Jay P. McLaughlin - Publications

Affiliations: 
Psychology Northeastern University, Boston, MA, United States 
Area:
Experimental Psychology, Psychobiology Psychology

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Norwood VM, Brice-Tutt A, Eans SO, Stacy H, Shi G, Ratnayake R, Rocca JR, Abboud KA, Li C, Luesch H, McLaughlin JP, Huigens Iii RW. Preventing Morphine Seeking Behavior through the Re-engineering of Vincamine's Biological Activity. Journal of Medicinal Chemistry. PMID 31913038 DOI: 10.1021/acs.jmedchem.9b01924  0.44
2019 Cirino TJ, Eans SO, Medina JM, Wilson LL, Mottinelli M, Intagliata S, McCurdy CR, McLaughlin JP. Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain. Frontiers in Pharmacology. 10: 678. PMID 31258480 DOI: 10.3389/fphar.2019.00678  0.44
2019 Harris HM, Eans SO, Ganno ML, Davis JC, Dooley CT, McLaughlin JP, Nefzi A. Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs. Organic & Biomolecular Chemistry. PMID 31094391 DOI: 10.1039/c9ob00882a  0.44
2017 McLaughlin JP, Paris JJ, Mintzopoulos D, Hymel KA, Kim JK, Cirino TJ, Gillis TE, Eans SO, Vitaliano GD, Medina JM, Krapf RC, Stacy HM, Kaufman MJ. Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 2: 599-609. PMID 29057370 DOI: 10.1016/j.bpsc.2017.04.002  1
2017 Shao J, Houghten RA, Dooley CT, Cazares M, McLaughlin JP, Eans SO, Ganno ML, Hoot MR, Giulianotti MA, Yu Y. A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation. Organic & Biomolecular Chemistry. PMID 28875208 DOI: 10.1039/c7ob01924f  0.44
2017 Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP. Selective κ opioid receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. British Journal of Pharmacology. PMID 28494108 DOI: 10.1111/bph.13854  0.44
2016 Váradi A, Marrone GF, Palmer TC, Narayan A, Szabó MR, Le Rouzic V, Grinnell SG, Subrath JJ, Warner E, Kalra S, Hunkele A, Pagirsky J, Eans SO, Medina JM, Xu J, ... ... McLaughlin JP, et al. Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism which do not recruit β-arrestin-2. Journal of Medicinal Chemistry. PMID 27556704 DOI: 10.1021/acs.jmedchem.6b00748  1
2015 Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Direct High Throughput In Vivo Screening: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine bis-Piperazines. Acs Combinatorial Science. PMID 26651386 DOI: 10.1021/acscombsci.5b00126  1
2015 Mediouni S, Garibaldi Marcondes MC, Miller C, McLaughlin JP, Valente ST. The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. Frontiers in Microbiology. 6: 1164. PMID 26557111 DOI: 10.3389/fmicb.2015.01164  1
2015 Váradi A, Marrone GF, Eans SO, Ganno ML, Subrath JJ, Le Rouzic V, Hunkele A, Pasternak GW, McLaughlin JP, Majumdar S. Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior. Acs Chemical Neuroscience. PMID 26325040 DOI: 10.1021/acschemneuro.5b00153  1
2015 Paris JJ, Singh HD, Carey AN, McLaughlin JP. Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice. Behavioural Brain Research. 291: 209-18. PMID 26005128 DOI: 10.1016/j.bbr.2015.05.021  1
2015 Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A. Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors. Journal of Medicinal Chemistry. 58: 4905-17. PMID 25996309 DOI: 10.1021/jm501637c  1
2015 McLaughlin JP, Paris JJ. Contribution of HIV-Tat protein to HIV-sequelae. Current Hiv Research. 13: 2. PMID 25817718  1
2015 Carey AN, Liu X, Mintzopoulos D, Paris JJ, McLaughlin JP, Kaufman MJ. Conditional Tat protein brain expression in the GT-tg bigenic mouse induces cerebral fractional anisotropy abnormalities. Current Hiv Research. 13: 3-9. PMID 25619988  1
2015 Mediouni S, Jablonski J, Paris JJ, Clementz MA, Thenin-Houssier S, McLaughlin JP, Valente ST. Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice. Current Hiv Research. 13: 64-79. PMID 25613133  1
2015 Hu M, Giulianotti MA, McLaughlin JP, Shao J, Debevec G, Maida LE, Geer P, Cazares M, Misler J, Li L, Dooley C, Ganno ML, Eans SO, Mizrachi E, Santos RG, et al. Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities. European Journal of Medicinal Chemistry. 92: 270-81. PMID 25559207 DOI: 10.1016/j.ejmech.2014.12.049  1
2014 McLaughlin JP, Paris JJ. Contribution of HIV-Tat protein to HIV-sequelae (part 1). Current Hiv Research. 12: 377. PMID 25781162  1
2014 McLaughlin JP, Ganno ML, Eans SO, Mizrachi E, Paris JJ. HIV-1 Tat protein exposure potentiates ethanol reward and reinstates extinguished ethanol-conditioned place preference. Current Hiv Research. 12: 415-23. PMID 25760047  1
2014 Paris JJ, Fenwick J, McLaughlin JP. Estrous cycle and HIV-1 Tat protein influence cocaine-conditioned place preference and induced locomotion of female mice. Current Hiv Research. 12: 388-96. PMID 25613137  1
2014 Journigan VB, Mésangeau C, Vyas N, Eans SO, Cutler SJ, McLaughlin JP, Mollereau C, McCurdy CR. Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors. Journal of Medicinal Chemistry. 57: 8903-27. PMID 25268943 DOI: 10.1021/jm500989n  1
2014 Hymel KA, Eans SO, L Sitchenko K, Gomes SM, Lukowsky AL, Medina JM, Sypek EI, Carey AN, McLaughlin JP. Stress-induced increases in depression-like and cocaine place-conditioned behaviors are reversed by disruption of memories during reconsolidation. Behavioural Pharmacology. 25: 599-608. PMID 25083575 DOI: 10.1097/FBP.0000000000000074  1
2014 Paris JJ, Fenwick J, McLaughlin JP. Progesterone protects normative anxiety-like responding among ovariectomized female mice that conditionally express the HIV-1 regulatory protein, Tat, in the CNS. Hormones and Behavior. 65: 445-53. PMID 24726788 DOI: 10.1016/j.yhbeh.2014.04.001  1
2014 Aldrich JV, Senadheera SN, Ross NC, Reilley KA, Ganno ML, Eans SE, Murray TF, McLaughlin JP. Alanine analogues of [D-Trp]CJ-15,208: novel opioid activity profiles and prevention of drug- and stress-induced reinstatement of cocaine-seeking behaviour. British Journal of Pharmacology. 171: 3212-22. PMID 24588614 DOI: 10.1111/bph.12664  1
2014 Paris JJ, Singh HD, Ganno ML, Jackson P, McLaughlin JP. Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat. Psychopharmacology. 231: 2349-60. PMID 24352568 DOI: 10.1007/s00213-013-3385-1  1
2014 Paris JJ, Carey AN, Shay CF, Gomes SM, He JJ, McLaughlin JP. Effects of conditional central expression of HIV-1 tat protein to potentiate cocaine-mediated psychostimulation and reward among male mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 380-8. PMID 23945478 DOI: 10.1038/npp.2013.201  1
2013 Eans SO, Ganno ML, Reilley KJ, Patkar KA, Senadheera SN, Aldrich JV, McLaughlin JP. The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration. British Journal of Pharmacology. 169: 426-36. PMID 23425081 DOI: 10.1111/bph.12132  1
2013 Paris JJ, Eans SO, Mizrachi E, Reilley KJ, Ganno ML, McLaughlin JP. Central administration of angiotensin IV rapidly enhances novel object recognition among mice. Neuropharmacology. 70: 247-53. PMID 23416700 DOI: 10.1016/j.neuropharm.2013.01.025  1
2013 Armishaw CJ, Banerjee J, Ganno ML, Reilley KJ, Eans SO, Mizrachi E, Gyanda R, Hoot MR, Houghten RA, McLaughlin JP. Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library. Acs Combinatorial Science. 15: 153-61. PMID 23414173 DOI: 10.1021/co300152x  1
2013 Hoot MR, Sypek EI, Reilley KJ, Carey AN, Bidlack JM, McLaughlin JP. Inhibition of Gβγ-subunit signaling potentiates morphine-induced antinociception but not respiratory depression, constipation, locomotion, and reward. Behavioural Pharmacology. 24: 144-52. PMID 23412114 DOI: 10.1097/FBP.0b013e32835f3d2f  1
2013 Aldrich JV, Senadheera SN, Ross NC, Ganno ML, Eans SO, McLaughlin JP. The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior. Journal of Natural Products. 76: 433-8. PMID 23327691 DOI: 10.1021/np300697k  1
2013 Carey AN, Liu X, Mintzopoulos D, Paris JJ, Muschamp JW, McLaughlin JP, Kaufman MJ. Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 43: 49-54. PMID 23269344 DOI: 10.1016/j.pnpbp.2012.12.018  1
2013 Jackson KJ, McLaughlin JP, Carroll FI, Damaj MI. Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice. Psychopharmacology. 226: 763-8. PMID 22526543 DOI: 10.1007/s00213-012-2716-y  1
2012 Aldrich JV, McLaughlin JP. Opioid Peptides: Potential for Drug Development. Drug Discovery Today. Technologies. 9: e23-e31. PMID 23316256 DOI: 10.1016/j.ddtec.2011.07.007  1
2012 Walker BM, Valdez GR, McLaughlin JP, Bakalkin G. Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence. Alcohol (Fayetteville, N.Y.). 46: 359-70. PMID 22459870 DOI: 10.1016/j.alcohol.2011.10.006  1
2012 Carey AN, Sypek EI, Singh HD, Kaufman MJ, McLaughlin JP. Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse. Behavioural Brain Research. 229: 48-56. PMID 22197678 DOI: 10.1016/j.bbr.2011.12.019  1
2012 Toll L, Khroyan TV, Sonmez K, Ozawa A, Lindberg I, McLaughlin JP, Eans SO, Shahien AA, Kapusta DR. Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 947-54. PMID 22038051 DOI: 10.1096/fj.11-192831  1
2012 Ross NC, Reilley KJ, Murray TF, Aldrich JV, McLaughlin JP. Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting κ opioid receptor antagonism. British Journal of Pharmacology. 165: 1097-108. PMID 21671905 DOI: 10.1111/j.1476-5381.2011.01544.x  1
2011 Paris JJ, Reilley KJ, McLaughlin JP. Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment. Journal of Addiction Research & Therapy. PMID 22900234 DOI: 10.4172/2155-6105.S4-007  1
2011 Grimwood S, Lu Y, Schmidt AW, Vanase-Frawley MA, Sawant-Basak A, Miller E, McLean S, Freeman J, Wong S, McLaughlin JP, Verhoest PR. Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 339: 555-66. PMID 21821697 DOI: 10.1124/jpet.111.185108  1
2011 Aldrich JV, Kulkarni SS, Senadheera SN, Ross NC, Reilley KJ, Eans SO, Ganno ML, Murray TF, McLaughlin JP. Unexpected opioid activity profiles of analogues of the novel peptide kappa opioid receptor ligand CJ-15,208. Chemmedchem. 6: 1739-45. PMID 21761566 DOI: 10.1002/cmdc.201100113  1
2010 Ross NC, Kulkarni SS, McLaughlin JP, Aldrich JV. Synthesis of CJ-15,208, a novel κ-opioid receptor antagonist. Tetrahedron Letters. 51: 5020-5023. PMID 22865937 DOI: 10.1016/j.tetlet.2010.07.086  1
2010 Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library. The Aaps Journal. 12: 318-29. PMID 20422341 DOI: 10.1208/s12248-010-9191-3  1
2010 Sperling RE, Gomes SM, Sypek EI, Carey AN, McLaughlin JP. Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration. Psychopharmacology. 210: 199-209. PMID 20401606 DOI: 10.1007/s00213-010-1844-5  1
2009 McLaughlin JP, Gomes S, Seliga A, Goyette SR, Morrison A, Reich CG, Frye CA. Northeast Under/graduate Research Organization for Neuroscience (NEURON): Our Thirteenth Conference for Neuroscience Trainees and Educators. Journal of Undergraduate Neuroscience Education : June : a Publication of Fun, Faculty For Undergraduate Neuroscience. 7: A65-8. PMID 23493230  1
2009 Aldrich JV, Patkar KA, McLaughlin JP. Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action. Proceedings of the National Academy of Sciences of the United States of America. 106: 18396-401. PMID 19841255 DOI: 10.1073/pnas.0910180106  1
2009 McLaughlin JP, Gomes S, Seliga A, Ramos-Goyette S, Morrison A, Reich CG, Frye CA. Northeast Under/graduate Research Organization for Neuroscience (NEURON): our 13th conference for neuroscience trainees and educators. Cbe Life Sciences Education. 8: 111-3. PMID 19487498 DOI: 10.1187/cbe.08-08-0050  1
2009 Aldrich JV, McLaughlin JP. Peptide kappa opioid receptor ligands: potential for drug development. The Aaps Journal. 11: 312-22. PMID 19430912 DOI: 10.1208/s12248-009-9105-4  1
2009 Kulkarni SS, Ross NC, McLaughlin JP, Aldrich JV. Synthesis of cyclic tetrapeptide CJ 15,208: a novel kappa opioid receptor antagonist. Advances in Experimental Medicine and Biology. 611: 269-70. PMID 19400188 DOI: 10.1007/978-0-387-73657-0_121  1
2009 Carey AN, Lyons AM, Shay CF, Dunton O, McLaughlin JP. Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4293-300. PMID 19339623 DOI: 10.1523/JNEUROSCI.6146-08.2009  1
2008 Reindl JD, Rowan K, Carey AN, Peng X, Neumeyer JL, McLaughlin JP. Antidepressant-like effects of the novel kappa opioid antagonist MCL-144B in the forced-swim test. Pharmacology. 81: 229-35. PMID 18176093 DOI: 10.1159/000112867  1
2007 Carey AN, Borozny K, Aldrich JV, McLaughlin JP. Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn. European Journal of Pharmacology. 569: 84-9. PMID 17568579 DOI: 10.1016/j.ejphar.2007.05.007  1
2006 McLaughlin JP, Land BB, Li S, Pintar JE, Chavkin C. Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 787-94. PMID 16123754 DOI: 10.1038/sj.npp.1300860  1
2006 McLaughlin JP, Li S, Valdez J, Chavkin TA, Chavkin C. Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1241-8. PMID 16123746 DOI: 10.1038/sj.npp.1300872  1
2004 Xu M, Petraschka M, McLaughlin JP, Westenbroek RE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Terman GW, Chavkin C. Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4576-84. PMID 15140929 DOI: 10.1523/JNEUROSCI.5552-03.2004  1
2004 McLaughlin JP, Myers LC, Zarek PE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Chavkin C. Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. The Journal of Biological Chemistry. 279: 1810-8. PMID 14597630 DOI: 10.1074/jbc.M305796200  1
2003 McLaughlin JP, Marton-Popovici M, Chavkin C. Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5674-83. PMID 12843270  1
2003 McLaughlin JP, Xu M, Mackie K, Chavkin C. Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. The Journal of Biological Chemistry. 278: 34631-40. PMID 12815037 DOI: 10.1074/jbc.M304022200  1
2002 Bidlack JM, Cohen DJ, McLaughlin JP, Lou R, Ye Y, Wentland MP. 8-Carboxamidocyclazocine: A long-acting, novel benzomorphan Journal of Pharmacology and Experimental Therapeutics. 302: 374-380. PMID 12065740 DOI: 10.1124/jpet.302.1.374  1
2001 Chavkin C, McLaughlin JP, Celver JP. Regulation of opioid receptor function by chronic agonist exposure: constitutive activity and desensitization. Molecular Pharmacology. 60: 20-5. PMID 11408596  1
2001 McLaughlin JP, Chavkin C. Tyrosine phosphorylation of the mu-opioid receptor regulates agonist intrinsic efficacy. Molecular Pharmacology. 59: 1360-8. PMID 11353794  1
2000 Appleyard SM, McLaughlin JP, Chavkin C. Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy. The Journal of Biological Chemistry. 275: 38281-5. PMID 10995763 DOI: 10.1074/jbc.M006756200  1
2000 Bidlack JM, McLaughlin JP, Wentland MP. Partial opioids. Medications for the treatment of pain and drug abuse Annals of the New York Academy of Sciences. 909: 1-11. PMID 10911920  1
1999 Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D. Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. Proceedings of the National Academy of Sciences of the United States of America. 96: 10385-90. PMID 10468617 DOI: 10.1073/pnas.96.18.10385  1
1999 McLaughlin JP, Hill KP, Jiang Q, Sebastian A, Archer S, Bidlack JM. Nitrocinnamoyl and chlorocinnamoyl derivatives of dihydrocodeinone: In vivo and in vitro characterization of μ-selective agonist and antagonist activity Journal of Pharmacology and Experimental Therapeutics. 289: 304-311. PMID 10087018  1
1997 McLaughlin JP, Sebastian A, Archer S, Bidlack JM. 14β-Chlorocinnamoylamino derivatives of metopon: Long-term μ-opioid receptor antagonists European Journal of Pharmacology. 320: 121-129. PMID 9059844 DOI: 10.1016/S0014-2999(96)00904-1  1
1995 McLaughlin JP, Nowak D, Sebastian A, Schultz AG, Archer S, Bidlack JM. Metopon and two unique derivatives: affinity and selectivity for the multiple opioid receptors. European Journal of Pharmacology. 294: 201-6. PMID 8788432 DOI: 10.1016/0014-2999(95)00536-6  1
1994 McLaughlin JP, Sebastian A, Archer S, Bidlack JM. 14β-Chlorocinnamoylamino derivatives of metopon interact differentially with the mu opioid receptor Regulatory Peptides. 54: 187-188. DOI: 10.1016/0167-0115(94)90453-7  1
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