William J. Bowers, Ph.D. - Publications

Affiliations: 
Neurology, Center for Neural Development and Disease University of Rochester Medical Center, Rochester, NY, United States 
Area:
CNS Gene Therapy, Immunotherapy, Neuroinflammation, Alzheimer's Disease

110 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Southwell AL, Franciosi S, Villanueva EB, Xie Y, Winter LA, Veeraraghavan J, Jonason A, Felczak B, Zhang W, Kovalik V, Waltl S, Hall G, Pouladi MA, Smith ES, Bowers WJ, et al. Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease. Neurobiology of Disease. 76: 46-56. PMID 25662335 DOI: 10.1016/J.Nbd.2015.01.002  0.337
2015 Evans EE, Jonason AS, Bussler H, Torno S, Veeraraghavan J, Reilly C, Doherty MA, Seils J, Winter LA, Mallow C, Kirk R, Howell A, Giralico S, Scrivens M, Klimatcheva K, ... ... Bowers WJ, et al. Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies. Cancer Immunology Research. 3: 689-701. PMID 25614511 DOI: 10.1158/2326-6066.Cir-14-0171  0.316
2015 Evans EE, Fisher TL, Edington C, Bussler H, Torno S, Jonason AS, Veeraraghavan J, Reilly C, Doherty MA, Seils J, Winter LA, Pandina T, Mallow C, Kirk R, Howell A, ... ... Bowers WJ, et al. Abstract A67: Phase 1 study of VX15/2503, an immunomodulatory antibody to Semaphorin 4D that reverses tumor growth in preclinical studies Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-A67  0.3
2014 Smith ES, Jonason A, Reilly C, Veeraraghavan J, Fisher T, Doherty M, Klimatcheva E, Mallow C, Cornelius C, Leonard JE, Marchi N, Janigro D, Argaw AT, Pham T, Seils J, ... ... Bowers WJ, et al. SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease. Neurobiology of Disease. 73: 254-268. PMID 25461192 DOI: 10.1016/J.Nbd.2014.10.008  0.328
2014 Evans EE, Bussler H, Torno S, Veeraraghavan J, Jonason AS, Doherty MA, Reilly C, Mallow C, Seils J, Paris M, Fisher TL, Bowers WJ, Scrivens M, Balch L, Kirk R, et al. Abstract 5030: Antibody blockade of Semaphorin 4D promotes tumor rejection and improves response to immune checkpoint blockade and chemotherapy Cancer Research. 74: 5030-5030. DOI: 10.1158/1538-7445.Am2014-5030  0.305
2013 Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ. Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies. The American Journal of Pathology. 182: 2285-97. PMID 23567638 DOI: 10.1016/J.Ajpath.2013.02.030  0.638
2012 Montgomery SL, Bowers WJ. Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 42-59. PMID 21728035 DOI: 10.1007/S11481-011-9287-2  0.616
2011 Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. Plos One. 6: e27728. PMID 22132130 DOI: 10.1371/Journal.Pone.0027728  0.523
2011 Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL. Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. The European Journal of Neuroscience. 34: 1256-67. PMID 21995852 DOI: 10.1111/J.1460-9568.2011.07862.X  0.493
2011 Hunter JM, Bowers WJ, Maarouf CL, Mastrangelo MA, Daugs ID, Kokjohn TA, Kalback WM, Luehrs DC, Valla J, Beach TG, Roher AE. Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 27: 361-76. PMID 21860086 DOI: 10.3233/Jad-2011-110608  0.329
2011 Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Knowlden SA, Wright TW, Bowers WJ. Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain. The American Journal of Pathology. 179: 2053-70. PMID 21835156 DOI: 10.1016/J.Ajpath.2011.07.001  0.636
2011 Domm W, Brooks L, Chung HL, Feng C, Bowers WJ, Watson G, McGrath JL, Dewhurst S. Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier. Vaccine. 29: 7080-9. PMID 21801777 DOI: 10.1016/J.Vaccine.2011.07.008  0.363
2011 de Silva S, Bowers WJ. Targeting the central nervous system with herpes simplex virus / Sleeping Beauty hybrid amplicon vectors. Current Gene Therapy. 11: 332-40. PMID 21711226 DOI: 10.2174/156652311797415845  0.533
2011 Desai MK, Guercio BJ, Narrow WC, Bowers WJ. An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction. Glia. 59: 627-40. PMID 21294162 DOI: 10.1002/Glia.21131  0.679
2011 Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proceedings of the National Academy of Sciences of the United States of America. 108: 852-7. PMID 21187387 DOI: 10.1073/Pnas.1015981108  0.499
2010 Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1471-1481. PMID 28178507 DOI: 10.1038/mt.2010.111  0.666
2010 Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nature Medicine. 16: 998-1000. PMID 20729864 DOI: 10.1038/Nm.2199  0.488
2010 Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ. Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target. The American Journal of Pathology. 177: 1422-35. PMID 20696774 DOI: 10.2353/Ajpath.2010.100087  0.74
2010 Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9567-77. PMID 20631185 DOI: 10.1523/Jneurosci.0942-10.2010  0.623
2010 de Silva S, Lotta LT, Burris CA, Bowers WJ. Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform. Human Gene Therapy. 21: 1615-22. PMID 20568967 DOI: 10.1089/Hum.2010.022  0.533
2010 Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1471-81. PMID 20551911 DOI: 10.1038/Mt.2010.111  0.689
2010 de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Izsvák Z, Ivics Z, Bowers WJ. Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo. Human Gene Therapy. 21: 1603-13. PMID 20507234 DOI: 10.1089/Hum.2010.062  0.533
2010 Ryan DA, Narrow WC, Federoff HJ, Bowers WJ. An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. Journal of Neuroscience Methods. 190: 171-9. PMID 20452375 DOI: 10.1016/J.Jneumeth.2010.05.001  0.666
2010 Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. GTPase activity plays a key role in the pathobiology of LRRK2. Plos Genetics. 6: e1000902. PMID 20386743 DOI: 10.1371/Journal.Pgen.1000902  0.319
2010 Park KM, Bowers WJ. Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cellular Signalling. 22: 977-83. PMID 20096353 DOI: 10.1016/J.Cellsig.2010.01.010  0.505
2010 Park KM, Yule DI, Bowers WJ. Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons. Cellular Signalling. 22: 519-26. PMID 19922794 DOI: 10.1016/J.Cellsig.2009.11.006  0.526
2010 de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Federoff HJ, Bowers WJ. Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform. Gene Therapy. 17: 424-31. PMID 19865178 DOI: 10.1038/Gt.2009.144  0.683
2010 Bowers WJ, Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC. P2-242: Oligodendrocyte cell lineage represents an amyloid beta 1-42 sensitive cell population leading to white matter alterations during early Alzheimer's disease Alzheimer's & Dementia. 6: S385-S385. DOI: 10.1016/J.Jalz.2010.05.1291  0.74
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-2040. PMID 28178451 DOI: 10.1038/mt.2009.174  0.499
2009 de Silva S, Bowers WJ. Herpes Virus Amplicon Vectors. Viruses. 1: 594-629. PMID 19956558 DOI: 10.3390/V1030594  0.533
2009 Park KM, Yule DI, Bowers WJ. Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter. The Journal of Biological Chemistry. 284: 27557-66. PMID 19666470 DOI: 10.1074/Jbc.M109.034504  0.487
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-40. PMID 19638957 DOI: 10.1038/Mt.2009.174  0.54
2009 Chiu YG, Bowers WJ, Lim ST, Ryan DA, Federoff HJ. Effects of herpes simplex virus amplicon transduction on murine dendritic cells. Human Gene Therapy. 20: 442-52. PMID 19199821 DOI: 10.1089/Hum.2008.160  0.684
2009 Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain Neuroimage. 47: T27-T35. PMID 19095069 DOI: 10.1016/J.Neuroimage.2008.11.012  0.506
2009 Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ, Tolba K. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 113: 3264-75. PMID 18952891 DOI: 10.1182/Blood-2008-07-168203  0.527
2009 Desai MK, Sudol KL, Janelsins MC, Mastrangelo MA, Frazer ME, Bowers WJ. Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia. 57: 54-65. PMID 18661556 DOI: 10.1002/Glia.20734  0.735
2009 Federoff HJ, Chiu YG, Bowers WJ, Lim ST, Ryan DA. Effects of HSV amplicon transduction on murine dendritic cells Human Gene Therapy. 90126111624022. DOI: 10.1089/Hgt.2008.160  0.663
2008 Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 845-853. PMID 28178487 DOI: 10.1038/Mt.2008.39  0.568
2008 Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. The American Journal of Pathology. 173: 1768-82. PMID 18974297 DOI: 10.2353/Ajpath.2008.080528  0.723
2008 Park KM, Yule DI, Bowers WJ. Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor. The Journal of Biological Chemistry. 283: 33069-79. PMID 18838384 DOI: 10.1074/Jbc.M802209200  0.505
2008 Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 845-53. PMID 18388924 DOI: 10.1038/mt.2008.39  0.509
2008 Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff HJ, Bowers WJ. Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. The Journal of Gene Medicine. 10: 152-64. PMID 18058952 DOI: 10.1002/Jgm.1130  0.698
2008 Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunology, Immunotherapy : Cii. 57: 663-75. PMID 17952436 DOI: 10.1007/S00262-007-0405-1  0.523
2008 Desai MK, Sudol KL, Janelsins MC, Mastrangelo MA, Frazer ME, Bowers WJ. P3-404: Triple-transgenic Alzheimer's disease mice exhibit marked abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology Alzheimer's & Dementia. 4: T640-T640. DOI: 10.1016/J.Jalz.2008.05.1975  0.735
2008 Bowers WJ, Janelsins MC, Federoff HJ. Gene therapy and vaccination Neuroimmune Pharmacology. 709-724. DOI: 10.1007/978-0-387-72573-4_48  0.605
2007 Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD. Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Research. 67: 10027-37. PMID 17942937 DOI: 10.1158/0008-5472.Can-06-2391  0.535
2007 Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S. HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine. 25: 7410-21. PMID 17868958 DOI: 10.1016/J.Vaccine.2007.08.015  0.534
2007 Peterson EB, Mastrangelo MA, Federoff HJ, Bowers WJ. Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1848-55. PMID 17653102 DOI: 10.1038/Sj.Mt.6300267  0.579
2007 Santos K, Sanfilippo CM, Narrow WC, Casey AE, Rodriguez-Colon SM, McDermott MP, Federoff HJ, Bowers WJ, Dewhurst S. Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. Journal of Virological Methods. 145: 37-46. PMID 17606303 DOI: 10.1016/J.Jviromet.2007.05.013  0.531
2007 Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S, Frelinger JG. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Human Gene Therapy. 18: 93-105. PMID 17298238 DOI: 10.1089/Hum.2006.082  0.595
2007 Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff HJ, Collier TJ. Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival. Brain Research. 1134: 33-44. PMID 17196186 DOI: 10.1016/J.Brainres.2006.11.079  0.572
2007 Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S. Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. 25: 1634-46. PMID 17145123 DOI: 10.1016/J.Vaccine.2006.11.004  0.568
2007 Tan Y, Rosenblatt JD, Federoff HJ, Bowers WJ, Tolba KA. Regulation of TLR Signaling by USP7. Blood. 110: 2300-2300. DOI: 10.1182/Blood.V110.11.2300.2300  0.534
2006 Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. The Journal of Gene Medicine. 8: 1320-8. PMID 16989006 DOI: 10.1002/Jgm.972  0.741
2006 Tyler CM, Wuertzer CA, Bowers WJ, Federoff HJ. HSV amplicons: neuro applications. Current Gene Therapy. 6: 337-50. PMID 16787185 DOI: 10.2174/156652306777592045  0.774
2006 Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff HJ. Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 580-8. PMID 16412694 DOI: 10.1016/J.Ymthe.2005.11.011  0.585
2006 Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff HJ, Mendell LM. Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Experimental Neurology. 197: 347-52. PMID 16289170 DOI: 10.1016/J.Expneurol.2005.10.008  0.485
2006 Tolba KA, Bowers W, Tan Y, Daubeuf S, Federoff HJ, Rosenblatt JD. HSV ICP0 Inhibits TLR-Mediated NF-κB Response to TLR Signaling. Blood. 108: 5487-5487. DOI: 10.1182/blood.v108.11.5487.5487  0.463
2006 Janelsins MC, Mastrangelo MA, Park KM, Fowlkes KL, Kinsky M, Narrow WC, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. 248. Revealing the Role(s) of TNF-alpha in Early Alzheimer's Disease Via rAAV-Mediated Hippocampal Gene Transfer in a Triple Transgenic Mouse Model Molecular Therapy. 13: S95. DOI: 10.1016/J.Ymthe.2006.08.275  0.684
2006 Fowlkes KL, Mastrangelo MA, Narrow WC, Levites Y, Golde TE, Federoff HJ, Bowers WJ. 247. Devising Aβ-Specific Passive Immunization Strategies for Alzheimer's Disease Using rAAV Vector-Mediated scFv Antibody Delivery Molecular Therapy. 13: S94-S95. DOI: 10.1016/J.Ymthe.2006.08.274  0.548
2005 Federoff HJ, Bowers WJ. Immune shaping and the development of Alzheimer's disease vaccines. Science of Aging Knowledge Environment : Sage Ke. 2005: pe35. PMID 16293586 DOI: 10.1126/Sageke.2005.46.Pe35  0.537
2005 Reinblatt M, Pin RH, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Annals of Surgical Oncology. 12: 1025-36. PMID 16244806 DOI: 10.1245/Aso.2005.03.081  0.52
2005 Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. Journal of Neuroinflammation. 2: 23. PMID 16232318 DOI: 10.1186/1742-2094-2-23  0.671
2005 Corso TD, Torres G, Goulah C, Roy I, Gambino AS, Nayda J, Buckley T, Stachowiak EK, Bergey EJ, Pudavar H, Dutta P, Bloom DC, Bowers WJ, Stachowiak MK. Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Brain Research. Molecular Brain Research. 139: 361-6. PMID 16039006 DOI: 10.1016/J.Molbrainres.2005.05.032  0.309
2005 Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L. Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. Journal of Virology. 79: 2124-32. PMID 15681415 DOI: 10.1128/Jvi.79.4.2124-2132.2005  0.533
2005 Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff HJ. HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiology of Aging. 26: 393-407. PMID 15653168 DOI: 10.1016/J.Neurobiolaging.2004.04.006  0.559
2005 Daubeuf S, Rosenblatt JD, Bowers WJ, Federoff HJ, Tolba KA. HSV Encoded ICP-0 Inhibits TLR Signaling in CLL Cells by Targeting TRAF-6. Blood. 106: 2953-2953. DOI: 10.1182/Blood.V106.11.2953.2953  0.564
2005 Bowers WJ, Mastrangelo MA, Casey AE, Southerland HA, Maguire-Zeiss KA, Federoff HJ. 431. In Utero CNS Delivery of an Integrating HSV-1 Amplicon Vector Leads to Prolonged, Neuron-Specific Gene Expression Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.433  0.578
2004 Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10963-73. PMID 15574746 DOI: 10.1523/Jneurosci.3461-04.2004  0.493
2004 Pin RH, Reinblatt M, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 8: 812-22; discussion 8. PMID 15531234 DOI: 10.1016/J.Gassur.2004.08.007  0.531
2004 Arvanian VL, Bowers WJ, Petruska JC, Motin V, Manuzon H, Narrow WC, Federoff HJ, Mendell LM. Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. Journal of Neurophysiology. 92: 2394-404. PMID 15152019 DOI: 10.1152/Jn.00278.2004  0.508
2004 Daubeuf S, Rosenblatt JD, Bowers WJ, Urbistondo NT, Federoff HJ, Tolba KA. HSV Amplicon Transduction Activates an Innate Immune Response in CLL B Cells;Implications for Immune Therapy and Vaccine Development. Blood. 104: 2514-2514. DOI: 10.1182/Blood.V104.11.2514.2514  0.564
2004 Bowers WJ, Mastrangelo MA, Stanley HA, Chiu Y, Federoff HJ. P4-340 Immunological assessment of acute CNS inflammatory processes elicited in an Alzheimer's disease mouse model following HSV amplicon-based Aβ vaccination Neurobiology of Aging. 25: S572. DOI: 10.1016/S0197-4580(04)81898-0  0.528
2004 Callahan LM, Edwards K, Maguire-Zeiss KA, Bowers WJ, Narrow WC, Kang S, Mastrangelo MA, Giuliano RE, Federoff HJ. P3-259 Expression of pathogenic tau, P301L, leads to microtubule disruption in hippocampal neurons Neurobiology of Aging. 25: S428. DOI: 10.1016/S0197-4580(04)81409-X  0.508
2004 Janelsins MC, Mastrangelo MA, Federoff HJ, Bowers WJ. 226. Developing a CNS-Specific Inflammatory Model To Investigate Gene Therapy/Inflammation Interactions in the Context of Neurodegeneration|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.170  0.697
2004 Stanley HA, Bowers WJ, Mastrangelo MA, Federoff HJ. 211. Creation of a HSV VP22-Sleeping Beauty Fusion Protein To Facilitate Integration of HSV-1 Amplicon Vectors|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.152  0.565
2004 Bowers WJ, Mastrangelo MA, Stanley HA, Chiu Y, Federoff HJ. 43. Immunological Response Characterization in an Alzheimer's Disease Mouse Model Following HSV Amplicon-Based A|[beta]| Vaccination|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.05.068  0.562
2003 Kyrkanides S, Miller Jn, Bowers WJ, Federoff HJ. Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 790-5. PMID 14599812 DOI: 10.1016/J.Ymthe.2003.07.005  0.534
2003 Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff HJ. HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury. Experimental Neurology. 183: 47-55. PMID 12957487 DOI: 10.1016/S0014-4886(03)00080-3  0.675
2003 Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7385-94. PMID 12917374 DOI: 10.1523/Jneurosci.23-19-07385.2003  0.477
2003 Bowers WJ, Olschowka JA, Federoff HJ. Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy. Gene Therapy. 10: 941-5. PMID 12756414 DOI: 10.1038/Sj.Gt.3302047  0.587
2003 Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 21: 2288-97. PMID 12744859 DOI: 10.1016/S0264-410X(03)00099-9  0.532
2003 Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 218-27. PMID 12597910 DOI: 10.1016/S1525-0016(02)00036-9  0.596
2003 Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nature Medicine. 9: 231-5. PMID 12539041 DOI: 10.1038/Nm821  0.554
2002 Wang SW, Mu X, Bowers WJ, Klein WH. Retinal ganglion cell differentiation in cultured mouse retinal explants. Methods (San Diego, Calif.). 28: 448-56. PMID 12507463 DOI: 10.1016/S1046-2023(02)00264-5  0.34
2002 Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. Cancer Research. 62: 6545-51. PMID 12438249  0.493
2002 Maguire-Zeiss KA, Bowers WJ, Federoff HJ. Somatic mosaic approaches and the aging brain. Neurobiology of Aging. 23: 977-84. PMID 12392799 DOI: 10.1016/S0197-4580(02)00077-5  0.53
2002 Bowers WJ, Federoff HJ. Amyloid immunotherapy-engendered CNS inflammation. Neurobiology of Aging. 23: 675-6; discussion 68. PMID 12392770 DOI: 10.1016/S0197-4580(02)00035-0  0.512
2002 Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff HJ, Rosenblatt JD. HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 455-63. PMID 12377186 DOI: 10.1006/Mthe.2002.0693  0.545
2002 Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (New York, N.Y.). 297: 259-63. PMID 12114629 DOI: 10.1126/Science.1072221  0.492
2002 Bowers WJ, Chen X, Guo H, Frisina DR, Federoff HJ, Frisina RD. Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 12-8. PMID 12095298 DOI: 10.1006/Mthe.2002.0627  0.569
2002 Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. Reporter gene transfer induces apoptosis in primary cortical neurons. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 723-30. PMID 12027556 DOI: 10.1006/Mthe.2002.0609  0.731
2002 Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S. Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. Journal of Virology. 76: 5565-80. PMID 11991985 DOI: 10.1128/Jvi.76.11.5565-5580.2002  0.556
2002 Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff HJ, Bowers WJ. Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 300-6. PMID 11863420 DOI: 10.1006/Mthe.2002.0539  0.519
2002 Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development (Cambridge, England). 129: 467-77. PMID 11807038  0.432
2001 Maguire-Zeiss KA, Bowers WJ, Federoff HJ. HSV vector-mediated gene delivery to the central nervous system. Current Opinion in Molecular Therapeutics. 3: 482-90. PMID 11699893  0.527
2001 Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff HJ, Lord EM, Frelinger JG. Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice. Human Gene Therapy. 12: 1867-79. PMID 11589829 DOI: 10.1089/104303401753153929  0.559
2001 Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G. Regulation of neuronal traits by a novel transcriptional complex. Neuron. 31: 353-65. PMID 11516394 DOI: 10.1016/S0896-6273(01)00371-3  0.525
2001 Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 98: 287-95. PMID 11435295 DOI: 10.1182/Blood.V98.2.287  0.734
2001 Chen X, Frisina RD, Bowers WJ, Frisina DR, Federoff HJ. HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 958-63. PMID 11407910 DOI: 10.1006/Mthe.2001.0334  0.583
2001 Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Therapy. 8: 111-20. PMID 11313780 DOI: 10.1038/Sj.Gt.3301340  0.736
2001 Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 410: 89-93. PMID 11242047 DOI: 10.1038/35065091  0.479
2001 Bowers WJ, Maguire-Zeiss KA, Harvey BK, Federoff HJ. Gene therapeutic approaches to the treatment of Parkinson's disease Clinical Neuroscience Research. 1: 483-495. DOI: 10.1016/S1566-2772(01)00026-3  0.675
2000 Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff HJ. Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. Human Gene Therapy. 11: 2341-52. PMID 11096439 DOI: 10.1089/104303400750038453  0.499
2000 Bowers WJ, Howard DF, Federoff HJ. Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 294-9. PMID 10933945 DOI: 10.1006/Mthe.2000.0039  0.58
1999 Tolba K, Federoff HJ, Bowers W, Facciponte J, Baka J, Challita-Eid P, Rosenblatt JD. Helper-Free Herpes Simplex Virus Amplicons allow Efficient Transduction of Leukemia Cells with a costimulatory ligand without Loss of MHC-I Expression Journla of Immunotherapy. 22: 466. DOI: 10.1097/00002371-199909000-00058  0.544
1997 Baglia LA, Bowers WJ, Ruddell A. The avian C/EBPgamma gene encodes a highly conserved leucine zipper transcription factor. Gene. 190: 297-302. PMID 9197547 DOI: 10.1016/S0378-1119(97)00016-4  0.635
1997 Bowers WJ, Howard DF, Federoff HJ. Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease. Experimental Neurology. 144: 58-68. PMID 9126153 DOI: 10.1006/Exnr.1996.6389  0.573
1994 Bowers WJ, Petrosino JF, Smith CD, Ruddell A. Transcriptional regulation of ALV bursal lymphomagenesis. Leukemia. 8: S211-3. PMID 8152295  0.605
1992 Bowers WJ, Ruddell A. a1/EBP: a leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer. Journal of Virology. 66: 6578-86. PMID 1328681 DOI: 10.1128/Jvi.66.11.6578-6586.1992  0.635
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