William J. Bowers, Ph.D. - Publications

Neurology, Center for Neural Development and Disease University of Rochester Medical Center, Rochester, NY, United States 
CNS Gene Therapy, Immunotherapy, Neuroinflammation, Alzheimer's Disease

96 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Evans EE, Jonason AS, Bussler H, Torno S, Veeraraghavan J, Reilly C, Doherty MA, Seils J, Winter LA, Mallow C, Kirk R, Howell A, Giralico S, Scrivens M, Klimatcheva K, ... ... Bowers WJ, et al. Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies. Cancer Immunology Research. 3: 689-701. PMID 25614511 DOI: 10.1158/2326-6066.CIR-14-0171  0.4
2013 Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ. Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies. The American Journal of Pathology. 182: 2285-97. PMID 23567638 DOI: 10.1016/j.ajpath.2013.02.030  1
2012 Montgomery SL, Bowers WJ. Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 42-59. PMID 21728035 DOI: 10.1007/s11481-011-9287-2  1
2011 García-Alías G, Petrosyan HA, Schnell L, Horner PJ, Bowers WJ, Mendell LM, Fawcett JW, Arvanian VL. Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17788-99. PMID 22159095 DOI: 10.1523/JNEUROSCI.4308-11.2011  1
2011 Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL. Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. The European Journal of Neuroscience. 34: 1256-67. PMID 21995852 DOI: 10.1111/j.1460-9568.2011.07862.x  1
2011 Hunter JM, Bowers WJ, Maarouf CL, Mastrangelo MA, Daugs ID, Kokjohn TA, Kalback WM, Luehrs DC, Valla J, Beach TG, Roher AE. Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 27: 361-76. PMID 21860086 DOI: 10.3233/JAD-2011-110608  1
2011 Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Knowlden SA, Wright TW, Bowers WJ. Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain. The American Journal of Pathology. 179: 2053-70. PMID 21835156 DOI: 10.1016/j.ajpath.2011.07.001  1
2011 Domm W, Brooks L, Chung HL, Feng C, Bowers WJ, Watson G, McGrath JL, Dewhurst S. Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier. Vaccine. 29: 7080-9. PMID 21801777 DOI: 10.1016/j.vaccine.2011.07.008  1
2011 de Silva S, Bowers WJ. Targeting the central nervous system with herpes simplex virus / Sleeping Beauty hybrid amplicon vectors. Current Gene Therapy. 11: 332-40. PMID 21711226  1
2011 Bowers WJ, Breakefield XO, Sena-Esteves M. Genetic therapy for the nervous system. Human Molecular Genetics. 20: R28-41. PMID 21429918 DOI: 10.1093/hmg/ddr110  1
2011 Desai MK, Guercio BJ, Narrow WC, Bowers WJ. An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction. Glia. 59: 627-40. PMID 21294162 DOI: 10.1002/glia.21131  1
2011 Azadniv M, Bowers WJ, Topham DJ, Crispe IN. CD4+ T cell effects on CD8+ T cell location defined using bioluminescence. Plos One. 6: e16222. PMID 21283759 DOI: 10.1371/journal.pone.0016222  1
2011 Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proceedings of the National Academy of Sciences of the United States of America. 108: 852-7. PMID 21187387 DOI: 10.1073/pnas.1015981108  1
2010 Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1471-1481. PMID 28178507 DOI: 10.1038/mt.2010.111  1
2010 Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nature Medicine. 16: 998-1000. PMID 20729864 DOI: 10.1038/nm.2199  1
2010 Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ. Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target. The American Journal of Pathology. 177: 1422-35. PMID 20696774 DOI: 10.2353/ajpath.2010.100087  1
2010 Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9567-77. PMID 20631185 DOI: 10.1523/JNEUROSCI.0942-10.2010  1
2010 de Silva S, Lotta LT, Burris CA, Bowers WJ. Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform. Human Gene Therapy. 21: 1615-22. PMID 20568967 DOI: 10.1089/hum.2010.022  1
2010 Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1471-81. PMID 20551911 DOI: 10.1038/mt.2010.111  1
2010 de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Izsvák Z, Ivics Z, Bowers WJ. Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo. Human Gene Therapy. 21: 1603-13. PMID 20507234 DOI: 10.1089/hum.2010.062  1
2010 Ryan DA, Narrow WC, Federoff HJ, Bowers WJ. An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. Journal of Neuroscience Methods. 190: 171-9. PMID 20452375 DOI: 10.1016/j.jneumeth.2010.05.001  1
2010 Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. GTPase activity plays a key role in the pathobiology of LRRK2. Plos Genetics. 6: e1000902. PMID 20386743 DOI: 10.1371/journal.pgen.1000902  1
2010 Park KM, Bowers WJ. Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cellular Signalling. 22: 977-83. PMID 20096353 DOI: 10.1016/j.cellsig.2010.01.010  1
2010 Park KM, Yule DI, Bowers WJ. Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons. Cellular Signalling. 22: 519-26. PMID 19922794 DOI: 10.1016/j.cellsig.2009.11.006  1
2010 de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Federoff HJ, Bowers WJ. Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform. Gene Therapy. 17: 424-31. PMID 19865178 DOI: 10.1038/gt.2009.144  1
2010 Fong S, Chan MK, Fong A, Bowers WJ, Kelly KJ. Viral vector-induced expression of bone morphogenetic protein 2 produces inhibition of tumor growth and bone differentiation of stem cells. Cancer Gene Therapy. 17: 80-5. PMID 19834515 DOI: 10.1038/cgt.2009.56  1
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-2040. PMID 28178451 DOI: 10.1038/mt.2009.174  1
2009 de Silva S, Bowers WJ. Herpes Virus Amplicon Vectors. Viruses. 1: 594-629. PMID 19956558 DOI: 10.3390/v1030594  1
2009 Mastrangelo MA, Sudol KL, Narrow WC, Bowers WJ. Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice. The American Journal of Pathology. 175: 2076-88. PMID 19808651 DOI: 10.2353/ajpath.2009.090059  1
2009 Park KM, Yule DI, Bowers WJ. Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter. The Journal of Biological Chemistry. 284: 27557-66. PMID 19666470 DOI: 10.1074/jbc.M109.034504  1
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-40. PMID 19638957 DOI: doi:10.1038/mt.2009.174  1
2009 Bancos S, Cao Q, Bowers WJ, Crispe IN. Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4. Cellular Immunology. 257: 44-54. PMID 19306992 DOI: 10.1016/j.cellimm.2009.02.006  1
2009 Chiu YG, Bowers WJ, Lim ST, Ryan DA, Federoff HJ. Effects of herpes simplex virus amplicon transduction on murine dendritic cells. Human Gene Therapy. 20: 442-52. PMID 19199821 DOI: 10.1089/hum.2008.160  1
2009 Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ, Tolba K. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 113: 3264-75. PMID 18952891 DOI: 10.1182/blood-2008-07-168203  1
2009 Desai MK, Sudol KL, Janelsins MC, Mastrangelo MA, Frazer ME, Bowers WJ. Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia. 57: 54-65. PMID 18661556 DOI: 10.1002/glia.20734  1
2008 Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 845-853. PMID 28178487 DOI: 10.1038/mt.2008.39  1
2008 Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. The American Journal of Pathology. 173: 1768-82. PMID 18974297 DOI: 10.2353/ajpath.2008.080528  1
2008 Park KM, Yule DI, Bowers WJ. Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor. The Journal of Biological Chemistry. 283: 33069-79. PMID 18838384 DOI: 10.1074/jbc.M802209200  1
2008 Mastrangelo MA, Bowers WJ. Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice. Bmc Neuroscience. 9: 81. PMID 18700006 DOI: 10.1186/1471-2202-9-81  1
2008 Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 845-53. PMID 18388924 DOI: 10.1038/mt.2008.39  1
2008 Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff HJ, Bowers WJ. Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. The Journal of Gene Medicine. 10: 152-64. PMID 18058952 DOI: 10.1002/jgm.1130  1
2008 Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunology, Immunotherapy : Cii. 57: 663-75. PMID 17952436 DOI: 10.1007/s00262-007-0405-1  1
2007 Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD. Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Research. 67: 10027-37. PMID 17942937 DOI: 10.1158/0008-5472.CAN-06-2391  1
2007 Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S. HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine. 25: 7410-21. PMID 17868958 DOI: 10.1016/j.vaccine.2007.08.015  1
2007 Azadniv M, Dugger K, Bowers WJ, Weaver C, Crispe IN. Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporter. International Immunology. 19: 1165-73. PMID 17698980 DOI: 10.1093/intimm/dxm086  1
2007 Peterson EB, Mastrangelo MA, Federoff HJ, Bowers WJ. Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1848-55. PMID 17653102 DOI: 10.1038/sj.mt.6300267  1
2007 Santos K, Sanfilippo CM, Narrow WC, Casey AE, Rodriguez-Colon SM, McDermott MP, Federoff HJ, Bowers WJ, Dewhurst S. Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. Journal of Virological Methods. 145: 37-46. PMID 17606303 DOI: 10.1016/j.jviromet.2007.05.013  1
2007 Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S, Frelinger JG. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Human Gene Therapy. 18: 93-105. PMID 17298238 DOI: 10.1089/hum.2006.082  1
2007 Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff HJ, Collier TJ. Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival. Brain Research. 1134: 33-44. PMID 17196186 DOI: 10.1016/j.brainres.2006.11.079  1
2007 Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S. Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. 25: 1634-46. PMID 17145123 DOI: 10.1016/j.vaccine.2006.11.004  1
2006 Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. The Journal of Gene Medicine. 8: 1320-8. PMID 16989006 DOI: 10.1002/jgm.972  1
2006 Tyler CM, Wuertzer CA, Bowers WJ, Federoff HJ. HSV amplicons: neuro applications. Current Gene Therapy. 6: 337-50. PMID 16787185 DOI: 10.2174/156652306777592045  1
2006 Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff HJ. Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 580-8. PMID 16412694 DOI: 10.1016/j.ymthe.2005.11.011  1
2006 Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff HJ, Mendell LM. Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Experimental Neurology. 197: 347-52. PMID 16289170 DOI: 10.1016/j.expneurol.2005.10.008  1
2005 Federoff HJ, Bowers WJ. Immune shaping and the development of Alzheimer's disease vaccines. Science of Aging Knowledge Environment : Sage Ke. 2005: pe35. PMID 16293586 DOI: 10.1126/sageke.2005.46.pe35  1
2005 Reinblatt M, Pin RH, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Annals of Surgical Oncology. 12: 1025-36. PMID 16244806 DOI: 10.1245/ASO.2005.03.081  1
2005 Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. Journal of Neuroinflammation. 2: 23. PMID 16232318 DOI: 10.1186/1742-2094-2-23  1
2005 Corso TD, Torres G, Goulah C, Roy I, Gambino AS, Nayda J, Buckley T, Stachowiak EK, Bergey EJ, Pudavar H, Dutta P, Bloom DC, Bowers WJ, Stachowiak MK. Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods. Folia Morphologica. 64: 130-44. PMID 16228947  1
2005 Corso TD, Torres G, Goulah C, Roy I, Gambino AS, Nayda J, Buckley T, Stachowiak EK, Bergey EJ, Pudavar H, Dutta P, Bloom DC, Bowers WJ, Stachowiak MK. Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Brain Research. Molecular Brain Research. 139: 361-6. PMID 16039006 DOI: 10.1016/j.molbrainres.2005.05.032  1
2005 Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L. Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. Journal of Virology. 79: 2124-32. PMID 15681415 DOI: 10.1128/JVI.79.4.2124-2132.2005  1
2005 Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff HJ. HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiology of Aging. 26: 393-407. PMID 15653168 DOI: 10.1016/j.neurobiolaging.2004.04.006  1
2004 Pin RH, Reinblatt M, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 8: 812-22; discussion 8. PMID 15531234 DOI: 10.1016/j.gassur.2004.08.007  1
2004 Arvanian VL, Bowers WJ, Petruska JC, Motin V, Manuzon H, Narrow WC, Federoff HJ, Mendell LM. Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. Journal of Neurophysiology. 92: 2394-404. PMID 15152019 DOI: 10.1152/jn.00278.2004  1
2003 Kyrkanides S, Miller Jn, Bowers WJ, Federoff HJ. Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 790-5. PMID 14599812 DOI: 10.1016/j.ymthe.2003.07.005  1
2003 Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff HJ. HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury. Experimental Neurology. 183: 47-55. PMID 12957487 DOI: 10.1016/S0014-4886(03)00080-3  1
2003 Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7385-94. PMID 12917374  1
2003 Bowers WJ, Olschowka JA, Federoff HJ. Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy. Gene Therapy. 10: 941-5. PMID 12756414 DOI: 10.1038/sj.gt.3302047  1
2003 Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 21: 2288-97. PMID 12744859 DOI: 10.1016/S0264-410X(03)00099-9  1
2003 Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 218-27. PMID 12597910 DOI: 10.1016/S1525-0016(02)00036-9  1
2003 Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nature Medicine. 9: 231-5. PMID 12539041 DOI: 10.1038/nm821  1
2002 Wang SW, Mu X, Bowers WJ, Klein WH. Retinal ganglion cell differentiation in cultured mouse retinal explants. Methods (San Diego, Calif.). 28: 448-56. PMID 12507463 DOI: 10.1016/S1046-2023(02)00264-5  1
2002 Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. Cancer Research. 62: 6545-51. PMID 12438249  1
2002 Maguire-Zeiss KA, Bowers WJ, Federoff HJ. Somatic mosaic approaches and the aging brain. Neurobiology of Aging. 23: 977-84. PMID 12392799 DOI: 10.1016/S0197-4580(02)00077-5  1
2002 Bowers WJ, Federoff HJ. Amyloid immunotherapy-engendered CNS inflammation. Neurobiology of Aging. 23: 675-6; discussion 68. PMID 12392770 DOI: 10.1016/S0197-4580(02)00035-0  1
2002 Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff HJ, Rosenblatt JD. HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 455-63. PMID 12377186 DOI: 10.1006/mthe.2002.0693  1
2002 Mankodi A, Takahashi MP, Jiang H, Beck CL, Bowers WJ, Moxley RT, Cannon SC, Thornton CA. Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy. Molecular Cell. 10: 35-44. PMID 12150905 DOI: 10.1016/S1097-2765(02)00563-4  1
2002 Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (New York, N.Y.). 297: 259-63. PMID 12114629 DOI: 10.1126/science.1072221  1
2002 Bowers WJ, Chen X, Guo H, Frisina DR, Federoff HJ, Frisina RD. Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 12-8. PMID 12095298 DOI: 10.1006/mthe.2002.0627  1
2002 Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. Reporter gene transfer induces apoptosis in primary cortical neurons. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 723-30. PMID 12027556 DOI: 10.1006/mthe.2002.0609  1
2002 Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S. Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. Journal of Virology. 76: 5565-80. PMID 11991985 DOI: 10.1128/JVI.76.11.5565-5580.2002  1
2002 Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff HJ, Bowers WJ. Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 300-6. PMID 11863420 DOI: 10.1006/mthe.2002.0539  1
2002 Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development (Cambridge, England). 129: 467-77. PMID 11807038  1
2001 Maguire-Zeiss KA, Bowers WJ, Federoff HJ. HSV vector-mediated gene delivery to the central nervous system. Current Opinion in Molecular Therapeutics. 3: 482-90. PMID 11699893  1
2001 Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff HJ, Lord EM, Frelinger JG. Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice. Human Gene Therapy. 12: 1867-79. PMID 11589829 DOI: 10.1089/104303401753153929  1
2001 Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G. Regulation of neuronal traits by a novel transcriptional complex. Neuron. 31: 353-65. PMID 11516394 DOI: 10.1016/S0896-6273(01)00371-3  1
2001 Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 98: 287-95. PMID 11435295 DOI: 10.1182/blood.V98.2.287  1
2001 Chen X, Frisina RD, Bowers WJ, Frisina DR, Federoff HJ. HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 958-63. PMID 11407910 DOI: 10.1006/mthe.2001.0334  1
2001 Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Therapy. 8: 111-20. PMID 11313780 DOI: 10.1038/sj.gt.3301340  1
2001 Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 410: 89-93. PMID 11242047 DOI: 10.1038/35065091  1
2000 Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff HJ. Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. Human Gene Therapy. 11: 2341-52. PMID 11096439 DOI: 10.1089/104303400750038453  1
2000 Bowers WJ, Howard DF, Federoff HJ. Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 294-9. PMID 10933945 DOI: 10.1006/mthe.2000.0039  1
1997 Baglia LA, Bowers WJ, Ruddell A. The avian C/EBPgamma gene encodes a highly conserved leucine zipper transcription factor. Gene. 190: 297-302. PMID 9197547 DOI: 10.1016/S0378-1119(97)00016-4  1
1997 Bowers WJ, Howard DF, Federoff HJ. Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease. Experimental Neurology. 144: 58-68. PMID 9126153 DOI: 10.1006/exnr.1996.6389  1
1996 Bowers WJ, Baglia LA, Ruddel A. Regulation of avian leukosis virus long terminal repeat-enhanced transcription by C/EBP-Rel interactions. Journal of Virology. 70: 3051-9. PMID 8627783  1
1994 Bowers WJ, Petrosino JF, Smith CD, Ruddell A. Transcriptional regulation of ALV bursal lymphomagenesis. Leukemia. 8: S211-3. PMID 8152295  1
1992 Bowers WJ, Ruddell A. a1/EBP: a leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer. Journal of Virology. 66: 6578-86. PMID 1328681  1
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