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Karen Hedin - Publications

Affiliations: 
Neurobiology of Disease College of Medicine - Mayo Clinic 
Area:
Cell Biology, Neuroscience Biology, Immunology
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sterner RM, Sakemura R, Yang N, Cox MJ, Khadka R, Forsman CL, Hansen MJ, Jin F, Ayasoufi K, Hefazi M, Welch BM, Schick KJ, Walters DK, Martinez G, Ahmed O, ... ... Hedin KE, et al. GM-CSF Blockade during Chimeric Antigen Receptor T-Cell (CART) Therapy Reduces Cytokine Release Syndrome and Neurotoxicity and May Enhance CART Effector Functions Biology of Blood and Marrow Transplantation. 25: S4. DOI: 10.1016/J.Bbmt.2018.12.686  0.409
2018 Sterner RM, Sakemura R, Cox MJ, Yang N, Khadka RH, Forsman CL, Hansen MJ, Jin F, Ayasoufi K, Hefazi M, Schick KJ, Walters DK, Ahmed O, Chappell D, Sahmoud T, ... ... Hedin KE, et al. GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts. Blood. PMID 30463995 DOI: 10.1182/Blood-2018-10-881722  0.374
2018 Dinkel BA, Kremer KN, Rollins MR, Medlyn MJ, Hedin KE. GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation which drives PI3Kγ/PREX1 signaling and T cell cytokine secretion. The Journal of Biological Chemistry. PMID 30018141 DOI: 10.1074/jbc.RA118.003097  0.588
2018 Sterner RM, Kremer KN, Dudakovic A, Westendorf JJ, van Wijnen AJ, Hedin KE. Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis. Journal of Immunology (Baltimore, Md. : 1950). PMID 29914885 DOI: 10.4049/jimmunol.1800174  0.33
2018 Sterner RM, Sakemura R, Yang N, Cox MJ, Khadka RH, Forsman CL, Hansen MJ, Jin F, Ayasoufi K, Hefazi M, Welch BM, Schick KJ, Walters DK, Martinez G, Ahmed O, ... ... Hedin KE, et al. GM-CSF Blockade during Chimeric Antigen Receptor T Cell Therapy Reduces Cytokine Release Syndrome and Neurotoxicity and May Enhance Their Effector Functions Blood. 132: 961-961. DOI: 10.1182/Blood-2018-99-111766  0.389
2018 Bowles B, Sterner RM, Kremer KN, Dudakovic A, Westendorf JJ, Van Wijnen AJ, Hedin KE. 2559 Role of tissue non-specific alkaline phosphatase (TNAP) in promoting the survival of acute myeloid leukemia (AML) cells within the bone marrow microenvironment Journal of Clinical and Translational Science. 2: 26-27. DOI: 10.1017/cts.2018.119  0.307
2017 Kremer KN, Dinkel BA, Sterner RM, Osborne DG, Jevremovic D, Hedin KE. TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL. Blood. PMID 28694325 DOI: 10.1182/Blood-2017-03-770982  0.344
2016 Sterner R, Kremer K, Dudakovic A, Kaufmann S, Westendorf J, Wijnen Av, Hedin K. Abstract 3292: Manipulating osteoblast differentiation in order to inhibit protection of AML cells within the bone marrow Cancer Research. 76: 3292-3292. DOI: 10.1158/1538-7445.Am2016-3292  0.37
2015 Kremer KN, Dudakovic A, Hess AD, Smith BD, Karp JE, Kaufmann SH, Westendorf JJ, van Wijnen AJ, Hedin KE. Histone deacetylase inhibitors target the leukemic microenvironment by enhancing a Nherf1-Protein Phosphatase 1α-TAZ signaling pathway in osteoblasts. The Journal of Biological Chemistry. PMID 26491017 DOI: 10.1074/Jbc.M115.668160  0.455
2015 Bamidele AO, Kremer KN, Hirsova P, Clift IC, Gores GJ, Billadeau DD, Hedin KE. IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes. The Journal of Cell Biology. 210: 257-72. PMID 26195666 DOI: 10.1083/Jcb.201411045  0.643
2014 Kremer KN, Dudakovic A, McGee-Lawrence ME, Philips RL, Hess AD, Smith BD, van Wijnen AJ, Karp JE, Kaufmann SH, Westendorf JJ, Hedin KE. Osteoblasts protect AML cells from SDF-1-induced apoptosis. Journal of Cellular Biochemistry. 115: 1128-37. PMID 24851270 DOI: 10.1002/Jcb.24755  0.34
2014 Kim J, Shapiro MJ, Bamidele AO, Gurel P, Thapa P, Higgs HN, Hedin KE, Shapiro VS, Billadeau DD. Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse. Plos One. 9: e85090. PMID 24454796 DOI: 10.1371/Journal.Pone.0085090  0.346
2014 Clift IC, Bamidele AO, Rodriguez-Ramirez C, Kremer KN, Hedin KE. β-Arrestin1 and distinct CXCR4 structures are required for stromal derived factor-1 to downregulate CXCR4 cell-surface levels in neuroblastoma. Molecular Pharmacology. 85: 542-52. PMID 24452472 DOI: 10.1124/Mol.113.089714  0.634
2013 Kremer KN, Peterson KL, Schneider PA, Meng XW, Dai H, Hess AD, Smith BD, Rodriguez-Ramirez C, Karp JE, Kaufmann SH, Hedin KE. CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. The Journal of Biological Chemistry. 288: 22899-914. PMID 23798675 DOI: 10.1074/Jbc.M113.449926  0.398
2011 Kremer KN, Kumar A, Hedin KE. G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. Journal of Immunology (Baltimore, Md. : 1950). 187: 3177-85. PMID 21856938 DOI: 10.4049/jimmunol.1100206  0.573
2011 Kremer KN, Clift IC, Miamen AG, Bamidele AO, Qian NX, Humphreys TD, Hedin KE. Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responses. Journal of Immunology (Baltimore, Md. : 1950). 187: 1440-7. PMID 21705626 DOI: 10.4049/Jimmunol.1100820  0.627
2011 Erskine CL, Krco CJ, Hedin KE, Borson ND, Kalli KR, Behrens MD, Heman-Ackah SM, von Hofe E, Wettstein PJ, Mohamadzadeh M, Knutson KL. MHC class II epitope nesting modulates dendritic cell function and improves generation of antigen-specific CD4 helper T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 316-24. PMID 21613617 DOI: 10.4049/Jimmunol.1100658  0.326
2011 Kumar A, Kremer KN, Dominguez D, Tadi M, Hedin KE. Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation. Journal of Immunology (Baltimore, Md. : 1950). 186: 951-8. PMID 21148034 DOI: 10.4049/jimmunol.1002019  0.63
2009 Kumar A, Kremer KN, Sims OL, Hedin KE. Measuring the proximity of T-lymphocyte CXCR4 and TCR by fluorescence resonance energy transfer (FRET). Methods in Enzymology. 460: 379-97. PMID 19446736 DOI: 10.1016/S0076-6879(09)05219-7  0.406
2007 Kremer KN, Kumar A, Hedin KE. Haplotype-independent costimulation of IL-10 secretion by SDF-1/CXCL12 proceeds via AP-1 binding to the human IL-10 promoter. Journal of Immunology (Baltimore, Md. : 1950). 178: 1581-8. PMID 17237407  0.313
2007 Alsayed Y, Ngo H, Runnels J, Leleu X, Singha UK, Pitsillides CM, Spencer JA, Kimlinger T, Ghobrial JM, Jia X, Lu G, Timm M, Kumar A, Côté D, Veilleux I, ... Hedin KE, et al. Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma. Blood. 109: 2708-17. PMID 17119115 DOI: 10.1182/Blood-2006-07-035857  0.414
2006 Billadeau DD, Chatterjee S, Bramati P, Sreekumar R, Shah V, Hedin K, Urrutia R. Characterization of the CXCR4 signaling in pancreatic cancer cells. International Journal of Gastrointestinal Cancer. 37: 110-9. PMID 18175225 DOI: 10.1007/S12029-007-0011-7  0.502
2006 Kumar A, Humphreys TD, Kremer KN, Bramati PS, Bradfield L, Edgar CE, Hedin KE. CXCR4 physically associates with the T cell receptor to signal in T cells. Immunity. 25: 213-24. PMID 16919488 DOI: 10.1016/j.immuni.2006.06.015  0.52
2004 Ghobrial IM, Bone ND, Stenson MJ, Novak A, Hedin KE, Kay NE, Ansell SM. Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma. Mayo Clinic Proceedings. 79: 318-25. PMID 15008605 DOI: 10.4065/79.3.318  0.372
2004 Ghobrial IM, Ghobrial JM, Bramati P, Kimlinger T, Timm MM, Kumar A, Hedin KE, Witzig TE. Molecular Mechanisms Involved in Homing and Migration of Plasma Cells in Response to CXCR4 Stimulation and Downstream Activation of the PI3K Pathway. Blood. 104: 2188-2188. DOI: 10.1182/blood.v104.11.2188.2188  0.461
2004 Ghobrial IM, Ghobrial JM, Bramati P, Timm MM, Kumar A, Witzig TE, Kay N, Hedin KE. Molecular Mechanisms Involved in Homing and Migration of B-Chronic Lymphocytic Leukemia (CLL) in Response to CXCR4 Stimulation and Downstream Activation of the PI3K Pathway. Blood. 104: 1909-1909. DOI: 10.1182/blood.v104.11.1909.1909  0.519
2004 Ghobrial IM, Bone ND, Stenson MJ, Novak A, Hedin KE, Kay NE, Ansell SM. Expression of the Chemokine Receptors CXCR4 and CCR7 and Disease Progression in B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Mayo Clinic Proceedings. 79: 318-325.  0.327
2003 Kremer KN, Humphreys TD, Kumar A, Qian NX, Hedin KE. Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1 alpha/CXCL12 chemokine. Journal of Immunology (Baltimore, Md. : 1950). 171: 360-7. PMID 12817019  0.457
2002 Hedin KE. Chemokines: new, key players in the pathobiology of pancreatic cancer. International Journal of Gastrointestinal Cancer. 31: 23-9. PMID 12622412 DOI: 10.1385/IJGC:31:1-3:23  0.359
2000 Ellenrieder V, Kaczynski JA, Hedin K, Urrutia R. Detailed domain structure and MAP kinase-mediated phosphorylation of the growth suppressor transcription factor, TIEG2 Gastroenterology. 118: A639. DOI: 10.1016/S0016-5085(00)84693-4  0.329
1999 Hedin KE, Bell MP, Huntoon CJ, Karnitz LM, McKean DJ. G(i) proteins use a novel βγ- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in jurkat T lymphocytes Journal of Biological Chemistry. 274: 19992-20001. PMID 10391949 DOI: 10.1074/jbc.274.28.19992  0.518
1997 Hedin KE, Bell MP, Kalli KR, Huntoon CJ, Sharp BM, McKean DJ. δ-Opioid Receptors Expressed by Jurkat T Cells Enhance IL-2 Secretion by Increasing AP-1 Complexes and Activity of the NF-AT/AP-1-Binding Promoter Element Journal of Immunology. 159: 5431-5440. PMID 9548483  0.345
1993 Hedin KE, Duerson K, Clapham DE. Specificity of receptor-G protein interactions: searching for the structure behind the signal. Cellular Signalling. 5: 505-18. PMID 8312128 DOI: 10.1016/0898-6568(93)90046-O  0.366
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