Amy F. Arnsten - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
prefrontal cortex, neuromodulators
Website:
http://medicine.yale.edu/lab/arnsten/

117 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Arnsten AFT. A Closer Look: Electron microscopic insights into aging glutamate synapses in the prefrontal association cortex. Neuroscience. PMID 30366027 DOI: 10.1016/j.neuroscience.2018.10.024  0.56
2018 Tebbenkamp ATN, Varela L, Choi J, Paredes MI, Giani AM, Song JE, Sestan-Pesa M, Franjic D, Sousa AMM, Liu ZW, Li M, Bichsel C, Koch M, Szigeti-Buck K, Liu F, ... ... Arnsten AFT, et al. The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development. Cell. PMID 30318146 DOI: 10.1016/j.cell.2018.09.014  1
2018 Galvin VC, Arnsten AFT, Wang M. Evolution in Neuromodulation-The Differential Roles of Acetylcholine in Higher Order Association vs. Primary Visual Cortices. Frontiers in Neural Circuits. 12: 67. PMID 30210306 DOI: 10.3389/fncir.2018.00067  1
2018 Constantinidis C, Funahashi S, Lee D, Murray JD, Qi XL, Wang M, Arnsten AFT. Persistent Spiking Activity Underlies Working Memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 38: 7020-7028. PMID 30089641 DOI: 10.1523/JNEUROSCI.2486-17.2018  1
2018 Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, et al. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging. Jama Neurology. PMID 30014145 DOI: 10.1001/jamaneurol.2018.1836  0.56
2018 Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial. Neurobiology of Aging. 70: 117-124. PMID 30007160 DOI: 10.1016/j.neurobiolaging.2018.05.033  0.56
2018 Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J. The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline. Current Biology : Cb. PMID 29576474 DOI: 10.1016/j.cub.2018.02.047  0.44
2018 Datta D, Arnsten AFT. Unique Molecular Regulation of Higher-Order Prefrontal Cortical Circuits: Insights into the Neurobiology of Schizophrenia. Acs Chemical Neuroscience. PMID 29470055 DOI: 10.1021/acschemneuro.7b00505  0.52
2018 Yang ST, Wang M, Paspalas CD, Crimins JL, Altman MT, Mazer JA, Arnsten AFT. Core Differences in Synaptic Signaling Between Primary Visual and Dorsolateral Prefrontal Cortex. Cerebral Cortex (New York, N.Y. : 1991). PMID 29351585 DOI: 10.1093/cercor/bhx357  1
2017 Paspalas CD, Carlyle BC, Leslie S, Preuss TM, Crimins JL, Huttner AJ, van Dyck CH, Rosene DL, Nairn AC, Arnsten AFT. The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29241829 DOI: 10.1016/j.jalz.2017.11.005  1
2017 Arnsten AFT, Lee D, Pittenger C. Risky Business: The Circuits that Impact Stress-Induced Decision-Making. Cell. 171: 992-993. PMID 29149614 DOI: 10.1016/j.cell.2017.11.004  0.76
2017 Sun Y, Yang Y, Galvin VC, Yang S, Arnsten AF, Wang M. Nicotinic α4β2 cholinergic receptor influences on dorsolateral prefrontal cortical neuronal firing during a working memory task. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28450546 DOI: 10.1523/JNEUROSCI.0364-17.2017  1
2017 Jin LE, Wang M, Galvin VC, Lightbourne TC, Conn PJ, Arnsten AF, Paspalas CD. mGluR2 versus mGluR3 Metabotropic Glutamate Receptors in Primate Dorsolateral Prefrontal Cortex: Postsynaptic mGluR3 Strengthen Working Memory Networks. Cerebral Cortex (New York, N.Y. : 1991). PMID 28108498 DOI: 10.1093/cercor/bhx005  1
2016 Morozov YM, Datta D, Paspalas CD, Arnsten AF. Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex. Neurobiology of Aging. 51: 9-18. PMID 28027494 DOI: 10.1016/j.neurobiolaging.2016.12.001  1
2016 Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, et al. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biological Psychiatry. 80: 84-6. PMID 27346079 DOI: 10.1016/j.biopsych.2016.05.004  0.48
2016 Arnsten AF, Murray JD, Seo H, Lee D. Ketamine's Antidepressant Actions: Potential Mechanisms in the Primate Medial Prefrontal Circuits That Represent Aversive Experience. Biological Psychiatry. 79: 713-5. PMID 27079495 DOI: 10.1016/j.biopsych.2016.02.014  0.76
2016 Arnsten AF, Girgis RR, Gray DL, Mailman RB. Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia. Biological Psychiatry. PMID 26946382 DOI: 10.1016/j.biopsych.2015.12.028  1
2016 Arnsten AF, Wang M. Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders. Annual Review of Pharmacology and Toxicology. 56: 339-60. PMID 26738476 DOI: 10.1146/annurev-pharmtox-010715-103617  1
2015 Wang M, Arnsten AF. Physiological approaches to understanding molecular actions on dorsolateral prefrontal cortical neurons underlying higher cognitive processing. Dong Wu Xue Yan Jiu = Zoological Research / "Dong Wu Xue Yan Jiu" Bian Ji Wei Yuan Hui Bian Ji. 36: 314-8. PMID 26646567  1
2015 Arnsten AF, Wang M, Paspalas CD. Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders. Pharmacological Reviews. 67: 681-96. PMID 26106146 DOI: 10.1124/pr.115.010512  1
2015 Wang M, Arnsten AF. Contribution of NMDA receptors to dorsolateral prefrontal cortical networks in primates. Neuroscience Bulletin. 31: 191-7. PMID 25754145 DOI: 10.1007/s12264-014-1504-6  1
2015 Gamo NJ, Lur G, Higley MJ, Wang M, Paspalas CD, Vijayraghavan S, Yang Y, Ramos BP, Peng K, Kata A, Boven L, Lin F, Roman L, Lee D, Arnsten AF. Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions with Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. Biological Psychiatry. PMID 25731884 DOI: 10.1016/j.biopsych.2015.01.009  1
2015 Hains AB, Yabe Y, Arnsten AF. Chronic Stimulation of Alpha-2A-Adrenoceptors With Guanfacine Protects Rodent Prefrontal Cortex Dendritic Spines and Cognition From the Effects of Chronic Stress. Neurobiology of Stress. 2: 1-9. PMID 25664335 DOI: 10.1016/j.ynstr.2015.01.001  1
2015 McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten AF, Picciotto MR, Weinberger AH, Ashare R, Sinha R. A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. Journal of Psychopharmacology (Oxford, England). 29: 300-11. PMID 25516371 DOI: 10.1177/0269881114562091  1
2015 Arnsten AF, Raskind MA, Taylor FB, Connor DF. The Effects of Stress Exposure on Prefrontal Cortex: Translating Basic Research into Successful Treatments for Post-Traumatic Stress Disorder. Neurobiology of Stress. 1: 89-99. PMID 25436222 DOI: 10.1016/j.ynstr.2014.10.002  1
2015 Connor DF, Ford JD, Arnsten AF, Greene CA. An Update on Posttraumatic Stress Disorder in Children and Adolescents. Clinical Pediatrics. 54: 517-28. PMID 24990362 DOI: 10.1177/0009922814540793  1
2014 Connor DF, Arnsten AF, Pearson GS, Greco GF. Guanfacine extended release for the treatment of attention-deficit/hyperactivity disorder in children and adolescents. Expert Opinion On Pharmacotherapy. 15: 1601-10. PMID 24992513 DOI: 10.1517/14656566.2014.930437  1
2014 Carlyle BC, Nairn AC, Wang M, Yang Y, Jin LE, Simen AA, Ramos BP, Bordner KA, Craft GE, Davies P, Pletikos M, Šestan N, Arnsten AF, Paspalas CD. cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Proceedings of the National Academy of Sciences of the United States of America. 111: 5036-41. PMID 24707050 DOI: 10.1073/pnas.1322360111  1
2014 El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. Biological Psychiatry. 76: 476-85. PMID 24560582 DOI: 10.1016/j.biopsych.2013.12.019  1
2014 Arnsten AF, Jin LE. Molecular influences on working memory circuits in dorsolateral prefrontal cortex. Progress in Molecular Biology and Translational Science. 122: 211-31. PMID 24484703 DOI: 10.1016/B978-0-12-420170-5.00008-8  1
2013 Gamo NJ, Duque A, Paspalas CD, Kata A, Fine R, Boven L, Bryan C, Lo T, Anighoro K, Bermudez L, Peng K, Annor A, Raja A, Mansson E, Taylor SR, ... ... Arnsten AF, et al. Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction. Translational Psychiatry. 3: e328. PMID 24301646 DOI: 10.1038/tp.2013.104  1
2013 Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M. Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 110: 12078-83. PMID 23818597 DOI: 10.1073/pnas.1307849110  1
2013 Wang M, Yang Y, Wang CJ, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang XJ, Arnsten AF. NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Neuron. 77: 736-49. PMID 23439125 DOI: 10.1016/j.neuron.2012.12.032  1
2013 Berridge CW, Arnsten AF. Psychostimulants and motivated behavior: arousal and cognition. Neuroscience and Biobehavioral Reviews. 37: 1976-84. PMID 23164814 DOI: 10.1016/j.neubiorev.2012.11.005  1
2013 Paspalas CD, Wang M, Arnsten AF. Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia. Cerebral Cortex (New York, N.Y. : 1991). 23: 1643-54. PMID 22693343 DOI: 10.1093/cercor/bhs152  1
2013 Arnsten A. Essential Catecholamine Influences on Dorsolateral Prefrontal Cortical Cognitive Function: Molecular Signaling Pathways Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 166-167. DOI: 10.1016/B978-0-12-800044-1.00147-1  1
2012 Caetano MS, Jin LE, Harenberg L, Stachenfeld KL, Arnsten AF, Laubach M. Noradrenergic control of error perseveration in medial prefrontal cortex. Frontiers in Integrative Neuroscience. 6: 125. PMID 23293590 DOI: 10.3389/fnint.2012.00125  1
2012 Arnsten AF, Wang MJ, Paspalas CD. Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron. 76: 223-39. PMID 23040817 DOI: 10.1016/j.neuron.2012.08.038  1
2012 Arnsten A, Mazure CM, Sinha R. This is your brain in meltdown. Scientific American. 306: 48-53. PMID 22486116 DOI: 10.1038/scientificamerican0412-48  1
2012 Arnsten AF, Jin LE. Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale. The Yale Journal of Biology and Medicine. 85: 45-58. PMID 22461743  1
2012 Arnsten AF, Rubia K. Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders. Journal of the American Academy of Child and Adolescent Psychiatry. 51: 356-67. PMID 22449642 DOI: 10.1016/j.jaac.2012.01.008  1
2012 Caetano MS, Horst NK, Harenberg L, Liu B, Arnsten AF, Laubach M. Lost in transition: aging-related changes in executive control by the medial prefrontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3765-77. PMID 22423097 DOI: 10.1523/JNEUROSCI.6011-11.2012  1
2012 Kim S, Bobeica I, Gamo NJ, Arnsten AF, Lee D. Effects of α-2A adrenergic receptor agonist on time and risk preference in primates. Psychopharmacology. 219: 363-75. PMID 21979441 DOI: 10.1007/s00213-011-2520-0  1
2012 Arnsten A, Mazure CM, Sinha R. This is your brain in meltdown Scientific American. 306: 38-43.  1
2011 Wang M, Gamo NJ, Yang Y, Jin LE, Wang XJ, Laubach M, Mazer JA, Lee D, Arnsten AF. Neuronal basis of age-related working memory decline. Nature. 476: 210-3. PMID 21796118 DOI: 10.1038/nature10243  1
2011 Arnsten AF, Casey BJ. Prefrontal cortical organization and function: implications for externalizing disorders. Biological Psychiatry. 69: 1131-2. PMID 21640860 DOI: 10.1016/j.biopsych.2011.03.010  1
2011 Gamo NJ, Arnsten AF. Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders. Behavioral Neuroscience. 125: 282-96. PMID 21480691 DOI: 10.1037/a0023165  1
2010 Gamo NJ, Wang M, Arnsten AF. Methylphenidate and atomoxetine enhance prefrontal function through α2-adrenergic and dopamine D1 receptors. Journal of the American Academy of Child and Adolescent Psychiatry. 49: 1011-23. PMID 20855046 DOI: 10.1016/j.jaac.2010.06.015  1
2010 Arnsten AF, Paspalas CD, Gamo NJ, Yang Y, Wang M. Dynamic Network Connectivity: A new form of neuroplasticity. Trends in Cognitive Sciences. 14: 365-75. PMID 20554470 DOI: 10.1016/j.tics.2010.05.003  1
2009 Simen AA, DiLeone R, Arnsten AF. Primate models of schizophrenia: future possibilities. Progress in Brain Research. 179: 117-25. PMID 20302824 DOI: 10.1016/S0079-6123(09)17913-X  1
2009 Hains AB, Vu MA, Maciejewski PK, van Dyck CH, Gottron M, Arnsten AF. Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress. Proceedings of the National Academy of Sciences of the United States of America. 106: 17957-62. PMID 19805148 DOI: 10.1073/pnas.0908563106  1
2009 Robbins TW, Arnsten AF. The neuropsychopharmacology of fronto-executive function: monoaminergic modulation. Annual Review of Neuroscience. 32: 267-87. PMID 19555290 DOI: 10.1146/annurev.neuro.051508.135535  1
2009 Paspalas CD, Selemon LD, Arnsten AF. Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex. Cerebral Cortex (New York, N.Y. : 1991). 19: 2145-55. PMID 19153107 DOI: 10.1093/cercor/bhn235  1
2009 Barch DM, Carter CS, Arnsten A, Buchanan RW, Cohen JD, Geyer M, Green MF, Krystal JH, Nuechterlein K, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R. Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: proceedings of the third CNTRICS meeting. Schizophrenia Bulletin. 35: 109-14. PMID 19023126 DOI: 10.1093/schbul/sbn163  1
2009 Shansky RM, Bender G, Arnsten AF. Estrogen prevents norepinephrine alpha-2a receptor reversal of stress-induced working memory impairment. Stress (Amsterdam, Netherlands). 12: 457-63. PMID 19005873 DOI: 10.1080/10253890802520988  1
2008 Budel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S, Lauren J, Park JH, McGee AW, Liao J, Stillman A, Kim JE, Yang BZ, Sodi S, Gelernter J, ... ... Arnsten AF, et al. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13161-72. PMID 19052207 DOI: 10.1523/JNEUROSCI.3828-08.2008  1
2008 Hains AB, Arnsten AF. Molecular mechanisms of stress-induced prefrontal cortical impairment: implications for mental illness. Learning & Memory (Cold Spring Harbor, N.Y.). 15: 551-64. PMID 18685145 DOI: 10.1101/lm.921708  1
2008 Brennan AR, Dolinsky B, Vu MA, Stanley M, Yeckel MF, Arnsten AF. Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory. Learning & Memory (Cold Spring Harbor, N.Y.). 15: 93-6. PMID 18285467 DOI: 10.1101/lm.767408  1
2008 Ramos BP, Colgan LA, Nou E, Arnsten AF. Beta2 adrenergic agonist, clenbuterol, enhances working memory performance in aging animals. Neurobiology of Aging. 29: 1060-9. PMID 17363115 DOI: 10.1016/j.neurobiolaging.2007.02.003  1
2008 van Dyck CH, Avery RA, MacAvoy MG, Marek KL, Quinlan DM, Baldwin RM, Seibyl JP, Innis RB, Arnsten AF. Striatal dopamine transporters correlate with simple reaction time in elderly subjects. Neurobiology of Aging. 29: 1237-46. PMID 17363113 DOI: 10.1016/j.neurobiolaging.2007.02.012  1
2007 Arnsten AF, Scahill L, Findling RL. alpha2-Adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: emerging concepts from new data. Journal of Child and Adolescent Psychopharmacology. 17: 393-406. PMID 17822336 DOI: 10.1089/cap.2006.0098  1
2007 Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell. 129: 397-410. PMID 17448997 DOI: 10.1016/j.cell.2007.03.015  1
2007 Ramos BP, Arnsten AF. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacology & Therapeutics. 113: 523-36. PMID 17303246 DOI: 10.1016/j.pharmthera.2006.11.006  1
2007 Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF. Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience. 10: 376-84. PMID 17277774 DOI: 10.1038/nn1846  1
2006 Ramos BP, Stark D, Verduzco L, van Dyck CH, Arnsten AF. Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals. Learning & Memory (Cold Spring Harbor, N.Y.). 13: 770-6. PMID 17101879 DOI: 10.1101/lm.298006  1
2006 Arnsten AF, Vijayraghavan S. Staying in touch with methylphenidate: AHDH and sensory processing. Focus on "methylphenidate enhances noradrenergic transmission and suppresses mid- and long-latency sensory responses in the primary somatosensory cortex of awake rats". Journal of Neurophysiology. 96: 524-5. PMID 16835361 DOI: 10.1152/jn.00373.2006  1
2006 Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AF, Kelley AE, Schmeichel B, Hamilton C, Spencer RC. Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biological Psychiatry. 60: 1111-20. PMID 16806100 DOI: 10.1016/j.biopsych.2006.04.022  1
2006 Shansky RM, Rubinow K, Brennan A, Arnsten AF. The effects of sex and hormonal status on restraint-stress-induced working memory impairment. Behavioral and Brain Functions : Bbf. 2: 8. PMID 16522198 DOI: 10.1186/1744-9081-2-8  1
2005 Ramos BP, Colgan L, Nou E, Ovadia S, Wilson SR, Arnsten AF. The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys. Biological Psychiatry. 58: 894-900. PMID 16043136 DOI: 10.1016/j.biopsych.2005.05.022  1
2005 Arnsten AF, Li BM. Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biological Psychiatry. 57: 1377-84. PMID 15950011 DOI: 10.1016/j.biopsych.2004.08.019  0.92
2005 Arnsten AF, Ramos BP, Birnbaum SG, Taylor JR. Protein kinase A as a therapeutic target for memory disorders: rationale and challenges. Trends in Molecular Medicine. 11: 121-8. PMID 15760770 DOI: 10.1016/j.molmed.2005.01.006  1
2005 Ma CL, Arnsten AF, Li BM. Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys. Biological Psychiatry. 57: 192-5. PMID 15652880 DOI: 10.1016/j.biopsych.2004.11.004  0.92
2004 Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, Arnsten AF. Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science (New York, N.Y.). 306: 882-4. PMID 15514161 DOI: 10.1126/science.1100021  1
2004 Arnsten AF, Shansky RM. Adolescence: vulnerable period for stress-induced prefrontal cortical function? Introduction to part IV. Annals of the New York Academy of Sciences. 1021: 143-7. PMID 15251883 DOI: 10.1196/annals.1308.017  1
2004 Shansky RM, Glavis-Bloom C, Lerman D, McRae P, Benson C, Miller K, Cosand L, Horvath TL, Arnsten AF. Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction. Molecular Psychiatry. 9: 531-8. PMID 14569273 DOI: 10.1038/sj.mp.4001435  1
2003 Ramos BP, Birnbaum SG, Lindenmayer I, Newton SS, Duman RS, Arnsten AF. Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline. Neuron. 40: 835-45. PMID 14622586 DOI: 10.1016/S0896-6273(03)00694-9  1
2002 Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF. Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8771-7. PMID 12351753  1
2001 Arnsten AF. Modulation of prefrontal cortical-striatal circuits: relevance to therapeutic treatments for Tourette syndrome and attention-deficit hyperactivity disorder. Advances in Neurology. 85: 333-41. PMID 11530441  1
2001 Scahill L, Chappell PB, Kim YS, Schultz RT, Katsovich L, Shepherd E, Arnsten AF, Cohen DJ, Leckman JF. A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. The American Journal of Psychiatry. 158: 1067-74. PMID 11431228 DOI: 10.1176/appi.ajp.158.7.1067  1
2000 Birnbaum SG, Podell DM, Arnsten AF. Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats. Pharmacology, Biochemistry, and Behavior. 67: 397-403. PMID 11164065 DOI: 10.1016/S0091-3057(00)00306-3  1
2000 Arnsten AF. Genetics of childhood disorders: XVIII. ADHD, Part. 2: Norepinephrine has a critical modulatory influence on prefrontal cortical function. Journal of the American Academy of Child and Adolescent Psychiatry. 39: 1201-3. PMID 10986819  1
2000 Avery RA, Franowicz JS, Studholme C, van Dyck CH, Arnsten AF. The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 23: 240-9. PMID 10942848 DOI: 10.1016/S0893-133X(00)00111-1  0.56
1999 Mao ZM, Li BM, Arnsten AF. [Roles of alpha-2 adrenoceptor in prefrontal cortical cognitive functions]. Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. 30: 17-22. PMID 12532843  1
1999 Birnbaum S, Gobeske KT, Auerbach J, Taylor JR, Arnsten AF. A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex. Biological Psychiatry. 46: 1266-74. PMID 10560032 DOI: 10.1016/S0006-3223(99)00138-9  1
1999 Mao ZM, Arnsten AF, Li BM. Local infusion of an alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys. Biological Psychiatry. 46: 1259-65. PMID 10560031  0.92
1999 Southwick SM, Bremner JD, Rasmusson A, Morgan CA, Arnsten A, Charney DS. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biological Psychiatry. 46: 1192-204. PMID 10560025 DOI: 10.1016/S0006-3223(99)00219-X  1
1999 Taylor JR, Birnbaum S, Ubriani R, Arnsten AF. Activation of cAMP-dependent protein kinase A in prefrontal cortex impairs working memory performance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: RC23. PMID 10479716  1
1999 Arnsten AF, Mathew R, Ubriani R, Taylor JR, Li BM. Alpha-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function. Biological Psychiatry. 45: 26-31. PMID 9894572  0.92
1998 Arnsten AF, Goldman-Rakic PS. Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism. Archives of General Psychiatry. 55: 362-8. PMID 9554432 DOI: 10.1001/archpsyc.55.4.362  1
1998 Arnsten AF, Steere JC, Jentsch DJ, Li BM. Noradrenergic influences on prefrontal cortical cognitive function: opposing actions at postjunctional alpha 1 versus alpha 2-adrenergic receptors. Advances in Pharmacology (San Diego, Calif.). 42: 764-7. PMID 9328010  1
1997 Steere JC, Arnsten AF. The alpha-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys. Behavioral Neuroscience. 111: 883-91. PMID 9383511  0.72
1997 Cai JX, Arnsten AF. Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys. The Journal of Pharmacology and Experimental Therapeutics. 283: 183-9. PMID 9336323  0.6
1997 Zahrt J, Taylor JR, Mathew RG, Arnsten AF. Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8528-35. PMID 9334425  0.56
1997 van Dyck CH, Lin CH, Robinson R, Cellar J, Smith EO, Nelson JC, Arnsten AF, Hoffer PB. The acetylcholine releaser linopirdine increases parietal regional cerebral blood flow in Alzheimer's disease. Psychopharmacology. 132: 217-26. PMID 9292621 DOI: 10.1007/s002130050339  1
1997 Leckman JF, Peterson BS, Anderson GM, Arnsten AF, Pauls DL, Cohen DJ. Pathogenesis of Tourette's syndrome. Journal of Child Psychology and Psychiatry, and Allied Disciplines. 38: 119-42. PMID 9232461 DOI: 10.1111/j.1469-7610.1997.tb01508.x  1
1997 Murphy BL, Roth RH, Arnsten AF. Clozapine reverses the spatial working memory deficits induced by FG7142 in monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 16: 433-7. PMID 9165499 DOI: 10.1016/S0893-133X(97)00019-5  1
1997 Arnsten AF, Lin CH, Van Dyck CH, Stanhope KJ. The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys. Neurobiology of Aging. 18: 21-8. PMID 8983029  0.56
1996 Murphy BL, Arnsten AF, Jentsch JD, Roth RH. Dopamine and spatial working memory in rats and monkeys: pharmacological reversal of stress-induced impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7768-75. PMID 8922432  1
1996 Arnsten AF, Steere JC, Hunt RD. The contribution of alpha 2-noradrenergic mechanisms of prefrontal cortical cognitive function. Potential significance for attention-deficit hyperactivity disorder. Archives of General Psychiatry. 53: 448-55. PMID 8624188  1
1996 Murphy BL, Arnsten AF, Goldman-Rakic PS, Roth RH. Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proceedings of the National Academy of Sciences of the United States of America. 93: 1325-9. PMID 8577763 DOI: 10.1073/pnas.93.3.1325  1
1995 Hunt RD, Arnsten AF, Asbell MD. An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 34: 50-4. PMID 7860456 DOI: 10.1097/00004583-199501000-00013  1
1995 Steere JC, Arnsten AF. Corpus callosum morphology in ADHD. The American Journal of Psychiatry. 152: 1105-6. PMID 7793463  0.72
1995 Arnsten AF, Cai JX, Steere JC, Goldman-Rakic PS. Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 3429-39. PMID 7751922  1
1994 Arnsten AF, Cai JX, Murphy BL, Goldman-Rakic PS. Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys. Psychopharmacology. 116: 143-51. PMID 7862943 DOI: 10.1007/BF02245056  1
1993 Berridge CW, Arnsten AF, Foote SL. Noradrenergic modulation of cognitive function: clinical implications of anatomical, electrophysiological and behavioural studies in animal models. Psychological Medicine. 23: 557-64. PMID 8234565  0.44
1993 Arnsten AF, Cai JX. Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: indirect effects of yohimbine versus direct effects of clonidine. Neurobiology of Aging. 14: 597-603. PMID 7905189  0.6
1991 Arnsten AF, Leslie FM. Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype. Neuropharmacology. 30: 1279-89. PMID 1686301 DOI: 10.1016/0028-3908(91)90024-6  1
1990 Arnsten AF, Goldman-Rakic PS. Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiology of Aging. 11: 583-90. PMID 1980719 DOI: 10.1016/0197-4580(90)90021-Q  1
1988 Arnsten AF, Cai JX, Goldman-Rakic PS. The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 4287-98. PMID 2903226  1
1987 Arnsten AF, Goldman-Rakic PS. Noradrenergic mechanisms in age-related cognitive decline. Journal of Neural Transmission. Supplementum. 24: 317-24. PMID 2824692  1
1985 Arnsten AF, Berridge C, Segal DS. Stress produces opioid-like effects on investigatory behavior. Pharmacology, Biochemistry, and Behavior. 22: 803-9. PMID 4011639 DOI: 10.1016/0091-3057(85)90531-3  1
1985 Arnsten AF, Goldman-Rakic PS. Catecholamines and cognitive decline in aged nonhuman primates. Annals of the New York Academy of Sciences. 444: 218-34. PMID 3925850  1
1985 Arnsten AF, Goldman-Rakic PS. Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science (New York, N.Y.). 230: 1273-6. PMID 2999977  1
1984 Arnsten AF, Neville HJ, Hillyard SA, Janowsky DS, Segal DS. Naloxone increases electrophysiological measures of selective information processing in humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 2912-9. PMID 6502211  1
1984 Arnsten AF, Goldman-Rakic PS. Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey. Brain Research. 306: 9-18. PMID 6466989 DOI: 10.1016/0006-8993(84)90351-2  1
1983 Arnsten AF, Segal DS, Neville HJ, Hillyard SA, Janowsky DS, Judd LL, Bloom FE. Naloxone augments electrophysiological signs of selective attention in man. Nature. 304: 725-7. PMID 6888538 DOI: 10.1038/304725a0  1
1981 Arnsten AF, Segal DS, Loughlin SE, Roberts DC. Evidence for an interaction of opioid and noradrenergic locus coeruleus systems in the regulation of environmental stimulus-directed behavior. Brain Research. 222: 351-63. PMID 7284783 DOI: 10.1016/0006-8993(81)91038-6  1
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