| Year |
Citation |
Score |
| 2023 |
Duncan-Lowey J, Crabill E, Jarret A, Reed SCO, Roy CR. The effector EmcB is a deubiquitinase that inhibits RIG-I signaling. Proceedings of the National Academy of Sciences of the United States of America. 120: e2217602120. PMID 36893270 DOI: 10.1073/pnas.2217602120 |
0.833 |
|
| 2023 |
Ganesan S, Alvarez NN, Steiner S, Fowler KM, Corona AK, Roy CR. Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection. Mbio. e0354522. PMID 36728431 DOI: 10.1128/mbio.03545-22 |
0.487 |
|
| 2022 |
Park D, Steiner S, Shao M, Roy CR, Liu J. Developmental Transitions Coordinate Assembly of the Coxiella burnetii Dot/Icm Type IV Secretion System. Infection and Immunity. e0041022. PMID 36190257 DOI: 10.1128/iai.00410-22 |
0.32 |
|
| 2021 |
Macé K, Meir A, Lukoyanova N, Liu L, Chetrit D, Hospenthal MK, Roy CR, Waksman G. The proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila. Molecular Microbiology. PMID 34816517 DOI: 10.1111/mmi.14847 |
0.682 |
|
| 2021 |
Liu L, Roy CR. The effector RavY contributes to a replication-permissive vacuolar environment during infection. Infection and Immunity. IAI0026121. PMID 34543123 DOI: 10.1128/IAI.00261-21 |
0.722 |
|
| 2021 |
Steiner S, Meir A, Roy CR. Coxiella burnetii encodes an LvgA-related protein important for intracellular replication. Cellular Microbiology. e13331. PMID 33774901 DOI: 10.1111/cmi.13331 |
0.424 |
|
| 2020 |
Meir A, Macé K, Lukoyanova N, Chetrit D, Hospenthal MK, Redzej A, Roy C, Waksman G. Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila. Nature Communications. 11: 2864. PMID 32513920 DOI: 10.1038/S41467-020-16681-Z |
0.443 |
|
| 2020 |
Omotade TO, Roy CR. excludes autophagy adaptors from the ubiquitin-labeled vacuole in which it resides. Infection and Immunity. PMID 32482642 DOI: 10.1128/Iai.00793-19 |
0.44 |
|
| 2020 |
Chetrit D, Park D, Hu B, Liu J, Roy CR. Applying Live Cell Imaging and Cryo-Electron Tomography to Resolve Spatiotemporal Features of the Legionella pneumophila Dot/Icm Secretion System. Journal of Visualized Experiments : Jove. PMID 32225141 DOI: 10.3791/60693 |
0.424 |
|
| 2020 |
Newton P, Thomas DR, Reed SCO, Lau N, Xu B, Ong SY, Pasricha S, Madhamshettiwar PB, Edgington-Mitchell LE, Simpson KJ, Roy CR, Newton HJ. Lysosomal degradation products induce virulence. Proceedings of the National Academy of Sciences of the United States of America. PMID 32152125 DOI: 10.1073/Pnas.1921344117 |
0.529 |
|
| 2020 |
Park D, Chetrit D, Hu B, Roy CR, Liu J. Analysis of Dot/Icm Type IVB Secretion System Subassemblies by Cryoelectron Tomography Reveals Conformational Changes Induced by DotB Binding. Mbio. 11. PMID 32071271 DOI: 10.1128/Mbio.03328-19 |
0.459 |
|
| 2019 |
Padmanabhan B, Fielden LF, Hachani A, Newton P, Thomas DR, Cho HJ, Khoo CA, Stojanovski D, Roy CR, Scott NE, Newton HJ. Biogenesis of the spacious -containing vacuole depends on host transcription factors TFEB and TFE3. Infection and Immunity. PMID 31818957 DOI: 10.1128/Iai.00534-19 |
0.549 |
|
| 2019 |
Inaba JI, Xu K, Kovalev N, Ramanathan H, Roy CR, Lindenbach BD, Nagy PD. Screening effectors for antiviral effects reveals Rab1 GTPase as a proviral factor coopted for tombusvirus replication. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591191 DOI: 10.1073/Pnas.1911108116 |
0.497 |
|
| 2019 |
Ganesan S, Roy CR. Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii. Plos Pathogens. 15: e1007955. PMID 31461509 DOI: 10.1371/Journal.Ppat.1007955 |
0.514 |
|
| 2019 |
Omotade TO, Roy CR. Manipulation of Host Cell Organelles by Intracellular Pathogens. Microbiology Spectrum. 7. PMID 31025623 DOI: 10.1128/Microbiolspec.Bai-0022-2019 |
0.518 |
|
| 2018 |
Arasaki K, Kimura H, Tagaya M, Roy CR. remodels the plasma membrane-derived vacuole by utilizing exocyst components as tethers. The Journal of Cell Biology. PMID 30275106 DOI: 10.1083/Jcb.201801208 |
0.429 |
|
| 2018 |
Chetrit D, Hu B, Christie PJ, Roy CR, Liu J. A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel. Nature Microbiology. PMID 29784975 DOI: 10.1038/S41564-018-0165-Z |
0.348 |
|
| 2018 |
Meir A, Chetrit D, Liu L, Roy CR, Waksman G. Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system. Nature Communications. 9: 507. PMID 29410427 DOI: 10.1038/S41467-017-02578-X |
0.694 |
|
| 2018 |
Crabill E, Schofield WB, Newton HJ, Goodman AL, Roy CR. Dot/Icm-translocated proteins important for biogenesis of the Coxiella burnetii-containing vacuole identified by screening of an effector mutant sub-library. Infection and Immunity. PMID 29339460 DOI: 10.1128/Iai.00758-17 |
0.82 |
|
| 2017 |
Hilbi H, Nagai H, Kubori T, Roy CR. Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System. Current Topics in Microbiology and Immunology. 413: 221-242. PMID 29536361 DOI: 10.1007/978-3-319-75241-9_9 |
0.586 |
|
| 2017 |
Shames SR, Liu L, Havey JC, Schofield WB, Goodman AL, Roy CR. Multiple Legionella pneumophila effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries. Proceedings of the National Academy of Sciences of the United States of America. PMID 29133401 DOI: 10.1073/Pnas.1708553114 |
0.765 |
|
| 2017 |
Guzmán-Herrador DL, Steiner S, Alperi A, González-Prieto C, Roy CR, Llosa M. DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens. Frontiers in Microbiology. 8: 1503. PMID 28878740 DOI: 10.3389/Fmicb.2017.01503 |
0.338 |
|
| 2017 |
Fielden LF, Moffatt JH, Kang Y, Baker MJ, Khoo CA, Roy CR, Stojanovski D, Newton HJ. A farnesylated Coxiella burnetii effector forms a multimeric complex at the mitochondrial outer membrane during infection. Infection and Immunity. PMID 28242621 DOI: 10.1128/Iai.01046-16 |
0.449 |
|
| 2017 |
Tørring T, Shames SR, Cho W, Roy CR, Crawford J. Acyl-histidines: New N-acyl amides from Legionella pneumophila. Chembiochem : a European Journal of Chemical Biology. PMID 28116768 DOI: 10.1002/Cbic.201600618 |
0.446 |
|
| 2016 |
Kohler LJ, Roy CR. Autophagic targeting and avoidance in intracellular bacterial infections. Current Opinion in Microbiology. 35: 36-41. PMID 27984783 DOI: 10.1016/J.Mib.2016.11.004 |
0.507 |
|
| 2016 |
Abshire CF, Dragoi AM, Roy CR, Ivanov SS. MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis. Plos Pathogens. 12: e1006088. PMID 27942021 DOI: 10.1371/Journal.Ppat.1006088 |
0.543 |
|
| 2016 |
Sherwood RK, Roy CR. Autophagy Evasion and Endoplasmic Reticulum Subversion: The Yin and Yang of Legionella Intracellular Infection. Annual Review of Microbiology. 70: 413-33. PMID 27607556 DOI: 10.1146/Annurev-Micro-102215-095557 |
0.581 |
|
| 2016 |
Kohler LJ, Reed SC, Sarraf SA, Arteaga DD, Newton HJ, Roy CR. Erratum for Kohler et al., Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. Mbio. 7. PMID 27601576 DOI: 10.1128/Mbio.01327-16 |
0.38 |
|
| 2016 |
Campodonico EM, Roy CR, Ninio S. Legionella pneumophila Type IV Effectors YlfA and YlfB Are SNARE-Like Proteins that Form Homo- and Heteromeric Complexes and Enhance the Efficiency of Vacuole Remodeling. Plos One. 11: e0159698. PMID 27459495 DOI: 10.1371/Journal.Pone.0159698 |
0.849 |
|
| 2016 |
Kohler LJ, Reed SR, Sarraf SA, Arteaga DD, Newton HJ, Roy CR. Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. Mbio. 7. PMID 27435465 DOI: 10.1128/Mbio.01127-16 |
0.537 |
|
| 2016 |
Marion CR, Wang J, Sharma L, Losier A, Lui W, Andrews N, Elias JA, Kazmierczak BI, Roy CR, Dela Cruz CS. Chitinase 3-like-1 (Chil1) Regulates Survival and Macrophage-mediated IL-1β and TNF-α during Pseudomonas Pneumonia. Infection and Immunity. PMID 27141083 DOI: 10.1128/Iai.00055-16 |
0.385 |
|
| 2016 |
Bradley WP, Boyer MA, Nguyen HT, Birdwell LD, Yu J, Ribeiro JM, Weiss SR, Zamboni DS, Roy CR, Shin S. Primary role for TLR-driven TNF rather than cytosolic immune detection in restricting Coxiella burnetii phase II replication within mouse macrophages. Infection and Immunity. PMID 26787725 DOI: 10.1128/Iai.01536-15 |
0.681 |
|
| 2015 |
Cunha LD, Ribeiro JM, Fernandes TD, Massis LM, Khoo CA, Moffatt JH, Newton HJ, Roy CR, Zamboni DS. Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA. Nature Communications. 6: 10205. PMID 26687278 DOI: 10.1038/Ncomms10205 |
0.672 |
|
| 2015 |
Horenkamp FA, Kauffman KJ, Kohler LJ, Sherwood RK, Krueger KP, Shteyn V, Roy CR, Melia TJ, Reinisch KM. The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs. Developmental Cell. 34: 569-76. PMID 26343456 DOI: 10.1016/J.Devcel.2015.08.010 |
0.48 |
|
| 2015 |
Kohler LJ, Roy CR. Biogenesis of the lysosome-derived vacuole containing Coxiella burnetii. Microbes and Infection / Institut Pasteur. PMID 26327296 DOI: 10.1016/J.Micinf.2015.08.006 |
0.411 |
|
| 2015 |
Roy CR, Cherfils J. Structure and function of Fic proteins. Nature Reviews. Microbiology. 13: 631-40. PMID 26299785 DOI: 10.1038/Nrmicro3520 |
0.469 |
|
| 2015 |
Havey JC, Roy CR. Toxicity and SidJ-Mediated Suppression of Toxicity Require Distinct Regions in the SidE Family of Legionella pneumophila Effectors. Infection and Immunity. 83: 3506-14. PMID 26099583 DOI: 10.1128/Iai.00497-15 |
0.504 |
|
| 2015 |
Folly-Klan M, Sancerne B, Alix E, Roy CR, Cherfils J, Campanacci V. On the use of Legionella/Rickettsia chimeras to investigate the structure and regulation of Rickettsia effector RalF. Journal of Structural Biology. 189: 98-104. PMID 25498244 DOI: 10.1016/J.Jsb.2014.12.001 |
0.353 |
|
| 2014 |
Copenhaver AM, Casson CN, Nguyen HT, Fung TC, Duda MM, Roy CR, Shin S. Alveolar macrophages and neutrophils are the primary reservoirs for Legionella pneumophila and mediate cytosolic surveillance of type IV secretion. Infection and Immunity. 82: 4325-36. PMID 25092908 DOI: 10.1128/Iai.01891-14 |
0.533 |
|
| 2014 |
Newton HJ, Kohler LJ, McDonough JA, Temoche-Diaz M, Crabill E, Hartland EL, Roy CR. A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis. Plos Pathogens. 10: e1004286. PMID 25080348 DOI: 10.1371/Journal.Ppat.1004286 |
0.833 |
|
| 2014 |
Hubber A, Arasaki K, Nakatsu F, Hardiman C, Lambright D, De Camilli P, Nagai H, Roy CR. The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. Plos Pathogens. 10: e1004222. PMID 24992562 DOI: 10.1371/Journal.Ppat.1004222 |
0.835 |
|
| 2014 |
Del Campo CM, Mishra AK, Wang YH, Roy CR, Janmey PA, Lambright DG. Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM. Structure (London, England : 1993). 22: 397-408. PMID 24530282 DOI: 10.1016/J.Str.2013.12.018 |
0.336 |
|
| 2014 |
Hardiman CA, Roy CR. AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila. Mbio. 5: e01035-13. PMID 24520063 DOI: 10.1128/Mbio.01035-13 |
0.828 |
|
| 2014 |
Horenkamp FA, Mukherjee S, Alix E, Schauder CM, Hubber AM, Roy CR, Reinisch KM. Legionella pneumophila subversion of host vesicular transport by SidC effector proteins. Traffic (Copenhagen, Denmark). 15: 488-99. PMID 24483784 DOI: 10.1111/Tra.12158 |
0.525 |
|
| 2014 |
Newton HJ, Kohler LJ, McDonough JA, Temoche-Diaz M, Crabill E, Hartland EL, Roy CR. Autophagy is required for homotypic fusion of CCVs. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1004286.G005 |
0.771 |
|
| 2013 |
Casanova JE, Hsu VW, Jackson CL, Kahn RA, Roy CR, Stow JL, Wandinger-Ness A, Sztul E. Meeting report - Arf and Rab family G proteins. Journal of Cell Science. 126: 5313-6. PMID 24293329 DOI: 10.1242/Jcs.143610 |
0.302 |
|
| 2013 |
Folly-Klan M, Alix E, Stalder D, Ray P, Duarte LV, Delprato A, Zeghouf M, Antonny B, Campanacci V, Roy CR, Cherfils J. A Novel Membrane Sensor Controls the Localization and ArfGEF Activity of Bacterial RalF Plos Pathogens. 9. PMID 24244168 DOI: 10.1371/Journal.Ppat.1003747 |
0.425 |
|
| 2013 |
Ivanov SS, Roy CR. Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR. Nature Immunology. 14: 1219-28. PMID 24121838 DOI: 10.1038/Ni.2740 |
0.513 |
|
| 2013 |
Sherwood RK, Roy CR. A Rab-centric perspective of bacterial pathogen-occupied vacuoles. Cell Host & Microbe. 14: 256-68. PMID 24034612 DOI: 10.1016/J.Chom.2013.08.010 |
0.494 |
|
| 2013 |
Ivanov SS, Roy C. Host lipidation: a mechanism for spatial regulation of Legionella effectors. Current Topics in Microbiology and Immunology. 376: 135-54. PMID 23918175 DOI: 10.1007/82_2013_344 |
0.516 |
|
| 2013 |
Choy A, Roy CR. Autophagy and bacterial infection: an evolving arms race. Trends in Microbiology. 21: 451-6. PMID 23880062 DOI: 10.1016/J.Tim.2013.06.009 |
0.695 |
|
| 2013 |
Hori JI, Pereira MS, Roy CR, Nagai H, Zamboni DS. Identification and functional characterization of K(+) transporters encoded by Legionella pneumophila kup genes. Cellular Microbiology. 15: 2006-19. PMID 23848378 DOI: 10.1111/Cmi.12168 |
0.661 |
|
| 2013 |
Mishra AK, Del Campo CM, Collins RE, Roy CR, Lambright DG. The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism. The Journal of Biological Chemistry. 288: 24000-11. PMID 23821544 DOI: 10.1074/Jbc.M113.470625 |
0.349 |
|
| 2013 |
Campanacci V, Mukherjee S, Roy CR, Cherfils J. Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain. The Embo Journal. 32: 1469-77. PMID 23572077 DOI: 10.1038/Emboj.2013.82 |
0.442 |
|
| 2013 |
McDonough JA, Newton HJ, Klum S, Swiss R, Agaisse H, Roy CR. Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening. Mbio. 4: e00606-12. PMID 23362322 DOI: 10.1128/Mbio.00606-12 |
0.471 |
|
| 2013 |
Jamilloux Y, Pierini R, Querenet M, Juruj C, Fauchais AL, Jauberteau MO, Jarraud S, Lina G, Etienne J, Roy CR, Henry T, Davoust N, Ader F. Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection. Glia. 61: 539-49. PMID 23355222 DOI: 10.1002/Glia.22454 |
0.439 |
|
| 2013 |
Newton HJ, McDonough JA, Roy CR. Effector protein translocation by the Coxiella burnetii Dot/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuole. Plos One. 8: e54566. PMID 23349930 DOI: 10.1371/Journal.Pone.0054566 |
0.573 |
|
| 2013 |
Case CL, Kohler LJ, Lima JB, Strowig T, de Zoete MR, Flavell RA, Zamboni DS, Roy CR. Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proceedings of the National Academy of Sciences of the United States of America. 110: 1851-6. PMID 23307811 DOI: 10.1073/Pnas.1211521110 |
0.75 |
|
| 2013 |
Case CL, Roy CR. Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages. Methods in Molecular Biology (Clifton, N.J.). 954: 479-91. PMID 23150415 DOI: 10.1007/978-1-62703-161-5_29 |
0.653 |
|
| 2013 |
Cherfils J, Folly-Klan M, Alix E, Roy CR, Stalder D, Antonny B, Campanacci V. HowLegionelladiverts host small GTPases: structural and biochemical studies Acta Crystallographica Section a Foundations of Crystallography. 69: s313-s313. DOI: 10.1107/S0108767313097298 |
0.374 |
|
| 2012 |
Hardiman CA, McDonough JA, Newton HJ, Roy CR. The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii. Biochemical Society Transactions. 40: 1353-9. PMID 23176480 DOI: 10.1042/Bst20120167 |
0.838 |
|
| 2012 |
Alix E, Chesnel L, Bowzard BJ, Tucker AM, Delprato A, Cherfils J, Wood DO, Kahn RA, Roy CR. The capping domain in RalF regulates effector functions. Plos Pathogens. 8: e1003012. PMID 23166491 DOI: 10.1371/Journal.Ppat.1003012 |
0.432 |
|
| 2012 |
Choy A, Dancourt J, Mugo B, O'Connor TJ, Isberg RR, Melia TJ, Roy CR. The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (New York, N.Y.). 338: 1072-6. PMID 23112293 DOI: 10.1126/Science.1227026 |
0.821 |
|
| 2012 |
McDonough JA, Newton HJ, Roy CR. Coxiella burnetii secretion systems Advances in Experimental Medicine and Biology. 984: 171-197. PMID 22711632 DOI: 10.1007/978-94-007-4315-1_9 |
0.563 |
|
| 2012 |
Roy CR. Vacuolar pathogens value membrane integrity. Proceedings of the National Academy of Sciences of the United States of America. 109: 3197-8. PMID 22343287 DOI: 10.1073/Pnas.1200326109 |
0.515 |
|
| 2012 |
Arasaki K, Toomre DK, Roy CR. The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion. Cell Host & Microbe. 11: 46-57. PMID 22264512 DOI: 10.1016/J.Chom.2011.11.009 |
0.465 |
|
| 2011 |
Alix E, Mukherjee S, Roy CR. Subversion of membrane transport pathways by vacuolar pathogens. The Journal of Cell Biology. 195: 943-52. PMID 22123831 DOI: 10.1083/Jcb.201105019 |
0.468 |
|
| 2011 |
Newton HJ, Roy CR. The Coxiella burnetii Dot/Icm system creates a comfortable home through lysosomal renovation. Mbio. 2. PMID 22010216 DOI: 10.1128/Mbio.00226-11 |
0.372 |
|
| 2011 |
Mukherjee S, Liu X, Arasaki K, McDonough J, Galán JE, Roy CR. Modulation of Rab GTPase function by a protein phosphocholine transferase. Nature. 477: 103-6. PMID 21822290 DOI: 10.1038/Nature10335 |
0.561 |
|
| 2011 |
Lippmann J, Müller HC, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B. Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice. Cellular Microbiology. 13: 1668-82. PMID 21790939 DOI: 10.1111/J.1462-5822.2011.01646.X |
0.456 |
|
| 2011 |
Case CL, Roy CR. Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila. Mbio. 2. PMID 21771913 DOI: 10.1128/Mbio.00117-11 |
0.678 |
|
| 2011 |
Carey KL, Newton HJ, Lührmann A, Roy CR. The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication. Plos Pathogens. 7: e1002056. PMID 21637816 DOI: 10.1371/Journal.Ppat.1002056 |
0.535 |
|
| 2010 |
Lührmann A, Nogueira CV, Carey KL, Roy CR. Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proceedings of the National Academy of Sciences of the United States of America. 107: 18997-9001. PMID 20944063 DOI: 10.1073/Pnas.1004380107 |
0.579 |
|
| 2010 |
Hubber A, Roy CR. Modulation of host cell function by Legionella pneumophila type IV effectors. Annual Review of Cell and Developmental Biology. 26: 261-83. PMID 20929312 DOI: 10.1146/Annurev-Cellbio-100109-104034 |
0.582 |
|
| 2010 |
Ivanov SS, Charron G, Hang HC, Roy CR. Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. The Journal of Biological Chemistry. 285: 34686-98. PMID 20813839 DOI: 10.1074/Jbc.M110.170746 |
0.541 |
|
| 2010 |
Cossart P, Roy CR. Manipulation of host membrane machinery by bacterial pathogens. Current Opinion in Cell Biology. 22: 547-54. PMID 20542678 DOI: 10.1016/J.Ceb.2010.05.006 |
0.502 |
|
| 2010 |
Archer KA, Ader F, Kobayashi KS, Flavell RA, Roy CR. Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila. Infection and Immunity. 78: 2477-87. PMID 20351139 DOI: 10.1128/Iai.00243-10 |
0.768 |
|
| 2010 |
Huang B, Hubber A, McDonough JA, Roy CR, Scidmore MA, Carlyon JA. The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes Cellular Microbiology. 12: 1292-1307. PMID 20345488 DOI: 10.1111/J.1462-5822.2010.01468.X |
0.471 |
|
| 2010 |
Arasaki K, Roy CR. Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b. Traffic (Copenhagen, Denmark). 11: 587-600. PMID 20163564 DOI: 10.1111/J.1600-0854.2010.01050.X |
0.435 |
|
| 2009 |
Ivanov S, Roy CR. NDP52: the missing link between ubiquitinated bacteria and autophagy. Nature Immunology. 10: 1137-9. PMID 19841643 DOI: 10.1038/Ni1109-1137 |
0.471 |
|
| 2009 |
Nogueira CV, Lindsten T, Jamieson AM, Case CL, Shin S, Thompson CB, Roy CR. Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. Plos Pathogens. 5: e1000478. PMID 19521510 DOI: 10.1371/Journal.Ppat.1000478 |
0.688 |
|
| 2009 |
Llosa M, Roy C, Dehio C. Bacterial type IV secretion systems in human disease. Molecular Microbiology. 73: 141-51. PMID 19508287 DOI: 10.1111/J.1365-2958.2009.06751.X |
0.386 |
|
| 2009 |
Raychaudhury S, Farelli JD, Montminy TP, Matthews M, Ménétret JF, Duménil G, Roy CR, Head JF, Isberg RR, Akey CW. Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure (London, England : 1993). 17: 590-601. PMID 19368892 DOI: 10.1016/J.Str.2009.02.011 |
0.769 |
|
| 2009 |
Roy CR, Mukherjee S. Bacterial FIC Proteins AMP Up Infection. Science Signaling. 2: pe14. PMID 19293428 DOI: 10.1126/Scisignal.262Pe14 |
0.507 |
|
| 2009 |
Case CL, Shin S, Roy CR. Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila. Infection and Immunity. 77: 1981-91. PMID 19237518 DOI: 10.1128/Iai.01382-08 |
0.697 |
|
| 2009 |
Ninio S, Celli J, Roy CR. A Legionella pneumophila effector protein encoded in a region of genomic plasticity binds to Dot/Icm-modified vacuoles. Plos Pathogens. 5: e1000278. PMID 19165328 DOI: 10.1371/Journal.Ppat.1000278 |
0.523 |
|
| 2009 |
Ivanov SS, Roy CR. Modulation of ubiquitin dynamics and suppression of DALIS formation by the Legionella pneumophila Dot/Icm system. Cellular Microbiology. 11: 261-78. PMID 19016782 DOI: 10.1111/J.1462-5822.2008.01251.X |
0.53 |
|
| 2009 |
Archer KA, Alexopoulou L, Flavell RA, Roy CR. Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila. Cellular Microbiology. 11: 21-36. PMID 18782351 DOI: 10.1111/J.1462-5822.2008.01234.X |
0.747 |
|
| 2009 |
Ingmundson A, Roy CR. Legionella Pneumophila Intracellular Niches of Microbes: a Pathogens Guide Through the Host Cell. 315-325. DOI: 10.1002/9783527629176.ch18 |
0.768 |
|
| 2008 |
Shin S, Case CL, Archer KA, Nogueira CV, Kobayashi KS, Flavell RA, Roy CR, Zamboni DS. Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. Plos Pathogens. 4: e1000220. PMID 19043549 DOI: 10.1371/Journal.Ppat.1000220 |
0.829 |
|
| 2008 |
Pan X, Lührmann A, Satoh A, Laskowski-Arce MA, Roy CR. Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science (New York, N.Y.). 320: 1651-4. PMID 18566289 DOI: 10.1126/Science.1158160 |
0.736 |
|
| 2008 |
Ingmundson A, Roy CR. Analyzing association of the endoplasmic reticulum with the legionella pneumophila-containing vacuoles by fluorescence microscopy. Methods in Molecular Biology (Clifton, N.J.). 445: 379-87. PMID 18425463 DOI: 10.1007/978-1-59745-157-4_24 |
0.785 |
|
| 2008 |
Shin S, Roy CR. Host cell processes that influence the intracellular survival of Legionella pneumophila. Cellular Microbiology. 10: 1209-20. PMID 18363881 DOI: 10.1111/J.1462-5822.2008.01145.X |
0.529 |
|
| 2007 |
Cambronne ED, Roy CR. The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocation. Plos Pathogens. 3: e188. PMID 18069892 DOI: 10.1371/Journal.Ppat.0030188 |
0.485 |
|
| 2007 |
Ingmundson A, Delprato A, Lambright DG, Roy CR. Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature. 450: 365-9. PMID 17952054 DOI: 10.1038/Nature06336 |
0.812 |
|
| 2007 |
Roy CR, Mocarski ES. Pathogen subversion of cell-intrinsic innate immunity. Nature Immunology. 8: 1179-87. PMID 17952043 DOI: 10.1038/Ni1528 |
0.457 |
|
| 2007 |
Lührmann A, Roy CR. Coxiella burnetii inhibits activation of host cell apoptosis through a mechanism that involves preventing cytochrome c release from mitochondria. Infection and Immunity. 75: 5282-9. PMID 17709406 DOI: 10.1128/Iai.00863-07 |
0.436 |
|
| 2007 |
Ninio S, Roy CR. Effector proteins translocated by Legionella pneumophila: strength in numbers. Trends in Microbiology. 15: 372-80. PMID 17632005 DOI: 10.1016/J.Tim.2007.06.006 |
0.572 |
|
| 2006 |
Sutterwala FS, Ogura Y, Zamboni DS, Roy CR, Flavell RA. NALP3: a key player in caspase-1 activation. Journal of Endotoxin Research. 12: 251-6. PMID 16953978 DOI: 10.1177/09680519060120040701 |
0.595 |
|
| 2006 |
Murata T, Delprato A, Ingmundson A, Toomre DK, Lambright DG, Roy CR. The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor. Nature Cell Biology. 8: 971-7. PMID 16906144 DOI: 10.1038/Ncb1463 |
0.829 |
|
| 2006 |
Cambronne ED, Roy CR. Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems. Traffic (Copenhagen, Denmark). 7: 929-39. PMID 16734660 DOI: 10.1111/J.1600-0854.2006.00446.X |
0.485 |
|
| 2006 |
Roy CR, Zamboni DS. Cytosolic detection of flagellin: a deadly twist. Nature Immunology. 7: 549-51. PMID 16715062 DOI: 10.1038/Ni0606-549 |
0.699 |
|
| 2006 |
Archer KA, Roy CR. MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnaires' disease. Infection and Immunity. 74: 3325-33. PMID 16714560 DOI: 10.1128/Iai.02049-05 |
0.767 |
|
| 2006 |
Robinson CG, Roy CR. Attachment and fusion of endoplasmic reticulum with vacuoles containing Legionella pneumophila. Cellular Microbiology. 8: 793-805. PMID 16611228 DOI: 10.1111/J.1462-5822.2005.00666.X |
0.687 |
|
| 2006 |
Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. Plos Pathogens. 2: e18. PMID 16552444 DOI: 10.1371/Journal.Ppat.0020018 |
0.688 |
|
| 2006 |
Roy CR, Salcedo SP, Gorvel JP. Pathogen-endoplasmic-reticulum interactions: in through the out door. Nature Reviews. Immunology. 6: 136-47. PMID 16491138 DOI: 10.1038/Nri1775 |
0.487 |
|
| 2006 |
Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE, Kuida K, Mariathasan S, Dixit VM, Flavell RA, Dietrich WF, Roy CR. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nature Immunology. 7: 318-25. PMID 16444259 DOI: 10.1038/Ni1305 |
0.712 |
|
| 2005 |
Kagan JC, Murata T, Roy CR. Analysis of Rab1 recruitment to vacuoles containing Legionella pneumophila. Methods in Enzymology. 403: 71-81. PMID 16473578 DOI: 10.1016/S0076-6879(05)03007-7 |
0.748 |
|
| 2005 |
Neild AL, Shin S, Roy CR. Activated macrophages infected with Legionella inhibit T cells by means of MyD88-dependent production of prostaglandins. Journal of Immunology (Baltimore, Md. : 1950). 175: 8181-90. PMID 16339557 DOI: 10.4049/Jimmunol.175.12.8181 |
0.802 |
|
| 2005 |
Roy CR. Trimming the fat: a Brucella abortus survival strategy. Nature Immunology. 6: 546-8. PMID 15908934 DOI: 10.1038/Ni0605-546 |
0.31 |
|
| 2005 |
Campodonico EM, Chesnel L, Roy CR. A yeast genetic system for the identification and characterization of substrate proteins transferred into host cells by the Legionella pneumophila Dot/Icm system. Molecular Microbiology. 56: 918-33. PMID 15853880 DOI: 10.1111/J.1365-2958.2005.04595.X |
0.824 |
|
| 2005 |
Neild A, Murata T, Roy CR. Processing and major histocompatibility complex class II presentation of Legionella pneumophila antigens by infected macrophages. Infection and Immunity. 73: 2336-43. PMID 15784579 DOI: 10.1128/Iai.73.4.2336-2343.2005 |
0.812 |
|
| 2005 |
Roy CR. Bacterial subversion of the host secretory pathway. Proceedings of the National Academy of Sciences of the United States of America. 102: 1271-2. PMID 15677328 DOI: 10.1073/Pnas.0409531101 |
0.438 |
|
| 2005 |
Ninio S, Zuckman-Cholon DM, Cambronne ED, Roy CR. The Legionella IcmS-IcmW protein complex is important for Dot/Icm-mediated protein translocation. Molecular Microbiology. 55: 912-26. PMID 15661013 DOI: 10.1111/J.1365-2958.2004.04435.X |
0.508 |
|
| 2005 |
Nagai H, Cambronne ED, Kagan JC, Amor JC, Kahn RA, Roy CR. A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 826-31. PMID 15613486 DOI: 10.1073/Pnas.0406239101 |
0.71 |
|
| 2005 |
Amor JC, Swails J, Zhu X, Roy CR, Nagai H, Ingmundson A, Cheng X, Kahn RA. The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site. The Journal of Biological Chemistry. 280: 1392-400. PMID 15520000 DOI: 10.1074/Jbc.M410820200 |
0.757 |
|
| 2004 |
Zamboni DS, Campos MA, Torrecilhas AC, Kiss K, Samuel JE, Golenbock DT, Lauw FN, Roy CR, Almeida IC, Gazzinelli RT. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. The Journal of Biological Chemistry. 279: 54405-15. PMID 15485838 DOI: 10.1074/Jbc.M410340200 |
0.631 |
|
| 2004 |
Neild AL, Roy CR. Immunity to vacuolar pathogens: what can we learn from Legionella? Cellular Microbiology. 6: 1011-8. PMID 15469430 DOI: 10.1111/J.1462-5822.2004.00450.X |
0.819 |
|
| 2004 |
Kagan JC, Stein MP, Pypaert M, Roy CR. Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. The Journal of Experimental Medicine. 199: 1201-11. PMID 15117975 DOI: 10.1084/Jem.20031706 |
0.696 |
|
| 2004 |
Guignot J, Caron E, Beuzón C, Bucci C, Kagan J, Roy C, Holden DW. Microtubule motors control membrane dynamics of Salmonella-containing vacuoles. Journal of Cell Science. 117: 1033-45. PMID 14970261 DOI: 10.1242/Jcs.00949 |
0.683 |
|
| 2003 |
Roy CR. Immunology: professional secrets. Nature. 425: 351-2. PMID 14508466 DOI: 10.1038/425351A |
0.401 |
|
| 2003 |
Zamboni DS, McGrath S, Rabinovitch M, Roy CR. Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm system. Molecular Microbiology. 49: 965-76. PMID 12890021 DOI: 10.1046/J.1365-2958.2003.03626.X |
0.778 |
|
| 2003 |
Neild AL, Roy CR. Legionella reveal dendritic cell functions that facilitate selection of antigens for MHC class II presentation. Immunity. 18: 813-23. PMID 12818162 DOI: 10.1016/S1074-7613(03)00140-7 |
0.796 |
|
| 2003 |
Nagai H, Roy CR. Show me the substrates: modulation of host cell function by type IV secretion systems. Cellular Microbiology. 5: 373-83. PMID 12780775 DOI: 10.1046/J.1462-5822.2003.00285.X |
0.431 |
|
| 2003 |
Roy CR, van der Goot FG. Eukaryotic cells and microbial pathogens: a familiar couple take centre stage. Nature Cell Biology. 5: 16-9. PMID 12511887 DOI: 10.1038/Ncb0103-16 |
0.404 |
|
| 2002 |
Kagan JC, Roy CR. Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nature Cell Biology. 4: 945-54. PMID 12447391 DOI: 10.1038/Ncb883 |
0.683 |
|
| 2002 |
Roy CR. Exploitation of the endoplasmic reticulum by bacterial pathogens. Trends in Microbiology. 10: 418-24. PMID 12217507 DOI: 10.1016/S0966-842X(02)02421-6 |
0.483 |
|
| 2002 |
Roy CR, Tilney LG. The road less traveled: transport of Legionella to the endoplasmic reticulum. The Journal of Cell Biology. 158: 415-9. PMID 12147677 DOI: 10.1083/Jcb.200205011 |
0.448 |
|
| 2002 |
Kahn RA, Fu H, Roy CR. Cellular hijacking: a common strategy for microbial infection. Trends in Biochemical Sciences. 27: 308-14. PMID 12069791 DOI: 10.1016/S0968-0004(02)02108-4 |
0.487 |
|
| 2002 |
Roy CR. The Dot/lcm transporter of Legionella pneumophila: a bacterial conductor of vesicle trafficking that orchestrates the establishment of a replicative organelle in eukaryotic hosts. International Journal of Medical Microbiology : Ijmm. 291: 463-7. PMID 11890545 DOI: 10.1078/1438-4221-00154 |
0.506 |
|
| 2002 |
Nagai H, Kagan JC, Zhu X, Kahn RA, Roy CR. A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science (New York, N.Y.). 295: 679-82. PMID 11809974 DOI: 10.1126/Science.1067025 |
0.716 |
|
| 2001 |
Tilney LG, Harb OS, Connelly PS, Robinson CG, Roy CR. How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane. Journal of Cell Science. 114: 4637-50. PMID 11792828 |
0.634 |
|
| 2001 |
Nagai H, Roy CR. The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot/Icm transporter Embo Journal. 20: 5962-5970. PMID 11689436 DOI: 10.1093/Emboj/20.21.5962 |
0.478 |
|
| 2001 |
Roy CR. The Dot/Icm transporter of Legionella pneumophila: A bacterial conductor of vesicle trafficking that orchestrates the establishment of a replicative organelle in eukaryotic hosts International Journal of Medical Microbiology. 291: 463-467. |
0.409 |
|
| 2000 |
Coers J, Kagan JC, Matthews M, Nagai H, Zuckman DM, Roy CR. Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. Molecular Microbiology. 38: 719-36. PMID 11115108 DOI: 10.1046/J.1365-2958.2000.02176.X |
0.778 |
|
| 2000 |
Matthews M, Roy CR. Identification and subcellular localization of the Legionella pneumophila IcmX protein: a factor essential for establishment of a replicative organelle in eukaryotic host cells. Infection and Immunity. 68: 3971-82. PMID 10858211 DOI: 10.1128/Iai.68.7.3971-3982.2000 |
0.711 |
|
| 2000 |
Roy CR, Coers J. Exploitation of macrophages as a replication niche by Legionella pneumophila: Response Trends in Microbiology. 8: 49-50. PMID 10664593 DOI: 10.1016/S0966-842X(99)01673-X |
0.345 |
|
| 1999 |
Coers J, Monahan C, Roy CR. Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth Nature Cell Biology. 1: 451-453. PMID 10559990 DOI: 10.1038/15687 |
0.31 |
|
| 1999 |
Zuckman DM, Hung JB, Roy CR. Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth Molecular Microbiology. 32: 990-1001. PMID 10361301 DOI: 10.1046/J.1365-2958.1999.01410.X |
0.545 |
|
| 1998 |
Roy CR, Berger KH, Isberg RR. Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake. Molecular Microbiology. 28: 663-74. PMID 9632267 DOI: 10.1046/J.1365-2958.1998.00841.X |
0.776 |
|
| 1997 |
Roy CR, Isberg RR. Topology of Legionella pneumophila DotA: an inner membrane protein required for replication in macrophages. Infection and Immunity. 65: 571-8. PMID 9009315 DOI: 10.1128/Iai.65.2.571-578.1997 |
0.736 |
|
| 1993 |
Isberg RR, Rankin S, Roy CR, Swanson MS, Berger KH. Legionella pneumophila: factors involved in the route and response to an intracellular niche. Infectious Agents and Disease. 2: 220-3. PMID 8173798 |
0.718 |
|
| 1991 |
Roy CR, Falkow S. Identification of Bordetella pertussis regulatory sequences required for transcriptional activation of the fhaB gene and autoregulation of the bvgAS operon. Journal of Bacteriology. 173: 2385-92. PMID 2007557 DOI: 10.1128/Jb.173.7.2385-2392.1991 |
0.581 |
|
| 1990 |
Roy CR, Miller JF, Falkow S. Autogenous regulation of the Bordetella pertussis bvgABC operon. Proceedings of the National Academy of Sciences of the United States of America. 87: 3763-7. PMID 2111016 DOI: 10.1073/Pnas.87.10.3763 |
0.575 |
|
| 1989 |
Miller JF, Roy CR, Falkow S. Analysis of Bordetella pertussis virulence gene regulation by use of transcriptional fusions in Escherichia coli. Journal of Bacteriology. 171: 6345-8. PMID 2553678 DOI: 10.1128/Jb.171.11.6345-6348.1989 |
0.591 |
|
| 1989 |
Roy CR, Miller JF, Falkow S. The bvgA gene of Bordetella pertussis encodes a transcriptional activator required for coordinate regulation of several virulence genes. Journal of Bacteriology. 171: 6338-44. PMID 2553677 DOI: 10.1128/Jb.171.11.6338-6344.1989 |
0.598 |
|
| 1989 |
Aricó B, Miller JF, Roy C, Stibitz S, Monack D, Falkow S, Gross R, Rappuoli R. Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proceedings of the National Academy of Sciences of the United States of America. 86: 6671-5. PMID 2549542 DOI: 10.1073/Pnas.86.17.6671 |
0.73 |
|
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