Wendy J. Lynch - Publications

Affiliations: 
University of Virginia, Charlottesville, VA 
Area:
Drug addiction, sex differences

80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Towers EB, Shapiro DA, Abel JM, Bakhti-Suroosh A, Kupkova K, Auble DT, Grant PA, Lynch WJ. Transcriptional Profile of Exercise-Induced Protection Against Relapse to Cocaine Seeking in a Rat Model. Biological Psychiatry Global Open Science. 3: 734-745. PMID 37881559 DOI: 10.1016/j.bpsgos.2023.01.007  0.447
2023 Towers EB, Williams IL, Qillawala EI, Lynch WJ. Role of nucleus accumbens dopamine 2 receptors in motivating cocaine use in male and female rats prior to and following the development of an addiction-like phenotype. Frontiers in Pharmacology. 14: 1237990. PMID 37564182 DOI: 10.3389/fphar.2023.1237990  0.507
2023 Le AL, Lynch WJ, Rissman E. Sex chromosome complement and estradiol modify cocaine self-administration behaviors in male mice. Neuroendocrinology. PMID 37348474 DOI: 10.1159/000531648  0.481
2023 Towers EB, Kilgore M, Bakhti-Suroosh A, Pidaparthi L, Williams IL, Abel JM, Lynch WJ. Sex differences in the neuroadaptations associated with incubated cocaine-craving: A focus on the dorsomedial prefrontal cortex. Frontiers in Behavioral Neuroscience. 16: 1027310. PMID 36688133 DOI: 10.3389/fnbeh.2022.1027310  0.83
2022 Lynch WJ, Bakhti-Suroosh A, Abel JM. Impact of high-access exercise prior to and during early adolescence on later vulnerability to opioid use and relapse in male rats. Translational Psychiatry. 12: 425. PMID 36192388 DOI: 10.1038/s41398-022-02180-w  0.79
2022 Towers EB, Setaro B, Lynch WJ. Sex- and Dose-Dependent Differences in the Development of an Addiction-Like Phenotype Following Extended-Access Fentanyl Self-Administration. Frontiers in Pharmacology. 13: 841873. PMID 35370634 DOI: 10.3389/fphar.2022.841873  0.344
2021 Towers EB, Bakhti-Suroosh A, Lynch WJ. Females develop features of an addiction-like phenotype sooner during withdrawal than males. Psychopharmacology. PMID 33907871 DOI: 10.1007/s00213-021-05846-3  0.803
2021 Bakhti-Suroosh A, Towers EB, Lynch WJ. A buprenorphine-validated rat model of opioid use disorder optimized to study sex differences in vulnerability to relapse. Psychopharmacology. PMID 33404740 DOI: 10.1007/s00213-020-05750-2  0.761
2020 Lynch WJ, Bakhti-Suroosh A, Abel JM, Davis C. Shifts in the neurobiological mechanisms motivating cocaine use with the development of an addiction-like phenotype in male rats. Psychopharmacology. PMID 33241478 DOI: 10.1007/s00213-020-05732-4  0.82
2020 Harp SJ, Martini M, Lynch WJ, Rissman EF. Sexual Differentiation and Substance Use: A Mini Review. Endocrinology. PMID 32761086 DOI: 10.1210/endocr/bqaa129  0.383
2020 Martini M, Irvin JW, Lee CG, Lynch WJ, Rissman EF. Sex chromosome complement influences vulnerability to cocaine in mice. Hormones and Behavior. 104821. PMID 32721403 DOI: 10.1016/j.yhbeh.2020.104821  0.518
2019 Bakhti-Suroosh A, Nesil T, Lynch WJ. Tamoxifen Blocks the Development of Motivational Features of an Addiction-Like Phenotype in Female Rats. Frontiers in Behavioral Neuroscience. 13: 253. PMID 31780909 DOI: 10.3389/fnbeh.2019.00253  0.83
2019 Abel JM, Nesil T, Bakhti-Suroosh A, Grant PA, Lynch WJ. Mechanisms underlying the efficacy of exercise as an intervention for cocaine relapse: a focus on mGlu5 in the dorsal medial prefrontal cortex. Psychopharmacology. PMID 31161451 DOI: 10.1007/s00213-019-05208-0  0.789
2019 Sanchez V, Bakhti-Suroosh A, Chen A, Brunzell DH, Erisir A, Lynch WJ. Exercise during Abstinence Normalizes Ultrastructural Synaptic Plasticity Associated with Nicotine-Seeking following Extended Access Self-Administration. The European Journal of Neuroscience. PMID 30888721 DOI: 10.1111/Ejn.14408  0.79
2018 Nesil T, Narmeen S, Bakhti-Suroosh A, Lynch WJ. Effect of menthol on nicotine intake and relapse vulnerability in a rat model of concurrent intravenous menthol/nicotine self-administration. Psychopharmacology. PMID 30483833 DOI: 10.1007/s00213-018-5128-9  0.765
2018 Wang TR, Moosa S, Dallapiazza RF, Elias WJ, Lynch WJ. Deep brain stimulation for the treatment of drug addiction. Neurosurgical Focus. 45: E11. PMID 30064320 DOI: 10.3171/2018.5.FOCUS18163  0.368
2018 Smith MA, Fronk GE, Abel JM, Lacy RT, Bills SE, Lynch WJ. Resistance exercise decreases heroin self-administration and alters gene expression in the nucleus accumbens of heroin-exposed rats. Psychopharmacology. PMID 29396617 DOI: 10.1007/S00213-018-4840-9  0.529
2017 Lynch WJ, Robinson AM, Abel J, Smith MA. Exercise as a Prevention for Substance Use Disorder: A Review of Sex Differences and Neurobiological Mechanisms. Current Addiction Reports. 4: 455-466. PMID 29430384 DOI: 10.1007/S40429-017-0178-3  0.462
2017 Lynch WJ, Abel J, Robinson AM, Smith MA. Exercise as a Sex-Specific Treatment for Substance Use Disorder. Current Addiction Reports. 4: 467-481. PMID 29404264 DOI: 10.1007/S40429-017-0177-4  0.479
2017 Lynch WJ, Tan L, Narmeen S, Beiter R, Brunzell DH. Exercise or saccharin during abstinence block estrus-induced increases in nicotine-seeking. Physiology & Behavior. PMID 29080668 DOI: 10.1016/j.physbeh.2017.10.026  0.44
2017 Lynch WJ. Modeling the development of drug addiction in male and female animals. Pharmacology, Biochemistry, and Behavior. PMID 28624586 DOI: 10.1016/j.pbb.2017.06.006  0.416
2017 Lynch WJ, Beiter RM, Peterson AB, Abel J. Exercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model Drug and Alcohol Dependence. 171: e124. DOI: 10.1016/j.drugalcdep.2016.08.345  0.367
2016 Carroll ME, Lynch WJ. How to study sex differences in addiction using animal models. Addiction Biology. PMID 27345022 DOI: 10.1111/adb.12400  0.405
2016 Strickland JC, Abel JM, Lacy RT, Beckmann JS, Witte MA, Lynch WJ, Smith MA. The effects of resistance exercise on cocaine self-administration, muscle hypertrophy, and BDNF expression in the nucleus accumbens. Drug and Alcohol Dependence. PMID 27137405 DOI: 10.1016/J.Drugalcdep.2016.04.019  0.549
2016 Beiter RM, Peterson AB, Abel J, Lynch WJ. Exercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model. Translational Psychiatry. 6: e792. PMID 27115123 DOI: 10.1038/tp.2016.58  0.535
2015 Sanchez V, Lycas MD, Lynch WJ, Brunzell DH. Wheel running exercise attenuates vulnerability to self-administer nicotine in rats. Drug and Alcohol Dependence. 156: 193-8. PMID 26433561 DOI: 10.1016/J.Drugalcdep.2015.09.022  0.761
2015 Moore CF, Lynch WJ. Alcohol preferring (P) rats as a model for examining sex differences in alcohol use disorder and its treatment. Pharmacology, Biochemistry, and Behavior. 132: 1-9. PMID 25712173 DOI: 10.1016/J.Pbb.2015.02.014  0.544
2015 Doyle SE, Feng H, Garber G, Menaker M, Lynch WJ. Effects of circadian disruption on methamphetamine consumption in methamphetamine-exposed rats. Psychopharmacology. 232: 2169-79. PMID 25543849 DOI: 10.1007/s00213-014-3845-2  0.364
2014 Doyle SE, Ramôa C, Garber G, Newman J, Toor Z, Lynch WJ. A shift in the role of glutamatergic signaling in the nucleus accumbens core with the development of an addicted phenotype. Biological Psychiatry. 76: 810-5. PMID 24629536 DOI: 10.1016/J.Biopsych.2014.02.005  0.809
2014 Moore CF, Lycas MD, Bond CW, Johnson BA, Lynch WJ. Acute and chronic administration of a low-dose combination of topiramate and ondansetron reduces ethanol's reinforcing effects in male alcohol preferring (P) rats. Experimental and Clinical Psychopharmacology. 22: 35-42. PMID 24490709 DOI: 10.1037/A0035215  0.773
2014 Peterson AB, Hivick DP, Lynch WJ. Dose-dependent effectiveness of wheel running to attenuate cocaine-seeking: impact of sex and estrous cycle in rats. Psychopharmacology. 231: 2661-70. PMID 24464528 DOI: 10.1007/s00213-014-3437-1  0.504
2014 Sanchez V, Moore CF, Brunzell DH, Lynch WJ. Sex differences in the effect of wheel running on subsequent nicotine-seeking in a rat adolescent-onset self-administration model. Psychopharmacology. 231: 1753-62. PMID 24271035 DOI: 10.1007/S00213-013-3359-3  0.611
2014 Moore CF, Protzuk OA, Johnson BA, Lynch WJ. The efficacy of a low dose combination of topiramate and naltrexone on ethanol reinforcement and consumption in rat models. Pharmacology, Biochemistry, and Behavior. 116: 107-15. PMID 24252444 DOI: 10.1016/J.Pbb.2013.11.013  0.572
2014 Ramôa CP, Doyle SE, Lycas MD, Chernau AK, Lynch WJ. Diminished role of dopamine D1-receptor signaling with the development of an addicted phenotype in rats. Biological Psychiatry. 76: 8-14. PMID 24199666 DOI: 10.1016/J.Biopsych.2013.09.028  0.791
2014 Peterson AB, Abel JM, Lynch WJ. Dose-dependent effects of wheel running on cocaine-seeking and prefrontal cortex Bdnf exon IV expression in rats. Psychopharmacology. 231: 1305-14. PMID 24173624 DOI: 10.1007/s00213-013-3321-4  0.484
2014 Peterson AB, Abel J, Lynch W. Wheel running dose dependently attenuates cocaine-seeking and associated neuroadaptations in the prefrontal cortex Drug and Alcohol Dependence. 140: e175-e176. DOI: 10.1016/J.DRUGALCDEP.2014.02.493  0.473
2013 Lynch WJ, Peterson AB, Sanchez V, Abel J, Smith MA. Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis. Neuroscience and Biobehavioral Reviews. 37: 1622-44. PMID 23806439 DOI: 10.1016/J.Neubiorev.2013.06.011  0.504
2013 Ramôa CP, Doyle SE, Naim DW, Lynch WJ. Estradiol as a mechanism for sex differences in the development of an addicted phenotype following extended access cocaine self-administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1698-705. PMID 23481437 DOI: 10.1038/Npp.2013.68  0.832
2013 Sanchez V, Moore CF, Brunzell DH, Lynch WJ. Effect of wheel-running during abstinence on subsequent nicotine-seeking in rats. Psychopharmacology. 227: 403-11. PMID 23371488 DOI: 10.1007/S00213-012-2964-X  0.638
2012 Doyle SE, Breslin FJ, Rieger JM, Beauglehole A, Lynch WJ. Time and sex-dependent effects of an adenosine A2A/A1 receptor antagonist on motivation to self-administer cocaine in rats. Pharmacology, Biochemistry, and Behavior. 102: 257-63. PMID 22579716 DOI: 10.1016/j.pbb.2012.05.001  0.563
2011 Smith MA, Lynch WJ. Exercise as a potential treatment for drug abuse: evidence from preclinical studies. Frontiers in Psychiatry. 2: 82. PMID 22347866 DOI: 10.3389/Fpsyt.2011.00082  0.505
2011 Lynch WJ, Bond C, Breslin FJ, Johnson BA. Severity of drinking as a predictor of efficacy of the combination of ondansetron and topiramate in rat models of ethanol consumption and relapse. Psychopharmacology. 217: 3-12. PMID 21424693 DOI: 10.1007/S00213-011-2253-0  0.339
2010 Lynch WJ, Sofuoglu M. Role of progesterone in nicotine addiction: evidence from initiation to relapse. Experimental and Clinical Psychopharmacology. 18: 451-61. PMID 21186920 DOI: 10.1037/a0021265  0.399
2010 Lynch WJ, Piehl KB, Acosta G, Peterson AB, Hemby SE. Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex. Biological Psychiatry. 68: 774-7. PMID 20692647 DOI: 10.1016/j.biopsych.2010.06.022  0.572
2010 Abdolahi A, Acosta G, Breslin FJ, Hemby SE, Lynch WJ. Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortex. The European Journal of Neuroscience. 31: 733-41. PMID 20384816 DOI: 10.1111/j.1460-9568.2010.07114.x  0.454
2010 Angarita GA, Pittman B, Gueorguieva R, Kalayasiri R, Lynch WJ, Sughondhabirom A, Morgan PT, Malison RT. Regulation of cocaine self-administration in humans: lack of evidence for loading and maintenance phases. Pharmacology, Biochemistry, and Behavior. 95: 51-5. PMID 20005893 DOI: 10.1016/j.pbb.2009.12.005  0.51
2010 Breslin FJ, Johnson BA, Lynch WJ. Effect of topiramate treatment on ethanol consumption in rats. Psychopharmacology. 207: 529-34. PMID 19823810 DOI: 10.1007/S00213-009-1683-4  0.313
2009 Lynch WJ. Sex and ovarian hormones influence vulnerability and motivation for nicotine during adolescence in rats. Pharmacology, Biochemistry, and Behavior. 94: 43-50. PMID 19619575 DOI: 10.1016/j.pbb.2009.07.004  0.389
2008 Lynch WJ, Kalayasiri R, Sughondhabirom A, Pittman B, Coric V, Morgan PT, Malison RT. Subjective responses and cardiovascular effects of self-administered cocaine in cocaine-abusing men and women. Addiction Biology. 13: 403-10. PMID 18782384 DOI: 10.1111/j.1369-1600.2008.00115.x  0.499
2008 Lynch WJ, Girgenti MJ, Breslin FJ, Newton SS, Taylor JR. Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes. Brain Research. 1213: 166-77. PMID 18452895 DOI: 10.1016/j.brainres.2008.02.106  0.647
2008 Lynch WJ. Acquisition and maintenance of cocaine self-administration in adolescent rats: effects of sex and gonadal hormones. Psychopharmacology. 197: 237-46. PMID 18066534 DOI: 10.1007/s00213-007-1028-0  0.556
2007 Taylor JR, Lynch WJ, Sanchez H, Olausson P, Nestler EJ, Bibb JA. Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. 104: 4147-52. PMID 17360491 DOI: 10.1073/pnas.0610288104  0.689
2007 Lynch WJ, Kiraly DD, Caldarone BJ, Picciotto MR, Taylor JR. Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats. Psychopharmacology. 191: 263-71. PMID 17180335 DOI: 10.1007/s00213-006-0656-0  0.704
2007 Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Lappalainen J, Gelernter J, Cubells JF, Malison RT. Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration. Biological Psychiatry. 61: 1310-3. PMID 17157269 DOI: 10.1016/j.biopsych.2006.08.012  0.489
2006 Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Morgan PT, Cubells JF, Malison RT. Self-reported paranoia during laboratory "binge" cocaine self-administration in humans. Pharmacology, Biochemistry, and Behavior. 83: 249-56. PMID 16549106 DOI: 10.1016/j.pbb.2006.02.005  0.497
2006 Lynch WJ, Sughondhabirom A, Pittman B, Gueorguieva R, Kalayasiri R, Joshua D, Morgan P, Coric V, Malison RT. A paradigm to investigate the regulation of cocaine self-administration in human cocaine users: a randomized trial. Psychopharmacology. 185: 306-14. PMID 16521032 DOI: 10.1007/s00213-006-0323-5  0.52
2006 Lynch WJ. Sex differences in vulnerability to drug self-administration. Experimental and Clinical Psychopharmacology. 14: 34-41. PMID 16503703 DOI: 10.1037/1064-1297.14.1.34  0.451
2005 Lynch WJ, Taylor JR. Persistent changes in motivation to self-administer cocaine following modulation of cyclic AMP-dependent protein kinase A (PKA) activity in the nucleus accumbens. The European Journal of Neuroscience. 22: 1214-20. PMID 16176364 DOI: 10.1111/j.1460-9568.2005.04305.x  0.684
2005 Sughondhabirom A, Jain D, Gueorguieva R, Coric V, Berman R, Lynch WJ, Self D, Jatlow P, Malison RT. A paradigm to investigate the self-regulation of cocaine administration in humans. Psychopharmacology. 180: 436-46. PMID 15726333 DOI: 10.1007/s00213-005-2192-8  0.544
2005 Lynch WJ, Taylor JR. Decreased motivation following cocaine self-administration under extended access conditions: effects of sex and ovarian hormones. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 927-35. PMID 15647749 DOI: 10.1038/sj.npp.1300656  0.71
2005 Lynch WJ, Mangini LD, Taylor JR. Neonatal isolation stress potentiates cocaine seeking behavior in adult male and female rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 322-9. PMID 15508022 DOI: 10.1038/sj.npp.1300594  0.683
2005 Hart CL, Lynch WJ. Developing pharmacotherapies for cannabis and cocaine use disorders Current Neuropharmacology. 3: 95-114. DOI: 10.2174/1570159053586726  0.403
2004 Carroll ME, Lynch WJ, Roth ME, Morgan AD, Cosgrove KP. Sex and estrogen influence drug abuse. Trends in Pharmacological Sciences. 25: 273-9. PMID 15120494 DOI: 10.1016/J.Tips.2004.03.011  0.59
2004 Lynch WJ, Taylor JR. Sex differences in the behavioral effects of 24-h/day access to cocaine under a discrete trial procedure. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 943-51. PMID 14872204 DOI: 10.1038/sj.npp.1300389  0.705
2004 Lynch WJ, Roberts DC. Effects of cocaine self-administration on food-reinforced responding using a discrete trial procedure in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 669-75. PMID 14694351 DOI: 10.1038/sj.npp.1300363  0.63
2002 Freeman WM, Brebner K, Patel KM, Lynch WJ, Roberts DC, Vrana KE. Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression. Neurochemical Research. 27: 1181-92. PMID 12462416 DOI: 10.1023/A:1020929526688  0.804
2002 Lynch WJ, Roth ME, Carroll ME. Biological basis of sex differences in drug abuse: preclinical and clinical studies. Psychopharmacology. 164: 121-37. PMID 12404074 DOI: 10.1007/S00213-002-1183-2  0.404
2002 Morgan D, Brebner K, Lynch WJ, Roberts DC. Increases in the reinforcing efficacy of cocaine after particular histories of reinforcement. Behavioural Pharmacology. 13: 389-96. PMID 12394415 DOI: 10.1097/00008877-200209000-00012  0.808
2002 Roberts DC, Brebner K, Vincler M, Lynch WJ. Patterns of cocaine self-administration in rats produced by various access conditions under a discrete trials procedure. Drug and Alcohol Dependence. 67: 291-9. PMID 12127200 DOI: 10.1016/S0376-8716(02)00083-2  0.81
2002 Freeman WM, Brebner K, Lynch WJ, Patel KM, Robertson DJ, Roberts DC, Vrana KE. Changes in rat frontal cortex gene expression following chronic cocaine. Brain Research. Molecular Brain Research. 104: 11-20. PMID 12117546 DOI: 10.1016/S0169-328X(02)00197-3  0.799
2002 Carroll ME, Morgan AD, Lynch WJ, Campbell UC, Dess NK. Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences. Psychopharmacology. 161: 304-13. PMID 12021834 DOI: 10.1007/S00213-002-1030-5  0.557
2001 Freeman WM, Brebner K, Lynch WJ, Robertson DJ, Roberts DC, Vrana KE. Cocaine-responsive gene expression changes in rat hippocampus. Neuroscience. 108: 371-80. PMID 11738252 DOI: 10.1016/S0306-4522(01)00432-8  0.798
2001 Lynch WJ, Roth ME, Mickelberg JL, Carroll ME. Role of estrogen in the acquisition of intravenously self-administered cocaine in female rats. Pharmacology, Biochemistry, and Behavior. 68: 641-6. PMID 11526960 DOI: 10.1016/S0091-3057(01)00455-5  0.435
2000 Lynch WJ, Arizzi MN, Carroll ME. Effects of sex and the estrous cycle on regulation of intravenously self-administered cocaine in rats. Psychopharmacology. 152: 132-9. PMID 11057516 DOI: 10.1007/s002130000488  0.467
2000 Lynch WJ, Carroll ME. Reinstatement of cocaine self-administration in rats: sex differences. Psychopharmacology. 148: 196-200. PMID 10663435  0.479
1999 Lynch WJ, Carroll ME. Regulation of intravenously self-administered nicotine in rats. Experimental and Clinical Psychopharmacology. 7: 198-207. PMID 10472507 DOI: 10.1037/1064-1297.7.3.198  0.521
1999 Lynch WJ, Carroll ME. Sex differences in the acquisition of intravenously self-administered cocaine and heroin in rats. Psychopharmacology. 144: 77-82. PMID 10379627 DOI: 10.1007/s002130050979  0.495
1998 LaBounty LP, Lynch WJ, Carroll ME. Ethanol consumption in rats when dose size is under subject control. Experimental and Clinical Psychopharmacology. 6: 347-52. PMID 9861548 DOI: 10.1037/1064-1297.6.4.347  0.308
1998 Lynch WJ, Heaser WA, Carroll ME. Effects of amphetamine, butorphanol, and morphine pretreatment on the maintenance and reinstatement of cocaine-reinforced responding. Experimental and Clinical Psychopharmacology. 6: 255-63. PMID 9725109 DOI: 10.1037//1064-1297.6.3.255  0.456
1998 Lynch WJ, LaBounty LP, Carroll ME. A novel paradigm to investigate regulation of drug intake in rats self-administering cocaine or heroin intravenously. Experimental and Clinical Psychopharmacology. 6: 22-31. PMID 9526143 DOI: 10.1037/1064-1297.6.1.22  0.411
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