Natasha K. Hussain, Ph.D. - Related publications

Massachusetts Institute of Technology, Cambridge, MA, United States 
molecular neuroscience
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Tran T, Mitra J, Ha T, Kavran JM. Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling. The Journal of Biological Chemistry. PMID 32994222 DOI: 10.1074/jbc.RA120.015723   
2020 Creamer TP. Calcineurin. Cell Communication and Signaling : Ccs. 18: 137. PMID 32859215 DOI: 10.1186/s12964-020-00636-4   
2020 Brian BF, Guerrero CR, Freedman TS. Immunopharmacology and Quantitative Analysis of Tyrosine Kinase Signaling. Current Protocols in Immunology. 130: e104. PMID 32931655 DOI: 10.1002/cpim.104   
2020 Pakharukova N, Masoudi A, Pani B, Staus DP, Lefkowitz RJ. Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. The Journal of Biological Chemistry. PMID 32978252 DOI: 10.1074/jbc.RA120.015400   
2020 Zaoui K, Smith HW, Park M, Duhamel S. ARF6 controls RHOB targeting to endosomes regulating cancer cell invasion. Molecular & Cellular Oncology. 7: 1766932. PMID 32944628 DOI: 10.1080/23723556.2020.1766932   
2020 Gladulich LFH, Xie J, Jensen KB, Kamei M, Paes-de-Carvalho R, Cossenza M, Proud CG. Bicuculline regulated protein synthesis is dependent on homer1 and promotes its interaction with eEF2K through mTORC1 dependent phosphorylation. Journal of Neurochemistry. PMID 32892352 DOI: 10.1111/jnc.15178   
2020 Su Y, Wang X, Guo Z, Wang J. Aberrant JmjC domain-containing protein 8 (JMJD8) expression promotes activation of AKT and tumor epithelial-mesenchymal transition. Oncogene. PMID 32879443 DOI: 10.1038/s41388-020-01446-1   
2020 Seiffert P, Bugge K, Nygaard M, Haxholm GW, Martinsen JH, Pedersen MN, Arleth L, Boomsma W, Kragelund BB. Orchestration of signaling by structural disorder in class 1 cytokine receptors. Cell Communication and Signaling : Ccs. 18: 132. PMID 32831102 DOI: 10.1186/s12964-020-00626-6   
2020 Sun Z, Song Y, Chen D, Zang Y, Zhang Q, Yi Y, Qu G. Genome-Wide Identification, Classification, Characterization, and Expression Analysis of the Wall-Associated Kinase Family during Fruit Development and under Wound Stress in Tomato ( L.). Genes. 11. PMID 33053790 DOI: 10.3390/genes11101186   
2020 Kim PR, Zhang S, Rahmat MB, Koh CG. Partners in crime: POPX2 phosphatase and its interacting proteins in cancer. Cell Death & Disease. 11: 840. PMID 33037179 DOI: 10.1038/s41419-020-03061-0   
2020 Sharma DK, Bihani SC, Siddiqui MQ, Misra HS, Rajpurohit YS. WD40 domain of RqkA regulates its kinase activity and role in extraordinary radioresistance of . Journal of Biomolecular Structure & Dynamics. 1-14. PMID 32990194 DOI: 10.1080/07391102.2020.1824810   
2020 Sieng M, Selvia AF, Garland-Kuntz EE, Hopkins JB, Fisher IJ, Marti AT, Lyon AM. Functional and structural characterization of allosteric activation of Phospholipase Cε by Rap1A. The Journal of Biological Chemistry. PMID 32948655 DOI: 10.1074/jbc.RA120.015685   
2020 Gaviraghi M, Rabellino A, Andolfo A, Brand M, Brombin C, Bagnato P, De Feudis G, Raimondi A, Locatelli A, Tosoni D, Mazza D, Gianni L, Tonon G, Yarden Y, Tacchetti C, et al. Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr phosphorylation. Scientific Reports. 10: 16906. PMID 33037285 DOI: 10.1038/s41598-020-73835-1   
2020 Hu B, Zhang Y, Deng T, Gu J, Liu J, Yang H, Xu Y, Yan Y, Yang F, Zhang H, Jin Y, Zhou J. PDPK1 regulates autophagosome biogenesis by binding to PIK3C3. Autophagy. PMID 32876514 DOI: 10.1080/15548627.2020.1817279   
2020 Dhanaraman T, Singh S, Killoran RC, Singh A, Xu X, Shifman JM, Smith MJ. RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway. Science Signaling. 13. PMID 33051258 DOI: 10.1126/scisignal.abb4778   
2020 Niederkorn M, Agarwal P, Starczynowski DT. TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease. Experimental Hematology. PMID 32910997 DOI: 10.1016/j.exphem.2020.08.010   
2020 Gonzalez-Magaldi M, McCabe JM, Cartwright HN, Sun N, Leahy DJ. Conserved Roles for Receptor Tyrosine Kinase Extracellular Regions in Regulating Receptor and Pathway Activity. The Biochemical Journal. PMID 33043983 DOI: 10.1042/BCJ20200702   
2020 Lin Z, Xie R, Guan K, Zhang M. A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling. Cell Reports. 32: 108118. PMID 32905778 DOI: 10.1016/j.celrep.2020.108118   
2020 Takeuchi T, Lin YT, Fekaris N, Umen JG, Sears BB, Benning C. Modulation of CHT7 complexes during light/dark- and nitrogen-mediated life-cycle transitions of Chlamydomonas. Plant Physiology. PMID 33004613 DOI: 10.1104/pp.20.00864   
2020 Dwivedi-Agnihotri H, Chaturvedi M, Baidya M, Stepniewski TM, Pandey S, Maharana J, Srivastava A, Caengprasath N, Hanyaloglu AC, Selent J, Shukla AK. Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling. Science Advances. 6. PMID 32917711 DOI: 10.1126/sciadv.abb8368   
2020 Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J. An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice. Nature Chemical Biology. PMID 32989297 DOI: 10.1038/s41589-020-00660-y   
2020 Sade N, Weng F, Tajima H, Zeron Y, Zhang L, Rubio Wilhelmi MDM, Day G, Peleg Z, Blumwald E. A Cytoplasmic Receptor-like Kinase Contributes to Salinity Tolerance. Plants (Basel, Switzerland). 9. PMID 33080797 DOI: 10.3390/plants9101383   
2020 Elzwawi A, Grafton G, Barnes NM, Mehellou Y. SPAK and OSR1 kinases bind and phosphorylate the β-Adrenergic receptor. Biochemical and Biophysical Research Communications. 532: 88-93. PMID 32828531 DOI: 10.1016/j.bbrc.2020.07.143   
2020 Melick CH, Jewell JL. Regulation of mTORC1 by Upstream Stimuli. Genes. 11. PMID 32854217 DOI: 10.3390/genes11090989   
2020 Obsilova V, Obsil T. A new role for 14-3-3 protein in steroidogenesis. The Febs Journal. PMID 32852115 DOI: 10.1111/febs.15507   
2020 Ye X, Vogt MS, van der Does C, Bildl W, Schulte U, Essen LO, Albers SV. The Phosphatase PP2A Interacts With ArnA and ArnB to Regulate the Oligomeric State and the Stability of the ArnA/B Complex. Frontiers in Microbiology. 11: 1849. PMID 32973695 DOI: 10.3389/fmicb.2020.01849   
2020 Stein V, Blank-Landeshammer B, Müntjes K, Märker R, Teichert I, Feldbrügge M, Sickmann A, Kück U. The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes. Plos Genetics. 16: e1008819. PMID 32997654 DOI: 10.1371/journal.pgen.1008819   
2020 Zhao L, Geng T, Sun K, Su S, Zhao Y, Bao N, Pan L, Sun H, Li M. Proteomic analysis reveals the molecular mechanism of Hippophae rhamnoides polysaccharide intervention in LPS-induced inflammation of IPEC-J2 cells in piglets. International Journal of Biological Macromolecules. PMID 32888998 DOI: 10.1016/j.ijbiomac.2020.08.235   
2020 Cook SJ, Tucker JA, Lochhead PA. Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for…. Biochemical Society Transactions. PMID 32915196 DOI: 10.1042/BST20190338   
2020 Xu X, Lemmens LJM, den Hamer A, Merkx M, Ottmann C, Brunsveld L. Modular bioengineered kinase sensors scaffold protein-mediated split-luciferase complementation. Chemical Science. 11: 5532-5536. PMID 32874496 DOI: 10.1039/d0sc00074d   
2020 He Y, Wu Y, Mei B, Fang X, Cai G, Cai N, Wu Q, Huang Z, Ge C, Liang H, Zhang B, Chen X, Chu L. A small nucleolar RNA, SNORD126, promotes adipogenesis in cells and rats by activating the PI3K-AKT pathway. Journal of Cellular Physiology. PMID 32960468 DOI: 10.1002/jcp.30066   
2020 Brod F, Fässler R. A FAK conundrum is solved: activation and organization of focal adhesion kinase at the plasma membrane. The Embo Journal. e106234. PMID 32865270 DOI: 10.15252/embj.2020106234   
2020 Bogdanow B, Schmidt M, Weisbach H, Gruska I, Vetter B, Imami K, Ostermann E, Brune W, Selbach M, Hagemeier C, Wiebusch L. Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis. Nature Communications. 11: 4845. PMID 32973148 DOI: 10.1038/s41467-020-18542-1   
2020 Fang CY, Lai TC, Hsiao M, Chang YC. The Diverse Roles of TAO Kinases in Health and Diseases. International Journal of Molecular Sciences. 21. PMID 33050415 DOI: 10.3390/ijms21207463   
2020 Lacey BM, Xu Z, Chai X, Laskey J, Fradera X, Mittal P, Mishra S, Piesvaux J, Saradjian P, Shaffer L, Vassileva G, Gerdt C, Wang Y, Ferguson H, Smith DM, et al. Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors. Slas Discovery : Advancing Life Sciences R & D. 2472555220952071. PMID 32844715 DOI: 10.1177/2472555220952071   
2020 Shaaya M, Fauser J, Zhurikhina A, Conage-Pough JE, Huyot V, Brennan M, Flower CT, Matsche J, Khan S, Natarajan V, Rehman J, Kota P, White FM, Tsygankov D, Karginov AV. Light-Regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife. 9. PMID 32965214 DOI: 10.7554/eLife.60647   
2020 Frank SJ. Classical and novel GH receptor signaling pathways. Molecular and Cellular Endocrinology. 110999. PMID 32835785 DOI: 10.1016/j.mce.2020.110999   
2020 Song P, Song B, Liu J, Wang X, Nan X, Wang J. Blockage of PAK1 alleviates the proliferation and invasion of NSCLC cells via inhibiting ERK and AKT signaling activity. Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. PMID 32974862 DOI: 10.1007/s12094-020-02486-5   
2020 Vural A, Lanier SM. Intersection of two key signal integrators in the cell: activator of G protein Signaling 3 and Dishevelled-2. Journal of Cell Science. PMID 32737219 DOI: 10.1242/jcs.247908   
2020 Pierotti CL, Tanzer MC, Jacobsen AV, Hildebrand JM, Garnier JM, Sharma P, Lucet IS, Cowan AD, Kersten WJ, Luo MX, Liang LY, Fitzgibbon C, Garnish SE, Hempel A, Nachbur U, et al. Potent inhibition of Necroptosis by simultaneously targeting multiple effectors of the pathway. Acs Chemical Biology. PMID 32902249 DOI: 10.1021/acschembio.0c00482   
2020 Zhang X, Liu Z, Wu S, Sun M, Wei J, Qin Q. Fish RIP1 Mediates Innate Antiviral Immune Responses Induced by SGIV and RGNNV Infection. Frontiers in Immunology. 11: 1718. PMID 32849607 DOI: 10.3389/fimmu.2020.01718   
2020 Agrawal R, Jiří F, Thakur JK. Kinase module of Mediator Complex: Important Signalling Processor for Development and Survival of Plants. Journal of Experimental Botany. PMID 32945869 DOI: 10.1093/jxb/eraa439   
2020 Al-Yozbaki M, Acha-Sagredo A, George A, Liloglou T, Wilson CM. Balancing neurotrophin pathway and sortilin function: Its role in human disease. Biochimica Et Biophysica Acta. Reviews On Cancer. 188429. PMID 32956766 DOI: 10.1016/j.bbcan.2020.188429   
2020 Zhang M, Jang H, Nussinov R. Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases. Journal of Molecular Biology. PMID 32918948 DOI: 10.1016/j.jmb.2020.09.002   
2020 Sammon D, Hohenester E, Leitinger B. Two-step release of kinase autoinhibition in discoidin domain receptor 1. Proceedings of the National Academy of Sciences of the United States of America. 117: 22051-22060. PMID 32839343 DOI: 10.1073/pnas.2007271117   
2020 Han R, Wang J, Chen H, Luo X, Li A, Dan X, Li Y. Grouper (Epinephelus coioides) IRAK-4 regulates activation of NF-κB and expression of inflammatory cytokines in grouper spleen cells. Fish & Shellfish Immunology. PMID 32919054 DOI: 10.1016/j.fsi.2020.09.011   
2020 Colella B, Colardo M, Iannone G, Contadini C, Saiz-Ladera C, Fuoco C, Barilà D, Velasco G, Segatto M, Di Bartolomeo S. mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells. Cancers. 12. PMID 32823532 DOI: 10.3390/cancers12082266   
2020 Cochrane VA, Wu Y, Yang Z, ElSheikh A, Dunford J, Kievit P, Fortin DA, Shyng SL. Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors. The Journal of Biological Chemistry. PMID 33037073 DOI: 10.1074/jbc.RA120.015489   
2020 Chen L, Chen Y, Zhang C, Jiao B, Liang S, Tan Q, Chai H, Yu W, Qian Y, Yang H, Yao W, Yu J, Luo Y, Plewe M, Wang J, et al. Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders. Journal of Medicinal Chemistry. PMID 33058680 DOI: 10.1021/acs.jmedchem.0c01342   
2020 Byun JA, Akimoto M, VanSchouwen B, Lazarou TS, Taylor SS, Melacini G. Allosteric pluripotency as revealed by protein kinase A. Science Advances. 6. PMID 32937500 DOI: 10.1126/sciadv.abb1250