Tsuneya Ikezu - Publications

Affiliations: 
Neuroscience GMS Boston University, Boston, MA, United States 
Area:
Neuroscience Biology, Molecular Biology, Pharmacy

96 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 You Y, Ikezu T. Emerging roles of extracellular vesicles in neurodegenerative disorders. Neurobiology of Disease. 104512. PMID 31229685 DOI: 10.1016/j.nbd.2019.104512  0.44
2018 Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, ... ... Ikezu T, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles. 7: 1535750. PMID 30637094 DOI: 10.1080/20013078.2018.1535750  1
2018 Yeh H, Ikezu T. Transcriptional and Epigenetic Regulation of Microglia in Health and Disease. Trends in Molecular Medicine. PMID 30578089 DOI: 10.1016/j.molmed.2018.11.004  0.92
2018 Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathologica. PMID 30465259 DOI: 10.1007/s00401-018-1937-5  1
2018 Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 29516269 DOI: 10.1007/s11481-018-9781-x  1
2018 Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, ... ... Ikezu T, et al. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nature Neuroscience. 21: 72-80. PMID 29273772 DOI: 10.1038/s41593-017-0022-z  1
2017 Clayton KA, Van Enoo AA, Ikezu T. Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy. Frontiers in Neuroscience. 11: 680. PMID 29311768 DOI: 10.3389/fnins.2017.00680  1
2017 DeLeo AM, Ikezu T. Extracellular Vesicle Biology in Alzheimer's Disease and Related Tauopathy. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 29185187 DOI: 10.1007/s11481-017-9768-z  1
2017 Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, ... ... Ikezu T, et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 47: 566-581.e9. PMID 28930663 DOI: 10.1016/j.immuni.2017.08.008  1
2017 Varnum MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, Koro L, Ikezu S, Ikezu T. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. The Journal of Biological Chemistry. PMID 28490631 DOI: 10.1074/jbc.M116.759159  1
2016 Wolozin B, Ikezu T. Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591]. Ebiomedicine. 8: 349. PMID 27428444 DOI: 10.1016/j.ebiom.2016.05.033  1
2016 Stern RA, Tripodis Y, Baugh CM, Fritts NG, Martin BM, Chaisson C, Cantu RC, Joyce JA, Shah S, Ikezu T, Zhang J, Gercel-Taylor C, Taylor DD. Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy. Journal of Alzheimer's Disease : Jad. PMID 26890775 DOI: 10.3233/JAD-151028  1
2016 Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nature Communications. 7: 10332. PMID 26755131 DOI: 10.1038/ncomms10332  1
2016 Wolozin B, Ikezu T. Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 1590-1591] Ebiomedicine. 8: 349. DOI: 10.1016/j.ebiom.2016.05.033  1
2015 Wolozin B, Ikezu T. Syk and Yea Shall Find. Ebiomedicine. 2: 1590-1. PMID 26870779 DOI: 10.1016/j.ebiom.2015.11.012  1
2015 Sapkota K, Mao Z, Synowicki P, Lieber D, Liu M, Ikezu T, Gautam V, Monaghan DT. GluN2D NMDAR subunit contribution to the stimulation of brain activity and gamma oscillations by ketamine; implications for schizophrenia. The Journal of Pharmacology and Experimental Therapeutics. PMID 26675679 DOI: 10.1124/jpet.115.230391  1
2015 Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature Neuroscience. 18: 1584-93. PMID 26436904 DOI: 10.1038/nn.4132  1
2015 Varnum MM, Kiyota T, Ingraham KL, Ikezu S, Ikezu T. The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease. Neurobiology of Aging. 36: 2995-3007. PMID 26315370 DOI: 10.1016/j.neurobiolaging.2015.07.027  1
2015 Woodbury ME, Freilich RW, Cheng CJ, Asai H, Ikezu S, Boucher JD, Slack F, Ikezu T. miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9764-81. PMID 26134658 DOI: 10.1523/JNEUROSCI.4790-14.2015  1
2015 Ikezu T. The Use of Viral Vectors to Enhance Cognition Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors. 111-137. DOI: 10.1016/B978-0-12-417042-1.00006-1  1
2015 Woodbury M, Kiyota T, Ikezu T. Gene delivery and gene therapy for Alzheimer’s disease Neuromethods. 98: 85-120. DOI: 10.1007/978-1-4939-2306-9_4  1
2014 Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, ... ... Ikezu T, et al. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Annals of Neurology. 76: 379-92. PMID 25043464 DOI: 10.1002/ana.24219  1
2014 Ikezu S, Ikezu T. Tau-tubulin kinase. Frontiers in Molecular Neuroscience. 7: 33. PMID 24808823 DOI: 10.3389/fnmol.2014.00033  1
2014 Asai H, Ikezu S, Woodbury ME, Yonemoto GM, Cui L, Ikezu T. Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1. The American Journal of Pathology. 184: 808-18. PMID 24418258 DOI: 10.1016/j.ajpath.2013.11.026  1
2014 Woodbury ME, Ikezu T. Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 9: 92-101. PMID 24057103 DOI: 10.1007/s11481-013-9501-5  1
2013 Freilich RW, Woodbury ME, Ikezu T. Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia. Plos One. 8: e79416. PMID 24244499 DOI: 10.1371/journal.pone.0079416  1
2013 Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, et al. Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. The American Journal of Pathology. 183: 369-81. PMID 23747948 DOI: 10.1016/j.ajpath.2013.05.005  1
2013 McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, ... ... Ikezu T, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain : a Journal of Neurology. 136: 43-64. PMID 23208308 DOI: 10.1093/brain/aws307  1
2013 Tokuraku K, Ikezu T. Imaging of Amyloidβ Aggregation Using a Novel Quantum dot Nanoprobe and its Advanced Applications Bio-Nanoimaging: Protein Misfolding and Aggregation. 121-131. DOI: 10.1016/B978-0-12-394431-3.00011-0  1
2012 Varnum MM, Ikezu T. The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Archivum Immunologiae Et Therapiae Experimentalis. 60: 251-66. PMID 22710659 DOI: 10.1007/s00005-012-0181-2  1
2012 Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8270-83. PMID 22699908 DOI: 10.1523/JNEUROSCI.1592-12.2012  1
2012 Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, ... ... Ikezu T, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Science Translational Medicine. 4: 134ra60. PMID 22593173 DOI: 10.1126/scitranslmed.3003716  1
2012 Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 29: 329-40. PMID 22232014 DOI: 10.3233/JAD-2011-111472  1
2012 Kiyota T, Ingraham KL, Swan RJ, Jacobsen MT, Andrews SJ, Ikezu T. AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APPPS1 mice Gene Therapy. 19: 724-733. PMID 21918553 DOI: 10.1038/gt.2011.126  1
2012 Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T. The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal model. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 412-23. PMID 21826404 DOI: 10.1007/s11481-011-9304-5  1
2011 Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu T. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders. Proceedings of the National Academy of Sciences of the United States of America. 108: E1339-48. PMID 22042871 DOI: 10.1073/pnas.1102349108  1
2011 Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T. HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. Journal of Immunology (Baltimore, Md. : 1950). 186: 6925-32. PMID 21551363 DOI: 10.4049/jimmunol.1100211  1
2011 Freilich RW, Ikezu T. Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 6: 41-56. PMID 21103946 DOI: 10.1007/s11481-010-9250-7  1
2011 Xu J, Tsutsumi K, Tokuraku K, Estes KA, Hisanaga S, Ikezu T. Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity. Journal of Neurochemistry. 116: 192-204. PMID 20492361 DOI: 10.1111/j.1471-4159.2010.06824.x  1
2011 Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu T. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders (Proceedings of the National Academy of Sciences of the United States of America (2011), 108, (E1339-E1348) DOI: 10.1073/pnas.1102349108) Proceedings of the National Academy of Sciences of the United States of America. 108: 21282. DOI: 10.1073/pnas.1119280109  1
2011 Yamamoto M, Ikezu T. CCR2 chemokine receptor Xpharm: the Comprehensive Pharmacology Reference. 1-7. DOI: 10.1016/B978-008055232-3.60187-4  1
2011 Yamamoto M, Ikezu T. CCR1 chemokine receptor Xpharm: the Comprehensive Pharmacology Reference. 1-10. DOI: 10.1016/B978-008055232-3.60185-0  1
2010 Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers. Journal of Medicinal Chemistry. 53: 7992-9. PMID 21038854 DOI: 10.1021/jm1006929  1
2010 Tokuraku K, Okuyama S, Matsushima K, Ikezu T, Kotani S. Distinct neuronal localization of microtubule-associated protein 4 in the mammalian brain. Neuroscience Letters. 484: 143-7. PMID 20727942 DOI: 10.1016/j.neulet.2010.08.038  1
2010 Kiyota T, Okuyama S, Swan RJ, Jacobsen MT, Gendelman HE, Ikezu T. CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 3093-102. PMID 20371618 DOI: 10.1096/fj.10-155317  1
2010 Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2904-15. PMID 20354135 DOI: 10.1096/fj.09-150144  1
2009 Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, β-amyloidosis, and Learning Impairment of APP/PS1 Mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 803-809. PMID 28189021 DOI: 10.1038/mt.2009.44  1
2009 Tokuraku K, Marquardt M, Ikezu T. Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes. Plos One. 4: e8492. PMID 20041162 DOI: 10.1371/journal.pone.0008492  1
2009 Kiyota T, Yamamoto M, Xiong H, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. Plos One. 4: e6197. PMID 19593388 DOI: 10.1371/journal.pone.0006197  1
2009 Ikezu T. The aging of human-immunodeficiency-virus-associated neurocognitive disorders. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 161-2. PMID 19415503 DOI: 10.1007/s11481-009-9155-5  1
2009 Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 803-9. PMID 19277012 DOI: 10.1038/mt.2009.44  1
2009 Buescher JL, Martinez LB, Sato S, Okuyama S, Ikezu T. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 103-15. PMID 19034670 DOI: 10.1007/s11481-008-9139-x  1
2009 Martinez LB, Walsh SM, Jacobsen MT, Sato S, Wiederin J, Ciborowski P, Ikezu T. Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 116-28. PMID 19034669 DOI: 10.1007/s11481-008-9140-4  1
2009 Xu J, Ikezu T. The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 200-12. PMID 19016329 DOI: 10.1007/s11481-008-9136-0  1
2009 Padala KP, Potter JF, Ikezu T. HMGCoA-reductase inhibitors in dementia: Benefit or harm Clinical Medicine: Geriatrics. 2009: 13-22.  1
2008 Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14511-21. PMID 19118186 DOI: 10.1523/JNEUROSCI.3417-08.2008  1
2008 Buescher JL, Duan F, Sun J, Price RW, Ikezu T. OTK18 levels in plasma and cerebrospinal fluid correlate with viral load and CD8 T-cells in normal and AIDS patients. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 3: 230-5. PMID 18773297 DOI: 10.1007/s11481-008-9125-3  1
2008 Yamamoto M, Kiyota T, Walsh SM, Liu J, Kipnis J, Ikezu T. Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes. Journal of Immunology (Baltimore, Md. : 1950). 181: 3877-86. PMID 18768842  1
2008 Yamamoto M, Ramirez SH, Sato S, Kiyota T, Cerny RL, Kaibuchi K, Persidsky Y, Ikezu T. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. The American Journal of Pathology. 172: 521-33. PMID 18187566 DOI: 10.2353/ajpath.2008.070076  1
2008 Gendelman S, Gendelman HE, Ikezu T. Huntington's disease Neuroimmune Pharmacology. 389-401. DOI: 10.1007/978-0-387-72573-4_28  1
2008 Ikezu T. Alzheimer's disease Neuroimmune Pharmacology. 343-362. DOI: 10.1007/978-0-387-72573-4_25  1
2008 Ikezu T, Gendelman HE. Neurobiology and neural systems Neuroimmune Pharmacology. 171-182. DOI: 10.1007/978-0-387-72573-4_14  1
2008 Gendelman HE, Ikezu T. Introducing neuroimmune pharmacology Neuroimmune Pharmacology. 1-3. DOI: 10.1007/978-0-387-72573-4_1  1
2007 Buescher JL, Gross S, Gendelman HE, Ikezu T. The neuropathogenesis of HIV-1 infection. Handbook of Clinical Neurology. 85: 45-67. PMID 18808975 DOI: 10.1016/S0072-9752(07)85004-4  1
2007 Yamamoto M, Kiyota T, Walsh SM, Ikezu T. Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 2: 213-21. PMID 18040846 DOI: 10.1007/s11481-006-9049-8  1
2007 Gorantla S, Liu J, Sneller H, Dou H, Holguin A, Smith L, Ikezu T, Volsky DJ, Poluektova L, Gendelman HE. Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 179: 4345-56. PMID 17878329  1
2007 Flaherty DP, Walsh SM, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands. Journal of Medicinal Chemistry. 50: 4986-92. PMID 17845017 DOI: 10.1021/jm070085f  1
2007 Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. The American Journal of Pathology. 170: 680-92. PMID 17255335 DOI: 10.2353/ajpath.2007.060378  1
2007 Horiba M, Martinez LB, Buescher JL, Sato S, Limoges J, Jiang Y, Jones C, Ikezu T. OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions. The Journal of General Virology. 88: 236-41. PMID 17170456 DOI: 10.1099/vir.0.82066-0  1
2006 Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. Journal of Neurochemistry. 98: 1573-84. PMID 16923168 DOI: 10.1111/j.1471-4159.2006.04059.x  1
2006 Huang Y, Erdmann N, Peng H, Herek S, Davis JS, Luo X, Ikezu T, Zheng J. TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation. Journal of Immunology (Baltimore, Md. : 1950). 177: 2304-13. PMID 16887991  1
2006 Persidsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber GA, Shimokawa H, Kaibuchi K, Ikezu T. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood. 107: 4770-80. PMID 16478881 DOI: 10.1182/blood-2005-11-4721  1
2005 Yamamoto M, Horiba M, Buescher JL, Huang D, Gendelman HE, Ransohoff RM, Ikezu T. Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. The American Journal of Pathology. 166: 1475-85. PMID 15855647  1
2004 Xiong H, McCabe L, Costello J, Anderson E, Weber G, Ikezu T. Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease. Neurobiology of Aging. 25: 905-11. PMID 15212844 DOI: 10.1016/j.neurobiolaging.2003.09.007  1
2004 Carlson KA, Limoges J, Pohlman GD, Poluektova LY, Langford D, Masliah E, Ikezu T, Gendelman HE. OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. Journal of Neuroimmunology. 150: 186-98. PMID 15081264 DOI: 10.1016/j.jneuroim.2004.01.021  1
2004 Li X, Ikezu T, Hexum TD. Betagamma subunits mediate the NPY enhancement of ATP-stimulated inositol phosphate formation. Peptides. 25: 267-74. PMID 15063008 DOI: 10.1016/j.peptides.2003.12.019  1
2004 Carlson KA, Leisman G, Limoges J, Pohlman GD, Horiba M, Buescher J, Gendelman HE, Ikezu T. Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. Journal of Immunology (Baltimore, Md. : 1950). 172: 381-91. PMID 14688346  1
2003 Ikezu T, Luo X, Weber GA, Zhao J, McCabe L, Buescher JL, Ghorpade A, Zheng J, Xiong H. Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity. Journal of Neurochemistry. 85: 925-34. PMID 12716424  1
2003 Luo X, Weber GA, Zheng J, Gendelman HE, Ikezu T. C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease. Journal of Neuroimmunology. 135: 62-71. PMID 12576225 DOI: 10.1016/S0165-5728(02)00444-7  1
2002 Li X, Drakulich DA, Zhang P, Shen M, Weber GA, Ikezu T, Hexum TD. Transduction of bovine adrenal chromaffin cells using a recombinant adenovirus expressing GFP. Journal of Neuroscience Methods. 122: 91-6. PMID 12535768 DOI: 10.1016/S0165-0270(02)00295-9  1
1999 Parolini I, Sargiacomo M, Galbiati F, Rizzo G, Grignani F, Engelman JA, Okamoto T, Ikezu T, Scherer PE, Mora R, Rodriguez-Boulan E, Peschle C, Lisanti MP. Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex. The Journal of Biological Chemistry. 274: 25718-25. PMID 10464309 DOI: 10.1074/jbc.274.36.25718  1
1999 Ikezu T, Yasuhara S, Granneman JG, Kraemer FB, Okamoto T, Tompkins RG, Martyn JA. A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury. The American Journal of Physiology. 277: E316-24. PMID 10444428  1
1999 Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6538-48. PMID 10414982  1
1998 Ikezu T, Ueda H, Trapp BD, Nishiyama K, Sha JF, Volonte D, Galbiati F, Byrd AL, Bassell G, Serizawa H, Lane WS, Lisanti MP, Okamoto T. Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types. Brain Research. 804: 177-92. PMID 9841091 DOI: 10.1016/S0006-8993(98)00498-3  1
1998 Engelman JA, Chu C, Lin A, Jo H, Ikezu T, Okamoto T, Kohtz DS, Lisanti MP. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. Febs Letters. 428: 205-11. PMID 9654135 DOI: 10.1016/S0014-5793(98)00470-0  1
1998 Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamoto T. Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein. The Journal of Biological Chemistry. 273: 10485-95. PMID 9553108 DOI: 10.1074/jbc.273.17.10485  1
1997 Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA. Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. The Journal of Biological Chemistry. 272: 25289-95. PMID 9312146 DOI: 10.1074/jbc.272.40.25289  1
1997 Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, Nishimoto I. G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. The Embo Journal. 16: 4897-907. PMID 9305632 DOI: 10.1093/emboj/16.16.4897  1
1997 Giambarella U, Murayama Y, Ikezu T, Fujita T, Nishimoto I. Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation Febs Letters. 412: 97-101. PMID 9257698 DOI: 10.1016/S0014-5793(97)00753-9  1
1997 Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. Identification of peptide and protein ligands for the caveolin- scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins Journal of Biological Chemistry. 272: 6525-6533. DOI: 10.1074/jbc.272.10.6525  1
1996 Ikezu T, Okamoto T, Komatsuzaki K, Matsui T, Jeevendra Martyn JA, Nishimoto I. Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP Embo Journal. 15: 2468-2475. PMID 8665854  1
1995 Ikezu T, Okamoto T, Giambarella U, Yokota T, Nishimoto I. In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins: Distinct roles of cytoplasmic domains and signal sequestration by the receptor Journal of Biological Chemistry. 270: 29224-29228. PMID 7493951 DOI: 10.1074/jbc.270.49.29224  1
1994 Ikezu T, Okamoto T, Murayama Y, Homma Y, Ogata E, Nishimoto I. Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of Gαi2 a novel implication of retinoblastoma gene product Journal of Biological Chemistry. 269: 31955-31961. PMID 7989371  1
1993 Takahashi K, Murayama Y, Okamoto T, Yokota T, Ikezu T, Takahashi S, Giambarella U, Ogata E, Nishimoto I. Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with β-adrenergic receptor Proceedings of the National Academy of Sciences of the United States of America. 90: 11772-11776. PMID 8265625  1
1992 Okamoto T, Ikezu T, Murayama Y, Ogata E, Nishimoto I. Measurement of GTPγS binding to specific G proteins in membranes using G-protein antibodies Febs Letters. 305: 125-128. PMID 1618340 DOI: 10.1016/0014-5793(92)80878-K  1
1992 Ikezu T, Okamoto T, Ogata E, Nishimoto I. Amino acids 356-372 constitute a Gi-activator sequence of the α2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif Febs Letters. 311: 29-32. PMID 1327875 DOI: 10.1016/0014-5793(92)81359-T  1
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