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Kim Lewis - Publications

Affiliations: 
Tufts University, Boston 
Area:
Microbiology Biology
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127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, De Benedetti S, Krueger AM, Vermeulen BJA, Harbig T, Lavore F, Kumar R, Honorato RV, Grein F, Nieselt K, Liu Y, ... ... Lewis K, et al. An antibiotic from an uncultured bacterium binds to an immutable target. Cell. PMID 37611581 DOI: 10.1016/j.cell.2023.07.038  0.336
2023 Chen CW, Leimer N, Syroegin EA, Dunand C, Bulman ZP, Lewis K, Polikanov YS, Svetlov MS. Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A. Nature Communications. 14: 4196. PMID 37452045 DOI: 10.1038/s41467-023-39653-5  0.334
2023 Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, de Benedetti S, Krueger AM, Vermeulen BJA, Lavore F, Honorato RV, Grein F, Bonvin A, Kubitscheck U, Breukink E, Achorn C, ... ... Lewis K, et al. A new antibiotic from an uncultured bacterium binds to an immutable target. Biorxiv : the Preprint Server For Biology. PMID 37292624 DOI: 10.1101/2023.05.15.540765  0.337
2022 Blaskovich MAT, Hansford KA, Butler MS, Ramu S, Kavanagh AM, Jarrad AM, Prasetyoputri A, Pitt ME, Huang JX, Lindahl F, Ziora ZM, Bradford T, Muldoon C, Rajaratnam P, Pelingon R, ... ... Lewis K, et al. A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections. Science Translational Medicine. 14: eabj2381. PMID 36103517 DOI: 10.1126/scitranslmed.abj2381  0.361
2022 Shahsavari N, Wang B, Imai Y, Mori M, Son S, Liang L, Böhringer N, Manuse S, Gates MF, Morrissette M, Corsetti R, Espinoza JL, Dupont CL, Laub MT, Lewis K. A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP. Mbio. e0070022. PMID 35575547 DOI: 10.1128/mbio.00700-22  0.377
2022 Nicolau SE, Lewis K. The Role of Integration Host Factor in Escherichia coli Persister Formation. Mbio. e0342021. PMID 34982597 DOI: 10.1128/mbio.03420-21  0.3
2021 Böhringer N, Green R, Liu Y, Mettal U, Marner M, Modaresi SM, Jakob RP, Wuisan ZG, Maier T, Iinishi A, Hiller S, Lewis K, Schäberle TF. Mutasynthetic Production and Antimicrobial Characterization of Darobactin Analogs. Microbiology Spectrum. 9: e0153521. PMID 34937193 DOI: 10.1128/spectrum.01535-21  0.357
2021 Crüsemann M, Wirtz DA, Ludwig KC, Arts M, Marx CE, Krannich S, Barac P, Kehraus S, Josten M, Henrichfreise B, Müller A, König GM, Peoples AJ, Nitti A, Spoering AL, ... ... Lewis K, et al. Biosynthesis and mechanism of action of the cell wall targeting antibiotic hypeptin. Angewandte Chemie (International Ed. in English). PMID 33768646 DOI: 10.1002/anie.202102224  0.318
2020 Quigley J, Peoples A, Sarybaeva A, Hughes D, Ghiglieri M, Achorn C, Desrosiers A, Felix C, Liang L, Malveira S, Millett W, Nitti A, Tran B, Zullo A, Anklin C, ... ... Lewis K, et al. Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis. Mbio. 11. PMID 32753498 DOI: 10.1128/Mbio.01516-20  0.384
2020 Imai Y, Meyer KJ, Iinishi A, Favre-Godal Q, Green R, Manuse S, Caboni M, Mori M, Niles S, Ghiglieri M, Honrao C, Ma X, Guo JJ, Makriyannis A, Linares-Otoya L, ... ... Lewis K, et al. Author Correction: A new antibiotic selectively kills Gram-negative pathogens. Nature. 580: E3. PMID 32269338 DOI: 10.1038/S41586-020-2063-9  0.365
2020 Lewis K. The Science of Antibiotic Discovery. Cell. PMID 32197064 DOI: 10.1016/J.Cell.2020.02.056  0.423
2020 Morris MA, Malek M, Hashemian MH, Nguyen BT, Manuse S, Lewis K, Nowick JS. A Fluorescent Teixobactin Analogue. Acs Chemical Biology. PMID 32045203 DOI: 10.1021/Acschembio.9B00908  0.362
2020 O'Rourke A, Beyhan S, Choi Y, Morales P, Chan AP, Espinoza JL, Dupont CL, Meyer KJ, Spoering A, Lewis K, Nierman WC, Nelson KE. Mechanism-Of-Action Classification of Antibiotics by Global Transcriptome Profiling. Antimicrobial Agents and Chemotherapy. PMID 31907190 DOI: 10.1128/Aac.01207-19  0.418
2019 Imai Y, Meyer KJ, Iinishi A, Favre-Godal Q, Green R, Manuse S, Caboni M, Mori M, Niles S, Ghiglieri M, Honrao C, Ma X, Guo J, Makriyannis A, Linares-Otoya L, ... ... Lewis K, et al. A new antibiotic selectively kills Gram-negative pathogens. Nature. PMID 31747680 DOI: 10.1038/S41586-019-1791-1  0.489
2019 O'Connor K, Morrissette M, Strandwitz P, Ghiglieri M, Caboni M, Liu H, Khoo C, D'Onofrio A, Lewis K. Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model. Plos One. 14: e0224836. PMID 31714906 DOI: 10.1371/Journal.Pone.0224836  0.415
2019 Zalis EA, Nuxoll AS, Manuse S, Clair G, Radlinski LC, Conlon BP, Adkins J, Lewis K. Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells. Mbio. 10. PMID 31530676 DOI: 10.1128/Mbio.01930-19  0.447
2019 Zong Y, Fang F, Meyer KJ, Wang L, Ni Z, Gao H, Lewis K, Zhang J, Rao Y. Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics. Nature Communications. 10: 3268. PMID 31332172 DOI: 10.1038/S41467-019-11211-Y  0.427
2019 Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, et al. Definitions and guidelines for research on antibiotic persistence. Nature Reviews. Microbiology. PMID 30980069 DOI: 10.1038/S41579-019-0196-3  0.448
2018 Wu X, Sharma B, Niles S, O'Connor K, Schilling R, Matluck N, D'Onofrio A, Hu LT, Lewis K. Identifying vancomycin as an effective antibiotic for killing . Antimicrobial Agents and Chemotherapy. PMID 30126963 DOI: 10.1128/Aac.01201-18  0.44
2018 Cameron DR, Shan Y, Zalis EA, Isabella V, Lewis K. A genetic determinant of persister cell formation in bacterial pathogens. Journal of Bacteriology. PMID 29941425 DOI: 10.1128/Jb.00303-18  0.442
2018 Zong Y, Sun X, Gao H, Meyer KJ, Lewis K, Rao Y. Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin. Journal of Medicinal Chemistry. PMID 29629769 DOI: 10.1021/Acs.Jmedchem.7B01241  0.342
2017 Fenn K, Strandwitz P, Stewart EJ, Dimise E, Rubin S, Gurubacharya S, Clardy J, Lewis K. Quinones are growth factors for the human gut microbiota. Microbiome. 5: 161. PMID 29262868 DOI: 10.1186/S40168-017-0380-5  0.32
2017 Lewis K, Caboni M. The Making of a Pathogen. Cell Host & Microbe. 21: 653-654. PMID 28618261 DOI: 10.1016/J.Chom.2017.06.001  0.355
2017 Lewis K, Shan Y. Why tolerance invites resistance. Science (New York, N.Y.). 355: 796. PMID 28232537 DOI: 10.1126/Science.Aam7926  0.451
2017 Shan Y, Brown Gandt A, Rowe SE, Deisinger JP, Conlon BP, Lewis K. ATP-Dependent Persister Formation in Escherichia coli. Mbio. 8. PMID 28174313 DOI: 10.1128/Mbio.02267-16  0.391
2016 Jones MB, Nierman WC, Shan Y, Frank BC, Spoering A, Ling L, Peoples A, Zullo A, Lewis K, Nelson KE. Reducing the Bottleneck in Discovery of Novel Antibiotics. Microbial Ecology. PMID 27896376 DOI: 10.1007/S00248-016-0889-3  0.365
2016 Lewis K. New Approaches to Antimicrobial Discovery. Biochemical Pharmacology. PMID 27823963 DOI: 10.1016/J.Bcp.2016.11.002  0.447
2016 Conlon BP, Rowe SE, Gandt AB, Nuxoll AS, Donegan NP, Zalis EA, Clair G, Adkins JN, Cheung AL, Lewis K. Persister formation in Staphylococcus aureus is associated with ATP depletion. Nature Microbiology. 1: 16051. PMID 27572649 DOI: 10.1038/Nmicrobiol.2016.51  0.464
2016 Homma T, Nuxoll A, Brown Gandt A, Ebner P, Engels I, Schneider T, Götz F, Lewis K, Conlon BP. Dual targeting of cell wall precursors by teixobactin leads to cell lysis. Antimicrobial Agents and Chemotherapy. PMID 27550357 DOI: 10.1128/Aac.01050-16  0.429
2016 Lewis K, Strandwitz P. Microbiology: Antibiotics right under our nose. Nature. 535: 501-2. PMID 27466121 DOI: 10.1038/535501A  0.464
2016 Conlon BP, Rowe SE, Gandt AB, Nuxoll AS, Donegan NP, Zalis EA, Clair G, Adkins JN, Cheung AL, Lewis K. Persister formation in Staphylococcus aureus is associated with ATP depletion. Nature Microbiology. 1. PMID 27398229 DOI: 10.1038/nmicrobiol.2016.51  0.362
2016 Torrey HL, Keren I, Via LE, Lee JS, Lewis K. High Persister Mutants in Mycobacterium tuberculosis. Plos One. 11: e0155127. PMID 27176494 DOI: 10.1371/Journal.Pone.0155127  0.38
2016 Rowe SE, Conlon BP, Keren I, Lewis K. Persisters: Methods for Isolation and Identifying Contributing Factors-A Review. Methods in Molecular Biology (Clifton, N.J.). 1333: 17-28. PMID 26468096 DOI: 10.1007/978-1-4939-2854-5_2  0.356
2015 Dolla NK, Chen C, Larkins-Ford J, Rajamuthiah R, Jagadeesan S, Conery AL, Ausubel FM, Mylonakis E, Bremner JB, Lewis K, Kelso MJ. On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials. Australian Journal of Chemistry. 67: 1471-1480. PMID 26806960 DOI: 10.1071/Ch14426  0.39
2015 Schumacher MA, Balani P, Min J, Chinnam NB, Hansen S, Vulić M, Lewis K, Brennan RG. HipBA-promoter structures reveal the basis of heritable multidrug tolerance. Nature. 524: 59-64. PMID 26222023 DOI: 10.1038/Nature14662  0.394
2015 Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K. Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells. Antimicrobial Agents and Chemotherapy. 59: 4616-24. PMID 26014929 DOI: 10.1128/Aac.00864-15  0.432
2015 Shan Y, Lazinski D, Rowe S, Camilli A, Lewis K. Genetic basis of persister tolerance to aminoglycosides in Escherichia coli. Mbio. 6. PMID 25852159 DOI: 10.1128/Mbio.00078-15  0.335
2015 Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, ... ... Lewis K, et al. Erratum: A new antibiotic kills pathogens without detectable resistance. Nature. 520: 388. PMID 25731174 DOI: 10.1038/Nature14303  0.348
2015 Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, ... ... Lewis K, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 517: 455-9. PMID 25561178 DOI: 10.1038/Nature14098  0.482
2015 Conlon BP, Rowe SE, Lewis K. Persister cells in biofilm associated infections. Advances in Experimental Medicine and Biology. 831: 1-9. PMID 25384659 DOI: 10.1007/978-3-319-09782-4_1  0.415
2015 Lewis K. Challenges of antibiotic discovery: Antibiotic resistance and tolerance plus troubles with discovery platforms complicate efforts to identify useful antibacterial drug candidates Microbe. 10: 363-369. DOI: 10.1128/Microbe.10.363.1  0.463
2014 Gavrish E, Shrestha B, Chen C, Lister I, North EJ, Yang L, Lee RE, Han A, Williams B, Charnuska D, Coleman K, Lewis K, LaFleur MD. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrobial Agents and Chemotherapy. 58: 3255-60. PMID 24687512 DOI: 10.1128/Aac.02573-13  0.318
2014 Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, ... ... Lewis K, et al. Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chemistry & Biology. 21: 509-18. PMID 24684906 DOI: 10.1016/J.Chembiol.2014.01.014  0.412
2014 Chen C, Dolla NK, Casadei G, Bremner JB, Lewis K, Kelso MJ. Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. Bioorganic & Medicinal Chemistry Letters. 24: 595-600. PMID 24360560 DOI: 10.1016/J.Bmcl.2013.12.015  0.362
2014 Fleck LE, North EJ, Lee RE, Mulcahy LR, Casadei G, Lewis K. A screen for and validation of prodrug antimicrobials. Antimicrobial Agents and Chemotherapy. 58: 1410-9. PMID 24342644 DOI: 10.1128/Aac.02136-13  0.447
2014 Mulcahy LR, Isabella VM, Lewis K. Pseudomonas aeruginosa biofilms in disease. Microbial Ecology. 68: 1-12. PMID 24096885 DOI: 10.1007/S00248-013-0297-X  0.412
2013 Conlon BP, Nakayasu ES, Fleck LE, LaFleur MD, Isabella VM, Coleman K, Leonard SN, Smith RD, Adkins JN, Lewis K. Activated ClpP kills persisters and eradicates a chronic biofilm infection. Nature. 503: 365-70. PMID 24226776 DOI: 10.1038/Nature12790  0.443
2013 Theodore A, Lewis K, Vulic M. Tolerance of Escherichia coli to fluoroquinolone antibiotics depends on specific components of the SOS response pathway. Genetics. 195: 1265-76. PMID 24077306 DOI: 10.1534/Genetics.113.152306  0.383
2013 Balaban NQ, Gerdes K, Lewis K, McKinney JD. A problem of persistence: still more questions than answers? Nature Reviews. Microbiology. 11: 587-91. PMID 24020075 DOI: 10.1038/Nrmicro3076  0.451
2013 Lafleur MD, Sun L, Lister I, Keating J, Nantel A, Long L, Ghannoum M, North J, Lee RE, Coleman K, Dahl T, Lewis K. Potentiation of azole antifungals by 2-adamantanamine. Antimicrobial Agents and Chemotherapy. 57: 3585-92. PMID 23689724 DOI: 10.1128/Aac.00294-13  0.387
2013 Lewis K. Platforms for antibiotic discovery. Nature Reviews. Drug Discovery. 12: 371-87. PMID 23629505 DOI: 10.1038/Nrd3975  0.463
2013 Keren I, Wu Y, Inocencio J, Mulcahy LR, Lewis K. Killing by bactericidal antibiotics does not depend on reactive oxygen species. Science (New York, N.Y.). 339: 1213-6. PMID 23471410 DOI: 10.1126/Science.1232688  0.416
2012 Lewis K. Persister cells: molecular mechanisms related to antibiotic tolerance. Handbook of Experimental Pharmacology. 121-33. PMID 23090599 DOI: 10.1007/978-3-642-28951-4_8  0.466
2012 Keren I, Mulcahy LR, Lewis K. Persister eradication: lessons from the world of natural products. Methods in Enzymology. 517: 387-406. PMID 23084949 DOI: 10.1016/B978-0-12-404634-4.00019-X  0.472
2012 Lechner S, Lewis K, Bertram R. Staphylococcus aureus persisters tolerant to bactericidal antibiotics. Journal of Molecular Microbiology and Biotechnology. 22: 235-44. PMID 22986269 DOI: 10.1159/000342449  0.425
2012 Wu Y, Vulić M, Keren I, Lewis K. Role of oxidative stress in persister tolerance. Antimicrobial Agents and Chemotherapy. 56: 4922-6. PMID 22777047 DOI: 10.1128/Aac.00921-12  0.414
2012 Hansen S, Vulić M, Min J, Yen TJ, Schumacher MA, Brennan RG, Lewis K. Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. Plos One. 7: e39185. PMID 22720069 DOI: 10.1371/Journal.Pone.0039185  0.356
2012 Lewis K. Antibiotics: Recover the lost art of drug discovery. Nature. 485: 439-40. PMID 22622552 DOI: 10.1038/485439A  0.384
2011 Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerner SA, Levy S, Lewis K, Lomovskaya O, Miller JH, et al. Tackling antibiotic resistance. Nature Reviews. Microbiology. 9: 894-6. PMID 22048738 DOI: 10.1038/Nrmicro2693  0.417
2011 Keren I, Minami S, Rubin E, Lewis K. Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters. Mbio. 2: e00100-11. PMID 21673191 DOI: 10.1128/Mbio.00100-11  0.364
2011 Fiamegos YC, Kastritis PL, Exarchou V, Han H, Bonvin AM, Vervoort J, Lewis K, Hamblin MR, Tegos GP. Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria. Plos One. 6: e18127. PMID 21483731 DOI: 10.1371/Journal.Pone.0018127  0.451
2011 LaFleur MD, Lucumi E, Napper AD, Diamond SL, Lewis K. Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms. The Journal of Antimicrobial Chemotherapy. 66: 820-6. PMID 21393183 DOI: 10.1093/Jac/Dkq530  0.399
2011 Gurnev PA, Ortenberg R, Lewis K, Bezrukov SM. Protective Bacterial Toxin TisB Produces Well-Defined Anion-Selective Pores in Planar Lipid Bilayers Biophysical Journal. 100: 3-6. DOI: 10.1016/J.Bpj.2010.12.2041  0.302
2010 Mulcahy LR, Burns JL, Lory S, Lewis K. Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. Journal of Bacteriology. 192: 6191-9. PMID 20935098 DOI: 10.1128/Jb.01651-09  0.421
2010 Bollmann A, Palumbo AV, Lewis K, Epstein SS. Isolation and physiology of bacteria from contaminated subsurface sediments. Applied and Environmental Microbiology. 76: 7413-9. PMID 20870785 DOI: 10.1128/Aem.00376-10  0.323
2010 Lewis K, Epstein S, D'Onofrio A, Ling LL. Uncultured microorganisms as a source of secondary metabolites. The Journal of Antibiotics. 63: 468-76. PMID 20648021 DOI: 10.1038/Ja.2010.87  0.335
2010 Lewis K. Persister cells. Annual Review of Microbiology. 64: 357-72. PMID 20528688 DOI: 10.1146/annurev.micro.112408.134306  0.318
2010 Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner J, Bremner JB, Ausubel FM, Lewis K, Kelso MJ. Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. Antimicrobial Agents and Chemotherapy. 54: 3219-24. PMID 20498327 DOI: 10.1128/Aac.01715-09  0.394
2010 D'Onofrio A, Crawford JM, Stewart EJ, Witt K, Gavrish E, Epstein S, Clardy J, Lewis K. Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chemistry & Biology. 17: 254-64. PMID 20338517 DOI: 10.1016/J.Chembiol.2010.02.010  0.347
2010 Dörr T, Vulić M, Lewis K. Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. Plos Biology. 8: e1000317. PMID 20186264 DOI: 10.1371/Journal.Pbio.1000317  0.416
2010 Nichols D, Cahoon N, Trakhtenberg EM, Pham L, Mehta A, Belanger A, Kanigan T, Lewis K, Epstein SS. Use of ichip for high-throughput in situ cultivation of "uncultivable" microbial species. Applied and Environmental Microbiology. 76: 2445-50. PMID 20173072 DOI: 10.1128/Aem.01754-09  0.324
2010 Lafleur MD, Qi Q, Lewis K. Patients with long-term oral carriage harbor high-persister mutants of Candida albicans. Antimicrobial Agents and Chemotherapy. 54: 39-44. PMID 19841146 DOI: 10.1128/Aac.00860-09  0.389
2010 Lewis K. Persister cells and the paradox of chronic infections Microbe. 5: 429-437. DOI: 10.1128/Microbe.5.429.1  0.361
2009 Dörr T, Lewis K, Vulić M. SOS response induces persistence to fluoroquinolones in Escherichia coli. Plos Genetics. 5: e1000760. PMID 20011100 DOI: 10.1371/Journal.Pgen.1000760  0.433
2009 Moy TI, Conery AL, Larkins-Ford J, Wu G, Mazitschek R, Casadei G, Lewis K, Carpenter AE, Ausubel FM. High-throughput screen for novel antimicrobials using a whole animal infection model. Acs Chemical Biology. 4: 527-33. PMID 19572548 DOI: 10.1021/Cb900084V  0.36
2009 Samosorn S, Tanwirat B, Muhamad N, Casadei G, Tomkiewicz D, Lewis K, Suksamrarn A, Prammananan T, Gornall KC, Beck JL, Bremner JB. Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. Bioorganic & Medicinal Chemistry. 17: 3866-72. PMID 19419877 DOI: 10.1016/J.Bmc.2009.04.028  0.328
2009 Schumacher MA, Piro KM, Xu W, Hansen S, Lewis K, Brennan RG. Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science (New York, N.Y.). 323: 396-401. PMID 19150849 DOI: 10.1126/Science.1163806  0.344
2008 Hansen S, Lewis K, Vulić M. Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Antimicrobial Agents and Chemotherapy. 52: 2718-26. PMID 18519731 DOI: 10.1128/Aac.00144-08  0.406
2008 Nichols D, Lewis K, Orjala J, Mo S, Ortenberg R, O'Connor P, Zhao C, Vouros P, Kaeberlein T, Epstein SS. Short peptide induces an "uncultivable" microorganism to grow in vitro. Applied and Environmental Microbiology. 74: 4889-97. PMID 18515474 DOI: 10.1128/Aem.00393-08  0.319
2008 Lewis K. Multidrug tolerance of biofilms and persister cells Current Topics in Microbiology and Immunology. 322: 107-131. PMID 18453274 DOI: 10.1007/978-3-540-75418-3_6  0.491
2008 Lewis K, Epstein S, Godoy VG, Hong SH. Intact DNA in ancient permafrost. Trends in Microbiology. 16: 92-4. PMID 18291656 DOI: 10.1016/J.Tim.2008.01.002  0.307
2008 Gavrish E, Bollmann A, Epstein S, Lewis K. A trap for in situ cultivation of filamentous actinobacteria. Journal of Microbiological Methods. 72: 257-62. PMID 18255181 DOI: 10.1016/J.Mimet.2007.12.009  0.312
2007 Lewis K. Persister cells, dormancy and infectious disease. Nature Reviews. Microbiology. 5: 48-56. PMID 17143318 DOI: 10.1038/Nrmicro1557  0.417
2006 Ball AR, Casadei G, Samosorn S, Bremner JB, Ausubel FM, Moy TI, Lewis K. Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial. Acs Chemical Biology. 1: 594-600. PMID 17168555 DOI: 10.1021/Cb600238X  0.473
2006 Correia FF, D'Onofrio A, Rejtar T, Li L, Karger BL, Makarova K, Koonin EV, Lewis K. Kinase activity of overexpressed HipA is required for growth arrest and multidrug tolerance in Escherichia coli. Journal of Bacteriology. 188: 8360-7. PMID 17041039 DOI: 10.1128/Jb.01237-06  0.342
2006 LaFleur MD, Kumamoto CA, Lewis K. Candida albicans biofilms produce antifungal-tolerant persister cells. Antimicrobial Agents and Chemotherapy. 50: 3839-46. PMID 16923951 DOI: 10.1128/Aac.00684-06  0.46
2006 Spoering AL, Vulic M, Lewis K. GlpD and PlsB participate in persister cell formation in Escherichia coli. Journal of Bacteriology. 188: 5136-44. PMID 16816185 DOI: 10.1128/Jb.00369-06  0.428
2006 Moy TI, Ball AR, Anklesaria Z, Casadei G, Lewis K, Ausubel FM. Identification of novel antimicrobials using a live-animal infection model. Proceedings of the National Academy of Sciences of the United States of America. 103: 10414-9. PMID 16801562 DOI: 10.1073/Pnas.0604055103  0.421
2006 Shah D, Zhang Z, Khodursky A, Kaldalu N, Kurg K, Lewis K. Persisters: a distinct physiological state of E. coli. Bmc Microbiology. 6: 53. PMID 16768798 DOI: 10.1186/1471-2180-6-53  0.431
2006 Belofsky G, Carreno R, Lewis K, Ball A, Casadei G, Tegos GP. Metabolites of the "smoke tree", Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus. Journal of Natural Products. 69: 261-4. PMID 16499327 DOI: 10.1021/Np058057S  0.439
2006 Samosorn S, Bremner JB, Ball A, Lewis K. Synthesis of functionalized 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors. Bioorganic & Medicinal Chemistry. 14: 857-65. PMID 16203150 DOI: 10.1016/J.Bmc.2005.09.019  0.374
2005 Lewis K, Klibanov AM. Surpassing nature: rational design of sterile-surface materials. Trends in Biotechnology. 23: 343-8. PMID 15922467 DOI: 10.1016/J.Tibtech.2005.05.004  0.367
2005 Milović NM, Wang J, Lewis K, Klibanov AM. Immobilized N-alkylated polyethylenimine avidly kills bacteria by rupturing cell membranes with no resistance developed. Biotechnology and Bioengineering. 90: 715-22. PMID 15803464 DOI: 10.1002/Bit.20454  0.422
2005 Lewis K. Persister cells and the riddle of biofilm survival Biokhimiya. 70: 327-336. DOI: 10.1007/S10541-005-0111-6  0.446
2005 Lewis K. Persister cells and the riddle of biofilm survival Biokhimiya. 70: 327-336. DOI: 10.1007/s10541-005-0111-6  0.343
2004 Keren I, Shah D, Spoering A, Kaldalu N, Lewis K. Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. Journal of Bacteriology. 186: 8172-80. PMID 15576765 DOI: 10.1128/Jb.186.24.8172-8180.2004  0.435
2004 Belofsky G, Percivill D, Lewis K, Tegos GP, Ekart J. Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria. Journal of Natural Products. 67: 481-4. PMID 15043439 DOI: 10.1021/Np030409C  0.419
2004 Kaldalu N, Mei R, Lewis K. Killing by ampicillin and ofloxacin induces overlapping changes in Escherichia coli transcription profile. Antimicrobial Agents and Chemotherapy. 48: 890-6. PMID 14982780 DOI: 10.1128/Aac.48.3.890-896.2004  0.375
2004 Keren I, Kaldalu N, Spoering A, Wang Y, Lewis K. Persister cells and tolerance to antimicrobials. Fems Microbiology Letters. 230: 13-8. PMID 14734160 DOI: 10.1016/S0378-1097(03)00856-5  0.546
2004 Keren I, Kaldalu N, Spoering A, Wang Y, Lewis K. Corrigendum to: “Persister cells and tolerance to antimicrobials” [FEMS Microbiol. Lett. 230 (2003) 12–18] Fems Microbiology Letters. 234: 187-187. DOI: 10.1111/J.1574-6968.2004.Tb09532.X  0.403
2003 Morel C, Stermitz FR, Tegos G, Lewis K. Isoflavones as potentiators of antibacterial activity. Journal of Agricultural and Food Chemistry. 51: 5677-9. PMID 12952418 DOI: 10.1021/Jf0302714  0.411
2003 Lin J, Qiu S, Lewis K, Klibanov AM. Mechanism of bactericidal and fungicidal activities of textiles covalently modified with alkylated polyethylenimine. Biotechnology and Bioengineering. 83: 168-72. PMID 12768622 DOI: 10.1002/Bit.10651  0.349
2003 Stermitz FR, Cashman KK, Halligan KM, Morel C, Tegos GP, Lewis K. Polyacylated neohesperidosides from Geranium caespitosum: bacterial multidrug resistance pump inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 1915-8. PMID 12749897 DOI: 10.1016/S0960-894X(03)00316-0  0.44
2002 Stermitz FR, Scriven LN, Tegos G, Lewis K. Two flavonols from Artemisa annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus. Planta Medica. 68: 1140-1. PMID 12494348 DOI: 10.1055/S-2002-36347  0.411
2002 Tegos G, Stermitz FR, Lomovskaya O, Lewis K. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrobial Agents and Chemotherapy. 46: 3133-41. PMID 12234835 DOI: 10.1128/Aac.46.10.3133-3141.2002  0.425
2002 Kaeberlein T, Lewis K, Epstein SS. Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment. Science (New York, N.Y.). 296: 1127-9. PMID 12004133 DOI: 10.1126/Science.1070633  0.347
2002 Lin J, Tiller JC, Lee SB, Lewis K, Klibanov AM. Insights into bactericidal action of surface-attached poly(vinyl-N-hexylpyridinium) chains Biotechnology Letters. 24: 801-805. DOI: 10.1023/A:1015584423358  0.378
2001 Spoering AL, Lewis K. Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials. Journal of Bacteriology. 183: 6746-6751. PMID 11698361 DOI: 10.1128/Jb.183.23.6746-6751.2001  0.436
2001 Stermitz FR, Beeson TD, Mueller PJ, Hsiang J, Lewis K. Staphylococcus aureus MDR efflux pump inhibitors from a Berberis and a Mahonia (sensu strictu) species. Biochemical Systematics and Ecology. 29: 793-798. PMID 11412952 DOI: 10.1016/S0305-1978(01)00025-4  0.38
2001 Tiller JC, Liao CJ, Lewis K, Klibanov AM. Designing surfaces that kill bacteria on contact. Proceedings of the National Academy of Sciences of the United States of America. 98: 5981-5. PMID 11353851 DOI: 10.1073/Pnas.111143098  0.37
2001 Lewis K. Riddle of biofilm resistance Antimicrobial Agents and Chemotherapy. 45: 999-1007. PMID 11257008 DOI: 10.1128/Aac.45.4.999-1007.2001  0.472
2001 Guz NR, Stermitz FR, Johnson JB, Beeson TD, Willen S, Hsiang J, Lewis K. Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. Journal of Medicinal Chemistry. 44: 261-8. PMID 11170636 DOI: 10.1021/Jm0004190  0.36
2001 Lewis K, Salyers A, Taber H, Wax R. Bacterial resistance to antimicrobials. South African Medical Journal. 43: 26-30. DOI: 10.1201/9780824744939  0.403
2000 Lewis K. Translocases: A bacterial tunnel for drugs and proteins Current Biology. 10. PMID 10996810 DOI: 10.1016/S0960-9822(00)00682-5  0.333
2000 Stermitz FR, Tawara-Matsuda J, Lorenz P, Mueller P, Zenewicz L, Lewis K. 5'-Methoxyhydnocarpin-D and pheophorbide A: Berberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus. Journal of Natural Products. 63: 1146-9. PMID 10978214 DOI: 10.1021/Np990639K  0.43
2000 Lewis K. Programmed death in bacteria Microbiology and Molecular Biology Reviews. 64: 503-514. PMID 10974124 DOI: 10.1128/Mmbr.64.3.503-514.2000  0.414
2000 Brooun A, Liu S, Lewis K. A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy. 44: 640-6. PMID 10681331 DOI: 10.1128/Aac.44.3.640-646.2000  0.471
2000 Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 97: 1433-7. PMID 10677479 DOI: 10.1073/Pnas.030540597  0.424
2000 Arredondo AR, Dorval BL, Klibanov AM, Lewis K. Rapid immunodetection of Escherichia coli Biotechnology Letters. 22: 547-550. DOI: 10.1023/A:1005616523897  0.309
1999 Lewis K. Multidrug resistance: Versatile drug sensors of bacterial cells Current Biology. 9. PMID 10359693 DOI: 10.1016/S0960-9822(99)80254-1  0.338
1998 Lewis K. Pathogen resistance as the origin of kin altruism Journal of Theoretical Biology. 193: 359-363. PMID 9714935 DOI: 10.1006/Jtbi.1998.0725  0.407
1998 Hsieh PC, Siegel SA, Rogers B, Davis D, Lewis K. Bacteria lacking a multidrug pump: a sensitive tool for drug discovery. Proceedings of the National Academy of Sciences of the United States of America. 95: 6602-6. PMID 9618458 DOI: 10.1073/Pnas.95.12.6602  0.406
1997 Zhang Y, Lewis K. Fabatins: new antimicrobial plant peptides. Fems Microbiology Letters. 149: 59-64. PMID 9103978 DOI: 10.1111/J.1574-6968.1997.Tb10308.X  0.301
1995 Ferrante AA, Augliera J, Lewis K, Klibanov AM. Cloning of an organic solvent-resistance gene in Escherichia coli: The unexpected role of alkylhydroperoxide reductase Proceedings of the National Academy of Sciences of the United States of America. 92: 7617-7621. PMID 7644465 DOI: 10.1073/Pnas.92.17.7617  0.386
1994 Lewis K. Multidrug resistance pumps in bacteria: variations on a theme Trends in Biochemical Sciences. 19: 119-123. PMID 8203018 DOI: 10.1016/0968-0004(94)90204-6  0.406
1994 Lewis K, Naroditskaya V, Ferrante A, Fokina I. Bacterial Resistance To Uncouplers Journal of Bioenergetics and Biomembranes. 26: 639-646. PMID 7721726 DOI: 10.1007/Bf00831539  0.4
1992 Lomovskaya O, Lewis K. Emr, an Escherichia coli locus for multidrug resistance. Proceedings of the National Academy of Sciences of the United States of America. 89: 8938-42. PMID 1409590 DOI: 10.1073/Pnas.89.19.8938  0.391
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