306126 DOI: 10.3233/Jad-190280  0.335
2019 Miao J, Shi R, Li L, Chen F, Zhou Y, Tung YC, Hu W, Gong CX, Iqbal K, Liu F. Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau . Frontiers in Aging Neuroscience. 11: 34. PMID 30890929 DOI: 10.3389/Fnagi.2019.00034  0.57
2019 Zhang Y, Wu F, Iqbal K, Gong CX, Hu W, Liu F. Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice. Scientific Reports. 9: 3789. PMID 30846870 DOI: 10.1038/S41598-019-40678-4  0.472
2019 Li L, Jiang Y, Hu W, Tung YC, Dai C, Chu D, Gong CX, Iqbal K, Liu F. Pathological Alterations of Tau in Alzheimer's Disease and 3xTg-AD Mouse Brains. Molecular Neurobiology. PMID 30734228 DOI: 10.1007/S12035-019-1507-4  0.548
2019 Gu J, Chu D, Jin N, Iqbal K, Gong C, Liu F. P4-162: CYCLIC AMP-DEPENDENT PROTEIN KINASE PHOSPHORYLATES TDP-43 AND MODULATES ITS FUNCTION IN TAU MRNA PROCESSING Alzheimer's & Dementia. 15: P1336-P1336. DOI: 10.1016/J.Jalz.2019.06.3824  0.421
2019 Liu F, Miao J, Shi R, Li L, Zhou Y, Tung YC, Hu W, Gong C, Iqbal K. P4-152: PATHOLOGICAL TAU FROM ALZHEIMER'S BRAIN INDUCES SITE-SPECIFIC HYPERPHOSPHORYLATION AND SDS- AND REDUCING AGENT-RESISTANT HIGH MOLECULAR WEIGHT AGGREGATION OF TAU IN VIVO Alzheimer's & Dementia. 15: P1333-P1333. DOI: 10.1016/J.Jalz.2019.06.3814  0.479
2019 HU W, Zhang Y, Wu F, Iqbal K, Gong C, Liu F. P2-181: SUBACUTE TO CHRONIC ALZHEIMER-LIKE ALTERATIONS AFTER CONTROLLED CORTICAL IMPACT IN TG/HTAU MICE Alzheimer's & Dementia. 15: P645-P646. DOI: 10.1016/J.Jalz.2019.06.2588  0.321
2018 Gu J, Chen F, Chu D, Lu Y, Iqbal K, Gong CX, Liu F. Rbfox3/NeuN Regulates Alternative Splicing of Tau Exon 10. Journal of Alzheimer's Disease : Jad. PMID 30475774 DOI: 10.3233/Jad-180882  0.453
2018 Hu W, Tung YC, Zhang Y, Liu F, Iqbal K. Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury. Journal of Alzheimer's Disease : Jad. PMID 29889065 DOI: 10.3233/Jad-180177  0.537
2018 Basurto-Islas G, Gu JH, Tung YC, Liu F, Iqbal K. Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia. Journal of Alzheimer's Disease : Jad. PMID 29689717 DOI: 10.3233/Jad-170715  0.507
2018 Gu J, Jin N, Ma D, Chu D, Iqbal K, Gong CX, Liu F. Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain. Journal of Alzheimer's Disease : Jad. 62: 1737-1746. PMID 29614685 DOI: 10.3233/Jad-171047  0.457
2018 Baazaoui N, Iqbal K. A Novel Therapeutic Approach to Treat Alzheimer's Disease by Neurotrophic Support During the Period of Synaptic Compensation. Journal of Alzheimer's Disease : Jad. 62: 1211-1218. PMID 29562539 DOI: 10.3233/Jad-170839  0.415
2018 Gong CX, Liu F, Iqbal K. Multifactorial Hypothesis and Multi-Targets for Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 29562523 DOI: 10.3233/Jad-179921  0.402
2018 Iqbal K, Liu F, Gong CX. Recent developments with tau-based drug discovery. Expert Opinion On Drug Discovery. 1-12. PMID 29493301 DOI: 10.1080/17460441.2018.1445084  0.407
2018 Zhou Y, Shi J, Chu D, Hu W, Guan Z, Gong CX, Iqbal K, Liu F. Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease. Frontiers in Aging Neuroscience. 10: 27. PMID 29472853 DOI: 10.3389/Fnagi.2018.00027  0.577
2018 Jin N, Ma D, Gu J, Shi J, Xu X, Iqbal K, Gong CX, Liu F, Chu D. O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms. Biochemical and Biophysical Research Communications. PMID 29427667 DOI: 10.1016/J.Bbrc.2018.02.053  0.31
2018 Dai CL, Hu W, Tung YC, Liu F, Gong CX, Iqbal K. Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice. Alzheimer's Research & Therapy. 10: 13. PMID 29386065 DOI: 10.1186/S13195-018-0341-7  0.527
2018 Gu J, Wang W, Miao S, Chen F, Wu F, Hu W, Iqbal K, Gong CX, Liu F. Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion. Febs Letters. PMID 29334120 DOI: 10.1002/1873-3468.12976  0.482
2018 Zhou Y, Hu W, Tung YC, Gong C, Iqbal K, Liu F. P1-240: Templation And Propagation Of Tau Pathology By Alzheimer Tau In C57Bl/6 Mice Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.245  0.481
2017 Chen C, Gu J, Basurto-Islas G, Jin N, Wu F, Gong CX, Iqbal K, Liu F. Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease. Scientific Reports. 7: 13478. PMID 29044200 DOI: 10.1038/S41598-017-13791-5  0.576
2017 Hu W, Wu F, Zhang Y, Gong CX, Iqbal K, Liu F. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis. Frontiers in Aging Neuroscience. 9: 311. PMID 29021756 DOI: 10.3389/Fnagi.2017.00311  0.532
2017 Baazaoui N, Iqbal K. Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound. Alzheimer's Research & Therapy. 9: 45. PMID 28655344 DOI: 10.1186/S13195-017-0273-7  0.433
2017 Chen Y, Dai CL, Wu Z, Iqbal K, Liu F, Zhang B, Gong CX. Intranasal Insulin Prevents Anesthesia-Induced Cognitive Impairment and Chronic Neurobehavioral Changes. Frontiers in Aging Neuroscience. 9: 136. PMID 28539885 DOI: 10.3389/Fnagi.2017.00136  0.328
2017 Gu J, Chen F, Iqbal K, Gong CX, Wang X, Liu F. Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: implications for the pathogenesis of tauopathies. The Journal of Biological Chemistry. PMID 28487370 DOI: 10.1074/Jbc.M117.783498  0.505
2017 Kazim SF, Chuang SC, Zhao W, Wong RK, Bianchi R, Iqbal K. Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade. Frontiers in Aging Neuroscience. 9: 71. PMID 28392767 DOI: 10.3389/Fnagi.2017.00071  0.413
2017 Baazaoui N, Iqbal K. Prevention of Amyloid-β and Tau Pathologies, Associated Neurodegeneration, and Cognitive Deficit by Early Treatment with a Neurotrophic Compound. Journal of Alzheimer's Disease : Jad. PMID 28387677 DOI: 10.3233/Jad-170075  0.466
2017 Yin X, Jin N, Shi J, Zhang Y, Wu Y, Gong CX, Iqbal K, Liu F. Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Scientific Reports. 7: 619. PMID 28377597 DOI: 10.1038/S41598-017-00682-Y  0.465
2017 Kazim SF, Blanchard J, Bianchi R, Iqbal K. Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer's-like memory deficits in the Ts65Dn mouse model of Down syndrome. Scientific Reports. 7: 45561. PMID 28368015 DOI: 10.1038/Srep45561  0.414
2017 Gu J, Wu F, Xu W, Shi J, Hu W, Jin N, Qian W, Wang X, Iqbal K, Gong CX, Liu F. TDP-43 suppresses tau expression via promoting its mRNA instability. Nucleic Acids Research. PMID 28335005 DOI: 10.1016/J.Jalz.2016.06.735  0.522
2017 Jin N, Wu Y, Xu W, Gong CX, Iqbal K, Liu F. C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A. Febs Letters. PMID 28267204 DOI: 10.1016/J.Jalz.2017.07.153  0.418
2017 Baazaoui N, Flory M, Iqbal K. Synaptic Compensation as a Probable Cause of Prolonged Mild Cognitive Impairment in Alzheimer's Disease: Implications from a Transgenic Mouse Model of the Disease. Journal of Alzheimer's Disease : Jad. PMID 28222506 DOI: 10.3233/Jad-160845  0.436
2017 Dai CL, Tung YC, Liu F, Gong CX, Iqbal K. Tau passive immunization inhibits not only tau but also Aβ pathology. Alzheimer's Research & Therapy. 9: 1. PMID 28073379 DOI: 10.1186/S13195-016-0227-5  0.542
2017 Baazaoui N, Iqbal K. [O4-06-03]: A NOVEL THERAPEUTIC APPROACH TO TREAT ALZHEIMER's DISEASE DURING THE BRAIN's SELF REPAIR ATTEMPT PERIOD Alzheimer's & Dementia. 13: P1241-P1242. DOI: 10.1016/J.Jalz.2017.07.450  0.369
2017 Iqbal K, Dai C, Liu F, Gong C, Hu W, Tung YC. TAU IMMUNOTHERAPY PREVENTS THE SPREAD AND PROMOTES THE CLEARANCE OF PATHOLOGY IN MICE Alzheimer's & Dementia. 13: P888. DOI: 10.1016/J.Jalz.2017.07.287  0.382
2017 Iqbal K, Kazim SF. [P2-169]: ALZHEIMER's DISEASE IN DOWN SYNDROME CAN BE PREVENTED BY PHARMACOLOGIC TREATMENT DURING PRENATAL TO EARLY POSTNATAL DEVELOPMENT Alzheimer's & Dementia. 13: P671-P671. DOI: 10.1016/J.Jalz.2017.06.820  0.353
2017 Gu J, Wu F, Iqbal K, Gong C, Liu F. [P4-115]: TDP-43 REGULATES ALTERNATIVE SPLICING OF TAU EXON 10: IMPLICATION IN THE PATHOGENESIS OF TAUOPATHIES Alzheimer's & Dementia. 13: P1301-P1301. DOI: 10.1016/J.Jalz.2017.06.1981  0.432
2016 Kazim SF, Iqbal K. Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease. Molecular Neurodegeneration. 11: 50. PMID 27400746 DOI: 10.1186/S13024-016-0119-Y  0.472
2016 Snyder HM, Cardenas-Aguayo Mdel C, Alonso A, Bain L, Iqbal K, Carrillo MC. Alzheimer's disease research in Ibero America. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 749-54. PMID 27288539 DOI: 10.1016/J.Jalz.2016.04.007  0.377
2016 Hu W, Zhang X, Tung YC, Xie S, Liu F, Iqbal K. Hyperphosphorylation determines both the spread and the morphology of tau pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27133892 DOI: 10.1016/J.Jalz.2016.01.014  0.549
2016 Gong CX, Liu F, Iqbal K. O-GlcNAcylation: A regulator of tau pathology and neurodegeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27126545 DOI: 10.1016/J.Jalz.2016.02.011  0.427
2016 Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, ... Iqbal K, et al. Defeating Alzheimer's disease and other dementias: a priority for European science and society. The Lancet. Neurology. 15: 455-532. PMID 26987701 DOI: 10.1016/S1474-4422(16)00062-4  0.414
2016 Zhang Y, Dai CL, Chen Y, Iqbal K, Liu F, Gong CX. Intranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice. Scientific Reports. 6: 21186. PMID 26879001 DOI: 10.1038/Srep21186  0.315
2016 Xie S, Jin N, Gu J, Shi J, Sun J, Chu D, Zhang L, Dai CL, Gu JH, Gong CX, Iqbal K, Liu F. O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease. Aging Cell. PMID 26840030 DOI: 10.1111/acel.12449  0.3
2016 Wang Y, Zhang Y, Hu W, Xie S, Gong CX, Iqbal K, Liu F. Corrigendum: Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation. Scientific Reports. 6: 17241. PMID 26738441 DOI: 10.1038/Srep17241  0.431
2016 Iqbal K, Dai C. Prevention of propagation of tau pathology with antibodies to its amino terminal domain Neurobiology of Aging. 39: S4. DOI: 10.1016/J.Neurobiolaging.2016.01.030  0.357
2016 Iqbal K, Liu F, Hu W, Dai C. O4-04-03: Molecular Mechanism of Tau Spread and Tau Sites to Target for Immunotherapy Alzheimer's & Dementia. 12: P340-P341. DOI: 10.1016/J.Jalz.2016.06.626  0.4
2015 Wang X, Blanchard J, Grundke-Iqbal I, Iqbal K. Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment. Plos One. 10: e0145441. PMID 26697860 DOI: 10.1371/Journal.Pone.0145441  0.63
2015 Iqbal K, Liu F, Gong CX. Tau and neurodegenerative disease: the story so far. Nature Reviews. Neurology. PMID 26635213 DOI: 10.1038/Nrneurol.2015.225  0.555
2015 Wang Y, Zhang Y, Hu W, Xie S, Gong CX, Iqbal K, Liu F. Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation. Scientific Reports. 5: 15709. PMID 26511732 DOI: 10.1038/Srep15709  0.432
2015 Chu D, Tan J, Xie S, Jin N, Yin X, Gong CX, Iqbal K, Liu F. GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner. Journal of Alzheimer's Disease : Jad. PMID 26484916 DOI: 10.3233/Jad-150497  0.364
2015 Khatoon S, Chalbot S, Bolognin S, Puoliväli J, Iqbal K. Elevated Tau Level in Aged Rat Cerebrospinal Fluid Reduced by Treatment with a Neurotrophic Compound. Journal of Alzheimer's Disease : Jad. 47: 557-64. PMID 26401692 DOI: 10.3233/Jad-142799  0.433
2015 Jin N, Yin X, Gu J, Zhang X, Shi J, Qian W, Ji Y, Cao M, Gu X, Ding F, Iqbal K, Gong CX, Liu F. Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. The Journal of Biological Chemistry. 290: 15219-37. PMID 25918155 DOI: 10.1074/Jbc.M115.645507  0.571
2015 Kazim SF, Cardenas-Aguayo Mdel C, Arif M, Blanchard J, Fayyaz F, Grundke-Iqbal I, Iqbal K. Sera from children with autism induce autistic features which can be rescued with a CNTF small peptide mimetic in rats. Plos One. 10: e0118627. PMID 25769033 DOI: 10.1371/Journal.Pone.0118627  0.501
2015 Jin N, Yin X, Yu D, Cao M, Gong CX, Iqbal K, Ding F, Gu X, Liu F. Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. Scientific Reports. 5: 8187. PMID 25641096 DOI: 10.1038/Srep08187  0.533
2015 Wang X, Blanchard J, Tung YC, Grundke-Iqbal I, Iqbal K. Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration, and Cognitive Impairment in Rats. Journal of Alzheimer's Disease : Jad. 45: 423-35. PMID 25589718 DOI: 10.3233/Jad-142403  0.64
2015 Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, et al. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 700-9. PMID 25510383 DOI: 10.1016/J.Jalz.2014.10.007  0.399
2015 Chohan MO, Bragina O, Kazim SF, Statom G, Baazaoui N, Bragin D, Iqbal K, Nemoto E, Yonas H. Enhancement of neurogenesis and memory by a neurotrophic peptide in mild to moderate traumatic brain injury. Neurosurgery. 76: 201-14; discussion 2. PMID 25255260 DOI: 10.1227/Neu.0000000000000577  0.375
2015 Dai CL, Chen X, Kazim SF, Liu F, Gong CX, Grundke-Iqbal I, Iqbal K. Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies. Journal of Neural Transmission (Vienna, Austria : 1996). 122: 607-17. PMID 25233799 DOI: 10.1007/S00702-014-1315-Y  0.665
2015 Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, Wang Y, Chang H, Qian W, Shi J, Iqbal K, Gong CX, Cheng C, Liu F. Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation. Neurobiology of Aging. 36: 188-200. PMID 25219467 DOI: 10.1016/J.Neurobiolaging.2014.07.035  0.397
2015 Yu Y, Li X, Blanchard J, Li Y, Iqbal K, Liu F, Gong CX. Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice. Journal of Neural Transmission (Vienna, Austria : 1996). 122: 593-606. PMID 25113171 DOI: 10.1007/S00702-014-1294-Z  0.431
2015 Hu W, Zhang X, Xie S, Tung YC, Liu F, Iqbal K. Dephosphorylation both diminishes and alters the spread of Alzheimer tau-induced pathology in mice Alzheimers & Dementia. 11: 335. DOI: 10.1016/J.Jalz.2015.08.161  0.461
2015 Iqbal K, Dai C. O3-04-05: Rescue of pathology and cognitive impairment by tau immunotherapy at a moderate to severe stage of the disease in 3xTg-alzheimer's disease mice Alzheimer's & Dementia. 11: P227-P227. DOI: 10.1016/J.Jalz.2015.07.258  0.412
2015 Liu F, Jin N, Yin X, Gu J, Qian W, Gong C, Iqbal K. Regulation of alternative splicing of tau exon 10 by dual-specificity tyrosine-phosphorylation-regulated kinase 1A Alzheimers & Dementia. 11: 203. DOI: 10.1016/J.Jalz.2015.07.197  0.411
2015 Baazaoui N, Iqbal K. P2-038: Preventive effects of a neurotrophic compound on cognition and pathology in 3xTg-AD transgenic mouse model of Alzheimer's disease Alzheimer's & Dementia. 11: P496-P496. DOI: 10.1016/J.Jalz.2015.06.574  0.425
2015 Kazim SF, Chuang S, Zhao W, Iqbal K, Bianchi R. P1-315: Seizure susceptibility and hippocampal network hypersynchrony at a young age in a triple transgenic mouse model of Alzheimer's disease Alzheimer's & Dementia. 11: P477-P477. DOI: 10.1016/J.Jalz.2015.06.530  0.323
2015 Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NHH, Hsiung GYR, Hyman B, Iqbal K, Kaeser SA, Lachno DR, et al. Erratum: CSF biomarker variability in the Alzheimer's Association quality control program (Alzheimer's and Dementia (2013) 9 (251-261)) Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2014.12.004  0.393
2014 Iqbal K, Kazim SF, Bolognin S, Blanchard J. Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer's disease and related neurodegenerative conditions. Neural Regeneration Research. 9: 1518-9. PMID 25317168 DOI: 10.4103/1673-5374.139477  0.456
2014 Arif M, Wei J, Zhang Q, Liu F, Basurto-Islas G, Grundke-Iqbal I, Iqbal K. Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau. The Journal of Biological Chemistry. 289: 27677-91. PMID 25128526 DOI: 10.1074/Jbc.M114.565358  0.693
2014 Kazim SF, Blanchard J, Dai CL, Tung YC, LaFerla FM, Iqbal IG, Iqbal K. Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease. Neurobiology of Disease. 71: 110-30. PMID 25046994 DOI: 10.1016/J.Nbd.2014.07.001  0.491
2014 Basurto-Islas G, Blanchard J, Tung YC, Fernandez JR, Voronkov M, Stock M, Zhang S, Stock JB, Iqbal K. Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease. Neurobiology of Aging. 35: 2701-12. PMID 25034344 DOI: 10.1016/J.Neurobiolaging.2014.06.012  0.488
2014 Chen Y, Zhao Y, Dai CL, Liang Z, Run X, Iqbal K, Liu F, Gong CX. Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice. Experimental Neurology. 261: 610-9. PMID 24918340 DOI: 10.1016/J.Expneurol.2014.06.004  0.387
2014 Chen Y, Run X, Liang Z, Zhao Y, Dai CL, Iqbal K, Liu F, Gong CX. Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice. Frontiers in Aging Neuroscience. 6: 100. PMID 24910612 DOI: 10.3389/Fnagi.2014.00100  0.505
2014 Bolognin S, Buffelli M, Puoliväli J, Iqbal K. Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound. Neurobiology of Aging. 35: 2134-46. PMID 24702821 DOI: 10.1016/J.Neurobiolaging.2014.02.017  0.327
2014 Zhao Y, Gu JH, Dai CL, Liu Q, Iqbal K, Liu F, Gong CX. Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice. Frontiers in Aging Neuroscience. 6: 10. PMID 24575038 DOI: 10.3389/Fnagi.2014.00010  0.45
2014 Iqbal K, Liu F, Gong CX. Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles. Biochemical Pharmacology. 88: 631-9. PMID 24418409 DOI: 10.1016/j.bcp.2014.01.002  0.322
2014 Arif M, Kazim SF, Grundke-Iqbal I, Garruto RM, Iqbal K. Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam. Proceedings of the National Academy of Sciences of the United States of America. 111: 1144-9. PMID 24395787 DOI: 10.1073/Pnas.1322614111  0.66
2014 Iqbal K, Gong CX, Liu F. Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease. Expert Opinion On Therapeutic Targets. 18: 307-18. PMID 24387228 DOI: 10.1517/14728222.2014.870156  0.508
2014 Wang X, Blanchard J, Grundke-Iqbal I, Wegiel J, Deng HX, Siddique T, Iqbal K. Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection. Acta Neuropathologica. 127: 243-56. PMID 24136402 DOI: 10.1007/S00401-013-1175-9  0.627
2014 Chen C, Jin N, Qian W, Liu W, Tan X, Ding F, Gu X, Iqbal K, Gong CX, Zuo J, Liu F. Cyclic AMP-dependent protein kinase enhances SC35-promoted Tau exon 10 inclusion. Molecular Neurobiology. 49: 615-24. PMID 24037441 DOI: 10.1007/S12035-013-8542-3  0.525
2014 Chen Y, Liang Z, Tian Z, Blanchard J, Dai CL, Chalbot S, Iqbal K, Liu F, Gong CX. Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice. Molecular Neurobiology. 49: 547-62. PMID 23996345 DOI: 10.1007/S12035-013-8539-Y  0.476
2014 Iqbal K. The Merits of Activation of Protein Phosphatase-2A as a Therapeutic Approach to Alzheimer Disease and Related Tauopathies Neurobiology of Aging. 35. DOI: 10.1016/J.Neurobiolaging.2014.01.069  0.395
2014 Iqbal K, Bolognin S, Kazim SF. O2-06-04: A NOVEL PHARMACOLOGIC THERAPEUTIC APPROACH TO ALZHEIMER DISEASE AND COGNITIVE AGING Alzheimer's & Dementia. 10: P175-P175. DOI: 10.1016/J.Jalz.2014.04.189  0.328
2013 Iqbal K, Flory M, Soininen H. Clinical symptoms and symptom signatures of Alzheimer's disease subgroups. Journal of Alzheimer's Disease : Jad. 37: 475-81. PMID 24002184 DOI: 10.3233/Jad-130899  0.44
2013 Iqbal K, Gong CX, Liu F. Hyperphosphorylation-induced tau oligomers. Frontiers in Neurology. 4: 112. PMID 23966973 DOI: 10.3389/fneur.2013.00112  0.498
2013 Qian W, Jin N, Shi J, Yin X, Jin X, Wang S, Cao M, Iqbal K, Gong CX, Liu F. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression. Journal of Alzheimer's Disease : Jad. 37: 529-38. PMID 23948904 DOI: 10.3233/Jad-130824  0.525
2013 Iqbal K, Bolognin S, Wang X, Basurto-Islas G, Blanchard J, Tung YC. Animal models of the sporadic form of Alzheimer's disease: focus on the disease and not just the lesions. Journal of Alzheimer's Disease : Jad. 37: 469-74. PMID 23948903 DOI: 10.3233/Jad-130827  0.467
2013 Dai CL, Shi J, Chen Y, Iqbal K, Liu F, Gong CX. Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT). The Journal of Biological Chemistry. 288: 23875-83. PMID 23843462 DOI: 10.1074/Jbc.M112.445148  0.348
2013 Basurto-Islas G, Grundke-Iqbal I, Tung YC, Liu F, Iqbal K. Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease. The Journal of Biological Chemistry. 288: 17495-507. PMID 23640887 DOI: 10.1074/Jbc.M112.446070  0.682
2013 Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, et al. CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 251-61. PMID 23622690 DOI: 10.1016/J.Jalz.2013.01.010  0.421
2013 Jin N, Qian W, Yin X, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease. Nucleic Acids Research. 41: 3240-56. PMID 23341039 DOI: 10.1093/nar/gks1227  0.549
2013 Cardenas-Aguayo Mdel C, Kazim SF, Grundke-Iqbal I, Iqbal K. Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures. Plos One. 8: e53596. PMID 23320097 DOI: 10.1371/Journal.Pone.0053596  0.526
2013 Chen Y, Liang Z, Blanchard J, Dai CL, Sun S, Lee MH, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse). Molecular Neurobiology. 47: 711-25. PMID 23150171 DOI: 10.1007/S12035-012-8375-5  0.615
2013 Wang JZ, Xia YY, Grundke-Iqbal I, Iqbal K. Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. Journal of Alzheimer's Disease : Jad. 33: S123-39. PMID 22710920 DOI: 10.3233/Jad-2012-129031  0.692
2013 Basurto-Islas G, Iqbal K. P1-409: A molecular mechanism by which acidosis of the brain can lead to Alzheimer's disease Alzheimer's & Dementia. 9: P307-P307. DOI: 10.1016/J.Jalz.2013.05.637  0.429
2013 Liu F, Chen C, Jin N, Gu J, Basurto-Islas G, Qian W, Gong C, Iqbal K. P4-049: Upregulation of casein kinase 1 epsilon may be involved in tau pathology in Alzheimer's disease brain Alzheimer's & Dementia. 9: P720-P720. DOI: 10.1016/J.Jalz.2013.05.1437  0.431
2013 Arif M, Grundke-Iqbal I, Iqbal K. P3-042: β-N-Methylamino-L-alanine could be involved in Alzheimer's neurofibrillary pathology in amyotrophic lateral sclerosis-Parkinsonism dementia complex Alzheimer's & Dementia. 9: P566-P566. DOI: 10.1016/J.Jalz.2013.05.1111  0.559
2013 Kazim SF, Blanchard J, Dai C, Tung Y, Grundke-Iqbal I, Iqbal K. O3-13-02: Chronic treatment with a CNTF-derived peptide reverses dendritic and synaptic plasticity deficits, cognitive impairment and tau pathology in an Alzheimer's disease mouse model Alzheimer's & Dementia. 9: P548-P548. DOI: 10.1016/J.Jalz.2013.04.310  0.583
2012 Chen Y, Tian Z, Liang Z, Sun S, Dai CL, Lee MH, LaFerla FM, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease. Plos One. 7: e51432. PMID 23236499 DOI: 10.1371/Journal.Pone.0051432  0.598
2012 Gong CX, Liu F, Iqbal K. O-GlcNAc cycling modulates neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 109: 17319-20. PMID 23047690 DOI: 10.1073/Pnas.1215395109  0.447
2012 Liu Y, Li X, Yu Y, Shi J, Liang Z, Run X, Li Y, Dai CL, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain. Plos One. 7: e43724. PMID 22928023 DOI: 10.1371/Journal.Pone.0043724  0.515
2012 Yin X, Jin N, Gu J, Shi J, Zhou J, Gong CX, Iqbal K, Grundke-Iqbal I, Liu F. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. The Journal of Biological Chemistry. 287: 30497-506. PMID 22767602 DOI: 10.1074/Jbc.M112.355412  0.642
2012 Shi J, Wu S, Dai CL, Li Y, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. Diverse regulation of AKT and GSK-3β by O-GlcNAcylation in various types of cells. Febs Letters. 586: 2443-50. PMID 22687243 DOI: 10.1016/J.Febslet.2012.05.063  0.539
2012 Gu J, Shi J, Wu S, Jin N, Qian W, Zhou J, Iqbal IG, Iqbal K, Gong CX, Liu F. Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10. Febs Letters. 586: 2239-44. PMID 22677170 DOI: 10.1016/J.Febslet.2012.05.046  0.479
2012 Yu Y, Zhang L, Li X, Run X, Liang Z, Li Y, Liu Y, Lee MH, Grundke-Iqbal I, Iqbal K, Vocadlo DJ, Liu F, Gong CX. Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. Plos One. 7: e35277. PMID 22536363 DOI: 10.1371/Journal.Pone.0035277  0.676
2012 Bolognin S, Blanchard J, Wang X, Basurto-Islas G, Tung YC, Kohlbrenner E, Grundke-Iqbal I, Iqbal K. An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide. Acta Neuropathologica. 123: 133-51. PMID 22083255 DOI: 10.1007/S00401-011-0908-X  0.605
2012 Ding S, Shi J, Qian W, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A. Neurobiology of Aging. 33: 1389-99. PMID 21215488 DOI: 10.1016/J.Neurobiolaging.2010.11.021  0.631
2012 Iqbal K, Grundke-Iqbal I. 37 Promise and feasibility of inhibition of Tau's abnormal hyperphosphorylation Neurobiology of Aging. 33: S16-S17. DOI: 10.1016/J.Neurobiolaging.2012.01.055  0.449
2012 Jin N, Qian W, Yin X, Iqbal K, Grundke-Iqbal I, Gong C, Liu F. P2-081: CREB regulates the expression of neuronal glucose transporter 3: A mechanism leading to impaired brain glucose uptake in Alzheimer's disease Alzheimer's & Dementia. 8: P292-P292. DOI: 10.1016/J.Jalz.2012.05.785  0.546
2012 Liu F, Jin N, Shi J, Qian W, Yin X, Grundke-Iqbal I, Iqbal K, Gong C. O1-07-06: Truncation of GSK-3beta by calpain I contributes to the hyperphosphorylation of tau in the Alzheimer's brain Alzheimer's & Dementia. 8: P98-P98. DOI: 10.1016/J.Jalz.2012.05.244  0.612
2012 Grundke-Iqbal I, Bolognin S, Wang X, Blanchard J, Iqbal K. P4-224: Rescue of cognitive impairment and neuronal plasticity with a neurotrophic peptide in a rat model of sporadic Alzheimer's disease Alzheimer's & Dementia. 8: P713-P714. DOI: 10.1016/J.Jalz.2012.05.1929  0.55
2012 Shi J, Gu J, Grundke-Iqbal I, Iqbal K, Liu F, Gong C. P4-045: Cerebral ischemia-induced elevation of O-GlcNAcylation causes AKT inhibition and apoptosis Alzheimer's & Dementia. 8: P651-P651. DOI: 10.1016/J.Jalz.2012.05.1746  0.465
2012 Gong C, Liu F, Grundke-Iqbal I, Iqbal K. F3-02-02: O-GlcNAcylated tau: A link between impaired glucose metabolism and neurodegeneration in Alzheimer's disease Alzheimer's & Dementia. 8: P423-P423. DOI: 10.1016/J.Jalz.2012.05.1127  0.58
2011 Blanchard J, Bolognin S, Chohan MO, Rabe A, Iqbal K, Grundke-Iqbal I. Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome. Journal of Neuropathology and Experimental Neurology. 70: 1070-9. PMID 22082658 DOI: 10.1097/Nen.0B013E318236E9Ad  0.511
2011 Iqbal K, Grundke-Iqbal I. Opportunities and challenges in developing Alzheimer disease therapeutics. Acta Neuropathologica. 122: 543-9. PMID 21959585 DOI: 10.1007/S00401-011-0878-Z  0.615
2011 Rockenstein E, Ubhi K, Doppler E, Novak P, Moessler H, Li B, Blanchard J, Grundke-Iqbal I, Iqbal K, Mante M, Adame A, Crews L, Masliah E. Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic mice. Journal of Alzheimer's Disease : Jad. 27: 743-52. PMID 21860085 DOI: 10.3233/Jad-2011-110914  0.545
2011 Arnaud L, Chen S, Liu F, Li B, Khatoon S, Grundke-Iqbal I, Iqbal K. Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET. Febs Letters. 585: 2653-9. PMID 21806989 DOI: 10.1016/J.Febslet.2011.07.020  0.606
2011 Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, ... ... Iqbal K, et al. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 386-395.e6. PMID 21784349 DOI: 10.1016/J.Jalz.2011.05.2243  0.441
2011 Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. The Journal of Pathology. 225: 54-62. PMID 21598254 DOI: 10.1002/Path.2912  0.611
2011 Chalbot S, Zetterberg H, Blennow K, Fladby T, Andreasen N, Grundke-Iqbal I, Iqbal K. Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 25: 505-15. PMID 21471645 DOI: 10.3233/Jad-2011-101959  0.622
2011 Qian W, Liang H, Shi J, Jin N, Grundke-Iqbal I, Iqbal K, Gong CX, Liu F. Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic Acids Research. 39: 6161-71. PMID 21470964 DOI: 10.1093/nar/gkr195  0.615
2011 Shi J, Qian W, Yin X, Iqbal K, Grundke-Iqbal I, Gu X, Ding F, Gong CX, Liu F. Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. The Journal of Biological Chemistry. 286: 14639-48. PMID 21367856 DOI: 10.1074/Jbc.M110.204453  0.689
2011 Qian W, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. Splicing factor SC35 promotes tau expression through stabilization of its mRNA. Febs Letters. 585: 875-80. PMID 21333649 DOI: 10.1016/J.Febslet.2011.02.017  0.637
2011 Wegiel J, Kaczmarski W, Barua M, Kuchna I, Nowicki K, Wang KC, Wegiel J, Yang SM, Frackowiak J, Mazur-Kolecka B, Silverman WP, Reisberg B, Monteiro I, de Leon M, Wisniewski T, ... ... Iqbal K, et al. Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. Journal of Neuropathology and Experimental Neurology. 70: 36-50. PMID 21157379 DOI: 10.1097/Nen.0B013E318202Bfa1  0.442
2011 Qian W, Yin X, Hu W, Shi J, Gu J, Grundke-Iqbal I, Iqbal K, Gong CX, Liu F. Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 23: 617-27. PMID 21157033 DOI: 10.3233/Jad-2010-100987  0.671
2011 Chohan MO, Li B, Blanchard J, Tung YC, Heaney AT, Rabe A, Iqbal K, Grundke-Iqbal I. Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide. Neurobiology of Aging. 32: 1420-34. PMID 19767127 DOI: 10.1016/J.Neurobiolaging.2009.08.008  0.491
2011 Bolognin S, Blanchard J, Wang X, Grundke-Iqbal I, Iqbal K. P4-252: Chronic treatment with an 11-mer CNTF peptide rescues synaptic deficit and cognitive impairment in a rat model of sporadic Alzheimer's disease Alzheimer's & Dementia. 7: S794-S794. DOI: 10.1016/J.Jalz.2011.05.2277  0.531
2011 Blanchard J, Iqbal K, Grundke-Iqbal I. P3-433: Improvement of cognition by enhancing neurogenesis and neuronal plasticity with a CNTF peptidergic compound Alzheimer's & Dementia. 7: S654-S654. DOI: 10.1016/J.Jalz.2011.05.1877  0.571
2011 del Carmen Cardenas-Aguayo M, Grundke-Iqbal I, Iqbal K. P3-423: Neurogenic and neuroprotective effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures Alzheimer's & Dementia. 7: S651-S651. DOI: 10.1016/J.Jalz.2011.05.1867  0.488
2011 Shi J, Qian W, Yin X, Grundke-Iqbal I, Iqbal K, Gong C, Liu F. P3-139: Differential regulation of the alternative splicing of tau exon 10 by protein kinase A isoforms Alzheimer's & Dementia. 7: S560-S560. DOI: 10.1016/J.Jalz.2011.05.1579  0.604
2011 Basurto-Islas G, Grundke-Iqbal I, Iqbal K. P2-302: Asparagine Endopeptidase (AEP) is activated in Alzheimer's disease brain and induces I2PP2A cleavage Alzheimer's & Dementia. 7: S407-S407. DOI: 10.1016/J.Jalz.2011.05.1180  0.606
2010 Blanchard J, Chohan MO, Li B, Liu F, Iqbal K, Grundke-Iqbal I. Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice. Journal of Alzheimer's Disease : Jad. 21: 1185-95. PMID 20952820 DOI: 10.3233/Jad-2010-1000069  0.508
2010 Iqbal K, Grundke-Iqbal I. Alzheimer's disease, a multifactorial disorder seeking multitherapies. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 420-4. PMID 20813343 DOI: 10.1016/J.Jalz.2010.04.006  0.612
2010 Blanchard J, Wanka L, Tung YC, Cárdenas-Aguayo Mdel C, LaFerla FM, Iqbal K, Grundke-Iqbal I. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice. Acta Neuropathologica. 120: 605-21. PMID 20697724 DOI: 10.1007/S00401-010-0734-6  0.615
2010 Iqbal K, Liu F, Gong CX, Grundke-Iqbal I. Tau in Alzheimer disease and related tauopathies. Current Alzheimer Research. 7: 656-64. PMID 20678074 DOI: 10.2174/156720510793611592  0.681
2010 Alonso AD, Di Clerico J, Li B, Corbo CP, Alaniz ME, Grundke-Iqbal I, Iqbal K. Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. The Journal of Biological Chemistry. 285: 30851-60. PMID 20663882 DOI: 10.1074/Jbc.M110.110957  0.621
2010 Iqbal K, Wang X, Blanchard J, Liu F, Gong CX, Grundke-Iqbal I. Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial. Biochemical Society Transactions. 38: 962-6. PMID 20658985 DOI: 10.1042/Bst0380962  0.661
2010 Wang X, Blanchard J, Kohlbrenner E, Clement N, Linden RM, Radu A, Grundke-Iqbal I, Iqbal K. The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4420-32. PMID 20651003 DOI: 10.1096/Fj.10-158477  0.647
2010 Li B, Wanka L, Blanchard J, Liu F, Chohan MO, Iqbal K, Grundke-Iqbal I. Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice. Febs Letters. 584: 3359-65. PMID 20600002 DOI: 10.1016/J.Febslet.2010.06.025  0.499
2010 Chalbot S, Zetterberg H, Blennow K, Fladby T, Grundke-Iqbal I, Iqbal K. Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: a biomarker of blood-cerebrospinal fluid barrier permeability. Neuroscience Letters. 478: 179-83. PMID 20470866 DOI: 10.1016/J.Neulet.2010.05.012  0.528
2010 Gong CX, Grundke-Iqbal I, Iqbal K. Targeting tau protein in Alzheimer's disease. Drugs & Aging. 27: 351-65. PMID 20450234 DOI: 10.2165/11536110-000000000-00000  0.683
2010 Zilka N, Korenova M, Kovacech B, Iqbal K, Novak M. CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy. Acta Neuropathologica. 119: 679-87. PMID 20379729 DOI: 10.1007/S00401-010-0680-3  0.516
2010 Qian W, Shi J, Yin X, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. Journal of Alzheimer's Disease : Jad. 19: 1221-9. PMID 20308788 DOI: 10.3233/Jad-2010-1317  0.666
2010 Blanchard J, Iqbal K, Grundke-Iqbal I. S4-03-06: Reversal Of Cognitive Impairment By Pharmacologic Neuroregeneration: A Novel Therapeutic Approach Alzheimer's & Dementia. 6: e14-e14. DOI: 10.1016/J.Jalz.2010.08.045  0.465
2010 Yin X, Shi J, Grundke-Iqbal I, Iqbal K, Gong C, Liu F. P1-350: Overexpression of Dyrk1A dysregulates the alternative splicing of tau exon 10 Alzheimer's & Dementia. 6: S274-S274. DOI: 10.1016/J.Jalz.2010.05.903  0.592
2010 Liu F, Shi J, Qian W, Yin X, Grundke-Iqbal I, Iqbal K, Gong C. Truncation of GSK-3β by activated calpain I in Alzheimer brain enhances its biological activity Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.887  0.552
2010 Blanchard J, Iqbal K, Grundke-Iqbal I. P1-186: Chronic treatment with a CNTF peptide enhances neuronal plasticity and alleviates cognitive impairment in 3xTgAD mice Alzheimer's & Dementia. 6: S227-S228. DOI: 10.1016/J.Jalz.2010.05.736  0.479
2010 Wang X, Blanchard J, Grundke-Iqbal I, Iqbal K. S5-01-05: A novel etiopathogenic mechanism and a disease-relevant non-transgenic rat model of Alzheimer's disease Alzheimer's & Dementia. 6: S167-S167. DOI: 10.1016/J.Jalz.2010.05.520  0.557
2010 Iqbal K, Wang X, Blanchard J, Grundke-Iqbal I. O4-04-04: A protein phosphatase-2A-based etiopathogenic mechanism of Alzheimer's disease Alzheimer's & Dementia. 6: S155-S155. DOI: 10.1016/J.Jalz.2010.05.484  0.57
2010 Grundke-Iqbal I, Blanchard J, Chohan MO, Rabe A, Iqbal K. P3-355: Chronic treatment with a CNTF peptide restores neurogenesis and alleviates memory deficit in Ts65Dn mice Alzheimer's & Dementia. 6: S556-S556. DOI: 10.1016/J.Jalz.2010.05.1897  0.464
2010 Li X, Yu Y, Blanchard J, Liu Y, Iqbal K, Grundke-Iqbal I, Gong C. P3-340: Molecular basis of cognitive improvement of pioglitazone and rosiglitazone Alzheimer's & Dementia. 6: S552-S552. DOI: 10.1016/J.Jalz.2010.05.1841  0.458
2010 Shi J, Yin X, Iqbal K, Grundke-Iqbal I, Liu F, Gong C. P2-308: Regulation of Akt by O-GlcNAcylation in various cell types: implication in Alzheimer's Disease Alzheimer's & Dementia. 6: S403-S404. DOI: 10.1016/J.Jalz.2010.05.1359  0.572
2010 Gong C, Liu Y, Deng Y, Liu F, Grundke-Iqbal I, Iqbal K. P2-245: Dysregulation of brain insulin signaling: A mechanistic link between diabetes and Alzheimer's disease Alzheimer's & Dementia. 6: S386-S386. DOI: 10.1016/J.Jalz.2010.05.1294  0.547
2009 Chalbot S, Zetterberg H, Blennow K, Fladby T, Grundke-Iqbal I, Iqbal K. Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease. Clinical Chemistry. 55: 2171-9. PMID 19850632 DOI: 10.1373/Clinchem.2009.130286  0.546
2009 Deng Y, Li B, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX. Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. The American Journal of Pathology. 175: 2089-98. PMID 19815707 DOI: 10.2353/Ajpath.2009.090157  0.631
2009 Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease. Journal of Neurochemistry. 111: 242-9. PMID 19659459 DOI: 10.1111/J.1471-4159.2009.06320.X  0.644
2009 Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M. Novel therapeutic strategies for neurodegenerative disease. Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society. 9: 103-9. PMID 19604333 DOI: 10.1111/J.1479-8301.2009.00289.X  0.661
2009 Liu F, Shi J, Tanimukai H, Gu J, Gu J, Grundke-Iqbal I, Iqbal K, Gong CX. Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain : a Journal of Neurology. 132: 1820-32. PMID 19451179 DOI: 10.1093/Brain/Awp099  0.668
2009 Liang Z, Liu F, Iqbal K, Grundke-Iqbal I, Gong CX. Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage. Journal of Alzheimer's Disease : Jad. 17: 531-9. PMID 19363259 DOI: 10.3233/Jad-2009-1069  0.697
2009 Run X, Liang Z, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX. Anesthesia induces phosphorylation of tau. Journal of Alzheimer's Disease : Jad. 16: 619-26. PMID 19276556 DOI: 10.3233/Jad-2009-1003  0.679
2009 Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I. Mechanisms of tau-induced neurodegeneration. Acta Neuropathologica. 118: 53-69. PMID 19184068 DOI: 10.1007/S00401-009-0486-3  0.666
2009 Yu Y, Run X, Liang Z, Li Y, Liu F, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX. Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases. Journal of Neurochemistry. 108: 1480-94. PMID 19183272 DOI: 10.1111/J.1471-4159.2009.05882.X  0.69
2009 Grundke-Iqbal I, Chohan MO, Li B, Blanchard J, Wanka L, Iqbal K. O3-06-08: Development of neurotrophic peptides for enhancement of neurogenesis and associated behavioral improvement Alzheimer's & Dementia. 5: P139-P139. DOI: 10.1016/J.Jalz.2009.05.473  0.465
2009 Iqbal K, Wang X, Blanchard J, Grundke-Iqbal I. O3-05-03: Overexpression of inhibitor-1 or -2 of protein phosphatase-2A causes abnormal hyperphosphorylation of tau and cognitive impairment in the rat Alzheimer's & Dementia. 5: P135-P135. DOI: 10.1016/J.Jalz.2009.05.459  0.561
2009 Liu F, Shi J, Qian W, Yin X, Grundke-Iqbal I, Iqbal K, Gong C. O3-05-01: Truncation and activation of Dyrk1A in Alzheimer's disease brain by activated calpain I Alzheimer's & Dementia. 5: P134-P135. DOI: 10.1016/J.Jalz.2009.05.457  0.587
2009 Rockenstein E, Doppler E, Moessler H, Li B, Blanchard J, Grundke-Iqbal I, Iqbal K, Mante M, Adame A, Masliah E. P4-030: Development of neuropeptides that promote neurogenesis in models of Alzheimer's and Parkinson's disease Alzheimer's & Dementia. 5: P440-P440. DOI: 10.1016/J.Jalz.2009.04.900  0.556
2009 Liang Z, Liu F, Iqbal K, Grundke-Iqbal I, Gong C. P3-178: Excitotoxic damage deregulates tau phosphorylation: Implication to Alzheimer's disease Alzheimer's & Dementia. 5: P396-P396. DOI: 10.1016/J.Jalz.2009.04.1052  0.66
2008 Iqbal K, Chohan MO, Grundke-Iqbal I. Stratification of patients is the way to go to develop neuroprotective/disease-modifying drugs for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 15: 339-45. PMID 18953118 DOI: 10.3233/Jad-2008-15215  0.598
2008 Gong CX, Iqbal K. Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. Current Medicinal Chemistry. 15: 2321-8. PMID 18855662  0.469
2008 Alonso AC, Li B, Grundke-Iqbal I, Iqbal K. Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies. Current Alzheimer Research. 5: 375-84. PMID 18690834 DOI: 10.2174/156720508785132307  0.636
2008 Iqbal K, Alonso Adel C, Grundke-Iqbal I. Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly. Journal of Alzheimer's Disease : Jad. 14: 365-70. PMID 18688085 DOI: 10.3233/Jad-2008-14402  0.631
2008 Shi J, Zhang T, Zhou C, Chohan MO, Gu X, Wegiel J, Zhou J, Hwang YW, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome. The Journal of Biological Chemistry. 283: 28660-9. PMID 18658135 DOI: 10.1074/Jbc.M802645200  0.638
2008 Liu F, Liang Z, Wegiel J, Hwang YW, Iqbal K, Grundke-Iqbal I, Ramakrishna N, Gong CX. Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3224-33. PMID 18509201 DOI: 10.1096/Fj.07-104539  0.658
2008 Liang Z, Liu F, Iqbal K, Grundke-Iqbal I, Wegiel J, Gong CX. Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. Journal of Alzheimer's Disease : Jad. 13: 295-302. PMID 18430997 DOI: 10.3233/Jad-2008-13307  0.699
2008 Chen S, Li B, Grundke-Iqbal I, Iqbal K. I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. The Journal of Biological Chemistry. 283: 10513-21. PMID 18245083 DOI: 10.1074/Jbc.M709852200  0.634
2008 Wang XC, Zhang YC, Chatterjie N, Grundke-Iqbal I, Iqbal K, Wang JZ. Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells. Neurochemical Research. 33: 1138-44. PMID 18231852 DOI: 10.1007/S11064-007-9563-Y  0.548
2008 Iqbal K, Grundke-Iqbal I. Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention. Journal of Cellular and Molecular Medicine. 12: 38-55. PMID 18194444 DOI: 10.1111/j.1582-4934.2008.00225.x  0.674
2008 Liu Y, Liu F, Iqbal K, Grundke-Iqbal I, Gong CX. Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease. Febs Letters. 582: 359-64. PMID 18174027 DOI: 10.1016/J.Febslet.2007.12.035  0.611
2008 Li B, Yamamori H, Tatebayashi Y, Shafit-Zagardo B, Tanimukai H, Chen S, Iqbal K, Grundke-Iqbal I. Failure of neuronal maturation in Alzheimer disease dentate gyrus. Journal of Neuropathology and Experimental Neurology. 67: 78-84. PMID 18091557 DOI: 10.1097/Nen.0B013E318160C5Db  0.558
2008 Deng Y, Li B, Liu F, Iqbal K, Grundke-Iqbal I, Brandt R, Gong CX. Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 138-45. PMID 17687114 DOI: 10.1096/Fj.07-8309Com  0.568
2008 Grundke-Iqbal I, Chohan MO, Li B, Blanchard J, Iqbal K. O4-04-08: Improvement of cognition with a neurogenic/neurotrophic peptide Alzheimer's & Dementia. 4: T193-T193. DOI: 10.1016/J.Jalz.2008.05.534  0.467
2008 Liu Y, Liu F, Iqbal K, Grundke-Iqbal I, Gong C. O4-02-05: Molecular mechanism by which type 2 diabetes mellitus increases the risk for Alzheimer's disease Alzheimer's & Dementia. 4: T187-T187. DOI: 10.1016/J.Jalz.2008.05.513  0.515
2008 Gong C, Liu F, Liu Y, Deng Y, Grundke-Iqbal I, Iqbal K. O2-05-08: Protein O-Glcnacylation: A novel mechanism involved in Alzheimer's disease Alzheimer's & Dementia. 4: T143-T143. DOI: 10.1016/J.Jalz.2008.05.347  0.541
2008 Novak P, Rockenstein E, Tatebayashi Y, Moessler H, Iqbal K, Masliah E. P2-450: Cerebrolysin stimulates neurogenesis in the dentate gyrus: A basis for neuronal replacement therapy in Alzheimer's disease? Alzheimer's & Dementia. 4: T505-T505. DOI: 10.1016/J.Jalz.2008.05.2496  0.347
2008 Chalbot S, Blennow K, Grundke-Iqbal I, Iqbal K. P3-063: CSF phospholipase A2 activity is a biomarker of blood brain barrier permeability but not Alzheimer's disease Alzheimer's & Dementia. 4: T536-T536. DOI: 10.1016/J.Jalz.2008.05.1627  0.588
2008 Li B, Chohan MO, Blanchard J, Iqbal K, Grundke-Iqbal I. P2-445: Enhancement of dentate gyrus neurogenesis and associated memory by a neurotrophic peptide Alzheimer's & Dementia. 4: T504-T504. DOI: 10.1016/J.Jalz.2008.05.1524  0.473
2008 Liang H, Shi J, Iqbal K, Grundke-Iqbal I, Gong C, Liu F. P2-155: Phosphorylation of SC35 by Dyrk1A inhibits its promotion of tau exon 10 inclusion Alzheimer's & Dementia. 4: T416-T416. DOI: 10.1016/J.Jalz.2008.05.1229  0.613
2008 Yin X, Jin N, Shi J, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. P2-147: Modulation of SRp55-regulated alternative splicing of tau exon 10 by Dyrk1A Alzheimer's & Dementia. 4: T413-T413. DOI: 10.1016/J.Jalz.2008.05.1220  0.568
2008 Shi J, Gu Q, Wang W, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. P2-145: Regulation of ASF-mediated alternative splicing of tau exon 10 by PKA Alzheimer's & Dementia. 4: T413-T413. DOI: 10.1016/J.Jalz.2008.05.1218  0.596
2008 Liang Z, Liu F, Iqbal K, Grundke-Iqbal I, Wegiel J, Gong C. P2-142: Decreased protein phosphatase 2A in Down syndrome brain: A cause of neurofibrillary degeneration Alzheimer's & Dementia. 4: T412-T412. DOI: 10.1016/J.Jalz.2008.05.1215  0.545
2007 Sevcik J, Skrabana R, Dvorsky R, Csokova N, Iqbal K, Novak M. X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease. Febs Letters. 581: 5872-8. PMID 18061582 DOI: 10.1016/J.Febslet.2007.11.067  0.456
2007 Liu F, Li B, Tung EJ, Grundke-Iqbal I, Iqbal K, Gong CX. Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation. The European Journal of Neuroscience. 26: 3429-36. PMID 18052981 DOI: 10.1111/J.1460-9568.2007.05955.X  0.643
2007 Liang Z, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. Journal of Neurochemistry. 103: 2462-70. PMID 17908236 DOI: 10.1111/J.1471-4159.2007.04942.X  0.615
2007 Iqbal K, Grundke-Iqbal I. Developing pharmacological therapies for Alzheimer disease. Cellular and Molecular Life Sciences : Cmls. 64: 2234-44. PMID 17604997 DOI: 10.1007/s00018-007-7221-9  0.629
2007 Yamamori H, Khatoon S, Grundke-Iqbal I, Blennow K, Ewers M, Hampel H, Iqbal K. Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification. Neuroscience Letters. 418: 186-9. PMID 17400380 DOI: 10.1016/J.Neulet.2007.03.022  0.613
2007 Li B, Chohan MO, Grundke-Iqbal I, Iqbal K. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta Neuropathologica. 113: 501-11. PMID 17372746 DOI: 10.1007/S00401-007-0207-8  0.663
2007 Kovacech B, Kontsekova E, Zilka N, Novak P, Skrabana R, Filipcik P, Iqbal K, Novak M. A novel monoclonal antibody DC63 reveals that inhibitor 1 of protein phosphatase 2A is preferentially nuclearly localised in human brain. Febs Letters. 581: 617-22. PMID 17266954 DOI: 10.1016/J.Febslet.2007.01.015  0.512
2007 Wang JZ, Grundke-Iqbal I, Iqbal K. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. The European Journal of Neuroscience. 25: 59-68. PMID 17241267 DOI: 10.1111/J.1460-9568.2006.05226.X  0.693
2007 Chen H, Tung YC, Li B, Iqbal K, Grundke-Iqbal I. Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis. Neurobiology of Aging. 28: 1148-62. PMID 16859812 DOI: 10.1016/J.Neurobiolaging.2006.05.036  0.532
2007 Iqbal K, Grundke-Iqbal I. Alzheimer subgroups: Towards effective drug development Future Neurology. 2: 3-6. DOI: 10.2217/14796708.2.1.3  0.5
2007 Iqbal K, Grundke-Iqbal I. O2-01-06: Inhibition of more than one tau kinase might be required for prevention of Alzheimer disease Alzheimer's & Dementia. 3: S183-S184. DOI: 10.1016/J.Jalz.2007.04.049  0.637
2007 Iqbal K, Grundke-Iqbal I. Tau pathology as a target in Alzheimer's therapeutics Pharmacological Mechanisms in Alzheimer's Therapeutics. 223-237. DOI: 10.1007/978-0-387-71522-3_14  0.479
2006 Grundke-Iqbal I, Rolkova G, Konstekova E, Iqbal K. Biological markers in Alzheimer's disease. Bratislavskã© Lekã¡Rske Listy. 107: 359-65. PMID 17262988  0.58
2006 Pevalova M, Filipcik P, Novak M, Avila J, Iqbal K. Post-translational modifications of tau protein. Bratislavskã© Lekã¡Rske Listy. 107: 346-53. PMID 17262986  0.484
2006 Iqbal K, Novak M. From tangles to tau protein. Bratislavskã© Lekã¡Rske Listy. 107: 341-2. PMID 17262984  0.356
2006 Sengupta A, Grundke-Iqbal I, Iqbal K. Regulation of phosphorylation of tau by protein kinases in rat brain. Neurochemical Research. 31: 1473-80. PMID 17120162 DOI: 10.1016/S0197-4580(00)82474-4  0.625
2006 Liu F, Liang Z, Shi J, Yin D, El-Akkad E, Grundke-Iqbal I, Iqbal K, Gong CX. PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners. Febs Letters. 580: 6269-74. PMID 17078951 DOI: 10.1016/J.Febslet.2006.10.033  0.599
2006 Gong CX, Liu F, Grundke-Iqbal I, Iqbal K. Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target. Journal of Biomedicine & Biotechnology. 2006: 31825. PMID 17047304 DOI: 10.1155/Jbb/2006/31825  0.678
2006 Sengupta A, Novak M, Grundke-Iqbal I, Iqbal K. Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level. Febs Letters. 580: 5925-33. PMID 17045592 DOI: 10.1016/J.Febslet.2006.09.060  0.663
2006 Chohan MO, Iqbal K. From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 10: 81-7. PMID 16988485 DOI: 10.3233/Jad-2006-10112  0.304
2006 Iqbal K, Grundke-Iqbal I. Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective. Journal of Alzheimer's Disease : Jad. 9: 219-42. PMID 16914861  0.645
2006 Chohan MO, Khatoon S, Iqbal IG, Iqbal K. Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine. Febs Letters. 580: 3973-9. PMID 16806196 DOI: 10.1016/J.Febslet.2006.06.021  0.538
2006 Alonso Adel C, Li B, Grundke-Iqbal I, Iqbal K. Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proceedings of the National Academy of Sciences of the United States of America. 103: 8864-9. PMID 16735465 DOI: 10.1073/Pnas.0603214103  0.645
2006 Gong CX, Liu F, Grundke-Iqbal I, Iqbal K. Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation. Journal of Alzheimer's Disease : Jad. 9: 1-12. PMID 16627930 DOI: 10.3233/Jad-2006-9101  0.661
2006 Zhou XW, Li X, Bjorkdahl C, Sjogren MJ, Alafuzoff I, Soininen H, Grundke-Iqbal I, Iqbal K, Winblad B, Pei JJ. Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiology of Disease. 22: 657-68. PMID 16513361 DOI: 10.1016/J.Nbd.2006.01.006  0.675
2006 Rahman A, Grundke-Iqbal I, Iqbal K. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of Neural Transmission (Vienna, Austria : 1996). 113: 219-30. PMID 15959850 DOI: 10.1007/S00702-005-0313-5  0.666
2006 Dai C, HU W, Liu F, Gong C, Iqbal K. O1-06-03: IMMUNOTHERAPY-TARGETING TAU BLOCKS TAU PATHOLOGY INDUCED BY ALZHEIMER'S HYPERPHOSPHORYLATED TAU IN TRIPLE-TRANSGENIC AD MICE Alzheimer's & Dementia. 14: P231-P231. DOI: 10.1016/J.Jalz.2018.06.2362  0.507
2006 Hu W, Tung YC, Zhang Y, Liu F, Iqbal K. P3-185: INVOLVEMENT OF ACTIVATION OF ASPARAGINYL ENDOPEPTIDASE IN TAU HYPERPHOSPHORYLATION IN TRAUMATIC BRAIN INJURY Alzheimer's & Dementia. 14: P1138-P1138. DOI: 10.1016/J.Jalz.2018.06.1543  0.377
2006 Liu F, Zhou Y, Shi J, Li L, Jiang Y, Chu D, HU W, Gong C, Iqbal K. P3-183: RELEVANCE OF PHOSPHORYLATION AND TRUNCATION OF TAU TO THE ETIOPATHOGENESIS OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1137-P1137. DOI: 10.1016/J.Jalz.2018.06.1541  0.531
2006 Yamamori H, Grundke-Iqabal I, Iqbal K. P2-150: Detection of phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients: An ultrasensitive bienzyme-substrate-recycle ELISA Alzheimer's & Dementia. 2: S277-S277. DOI: 10.1016/J.Jalz.2006.05.988  0.48
2006 Iqbal K, Khatoon S, Yamamori H, Grundke-Iqbal I. S4-01-01 Alzheimer's & Dementia. 2: S68. DOI: 10.1016/J.Jalz.2006.05.263  0.671
2006 Gong C, Liu F, Grundke-Iqbal I, Iqbal K. S3-03-01: O-glycosylation regulates phosphorylation of tau:A novel mechanism leading to neurofibrillarydegeneration in Alzheimer disease Alzheimer's & Dementia. 2: S48-S48. DOI: 10.1016/J.Jalz.2006.05.174  0.648
2006 Grundke-Iqbal I, Li B, Chohan MO, Tung YC, Iqbal K. P3-337: Enhancement of neurogenesis by peptides: A promising therapeutic approach Alzheimer's & Dementia. 2: S473-S474. DOI: 10.1016/J.Jalz.2006.05.1607  0.466
2006 Chen S, Grundke-Iqbal I, Iqbal K. P3-329: I1 PP2A and I2 PP2A affect tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A Alzheimer's & Dementia. 2: S471-S471. DOI: 10.1016/J.Jalz.2006.05.1599  0.597
2006 Liang Z, Liu F, Hwang Y, Wegiel J, Iqbal K, Grundke-Iqbal I, Gong C. P3-304: Mnb/Dyrk1A primes phosphorylation of tau at several phosphorylation sites by GSK-3β Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1574  0.586
2006 Liu R, Björkdahl C, Zhou X, Alafuzoff I, Soininen H, Bogdanovic N, Iqbal K, Grundke-Iqbal I, Winblad BW, Wang J, Pei J. P3-300: Increased tyrosine 307 phosphorylation of protein phosphatase-2A correlates with tau associated pathologies in Alzheimer’s disease Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1569  0.634
2006 Khatoon S, Grundke-Iqbal I, Iqbal K. P3-292: High throughput screen assay to develop drugs for inhibition of abnormal hyperphosphorylation of tau Alzheimer's & Dementia. 2: S461-S461. DOI: 10.1016/J.Jalz.2006.05.1561  0.525
2006 Liu F, Grundke-Iqbal I, Iqbal K, Gong C. P3-248: Activation of calpain I in Alzheimer disease brain negatively regulates CREB Alzheimer's & Dementia. 2: S448-S448. DOI: 10.1016/J.Jalz.2006.05.1517  0.61
2006 Alonso AD, Li B, Grundke-Iqbal I, Iqbal K. O2-01-02: Treat abnormal hyperphosphorylation and not aggregation of tau Alzheimer's & Dementia. 2: S29-S30. DOI: 10.1016/J.Jalz.2006.05.103  0.575
2005 del C Alonso A, Iqbal K. Tau-induced neurodegeneration: a clue to its mechanism. Journal of Alzheimer's Disease : Jad. 8: 223-6. PMID 16340080 DOI: 10.3233/Jad-2005-8301  0.438
2005 Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. The European Journal of Neuroscience. 22: 1942-50. PMID 16262633 DOI: 10.1111/J.1460-9568.2005.04391.X  0.69
2005 Iqbal K, Flory M, Khatoon S, Soininen H, Pirttila T, Lehtovirta M, Alafuzoff I, Blennow K, Andreasen N, Vanmechelen E, Grundke-Iqbal I. Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers. Annals of Neurology. 58: 748-57. PMID 16247771 DOI: 10.1002/Ana.20639  0.622
2005 Wiltfang J, Lewczuk P, Riederer P, Grünblatt E, Hock C, Scheltens P, Hampel H, Vanderstichele H, Iqbal K, Galasko D, Lannfelt L, Otto M, Esselmann H, Henkel AW, Kornhuber J, et al. Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 6: 69-84. PMID 16156480 DOI: 10.1080/15622970510029786  0.438
2005 Liu F, Grundke-Iqbal I, Iqbal K, Oda Y, Tomizawa K, Gong CX. Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. The Journal of Biological Chemistry. 280: 37755-62. PMID 16150694 DOI: 10.1074/Jbc.M507475200  0.615
2005 Ruben GC, Wang JZ, Iqbal K, Grundke-Iqbal I. Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation. Microscopy Research and Technique. 67: 175-95. PMID 16104003 DOI: 10.1002/Jemt.20197  0.497
2005 Ashford JW, Atwood CS, Blass JP, Bowen RL, Finch CE, Iqbal K, Joseph JA, Perry G. What is aging? What is its role in Alzheimer's disease? What can we do about it? Journal of Alzheimer's Disease : Jad. 7: 247-53; discussion 2. PMID 16006669 DOI: 10.3233/Jad-2005-7308  0.345
2005 Iqbal K, Grundke-Iqbal I. Pharmacological approaches of neurofibrillary degeneration. Current Alzheimer Research. 2: 335-41. PMID 15974899 DOI: 10.2174/1567205054367810  0.656
2005 Tanimukai H, Grundke-Iqbal I, Iqbal K. Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. The American Journal of Pathology. 166: 1761-71. PMID 15920161 DOI: 10.1016/S0002-9440(10)62486-8  0.67
2005 Rahman A, Grundke-Iqbal I, Iqbal K. Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1. Neurochemical Research. 30: 277-87. PMID 15895832 DOI: 10.1007/S11064-005-2483-9  0.644
2005 Iqbal K, Grundke-Iqbal I. Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies. Acta Neuropathologica. 109: 25-31. PMID 15645264 DOI: 10.1007/S00401-004-0951-Y  0.653
2005 Tsujio I, Zaidi T, Xu J, Kotula L, Grundke-Iqbal I, Iqbal K. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. Febs Letters. 579: 363-72. PMID 15642345 DOI: 10.1016/J.Febslet.2004.11.097  0.616
2005 Sun L, Wang X, Liu S, Wang Q, Wang J, Bennecib M, Gong CX, Sengupta A, Grundke-Iqbal I, Iqbal K. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. Febs Letters. 579: 251-8. PMID 15620722 DOI: 10.1016/J.Febslet.2004.11.083  0.651
2005 Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, Tanimukai H, Grundke-Iqbal I. Tau pathology in Alzheimer disease and other tauopathies. Biochimica Et Biophysica Acta. 1739: 198-210. PMID 15615638 DOI: 10.1016/J.Bbadis.2004.09.008  0.656
2005 Chohan MO, Haque N, Alonso A, El-Akkad E, Grundke-Iqbal I, Grover A, Iqbal K. Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 1035-47. PMID 15583961 DOI: 10.1007/s00702-004-0241-9  0.613
2005 Huang Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain. Neuroscience Letters. 373: 115-8. PMID 15567564 DOI: 10.1016/J.Neulet.2004.09.074  0.529
2005 Liu F, Iqbal K, Grundke-Iqbal I, Rossie S, Gong CX. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. The Journal of Biological Chemistry. 280: 1790-6. PMID 15546861 DOI: 10.1074/Jbc.M410775200  0.696
2005 Gong CX, Liu F, Grundke-Iqbal I, Iqbal K. Post-translational modifications of tau protein in Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 813-38. PMID 15517432 DOI: 10.1007/s00702-004-0221-0  0.654
2005 Iqbal K, Flory M, Khatoon S, Soininen H, Pirttila T, Lehtovirta M, Blennow K, Andreasen N, Vanmechelen E, Grundke-Iqbal I. [O1-04-05]: Subgroups of Alzheimer disease based on cerebrospinal fluid levels of molecular markers Alzheimer's & Dementia. 1: S87-S87. DOI: 10.1016/J.Jalz.2005.06.304  0.551
2004 Huang Y, Tanimukai H, Liu F, Iqbal K, Grundke-Iqbal I, Gong CX. Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain. The European Journal of Neuroscience. 20: 3489-97. PMID 15610181 DOI: 10.1111/J.1460-9568.2004.03852.X  0.588
2004 Haque N, Gong CX, Sengupta A, Iqbal K, Grundke-Iqbal I. Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells. Brain Research. Molecular Brain Research. 129: 163-70. PMID 15469892 DOI: 10.1016/J.Molbrainres.2004.07.001  0.614
2004 Liu SJ, Zhang JY, Li HL, Fang ZY, Wang Q, Deng HM, Gong CX, Grundke-Iqbal I, Iqbal K, Wang JZ. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. The Journal of Biological Chemistry. 279: 50078-88. PMID 15375165 DOI: 10.1074/jbc.M406109200  0.636
2004 Iqbal K, Grundke-Iqbal I. Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies. Current Drug Targets. 5: 495-502. PMID 15270196 DOI: 10.2174/1389450043345254  0.662
2004 Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 10804-9. PMID 15249677 DOI: 10.1073/Pnas.0400348101  0.675
2004 Tanimukai H, Grundke-Iqbal I, Iqbal K. Inhibitors of protein phosphatase-2A: topography and subcellular localization. Brain Research. Molecular Brain Research. 126: 146-56. PMID 15249138 DOI: 10.1016/J.Molbrainres.2004.04.003  0.538
2004 Skrabana R, Kontsek P, Mederlyova A, Iqbal K, Novak M. Folding of Alzheimer's core PHF subunit revealed by monoclonal antibody 423. Febs Letters. 568: 178-82. PMID 15196943 DOI: 10.1016/J.Febslet.2004.04.098  0.405
2004 Alonso Adel C, Mederlyova A, Novak M, Grundke-Iqbal I, Iqbal K. Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. The Journal of Biological Chemistry. 279: 34873-81. PMID 15190058 DOI: 10.1074/Jbc.M405131200  0.598
2004 Li L, Sengupta A, Haque N, Grundke-Iqbal I, Iqbal K. Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. Febs Letters. 566: 261-9. PMID 15147906 DOI: 10.1016/J.Febslet.2004.04.047  0.622
2004 Tatebayashi Y, Haque N, Tung YC, Iqbal K, Grundke-Iqbal I. Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport. Journal of Cell Science. 117: 1653-63. PMID 15075227 DOI: 10.1242/Jcs.01018  0.629
2004 Gong CX, Liu F, Wu G, Rossie S, Wegiel J, Li L, Grundke-Iqbal I, Iqbal K. Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5. Journal of Neurochemistry. 88: 298-310. PMID 14690518 DOI: 10.1111/J.1471-4159.2004.02147.X  0.694
2004 Khatoon S, Grundke-Iqbal I, Iqbal K. P4-425 High throughput screen assays of inhibition of PP-2A catalyzed dephosphorylation of abnormally hyperphosphorylated tau by I1PP2A and I2PP2A Neurobiology of Aging. 25: S595. DOI: 10.1016/S0197-4580(04)81981-X  0.544
2004 Rolkova G, Hanusovska E, Zilka N, Sutovsky S, Garay R, Iqbal K, Novak M. P4-108 First indentified case of familial Alzheimer's disease in Europe associated with mutation (VAL717PHE) in the APP gene Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81666-X  0.35
2004 Rahman A, Grundke-Iqbal I, Iqbal K. P3-264 A novel phosphoseryl/phosphothreonyl protein phosphatase activity that might be involved in the abnormal hyperphosphorylation of tau Neurobiology of Aging. 25: S430. DOI: 10.1016/S0197-4580(04)81414-3  0.618
2004 Liu F, Iqbal K, Grundke-Iqbal I, Gong C. P3-263 Phosphorylation of tau is regulated by O-Glcnacylation Neurobiology of Aging. 25: S429. DOI: 10.1016/S0197-4580(04)81413-1  0.594
2004 Chohan MO, Alonso A, Haque N, El-Akkad E, Grundke-Iqbal I, Grover A, Iqbal K. P3-254 Hyperphosphorylation induced self-assembly of murine tau: a comparison with human tau Neurobiology of Aging. 25: S427. DOI: 10.1016/S0197-4580(04)81404-0  0.589
2004 Wang J, Liu S, Zhang J, Li H, Fang Z, Wang Q, Gong C, Grundke-Iqbal I, Iqbal K. P3-251 Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81401-5  0.593
2004 An W, Cowburn RF, Bjorkdahl C, Braak H, Alafuzoff I, Iqbal K, Grundke-Iqbal I, Winblad B. P3-246 Association of P70 S6 kinase with neurofibrillary degeneration in Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81396-4  0.596
2004 Chen S, Grundke-Iqbal I, Iqbal K. P3-240 I1PP2A and I2PP2A interact with the catalytic subunit of protein phosphatase 2A Neurobiology of Aging. 25: S423. DOI: 10.1016/S0197-4580(04)81390-3  0.492
2004 Tanimukai H, Grundke-Iqbal I, Iqbal K. P3-224 Inhibitors of protein phosphatase-2A colocalize with the abnormally hyperphosphorylated tau in Alzheimer disease Neurobiology of Aging. 25: S418-S419. DOI: 10.1016/S0197-4580(04)81374-5  0.64
2004 Vechterova L, Kontsek P, Skrabana R, Kontsekova E, Iqbal K, Novak M. P3-222 Truncated tau is intimately involved in formation of PHF Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81372-1  0.441
2004 Li B, Liu F, Grundke-Iqbal I, Iqbal K. P2-129 Tau and a cell culture model of microtubule stability Neurobiology of Aging. 25: S261. DOI: 10.1016/S0197-4580(04)80876-5  0.554
2004 Haque N, Gong C, Sengupta A, Iqbal K, Grundke-Iqbal I. P2-128 Regulation of microtubule-associated proteins, protein kinases, and protein phosphatases during differentiation of SY5Y cells Neurobiology of Aging. 25: S261. DOI: 10.1016/S0197-4580(04)80875-3  0.554
2004 Chen H, Grundke-Iqbal I, Iqbal K. P1-358 Enhancement of neurogenesis by neurotrophic factors: a therapeutic approach to Alzheimer disease Neurobiology of Aging. 25: S200. DOI: 10.1016/S0197-4580(04)80670-5  0.556
2004 Huang Y, Iqbal K, Grundke-Iqbal I, Tanimukai H, Liu F, Gong C. P1-267 Alterations of glycoproteins in Alzheimer disease brain Neurobiology of Aging. 25: S172. DOI: 10.1016/S0197-4580(04)80580-3  0.607
2004 Pei JJ, An W, Cowburn RF, Grundke-Iqbal I, Iqbal K, Winblad B. S5-02-05 Involvement of aberrant regulation of PI3K and MAPK cascades in AD TAU phosphorylation Neurobiology of Aging. 25: S90. DOI: 10.1016/S0197-4580(04)80307-5  0.66
2004 Grundke-Iqbal I, Chen H, Li B, Tung Y, Tatebayashi Y, Iqbal K. O4-05-04 Regeneration of the brain: a promising approach to neurodegeneration and disorders of learning and memory Neurobiology of Aging. 25: S83. DOI: 10.1016/S0197-4580(04)80283-5  0.483
2004 Gong C, Liu F, Xu L, Wang J, Grundke-Iqbal I, Iqbal K. O2-05-06 Impaired glucose uptake/metabolism contributes to hyperphosphorylation of tau via reduction of O-GLCnacylation: a novel mechanism involved in Alzheimer disease Neurobiology of Aging. 25: S42. DOI: 10.1016/S0197-4580(04)80140-4  0.56
2004 Iqbal K, Grundke-Iqbal I. S2-04-02 Treatment of Alzheimer and other tauopathies by inhibition of neurofibrillary degeneration Neurobiology of Aging. 25: S30. DOI: 10.1016/S0197-4580(04)80098-8  0.577
2004 del Carmen Alonso A, Mederlyova A, Novak M, Grundke-Iqbal I, Iqbal K. S1-04-04 Mutations in tau gene lead to neurodegeneration by making tau a more favorable substrate for abnormal hyperphosphorylation Neurobiology of Aging. 25: S7-S8. DOI: 10.1016/S0197-4580(04)80025-3  0.594
2003 Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Pei JJ, Tanimukai H, Tsujio I, Wang JZ, Grundke-Iqba I. Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays. Journal of Molecular Neuroscience : Mn. 20: 425-9. PMID 14501027 DOI: 10.1385/Jmn:20:3:425  0.571
2003 Pei JJ, Gong CX, An WL, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K. Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease. The American Journal of Pathology. 163: 845-58. PMID 12937126 DOI: 10.1016/S0002-9440(10)63445-1  0.644
2003 An WL, Cowburn RF, Li L, Braak H, Alafuzoff I, Iqbal K, Iqbal IG, Winblad B, Pei JJ. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. The American Journal of Pathology. 163: 591-607. PMID 12875979 DOI: 10.1016/S0002-9440(10)63687-5  0.518
2003 Hua Q, He RQ, Haque N, Qu MH, del Carmen Alonso A, Grundke-Iqbal I, Iqbal K. Microtubule associated protein tau binds to double-stranded but not single-stranded DNA. Cellular and Molecular Life Sciences : Cmls. 60: 413-21. PMID 12678504 DOI: 10.1007/S000180300034  0.6
2003 Gong CX, Wang JZ, Iqbal K, Grundke-Iqbal I. Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neuroscience Letters. 340: 107-10. PMID 12668248 DOI: 10.1016/S0304-3940(03)00096-X  0.608
2003 Pei JJ, Khatoon S, An WL, Nordlinder M, Tanaka T, Braak H, Tsujio I, Takeda M, Alafuzoff I, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K. Role of protein kinase B in Alzheimer's neurofibrillary pathology. Acta Neuropathologica. 105: 381-92. PMID 12624792 DOI: 10.1007/S00401-002-0657-Y  0.702
2003 Tatebayashi Y, Lee MH, Li L, Iqbal K, Grundke-Iqbal I. The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease. Acta Neuropathologica. 105: 225-32. PMID 12557008 DOI: 10.1007/S00401-002-0636-3  0.577
2002 Wang J, Wang X, Liu R, Wang Q, Grundke-Iqbal I, Iqbal K. In vitro analysis of tau phosphorylation sites and its biological activity. Chinese Medical Sciences Journal = Chung-Kuo I Hsã¼Eh K'O Hsã¼Eh Tsa Chih / Chinese Academy of Medical Sciences. 17: 13-6. PMID 12894878  0.618
2002 Pei JJ, Braak H, An WL, Winblad B, Cowburn RF, Iqbal K, Grundke-Iqbal I. Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. Brain Research. Molecular Brain Research. 109: 45-55. PMID 12531514 DOI: 10.1016/S0169-328X(02)00488-6  0.648
2002 Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Tsujio I, Grundke-Iqbal I. Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration. Journal of Neural Transmission. Supplementum. 309-19. PMID 12456074  0.662
2002 Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX. Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5. Neuroscience. 115: 829-37. PMID 12435421 DOI: 10.1016/S0306-4522(02)00510-9  0.659
2002 Liu F, Iqbal K, Grundke-Iqbal I, Gong CX. Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. Febs Letters. 530: 209-14. PMID 12387894 DOI: 10.1016/S0014-5793(02)03487-7  0.663
2002 Iqbal K, Grundke-Iqbal I. Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease. Journal of Alzheimer's Disease : Jad. 4: 235-8. PMID 12226542 DOI: 10.3233/Jad-2002-4313  0.574
2002 Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Pei JJ, Tsujio I, Wang JZ, Grundke-Iqbal I. Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion. Journal of Molecular Neuroscience : Mn. 19: 95-9. PMID 12212801 DOI: 10.1007/S12031-002-0017-3  0.694
2002 Pei JJ, Braak H, Gong CX, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration. Acta Neuropathologica. 104: 369-76. PMID 12200623 DOI: 10.1007/S00401-002-0565-1  0.694
2002 Hu YY, He SS, Wang X, Duan QH, Grundke-Iqbal I, Iqbal K, Wang J. Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. The American Journal of Pathology. 160: 1269-78. PMID 11943712 DOI: 10.1016/S0002-9440(10)62554-0  0.659
2002 Hu YY, He SS, Wang XC, Duan QH, Khatoon S, Iqbal K, Grundke-Iqbal I, Wang JZ. Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients. Neuroscience Letters. 320: 156-60. PMID 11852185 DOI: 10.1016/S0304-3940(02)00047-2  0.548
2002 Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Merkle RK, Gong CX. Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease. Febs Letters. 512: 101-6. PMID 11852060 DOI: 10.1016/S0014-5793(02)02228-7  0.712
2001 Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration. Journal of Alzheimer's Disease : Jad. 3: 41-48. PMID 12214071 DOI: 10.3233/Jad-2001-3107  0.672
2001 Vijayan S, El-Akkad E, Grundke-Iqbal I, Iqbal K. A pool of beta-tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain. Febs Letters. 509: 375-81. PMID 11749959 DOI: 10.1016/S0014-5793(01)03201-X  0.62
2001 Wang J, Tung YC, Wang Y, Li XT, Iqbal K, Grundke-Iqbal I. Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells. Febs Letters. 507: 81-7. PMID 11682063 DOI: 10.1016/S0014-5793(01)02944-1  0.604
2001 Alonso AD, Zaidi T, Novak M, Barra HS, Grundke-Iqbal I, Iqbal K. Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein. The Journal of Biological Chemistry. 276: 37967-73. PMID 11495914 DOI: 10.1074/jbc.M105365200  0.654
2001 Cheng LY, Wang JZ, Gong CX, Pei JJ, Zaidi T, Grundke-Iqbal I, Iqbal K. Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue nonbinding phosphatase activities. Neurochemical Research. 26: 425-38. PMID 11495355 DOI: 10.1023/A:1010963401453  0.547
2001 Alonso A, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K. Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proceedings of the National Academy of Sciences of the United States of America. 98: 6923-8. PMID 11381127 DOI: 10.1073/Pnas.121119298  0.594
2001 Sato Y, Naito Y, Grundke-Iqbal I, Iqbal K, Endo T. Analysis of N-glycans of pathological tau: possible occurrence of aberrant processing of tau in Alzheimer's disease. Febs Letters. 496: 152-60. PMID 11356201 DOI: 10.1016/S0014-5793(01)02421-8  0.68
2001 Gong CX, Lidsky T, Wegiel J, Grundke-Iqbal I, Iqbal K. Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain. Brain Research. Brain Research Protocols. 6: 134-40. PMID 11223412 DOI: 10.1016/S1385-299X(00)00046-5  0.655
2001 Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. Febs Letters. 490: 15-22. PMID 11172803 DOI: 10.1016/S0014-5793(01)02127-5  0.601
2000 Wang J, Wei Z, Wang Q, Grundke-Iqbal I, Iqbal K. [Association of microtubule promoting and binding activity of tau with its phosphorylation sites]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 22: 120-3. PMID 12903511  0.617
2000 Iqbal K, Grundke-Iqbal I. Alzheimer disease is multifactorial and heterogeneous. Neurobiology of Aging. 21: 901-2; discussion 90. PMID 11124439 DOI: 10.1016/S0197-4580(00)00191-3  0.591
2000 Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. Febs Letters. 485: 87-93. PMID 11086171 DOI: 10.1016/S0014-5793(00)02203-1  0.642
2000 Iqbal K, Alonso AD, Gondal JA, Gong CX, Haque N, Khatoon S, Sengupta A, Wang JZ, Grundke-Iqbal I. Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach. Journal of Neural Transmission. Supplementum. 59: 213-22. PMID 10961432 DOI: 10.1007/978-3-7091-6781-6_22  0.651
2000 Tsujio I, Tanaka T, Kudo T, Nishikawa T, Shinozaki K, Grundke-Iqbal I, Iqbal K, Takeda M. Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation. Febs Letters. 469: 111-7. PMID 10708767 DOI: 10.1016/S0014-5793(00)01234-5  0.592
2000 Cheng LY, Wang JZ, Gong CX, Pei JJ, Zaidi T, Grundke-Iqbal I, Iqbal K. Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue binding phosphatases. Neurochemical Research. 25: 107-20. PMID 10685610  0.556
2000 Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. The Journal of Biological Chemistry. 275: 5535-44. PMID 10681533 DOI: 10.1074/Jbc.275.8.5535  0.704
2000 Gong CX, Wegiel J, Lidsky T, Zuck L, Avila J, Wisniewski HM, Grundke-Iqbal I, Iqbal K. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Brain Research. 853: 299-309. PMID 10640627 DOI: 10.1016/S0006-8993(99)02294-5  0.598
2000 He S, Hu Y, Grundke-Iqbal I, Iqbal K, Wang J. Development of an ultrasensitive elisa-double enzyme amplification assay and quantitation of total and abnormally hyperphosphorylated taus in cerebrospinal fluid Neurobiology of Aging. 21: 228. DOI: 10.1016/S0197-4580(00)83359-X  0.54
2000 Hu Y, Wang J, Iqbal K, Inge G, He S. Quantitative neurofilament protein assay in Alzheimer disease cerebrospinal fluid Neurobiology of Aging. 21: 228. DOI: 10.1016/S0197-4580(00)83357-6  0.408
2000 Grundke-Iqbal I, Tatebayashi Y, Gong C, Zhong J, Haque N, Iqbal K. Role of protein kinases, protein phosphatases and extracellular signals in the abnormal hyperphosphorylation of tau Neurobiology of Aging. 21: 210. DOI: 10.1016/S0197-4580(00)83273-X  0.595
2000 Wang J, Tung YC, Wang Y, Iqbal K, Grundke-Iqbal I. Hyperphosphorylation and accumulation of neurofilament protein subunits in Alzheimer disease brain Neurobiology of Aging. 21: 273. DOI: 10.1016/S0197-4580(00)83181-4  0.627
2000 Tatebayashi Y, Lee MH, Iqbal K, Grundke-Iqbal I. The peptidergic antidementia drug cerebrolysin increases neurogenesis in the adult rat dentate gyrus and improves spatial learning and memory Neurobiology of Aging. 21: 42. DOI: 10.1016/S0197-4580(00)82863-8  0.444
2000 Khatoon S, Soininen H, Lehtovirta M, Alafuzoff II, Vanmechelen EJ, Grundke-Iqbal I, Iqbal K. Subgroups of Alzheimer disease based on levels of CSF tau, ubiquitin and Aβ1−42 Neurobiology of Aging. 21: 31. DOI: 10.1016/S0197-4580(00)82814-6  0.642
2000 Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong C. Glycosylation of tau protein occurs earlier than its hyperphosphorylation in Alzheimer's disease Neurobiology of Aging. 21: 16. DOI: 10.1016/S0197-4580(00)82749-9  0.664
2000 Gong C, Lidsky T, Wegiel J, Grundke-Iqbal I, Iqbal K. Metabolically active rat brain slices as a model for studying neurofibrillary degeneration of Alzheimer's disease Neurobiology of Aging. 21: 10. DOI: 10.1016/S0197-4580(00)82722-0  0.592
2000 Vijayan S, Grundke-Iqbal I, Iqbal K. Abnormal hyperphosphorylation of non-tau proteins in Alzheimer's disease brain Neurobiology of Aging. 21: 150. DOI: 10.1016/S0197-4580(00)82475-6  0.671
2000 Haque N, Zhong J, Iqbal K, Grundke-Iqbal I. Overexpression of tau associates with differentiation of neuronal cells in culture Neurobiology of Aging. 21: 110. DOI: 10.1016/S0197-4580(00)82291-5  0.537
2000 del C. Alonso A, Zaidi T, Grundke-Iqbal I, Iqbal K. In vitro self assembly of abnormally hyperphosphorylated tau into PHF-like structures Neurobiology of Aging. 21: 197. DOI: 10.1016/S0197-4580(00)82228-9  0.555
1999 Grundke-Iqbal I, Iqbal K. Tau pathology generated by overexpression of tau. The American Journal of Pathology. 155: 1781-5. PMID 10595905 DOI: 10.1016/S0002-9440(10)65494-6  0.636
1999 Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. Journal of Neuropathology and Experimental Neurology. 58: 1010-9. PMID 10499443 DOI: 10.1097/00005072-199909000-00011  0.601
1999 Haque N, Tanaka T, Iqbal K, Grundke-Iqbal I. Regulation of expression, phosphorylation and biological activity of tau during differentiation in SY5Y cells. Brain Research. 838: 69-77. PMID 10446318 DOI: 10.1016/S0006-8993(99)01622-4  0.647
1999 Zhong J, Iqbal K, Grundke-Iqbal I. Hyperphosphorylated tau in SY5Y cells: similarities and dissimilarities to abnormally hyperphosphorylated tau from Alzheimer disease brain. Febs Letters. 453: 224-8. PMID 10403408 DOI: 10.1016/S0014-5793(99)00715-2  0.649
1999 Tatebayashi Y, Iqbal K, Grundke-Iqbal I. Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5245-54. PMID 10377336 DOI: 10.1523/Jneurosci.19-13-05245.1999  0.62
1998 Iqbal K, Grundke-Iqbal I. Tau phosphatase activity as a therapeutic target for AD. Drug News & Perspectives. 11: 10-4. PMID 15616638  0.652
1998 Sironi JJ, Yen SH, Gondal JA, Wu Q, Grundke-Iqbal I, Iqbal K. Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK. Febs Letters. 436: 471-5. PMID 9801171 DOI: 10.1016/S0014-5793(98)01185-5  0.656
1998 Wang JZ, Wu Q, Smith A, Grundke-Iqbal I, Iqbal K. Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase. Febs Letters. 436: 28-34. PMID 9771888 DOI: 10.1016/S0014-5793(98)01090-4  0.657
1998 Sengupta A, Kabat J, Novak M, Wu Q, Grundke-Iqbal I, Iqbal K. Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. Archives of Biochemistry and Biophysics. 357: 299-309. PMID 9735171 DOI: 10.1006/Abbi.1998.0813  0.641
1998 Iqbal K, Alonso AC, Gong CX, Khatoon S, Pei JJ, Wang JZ, Grundke-Iqbal I. Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles. Journal of Neural Transmission. Supplementum. 53: 169-80. PMID 9700655 DOI: 10.1007/978-3-7091-6467-9_15  0.67
1998 Ikura Y, Kudo T, Tanaka T, Tanii H, Grundke-Iqbal I, Iqbal K, Takeda M. Levels of tau phosphorylation at different sites in Alzheimer disease brain. Neuroreport. 9: 2375-9. PMID 9694231 DOI: 10.1097/00001756-199807130-00041  0.677
1998 Pei JJ, Grundke-Iqbal I, Iqbal K, Bogdanovic N, Winblad B, Cowburn RF. Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration. Brain Research. 797: 267-77. PMID 9666145 DOI: 10.1016/S0006-8993(98)00296-0  0.634
1998 Tanaka T, Zhong J, Iqbal K, Trenkner E, Grundke-Iqbal I. The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases. Febs Letters. 426: 248-54. PMID 9599018 DOI: 10.1016/S0014-5793(98)00346-9  0.646
1998 Pei JJ, Gong CX, Iqbal K, Grundke-Iqbal I, Wu QL, Winblad B, Cowburn RF. Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains. Journal of Neural Transmission (Vienna, Austria : 1996). 105: 69-83. PMID 9588762 DOI: 10.1007/S007020050039  0.647
1998 Iqbal K, Grundke-Iqbal I. Tau phosphatase activity as a therapeutic target for AD Drug News and Perspectives. 11: 10-14. DOI: 10.1358/dnp.1998.11.1.863668  0.475
1997 Iqbal K, Grundke-Iqbal I. Elevated levels of tau and ubiquitin in brain and cerebrospinal fluid in Alzheimer's disease. International Psychogeriatrics / Ipa. 9: 289-96; discussion 3. PMID 9447449 DOI: 10.1017/S1041610297005024  0.671
1997 Ruben GC, Ciardelli TL, Grundke-Iqbal I, Iqbal K. Alzheimer disease hyperphosphorylated tau aggregates hydrophobically. Synapse (New York, N.Y.). 27: 208-29. PMID 9329157 DOI: 10.1002/(Sici)1098-2396(199711)27:3<208::Aid-Syn7>3.0.Co;2-H  0.663
1997 Singh TJ, Grundke-Iqbal I, Wu WQ, Chauhan V, Novak M, Kontzekova E, Iqbal K. Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates. Molecular and Cellular Biochemistry. 168: 141-8. PMID 9062903 DOI: 10.1023/A:1006807105059  0.671
1997 Sengupta A, Wu Q, Grundke-Iqbal I, Iqbal K, Singh TJ. Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5. Molecular and Cellular Biochemistry. 167: 99-105. PMID 9059986 DOI: 10.1023/A:1006883924775  0.642
1997 Alonso AD, Grundke-Iqbal I, Barra HS, Iqbal K. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proceedings of the National Academy of Sciences of the United States of America. 94: 298-303. PMID 8990203 DOI: 10.1073/Pnas.94.1.298  0.656
1997 Pei JJ, Tanaka T, Tung YC, Braak E, Iqbal K, Grundke-Iqbal I. Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain. Journal of Neuropathology and Experimental Neurology. 56: 70-8. PMID 8990130 DOI: 10.1097/00005072-199701000-00007  0.688
1997 Wisniewski HM, Gong CX, Badmaiew E, Grundke-lqbal I, Iqbal K, Wegiel J. Tau- Pathology In Hippocamp Al Formation Of Aged Dogs And Rats Chronically Treated With Okadaic Acid Journal of Neuropathology and Experimental Neurology. 56: 593. DOI: 10.1097/00005072-199705000-00101  0.321
1996 Gong CX, Shaikh S, Grundke-Iqbal I, Iqbal K. Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics. Brain Research. 741: 95-102. PMID 9001710 DOI: 10.1016/S0006-8993(96)00904-3  0.663
1996 Wang JZ, Grundke-Iqbal I, Iqbal K. Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1. Brain Research. Molecular Brain Research. 38: 200-8. PMID 8793108 DOI: 10.1016/0169-328X(95)00316-K  0.66
1996 Singh TJ, Zaidi T, Grundke-Iqbal I, Iqbal K. Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain. Molecular and Cellular Biochemistry. 154: 143-51. PMID 8717428 DOI: 10.1007/Bf00226782  0.641
1996 Wang JZ, Grundke-Iqbal I, Iqbal K. Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease. Nature Medicine. 2: 871-5. PMID 8705855 DOI: 10.1038/Nm0896-871  0.705
1996 Singh TJ, Wang JZ, Novak M, Kontzekova E, Grundke-Iqbal I, Iqbal K. Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules. Febs Letters. 387: 145-8. PMID 8674537 DOI: 10.1016/0014-5793(96)00485-1  0.605
1996 Singh TJ, Grundke-Iqbal I, Iqbal K. Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases. Archives of Biochemistry and Biophysics. 328: 43-50. PMID 8638936 DOI: 10.1006/Abbi.1996.0140  0.668
1996 Tanaka T, Iqbal K, Trenkner E, Grundke-Iqbal I. 621 The regulation of phosphorylation of Tau in SYSY neuroblastoma cells Neurobiology of Aging. 17: S154-S155. DOI: 10.1016/S0197-4580(96)80623-3  0.621
1996 del C. Alonso A, Grundke-Iqbal I, Barra H, Iqbal K. 620 Interaction between Alzheimer disease abnormally phosphorylated Tau and microtubule associated proteins Neurobiology of Aging. 17: S154. DOI: 10.1016/S0197-4580(96)80622-1  0.536
1996 Iqbal K, del C. Alonso A, Gong C, Khatoon S, Pei J, Wang J, Zaidi T, Grundke-Iqbal I. 572 Role of abnormal phosphorylation and glycosylation of tau in the formation of tangles and neurofibrillary degeneration Neurobiology of Aging. 17: S142. DOI: 10.1016/S0197-4580(96)80574-4  0.513
1996 Ikura Y, Kudo T, Grundke-Iqbal I, Iqbal K, Takeda M, Nishimura T. 536 Tau in Alzheimer disease brain is phosphorylated to different degrees at different sites Neurobiology of Aging. 17: S133-S134. DOI: 10.1016/S0197-4580(96)80538-0  0.661
1996 Sengupta A, Wu Q, Grundke-Iqbal I, Iqbal K, Singh T. 535 Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5 Neurobiology of Aging. 17: S133. DOI: 10.1016/S0197-4580(96)80537-9  0.66
1996 Gong C, Wegiel J, Wisniewski H, Badmajew E, Tanaka T, Grundke-Iqbal I, Iqbal K. 534 Tau-pathology in brain of rats after chronic treatment with okadaic acid Neurobiology of Aging. 17: S133. DOI: 10.1016/S0197-4580(96)80536-7  0.379
1996 Haque N, Tanaka T, Iqbal K, Grundke-Iqbal I. 532 Differentiation of SYSY cells: Effect on phosphorylation and biological activity of tau Neurobiology of Aging. 17: S132-S133. DOI: 10.1016/S0197-4580(96)80534-3  0.604
1996 Ruben G, Ciardelli T, Grundke-Iqbal I, Iqbal K. 518 Secondary structure of Alzheimer disease abnormally hyperphosphorylated tau (AD P-Tau) before and after phosphate removal using hydroflouric acid: Correlation with high resolution TEM imaging Neurobiology of Aging. 17: S129. DOI: 10.1016/S0197-4580(96)80520-3  0.491
1996 Pei J, Tanaka T, Gong C, Braak E, Cowburn R, Winblad B, Iqbal K, Grundke-Iqbal I. 516 Expression of protein kinase GSK-3 and protein phosphatases PP-1, PP 2A, and PP-2B in the brain of patients with Alzheimer's disease Neurobiology of Aging. 17: S128-S129. DOI: 10.1016/S0197-4580(96)80518-5  0.61
1996 Khatoon S, Grundke-Iqbal I, Iqbal K. 515 Isolation of glycogen synthase kinase-3 (GSK-3) and cyclin-dependent kinase-S (cdk-S) from Alzheimer disease and control brains Neurobiology of Aging. 17: S128. DOI: 10.1016/S0197-4580(96)80517-3  0.449
1996 Kudo T, Takeda M, Miyamae Y, Morihara T, Kashiwagi Y, Tatebayashi Y, Nishimura T, Tanaka T, Iqbal K, Grundke-Iqbal I. 319 Alterations of presenilin I in fibroblasts from familial Alzheimer disease patients Neurobiology of Aging. 17: S80. DOI: 10.1016/S0197-4580(96)80321-6  0.55
1996 Grundke-Iqbal I, Tanaka T, Tung Y, Haque N, Iqbal K. 299 Abnormal hyperphosphorylation of tau: An early and most significant deleterious event in neurofibrillary degeneration Neurobiology of Aging. 17: S75. DOI: 10.1016/S0197-4580(96)80301-0  0.435
1996 Singh T, Grundke-Iqbal I, Iqbal K. 168 Differential phosphorylation of three-repeat human tau isoforms by several protein kinases Neurobiology of Aging. 17: S43. DOI: 10.1016/S0197-4580(96)80170-9  0.611
1996 Grundke-Iqbal I, Kudo T, Khatoon S, Wu Q, Iqbal K. 7 Tau and Ubiquitin as diagnostic markers of Alzheimer disease Neurobiology of Aging. 17: S2. DOI: 10.1016/S0197-4580(96)80009-1  0.496
1995 Wang JZ, Gong CX, Zaidi T, Grundke-Iqbal I, Iqbal K. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. The Journal of Biological Chemistry. 270: 4854-60. PMID 7876258 DOI: 10.1074/Jbc.270.9.4854  0.625
1995 Haque N, Denman RB, Merz G, Grundke-Iqbal I, Iqbal K. Phosphorylation and accumulation of tau without any concomitant increase in tubulin levels in Chinese hamster ovary cells stably transfected with human tau441. Febs Letters. 360: 132-6. PMID 7875317 DOI: 10.1016/0014-5793(95)00089-R  0.622
1995 Tanaka T, Iqbal K, Trenkner E, Liu DJ, Grundke-Iqbal I. Abnormally phosphorylated tau in SY5Y human neuroblastoma cells. Febs Letters. 360: 5-9. PMID 7875300 DOI: 10.1016/0014-5793(95)00061-D  0.679
1995 Khatoon S, Grundke-Iqbal I, Iqbal K. Guanosine triphosphate binding to beta-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau. Journal of Neurochemistry. 64: 777-87. PMID 7830071 DOI: 10.1046/j.1471-4159.1995.64020777.x  0.618
1995 Singh TJ, Zaidi T, Grundke-Iqbal I, Iqbal K. Modulation of GSK-3-catalyzed phosphorylation of microtubule-associated protein tau by non-proline-dependent protein kinases. Febs Letters. 358: 4-8. PMID 7821426 DOI: 10.1016/0014-5793(94)01383-C  0.61
1995 Singh TJ, Haque N, Grundke-Iqbal I, Iqbal K. Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3. Febs Letters. 358: 267-72. PMID 7531159 DOI: 10.1016/0014-5793(94)01445-7  0.682
1995 Alonso Adel C, Grundke-Iqbal I, Iqbal K. Bovine and human tau, highly homologous but less crossreactive: implications for Alzheimer disease. Brain Research. Molecular Brain Research. 31: 194-200. PMID 7476029 DOI: 10.1016/0169-328X(95)00051-S  0.635
1995 Iqbal K, Grundke-Iqbal I. Alzheimer abnormally phosphorylated tau is more hyperphosphorylated than the fetal tau and causes the disruption of microtubules Neurobiology of Aging. 16: 375-379. DOI: 10.1016/0197-4580(95)00033-B  0.682
1995 Iqbal K, Grundke-Iqbal I. Abnormal hyperphosphorylation of tau: Participation of β-amyloid/peptide out and proline-directed protein kinases (PDPKs) and non-PDPKs in Neurobiology of Aging. 16: 398. DOI: 10.1016/0197-4580(94)00161-S  0.595
1994 Kudo T, Iqbal K, Ravid R, Swaab DF, Grundke-Iqbal I. Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels. Brain Research. 639: 1-7. PMID 8180825 DOI: 10.1016/0006-8993(94)91757-4  0.609
1994 Gong CX, Grundke-Iqbal I, Damuni Z, Iqbal K. Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease. Febs Letters. 341: 94-8. PMID 8137929 DOI: 10.1016/0014-5793(94)80247-5  0.674
1994 Khatoon S, Grundke-Iqbal I, Iqbal K. Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. Febs Letters. 351: 80-4. PMID 8076698 DOI: 10.1016/0014-5793(94)00829-9  0.682
1994 Rehman A, Tung YC, Iqbal K, Grundke-Iqbal I. Rabbit IgG cross-reacts with Alzheimer neurofibrillary tangles. Acta Neuropathologica. 87: 443-9. PMID 8059596 DOI: 10.1007/Bf00294170  0.662
1994 Iqbal K, Zaidi T, Bancher C, Grundke-Iqbal I. Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation. Febs Letters. 349: 104-8. PMID 8045285 DOI: 10.1016/0014-5793(94)00650-4  0.694
1994 Singh TJ, Grundke-Iqbal I, McDonald B, Iqbal K. Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases. Molecular and Cellular Biochemistry. 131: 181-9. PMID 8035784 DOI: 10.1007/Bf00925955  0.602
1994 Kudo T, Iqbal K, Ravid R, Swaab DF, Grundke-Iqbal I. Ubiquitin in cerebrospinal fluid: a rapid competitive enzyme-linked immunoflow assay. Neuroreport. 5: 1522-4. PMID 7948853 DOI: 10.1097/00001756-199407000-00028  0.466
1994 Iqbal K, Alonso AC, Gong CX, Khatoon S, Singh TJ, Grundke-Iqbal I. Mechanism of neurofibrillary degeneration in Alzheimer's disease. Molecular Neurobiology. 9: 119-23. PMID 7888088 DOI: 10.1007/Bf02816111  0.682
1994 Pei JJ, Sersen E, Iqbal K, Grundke-Iqbal I. Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals. Brain Research. 655: 70-6. PMID 7812792 DOI: 10.1016/0006-8993(94)91598-9  0.636
1993 Ruben GC, Iqbal K, Wisniewski HM, Johnson JE, Grundke-Iqbal I. Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein tau: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid. Brain Research. 602: 164-79. PMID 7680597 DOI: 10.1016/0006-8993(92)91092-S  0.591
1993 Iqbal K, Braak H, Braak E, Grundke-Iqbal I. Silver labeling of Alzheimer neurofibrillary changes and brain β-amyloid Journal of Histotechnology. 16: 335-341. DOI: 10.1179/His.1993.16.4.335  0.558
1993 Iqbal K, Gong CX, Singh TJ, Grundke-Iqbal I. ABNORMALLY PHOSPHORYLATED TAU IN ALZHEIMER DISEASE BRAIN Journal of Neuropathology and Experimental Neurology. 52: 266. DOI: 10.1097/00005072-199305000-00023  0.686
1992 Frackowiak J, Wisniewski HM, Wegiel J, Merz GS, Iqbal K, Wang KC. Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathologica. 84: 225-33. PMID 1414275 DOI: 10.1007/Bf00227813  0.388
1992 Lin FH, Lin R, Wisniewski HM, Hwang YW, Grundke-Iqbal I, Healy-Louie G, Iqbal K. Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains. Biochemical and Biophysical Research Communications. 182: 238-46. PMID 1370613 DOI: 10.1016/S0006-291X(05)80136-6  0.557
1992 Swaab DF, Grundke-Iqbal I, Iqbal K, Kremer HP, Ravid R, van de Nes JA. Tau and ubiquitin in the human hypothalamus in aging and Alzheimer's disease. Brain Research. 590: 239-49. PMID 1330213 DOI: 10.1016/0006-8993(92)91101-J  0.656
1992 Swaab D, Grundke-Iqbal I, Iqbal K, Lucassen P, Raadsheer F, Ravid R, Van de Nes J. The human hypothalamus and Alzheimer symptoms Neurobiology of Aging. 13: S44. DOI: 10.1016/0197-4580(92)90299-D  0.511
1991 Wang GP, Khatoon S, Iqbal K, Grundke-Iqbal I. Brain ubiquitin is markedly elevated in Alzheimer disease. Brain Research. 566: 146-51. PMID 1814531 DOI: 10.1016/0006-8993(91)91692-T  0.646
1991 Iqbal K, Grundke-Iqbal I. Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease. Molecular Neurobiology. 5: 399-410. PMID 1726645 DOI: 10.1007/Bf02935561  0.699
1991 Iqbal K, Braak E, Braak H, Zaidi T, Grundke-Iqbal I. A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Neurobiology of Aging. 12: 357-61. PMID 1720514 DOI: 10.1016/0197-4580(91)90022-C  0.62
1991 Lake S, Winblad B, Iqbal K. Second international conference on Alzheimer's disease and related disorders, Toronto 1990: Review of current research Neurobiology of Aging. 12: 609-612. PMID 1685221 DOI: 10.1016/0197-4580(91)90094-Z  0.332
1991 Wang GP, Iqbal K, Bucht G, Winblad B, Wisniewski HM, Grundke-Iqbal I. Alzheimer's disease: paired helical filament immunoreactivity in cerebrospinal fluid. Acta Neuropathologica. 82: 6-12. PMID 1659107 DOI: 10.1007/Bf00310917  0.6
1990 Grundke-Iqbal I, Fleming J, Tung YC, Lassmann H, Iqbal K, Joshi JG. Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia. Acta Neuropathologica. 81: 105-10. PMID 2082650 DOI: 10.1007/Bf00334497  0.618
1989 Bancher C, Grundke-Iqbal I, Iqbal K, Kim KS, Wisniewski HM. Immunoreactivity of neuronal lipofuscin with monoclonal antibodies to the amyloid beta-protein. Neurobiology of Aging. 10: 125-32. PMID 2657463 DOI: 10.1016/0197-4580(89)90021-3  0.601
1989 Grundke-Iqbal I, Iqbal K, George L, Tung YC, Kim KS, Wisniewski HM. Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 86: 2853-7. PMID 2649895 DOI: 10.1073/Pnas.86.8.2853  0.63
1989 Iqbal K. First international conference on Alzheimer's disease and related disorders Neurobiology of Aging. 10: 211-215. PMID 2566938 DOI: 10.1016/0197-4580(89)90034-1  0.357
1989 Wisniewski HM, Iqbal K, Bancher C, Miller D, Currie J. Cytoskeletal protein pathology and the formation of beta-amyloid fibers in Alzheimer's disease. Neurobiology of Aging. 10: 409-12; discussion 4. PMID 2510038 DOI: 10.1016/0197-4580(89)90079-1  0.49
1989 Iqbal K, Grundke-Iqbal I, Smith AJ, George L, Tung YC, Zaidi T. Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 86: 5646-50. PMID 2501795 DOI: 10.1073/Pnas.86.14.5646  0.597
1989 Iqbal K, Smith AJ, Zaidi T, Grundke-Iqbal I. Microtubule-associated protein tau. Identification of a novel peptide from bovine brain. Febs Letters. 248: 87-91. PMID 2498127 DOI: 10.1016/0014-5793(89)80437-5  0.582
1989 Perry G, Mulvihill P, Fried VA, Smith HT, Grundke-Iqbal I, Iqbal K. Immunochemical properties of ubiquitin conjugates in the paired helical filaments of Alzheimer disease. Journal of Neurochemistry. 52: 1523-8. PMID 2468737 DOI: 10.1111/J.1471-4159.1989.Tb09203.X  0.554
1989 Bancher C, Lassmann H, Budka H, Jellinger K, Grundke-Iqbal I, Iqbal K, Wiche G, Seitelberger F, Wisniewski HM. An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination. Journal of Neuropathology and Experimental Neurology. 48: 81-93. PMID 2462024 DOI: 10.1097/00005072-198901000-00007  0.55
1989 Iqbal K, Grundke-Iqbal I, Smith. A. MICROTUBULE ASSOCIATED PROTEIN TAU Journal of Neuropathology and Experimental Neurology. 48: 353. DOI: 10.1097/00005072-198905000-00164  0.617
1989 Bancher C, Grundke-Iqbal I, Iqbal K, Kim KS, Wisniewski HM. A FRAGMENT OF THE AMYLOID PRECURSOR PROTEIN IN NEURONAL LIPOFUSCIN? Journal of Neuropathology and Experimental Neurology. 48: 332. DOI: 10.1097/00005072-198905000-00100  0.544
1989 Grundke-Iqbal I, Iqbal K. MICROTUBULE ASSOCIATED PROTEIN TAU Journal of Neuropathology and Experimental Neurology. 48: 331. DOI: 10.1097/00005072-198905000-00097  0.346
1988 Grundke-Iqbal I, Vorbrodt AW, Iqbal K, Tung YC, Wang GP, Wisniewski HM. Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments. Brain Research. 464: 43-52. PMID 3141008 DOI: 10.1016/0169-328X(88)90017-4  0.651
1988 Galloway PG, Grundke-Iqbal I, Iqbal K, Perry G. Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles. Journal of Neuropathology and Experimental Neurology. 47: 654-63. PMID 2459316 DOI: 10.1097/00005072-198811000-00008  0.638
1988 BANCHER C, NDKE-IQBAL IG, IQBAL K, KIM KS, WISNIEWSKI HM. IMMUNOREACTIVITY OF NEURONAL LIPOFUSCIN WITH MONOCLONAL ANTIBODIES TO THE AMYLOID BETA PROTEIN Alzheimer Disease & Associated Disorders. 2: 262. DOI: 10.1097/00002093-198802030-00111  0.319
1988 Alafuzoff I, Iqbal K, Friden H, Adolfsson R, Winblad B. Histopathological criteria for progressive dementia disorders. Clinical to pathological correlation Alzheimer Disease & Associated Disorders. 2: 222. DOI: 10.1097/00002093-198802030-00071  0.304
1988 BANCHER C, BRUNNER C, LASSMANN H, BUDKA H, JELLINGER K, SEITELBERGER F, GRUNDKE-IQBAL I, IQBAL K, WISNIEWSKI HM. TAU AND UBIQUITIN IMMUNOREACTIVITY AT DIFFERENT STAGES OF FORMATION OF ALZHEIMER NEUROFIBRILLARY TANGLES Alzheimer Disease & Associated Disorders. 2: 202. DOI: 10.1097/00002093-198802030-00051  0.637
1988 WANG GP, GRUNDKE-IQBAL I, IQBAL K. QUANTITATION OF MICROTOBULE ASSOCIATED PROTEIN TAU IN PAIRED HELICAL FILAMENTS BY IMMUNOASSAY Alzheimer Disease & Associated Disorders. 2: 201. DOI: 10.1097/00002093-198802030-00050  0.614
1988 RUBEN GC, GRUNDKE-IQBAL I, IQBAL K, WISNIEWSKI HM. MICROTUBULE ASSOCIATED PROTEIN TAU Alzheimer Disease & Associated Disorders. 2: 192. DOI: 10.1097/00002093-198802030-00041  0.454
1988 IQBAL K, WANG GP, WISNIEWSKI HH, GRUNDKE-IQBAL I. PAIRED HELICAL FILAMENT (PHF) IMMUNOREACTIVITY IN CSF Alzheimer Disease & Associated Disorders. 2: 175. DOI: 10.1097/00002093-198802030-00024  0.558
1987 Alafuzoff I, Iqbal K, Friden H, Adolfsson R, Winblad B. Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis. Acta Neuropathologica. 74: 209-25. PMID 3673513 DOI: 10.1007/Bf00688184  0.426
1987 Wisniewski HM, Iqbal K, Grundke-Iqbal I, Rubenstein R. The solubility controversy of paired helical filaments: a commentary. Neurochemical Research. 12: 93-5. PMID 3574590 DOI: 10.1007/Bf00971370  0.519
1987 Iqbal K, Grundke-Iqbal I, Merz PA, Wisniewski HM, Zaidi T. In vitro assembly and isolation of neurofilaments and microtubules from mammalian CNS. Brain Research. 388: 163-72. PMID 3113660 DOI: 10.1016/0169-328X(87)90010-6  0.533
1987 Bancher C, Lassmann H, Budka H, Grundke-Iqbal I, Iqbal K, Wiche G, Seitelberger F, Wisniewski HM. Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles. Acta Neuropathologica. 74: 39-46. PMID 2444063 DOI: 10.1007/Bf00688336  0.656
1987 Iqbal K, Grundke-Iqbal I, Wisniewski HM. Alzheimer's disease, microtubule and neurofilament proteins, and axoplasmic flow. Lancet. 1: 102. PMID 2432366 DOI: 10.1016/S0140-6736(87)91937-4  0.589
1987 Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM, Iqbal K. CLONING AND CHARACTERIZATION OF A cDNA ENCODING THE ALZHEIMERʼS DISEASE AND DOWNʼS SYNDROME AMYLOID PEPTIDE Journal of Neuropathology and Experimental Neurology. 46: 396. DOI: 10.1097/00005072-198705000-00200  0.315
1987 Grundke-Iqbal I, Iqbal K, Wang GP, Wisniewaki HM. MICROTUBULE ASSOCIATED PROTEIN TAU IN ALZHEIMER PAIRED HELICAL FILAMENTS (PHF) Journal of Neuropathology and Experimental Neurology. 46: 376. DOI: 10.1097/00005072-198705000-00141  0.66
1987 Merz PA, Wrzolek M, Kascsak RJ, Grundke-Iqbal I, Iqbal K, Binder L, Kosik K, Wisniewski HM. IMMUNE ELECTRON MICROSCOPY OF PAIRED HELICAL FILAMENTS (PHF) WITH TAU ANTIBODIES Journal of Neuropathology and Experimental Neurology. 46: 376. DOI: 10.1097/00005072-198705000-00139  0.544
1987 WRZOLEK M, MERZ PA, KASCSAK RJ, GRUNDKE-IQBAL I, IQBAL K, RUBENSTEIN R, WISNIEWSKI HM, Lossinsky A. IMMUNE ELECTRON MICROSCOPY OF MONOCLONAL ANTIBODIES TO ALZHEIMER NEUROFIBRILLARY TANGLES Journal of Neuropathology and Experimental Neurology. 46: 333. DOI: 10.1097/00005072-198705000-00012  0.534
1987 Iqbal K, Grundke-Iqbal I, Wisniewski HM. A SILVER IMPREGNATION METHOD SPECIFIC FOR ALZHEIMER PAIRED HELICAL FILAMENTS (PHF) STAINS MICROTUBULE ASSOCIATED PROTEIN TAU. Journal of Neuropathology and Experimental Neurology. 46: 333. DOI: 10.1097/00005072-198705000-00011  0.653
1987 Grundke-Iqbal I, Iqbal K, Tung Y, Quinlan M, Wisniewski H, Binder L. Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology Alzheimer Disease & Associated Disorders. 1: 202. DOI: 10.1097/00002093-198701030-00020  0.553
1987 Iqbal K, Zaidi T, Wen G, Grundke-Iqbal I, Merz P, Shaikh S, Wisniewski H, AlafuzofT I, Winblad B. Defective brain microtubule assembly in Alzheimer??s disease Alzheimer Disease & Associated Disorders. 1: 201-202. DOI: 10.1097/00002093-198701030-00017  0.45
1987 Rubenstein R, Kascsak R, Merz P, Wisniewski H, Carp R, Iqbal K. Paired helical filaments associated with Alzheimer??s disease are readily soluble structures Alzheimer Disease & Associated Disorders. 1: 201. DOI: 10.1097/00002093-198701030-00015  0.426
1986 Iqbal K, Grundke-Iqbal I, Zaidi T, Ali N, Wisniewski HM. Are Alzheimer neurofibrillary tangles insoluble polymers? Life Sciences. 38: 1695-700. PMID 3702598 DOI: 10.1016/0024-3205(86)90414-5  0.563
1986 Iqbal K, Grundke-Iqbal I, Wisniewski HM. Neuronal cytoskeleton in aging and dementia. Progress in Brain Research. 70: 279-88. PMID 3554352  0.443
1986 Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proceedings of the National Academy of Sciences of the United States of America. 83: 4913-7. PMID 3088567 DOI: 10.1073/Pnas.83.13.4913  0.652
1986 Rubenstein R, Kascsak RJ, Merz PA, Wisniewski HM, Carp RI, Iqbal K. Paired helical filaments associated with Alzheimer disease are readily soluble structures. Brain Research. 372: 80-8. PMID 2939924 DOI: 10.1016/0006-8993(86)91460-5  0.464
1986 Iqbal K, Grundke-Iqbal I, Zaidi T, Merz PA, Wen GY, Shaikh SS, Wisniewski HM, Alafuzoff I, Winblad B. Defective brain microtubule assembly in Alzheimer's disease. Lancet. 2: 421-6. PMID 2874414 DOI: 10.1016/S0140-6736(86)92134-3  0.669
1986 Braak H, Braak E, Grundke-Iqbal I, Iqbal K. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neuroscience Letters. 65: 351-5. PMID 2423928 DOI: 10.1016/0304-3940(86)90288-0  0.61
1986 Grundke-Iqbal I, Iqbal K, Wisniewski HM. MICROTUBLE ASSOCIATED PROTEIN, TAU IS ABNORMALLY PHOSPHORYLATED IN ALZHEIMER BRAIN Journal of Neuropathology and Experimental Neurology. 45: 379. DOI: 10.1097/00005072-198605000-00194  0.685
1986 Iqbal K, Grundke-Iqbal I, Wisniewski HM. MICROTUBULE ASSOCIATED PROTEIN, TAU IS A MAJOR CONSTITUENT OF ALZHEIMER PAIRED HELICAL FILAMENTS Journal of Neuropathology and Experimental Neurology. 45: 378. DOI: 10.1097/00005072-198605000-00193  0.658
1986 Merz PA, Grundke-Iqbal I, Iqbal K, Rubenstein R, Wisniewski, Rudelli RD. Immune Electron Microscopy Of Alzheimer Paired Helical Filaments (Phf) Journal of Neuropathology and Experimental Neurology. 45: 338. DOI: 10.1097/00005072-198605000-00076  0.541
1986 Wen GY, Wisniewski HM, Wang KC, Iqbal K, Rubenstein R. Coexistence Of Two Types Of Paired Helical Filaments In AlzheimerʼS Diseased Brains Journal of Neuropathology and Experimental Neurology. 45: 337. DOI: 10.1097/00005072-198605000-00072  0.378
1986 Wisniewski HM, Moretz RC, Iqbal K. No evidence for aluminum in etiology and pathogenesis of alzheimer's disease Neurobiology of Aging. 7: 532-535. DOI: 10.1016/0197-4580(86)90103-X  0.399
1986 Wisniewski HM, Rudelli RD, Iqbal K, Merz G. AD/SDAT, plaques, tangles and BBB changes Neurobiology of Aging. 7: 504. DOI: 10.1016/0197-4580(86)90088-6  0.409
1986 Iqbal K. Biology of Alzheimer's disease through biochemistry of tangles and plaques Neurobiology of Aging. 7: 434-437. DOI: 10.1016/0197-4580(86)90057-6  0.486
1985 Benuck M, Iqbal K, Wisniewski HM, Lajtha A. Proteolytic activity in brains of rabbits treated with aluminum. Neurochemical Research. 10: 729-36. PMID 2993936 DOI: 10.1007/Bf00964531  0.3
1985 Grundke-Iqbal I, Iqbal K, Tung YC, Wang GP, Wisniewski HM. Alzheimer paired helical filaments: cross-reacting polypeptide/s normally present in brain. Acta Neuropathologica. 66: 52-61. PMID 2581415 DOI: 10.1007/Bf00698295  0.626
1985 Grundke-Iqbal I, Wang GP, Iqbal K, Tung YC, Wisniewski HM. Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies. Acta Neuropathologica. 68: 279-83. PMID 2418620 DOI: 10.1007/Bf00690830  0.602
1984 Wang GP, Grundke-Iqbal I, Kascsak RJ, Iqbal K, Wisniewski HM. Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigen(s). Acta Neuropathologica. 62: 268-75. PMID 6730905 DOI: 10.1007/Bf00687608  0.555
1984 Wisniewski HM, Merz PA, Iqbal K. Ultrastructure of paired helical filaments of Alzheimer's neurofibrillary tangle. Journal of Neuropathology and Experimental Neurology. 43: 643-56. PMID 6542129 DOI: 10.1097/00005072-198411000-00008  0.477
1984 Iqbal K, Zaidi T, Thompson CH, Merz PA, Wisniewski HM. Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition. Acta Neuropathologica. 62: 167-77. PMID 6538056 DOI: 10.1007/Bf00691849  0.408
1984 Grundke-Iqbal I, Iqbal K, Tung YC, Wisniewski HM. Alzheimer paired helical filaments: immunochemical identification of polypeptides. Acta Neuropathologica. 62: 259-67. PMID 6428153 DOI: 10.1007/Bf00687607  0.586
1984 Iqbal K, Wisniewski HM, Garruto RM, Masters CL, Gajdusek DC. 166 GUAM PARKINSONISM DEMENTIA Journal of Neuropathology and Experimental Neurology. 43: 348. DOI: 10.1097/00005072-198405000-00172  0.347
1984 Grundke-Iqbal I, Iqbal K, Tung YC, Wang GP, Wisniewski HM. 163 ARE ALZHEIMER PAIRED HELICAL FILAMENT POLYPEPTIDES PRESENT NORMALLY IN BRAIN? Journal of Neuropathology and Experimental Neurology. 43: 347. DOI: 10.1097/00005072-198405000-00169  0.623
1984 Wang GP, Grundke-Iqbal I, Iqbal K, Wisniewski HM. 159 IDENTIFICATION OF ALZHEIMER PAIRED HELICAL FILAMENT POLYPEPTIDES WITH MONOCLONAL ANTIBODIES Journal of Neuropathology and Experimental Neurology. 43: 346. DOI: 10.1097/00005072-198405000-00165  0.568
1983 Merz PA, Wisniewski HM, Somerville RA, Bobin SA, Masters CL, Iqbal K. Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques. Acta Neuropathologica. 60: 113-24. PMID 6683919 DOI: 10.1007/Bf00685355  0.398
1983 Iqbal K, Grundke-Iqbal I, Wisniewski HM. 110 SOLUBILITY AND PROTEIN COMPOSITION OF ALZHEIMER NEUROFIBRILLARY TANGLES Journal of Neuropathology and Experimental Neurology. 42: 341. DOI: 10.1097/00005072-198305000-00117  0.609
1983 Grundke-Iqbal I, Wang GP, Iqbal K, Kascsak R, Wisniewski HM. 109 RELATIONSHIP OF ALZHEIMER PAIRED HELICAL FILAMENTS WITH MICROTUBULES AND NEUROFILAMENTS Journal of Neuropathology and Experimental Neurology. 42: 341. DOI: 10.1097/00005072-198305000-00116  0.616
1982 Iqbal K, Grundke-Iqbal I, Merz PA, Wisniewski HM. Alzheimer Neurofibrillary tangle: morphology and biochemistry. Experimental Brain Research. 10-4. PMID 7151901  0.608
1982 Grundke-Iqbal I, Iqbal K, Wisniewski HM. Immunocytochemical studies on neurofibrillary changes. Experimental Brain Research. 20-5. PMID 6185357  0.413
1982 Iqbal K, Merz PA, Wisniewski HM. IN VITRO ASSEMBLY OF MICROTUBULES AND NEUROFILAMENTS FROM ALZHEIMER BRAIN Journal of Neuropathology and Experimental Neurology. 41: 364. DOI: 10.1097/00005072-198205000-00079  0.456
1981 Dziedzic JD, Wisniewski HM, Iqbal K. Monoamine oxidase activity in normal and Alzheimer brains. Annals of Neurology. 9: 618-9. PMID 7259128 DOI: 10.1002/Ana.410090621  0.422
1981 Merz PA, Somerville RA, Wisniewski HM, Iqbal K. Abnormal fibrils from scrapie-infected brain. Acta Neuropathologica. 54: 63-74. PMID 7195134 DOI: 10.1007/Bf00691333  0.372
1981 Iqbal K, Merz V, Grundke-Iqbal I, Wisnlewski HM. 49 STUDIES ON MAMMALIAN NEUROFILAMENTS ISOLATED BY IN VITRO ASSEMBLY-DISASSEMBLY Journal of Neuropathology and Experimental Neurology. 40: 315. DOI: 10.1097/00005072-198105000-00056  0.473
1981 Grundke-Iqbal I, Iqbal K, Merz P, Wisniewski HM. 40 ISOLATION AND PROPERTIES OF ALZHEIMER NEUROFIBRILLARY TANGLES Journal of Neuropathology and Experimental Neurology. 40: 312. DOI: 10.1097/00005072-198105000-00047  0.586
1980 Hetnarski B, Wisniewski HM, Iqbal K, Dziedzic JD, Lajtha A. Central cholinergic activity in aluminum-induced neurofibrillary degeneration. Annals of Neurology. 7: 489-90. PMID 7396428 DOI: 10.1002/Ana.410070517  0.33
1980 Iqbal K, Johnson AB, Grundke-Iqbal I, Wisniewski HM. 79 STUDIES ON ALZHEIMER NEUROFIBRILLARY TANGLE CROSS-REACTING ANTIGEN/S Journal of Neuropathology and Experimental Neurology. 39: 363. DOI: 10.1097/00005072-198005000-00087  0.575
1980 Dziedzic JD, Iqbal K, Wisniewski HM. CENTRAL CHOLINERGIC ACTIVITY IN ALZHEIMER DEMENTIA Journal of Neuropathology and Experimental Neurology. 39: 351. DOI: 10.1097/00005072-198005000-00051  0.42
1979 Grundke-Iqbal I, Johnson AB, Terry RD, Wisniewski HM, Iqbal K. Alzheimer neurofibrillary tangles: antiserum and immunohistological staining. Annals of Neurology. 6: 532-7. PMID 394670 DOI: 10.1002/Ana.410060612  0.722
1979 Wisniewski HM, Bobin S, Mehta P, Iqbal K. ISOLATION AND CHARACTERIZATION OF VESSELS AND AMYLOID STARS FROM CEREBRUM OF PATIENTS WITH SENILE DEMENTIA OF ALZHEIMER TYPE Journal of Neuropathology and Experimental Neurology. 38: 349. DOI: 10.1097/00005072-197905000-00153  0.395
1979 Iqbal K, Grundke-Iqbal I, Johnson AB, Wisniewski HM. ARE NEUROTUBULE PROTEINS INVOLVED IN THE FORMATION OF ALZHEIMER NEUROFIBRILLARY TANGLES? Journal of Neuropathology and Experimental Neurology. 38: 322. DOI: 10.1097/00005072-197905000-00074  0.635
1978 Iqbal K, Grundke-Iqbal I, Wisniewski HM, Terry RD. Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules. Brain Research. 142: 321-32. PMID 630387 DOI: 10.1016/0006-8993(78)90638-8  0.681
1977 Iqbal K, Grundke-Iqbal I, Wisniewski HM, Terry RD. On neurofilament and neurotubule proteins from human autopsy tissue. Journal of Neurochemistry. 29: 417-24. PMID 894298 DOI: 10.1111/J.1471-4159.1977.Tb10689.X  0.6
1977 Iqbal K, Grundke-Iqbal I, Wisniewski HM. Oligodendroglia from human autopsied brain: bulk isolation and some chemical properties. Journal of Neurochemistry. 28: 707-16. PMID 894279 DOI: 10.1111/J.1471-4159.1977.Tb10617.X  0.415
1975 Iqbal K, Wisniewski HM, Grundke-Iqbal I, Korthals JK, Terry RD. Chemical pathology of neurofibrils. Neurofibrillary tangles of Alzheimer's presenile-senile dementia. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 23: 563-9. PMID 1141687 DOI: 10.1177/23.7.1141687  0.693
1974 Iqbal K, Wi?niewski HM, Shelanski ML, Brostoff S, Liwnicz BH, Terry RD. Protein changes in senile dementia. Brain Research. 77: 337-43. PMID 4604978 DOI: 10.1016/0006-8993(74)90798-7  0.661
1974 Iqbal K, Tellez-Nagel I, Grundke-Iqbal I. Protein abnormalities in Huntington's chorea. Brain Research. 76: 178-84. PMID 4276706 DOI: 10.1016/0006-8993(74)90527-7  0.458
Low-probability matches (unlikely to be authored by this person)
2005 Ruben GC, Novak M, Edwards PC, Iqbal K. Alzheimer paired helical filaments (PHFs) studied by high-resolution TEM: what can vertical Pt-C replication tell us about the organization of the pronase-digested PHF core? Microscopy Research and Technique. 67: 196-209. PMID 16103996 DOI: 10.1002/Jemt.20198  0.298
1987 Iqbal K, Grundke-Iqbal I, Wisniewski H. Alzheimer??s disease, microtubule and neurofilament proteins, and axoplasmic flow Alzheimer Disease & Associated Disorders. 1: 202. DOI: 10.1097/00002093-198701030-00019  0.298
2006 Iqbal K, Kazim SF. P3-055: RESCUE OF NEUROTROPHIC DEFICIT DURING PRENATAL TO EARLY POSTNATAL DEVELOPMENT CAN PREVENT ALZHEIMER-LIKE COGNITIVE IMPAIRMENT LATER IN LIFE Alzheimer's & Dementia. 14: P1085-P1085. DOI: 10.1016/J.Jalz.2018.06.1411  0.295
2015 Shi J, Gu JH, Dai CL, Gu J, Jin X, Sun J, Iqbal K, Liu F, Gong CX. O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling. Scientific Reports. 5: 14500. PMID 26412745 DOI: 10.1038/Srep14500  0.294
1990 Miller DL, Potempska A, Papayannopoulos IA, Iqbal K, Styles J, Kim KS, Mehta PR, Currie JR. Characterization Of The Cerebral Amyloid Peptides And Their Precursors: 18 Journal of Neuropathology and Experimental Neurology. 49: 267. DOI: 10.1097/00005072-199005000-00024  0.293
1988 MILLER DL, CURRIE JR, IQBAL K, POTEMPSKA A. RELATIONSHIPS AMONG THE CEREBRAL AMYLOID PEPTIDES AND THEIR PRECURSORS Alzheimer Disease & Associated Disorders. 2: 253. DOI: 10.1097/00002093-198802030-00102  0.29
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